Plural Oxygens Patents (Class 514/718)
  • Patent number: 10287228
    Abstract: The present disclosure relates to compounds and compositions for the treatment of malarian diseases. The compounds comprise a class of halogenated alkyl-aromatic secondary metabolites, including hierridic C, or pharmaceutically acceptable salts, esters, solvates or prodrugs thereof. The compounds comprise a halogen; C1-C6 alkyl, H, COCH3, COH, CO-alkyl, or CO-aryl; and a C3-C30 alkyl. In at least one embodiment, the compound is 3-chloro-4,6-dimethoxy-2-pentadecylphenol. The present disclosure also relates to methods of obtain the compounds from a solution comprising a cyanobacterium.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: May 14, 2019
    Assignees: UNIVERSIDADE DO PORTO, INSTITUTO DE HIGIENE E MEDICINA TROPICAL, INSTITUTO POLITÉCNICO DO PORTO, CIIMAR—Terminal de Cruzeiros do Porto de Leixões
    Inventors: Pedro Nuno Da Costa Leão, Maria Do Rosário Martins, Margarida Costa, Vítor Vasconcelos, Valentina Domingues, Fátima Nogueira
  • Patent number: 9630896
    Abstract: The present disclosure provides phenolic compounds useful in the treatment of neurological conditions such as convulsions and tremors, having the structure of Formula (I): wherein R2, R4, & R5, are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating neurological conditions.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: April 25, 2017
    Assignee: TANSNA THERAPEUTICS, INC.
    Inventors: Max Baker, Rajesh Kumar Mishra, John J. Talley, Eduardo J. Martinez
  • Patent number: 9585389
    Abstract: An aqueous microbicidal composition having two components. The first component is a nonionic surfactant with structure: R1O(CH2CH(CH3)O)5(CH2CH2O)9H, where R1 is a C8 alkyl group. The second component is phenoxyethanol. The weight ratio of the nonionic surfactant to phenoxyethanol is from 1:1 to 1:18.2766.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: March 7, 2017
    Assignees: DOW GLOBAL TECHNOLOGIES LLC, ROHM AND HAAS COMPANY
    Inventors: Usha Gandhi, Christine McInnis, Kiran Pareek, Paul O. Schook, Nigel G. Watson, Terry Michael Williams, Bei Yin
  • Patent number: 9206230
    Abstract: The present invention provides a protecting reagent that can be removed in a high yield even under acidic conditions and can afford a resulting product at a high purity in an organic synthesis reaction such as peptide synthesis and the like. The inventive protecting reagent is particular benzylic compound having only one hydroxyl group substituted by an organic group having an aliphatic hydrocarbon group having a carbon number of not less than 14.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: December 8, 2015
    Assignee: AJINOMOTO CO., INC.
    Inventor: Daisuke Takahashi
  • Publication number: 20150148430
    Abstract: The present disclosure provides phenolic compounds useful in the treatment of neurological conditions such as convulsions and tremors, having the structure of Formula (I): wherein R2, R4, & R5, are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating neurological conditions.
    Type: Application
    Filed: November 24, 2014
    Publication date: May 28, 2015
    Inventors: Max Baker, Rajesh Kumar Mishra, John J. Talley, Eduardo J. Martinez
  • Publication number: 20150110871
    Abstract: The present invention relates to a gastric retentive tablet composition comprising: (1) coated particles essentially consisting of a drug and an amino methacrylate copolymer, (2) a methacrylic acid copolymer and (3) an excipient, wherein items 1, 2, and 3 are blended together, and then compressed into a gastric retentive tablet. Thus, the coated particles (item 1), a methacrylic acid copolymer and the excipient are evenly distributed in the tablet. The excipient is selected from a group consisting of a retarding agent, a binder, a filler, a chelating agent, a diluent, a disintegrant, a lubricant, a colorant, a solubilizing agent, or a mixture thereof. The coated particles (item 1) do not contain methacrylic acid polymer.
    Type: Application
    Filed: January 3, 2015
    Publication date: April 23, 2015
    Inventor: David Wong
  • Patent number: 9012513
    Abstract: Problem To provide an antioxidant, an antioxidant composition, and a method for producing the antioxidant and the antioxidant composition, which feature a high content rate and degree of extraction of substances. These substances are taurine, glycogen, protein, so-called blood platelet anticoagulant with zinc, fat-soluble vitamin with a high activation such as vitamin D, and other useful substances. The antioxidant and the antioxidant composition also feature a so-called antioxidative property, which has recently attracted attention. Solution The present invention, for example, includes 3,5-dihydroxy-4-methoxybenzyl alcohol.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: April 21, 2015
    Assignees: Watanabe Oyster Laboratory Co., Ltd., National University Corporation Hokkaido University
    Inventors: Mitsugu Watanabe, Hitoshi Chiba, Hirotoshi Fuda, Shigeki Jin
  • Patent number: 9006293
    Abstract: The invention provides compositions comprising xanthohumol/cyclodextrin complexes that are water soluble and that have increased stability relative to xanthohumol alone.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: April 14, 2015
    Assignee: Flaxan GmbH & Co. KG
    Inventors: Naoto Yamaguchi, Mitsunori Ono
  • Patent number: 8969407
    Abstract: At least one compound selected from among coumarin and/or derivative thereof, butylated hydroxyanisole, ethoxyquine and mixtures thereof, and admixtures thereof with other active agents selected from among active agents for combating desquamative conditions of the scalp, plant extracts having propigmenting activity and active agents that slow hair loss and/or promote hair regrowth, are useful for preventing and/or limiting and/or stopping the development of canities.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: March 3, 2015
    Assignee: L'Oreal
    Inventor: Stephane Commo
  • Patent number: 8962693
    Abstract: This invention concerns a method for treatment or prevention of lower urinary tract symptoms with or without pelvic pain in an individual, said method comprising administering to the individual an effective amount of a selective estrogen receptor modulator, or an isomer, isomer mixture or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: February 24, 2015
    Assignee: Hormos Medical Ltd.
    Inventors: Risto Santti, Tomi Streng
  • Patent number: 8933129
    Abstract: The present teachings provide compounds of Formulae I and II: and pharmaceutically acceptable salts, hydrates, complexes, esters, and prodrugs thereof, wherein R1, R1?, R2, R2?, R3, R3?, and X are as defined herein. The present teachings also provide methods of making the compounds of formulae I and II, and methods of treating RyR-associated conditions, disorders, and diseases that include administering a therapeutically effective amount of a compound of formula I or II to a subject in need thereof. In addition, the present teachings relate to methods of reducing the open probability of a ryanodine receptor, and methods of reducing Ca2+ release across a ryanodine receptor (e.g., into the cytoplasm of a cell), by contacting a compound of formula I or II with a ryanodine receptor.
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: January 13, 2015
    Assignee: State of Oregon by and through the State Board of Higher Education on behalf of Portland State University
    Inventors: Jonathan Abramson, Robert Strongin
  • Publication number: 20150005390
    Abstract: The present invention relates to a method for treating inflammatory disorder, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of 2-methoxy-4-methylphenol or a pharmaceutically acceptable salt or a physiologically functional derivative thereof, wherein the compound is in a therapeutically effective amount to inhibit NO or IL-6 expression, caspase-1 activation or IL-1? secretion, and NLRP3 and IL-1? precursor expression in inflammatory cells of the subject.
    Type: Application
    Filed: June 28, 2013
    Publication date: January 1, 2015
    Inventors: Shuk-Man KA, Kuo-Feng HUA, Ann CHEN
  • Publication number: 20140369953
    Abstract: Disclosed are compositions comprising a) an antimicrobial agent, which is selected from the group consisting of biocides containing halogen atoms and/or containing phenolic moieties, formic acid, chlorine dioxide, chlorine dioxide generating compounds, dialdehydes; components containing an antimicrobial metal such as antimicrobial silver, and b) a polyamine, especially a polyethylenimine. The polyamine is effective as a booster for the antimicrobial agent.
    Type: Application
    Filed: February 19, 2013
    Publication date: December 18, 2014
    Applicant: BASF SE
    Inventors: Janina Purschwitz, Stephan Hüffer, Alejandra Garcia Marcos, Menno Hazenkamp
  • Publication number: 20140364418
    Abstract: A topical composition providing reduced irritation that contains aromatic alcohols such as phenoxyethanol and a TRPV-1 antagonist is described. The composition is substantially free of parabens. The composition may be used for example for cleansing the skin.
    Type: Application
    Filed: May 15, 2014
    Publication date: December 11, 2014
    Applicant: Johnson & Johnson Consumer Companies, Inc.
    Inventors: Slawomir Cebulski, Michelle Garay, Karien J. Rodriguez, Michael D. Southall, Simarna Kaur
  • Patent number: 8906960
    Abstract: A transdermal fluid is provided wherein the main ingredient is tocotrienol and curcumin is added to enhance the anti-cancer effects of tocotrienols. The composition is useful for the treatment or prevention of a cancer, a tumor or an inflammatory disorder, particularly breast cancer.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: December 9, 2014
    Assignee: Malaysian Palm Oil Board
    Inventors: Kalanithi Nesaretnam, Kanga Rani Selvaduray
  • Publication number: 20140348774
    Abstract: The present inventions relate to a number of fields including wound healing, a waterless antibacterial disinfectant, a surgical scrub, insect repellant, and methods of treating traumatic injuries, particularly those on the battlefield where there is a need to stabilize the patient and prevent infection.
    Type: Application
    Filed: June 9, 2014
    Publication date: November 27, 2014
    Applicant: Aurora Pharmaceutical, LLC
    Inventors: Michael Strobel, Gene Komer
  • Publication number: 20140341988
    Abstract: Pharmaceutical dosage forms, particularly dosage forms in granular form having good palatability and capable of rapidly and completely dispersed in the mouth when orally administered.
    Type: Application
    Filed: May 15, 2014
    Publication date: November 20, 2014
    Applicant: APR APPLIED PHARMA RESEARCH SA
    Inventors: Alberto REINER, Giorgio REINER
  • Publication number: 20140308338
    Abstract: A dressing for applying to the skin is characterized in that the adhesive mass is applied discontinuously in a strip or wave and contains an active substance.
    Type: Application
    Filed: August 29, 2012
    Publication date: October 16, 2014
    Applicant: BEIERSDORF AG
    Inventors: Jens Nierle, Karl-Heinz Woeller, Maxi Zier, Gerd Mueller
  • Publication number: 20140302169
    Abstract: A method wherein subjects having or at risk for having hyperopia, presbyopia or astigmatism are administered a composition having an effective amount of ocular antioxidants, including specifically macular pigments, to prevent, treat, or delay the onset of age-related macular degeneration (AMD).
    Type: Application
    Filed: June 18, 2014
    Publication date: October 9, 2014
    Inventor: Richard Roberts
  • Publication number: 20140296343
    Abstract: Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule.
    Type: Application
    Filed: March 31, 2014
    Publication date: October 2, 2014
    Inventors: Frank M. LONGO, Stephen M. MASSA, Sandeep GUPTA
  • Publication number: 20140275151
    Abstract: A liquid composition is provided. The composition includes at least one active pharmaceutical ingredient dissolved in a liquid carrier system. The liquid carrier includes polyethylene glycol and a co-solvent selected from the group consisting of: propylene glycol, glycerin, and a sugar alcohol. The composition is essentially dye tree, present as a single-phase at room temperature, and optionally contains water.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 18, 2014
    Inventors: Mahesh Sudhakar BHARATI, Houphouet Hyacinthe YARABE
  • Patent number: 8828414
    Abstract: Provided are biocidal compositions comprising 2,6-dimethyl-m-dioxane-4-ol acetate and a non-formaldehyde releasing biocidal compound selected from the group consisting of: a brominated nitroalkanol, a 2-halo-2-(halomethyl)glutaronitrile, and 2-phenoxyethanol. The compositions are useful for controlling microorganisms in aqueous or water containing systems.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: September 9, 2014
    Assignee: Dow Global Technologies LLC
    Inventors: Kathy J. Ji, Donald J. Love, Jon B. Raymond
  • Patent number: 8808743
    Abstract: Benzonatate resinates of weak acid ion exchange resins having the same distribution of butyl 4-aminobenzoate homologs as exist in the benzonatate listed in the F.D.A. Orange Book as Application No. N011210. These resinates, in simulated gastrointestinal dissolution, release essentially the same distribution of butyl-4 aminobenzoate homologs as exist in the benzonatate listed in the F.D.A. Orange Book as Application No. N011210.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: August 19, 2014
    Inventors: William Wayne Howard, Russell Francis Somma
  • Patent number: 8796326
    Abstract: A fire ant killer chemical composition (the “FAK Composition”) for effective killing of fire ants where the FAK Composition utilizes a minimal amount of active ingredients thereby significantly reducing safety concerns with respect to the use of said active ingredients, the FAK composition having a dish detergent composition and an insecticide composition.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: August 5, 2014
    Inventor: Harold V. Hutchins
  • Publication number: 20140213660
    Abstract: The present invention relates to a cosmetic method for treating and/or preventing greasy skin or greasiness-prone skin and/or the associated cutaneous aesthetic defects, comprising the topical application to the skin of a composition comprising, in a cosmetically acceptable medium, at least one compound of formula (I): in which: R represents a hydrogen atom or a saturated or unsaturated and linear or branched C1-C6 hydrocarbon radical; R? represents a saturated or unsaturated and linear or branched C1-C18 hydrocarbon radical, optionally substituted by a hydroxyl group; C—X represents C?O or CH—OH.
    Type: Application
    Filed: March 30, 2012
    Publication date: July 31, 2014
    Applicant: L'OREAL
    Inventor: Maria Dalko
  • Patent number: 8729070
    Abstract: The present invention is directed to CNS pharmaceutical compositions and methods of use. The pharmaceutical compositions comprise a CNS active agent and preferably at least two vagal neuromodulators, one of which is a mechanoreceptor stimulator. The vagal neuromodulators are preferably in an amount sufficient to reduce a somnolence side-effect of the CNS active agent without changing its therapeutic efficacy/activity. The invention further encompasses a method of reducing CNS active agent side-effects. The method typically comprises oral administration of at least one CNS active agent to a patient at the conventionally accepted dose; and administration of at least two vagal neuromodulators to the patient so that at least one neuromodulator is administered or released from dosage form after the CNS active agent is administered and/or released.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: May 20, 2014
    Assignee: Targia Pharmaceuticals
    Inventor: Sabina Glozman
  • Patent number: 8673819
    Abstract: The present invention teaches a surfactant blend composition of at least one nonionic alkoxylate and at least one sugar-based surfactant, and its use as an adjuvant for pesticides. The pesticidal composition employing the surfactant blend composition of the invention realizes an efficacy that is unexpectedly superior to similar pesticidal compositions which employ only the individual surfactant components. The composition of the present invention is useful as a tank side additive, or as a component in herbicidal formulations. In addition the compositions of the present invention are useful as adjuvants for other pesticides, such as, fungicides, insecticides, plant growth regulators, acaracides and the like.
    Type: Grant
    Filed: July 3, 2009
    Date of Patent: March 18, 2014
    Assignee: Akzo Nobel N.V.
    Inventor: Jinxia Susan Sun
  • Publication number: 20140050678
    Abstract: The present invention relates to the use, as an antidandruff agent, of a compound of formula: in which: R1 represents a hydrogen atom or a hydrocarbon-based radical; R? represents a C1-C18 hydrocarbon-based radical, optionally substituted with a hydroxyl group; C—X represents C?O or CH—OH.
    Type: Application
    Filed: March 30, 2012
    Publication date: February 20, 2014
    Applicant: L'OREAL
    Inventor: Maria Dalko
  • Publication number: 20140045695
    Abstract: The invention relates to continuous fiber layers comprising an active substance on the basis of bio-polymers, comprising a fibrous, bio-polymer active substance carrier, and at least one active substance associated with the carrier and releasable from the continuous fiber layer; to formulations comprising an active substance, the formulations comprising such continuous fiber layers; to the use of continuous fiber layers comprising an active substance for the production of formulations comprising an active substance; and to a method for the production of continuous fiber layers comprising an active substance. The invention further relates to corresponding continuous fiber layers comprising an active substance and to the use thereof for the production of wound treatment and hygiene products, and to the respectively produced wound treatment and hygiene products.
    Type: Application
    Filed: October 24, 2013
    Publication date: February 13, 2014
    Applicant: BASF SE
    Inventors: BURGHARD LIEBMANN, EVGUENI KLIMOV
  • Publication number: 20140024689
    Abstract: Method for reducing the formaldehyde emission of a composition containing a formal by adding urea, urea derivatives, amino acids, guanidine or guanidine derivatives.
    Type: Application
    Filed: September 25, 2013
    Publication date: January 23, 2014
    Applicant: AIR LIQUIDE SANTE (INTERNATIONAL)
    Inventors: Wolfgang BEILFUSS, Ralf GRADTKE, Iigo KRULL, Klaus WEBER
  • Publication number: 20140017301
    Abstract: The present invention provides drug-free adaptable aggregate compositions, typically having a form of bilayer vesicles suspended in a polar, optionally thickened, fluid comprising different pharmaceutically acceptable excipients for use in or on a mammal for any medical indication, specifically for non-invasive treatment of local inflammation and the associated pain, in particular for use on the skin and underlying tissues, including muscles and/or superficial joints. Accompanying guidelines for selecting components to thereby optimizing the formulations are also provided.
    Type: Application
    Filed: March 21, 2012
    Publication date: January 16, 2014
    Inventor: Gregor Cevc
  • Publication number: 20130303629
    Abstract: Problem To provide an antioxidant, an antioxidant composition, and a method for producing the antioxidant and the antioxidant composition, which feature a high content rate and degree of extraction of substances. These substances are taurine, glycogen, protein, so-called blood platelet anticoagulant with zinc, fat-soluble vitamin with a high activation such as vitamin D, and other useful substances. The antioxidant and the antioxidant composition also feature a so-called antioxidative property, which has recently attracted attention. Solution The present invention, for example, includes 3,5-dihydroxy-4-methoxybenzyl alcohol.
    Type: Application
    Filed: January 26, 2012
    Publication date: November 14, 2013
    Inventors: Mitsugu Watanabe, Hitoshi Chiba, Hirotoshi Fuda, Shigeki Jin
  • Publication number: 20130274231
    Abstract: Compositions containing an effective dermatological disease-treating or dermatological condition-treating active agent and a pharmaceutically-acceptable carrier or vehicle are disclosed.
    Type: Application
    Filed: June 17, 2013
    Publication date: October 17, 2013
    Inventor: Bryan B. Fuller
  • Publication number: 20130217574
    Abstract: The present invention relates to compositions that include a combination of one or more pesticides and one or more adjuvants.
    Type: Application
    Filed: March 15, 2013
    Publication date: August 22, 2013
    Applicant: BAYER CROPSCIENCE LP
    Inventor: BAYER CROPSCIENCE LP
  • Publication number: 20130217773
    Abstract: This invention is designed for the convenient and reliable delivery of predetermined doses of topical therapeutic medications applied to the skin. The importance of this method of application is that it allows reducing the amount of a therapeutic agent used in one session or reducing amount of sessions per day by eliminating the application of medications to a treating surface by hand. The emphasis is on making therapeutic agents available for self-administration, especially for partially disabled people with conditions such as arthritis and/or visual impairments who would not be able to use these medications without assistance.
    Type: Application
    Filed: February 22, 2012
    Publication date: August 22, 2013
    Inventor: Mikhail Levitin
  • Patent number: 8481600
    Abstract: Disclosed herein are ways to solubilize aspirin for parenteral administration containing aspirin and a diluent NNDMA (N,N-Dimethylacetamide) useful in the treatment of acute coronary syndromes as well as other disease states. The solution so constituted is stable at room temperature for prolonged periods without decomposition and avoids significant hydrolysis of the aspirin and thus the loss of the anti-platelet action when stored.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: July 9, 2013
    Assignee: Academic Pharmaceuticals, Inc.
    Inventors: John Charin Somberg, Vasant V Ranade
  • Publication number: 20130156708
    Abstract: The invention relates to the use of (i) a compound of formula (I) or a (pharmaceutically) acceptable salt thereof or (ii) a mixture comprising one or more or consisting of two or more compounds of formula (I) and/or said salts wherein R1 denotes a radical in ortho-, meta, or para-position to the phenolic OH group, the radical being selected from the group consisting of E/Z-3-methylbut-1-en-1-yl, 3-methylbut-2-en-1-yl and 3-methylbut-3-en-1-yl and R2 denotes a radical in ortho-, meta, or para-position to the phenolic OH group, the radical being selected from the group consisting of H and alkyl groups with 1 to 3 C atoms as antimicrobial agent for inactivation of microorganisms, in particular for rapid inactivation of microorganisms, with the proviso that the use is not within a method for treatment of the human or animal body by surgery or therapy or within a diagnostic method practised on the human or animal body.
    Type: Application
    Filed: October 25, 2012
    Publication date: June 20, 2013
    Applicant: Symrise AG
    Inventor: Symrise AG
  • Publication number: 20130149383
    Abstract: Sustained release particle formulations formed from a hydrophobic wax matrix and guaifenesin.
    Type: Application
    Filed: December 12, 2012
    Publication date: June 13, 2013
    Inventors: Cory Berkland, Milind Singh
  • Patent number: 8455457
    Abstract: Provided herein is a pharmaceutical composition or a kit comprising a combination of a non-selective beta-adrenergic receptor blocker and an adenosine A1 receptor agonist. Also provided herein is a method of reducing intraocular pressure (IOP) in a subject using such a combination or kit. In a particular embodiment, provided herein is a combination of timolol marketed under the brand Timoptic™ and Compound A.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: June 4, 2013
    Assignee: Inotek Pharmaceuticals Corporation
    Inventors: Norman N. Kim, William K. McVicar, Thomas G. McCauley
  • Publication number: 20130136709
    Abstract: The invention relates to synergistically effective ternary antimicrobial mixtures.
    Type: Application
    Filed: November 5, 2012
    Publication date: May 30, 2013
    Applicant: SYMRISE AG
    Inventor: Symrise AG
  • Publication number: 20130131185
    Abstract: The invention provides in part dialkoxybenzene compounds for controlling infestation by a Trichoplusia ni, and methods thereof. The compounds include a compound of Formula I: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; R2 may be at positions 2, 3 or 4 and may be H, methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; and R3 may be optionally present at positions 2, 3 and 4, and is allyl; except that when R2 is at position 2, R3 if present is at position 3, and when R2 is at position 3, R3 if present is at to positions 2 or 4, and when R2 is at position 4, R3 if present is at position 2, and when R2 is at position 4 and R3, if present, has reacted with an OH group at position 1 in a Markovnikov sense, then R3 becomes R4, a dihydrofuran.
    Type: Application
    Filed: January 4, 2013
    Publication date: May 23, 2013
    Applicants: THE UNIVERSITY OF BRITISH COLUMBIA, SIMON FRASER UNIVERSITY
    Inventors: SIMON FRASER UNIVERSITY, THE UNIVERSITY OF BRITISH COLUMBIA
  • Patent number: 8436013
    Abstract: The invention features compositions and methods that are useful for treating or preventing AAT deficiency and associated conditions. In addition, the invention provides methods for identifying compounds useful for treatment of AAT deficiency and associated conditions.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: May 7, 2013
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Chen Liu, David A. Ostrov
  • Patent number: 8398340
    Abstract: A method of extracting the contents from the inside of a reactor kept at high temperature and high pressure includes the steps of introducing the contents of the reactor into a pipe having an internal space which communicates with the reactor, closing the pipe to enclose the contents in the internal space, removing unnecessary gas from the internal space, and supplying an inert gas to the internal space, thereby replacing the contents enclosed in the internal space with the inert gas. The contents are discharged from the internal space by replacing the contents enclosed in the internal space with the inert gas.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: March 19, 2013
    Assignees: Nippon Steel Engineering Co., Ltd., Japan Oil, Gas and Metals National Corporation, Inpex Corporation, JX Nippon Oil & Energy Corporation, Japan Petroleum Exploration Co., Ltd., Cosmo Oil Co., Ltd.
    Inventors: Yasuhiro Onishi, Yuzuru Kato, Atsushi Murata, Eiichi Yamada
  • Patent number: 8357398
    Abstract: Oral dosage forms of benzonatate useful for anti-tussive and anti-tussive/combination applications.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: January 22, 2013
    Assignee: Alitair Pharmaceuticals Inc.
    Inventors: William Wayne Howard, Russell Francis Somma, Doreen Marie Frank
  • Patent number: 8344021
    Abstract: At least one compound selected from among coumarin and/or derivative thereof, butylated hydroxyanisole, ethoxyquine and mixtures thereof, and admixtures thereof with other active agents selected from among active agents for combating desquamative conditions of the scalp, plant extracts having propigmenting activity and active agents that slow hair loss and/or promote hair regrowth, are useful for preventing and/or limiting and/or stopping the development of canities.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: January 1, 2013
    Assignee: L'Oreal
    Inventor: Stephane Commo
  • Publication number: 20120321727
    Abstract: Disclosed are edible formulations, for example, edible films and gummi confectioneries, that mask the taste of semen. The films and confectioneries include a composition that upon activation in the oral cavity provides a lasting taste masking effect that endures for up to 20 minutes. The composition includes a film former or gelling agent, an effective amount of a protein masker, and an effective amount of a bitter masker. The composition may also include a flavoring agent, sweetening agents, and sensates.
    Type: Application
    Filed: April 25, 2012
    Publication date: December 20, 2012
    Applicant: ACME SPECIALTY PRODUCTS, LLC
    Inventors: Robert J. Windschauer, Teresa T. Virgallito
  • Publication number: 20120237458
    Abstract: Hydrogel particles include: (A) a water-insoluble complex containing catechins; (B) a compound which forms chelate together with divalent or trivalent metal ions; (C) a divalent or trivalent metal salt; (D) a gel-forming agent; and (E) water.
    Type: Application
    Filed: November 30, 2010
    Publication date: September 20, 2012
    Inventors: Yasuhiro Shidahara, Michiya Takagi, Kimikazu Fukuda, Susumu Nakatsu, Ikuhisa Ichimura, Tadayuki Tokunaga
  • Publication number: 20120219636
    Abstract: A formulation and method for removing viruses from fresh produce, including at least one surfactant, and a solvent. Preferably, the formulation also includes at least one sanitizer.
    Type: Application
    Filed: February 28, 2012
    Publication date: August 30, 2012
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Jianrong Li, Ashley Predmore
  • Publication number: 20120208767
    Abstract: A method includes obtaining a biological sample from a subject that does not display a symptom of Painful Bladder Syndrome (PBS). The method also includes analyzing the biological sample for a mutated form of NAD(P)H dehydrogenase [quinone], also known as Quinone Oxidoreductase 1, abbreviated NQO1, or a mutation of a NQO1 gene. The method also includes determining a risk of PBS for the subject based on analyzing the biological sample. In some methods, the mutation determined to present an increased risk is a cytosine to thymine nucleotide substitution at a position that leads to a proline to serine amino acid substitution at amino acid position 187 to produce a protein NQO1P187S. Another method includes selecting a subject that has above normal risk of Painful Bladder Syndrome (PBS) or is expressing a symptom of PBS, and treating the subject with a therapeutically effective amount of an antioxidant.
    Type: Application
    Filed: February 14, 2012
    Publication date: August 16, 2012
    Applicant: University of Maryland, Baltimore
    Inventor: Anil K. Jaiswal
  • Publication number: 20120201887
    Abstract: A pharmaceutical composition in the form of a tablet including a first portion and a second portion, wherein said first portion includes guaifenesin having an immediate release profile and a second drug having a sustained release profile, and wherein the second portion includes guaifenesin having a sustained release profile. The second drug can be in the form of a drug-resin complex. The second drug can be either an anti-tussive or a decongestant. The drug-resin complex includes a drug complexed to an ion exchange resin. The ion exchange resin can be a polystyrene sulfonate resin, polacrilex resin, polacrilin potassium, cholestyramine resin, or a colestyramine resin. The drug-resin complex can be provided with a coating, the coating thickness being selected to obtain the desired release profile. The drug-resin complex can be provided with a coating level of from 5% to 50%. The coating level can be from 10% to 35%.
    Type: Application
    Filed: February 4, 2011
    Publication date: August 9, 2012
    Applicant: Reckitt Benckiser LLC
    Inventors: Nils Ahlgren, Mark Nuttall, Jeannie Wong, Venkatesh Balasubramanian, Craig Belongie, Ashfaq Khan, Neil Campbell Muir