Abstract: Injectable contrast agents of great clinical importance for lymphography, characterized by non-water soluble particle sizes between about 5 or 10 nm and about 500 or 900 nm, which have selective distribution to lymph nodes upon percutaneous administration and can be imaged with millimeter resolution. Also disclosed are methods for performing percutaneous lymphography using these contrast agents.
Abstract: The present invention relates to compositions and their methods of manufacture and use which are effective for delivering a homogeneous distribution of a boron containing active ingredient to a tree or tree derived substrate for the purpose of preventing or eradicating an infestation and/or for imparting flame retardency thereto.
Type:
Grant
Filed:
May 24, 1990
Date of Patent:
April 14, 1992
Assignee:
Nisus Corp.
Inventors:
Vincent R. Palmere, Allan H. Dietrich, Stanley D. Galyon
Abstract: A barrier cream consisting essentially of at least one active ingredient chosen from the alkali metal salts of phenols, dispersed in a substantially anhydrous state in a base medium comprising a polyethylene glycol which has been at least partially etherified to reduce the free hydroxyl group content thereof. These creams are simple to prepare, effective for a reasonable period of time and do not produce adverse skin reaction, and are simple both to apply and to remove. They afford protection against chemical warfare agents of both the V and G types, and against mustard gas (H or HD).
Type:
Grant
Filed:
November 20, 1984
Date of Patent:
December 31, 1991
Assignee:
Her Majesty Queen as represented by Minister of National Defence Canada
Inventors:
Robert A. B. Bannard, Alfred A. Casselman, John G. Purdon, John W. Bovenkamp
Abstract: Biocompatible fluorcarbon emulsions having fluorocarbon in concentrations of from 75% weight per volume to 125% weight per volume have small, biocompatible particle size stability through heat sterilization with one emulsifying agent, including phospholipids, in concentrations of from 3% to 7% weight per volume. The single emulsifying agent can be hydrogenated lecithins and synthesized lecithins. Fluorocarbon emulsions having fluorocarbon in concentrations of from 40% weight per volume to 125% weight per volume have stability of partial pressure of oxygen and of partial pressure of carbon dioxide through heat sterilization and storage for extended periods of time after having been oxygenated with dissolved oxygen.
Abstract: A protective system against chemical warfare agents consisting essentially of at least one alkali metal salt of phenol, acetone oxime, acetophenone oxime and 2,3-butanedione monoxime, a macrocycle chosen from 18-crown-6 or cryptand [2,2,2] and a solvent chosen from dioxolane, tetraglyme, dimethoxyethane, a polyethylene glycol or a polyethylene glycol mono- or diether the system also containing just enough water to dissolve the active ingredient. These systems afford protection against mustard gas (H or HD) and against chemical warfare agents of the V and G types.
Type:
Grant
Filed:
November 20, 1984
Date of Patent:
December 24, 1991
Assignee:
Her Majesty the Queen in right of Canada, as represented by the Minister of National Defence of Her Majesty's Canadian Government
Inventors:
Robert A. B. Bannard, Alfred A. Casselman, John G. Purdon, John W. Bovenkamp
Abstract: Topically applied compositions for the accelerated rejuvenation of skin and an associated method of skin care treatment are disclosed utilizing vitamin A propionate of the general formula ##STR1## in an aqueous based carrier at a concentration ranging from 0.1% to 4.0%. The carrier may include non-ionic surfactants, preservatives and thickeners. The vitamin A propionate composition is topically applied to the skin at a frequency which is determined by skin type as determined by skin oil production rate.
Abstract: This invention relates to the discovery that a very particular kind of nonionic surfactant, namely an alkyloxypolyethyleneoxyethanol can be used as the sole active ingredient to control fungus, mites, worms, termites, nematodes and other insects. It is believed that these alkyloxypolyethyleneoxyethanols can be represented by the formula: ##STR1## wherein n is from 9 to 15 and m is from 3 to 40.
Abstract: A fat and oil composition comprises (1) as the main triglyceride one or more mixed acid triglyceride having one or more saturated C20 to C24 fatty acid residue and one or more unsaturated C16 to C22 fatty acid residue in a molecule thereof and (2) in the entire fatty acid moiety 15 to 70 wt. % of one or more saturated C20 to C24 fatty acids and 20 to 60 wt. % of one or more unsaturated C16 to C22 fatty acids. It is useful as a base of a solid cosmetic preparation.
Abstract: An organ preservation solution, particularly valuable in the preservation of mammalian hearts intended for transplantation, in aqueous solution, at least about 3% by weight of polypropylene glycol having an average molecular weight of at least about 15,000 daltons and being free of material retained by 10 micron filtration, a buffer buffering the pH of the solution perfusate to a value in the range of about 7.1 to about 7.5, and an impermeant composition for retarding the passage of water across cell membranes of an organ treated with the solution.
Abstract: A vaccine for immunizing animals against Feline Leukemia Virus (FeLV) infections contains an FeLV antigen emulsified with a polyoxypropylene-polyoxyethylene block polymer, a glycol ether-based surfactant, an immunopotentiating amount of an immunostimulating glycopeptide, and, optionally, a metabolizable non-toxic oil.
Abstract: A process and compositions for reducing post-surgical adhesion formation/reformation in mammals following surgical injury to the peritoneal or pleural cavity or organs situated therein. Both aqueous and non-aqueous compositions comprising a polyoxyalkylene block copolymer are applied to injured areas of the peritoneal or pleural cavity or organs situated therein subsequent to surgical injury.
Abstract: A stable concentrated aqueous emulsion of perfluorochemical, a phospholipid and a triglyceride of fatty acids has been demonstrated which has enhanced stability, diminished particle size and heightened tolerance by biological systems. The emulsion has utility as an oxygen transport medium, such as artificial blood. The emulsion can optionally include additional emulsifiers of SURFYNOL.RTM.SE surfactant and PLURONIC.RTM. P-105 surfactant. The emulsion is produced using an improved emulsification technique. The invention includes methods of oxygen transport in vascular systems wherein the oxygen carrying capacity of the vascular systems is improved with the emulsions of the present invention. Methods are also described for organ preservation extra-vivo by perfusing, suffusing, flushing and filling organs outside the body with the oxygen carrying emulsions of the present invention.
Type:
Grant
Filed:
March 20, 1987
Date of Patent:
January 23, 1990
Assignee:
Air Products and Chemicals, Inc.
Inventors:
Frank K. Schweighardt, Charles R. Kayhart
Abstract: A bactericidal composition comprises didecyldimethyl didecyldimethylammonium chloride and an alkylene oxide adduct of a polyhydric alcohol being trivalent or more and is effective bactericidally even to feces of a cattle stall.
Abstract: Compositions for cosmetics and dermatology comprising a perfluoropolyether liquid dispersed in an oil/water or water/oil emulsion, or in a solid phase suited to form a gel, suspended in an organic liquid phase.
Type:
Grant
Filed:
March 26, 1986
Date of Patent:
February 7, 1989
Assignee:
Ausimont S.p.A.
Inventors:
Fabio Brunetta, Stefano Bader, Giovanni Pantini
Abstract: Mixture of compounds of general formula: ##STR1## in which R denotes a saturated C.sub.10 -C.sub.12 hydrocarbon radical, or mixture of such radicals, and n has a mean statistical value from 2 to 15, and preferably from 3 to 12.These products are very well tolerated by the skin and the mucosa, and are advantageously used in cosmetic or pharmaceutical compositions.
Abstract: A lamella type, single phase liquid crystal composition is prepared from a hydrophilic nonionic surfactant, a water-soluble substance having a hydroxyl group in a molecule thereof, an oil substance, and water.Oil-base cosmetic compositions including cleansing compositions, massage creams or drugs for external application are incorporated with the liquid crystal.The compositions are readily washed off simply by water, and exhibit good properties of non-stickiness and long storage stability.
Abstract: There is disclosed a method of protecting animals including humans against ionizing radiation by injecting the animals with a polymer having the approximate formula H(OCH.sub.2 CH.sub.2).sub.n OH, where n varies between 4 and 13. Particularly, it is found that polyethylene glycol (molecular weight between 200 and 600), polyethyleneglycolmonoethylether (molecular weight between 200 and 600), and polyvinylpyrrolidone (molecular weight up to 10,000) when injected into standard experimental animals, such as mice, protects them from the lethal effect of ionizing radiation.
Type:
Grant
Filed:
October 24, 1985
Date of Patent:
June 30, 1987
Assignee:
Eastern Virginia Medical Authority/Med. Ctr. Hosp.
Abstract: Compounds of formula (I) ##STR1## where R=C.sub.10-20 alkyl, alkenyl or alkylaryl;G=C.sub.6 H.sub.10 O.sub.5 radical derived from a hexose;u=0 or 1;0.ltoreq.x.ltoreq.10; 0.ltoreq.y.ltoreq.10; 1.ltoreq.x+y.ltoreq.10;a, b, c, d denote zero or a number less than or equal to 5, with the condition that1.ltoreq.a+b+c+d.ltoreq.5 and ##EQU1## These compounds are prepared by addition of (a+b+c+d) moles of an oside or alkylglucoside, or ##EQU2## moles of diholoside, to a compound of formula (II) ##STR2## These compounds are surfactants which can be used in cosmetic and pharmaceutical compositions.
Abstract: This invention relates to novel compounds having pharmaceutical activity and having the general structure ##STR1## wherein the Z, R.sub.1, R.sub.2, R.sub.3, R.sub.4, n and m are defined within.
Type:
Grant
Filed:
November 29, 1984
Date of Patent:
September 30, 1986
Assignee:
USV Pharmaceutical Corp.
Inventors:
Bernard Loev, Howard Jones, Wan-kit Chan
Abstract: A method for enhancing the immunogenicity of an antigen is emulsifying it with a polyoxypropylene-polyoxyethylene block polymer, a glycol ether-based surfactant, a metabolizable non-toxic oil, isoosmotic saline, and an immunopotentiating amount of an immunostimulating glycopeptide.
Abstract: Disclosed is an improved method for controlling mosquitos wherein a body of water containing immature forms of mosquitos has its surface coated with a thin film of a control agent which is a non-ionic, organic material with a density less than that of water. The improvement in such method comprises coating the surface with an approximately monomolecular film of a .beta.-branched alcohol of the following structure: ##STR1## where R.sub.1 and R.sub.2 is C.sub.9 -C.sub.28 ; andR.sub.1 and R.sub.2 is at least C.sub.3, orR.sub.2 is CH.sub.3 and R.sub.1 has at least two branch sites.
Abstract: Topical formulations comprise pseudomonic acid or a salt or ester thereof and a polyethylene glycol or polyethylene glycol analogue or derivative.
Abstract: Antiperspirant/deodorant stick composition which comprises: a powdered antiperspirant agent the particles of which are enrobed in a coating material, contained in a cologne stick base.
Type:
Grant
Filed:
February 22, 1983
Date of Patent:
June 18, 1985
Assignee:
Armour Pharmaceutical Company
Inventors:
Dennis Laba, John J. Margres, Jr., Kristin Burkhardt
Abstract: This application relates to the administering of fatty aldehydes (and acids) to patients suffering from Multiple Sclerosis, for therapeutic purposes.