C Of C-o- Group Is Nuclear C Of A Benzene Ring (e.g., Phenol, Phenolate, Etc.) Patents (Class 514/731)
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Patent number: 8968755Abstract: The invention provides skin-protecting and penetrating, easy-to-administer base and active agent-containing compositions, such as those including hydrocortisone, for treating the skin of mammals for different dermatologic disorders. This is effected by topically administering effective amounts of the compositions thereto in forms that address the skin and mucosa of the mouth and lips, and the rest of the body. Additionally, an optional flavoring addition to these products affords significantly better tasting, and less bitter, compositions, allowing a more pleasant experience and better compliance by patients. The compositions include a unique formulation of FANCOL VB, Natunola Castor 1023, Finsolv TN, bees wax and, optionally, one or a plurality of plant or plant seed oils, fatty alcohols, fats and flavorings, in desirable weight percents thereof, in various forms, and preferably in a form of a solid roll-on stick in a variety of sizes and of a jar or pot.Type: GrantFiled: March 1, 2013Date of Patent: March 3, 2015Inventors: Joel Schlessinger, Daniel Isaac Schlessinger
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Patent number: 8969407Abstract: At least one compound selected from among coumarin and/or derivative thereof, butylated hydroxyanisole, ethoxyquine and mixtures thereof, and admixtures thereof with other active agents selected from among active agents for combating desquamative conditions of the scalp, plant extracts having propigmenting activity and active agents that slow hair loss and/or promote hair regrowth, are useful for preventing and/or limiting and/or stopping the development of canities.Type: GrantFiled: November 30, 2012Date of Patent: March 3, 2015Assignee: L'OrealInventor: Stephane Commo
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Publication number: 20150056298Abstract: According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.Type: ApplicationFiled: October 31, 2014Publication date: February 26, 2015Inventors: Bobak Robert Azamian, Scott Bradley Vafai
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Patent number: 8962696Abstract: The invention provides a method and a composition for enhancing the dissolution and bioavailable properties of propofol (2, 6 diisopropyl phenol) for use as an intravenously administered anesthetic in mammals. The method produces a self-microemulsifyable emulsion base composition that is utilized in the production of a water-based microemulsion preparation. In a preferred two (2) component base composition, the base composition consists of: a surfactant, containing polyethylene glycol; and liquid propofol. The microemulsion is prepared by mixing the base composition with a carrier liquid, which results in the formation of a microemulsion containing concentrations of propofol of up to about 4% by weight of propofol to the volume of the microemulsion. In a four (4) component base composition, the base composition consists of: a surfactant, containing polyethylene glycol; liquid propofol; a water-immiscible solvent; and ethanol.Type: GrantFiled: January 11, 2013Date of Patent: February 24, 2015Assignee: Medos, Inc.Inventors: Steven B. Harris, Nick J. Huang
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Patent number: 8962694Abstract: Compositions suitable for the control of pest amphibian species are described. More particularly, compositions for killing amphibians are described that comprise: (i) a xylenol compound or derivative according to formula (I) wherein R1, R2, R3, R4 and R5 are each independently selected from hydrogen, hydroxyl, halogen, —NH3 and C1-6 alkyl, and —R6—NH2, —R6—ONH2, —R6—NO2, and —R6—PO4, wherein R6 is C1-6 alkyl, and X is selected from hydrogen, halogen and C1-6 alkyl, or a salt thereof, and (ii) ethanol and optionally, (iii) methanol and/or at least one C3-6 alcohol. Methods for killing amphibians include contacting the amphibian with said compositions. Kits are described wherein said xylenol compounds and ethanol and optionally methanol and/or at least one C3-6 alcohol may be administered simultaneously or sequentially.Type: GrantFiled: December 18, 2007Date of Patent: February 24, 2015Assignee: Pestat Pty Ltd.Inventors: David James Dall, Joan Dawes
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Publication number: 20150051297Abstract: The present invention relates to a method for disinfection involving an antimicrobial composition. It particularly relates to an antimicrobial method for personal cleaning, oral care or hard surface cleaning applications. It was found that compositions comprising thymol, acyclic terpene alcohols and a carrier provide synergistic antimicrobial action in a method for disinfection. In a preferred aspect the composition also comprises 1 to 80%-wt of one or more surfactants.Type: ApplicationFiled: December 5, 2012Publication date: February 19, 2015Applicant: ROHM AND HAAS COMPANYInventors: Robert J. Cornmell, Megan A. Diehl, Stephen Golding, John R. Harp, Ian P. Stott, Katherine M. Thompson, Carol L. Truslow
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Publication number: 20150051298Abstract: A method for producing stable nanoemulsions having a desired droplet size and functional properties tailored for use in a specific application (which is referred to as substantially optimizing composition) that includes selecting an aqueous phase; the aqueous phase comprising at least one ingredient from water, surfactant, co-surfactant and co-solvent, the aqueous phase being selected such that a stable nanoemulsions having a desired droplet size and functional properties tailored for use in a specific application is obtained, and selecting an organic phase comprising at least two ingredients from lipophilic component, oil, surfactant, co-surfactant and cosolvent, the organic phase being selected such that a stable nanoemulsions having a desired droplet size and functional properties tailored for use in a specific application is obtained, a nanoemulsion being formed when the organic phase is mixed with the aqueous phase.Type: ApplicationFiled: August 13, 2014Publication date: February 19, 2015Inventors: David J. McClements, Amir H. Saberi, Yuhua Chang, Lynne McLandsborough
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Publication number: 20150050220Abstract: The present invention relates to an antimicrobial composition and a method for disinfection involving the antimicrobial composition. It particularly relates to an antimicrobial composition for personal cleaning, oral care or hard surface cleaning applications. It was found that compositions comprising thymol, p-menthene alcohols and a carrier provide synergistic antimicrobial action. In a preferred aspect the composition also comprises 1 to 80%-wt of one or more surfactants.Type: ApplicationFiled: December 5, 2012Publication date: February 19, 2015Inventors: Robert J. Cornmell, Megan A. Diehl, Stephen Golding, John R. Harp, Ian P. Stott, Katherine M. Thompson, Carol L. Truslow
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Patent number: 8952071Abstract: Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Kearns-Sayre Syndrome (KSS), are disclosed, as well as compounds useful in the methods of the invention, such as 2-(3-hydroxy-3-methyl-butyl)-6-(het)aryl-p-quinone or as 2-(3-hydroxy-3-methylbutyl)-3-(het)aryl-p-quinone derivatives. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.Type: GrantFiled: January 6, 2009Date of Patent: February 10, 2015Assignee: Edison Pharmaceuticals, Inc.Inventors: Andrew W. Hinman, Kieron E. Wesson
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Publication number: 20150038576Abstract: A composition includes a liquid. The liquid aerosolizes for delivery to a user by an airway. The liquid includes an agent that activates a TRPV3 channel. The agent includes a terpenoid compound.Type: ApplicationFiled: August 1, 2014Publication date: February 5, 2015Applicant: SENTIENS, LLCInventors: Inna S. Timokhina, Reid von Borstel, Dennis Tan, John Siverling
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Patent number: 8945596Abstract: The present invention relates to an antimicrobial composition. It particularly relates to an antimicrobial composition for cleansing or personal care. It is an object of the present invention to provide antimicrobial compositions that have relatively fast antimicrobial action. Present inventors have surprisingly found that compositions comprising selected ingredients, namely thymol and terpineol, in selective proportions provide relatively quick antimicrobial action.Type: GrantFiled: October 8, 2009Date of Patent: February 3, 2015Assignee: Conopco, Inc.Inventors: Amit Chakrabortty, Srilaxmi Venkata Medepalli
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Publication number: 20150025152Abstract: A pharmaceutical formulation for treatment of shingles is provided. The formulation includes between 0.2 mg of menthol per 120 mL of the formulation and 1.0 mg of menthol per 120 mL of the formulation, camphor water, lime water, and a local anesthetic. The local anesthetic includes one of between 0.6 mL of phenol per 120 mL of the formulation and 2.0 mL of phenol per 120 mL of the formulation and between 0.25% concentration by weight of lidocaine and 5% concentration by weight of lidocaine.Type: ApplicationFiled: July 16, 2014Publication date: January 22, 2015Inventors: Howard L. Wray, Aman Singh
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Patent number: 8932584Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.Type: GrantFiled: December 27, 2013Date of Patent: January 13, 2015Assignee: Soft Gel Technologies, Inc.Inventor: Michael Fantuzzi
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Patent number: 8932585Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.Type: GrantFiled: January 27, 2014Date of Patent: January 13, 2015Assignee: Soft Gel Technologies, Inc.Inventor: Michael Fantuzzi
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Publication number: 20150004206Abstract: The invention relates to a process for preparing PCL-comprising microparticles, to microparticles obtainable by said process, to gel hence obtained and to several uses of the gel such as for the preparation of a medicament for treating a skin abnormality or disfigurement, and/or for controlling bladder function and/or controlling gastric reflux and/or for treating erectile dysfunction and/or for treating vocal cords. The gel may also be used for cosmetic applications.Type: ApplicationFiled: July 1, 2014Publication date: January 1, 2015Inventors: Henderikus Supèr, Paul Willem Mijnen, Pieter Gerard Zijlstra, Dirk Wybe Grijpma
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Publication number: 20150004216Abstract: A medicant composition is provided. The composition includes a film layer and a powder matrix layer. The powder matrix layer includes a medicant. The powder matrix layer is applied to the film layer by admixing particulate to form a powder matrix and by then applying the powder matrix to the film layer by any desired method. The composition of the powder matrix is varied to alter the dissolution rate of the medicant, the adhesion of the medicant composition, and other physical properties of the powder matrix. The powder matrix layer can be cured.Type: ApplicationFiled: September 19, 2014Publication date: January 1, 2015Inventor: Robert Steven Davidson
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Publication number: 20140364391Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.Type: ApplicationFiled: June 6, 2014Publication date: December 11, 2014Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA, NORTHWESTERN UNIVERSITYInventors: Ton That Hai, John-Bruce Devault Green, Timothy Michael Fulghum, Phillip Byron Messersmith, Tadas Stanislovas Sileika
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Publication number: 20140364418Abstract: A topical composition providing reduced irritation that contains aromatic alcohols such as phenoxyethanol and a TRPV-1 antagonist is described. The composition is substantially free of parabens. The composition may be used for example for cleansing the skin.Type: ApplicationFiled: May 15, 2014Publication date: December 11, 2014Applicant: Johnson & Johnson Consumer Companies, Inc.Inventors: Slawomir Cebulski, Michelle Garay, Karien J. Rodriguez, Michael D. Southall, Simarna Kaur
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Publication number: 20140336163Abstract: The invention relates to injectable pharmaceutical compositions, methods of use and formulation, wherein the compositions comprise: one or more water soluble complexes, each complex comprising a cyclodextrin or a cyclodextrin derivative and a hydrophobic drug; at least one preservative; and at least one co-solvent. The compositions are effectively preserved in accordance with the European Pharmacopoeia 2011 Test for Efficacy of Antimicrobial Preservation, satisfying at least the B criteria as it applies to parenterals, and the United States Pharmacopeia 2011 Guidelines for Antimicrobial Effectiveness Testing, satisfying the criteria for Category 1 (injectable) products.Type: ApplicationFiled: November 27, 2012Publication date: November 13, 2014Inventors: Kirby Shawn Pasloske, Kai Lau, Sarah Jane Richardson, Amanda Aileen Willis
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Publication number: 20140336271Abstract: Compositions having a combination of carvacrol and thymol are found to have synergistic antimicrobial activity against feed pathogens.Type: ApplicationFiled: May 7, 2014Publication date: November 13, 2014Inventors: Sally Moore, Mitchell Poss
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Publication number: 20140322079Abstract: A synergistic microbicidal composition containing a selected from the class consisting of chlorinated phenols, fused bicyclic phenols, monosubstituted phenols and monosubstituted catechols and an antimicrobial alcohol selected from the class consisting of acyclic terpene alcohols.Type: ApplicationFiled: December 5, 2012Publication date: October 30, 2014Applicant: ROHM AND HAAS COMPANYInventors: Robert J. Cornmell, Megan A. Diehl, Stephen Golding, John R. Harp, Ian P. Stott, Katherine M. Thompson, Carol L. Truslow
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Publication number: 20140323587Abstract: The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.Type: ApplicationFiled: December 19, 2013Publication date: October 30, 2014Applicants: PALADIN LABS INC., PALADIN LABS (BARBADOS) INC., PALADIN LABS EUROPE LIMITEDInventors: Francois Ravenelle, Sandra Gori, David Lessard, Laibin Luo, Dorothee Le Garrec, Damon Smith
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Patent number: 8865032Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.Type: GrantFiled: August 13, 2013Date of Patent: October 21, 2014Assignee: Soft Gel Technologies, Inc.Inventor: Michael Fantuzzi
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Patent number: 8859508Abstract: The present invention relates to the application of 5-methyl-1,3-benzenediol or its derivatives represented by Formula I; wherein the constituent variables are as defined herein or pharmaceutical compositions thereof containing them in the preparation of medicines or functional foods. The present studies indicate that 5-methyl-1,3-benzenediol or its derivatives represented by Formula I, wherein the constituent variables are as defined herein or pharmaceutical compositions thereof containing them show more significant antidepressant effects than fluoxetine or imipramine.Type: GrantFiled: July 25, 2008Date of Patent: October 14, 2014Assignees: Kunming Institute of Botany, Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Jingbiao Biosciences R&D Co., Ltd.Inventors: Jijun Chen, Lin Xu, Jun Zhou, Jun Lu, Rongrong Mao, Meng Tian, Qixin Zhou, Xuemei Zhang, Yong Shen, Zhiyong Jiang, Aixue Zuo
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Publication number: 20140302169Abstract: A method wherein subjects having or at risk for having hyperopia, presbyopia or astigmatism are administered a composition having an effective amount of ocular antioxidants, including specifically macular pigments, to prevent, treat, or delay the onset of age-related macular degeneration (AMD).Type: ApplicationFiled: June 18, 2014Publication date: October 9, 2014Inventor: Richard Roberts
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Patent number: 8853264Abstract: The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a method for preventing or treating an inflammatory disease, comprising administering to a subject in need thereof an effective amount of macelignan represented by Chemical Formula I or a pharmaceutically acceptable salt thereof. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE2, COX-2 and TNF-? and by treating or preventing inflammatory disease in vivo. Accordingly, the lignan compound or a Myristica fragrans extract will be highly useful for the treatment or prevention of an inflammatory disease.Type: GrantFiled: April 23, 2010Date of Patent: October 7, 2014Assignees: Newtree Industry Co., Ltd.Inventors: Jae-Kwan Hwang, Do-Un Kim, Jae-Youn Chung, Hee-Chul Chung, Kyu-Lee Han
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Publication number: 20140294980Abstract: Particles for delivery of active ingredients formed from an active ingredient and a hydrophobic matrix, as well as methods for making such particles.Type: ApplicationFiled: June 12, 2014Publication date: October 2, 2014Inventors: Cory Berkland, Milind Singh
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Patent number: 8841348Abstract: Compositions containing apocynin and paeonol. The compositions may be used for the treatment of inflammatory diseases.Type: GrantFiled: April 7, 2006Date of Patent: September 23, 2014Assignee: AKL Inflammatory LimitedInventor: Nicholas John Larkins
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Patent number: 8841264Abstract: Compositions containing a combination of hydroxytyrosol and resveratrol or liqustilide or (?)-epigallocatechin gallate or honokiol or genistein or Magnolia bark extract or a combination of oleuropein and resveratrol or ligustilide are used to treat inflammatory disorders.Type: GrantFiled: July 12, 2007Date of Patent: September 23, 2014Assignee: DSM IP Assets B.V.Inventors: Daniel Raederstorff, Nathalie Richard, Joseph Schwager, Karin Wertz
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Publication number: 20140256830Abstract: Provided herein are methods and compositions comprising resorcinol derivatives for the use of treating, regulating or preventing a skin condition characterized by oxidative stress or a degenerative process. Methods of preventing, lightening or reducing the appearance of visible discontinuities of the skin resulting from skin pigmentation, skin aging, or other disorders are also disclosed.Type: ApplicationFiled: March 6, 2014Publication date: September 11, 2014Inventors: Andrew W. HINMAN, Dana Davis, Viktoria Kheifets
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Publication number: 20140256826Abstract: The present document describes a method of reducing a microbial presence on at least one part of a subject by topically contacting the subject's part with an antimicrobial formulation comprising: a) at least one antimicrobial isolated or synthetic phenolic compound of natural origin; b) at least one surfactant sufficient to form a solution or dispersion of said phenolic compound in an aqueous carrier; c) a solvent for dissolving said phenolic compound; and d) a sufficient aqueous carrier quantity to make 100% (w/w).Type: ApplicationFiled: March 8, 2013Publication date: September 11, 2014Applicant: Laboratoire M2Inventors: Gaetan LEMIRE, Ulysse DESRANLEAU DANDURAND, Sylvain QUESSY, Ann LETELLIER
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Publication number: 20140242138Abstract: Method for the preparation of microencapsulated essential oils or a formulation thereof for various non-agricultural applications.Type: ApplicationFiled: May 7, 2014Publication date: August 28, 2014Applicant: BOTANOCAP LTD.Inventors: Amnon Kritzman, Arie Markus, Pnina Strongin, Charles Linder
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Publication number: 20140243423Abstract: Described herein are methods and compositions for increasing the efficacy and decreasing the irritancy of topical formulations of hydroquinone.Type: ApplicationFiled: February 27, 2013Publication date: August 28, 2014Applicant: Precision Dermatology, Inc.Inventors: Ronald M. Gurge, Mark W. Trumbore, Nupoor Devrajbhai Hirani
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Patent number: 8809311Abstract: A process for improving the health of a subject, the process comprising orally administering a composition comprising hydroxytyrosol to the subject to provide the subject with a daily dose of about 0.1 to about 750 ?g hydroxytyrosol per kg of body weight, and a dietary supplement in dosage unit form for oral administration, the dosage unit form comprising a composition containing about 1 microgram to about 50 milligrams hydroxytyrosol or an ester or salt thereof.Type: GrantFiled: August 10, 2010Date of Patent: August 19, 2014Inventor: Darlene McCord
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Publication number: 20140228306Abstract: A method of making a facile, surface-independent, polyphenol coating is disclosed. In general, the method includes contacting at least a portion of the substrate to be coated with an aqueous solution containing one or more salts and one or more nitrogen-free phenolic compounds. Substrates of all kinds may be used, and compounds used to make the coating may include epigallocatechin-3-gallate (EGCG), epigallocatechin (EGC) and epicatechin-3-gallate (ECG), tannic acid, gallic acid, pyrogallol, and/or other nitrogen-free phenolic compounds. The coating made using the method, methods of using the coating, and kits comprising the coating precursors are also disclosed.Type: ApplicationFiled: February 24, 2014Publication date: August 14, 2014Inventors: Phillip B. Messersmith, Tadas S. Sileika, Ran Zhang, Devin G. Barrett
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Publication number: 20140227239Abstract: It is an object of the present invention to provide a growth hormone secretagogue that is excellent in effect of promoting secretion of a growth hormone and is orally available. The growth hormone secretagogue of the present invention contains one or more selected from the group consisting of S-adenosylmethionine and/or a salt thereof, a Siberian larch extract, an olive extract, and a stilbene-based compound as an active ingredient. S-adenosylmethionine and/or the salt thereof may be a form itself of chemically synthesized S-adenosylmethionine and/or the salt thereof, or may be a microbial cell or a culture containing S-adenosylmethionine and/or the salt thereof. The stilbene-based compound may be an extract extracted from a Vitaceae plant or a Gnetaceae plant. The olive extract may be an extract separated from a fruit of olive.Type: ApplicationFiled: March 2, 2012Publication date: August 14, 2014Applicant: LION CORPORATIONInventors: Toshio Gokita, Ikuko Kamada, Kiwamu Suzuki, Hiroaki Kambayashi
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Patent number: 8802734Abstract: Compounds for use in the treatment or prophylaxis of pain, including acute and chronic pain (e.g., nociceptive pain, neuropathic pain, headaches, migraine), represented by general formula I: in which: the dotted line represents a single or a double bond; and R5 and R5? are independently —H, —OH or —OR6, where R6 is a linear or branched C1-C4 alkyl; X is —CH2O—; Z is —CH2CH2O—, —CH(CH3)CH2O— or —CH2CH(CH3)O—; m is 1; and n is an integer of 1-5. The compounds of the invention are also effective for reducing inflammation and may be used alone or in combination with other analgesics.Type: GrantFiled: September 9, 2010Date of Patent: August 12, 2014Assignee: Novaremed LimitedInventor: Eliahu Kaplan
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Patent number: 8802737Abstract: A method for improving tetracycline-resistance of A. baumannii, by providing a ginger compound combined with tetracycline to against A. baumannii infection, wherein the ginger compound comprises [6]-dehydrogingerdione, [6]-shogaol and [6]-gingerol or [10]-gingerol, [6]-shogaol and [6]-gingerol.Type: GrantFiled: September 17, 2013Date of Patent: August 12, 2014Assignee: Kaohsiung Medical UniversityInventors: Yen-Hsu Chen, Hui-Min Wang, Chung-Yi Chen, Hsi-An Chen, Wei-Ru Lin
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Patent number: 8796340Abstract: The invention provides novel pharmaceutical compositions comprising the active ingredient propofol. Preferably, propofol is dissolved in at least one semifluorinated alkane. The compositions, which are preferably liquid or gel-like, may optionally comprise further excipients. They may be used as fill material in capsules, as buccal or nasal sprays, or as aerosols for pulmonary administration. They are particularly useful for the transmucosal administration of propofol.Type: GrantFiled: November 22, 2010Date of Patent: August 5, 2014Assignee: Novaliq GmbHInventors: Bastian Theisinger, Sonja Theisinger
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Patent number: 8796315Abstract: The present disclosure relates to compositions for and methods of improving wound healing, including compositions for and methods of treating chronic wounds, and compositions for the inhibition and treatment of necrosis and extended quiescence that result in cellular necrosis instead of normal proliferation. The methods for wound healing administer one or more compositions including hydroxytyrosol and oleuropein with cells derived from umbilical cord blood.Type: GrantFiled: March 15, 2013Date of Patent: August 5, 2014Inventor: Darlene E. McCord
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Publication number: 20140206773Abstract: A (?)-stereoisomer of formula (I): wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.Type: ApplicationFiled: September 23, 2013Publication date: July 24, 2014Applicant: Signature Therapeutics, Inc.Inventor: Thomas E. Jenkins
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Publication number: 20140206630Abstract: A method of making a facile, surface-independent, polyphenol coating is disclosed. In general, the method includes contacting at least a portion of the substrate to be coated with an aqueous solution containing one or more salts and one or more nitrogen-free phenolic compounds. Substrates of all kinds may be used, and compounds used to make the coating may include epigallocatechin-3-gallate (EGCG), epigallocatechin (EGC) and epicatechin-3-gallate (ECG), tannic acid, gallic acid, pyrogallol, and/or other nitrogen-free phenolic compounds. The coating made using the method, methods of using the coating, and kits comprising the coating precursors are also disclosed.Type: ApplicationFiled: January 23, 2014Publication date: July 24, 2014Inventors: Phillip B. Messersmith, Tadas S. Sileika, Ran Zhang, Devin G. Barrett
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Patent number: 8785471Abstract: Preparation and usage of a pharmaceutical composition containing ferulic acid and matrine compounds are described. The ingredients ferulic acid and matrine compounds in this pharmaceutical composition have synergistic effects which can obviously improve the pharmacology effects of both the ferulic acid and matrine compounds. Moreover, the pharmaceutical composition can significantly increase the aqueous and fat solubility of the individual ingredients.Type: GrantFiled: September 9, 2009Date of Patent: July 22, 2014Assignee: Qingdao Qiyuan Bio-Technologies Co., Ltd.Inventors: Xiaojie Sun, Weifu Ma
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Patent number: 8785504Abstract: A compound of the general formula (I) is provided for use in the topical treatment of infection, inflammation and/or pain: wherein R1 independently represents a methylene group, an ethylene group or a straight or branched chain C3 to C6 alkylene group; R2 independently represents a hydrogen atom, a methyl group, an ethyl group or a straight or branched chain C3 to C20 alkyl group; x represents 0 or an integer from 1 to 4 and y represents 0 or an integer from 1 to 4, wherein the sum of x and y is 4; and Z represents a hydrogen atom or (HOR1)yR2xN+; compositions including the compound; use of the compound in the manufacture of a medicament; and methods of medical treatment including the topical application of the compound.Type: GrantFiled: June 12, 2008Date of Patent: July 22, 2014Inventor: Roy Arlington Jordan
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Publication number: 20140194531Abstract: Hydroxytyrosol or olive juice containing hydroxytyrosol ca in can he used to maintain or increase mitochondria(biogenesis in cardiac muscle, skeletal muscles, and liver tissue.Type: ApplicationFiled: January 6, 2014Publication date: July 10, 2014Applicant: DSM IP Assets B.V.Inventors: Jiankang LIU, Daniel RAEDERSTORFF, Ying WANG-SCHMIDT, Karin WERTZ
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Patent number: 8765794Abstract: The present disclosure relates to compositions for and methods of repairing the stratum corneum, compositions and methods for inhibiting excessive transepidermal water loss, compositions for and methods of treating skin that is distressed or wounded as a result of a disease or other biological condition or process (as distinguished from wounds resulting from trauma), compositions for and methods of treating chronic wounds, and compositions for the inhibition and treatment of necrosis and extended quiescence that result in cellular necrosis instead of normal proliferation.Type: GrantFiled: June 25, 2010Date of Patent: July 1, 2014Inventor: Darlene McCord
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Publication number: 20140178314Abstract: Personal care compositions for use in an absorbent article are disclosed comprising an isosorbide diester having the formula: wherein R? and R? are independently selected from a straight or branched C1-30 chain, which may be saturated or unsaturated. The personal care compositions also comprise a solid cosmetic active soluble in the isosorbide diester and a dermatologically acceptable carrier. The personal care composition may be in the form of an emulsion. A personal care composition is also disclosed comprising an isosorbide diester having the formula: wherein R? and R? are independently selected from a straight or branched C1-30 chain which may be saturated or unsaturated and Z1-Z6 are independently selected from hydrogen, hydroxyl, amino, amido, R?, or R?. Methods of making the aforementioned personal care compositions are also disclosed.Type: ApplicationFiled: December 16, 2013Publication date: June 26, 2014Applicant: The Procter & Gamble CompanyInventors: Paul Robert Tanner, Larry Richard Robinson
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Patent number: 8759404Abstract: The invention discloses a stable intravenous Propofol oil-in-water emulsion composition having mixed preservatives of low toxicity that is capable of withstanding accidental contamination of bacteria and fungi. The preservative system employed comprising of monoglyceryl ester of lauric acid (Monolaurin) and a member selected from (a) capric acid and/or its soluble alkaline salts or its monoglyceryl ester (Monocaprin); (b) edetate; and (c) capric acid and/or its soluble alkaline salts or its monoglyceryl ester (Monocaprin) and edetate.Type: GrantFiled: March 2, 2007Date of Patent: June 24, 2014Assignee: Bharat Serums & Vaccines Ltd.Inventors: Gautam Vinod Daftary, Srikanth Annappa Pai, Girish Narasimha Shanbhag, Sangeeta Hanurmesh Rivankar
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Publication number: 20140170195Abstract: A powder comprising core/shell particles having an average particle size of less than 1000 microns, each particle comprising: 1) a liquid core that is substantially free of water and comprises a polar liquid having a percent surface polarity of at least 24%, and 2) a shell comprising hydrophobic particles, is provided.Type: ApplicationFiled: January 8, 2014Publication date: June 19, 2014Applicant: Johnson & Johnson Consumer Companies, Inc.Inventors: Ali Fassih, Ying Sun
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Publication number: 20140170198Abstract: The present invention relates to compositions comprising terpenes which are particularly suitable for treating plant infections, to methods of making such compositions, and to methods of using them. The present invention also relates to compositions comprising terpenes and hollow glucan particles or cell wall particles and methods for preparing such compositions; such compositions increase terpene stability and activity and provide a suitable carrier for the terpenes. The invention also relates to methods of using such compositions in the medical, veterinary and agricultural fields. In particular, the terpenes disclosed are thymol, eugenol, geraniol, citral and L-carvone.Type: ApplicationFiled: February 25, 2014Publication date: June 19, 2014Applicant: Eden Research PLCInventors: Lanny Franklin, Gary Ostroff