Aftertreated Solid Synthetic Organic Polymer (e.g., Grafting, Blocking, Etc.) Patents (Class 514/772.1)
  • Patent number: 10849843
    Abstract: A cosmetic ink composition comprises a particulate material, a (meth)acrylic acid homopolymer or salt thereof, and a rheology modifier. The particulate material can have a Particle Size Distribution D50 of about 100 nm to about 2,000 nm. The (meth)acrylic acid homopolymer or salt thereof can have a weight average molecular weight of less than about 20,000 daltons. The rheology modifier can be selected from the group consisting of alkali swellable emulsion polymers, hydrophobically modified alkali swellable emulsion polymers, and combinations thereof. The cosmetic ink composition can have a first dynamic viscosity of greater than about 1,100 cP at a shear rate of 0.1 sec?1 measured at 25° C. and a second dynamic viscosity of less than about 100 cP at a shear rate of 1,000 sec?1 measured at 25° C.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: December 1, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Janette Villalobos Lingoes, Thomas Elliot Rabe, Matthew Joseph Linser, Ajay Suthar
  • Patent number: 10835482
    Abstract: A composition (d) includes (per 100% of its weight): a) 90 wt.-% to 99.0 wt.-% water including, in dissolved form, 0.002 mol/L to 0.1 mol/L of at least one salt of ammonium cation or of a monovalent or multivalent metal cation with an organic or inorganic anion; b) 0.5 wt.-% to 5 wt.-% of at least one crosslinked anionic polyelectrolyte; and c) 0.5 wt.-% to 5 wt.-% of at least one compound having formula (II), where the weight ratio of the crosslinked anionic polyelectrolyte to the compound of formula (II) is greater than or equal to 0.2 and less than or equal to 2.0, and the molar ratio of the compound of formula (II) to the salt is greater than or equal to 0.05 and less than or equal to 1. Also disclosed is the composition in cosmetics and to a method for lightening the thickened salt-rich composition.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: November 17, 2020
    Assignee: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC
    Inventors: Benoit Verdu, Cindy Sourdon, Alicia Roso
  • Patent number: 10813857
    Abstract: A cosmetic ink composition comprises a particulate material, a polymeric dispersant having a weight average molecular weight of less than about 20,000 daltons, and a polymeric rheology modifier. The particulate material can have a Particle Size Distribution D50 of about 100 nm to about 2,000 nm. The cosmetic ink composition can undergo controlled syneresis, forming a weak colloidal gel phase and a particle-lean, low viscosity phase, which can be printed without interventions such as agitation, mixing, or re-circulation to homogenize the composition.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: October 27, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Janette Villalobos Lingoes, Thomas Elliot Rabe, Jeremy Chang, Ajay Suthar
  • Patent number: 10794000
    Abstract: A method for manufacturing printed textiles includes the steps of: a) inkjet printing an image onto a textile substrate with one or more inkjet printing liquids containing thermally reactive composite resin particles in an aqueous medium; and b) fixing the inkjet printed image by applying directly and/or indirectly a heat treatment to the image; wherein the thermally reactive composite resin particles contain at least one thermal cross-linker and at least one polymeric resin containing functional groups suitable for reacting with the thermal cross-linker.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: October 6, 2020
    Assignee: AGFA NV
    Inventors: Lionel Petton, Johan Loccufier, Ellen Bertels
  • Patent number: 10786477
    Abstract: Novel active compositions having antimicrobial and anti-inflammatory activity are described, the activity provided by an active component prepared in a suspension, the active component being at least a single chain fatty acid having a carbon length of 12, or between 12 and no more than 18. The fatty acid may be esterified and/or ethylated or methylated. As an antimicrobial the active component has activity against one or more microorganisms including Staphylococcus spp., Streptococcus spp., Mycobacterium spp., Clostridium spp., and Candida spp., with an MIC as low as 0.0018 ?g/ml. As an anti-inflammatory, it is at least as or is more effective than cyclosporine in preventing T-cell proliferation in response to a trigger, such as stimulation by the one or more microorganisms. The active component is more active when combined with a phospholipid (e.g., lecithin, phosphatidylcholine) and caused to form liposomal nanoparticles. It is also more active when caused to form coated liposomal nanoparticles.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: September 29, 2020
    Assignee: Natureza, Inc.
    Inventors: Lynn S. James-Meyer, Gerald C. Coles
  • Patent number: 10479873
    Abstract: Provided is a method of producing a polymer-impregnated base resin which is excellent in providing low adsorption of proteins and blood cells such as platelets. The method of producing a polymer-impregnated base resin includes impregnating a base resin with a polymer solution that includes a solvent able to swell the base resin.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: November 19, 2019
    Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., KYUSHU UNIVERSITY, NATIONAL UNVIERSITY CORPORATION
    Inventors: Yasuhisa Minagawa, Keiji Tanaka, Hisao Matsuno, Toyoaki Hirata
  • Patent number: 10328095
    Abstract: A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting a plurality of oxidized cellulose microspheres into a lumen of a blood vessel to at least partially block the lumen.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 25, 2019
    Assignee: Covidien LP
    Inventors: Phillip Blaskovich, Rachit Ohri, Olga Cherniavsky
  • Patent number: 10328014
    Abstract: The invention relates to a cosmetic process for caring for the skin, more particularly facial skin, in particular wrinkled skin, comprising the topical application to the skin of a cosmetic composition comprising a grafted polysaccharide polymer (I) and exposure of the treated skin to light radiation, polymer (I) being of formula: PS—(CO—NH-L-X)a(COOH)b in which PS denotes the basic backbone of the polysaccharide bearing the carboxylic acid groups; L is a divalent hydrocarbon-based group containing from 1 to 20 carbon atoms; X denotes a photoactive group of azide or diazirine type; a denotes the content of COOH groups substituted with the group —NH-L-X; b denotes the content of unsubstituted free COOH groups; a being between 0.01 and 0.8; b being between 0.2 and 0.99; a+b=1 The invention also relates to the polymers (I) bearing a photoactive group X of diazirine type and to a composition comprising such a polymer in a physiologically acceptable medium.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: June 25, 2019
    Assignee: L'OREAL
    Inventor: Andrew Greaves
  • Patent number: 10285399
    Abstract: A dispensable hydroalcoholic gel composition is provided. The dispensable hydroalcoholic gel includes a C1-4 alcohol, a polyacrylate thickener, and a glyceryl ester.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: May 14, 2019
    Assignee: GOJO Industries, Inc.
    Inventors: David R. Macinga, Sarah L. Edmonds, Kristin E. Hartzell, Kelly A. Dobos, Carol A. Quezada
  • Patent number: 10278388
    Abstract: A dispensable gel composition is provided. The dispensable gel composition includes a C1-4 alcohol, a polyacrylate thickener, and a diol plug-preventing additive. The dispensable gel exhibits less misdirection during dispensing from a dispensing device than gel compositions that are otherwise identical, but for the presence of the plug-preventing additive.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: May 7, 2019
    Assignee: GOJO Industries, Inc.
    Inventors: David R. Macinga, Sarah L. Edmonds, Kristin E. Hartzell, Kelly A. Dobos, Carol A. Quezada
  • Patent number: 10271548
    Abstract: A dispensable gel composition is provided. The dispensable gel composition includes a C1-4 alcohol, a polyacrylate thickener, and a plug-preventing additive. The dispensable gel exhibits less misdirection during dispensing from a dispensing device than gel compositions that are otherwise identical, but for the presence of the plug-preventing additive.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: April 30, 2019
    Assignee: GOJO Industries, Inc.
    Inventors: David R. Macinga, Sarah L. Edmonds, Kristin E. Hartzell, Kelly A. Dobos, Carol A. Quezada
  • Patent number: 10258716
    Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological pH solution; wherein the biocompatible polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: April 16, 2019
    Assignee: MicroVention, Inc.
    Inventors: Gregory M. Cruise, Michael J. Constant, Edward Michael Keeley, Rob Greene, Clayton Harris
  • Patent number: 10130093
    Abstract: A dispensable gel composition is provided. The dispensable gel composition includes a C1-4 alcohol, a polyacrylate thickener, a diol plug-preventing additive, and one or more neutralizers. The one or more neutralizers are selected from sodium hydroxide, ammonium hydroxide, potassium hydroxide, arginine, tetrahydroxypropyl ethylenediamine, triethanolamine, tromethamine, and triisopropanolamine.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: November 20, 2018
    Assignee: GOJO Industries, Inc.
    Inventors: David R. Macinga, Sarah L. Edmonds, Kristin E. Hartzell, Kelly A. Dobos, Carol A. Quezada
  • Patent number: 10124077
    Abstract: Described herein are compositions and methods for cancer cell biomarkers, such as pancreatic ductal adenocarcinoma (PDAC) cell biomarkers, and binding molecules for diagnosis and treatment of cancer, e.g., PDAC. Methods of identifying “accessible” proteomes are disclosed for identifying cancer biomarkers, such as plectin-1, a PDAC biomarker. Additionally, imaging compositions are provided comprising magnetofluorescent nanoparticles conjugated to peptide ligands for identifying PDACs.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: November 13, 2018
    Assignee: The General Hospital Corporation
    Inventors: Kimberly Kelly, Ralph Weissleder, Nabeel Bardeesy
  • Patent number: 10118980
    Abstract: Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: November 6, 2018
    Assignee: Terumo Corporation
    Inventors: Steve Plotkin, Gregory M. Cruise, Edward Michael Keeley, Renee Yu, Clayton Harris
  • Patent number: 10064870
    Abstract: The present disclosure relates generally to sol-gel polymer composites that comprise chitosan, a hydrophilic polymer, a gelation agent, and optional additional ingredients in a suitable medium. Advantageously, the sol-gel polymer composite can form a durable seal or strong solid in response to one or more physiological stimulus. The disclosure further relates to medical and veterinary uses of the composite, particularly, methods and delivery systems for reducing or preventing the incidence of a mammary disorder in a dairy animal. More particularly, the disclosure includes methods and sol-gel polymer composite compositions for creating a physical barrier on the teat surface or in the teat canal or cistern of a non-human animal for prophylactic treatment of mammary disorders such as mastitis wherein the sol-gel polymer creates a seal in response to one or more physiological stimulus.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: September 4, 2018
    Assignee: Zoetis Services LLC
    Inventors: Sumitra Rajagopalan, Wilms Baille, Piotr Kujawa, Christopher A. Zook, Rebecca R. Quesnell, Dennis L. Huczek, Stephen L. Secreast, Laibin Luo, Tammy A. Sanders
  • Patent number: 10010585
    Abstract: Methods to reduce the proliferation of vestibular schwannoma (VS) cells and/or provide neuroprotection to reduce the risk of sensorineural hearing loss (SNHL), vestibular dysfunction and facial nerve paralysis in subjects with VS. The methods can include one or more of decreasing TNF-? activity or expression; decreasing NF-?B expression or activity; decreasing COX-2 expression or activity; administering FGF2; decreasing HGF expression or activity; or decreasing c-Met expression or activity.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: July 3, 2018
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Konstantina Stankovic, Sonam Dilwali
  • Patent number: 10004227
    Abstract: A dispensable hydroalcoholic gel composition is provided. The dispensable hydroalcoholic gel includes a C1-4 alcohol, a polyacrylate thickener, one or more neutralizers, and an additive. The dispensable hydroalcoholic gel exhibits less misdirection during dispensing from a dispensing device than gel compositions that are otherwise identical, but for the presence of the additive.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: June 26, 2018
    Assignee: GOJO Industries, Inc.
    Inventors: David R. Macinga, Sarah L. Edmonds, Kristin E. Hartzell, Kelly A. Dobos, Carol A. Quezada
  • Patent number: 9683148
    Abstract: An adhesive containing a block copolymer having at least one structure represented by formula: -[A1]-[B/A2]-, where [A1] represents a polymer block composed of a structural unit derived from a methacrylic acid ester (A1), [B/A2] represents a copolymer block composed of a structural unit derived from an acrylic acid ester (B) and a structural unit derived from a methacrylic acid ester (A2), and the copolymer block [B/A2] has a gradient copolymer block section in which a copolymerization ratio of the methacrylic acid ester (A2) continuously increases from a section connected to the polymer block [A1]. The block copolymer has a total content of the structural units derived from the methacrylic acid ester (A1) and the methacrylic acid ester (A2) of 5% to 60% by mass, a weight-average molecular weight (Mw) of 30,000 to 300,000, and a molecular weight distribution (Mw/Mn) of 1.0 to 1.5.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: June 20, 2017
    Assignee: KURARAY CO., LTD.
    Inventors: Kanayo Nakada, Yoshihiro Morishita
  • Patent number: 9532979
    Abstract: The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drugs lopinavir and ritonavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: January 3, 2017
    Assignee: The University of Liverpool
    Inventors: Marco Norman Giardiello, Thomas Oliver McDonald, Andrew Owen, Steven Paul Rannard, Philip John Martin, Darren Lee Smith
  • Patent number: 9498438
    Abstract: The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug efavirenz. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: November 22, 2016
    Assignee: The University of Liverpool
    Inventors: Marco Norman Giardiello, Thomas Oliver McDonald, Andrew Owen, Steven Paul Rannard, Philip John Martin, Darren Lee Smith
  • Patent number: 9402393
    Abstract: A method is provided for reducing the frequency of mis-directed output of hydroalcoholic gel from a dispenser. The hydroalcoholic gel includes at least 30 wt. % of a C1-4 alcohol, a polyacrylate thickener, and a plug-preventing additive that may be a C6-10 alkane diol. A method of reducing the formation of coagulated gel deposits, and dispensable hydroalcoholic gel compositions are also provided.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: August 2, 2016
    Assignee: GOJO INDUSTRIES, INC.
    Inventors: David R. Macinga, Sarah L. Edmonds, Kristin E. Hartzell, Kelly A. Dobos, Carol A. Quezada
  • Patent number: 9278137
    Abstract: The present invention relates to novel conjugates of active principles grafted to a polymer, to the nanoparticles comprising them, to their preparation and to their polymeric intermediates.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: March 8, 2016
    Assignees: SANOFI, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE PAUL SABATIER TOULOUSE III
    Inventors: Abderrhamane Amgoune, Didier Bazile, Fethi Bensaid, Didier Bourissou, Eric Didier, Stephanie Greco, Harivardhan Reddy Lakkireddy, Serge Sable, Michel Veillard
  • Patent number: 9259436
    Abstract: The present invention provides a method of treating a skin ailment including administering to a subject in need thereof, a therapeutically effective amount of a composition including (i) a primary diamine; (ii) a secondary aromatic diamine; (iii) a polyisocyanate; and (iv) optionally, a polyol. The present invention also provides a method of forming a skin bandage.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: February 16, 2016
    Assignee: Chesson Laboratory Associates, Inc.
    Inventors: Jerry S. Chesson, Timothy J. Romack, Lance L. Swick, David R. Terry
  • Patent number: 9180085
    Abstract: Novel inverse latices based on fatty alcohol ethers of formula R1—O—R2 (I) in which R1 and R2 represent, independently from one another, a linear or branched alkyl radical comprising from 5 to 18 carbon atoms; and cosmetic, dermocosmetic, dermopharmaceutical or pharmaceutical compositions comprising them.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: November 10, 2015
    Assignee: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC
    Inventors: Olivier Braun, Paul Mallo, Hervé Rolland
  • Patent number: 9078930
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 14, 2015
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kevin Sill, Tomas Vojkovsky, Adam Carie
  • Patent number: 9040060
    Abstract: The present invention provides a water soluble, non-peptidic polymer comprising two or more alkylene oxide-based oligomers linked together by hydrolytically degradable linkages such as carbonates. Typically, the oligomer portion of the polymer is an amphiphilic triblock copolymer having a central propylene oxide block or butylene oxide block positioned between two ethylene oxide blocks. The polymer can be hydrolytically degraded into oligomers under physiological conditions. In aqueous media, the polymer preferably forms thermally reversible, hydrolytically degradable hydrogels that can be used, for example, for drug delivery and related biomedical applications.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: May 26, 2015
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, J. Milton Harris, Xuan Zhao, William Dudley Battle, III, Xiaoming Shen
  • Patent number: 9034930
    Abstract: A biodegradable polymeric hydrogel composition including a component A and component B forming a ?-aminoester linkage such that the linkage results in gelation, wherein component A is water soluble polymer containing acrylate functionality and component B is a water soluble amine functionality useful for medical applications such as such as drug delivery, tissue engineering, and biomaterials and method of preparation thereof.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: May 19, 2015
    Assignee: Council of Scientific & Industrial Research
    Inventors: Hemant Ravindran Nair, Mohan Gopalkrishna Kulkarni
  • Patent number: 9034390
    Abstract: The present invention generally relates to anti-microbial formulations and methods of their use and production. The formulations of the present invention are effective as broad spectrum anti-bacterial agents with efficacy against both Gram-negative and Gram-positive bacteria, as anti-viral agents with efficacy against both enveloped and non-enveloped viruses, and as anti-fungal agents with efficacy against both vegetative and spore forms of microorganisms and against biofilms. The present invention includes anti-microbial compositions that have at least one surfactant, at least one acid, at least one peroxide (preferably hydrogen peroxide), peracetic acid, and water. The anti-microbial Formulations of the present invention may additionally contain an organic salt. The organic salt may be a salt of the same acid that is used in the Formulation or a salt of a different acid. Methods for production and use of the inventive compositions are disclosed.
    Type: Grant
    Filed: May 10, 2007
    Date of Patent: May 19, 2015
    Assignee: BIONEUTRAL LABORATORIES CORPORATION
    Inventor: Andrew Kielbania, Jr.
  • Patent number: 9023897
    Abstract: A biodegradable drug delivery compositions comprising a triblock copolymer containing a polyester and a polyethylene glycol and a diblock copolymer containing a polyester and an end-capped polyethylene glycol, as well as a pharmaceutically active principle is disclosed.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: May 5, 2015
    Assignee: MedinCell
    Inventor: Georges Gaudriault
  • Patent number: 9017644
    Abstract: The present invention relates to dendrimer compositions configured for treating inflammatory disorders and autoimmune disorders, and related methods of synthesis. Specifically, the present invention relates to methods for treating rheumatoid arthritis with PAMAM dendrimers having functional ligands configured for treating rheumatoid arthritis (e.g., therapeutic agents, pro-drugs, targeting agents, trigger agents, imaging agents) (e.g., methotrexate).
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: April 28, 2015
    Assignee: The Regents of the University of Michigan
    Inventors: James R. Baker, Jr., Larry A. Sternson, David Repp, Deborah Ladenheim
  • Publication number: 20150105476
    Abstract: The present invention relates to an O/W type cosmetic composition with improved formulation stability, and more particularly, to an O/W type cosmetic composition comprising a branched polymer having a lipophilic alkyl side chain and an anionic surfactant, as active ingredients for improving formulation stability.
    Type: Application
    Filed: December 18, 2014
    Publication date: April 16, 2015
    Inventors: Jung Yeob Jeong, Young So Kim, Sung Il Park, Youn Joon Kim, Sang Hun Han
  • Publication number: 20150098912
    Abstract: Described herein is a polyether polyamide block copolymer as well compositions and products containing the polyether polyamide block copolymer. Methods of making and using the copolymer, the compositions, and products are also described herein.
    Type: Application
    Filed: May 18, 2012
    Publication date: April 9, 2015
    Applicant: CRODA INTERNATIONAL PLC
    Inventors: Geng Lin, Nancy W. Harman
  • Publication number: 20150099638
    Abstract: Stabilization compositions for HIP emulsions are disclosed which include a combination of a Gemini surfactant, a sugar-derived compound and a hydrophobically modified polymer. HIP emulsions are disclosed which include the stabilizing composition. Amino-acid based Gemini surfactants may be employed in the stabilizing compositions.
    Type: Application
    Filed: October 6, 2014
    Publication date: April 9, 2015
    Inventors: Steve Cochran, Masashi Yamamoto, Daphne Benderly, Christine Lynn Lummer, Marie Yednak-Carpenter
  • Publication number: 20150099808
    Abstract: Amphiphilic copolymer, containing at least a hydrophilic chain segment (A) and a hydrophobic chain segment (B), wherein the hydrophilic chain segment (A) contains peptides and wherein the hydrophobic chain segment (B) contains acetal groups or orthoester groups. The hydrophilic chain segment (A) preferably contains glutamine/glutamic acid units or asparagines/aspartic acid units, making a biodegradable copolymer which can form a thermogel.
    Type: Application
    Filed: December 10, 2014
    Publication date: April 9, 2015
    Inventors: Jorge HELLER, Sebastien Jerome PIERRE, Mike Gerardus Wilhelmus DE LEEUW, Jeroen PIEPER
  • Patent number: 9000052
    Abstract: A perfuming composition capable of prolonging the release of a perfuming component into the surrounding environment when applied on a surface. This composition utilizes hydrophobic block copolymers in the presence of high amounts of ethanol. The invention also relates to consumer articles containing such compositions. It finally provides methods for the perfuming of a surface and a method for increasing the long-lastingness of a perfuming component using these compositions.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: April 7, 2015
    Assignee: Firmenich SA
    Inventors: Damien Berthier, Sébastien Lecommandoux, Isabelle Schmidt, Christophe Schatz
  • Publication number: 20150093444
    Abstract: Provided are a polycaprolactone-polyphosphate block copolymer, a liquid composite formed by the block copolymer, a nucleic acid preparation, preparation methods for the copolymer and the liquid composite, and the use of the copolymer and the liquid composite in a nucleic acid medicine delivery system. The block copolymer prepared using the present invention has good biocompatibility, low cytotoxicity, and good biodegradability. The micelles provided in the present invention self-assemble into nano-particles in an aqueous solution, and have good stability, biocompatibility, and biodegradability, and low cytotoxicity. The preparation method is simple, has high repeatability, as a vector can protect small nucleic acids such as siRNA from biodegradation, can combine with the scale effect of nano-particles, and can be used for treating different diseases. Additionally, bonding targeting groups enable specificity recognition of different cancer cells.
    Type: Application
    Filed: October 23, 2012
    Publication date: April 2, 2015
    Applicant: SUZHOU RIBO LIFE SCIENCE CO., LTD.
    Inventors: Hongyan Zhang, Jun Wang
  • Publication number: 20150093343
    Abstract: The present disclosure relates, according to some embodiments, to methods of formulating a personal care product (e.g. sunscreen) composition that is stable when exposed to high and/or low temperatures for extended periods and that applies clear to wet skin and remains clear. A method may comprise, for example, combining a discontinuous oil phase with an emulsifying compound and one or more UV filters to form an oil phase mixture; heating and mixing the oil phase mixture; dispersing one or more non-emulsifying grade carbomer polymers in a continuous water phase to form a water phase mixture; combining and mixing the oil phase mixture and the water phase mixture to form a pre-emulsion; adding a neutralizing base to form a personal care product emulsion; adding water (e.g., to replace water lost during processing); and mixing the emulsion to form a homogenous composition. The present disclosure relates, in some embodiments, to compositions (e.g., stable compositions) for topical application to human skin (e.g.
    Type: Application
    Filed: September 30, 2014
    Publication date: April 2, 2015
    Inventors: Craig A. Bonda, Qing Jean Zhang
  • Publication number: 20150082750
    Abstract: The present invention is directed to wetting agent compositions and methods for making and using the wetting agent compositions. The compositions of the invention include a sheeting agent, a defoaming agent, and an association disruption agent. The wetting agent compositions of the present invention result in a faster draining/drying time on most substrates compared to conventional wetting agents. The wetting agent compositions of the present invention are especially suitable for use on plastic substrates.
    Type: Application
    Filed: November 25, 2014
    Publication date: March 26, 2015
    Inventors: Victor Fuk-Pong Man, Janel Marie Kieffer, Michael Charles Denoma, Yvonne Marie Killeen, Joshua P. Magnuson
  • Patent number: 8986728
    Abstract: The present invention provides an implantable device having a biosoluble coating or a biosoluble body structure comprising a polyelectrolyte and a counterion and the methods of making and using the same.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: March 24, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Syed F. A. Hossainy, Mikael O. Trollsas, Lothar W. Kleiner
  • Patent number: 8980238
    Abstract: Because of the formation of disulfide bridges with mucus glycoproteins, the mucoadhesive properties of polymeric compounds can be significantly improved by the covalent attachment of thiol substructures to them. By the transformation of free thiol groups on such polymers in disulfides with mercaptonicotinamides or mercaptopyridoxins these thiol groups become comparatively more reactive resulting in significantly improved mucoadhesive properties. Furthermore, polymers exhibiting disulfide partial structures with mercaptonicotinamides or mercaptopyridoxins do not need to be protected against oxidation. In addition, they show comparatively higher permeation enhancing properties.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: March 17, 2015
    Assignees: Thiomatrix Forschungs—Und Beratungs GmbH, Croma Pharma GmbH
    Inventor: Johannes Leierer
  • Patent number: 8980957
    Abstract: The subject invention relates to a method of preparing a biocompatible polymer comprising epsilon-linked L-lysine having free alpha-amino and carboxy functions. The invention further encompasses the resulting biocompatible polymer and articles made from the polymer, in particular contact and intraocular lenses.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: March 17, 2015
    Assignee: CIS Pharma AG
    Inventors: Rolf Schäfer, Hans Hitz
  • Publication number: 20150073020
    Abstract: Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, which composition has a surface tension of 40 dynes/cm or less and has continuing spreadability, and which composition is effective in treating a disorder of the nail or nail bed.
    Type: Application
    Filed: September 19, 2014
    Publication date: March 12, 2015
    Inventors: Gareth Winckle, Gregory T. Fieldson
  • Publication number: 20150071864
    Abstract: A reversely thermo-reversible hydrogel composition comprising a water soluble block copolymer comprising at least two blocks of polyethylene oxide and at least one block of polypropylene oxide, and at least one associative gelling adjuvant having water solubility less than 0.5 g/100 ml, preferably less than 0.3 g/100 ml at 20° C., and being capable of forming water soluble inter-molecular complexes with the water soluble block copolymer in water. The hydrogel composition exhibits improved gelling efficiency, enhanced solubility and/or stability for water sparely soluble and insoluble pharmaceutical agents. The hydrogel compositions are useful in a variety of pharmaceutical and cosmetic products and applications, such as esophageal, otic, vaginal, rectal, ophthalmic, treatments of disorders and imperfections of the skin, and treating and/or preventing alopecia and restoring and/or promoting hair growth.
    Type: Application
    Filed: September 22, 2014
    Publication date: March 12, 2015
    Applicant: Broda Technologies Co., Ltd.
    Inventors: Shao Xiang LU, Jeffrey LU, Letian LIU
  • Publication number: 20150071860
    Abstract: A micelle comprising a diblock polymer with a cyclic polyethylene glycol block and a hydrophobic block is provided. The micelle may be used in conjunction with one or a combination of therapeutic agents, targeting agents, and imaging agents. The micelle may be incorporated in a pharmaceutical composition.
    Type: Application
    Filed: September 9, 2014
    Publication date: March 12, 2015
    Inventors: Coleen Pugh, Gladys R. Montenegro-Galindo
  • Publication number: 20150073059
    Abstract: Organopolysiloxane gels produced by crosslinking an unsaturated organopolysiloxane resin with a crosslinking agent in the presence of a diluent have excellent sensory properties such as properties desirable in a variety of cosmetics products.
    Type: Application
    Filed: April 11, 2013
    Publication date: March 12, 2015
    Inventors: Sebastian Knoer, Aroop Kumar Roy
  • Publication number: 20150065586
    Abstract: The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.
    Type: Application
    Filed: November 14, 2014
    Publication date: March 5, 2015
    Inventor: Rao S. Bezwada
  • Publication number: 20150057367
    Abstract: Micro-sized particles having a polymeric structure of cells are provided. Also provided is a method of producing micro-sized particles having a polymeric structure comprising: (1) forming a homogenous solution by heating a mixture of a high molecular weight polymer and a low molecular weight material, wherein said low molecular weight material makes up at least about 50% by weight of the homogenous solution, (2) forming a dispersed solution by dispersing the homogenous solution formed in step (1) into an inert material, (3) cooling the dispersed solution to cause the high molecular weight polymer to phase separate from the low molecular weight material, (4) forming solid particles comprised of said low molecular weight material trapped inside a structure of cells of said high molecular weight polymer, and (5) removing the solid particles from the dispersed solution.
    Type: Application
    Filed: September 1, 2014
    Publication date: February 26, 2015
    Inventors: Xiaorong Wang, Mindaugas Rackaitis, Naruhiko Mashita, Victor Foltz
  • Patent number: 8962008
    Abstract: The present invention relates to a novel polymeric material with enhanced hydrophilicity for medical use comprising a biocompatible polyester material selected from the group consisting of poly(hydroxyalkanoate)s, poly(lactic acid)s, poly(glycolic acid)s, poly(caprolactone)s and copolymers and blends thereof, wherein the biocompatible polyester material is crosslinked with a functionalized poly(alkylene oxide) having at least two functional groups independently selected from the group consisting of azido-formate and alkanoyl azide. The novel polymeric material with enhanced hydrophilicity is useful as a biocompatible material in a variety of medical applications, including medical implants, bioresorbable implants, tissue engineering, and controlled release.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: February 24, 2015
    Assignees: Technische Universitat Graz, Medical University of Graz MUG, AT&S Austria Technologie & Systemtechnik Aktiengesellschaft, Herabus Medical GmbH
    Inventors: Frank Wiesbrock, Clemens Ebner, Franz Stelzer, Annelie-Martina Weinberg, Klaus-Dieter Kühn
  • Publication number: 20150045451
    Abstract: The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.
    Type: Application
    Filed: August 7, 2014
    Publication date: February 12, 2015
    Inventors: Durgadas Bolikal, Joachim B. Kohn, Lioubov Kabalnova