Abstract: The present invention provides a biodegradable drug delivery composition comprising: (i) a mixture of at least three different block copolymers, wherein each block copolymer is: (a) a biodegradable triblock copolymer having the formula: Av-Bw-Ax wherein A is a polyester and B is polyethylene glycol and v and x are the number of repeat units from 1 to 3,000 and w is the number of repeat units from 3 to 300 and v=x or v?x; or (b) a biodegradable diblock copolymer having the formula: Cy-Az wherein A is a polyester and C is an end-capped polyethylene glycol and y and z are the number of repeat units with y=2 to 250 and z=1 to 3,000; and wherein the mixture comprises at least one (a) and at least one (b); and the weight ratio between (a) and (b) is 1:19 to 5:1; and (ii) at least one pharmaceutically active ingredient.

Abstract: Provided herein are methods for determining the serotype of a virus particle and/or or determining the heterogeneity of a virus particle (e.g., an AAV particle). In other embodiments, the invention provides methods to determine the heterogeneity of AAV particles. In some aspects, the invention provides viral particles (e.g., rAAV particles) with improved stability and/or improved transduction efficiency by increasing the acetylation and/or deamidation of capsid proteins.

Abstract: Provided is a biodegradable drug delivery composition comprising: (i) a mixture of at least three different block copolymers, wherein each block copolymer is: (a) a biodegradable triblock copolymer having the formula: Av-Bw-Ax wherein A is a polyester and B is polyethylene glycol and v and x are from 1 to 3,000 and w is from 3 to 300 and v=x or v?x; or (b) a biodegradable diblock copolymer having the formula: Cy-Az wherein A is a polyester and C is an end-capped polyethylene glycol and y=2 to 250 and z=1 to 3,000; and wherein the mixture comprises at least one (a) and at least one (b); and the weight ratio between (a) and (b) is 1:19 to 5:1; and for at least one of the copolymers according to (a) or (b) A is poly(lactic-co-glycolic acid) (PLGA); and (ii) at least one pharmaceutically active ingredient.

Abstract: The present invention provides a biodegradable drug delivery composition comprising a mixture of at least two block copolymers taken among triblock and diblock copolymers comprising: (a) a biodegradable triblock copolymer having the formula: Av-Bw-Ax wherein A is a polyester and B is polyethylene glycol and v and x are from 1 to 3,000 and w is from 3 to 300 and v=x or v?x; (b) a biodegradable diblock copolymer having the formula: Cy-Az wherein A is a polyester and C is an end-capped polyethylene glycol and y and z are the number of repeat units with y=2 to 250 and z=1 to 3,000; wherein the weight ratio between (a) and (b) is 1:19 to 5:1; and for at least one of the copolymers according to (a) or (b) A is poly(?-caprolactone-co-lactide); and (c) at least one pharmaceutically active ingredient.

Abstract: The present invention relates to compositions and methods for the delivery of agents to a subject, particularly to the central nervous system (CNS).

Abstract: The present invention relates to a transdermal nano-carrier and, more specifically, to a nano-carrier having a chitosan-based nano-sponge structure. According to the present invention, as a nano-carrier having enhanced transdermal delivery on the basis of a complex containing chitosan is provided, it is possible to effectively deliver drugs, cosmetic materials, etc. into the skin.

Abstract: Organopolysiloxane gels containing a hydrocarbon diluent and non-chemically bonded natural oils are prepared by the hydrosilylative gelling of a mixture of an aliphatically unsaturated organopolysiloxane, an Si—H-functional organopolysiloxane, and a long chain ?-olefin, in the presence of a hydrocarbon diluent and at least one natural oil. Stable creamy gels are produced by shearing the gel product, and contain only a minor amount of crosslinked organopolysiloxane elastomeric component.

Abstract: According to the present disclosure, a bioadhesive formulation is provided. The bioadhesive formulation comprises a polycaprolactone dendrimer having a dendrimer core and a plurality of polycaprolactone chains extending from the dendrimer core, wherein at least one of the polycaprolactone chains has an end which is covalently attached with a diazirine, and wherein the diazirine converts to a carbene or a diazoalkyl when a stimulant is applied to the bioadhesive formulation. Methods of forming the bioadhesive formulation are also provided. The bioadhesive could be used in (i) the prevention of thrombosis from tissue fixation and/or (ii) the relief of discomfort and/or pain during and/or after surgery. Preferably, the bioadhesive formulation further comprises a hygroscopic additive, an antithrombotic agent, and/or an anaesthetic agent.

Abstract: Disclosed herein are methods of preparing thermoplastic gels and dry silicone gels with an alkyl ester polydimethylsiloxane having a formula (I): (I) Also disclosed are thermoplastic gels and dry silicone gels prepared by the disclosed methods. In the formula (I), n is about 60% to about 90% of the formula (I); m is about 10% to about 40% of the formula (I); R is —(C?O)—OR1; and R is a C2-C20 alkyl group. The alkyl ester polydimethylsiloxane has a weight average molecular weight of about 10,000 g/mol to about 50,000 g/mol. The hardness of the thermoplastic gels is less than 120 g peak load. The hardness of the dry silicone gels is less than 100 g peak load.

Abstract: Provided herein are compositions, devices, and systems comprising copolymers of an N-alkyl acrylamide residue and a polyester comprising citric acid, polyethylene glycol, and glycerol 1,3-diglycerolate diacrylate, and methods of use and manufacture thereof.

Abstract: The present disclosure relates to remediation of contaminated environmental sites. In particular, the present disclosure relates to passive control compositions and their use in remediation.

Abstract: A cosmetic ink composition comprises a particulate material, a (meth)acrylic acid homopolymer or salt thereof, and a rheology modifier. The particulate material can have a Particle Size Distribution D50 of about 100 nm to about 2,000 nm. The (meth)acrylic acid homopolymer or salt thereof can have a weight average molecular weight of less than about 20,000 daltons. The rheology modifier can be selected from the group consisting of alkali swellable emulsion polymers, hydrophobically modified alkali swellable emulsion polymers, and combinations thereof. The cosmetic ink composition can have a first dynamic viscosity of greater than about 1,100 cP at a shear rate of 0.1 sec?1 measured at 25° C. and a second dynamic viscosity of less than about 100 cP at a shear rate of 1,000 sec?1 measured at 25° C.

Abstract: A composition (d) includes (per 100% of its weight): a) 90 wt.-% to 99.0 wt.-% water including, in dissolved form, 0.002 mol/L to 0.1 mol/L of at least one salt of ammonium cation or of a monovalent or multivalent metal cation with an organic or inorganic anion; b) 0.5 wt.-% to 5 wt.-% of at least one crosslinked anionic polyelectrolyte; and c) 0.5 wt.-% to 5 wt.-% of at least one compound having formula (II), where the weight ratio of the crosslinked anionic polyelectrolyte to the compound of formula (II) is greater than or equal to 0.2 and less than or equal to 2.0, and the molar ratio of the compound of formula (II) to the salt is greater than or equal to 0.05 and less than or equal to 1. Also disclosed is the composition in cosmetics and to a method for lightening the thickened salt-rich composition.

Abstract: A cosmetic ink composition comprises a particulate material, a polymeric dispersant having a weight average molecular weight of less than about 20,000 daltons, and a polymeric rheology modifier. The particulate material can have a Particle Size Distribution D50 of about 100 nm to about 2,000 nm. The cosmetic ink composition can undergo controlled syneresis, forming a weak colloidal gel phase and a particle-lean, low viscosity phase, which can be printed without interventions such as agitation, mixing, or re-circulation to homogenize the composition.

Abstract: A method for manufacturing printed textiles includes the steps of: a) inkjet printing an image onto a textile substrate with one or more inkjet printing liquids containing thermally reactive composite resin particles in an aqueous medium; and b) fixing the inkjet printed image by applying directly and/or indirectly a heat treatment to the image; wherein the thermally reactive composite resin particles contain at least one thermal cross-linker and at least one polymeric resin containing functional groups suitable for reacting with the thermal cross-linker.

Abstract: Novel active compositions having antimicrobial and anti-inflammatory activity are described, the activity provided by an active component prepared in a suspension, the active component being at least a single chain fatty acid having a carbon length of 12, or between 12 and no more than 18. The fatty acid may be esterified and/or ethylated or methylated. As an antimicrobial the active component has activity against one or more microorganisms including Staphylococcus spp., Streptococcus spp., Mycobacterium spp., Clostridium spp., and Candida spp., with an MIC as low as 0.0018 ?g/ml. As an anti-inflammatory, it is at least as or is more effective than cyclosporine in preventing T-cell proliferation in response to a trigger, such as stimulation by the one or more microorganisms. The active component is more active when combined with a phospholipid (e.g., lecithin, phosphatidylcholine) and caused to form liposomal nanoparticles. It is also more active when caused to form coated liposomal nanoparticles.

Abstract: Provided is a method of producing a polymer-impregnated base resin which is excellent in providing low adsorption of proteins and blood cells such as platelets. The method of producing a polymer-impregnated base resin includes impregnating a base resin with a polymer solution that includes a solvent able to swell the base resin.

Abstract: A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting a plurality of oxidized cellulose microspheres into a lumen of a blood vessel to at least partially block the lumen.

Abstract: The invention relates to a cosmetic process for caring for the skin, more particularly facial skin, in particular wrinkled skin, comprising the topical application to the skin of a cosmetic composition comprising a grafted polysaccharide polymer (I) and exposure of the treated skin to light radiation, polymer (I) being of formula: PS—(CO—NH-L-X)a(COOH)b in which PS denotes the basic backbone of the polysaccharide bearing the carboxylic acid groups; L is a divalent hydrocarbon-based group containing from 1 to 20 carbon atoms; X denotes a photoactive group of azide or diazirine type; a denotes the content of COOH groups substituted with the group —NH-L-X; b denotes the content of unsubstituted free COOH groups; a being between 0.01 and 0.8; b being between 0.2 and 0.99; a+b=1 The invention also relates to the polymers (I) bearing a photoactive group X of diazirine type and to a composition comprising such a polymer in a physiologically acceptable medium.

Abstract: A dispensable hydroalcoholic gel composition is provided. The dispensable hydroalcoholic gel includes a C1-4 alcohol, a polyacrylate thickener, and a glyceryl ester.

Abstract: A dispensable gel composition is provided. The dispensable gel composition includes a C1-4 alcohol, a polyacrylate thickener, and a diol plug-preventing additive. The dispensable gel exhibits less misdirection during dispensing from a dispensing device than gel compositions that are otherwise identical, but for the presence of the plug-preventing additive.

Abstract: A dispensable gel composition is provided. The dispensable gel composition includes a C1-4 alcohol, a polyacrylate thickener, and a plug-preventing additive. The dispensable gel exhibits less misdirection during dispensing from a dispensing device than gel compositions that are otherwise identical, but for the presence of the plug-preventing additive.

Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological pH solution; wherein the biocompatible polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

Abstract: A dispensable gel composition is provided. The dispensable gel composition includes a C1-4 alcohol, a polyacrylate thickener, a diol plug-preventing additive, and one or more neutralizers. The one or more neutralizers are selected from sodium hydroxide, ammonium hydroxide, potassium hydroxide, arginine, tetrahydroxypropyl ethylenediamine, triethanolamine, tromethamine, and triisopropanolamine.

Abstract: Described herein are compositions and methods for cancer cell biomarkers, such as pancreatic ductal adenocarcinoma (PDAC) cell biomarkers, and binding molecules for diagnosis and treatment of cancer, e.g., PDAC. Methods of identifying “accessible” proteomes are disclosed for identifying cancer biomarkers, such as plectin-1, a PDAC biomarker. Additionally, imaging compositions are provided comprising magnetofluorescent nanoparticles conjugated to peptide ligands for identifying PDACs.

Abstract: Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.

Abstract: The present disclosure relates generally to sol-gel polymer composites that comprise chitosan, a hydrophilic polymer, a gelation agent, and optional additional ingredients in a suitable medium. Advantageously, the sol-gel polymer composite can form a durable seal or strong solid in response to one or more physiological stimulus. The disclosure further relates to medical and veterinary uses of the composite, particularly, methods and delivery systems for reducing or preventing the incidence of a mammary disorder in a dairy animal. More particularly, the disclosure includes methods and sol-gel polymer composite compositions for creating a physical barrier on the teat surface or in the teat canal or cistern of a non-human animal for prophylactic treatment of mammary disorders such as mastitis wherein the sol-gel polymer creates a seal in response to one or more physiological stimulus.

Abstract: Methods to reduce the proliferation of vestibular schwannoma (VS) cells and/or provide neuroprotection to reduce the risk of sensorineural hearing loss (SNHL), vestibular dysfunction and facial nerve paralysis in subjects with VS. The methods can include one or more of decreasing TNF-? activity or expression; decreasing NF-?B expression or activity; decreasing COX-2 expression or activity; administering FGF2; decreasing HGF expression or activity; or decreasing c-Met expression or activity.

Abstract: A dispensable hydroalcoholic gel composition is provided. The dispensable hydroalcoholic gel includes a C1-4 alcohol, a polyacrylate thickener, one or more neutralizers, and an additive. The dispensable hydroalcoholic gel exhibits less misdirection during dispensing from a dispensing device than gel compositions that are otherwise identical, but for the presence of the additive.

Abstract: An adhesive containing a block copolymer having at least one structure represented by formula: -[A1]-[B/A2]-, where [A1] represents a polymer block composed of a structural unit derived from a methacrylic acid ester (A1), [B/A2] represents a copolymer block composed of a structural unit derived from an acrylic acid ester (B) and a structural unit derived from a methacrylic acid ester (A2), and the copolymer block [B/A2] has a gradient copolymer block section in which a copolymerization ratio of the methacrylic acid ester (A2) continuously increases from a section connected to the polymer block [A1]. The block copolymer has a total content of the structural units derived from the methacrylic acid ester (A1) and the methacrylic acid ester (A2) of 5% to 60% by mass, a weight-average molecular weight (Mw) of 30,000 to 300,000, and a molecular weight distribution (Mw/Mn) of 1.0 to 1.5.

Abstract: The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drugs lopinavir and ritonavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof.

Abstract: The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug efavirenz. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof.

Abstract: A method is provided for reducing the frequency of mis-directed output of hydroalcoholic gel from a dispenser. The hydroalcoholic gel includes at least 30 wt. % of a C1-4 alcohol, a polyacrylate thickener, and a plug-preventing additive that may be a C6-10 alkane diol. A method of reducing the formation of coagulated gel deposits, and dispensable hydroalcoholic gel compositions are also provided.

Abstract: The present invention relates to novel conjugates of active principles grafted to a polymer, to the nanoparticles comprising them, to their preparation and to their polymeric intermediates.

Abstract: The present invention provides a method of treating a skin ailment including administering to a subject in need thereof, a therapeutically effective amount of a composition including (i) a primary diamine; (ii) a secondary aromatic diamine; (iii) a polyisocyanate; and (iv) optionally, a polyol. The present invention also provides a method of forming a skin bandage.

Abstract: Novel inverse latices based on fatty alcohol ethers of formula R1—O—R2 (I) in which R1 and R2 represent, independently from one another, a linear or branched alkyl radical comprising from 5 to 18 carbon atoms; and cosmetic, dermocosmetic, dermopharmaceutical or pharmaceutical compositions comprising them.

Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.

Abstract: The present invention provides a water soluble, non-peptidic polymer comprising two or more alkylene oxide-based oligomers linked together by hydrolytically degradable linkages such as carbonates. Typically, the oligomer portion of the polymer is an amphiphilic triblock copolymer having a central propylene oxide block or butylene oxide block positioned between two ethylene oxide blocks. The polymer can be hydrolytically degraded into oligomers under physiological conditions. In aqueous media, the polymer preferably forms thermally reversible, hydrolytically degradable hydrogels that can be used, for example, for drug delivery and related biomedical applications.

Abstract: The present invention generally relates to anti-microbial formulations and methods of their use and production. The formulations of the present invention are effective as broad spectrum anti-bacterial agents with efficacy against both Gram-negative and Gram-positive bacteria, as anti-viral agents with efficacy against both enveloped and non-enveloped viruses, and as anti-fungal agents with efficacy against both vegetative and spore forms of microorganisms and against biofilms. The present invention includes anti-microbial compositions that have at least one surfactant, at least one acid, at least one peroxide (preferably hydrogen peroxide), peracetic acid, and water. The anti-microbial Formulations of the present invention may additionally contain an organic salt. The organic salt may be a salt of the same acid that is used in the Formulation or a salt of a different acid. Methods for production and use of the inventive compositions are disclosed.

Abstract: A biodegradable polymeric hydrogel composition including a component A and component B forming a ?-aminoester linkage such that the linkage results in gelation, wherein component A is water soluble polymer containing acrylate functionality and component B is a water soluble amine functionality useful for medical applications such as such as drug delivery, tissue engineering, and biomaterials and method of preparation thereof.

Abstract: A biodegradable drug delivery compositions comprising a triblock copolymer containing a polyester and a polyethylene glycol and a diblock copolymer containing a polyester and an end-capped polyethylene glycol, as well as a pharmaceutically active principle is disclosed.

Abstract: The present invention relates to dendrimer compositions configured for treating inflammatory disorders and autoimmune disorders, and related methods of synthesis. Specifically, the present invention relates to methods for treating rheumatoid arthritis with PAMAM dendrimers having functional ligands configured for treating rheumatoid arthritis (e.g., therapeutic agents, pro-drugs, targeting agents, trigger agents, imaging agents) (e.g., methotrexate).

Abstract: The present invention relates to an O/W type cosmetic composition with improved formulation stability, and more particularly, to an O/W type cosmetic composition comprising a branched polymer having a lipophilic alkyl side chain and an anionic surfactant, as active ingredients for improving formulation stability.

Abstract: Stabilization compositions for HIP emulsions are disclosed which include a combination of a Gemini surfactant, a sugar-derived compound and a hydrophobically modified polymer. HIP emulsions are disclosed which include the stabilizing composition. Amino-acid based Gemini surfactants may be employed in the stabilizing compositions.

Abstract: Described herein is a polyether polyamide block copolymer as well compositions and products containing the polyether polyamide block copolymer. Methods of making and using the copolymer, the compositions, and products are also described herein.

Abstract: Amphiphilic copolymer, containing at least a hydrophilic chain segment (A) and a hydrophobic chain segment (B), wherein the hydrophilic chain segment (A) contains peptides and wherein the hydrophobic chain segment (B) contains acetal groups or orthoester groups. The hydrophilic chain segment (A) preferably contains glutamine/glutamic acid units or asparagines/aspartic acid units, making a biodegradable copolymer which can form a thermogel.

Abstract: A perfuming composition capable of prolonging the release of a perfuming component into the surrounding environment when applied on a surface. This composition utilizes hydrophobic block copolymers in the presence of high amounts of ethanol. The invention also relates to consumer articles containing such compositions. It finally provides methods for the perfuming of a surface and a method for increasing the long-lastingness of a perfuming component using these compositions.

Abstract: The present disclosure relates, according to some embodiments, to methods of formulating a personal care product (e.g. sunscreen) composition that is stable when exposed to high and/or low temperatures for extended periods and that applies clear to wet skin and remains clear. A method may comprise, for example, combining a discontinuous oil phase with an emulsifying compound and one or more UV filters to form an oil phase mixture; heating and mixing the oil phase mixture; dispersing one or more non-emulsifying grade carbomer polymers in a continuous water phase to form a water phase mixture; combining and mixing the oil phase mixture and the water phase mixture to form a pre-emulsion; adding a neutralizing base to form a personal care product emulsion; adding water (e.g., to replace water lost during processing); and mixing the emulsion to form a homogenous composition. The present disclosure relates, in some embodiments, to compositions (e.g., stable compositions) for topical application to human skin (e.g.

Abstract: Provided are a polycaprolactone-polyphosphate block copolymer, a liquid composite formed by the block copolymer, a nucleic acid preparation, preparation methods for the copolymer and the liquid composite, and the use of the copolymer and the liquid composite in a nucleic acid medicine delivery system. The block copolymer prepared using the present invention has good biocompatibility, low cytotoxicity, and good biodegradability. The micelles provided in the present invention self-assemble into nano-particles in an aqueous solution, and have good stability, biocompatibility, and biodegradability, and low cytotoxicity. The preparation method is simple, has high repeatability, as a vector can protect small nucleic acids such as siRNA from biodegradation, can combine with the scale effect of nano-particles, and can be used for treating different diseases. Additionally, bonding targeting groups enable specificity recognition of different cancer cells.

Abstract: The present invention is directed to wetting agent compositions and methods for making and using the wetting agent compositions. The compositions of the invention include a sheeting agent, a defoaming agent, and an association disruption agent. The wetting agent compositions of the present invention result in a faster draining/drying time on most substrates compared to conventional wetting agents. The wetting agent compositions of the present invention are especially suitable for use on plastic substrates.