Aftertreated Solid Synthetic Organic Polymer (e.g., Grafting, Blocking, Etc.) Patents (Class 514/772.1)
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Patent number: 10849843Abstract: A cosmetic ink composition comprises a particulate material, a (meth)acrylic acid homopolymer or salt thereof, and a rheology modifier. The particulate material can have a Particle Size Distribution D50 of about 100 nm to about 2,000 nm. The (meth)acrylic acid homopolymer or salt thereof can have a weight average molecular weight of less than about 20,000 daltons. The rheology modifier can be selected from the group consisting of alkali swellable emulsion polymers, hydrophobically modified alkali swellable emulsion polymers, and combinations thereof. The cosmetic ink composition can have a first dynamic viscosity of greater than about 1,100 cP at a shear rate of 0.1 sec?1 measured at 25° C. and a second dynamic viscosity of less than about 100 cP at a shear rate of 1,000 sec?1 measured at 25° C.Type: GrantFiled: January 31, 2019Date of Patent: December 1, 2020Assignee: The Procter & Gamble CompanyInventors: Janette Villalobos Lingoes, Thomas Elliot Rabe, Matthew Joseph Linser, Ajay Suthar
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Patent number: 10835482Abstract: A composition (d) includes (per 100% of its weight): a) 90 wt.-% to 99.0 wt.-% water including, in dissolved form, 0.002 mol/L to 0.1 mol/L of at least one salt of ammonium cation or of a monovalent or multivalent metal cation with an organic or inorganic anion; b) 0.5 wt.-% to 5 wt.-% of at least one crosslinked anionic polyelectrolyte; and c) 0.5 wt.-% to 5 wt.-% of at least one compound having formula (II), where the weight ratio of the crosslinked anionic polyelectrolyte to the compound of formula (II) is greater than or equal to 0.2 and less than or equal to 2.0, and the molar ratio of the compound of formula (II) to the salt is greater than or equal to 0.05 and less than or equal to 1. Also disclosed is the composition in cosmetics and to a method for lightening the thickened salt-rich composition.Type: GrantFiled: July 18, 2017Date of Patent: November 17, 2020Assignee: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPICInventors: Benoit Verdu, Cindy Sourdon, Alicia Roso
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Patent number: 10813857Abstract: A cosmetic ink composition comprises a particulate material, a polymeric dispersant having a weight average molecular weight of less than about 20,000 daltons, and a polymeric rheology modifier. The particulate material can have a Particle Size Distribution D50 of about 100 nm to about 2,000 nm. The cosmetic ink composition can undergo controlled syneresis, forming a weak colloidal gel phase and a particle-lean, low viscosity phase, which can be printed without interventions such as agitation, mixing, or re-circulation to homogenize the composition.Type: GrantFiled: January 31, 2019Date of Patent: October 27, 2020Assignee: The Procter & Gamble CompanyInventors: Janette Villalobos Lingoes, Thomas Elliot Rabe, Jeremy Chang, Ajay Suthar
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Patent number: 10794000Abstract: A method for manufacturing printed textiles includes the steps of: a) inkjet printing an image onto a textile substrate with one or more inkjet printing liquids containing thermally reactive composite resin particles in an aqueous medium; and b) fixing the inkjet printed image by applying directly and/or indirectly a heat treatment to the image; wherein the thermally reactive composite resin particles contain at least one thermal cross-linker and at least one polymeric resin containing functional groups suitable for reacting with the thermal cross-linker.Type: GrantFiled: July 28, 2016Date of Patent: October 6, 2020Assignee: AGFA NVInventors: Lionel Petton, Johan Loccufier, Ellen Bertels
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Patent number: 10786477Abstract: Novel active compositions having antimicrobial and anti-inflammatory activity are described, the activity provided by an active component prepared in a suspension, the active component being at least a single chain fatty acid having a carbon length of 12, or between 12 and no more than 18. The fatty acid may be esterified and/or ethylated or methylated. As an antimicrobial the active component has activity against one or more microorganisms including Staphylococcus spp., Streptococcus spp., Mycobacterium spp., Clostridium spp., and Candida spp., with an MIC as low as 0.0018 ?g/ml. As an anti-inflammatory, it is at least as or is more effective than cyclosporine in preventing T-cell proliferation in response to a trigger, such as stimulation by the one or more microorganisms. The active component is more active when combined with a phospholipid (e.g., lecithin, phosphatidylcholine) and caused to form liposomal nanoparticles. It is also more active when caused to form coated liposomal nanoparticles.Type: GrantFiled: October 16, 2015Date of Patent: September 29, 2020Assignee: Natureza, Inc.Inventors: Lynn S. James-Meyer, Gerald C. Coles
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Patent number: 10479873Abstract: Provided is a method of producing a polymer-impregnated base resin which is excellent in providing low adsorption of proteins and blood cells such as platelets. The method of producing a polymer-impregnated base resin includes impregnating a base resin with a polymer solution that includes a solvent able to swell the base resin.Type: GrantFiled: April 16, 2018Date of Patent: November 19, 2019Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., KYUSHU UNIVERSITY, NATIONAL UNVIERSITY CORPORATIONInventors: Yasuhisa Minagawa, Keiji Tanaka, Hisao Matsuno, Toyoaki Hirata
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Patent number: 10328095Abstract: A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting a plurality of oxidized cellulose microspheres into a lumen of a blood vessel to at least partially block the lumen.Type: GrantFiled: March 14, 2014Date of Patent: June 25, 2019Assignee: Covidien LPInventors: Phillip Blaskovich, Rachit Ohri, Olga Cherniavsky
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Patent number: 10328014Abstract: The invention relates to a cosmetic process for caring for the skin, more particularly facial skin, in particular wrinkled skin, comprising the topical application to the skin of a cosmetic composition comprising a grafted polysaccharide polymer (I) and exposure of the treated skin to light radiation, polymer (I) being of formula: PS—(CO—NH-L-X)a(COOH)b in which PS denotes the basic backbone of the polysaccharide bearing the carboxylic acid groups; L is a divalent hydrocarbon-based group containing from 1 to 20 carbon atoms; X denotes a photoactive group of azide or diazirine type; a denotes the content of COOH groups substituted with the group —NH-L-X; b denotes the content of unsubstituted free COOH groups; a being between 0.01 and 0.8; b being between 0.2 and 0.99; a+b=1 The invention also relates to the polymers (I) bearing a photoactive group X of diazirine type and to a composition comprising such a polymer in a physiologically acceptable medium.Type: GrantFiled: December 10, 2015Date of Patent: June 25, 2019Assignee: L'OREALInventor: Andrew Greaves
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Patent number: 10285399Abstract: A dispensable hydroalcoholic gel composition is provided. The dispensable hydroalcoholic gel includes a C1-4 alcohol, a polyacrylate thickener, and a glyceryl ester.Type: GrantFiled: November 7, 2016Date of Patent: May 14, 2019Assignee: GOJO Industries, Inc.Inventors: David R. Macinga, Sarah L. Edmonds, Kristin E. Hartzell, Kelly A. Dobos, Carol A. Quezada
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Patent number: 10278388Abstract: A dispensable gel composition is provided. The dispensable gel composition includes a C1-4 alcohol, a polyacrylate thickener, and a diol plug-preventing additive. The dispensable gel exhibits less misdirection during dispensing from a dispensing device than gel compositions that are otherwise identical, but for the presence of the plug-preventing additive.Type: GrantFiled: February 12, 2018Date of Patent: May 7, 2019Assignee: GOJO Industries, Inc.Inventors: David R. Macinga, Sarah L. Edmonds, Kristin E. Hartzell, Kelly A. Dobos, Carol A. Quezada
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Patent number: 10271548Abstract: A dispensable gel composition is provided. The dispensable gel composition includes a C1-4 alcohol, a polyacrylate thickener, and a plug-preventing additive. The dispensable gel exhibits less misdirection during dispensing from a dispensing device than gel compositions that are otherwise identical, but for the presence of the plug-preventing additive.Type: GrantFiled: February 12, 2018Date of Patent: April 30, 2019Assignee: GOJO Industries, Inc.Inventors: David R. Macinga, Sarah L. Edmonds, Kristin E. Hartzell, Kelly A. Dobos, Carol A. Quezada
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Patent number: 10258716Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological pH solution; wherein the biocompatible polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.Type: GrantFiled: April 19, 2017Date of Patent: April 16, 2019Assignee: MicroVention, Inc.Inventors: Gregory M. Cruise, Michael J. Constant, Edward Michael Keeley, Rob Greene, Clayton Harris
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Patent number: 10130093Abstract: A dispensable gel composition is provided. The dispensable gel composition includes a C1-4 alcohol, a polyacrylate thickener, a diol plug-preventing additive, and one or more neutralizers. The one or more neutralizers are selected from sodium hydroxide, ammonium hydroxide, potassium hydroxide, arginine, tetrahydroxypropyl ethylenediamine, triethanolamine, tromethamine, and triisopropanolamine.Type: GrantFiled: May 22, 2018Date of Patent: November 20, 2018Assignee: GOJO Industries, Inc.Inventors: David R. Macinga, Sarah L. Edmonds, Kristin E. Hartzell, Kelly A. Dobos, Carol A. Quezada
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Patent number: 10124077Abstract: Described herein are compositions and methods for cancer cell biomarkers, such as pancreatic ductal adenocarcinoma (PDAC) cell biomarkers, and binding molecules for diagnosis and treatment of cancer, e.g., PDAC. Methods of identifying “accessible” proteomes are disclosed for identifying cancer biomarkers, such as plectin-1, a PDAC biomarker. Additionally, imaging compositions are provided comprising magnetofluorescent nanoparticles conjugated to peptide ligands for identifying PDACs.Type: GrantFiled: June 8, 2016Date of Patent: November 13, 2018Assignee: The General Hospital CorporationInventors: Kimberly Kelly, Ralph Weissleder, Nabeel Bardeesy
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Patent number: 10118980Abstract: Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.Type: GrantFiled: May 24, 2017Date of Patent: November 6, 2018Assignee: Terumo CorporationInventors: Steve Plotkin, Gregory M. Cruise, Edward Michael Keeley, Renee Yu, Clayton Harris
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Patent number: 10064870Abstract: The present disclosure relates generally to sol-gel polymer composites that comprise chitosan, a hydrophilic polymer, a gelation agent, and optional additional ingredients in a suitable medium. Advantageously, the sol-gel polymer composite can form a durable seal or strong solid in response to one or more physiological stimulus. The disclosure further relates to medical and veterinary uses of the composite, particularly, methods and delivery systems for reducing or preventing the incidence of a mammary disorder in a dairy animal. More particularly, the disclosure includes methods and sol-gel polymer composite compositions for creating a physical barrier on the teat surface or in the teat canal or cistern of a non-human animal for prophylactic treatment of mammary disorders such as mastitis wherein the sol-gel polymer creates a seal in response to one or more physiological stimulus.Type: GrantFiled: November 2, 2016Date of Patent: September 4, 2018Assignee: Zoetis Services LLCInventors: Sumitra Rajagopalan, Wilms Baille, Piotr Kujawa, Christopher A. Zook, Rebecca R. Quesnell, Dennis L. Huczek, Stephen L. Secreast, Laibin Luo, Tammy A. Sanders
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Patent number: 10010585Abstract: Methods to reduce the proliferation of vestibular schwannoma (VS) cells and/or provide neuroprotection to reduce the risk of sensorineural hearing loss (SNHL), vestibular dysfunction and facial nerve paralysis in subjects with VS. The methods can include one or more of decreasing TNF-? activity or expression; decreasing NF-?B expression or activity; decreasing COX-2 expression or activity; administering FGF2; decreasing HGF expression or activity; or decreasing c-Met expression or activity.Type: GrantFiled: June 16, 2015Date of Patent: July 3, 2018Assignee: Massachusetts Eye and Ear InfirmaryInventors: Konstantina Stankovic, Sonam Dilwali
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Patent number: 10004227Abstract: A dispensable hydroalcoholic gel composition is provided. The dispensable hydroalcoholic gel includes a C1-4 alcohol, a polyacrylate thickener, one or more neutralizers, and an additive. The dispensable hydroalcoholic gel exhibits less misdirection during dispensing from a dispensing device than gel compositions that are otherwise identical, but for the presence of the additive.Type: GrantFiled: June 30, 2016Date of Patent: June 26, 2018Assignee: GOJO Industries, Inc.Inventors: David R. Macinga, Sarah L. Edmonds, Kristin E. Hartzell, Kelly A. Dobos, Carol A. Quezada
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Patent number: 9683148Abstract: An adhesive containing a block copolymer having at least one structure represented by formula: -[A1]-[B/A2]-, where [A1] represents a polymer block composed of a structural unit derived from a methacrylic acid ester (A1), [B/A2] represents a copolymer block composed of a structural unit derived from an acrylic acid ester (B) and a structural unit derived from a methacrylic acid ester (A2), and the copolymer block [B/A2] has a gradient copolymer block section in which a copolymerization ratio of the methacrylic acid ester (A2) continuously increases from a section connected to the polymer block [A1]. The block copolymer has a total content of the structural units derived from the methacrylic acid ester (A1) and the methacrylic acid ester (A2) of 5% to 60% by mass, a weight-average molecular weight (Mw) of 30,000 to 300,000, and a molecular weight distribution (Mw/Mn) of 1.0 to 1.5.Type: GrantFiled: May 9, 2014Date of Patent: June 20, 2017Assignee: KURARAY CO., LTD.Inventors: Kanayo Nakada, Yoshihiro Morishita
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Patent number: 9532979Abstract: The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drugs lopinavir and ritonavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof.Type: GrantFiled: September 7, 2012Date of Patent: January 3, 2017Assignee: The University of LiverpoolInventors: Marco Norman Giardiello, Thomas Oliver McDonald, Andrew Owen, Steven Paul Rannard, Philip John Martin, Darren Lee Smith
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Patent number: 9498438Abstract: The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug efavirenz. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof.Type: GrantFiled: September 7, 2012Date of Patent: November 22, 2016Assignee: The University of LiverpoolInventors: Marco Norman Giardiello, Thomas Oliver McDonald, Andrew Owen, Steven Paul Rannard, Philip John Martin, Darren Lee Smith
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Patent number: 9402393Abstract: A method is provided for reducing the frequency of mis-directed output of hydroalcoholic gel from a dispenser. The hydroalcoholic gel includes at least 30 wt. % of a C1-4 alcohol, a polyacrylate thickener, and a plug-preventing additive that may be a C6-10 alkane diol. A method of reducing the formation of coagulated gel deposits, and dispensable hydroalcoholic gel compositions are also provided.Type: GrantFiled: June 14, 2010Date of Patent: August 2, 2016Assignee: GOJO INDUSTRIES, INC.Inventors: David R. Macinga, Sarah L. Edmonds, Kristin E. Hartzell, Kelly A. Dobos, Carol A. Quezada
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Patent number: 9278137Abstract: The present invention relates to novel conjugates of active principles grafted to a polymer, to the nanoparticles comprising them, to their preparation and to their polymeric intermediates.Type: GrantFiled: November 18, 2011Date of Patent: March 8, 2016Assignees: SANOFI, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE PAUL SABATIER TOULOUSE IIIInventors: Abderrhamane Amgoune, Didier Bazile, Fethi Bensaid, Didier Bourissou, Eric Didier, Stephanie Greco, Harivardhan Reddy Lakkireddy, Serge Sable, Michel Veillard
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Patent number: 9259436Abstract: The present invention provides a method of treating a skin ailment including administering to a subject in need thereof, a therapeutically effective amount of a composition including (i) a primary diamine; (ii) a secondary aromatic diamine; (iii) a polyisocyanate; and (iv) optionally, a polyol. The present invention also provides a method of forming a skin bandage.Type: GrantFiled: March 28, 2014Date of Patent: February 16, 2016Assignee: Chesson Laboratory Associates, Inc.Inventors: Jerry S. Chesson, Timothy J. Romack, Lance L. Swick, David R. Terry
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Patent number: 9180085Abstract: Novel inverse latices based on fatty alcohol ethers of formula R1—O—R2 (I) in which R1 and R2 represent, independently from one another, a linear or branched alkyl radical comprising from 5 to 18 carbon atoms; and cosmetic, dermocosmetic, dermopharmaceutical or pharmaceutical compositions comprising them.Type: GrantFiled: June 22, 2009Date of Patent: November 10, 2015Assignee: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPICInventors: Olivier Braun, Paul Mallo, Hervé Rolland
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Patent number: 9078930Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.Type: GrantFiled: March 15, 2013Date of Patent: July 14, 2015Assignee: Intezyne Technologies, Inc.Inventors: Kevin Sill, Tomas Vojkovsky, Adam Carie
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Patent number: 9040060Abstract: The present invention provides a water soluble, non-peptidic polymer comprising two or more alkylene oxide-based oligomers linked together by hydrolytically degradable linkages such as carbonates. Typically, the oligomer portion of the polymer is an amphiphilic triblock copolymer having a central propylene oxide block or butylene oxide block positioned between two ethylene oxide blocks. The polymer can be hydrolytically degraded into oligomers under physiological conditions. In aqueous media, the polymer preferably forms thermally reversible, hydrolytically degradable hydrogels that can be used, for example, for drug delivery and related biomedical applications.Type: GrantFiled: May 16, 2011Date of Patent: May 26, 2015Assignee: Nektar TherapeuticsInventors: Michael D. Bentley, J. Milton Harris, Xuan Zhao, William Dudley Battle, III, Xiaoming Shen
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Patent number: 9034930Abstract: A biodegradable polymeric hydrogel composition including a component A and component B forming a ?-aminoester linkage such that the linkage results in gelation, wherein component A is water soluble polymer containing acrylate functionality and component B is a water soluble amine functionality useful for medical applications such as such as drug delivery, tissue engineering, and biomaterials and method of preparation thereof.Type: GrantFiled: September 10, 2012Date of Patent: May 19, 2015Assignee: Council of Scientific & Industrial ResearchInventors: Hemant Ravindran Nair, Mohan Gopalkrishna Kulkarni
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Patent number: 9034390Abstract: The present invention generally relates to anti-microbial formulations and methods of their use and production. The formulations of the present invention are effective as broad spectrum anti-bacterial agents with efficacy against both Gram-negative and Gram-positive bacteria, as anti-viral agents with efficacy against both enveloped and non-enveloped viruses, and as anti-fungal agents with efficacy against both vegetative and spore forms of microorganisms and against biofilms. The present invention includes anti-microbial compositions that have at least one surfactant, at least one acid, at least one peroxide (preferably hydrogen peroxide), peracetic acid, and water. The anti-microbial Formulations of the present invention may additionally contain an organic salt. The organic salt may be a salt of the same acid that is used in the Formulation or a salt of a different acid. Methods for production and use of the inventive compositions are disclosed.Type: GrantFiled: May 10, 2007Date of Patent: May 19, 2015Assignee: BIONEUTRAL LABORATORIES CORPORATIONInventor: Andrew Kielbania, Jr.
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Patent number: 9023897Abstract: A biodegradable drug delivery compositions comprising a triblock copolymer containing a polyester and a polyethylene glycol and a diblock copolymer containing a polyester and an end-capped polyethylene glycol, as well as a pharmaceutically active principle is disclosed.Type: GrantFiled: December 29, 2011Date of Patent: May 5, 2015Assignee: MedinCellInventor: Georges Gaudriault
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Patent number: 9017644Abstract: The present invention relates to dendrimer compositions configured for treating inflammatory disorders and autoimmune disorders, and related methods of synthesis. Specifically, the present invention relates to methods for treating rheumatoid arthritis with PAMAM dendrimers having functional ligands configured for treating rheumatoid arthritis (e.g., therapeutic agents, pro-drugs, targeting agents, trigger agents, imaging agents) (e.g., methotrexate).Type: GrantFiled: November 9, 2009Date of Patent: April 28, 2015Assignee: The Regents of the University of MichiganInventors: James R. Baker, Jr., Larry A. Sternson, David Repp, Deborah Ladenheim
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Publication number: 20150105476Abstract: The present invention relates to an O/W type cosmetic composition with improved formulation stability, and more particularly, to an O/W type cosmetic composition comprising a branched polymer having a lipophilic alkyl side chain and an anionic surfactant, as active ingredients for improving formulation stability.Type: ApplicationFiled: December 18, 2014Publication date: April 16, 2015Inventors: Jung Yeob Jeong, Young So Kim, Sung Il Park, Youn Joon Kim, Sang Hun Han
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Publication number: 20150098912Abstract: Described herein is a polyether polyamide block copolymer as well compositions and products containing the polyether polyamide block copolymer. Methods of making and using the copolymer, the compositions, and products are also described herein.Type: ApplicationFiled: May 18, 2012Publication date: April 9, 2015Applicant: CRODA INTERNATIONAL PLCInventors: Geng Lin, Nancy W. Harman
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Publication number: 20150099638Abstract: Stabilization compositions for HIP emulsions are disclosed which include a combination of a Gemini surfactant, a sugar-derived compound and a hydrophobically modified polymer. HIP emulsions are disclosed which include the stabilizing composition. Amino-acid based Gemini surfactants may be employed in the stabilizing compositions.Type: ApplicationFiled: October 6, 2014Publication date: April 9, 2015Inventors: Steve Cochran, Masashi Yamamoto, Daphne Benderly, Christine Lynn Lummer, Marie Yednak-Carpenter
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Publication number: 20150099808Abstract: Amphiphilic copolymer, containing at least a hydrophilic chain segment (A) and a hydrophobic chain segment (B), wherein the hydrophilic chain segment (A) contains peptides and wherein the hydrophobic chain segment (B) contains acetal groups or orthoester groups. The hydrophilic chain segment (A) preferably contains glutamine/glutamic acid units or asparagines/aspartic acid units, making a biodegradable copolymer which can form a thermogel.Type: ApplicationFiled: December 10, 2014Publication date: April 9, 2015Inventors: Jorge HELLER, Sebastien Jerome PIERRE, Mike Gerardus Wilhelmus DE LEEUW, Jeroen PIEPER
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Patent number: 9000052Abstract: A perfuming composition capable of prolonging the release of a perfuming component into the surrounding environment when applied on a surface. This composition utilizes hydrophobic block copolymers in the presence of high amounts of ethanol. The invention also relates to consumer articles containing such compositions. It finally provides methods for the perfuming of a surface and a method for increasing the long-lastingness of a perfuming component using these compositions.Type: GrantFiled: October 19, 2009Date of Patent: April 7, 2015Assignee: Firmenich SAInventors: Damien Berthier, Sébastien Lecommandoux, Isabelle Schmidt, Christophe Schatz
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Publication number: 20150093444Abstract: Provided are a polycaprolactone-polyphosphate block copolymer, a liquid composite formed by the block copolymer, a nucleic acid preparation, preparation methods for the copolymer and the liquid composite, and the use of the copolymer and the liquid composite in a nucleic acid medicine delivery system. The block copolymer prepared using the present invention has good biocompatibility, low cytotoxicity, and good biodegradability. The micelles provided in the present invention self-assemble into nano-particles in an aqueous solution, and have good stability, biocompatibility, and biodegradability, and low cytotoxicity. The preparation method is simple, has high repeatability, as a vector can protect small nucleic acids such as siRNA from biodegradation, can combine with the scale effect of nano-particles, and can be used for treating different diseases. Additionally, bonding targeting groups enable specificity recognition of different cancer cells.Type: ApplicationFiled: October 23, 2012Publication date: April 2, 2015Applicant: SUZHOU RIBO LIFE SCIENCE CO., LTD.Inventors: Hongyan Zhang, Jun Wang
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Publication number: 20150093343Abstract: The present disclosure relates, according to some embodiments, to methods of formulating a personal care product (e.g. sunscreen) composition that is stable when exposed to high and/or low temperatures for extended periods and that applies clear to wet skin and remains clear. A method may comprise, for example, combining a discontinuous oil phase with an emulsifying compound and one or more UV filters to form an oil phase mixture; heating and mixing the oil phase mixture; dispersing one or more non-emulsifying grade carbomer polymers in a continuous water phase to form a water phase mixture; combining and mixing the oil phase mixture and the water phase mixture to form a pre-emulsion; adding a neutralizing base to form a personal care product emulsion; adding water (e.g., to replace water lost during processing); and mixing the emulsion to form a homogenous composition. The present disclosure relates, in some embodiments, to compositions (e.g., stable compositions) for topical application to human skin (e.g.Type: ApplicationFiled: September 30, 2014Publication date: April 2, 2015Inventors: Craig A. Bonda, Qing Jean Zhang
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Publication number: 20150082750Abstract: The present invention is directed to wetting agent compositions and methods for making and using the wetting agent compositions. The compositions of the invention include a sheeting agent, a defoaming agent, and an association disruption agent. The wetting agent compositions of the present invention result in a faster draining/drying time on most substrates compared to conventional wetting agents. The wetting agent compositions of the present invention are especially suitable for use on plastic substrates.Type: ApplicationFiled: November 25, 2014Publication date: March 26, 2015Inventors: Victor Fuk-Pong Man, Janel Marie Kieffer, Michael Charles Denoma, Yvonne Marie Killeen, Joshua P. Magnuson
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Patent number: 8986728Abstract: The present invention provides an implantable device having a biosoluble coating or a biosoluble body structure comprising a polyelectrolyte and a counterion and the methods of making and using the same.Type: GrantFiled: July 9, 2012Date of Patent: March 24, 2015Assignee: Abbott Cardiovascular Systems Inc.Inventors: Syed F. A. Hossainy, Mikael O. Trollsas, Lothar W. Kleiner
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Patent number: 8980238Abstract: Because of the formation of disulfide bridges with mucus glycoproteins, the mucoadhesive properties of polymeric compounds can be significantly improved by the covalent attachment of thiol substructures to them. By the transformation of free thiol groups on such polymers in disulfides with mercaptonicotinamides or mercaptopyridoxins these thiol groups become comparatively more reactive resulting in significantly improved mucoadhesive properties. Furthermore, polymers exhibiting disulfide partial structures with mercaptonicotinamides or mercaptopyridoxins do not need to be protected against oxidation. In addition, they show comparatively higher permeation enhancing properties.Type: GrantFiled: September 29, 2010Date of Patent: March 17, 2015Assignees: Thiomatrix Forschungs—Und Beratungs GmbH, Croma Pharma GmbHInventor: Johannes Leierer
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Patent number: 8980957Abstract: The subject invention relates to a method of preparing a biocompatible polymer comprising epsilon-linked L-lysine having free alpha-amino and carboxy functions. The invention further encompasses the resulting biocompatible polymer and articles made from the polymer, in particular contact and intraocular lenses.Type: GrantFiled: January 11, 2011Date of Patent: March 17, 2015Assignee: CIS Pharma AGInventors: Rolf Schäfer, Hans Hitz
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Publication number: 20150073020Abstract: Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, which composition has a surface tension of 40 dynes/cm or less and has continuing spreadability, and which composition is effective in treating a disorder of the nail or nail bed.Type: ApplicationFiled: September 19, 2014Publication date: March 12, 2015Inventors: Gareth Winckle, Gregory T. Fieldson
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Publication number: 20150071864Abstract: A reversely thermo-reversible hydrogel composition comprising a water soluble block copolymer comprising at least two blocks of polyethylene oxide and at least one block of polypropylene oxide, and at least one associative gelling adjuvant having water solubility less than 0.5 g/100 ml, preferably less than 0.3 g/100 ml at 20° C., and being capable of forming water soluble inter-molecular complexes with the water soluble block copolymer in water. The hydrogel composition exhibits improved gelling efficiency, enhanced solubility and/or stability for water sparely soluble and insoluble pharmaceutical agents. The hydrogel compositions are useful in a variety of pharmaceutical and cosmetic products and applications, such as esophageal, otic, vaginal, rectal, ophthalmic, treatments of disorders and imperfections of the skin, and treating and/or preventing alopecia and restoring and/or promoting hair growth.Type: ApplicationFiled: September 22, 2014Publication date: March 12, 2015Applicant: Broda Technologies Co., Ltd.Inventors: Shao Xiang LU, Jeffrey LU, Letian LIU
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Publication number: 20150071860Abstract: A micelle comprising a diblock polymer with a cyclic polyethylene glycol block and a hydrophobic block is provided. The micelle may be used in conjunction with one or a combination of therapeutic agents, targeting agents, and imaging agents. The micelle may be incorporated in a pharmaceutical composition.Type: ApplicationFiled: September 9, 2014Publication date: March 12, 2015Inventors: Coleen Pugh, Gladys R. Montenegro-Galindo
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Publication number: 20150073059Abstract: Organopolysiloxane gels produced by crosslinking an unsaturated organopolysiloxane resin with a crosslinking agent in the presence of a diluent have excellent sensory properties such as properties desirable in a variety of cosmetics products.Type: ApplicationFiled: April 11, 2013Publication date: March 12, 2015Inventors: Sebastian Knoer, Aroop Kumar Roy
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Publication number: 20150065586Abstract: The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.Type: ApplicationFiled: November 14, 2014Publication date: March 5, 2015Inventor: Rao S. Bezwada
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Publication number: 20150057367Abstract: Micro-sized particles having a polymeric structure of cells are provided. Also provided is a method of producing micro-sized particles having a polymeric structure comprising: (1) forming a homogenous solution by heating a mixture of a high molecular weight polymer and a low molecular weight material, wherein said low molecular weight material makes up at least about 50% by weight of the homogenous solution, (2) forming a dispersed solution by dispersing the homogenous solution formed in step (1) into an inert material, (3) cooling the dispersed solution to cause the high molecular weight polymer to phase separate from the low molecular weight material, (4) forming solid particles comprised of said low molecular weight material trapped inside a structure of cells of said high molecular weight polymer, and (5) removing the solid particles from the dispersed solution.Type: ApplicationFiled: September 1, 2014Publication date: February 26, 2015Inventors: Xiaorong Wang, Mindaugas Rackaitis, Naruhiko Mashita, Victor Foltz
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Patent number: 8962008Abstract: The present invention relates to a novel polymeric material with enhanced hydrophilicity for medical use comprising a biocompatible polyester material selected from the group consisting of poly(hydroxyalkanoate)s, poly(lactic acid)s, poly(glycolic acid)s, poly(caprolactone)s and copolymers and blends thereof, wherein the biocompatible polyester material is crosslinked with a functionalized poly(alkylene oxide) having at least two functional groups independently selected from the group consisting of azido-formate and alkanoyl azide. The novel polymeric material with enhanced hydrophilicity is useful as a biocompatible material in a variety of medical applications, including medical implants, bioresorbable implants, tissue engineering, and controlled release.Type: GrantFiled: June 20, 2012Date of Patent: February 24, 2015Assignees: Technische Universitat Graz, Medical University of Graz MUG, AT&S Austria Technologie & Systemtechnik Aktiengesellschaft, Herabus Medical GmbHInventors: Frank Wiesbrock, Clemens Ebner, Franz Stelzer, Annelie-Martina Weinberg, Klaus-Dieter Kühn
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Publication number: 20150045451Abstract: The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.Type: ApplicationFiled: August 7, 2014Publication date: February 12, 2015Inventors: Durgadas Bolikal, Joachim B. Kohn, Lioubov Kabalnova