Polyvinyl Alcohol Patents (Class 514/772.2)
  • Patent number: 10517839
    Abstract: This application discloses methods for treating or preventing an ophthalmic retinal vascular permeability, angiogenic or fibroproliferative disease, disorder or condition that involve administering to a patient in need thereof a composition that can inhibit mast cell migration into the vitreous or the retina, mast cell proliferation in the vitreous or the retina, or mast cell secretion into the vitreous or the retina.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: December 31, 2019
    Assignee: Cornell University
    Inventors: Randi B. Silver, Nathan O'Connor
  • Publication number: 20150139906
    Abstract: Surface-modified polymeric nanoparticles (NPs), compositions for making them, and their use in drug delivery are disclosed.
    Type: Application
    Filed: October 14, 2014
    Publication date: May 21, 2015
    Inventors: Vinod Labhasetwar, Jaspreet Vasir
  • Patent number: 9034843
    Abstract: The present invention provides an ophthalmic composition which stabilizes the tear film during wearing contact lens, prevents eye dryness, imparts a favorable sensation in using, is highly convenient with no risk of misuse and shows a high efficiency in the course from manufacturing to sales. More specifically, the present invention provides a wetting solution—eye drops for contact lenses comprising (A) one or more member(s) selected from the group consisting of a cellulose-based polymer, a vinyl-based polymer, polyethylene glycol and dextran; and (B) one or more member(s) selected from the group consisting of chondroitin sulfate, alginic acid and salts thereof; and (C) a nonionic surfactant.
    Type: Grant
    Filed: September 11, 2008
    Date of Patent: May 19, 2015
    Assignee: Rohto Pharmaceutical Co., Ltd.
    Inventors: Yasuko Matsumura, Kazuhiro Fukushima
  • Patent number: 8992993
    Abstract: Biodegradable cross-linked particles, as well as related compositions and methods, are disclosed.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: March 31, 2015
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Robert E. Richard
  • Publication number: 20150056152
    Abstract: An emulsion is obtained from emulsion polymerization of a mixture of (a) 1-50 wt % of a triorganosiloxysilicic acid and (b) 50-99 wt % of an ethylenically unsaturated monomer in the presence of (c) an emulsion stabilizer which is an anionic surfactant, nonionic surfactant or polyvinyl alcohol. The emulsion is used to formulate a cosmetic composition capable of forming, on drying, a film which has water resistance, oil resistance and toughness and is thus effective for preventing makeup deterioration. The cosmetic composition containing the emulsion is useful as eyeliner, mascara, eyebrow color, liquid foundation or milky lotion.
    Type: Application
    Filed: August 25, 2014
    Publication date: February 26, 2015
    Inventors: Yukihiro MASUDA, Kentaro WATANABE, Akira YAMAMOTO
  • Publication number: 20150038594
    Abstract: Described herein are orodispersible films comprising a film forming hydrophobic polymer, a disintegrant, a plasticizer and a stabilizer.
    Type: Application
    Filed: July 31, 2014
    Publication date: February 5, 2015
    Applicant: Bluepharma
    Inventors: Ana Filipa Silva Borges, Branca Margarida Almeida Silva, Jorge Fernando Jordao Coelho, Claudia Sousa Silva, Sergio Paulo Simoes
  • Patent number: 8846089
    Abstract: A method is provided for producing a sugar-coated preparation including a solid composition containing a pharmacologically active ingredient and a sugar coating layer. The method comprises a step of forming the sugar coating layer with a sugar coating composition containing one or more sugar-alcohols selected from the group consisting of mannitol and erythritol and a polyvinyl alcohol-based resin. The sugar-coated preparation includes a solid composition containing a pharmacologically active ingredient and a sugar coating layer, wherein the sugar coating layer is made of a sugar coating composition containing one or more sugar-alcohols selected from the group consisting of mannitol and erythritol and a polyvinyl alcohol-based resin.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: September 30, 2014
    Assignee: Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Yukoh Sakata, Masaharu Higuchi
  • Publication number: 20140255516
    Abstract: The compositions and methods of this invention relate to peelable film-forming compositions that may be applied to and removed from the skin containing polyvinyl alcohols and adhesion-enhancing polymers.
    Type: Application
    Filed: April 28, 2014
    Publication date: September 11, 2014
    Applicant: JOHNSON & JOHNSON CONSUMER COMPANIES, INC.
    Inventors: Prashant Bahadur, Jeffrey M. Wu, Kamesh R. Yerramilli
  • Publication number: 20140242024
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Application
    Filed: May 8, 2014
    Publication date: August 28, 2014
    Applicant: Covidien LP
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla, Timothy Sargeant, Joshua Stopek
  • Patent number: 8771739
    Abstract: The present invention provides a pharmaceutical composition of a practically insoluble drug, wherein the composition may be administered with food or without food. The composition may be in the form of a solid dispersion of the practically insoluble drug and a polymer having acidic functional groups, and the composition may in vitro form a suspension.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: July 8, 2014
    Assignee: Mayne Pharma International Pty Ltd
    Inventors: David Hayes, Angelo M. Morella
  • Patent number: 8728449
    Abstract: Water-soluble articles such as films, which can be made resistant to contact with small amounts of water, and methods of making the same are disclosed. The water-soluble article is formed from a water-soluble film-forming composition, such as polyvinyl alcohol, and includes a salt that is distributed more closely to at least one of the surfaces than throughout its thickness.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: May 20, 2014
    Assignee: Monosol LLC
    Inventors: Andrew P. Verrall, Steven G. Friedrich
  • Publication number: 20140127311
    Abstract: The present invention provides biocompatible nano-polymer particles which are composed of a biocompatible polymer, a stabilizer and an active agent for the treatment of pulmonary hypertension or erectile dysfunction and which can be used to produce a pharmaceutical preparation for the treatment of pulmonary hypertension or erectile dysfunction. Biocompatible nano-polymer particles of this invention have a diameter ranging from 10 nm to 10 ?m auf, a stabilizing layer thickness between 0 and 50 nm, contain between 0 and 50% of an active agent for the treatment of pulmonary hypertension or erectile dysfunction, are nebulizable and continuously release the active agent over a period of up to 48 hours. Biocompatible nano-polymer particles of this invention can be synthesized for example using the emulsion technique known to the expert with subsequent solvent evaporation or via spray drying.
    Type: Application
    Filed: May 23, 2012
    Publication date: May 8, 2014
    Applicant: JUSTUS-LIEBIG-UNIVERSITAET GIESSEN
    Inventors: Moritz Beck-Broichsitter, Thomas Schmehl, Tobias Gessler, Thomas Kissel
  • Publication number: 20140120062
    Abstract: Disclosed are composites comprising water-soluble polymeric fibers dispersed in a biodegradable polymer matrix, as well as methods of making and using such composites.
    Type: Application
    Filed: November 16, 2011
    Publication date: May 1, 2014
    Inventor: Carlos A. Cruz
  • Patent number: 8703196
    Abstract: A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: April 22, 2014
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, William J. Curatolo, Dwayne T. Friesen, Rodney J. Ketner, Julian B. Lo, James A. S. Nightingale, Ravi M. Shanker, James B. West
  • Patent number: 8697756
    Abstract: The invention relates to compositions containing at least 90% by weight of dimer diol for use in a method for the surgical or therapeutic treatment of the human or animal body, and in particular to the use thereof as a body fluid replacement substance.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: April 15, 2014
    Assignee: ACTO e.V.
    Inventor: Norbert Schrage
  • Publication number: 20140072514
    Abstract: The present disclosure is directed to a class of fluorinated copolymers, such as PTFE copolymers, that can be dissolved in low toxicity solvents, such as Class III Solvents, and that enable the creation of stable water-in-solvent emulsions comprising the fluorinated copolymers dissolved in a low toxicity solvents and a hydrophilic agent (e.g., a therapeutic agent) dissolved in an aqueous solvent, such as water or saline.
    Type: Application
    Filed: September 12, 2013
    Publication date: March 13, 2014
    Applicant: W. L. Gore & Associates, Inc.
    Inventors: Robert L. Cleek, Edward H. Cully, Paul D. Drumheller, Theresa A. Holland
  • Patent number: 8658204
    Abstract: An object of the present invention is to provide a liposome which is excellent in intrapulmonary delivery controllability of drugs or genes and is suited for pulmonary administration. By modifying the surface of a liposome using a terminal hydrophobized polyvinyl alcohol and/or chitosan, retention of drugs or genes encapsulated in the liposome on the surface of lung tissue and transfer of drugs or genes into lung tissue can be properly modulated, and thus in vivo behavior can be controlled.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: February 25, 2014
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Hirofumi Takeuchi, Koji Nakano, Hidekazu Toyobuku
  • Publication number: 20130338238
    Abstract: Provided is a base material for dry direct tableting, the material being excellent in a binding property and disintegrability. More specifically, provided is a method of preparing a composite granule comprising at least a step of granulating a second sugar or sugar alcohol while adding thereto an aqueous dispersion comprising at least low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of 5 to 16% by weight, polyvinyl alcohol, a first sugar or sugar alcohol, and water.
    Type: Application
    Filed: June 4, 2013
    Publication date: December 19, 2013
    Inventors: Naosuke Maruyama, Yasuyuki Hirama
  • Publication number: 20130324548
    Abstract: The invention relates to chemoembolization composition for anti-angiogenic agent delivery. The invention further relates to a method of preparing chemoembolization composition and to the use of chemoembolization composition in the method for treating solid tumour cancers.
    Type: Application
    Filed: November 29, 2011
    Publication date: December 5, 2013
    Applicant: CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
    Inventors: Alban Denys, Pierre Bize, Olivier Jordan, Eric Doelker, Nathalie Boulens
  • Patent number: 8580853
    Abstract: A soluble aspirin composition, comprising: (i) granules including aspirin, heat-treated bicarbonate salt, pharmaceutically-acceptable resin and surfactant, in mixture with: (ii) crystalline particles of pharmaceutically-acceptable acid; and (iii) crystalline particles of heat-treated bicarbonate salt; wherein the soluble aspirin composition when introduced to water undergoes reaction of the crystalline particles of pharmaceutically-acceptable acid with the heat-treated bicarbonate salt and the aspirin to effect effervescing action and disintegration of the granules with conversion of the aspirin to an acetylsalicylate compound of the bicarbonate salt cation so that the composition rapidly dissolves in the water without occurrence of undissolved residue. The composition is solublizable within 30 seconds in cool to cold water to provide an effervescent analgesic solution that can be readily orally administered to an individual in need of analgesia.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: November 12, 2013
    Inventor: Howard Phykitt
  • Publication number: 20130296761
    Abstract: There is provided a gel sheet that has high biocompatibility and safety, can contain both a hydrophilic medicinal agent and a hydrophobic medicinal agent, and provides an excellent feel in use during the application onto human skin or others. A gel sheet including: a lipid peptide gelator including a low molecular weight lipid peptide having a molecular weight of 1,000 or less or a pharmaceutically usable salt of the lipid peptide; and a polymeric compound, wherein the polymeric compound is included in an amount of more than 1% (w/w) and less than 50% (w/w) with respect to the total mass of the gel sheet.
    Type: Application
    Filed: November 11, 2011
    Publication date: November 7, 2013
    Applicants: KYUSHU UNIVERSITY, NISSAN CHEMICAL INDUSTRIES, LTD.
    Inventors: Masahiro Goto, Takayuki Imoto, Tsubasa Kashino, Takehisa Iwama, Nobuhide Miyachi
  • Publication number: 20130289135
    Abstract: The present invention relates to compositions comprising a polymeric substrate comprising at least one volume excluding polymer. In one embodiment, the present invention provides polymeric articles that are capable of acting as osmotic drivers. The articles are capable of maintaining a desired water balance by moving water in or out of a substrate to maintain cation concentration equilibrium between the substrate and its environment.
    Type: Application
    Filed: June 27, 2013
    Publication date: October 31, 2013
    Inventors: Brian J. Tighe, Muriel Nasso, Beverley Benning, Frank F. Molock, JR.
  • Patent number: 8524368
    Abstract: The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic charge densities that decrease by removal of removable functional groups from the polymers. The present invention also provides interpolyelectrolyte complexes containing the polymers complexed to a polyanion. Methods for using the interpolyelectrolyte complexes to deliver anionic compounds are also provided.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: September 3, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David M. Lynn, Adam D. Miller
  • Publication number: 20130209529
    Abstract: Provided herein are phenylboronate containing co-polymers (PCC), compositions containing PCC and polyvinyl alcohol (PVA), such compositions further including proteins, methods of making these compositions by water in oil polymerization, and methods of using the protein containing compositions for releasing proteins. Such phenylboronate containing co-polymers are of Formula I: where m, n, p, x, R1-R5, L, X1 and X2 are defined in the application.
    Type: Application
    Filed: August 8, 2011
    Publication date: August 15, 2013
    Applicant: Indian Institute of Technology Kanpur
    Inventors: Ashok Kumar, Rachamalla Maheedhar Reddy
  • Publication number: 20130195769
    Abstract: The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.
    Type: Application
    Filed: March 11, 2013
    Publication date: August 1, 2013
    Applicant: FOAMIX LTD.
    Inventor: Foamix Ltd.
  • Publication number: 20130177517
    Abstract: Aqueous emulsions of organopolysiloxanes functionalized with a limited amount of aminoalkyl-functional end groups and silicone resins are storage stable, yet capable of adequate crosslinking upon application to substances to be hydrophobicized.
    Type: Application
    Filed: September 12, 2011
    Publication date: July 11, 2013
    Applicant: WACKER CHEMIE AG
    Inventors: Markus Merget, Richard Becker, Franz Wimmer
  • Publication number: 20130171248
    Abstract: A composition for oral delivery of a poorly absorbed drug is disclosed. The composition includes the drug, an enhancer for increasing absorption of the drug through the intestinal mucosa, a promoter, which further increases the absorption of the drug in the presence of the enhancer, and optionally a protector for protecting the drug from physical or chemical decomposition or inactivation in the gastrointestinal tract. Illustrative enhancers include sucrose fatty acid esters, and illustrative promoters include aminosugars and amino acid derivatives, such as poly(amino acids). Illustrative protectors include methylcellulose, poly(vinyl alcohol), and poly(vinyl pyrrolidone).
    Type: Application
    Filed: September 14, 2012
    Publication date: July 4, 2013
    Applicant: PROCARRIER, INC.
    Inventors: Seung-Ho Choi, Seong-Wan Cho
  • Publication number: 20130165487
    Abstract: The present invention generally relates to aqueous seed treatment formulations comprising from about 0.2 to about 15% of at least one pesticidal agent, from about 0.1 to about 0.45% of at least one graft copolymer, at least one polyvinyl alcohol (PVA), and from about 5 to about 30% of at least one plasticizer. The present invention also relates to aqueous seed treatment formulations wherein the pesticidal agents are clothianidin, metconazole, and metalaxyl.
    Type: Application
    Filed: February 22, 2013
    Publication date: June 27, 2013
    Applicant: Valent U.S.A., Corporation
    Inventor: Valent U.S.A., Corporation
  • Publication number: 20130150459
    Abstract: A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.
    Type: Application
    Filed: January 4, 2013
    Publication date: June 13, 2013
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventor: Advanced Cardiovascular Systems, Inc.
  • Publication number: 20130142763
    Abstract: Crosslinked cellulosic polymers, crosslinked cellulosic polymer hydro-gels, and methods for their synthesis and use are described. The crosslinked cellulosic polymers include one or more cellulosic polymers and a one or more crosslinkers that crosslinks the one or more cellulosic polymers together. The crosslinking can be facilitated with a crosslinking agent capable of linking with a monomer the cellulosic polymer and crosslinking the cellulosic polymer intermoleculerly and/or intramolecularly. Crosslinked cellulosic polymers are well adapted for use in cell and tissue growth in vivo and in vitro. The crosslinked cellulose polymers may also be used as wound care devices.
    Type: Application
    Filed: October 27, 2010
    Publication date: June 6, 2013
    Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLC
    Inventors: William B. Carlson, Gregory D. Phelan, Philip A. Sullivan
  • Publication number: 20130136784
    Abstract: A method utilizing a dissolvable device for the internal delivery of medication and more particularly to the use of fibers or non-woven fabrics made of a safe polymer material incorporating a medication that is released by dissolution of the fibers or non-woven fabrics over time, and more particularly a treatment method for controlling or regulating the pH in the vagina by stabilizing and adjusting the pH in the vagina by minimizing the impact of the vaginal flora.
    Type: Application
    Filed: January 23, 2013
    Publication date: May 30, 2013
    Inventor: Robert J. Staab
  • Publication number: 20130129825
    Abstract: The invention relates to the use of an oral dosage form based on microgranules and/or microtablets to reduce the abusive use of at least one active principle contained therein. The aim of the invention is to prevent the diversion of an oral dosage form based on microgranules and/or microtablets containing at least one active principle capable of causing a dependency, a gelling agent, and a gelling activator. The gelling agent and the activator are only brought into contact with each other in the event of diversion by crushing. Said judiciously selected pair of excipients confers a viscosity to the formulation, such that said formulation cannot be administered by injection or does not release the active principle rapidly by forming a gel when it comes into contact with the mucous membrane if nasally administered.
    Type: Application
    Filed: June 7, 2011
    Publication date: May 23, 2013
    Applicant: Ethypharm
    Inventor: Vincent Billoet
  • Publication number: 20130123371
    Abstract: Anisotropic hydrogels including poly(vinyl alcohol) and which have physical cross-links so as to form materials which exhibit anisotropic mechanical properties characteristic of soft biological tissues wherein the anisotropic hydrogel may be used for tissue reconstruction and/or replacement including vessels, arteries, valve components, cartilage, ligaments, skin, and other medical uses such as stents, medical phantoms, contact lenses, bandages, and the like.
    Type: Application
    Filed: December 14, 2012
    Publication date: May 16, 2013
    Applicant: THE UNIVERSITY OF WESTERN ONTARIO
    Inventor: THE UNIVERSITY OF WESTERN ONTARIO
  • Publication number: 20130108648
    Abstract: The present technology provides a nanoparticulate in-situ gelling vitreous substitute, which is a liquid at room temperature to aid easy administration, such as e.g. through a small needle incision, and forms a gel within the eye, which is hydrophilic in nature, similar to the natural vitreous. The vitreous substitute formulation may include a water-soluble natural or synthetic polymer and a gelling-agent which are blended together in the presence of a cross linker, to form a gel having the properties of the vitreous humor. The process of cross linking and gelation may occur in-situ. This can be achieved by dispensing to the eye, different components of the vitreous substitute in liquid state, along with the cross linking agent.
    Type: Application
    Filed: December 21, 2012
    Publication date: May 2, 2013
    Applicant: Indian Institute of Technology Bombay
    Inventor: Indian Institute of Technology Bombay
  • Publication number: 20130098550
    Abstract: A method for adhering a medical device to biological tissue includes adhering an adhesive composition having a plurality of reactive members of a specific binding pair to tissue which has a plurality of complementary reactive members of the specific binding pair via click chemistry.
    Type: Application
    Filed: March 24, 2011
    Publication date: April 25, 2013
    Applicant: COVIDIEN LP
    Inventors: Tim Sargeant, Robert Ahmad Hadba, Joshua Stopek
  • Publication number: 20130096207
    Abstract: Provided is a water dispersion type sex pheromone sustained release preparation which makes it possible to suppress excess release at the initial stage of spraying and release a sex pheromone substance at a constant amount for a predetermined period, and which can be sprayed by using a common sprayer. Specifically provided is a water dispersion type sex pheromone sustained release preparation, comprising an insect sex pheromone substance which is enclosed in a ring of a cyclodextrin, an inclusion cyclodextrin which encloses the insect sex pheromone substance, a non-inclusion cyclodextrin which does not enclose the insect sex pheromone substance, a water-soluble polymer, and water.
    Type: Application
    Filed: October 2, 2012
    Publication date: April 18, 2013
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventor: Shin-Etsu Chemical Co., Ltd.
  • Patent number: 8414905
    Abstract: Film coating compositions based on a co-processed mixture of a polyvinyl alcohol-polyether graft polymer and polyvinyl alcohol (component A), a N-vinylpyrrolidone-vinyl acetate copolymer (component B) and pigments (component C).
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: April 9, 2013
    Assignee: BASF SE
    Inventors: Thorsten Cech, Verena Geiselhart, Thorsten Agnese
  • Patent number: 8414927
    Abstract: Biodegradable cross-linked particles, as well as related compositions and methods, are disclosed.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: April 9, 2013
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Robert E. Richard
  • Publication number: 20130065765
    Abstract: The present disclosure relates to degradable superabsorbent materials based on acetals of glyoxylic acid and derivatives thereof with polyvinyl alcohol, and methods of making the polymers. The polymers are used to make superabsorbent particles, coatings, sheets, and fibers. Formulations and articles including the superabsorbent polymers, particles, coatings, sheets, and fibers are also disclosed.
    Type: Application
    Filed: July 5, 2011
    Publication date: March 14, 2013
    Inventors: Sergey Selifonov, Marc Scholten, Ning Zhou
  • Publication number: 20130058880
    Abstract: Compositions, kits and methods of preparing a biocompatible film for cosmetic or medical uses are disclosed. The compositions or kits contain polyvinyl acetal (PVA), siloxane and a solvent. The siloxane can have a hydrophilic group. Once the solvent content is reduced, for instance, by evaporation, the mixture of PVA and siloxane is solidified, forming a film. The compositions and kits, optionally, further include one or more of an antimicrobial agent, a pigment, an anti-inflammatory agent, an anesthetic agent or a hemostatic agent. Such a film can be used, for example, in the form of an antimicrobial sealant, a liquid bandage, body paints, scar camouflage, water-proof sun block, makeup sealer, or antimicrobial wipe or spray.
    Type: Application
    Filed: May 9, 2011
    Publication date: March 7, 2013
    Inventor: Shaosheng Dong
  • Patent number: 8362091
    Abstract: A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: January 29, 2013
    Assignee: Foamix Ltd.
    Inventors: Dov Tamarkin, Doron Friedman, Meir Eini, Alex Besonov
  • Publication number: 20130023507
    Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
    Type: Application
    Filed: September 28, 2012
    Publication date: January 24, 2013
    Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC.
    Inventor: ADVANCED CARDIOVASCULAR SYSTEM, INC.
  • Publication number: 20130023508
    Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
    Type: Application
    Filed: September 28, 2012
    Publication date: January 24, 2013
    Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC.
    Inventor: ADVANCED CARDIOVASCULAR SYSTEMS, IN
  • Publication number: 20130023509
    Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
    Type: Application
    Filed: September 28, 2012
    Publication date: January 24, 2013
    Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC.
    Inventor: ADAVANCED CARDIOVASCULAR SYSTEMS,IN
  • Publication number: 20130017235
    Abstract: With an object of providing an orally administered agent (in particular a film-shaped orally administered agent) with which the ease and safety of taking the agent are improved, to attain this object, in an orally administered agent 1b having one drug-containing layer 11 and two water-swellable gel-forming layers 12, the water-swellable gel-forming layers 12 are provided, either directly or via intermediate layers, on the both faces of the drug-containing layer 11.
    Type: Application
    Filed: August 16, 2012
    Publication date: January 17, 2013
    Applicant: LINTEC CORPORATION
    Inventor: Eiji NOGAMI
  • Publication number: 20130018110
    Abstract: The invention provides a method for preparing a hydrogel from a hydrophilic polymer having one or more functional groups which are capable of co-reacting in a condensation reaction which method comprises the steps of: (i) preparing a solution of the polymer; (ii) heating the solution to a temperature sufficient for the condensation reaction to take place for a period of time sufficient for the hydrogel to cross-link wherein where the hydrophilic polymer comprises a first and a second hydrophilic polymer, step (i) comprises a step of mixing the hydrophilic polymers to prepare a homogeneous intimate mixture of the polymers; and wherein the heating step (ii) is carried out at a pressure greater than atmospheric pressure. The method of the invention is advantageous because it is relatively low cost, it is a safer procedure with less health & safety concerns, it is carried out in a liquid state and is not limited by film thickness.
    Type: Application
    Filed: January 20, 2011
    Publication date: January 17, 2013
    Applicant: The University of Reading
    Inventors: Vitaliy Khutoryanskiy, Olga Khutoryanskaya, Joseph Peter Cook, Glenn William Goodall
  • Publication number: 20130005643
    Abstract: The present invention relates to a method for preparing nano-particles, and more particularly, to a method for preparing nano-particles containing active materials in a simple and highly efficient manner through a grinding process.
    Type: Application
    Filed: March 22, 2011
    Publication date: January 3, 2013
    Applicant: Bio-Synetics Inc.
    Inventors: Kab Sig Kim, Joo Won Park
  • Publication number: 20130005831
    Abstract: The present disclosure provides rapidly dissolving oral capsules and films comprising pullulan, a plasticizer, and a dissolution enhancing agent.
    Type: Application
    Filed: December 22, 2011
    Publication date: January 3, 2013
    Applicant: UNIVERSITY OF KANSAS
    Inventors: Roger A. Rajewski, Lian G. Rajewski, John L. Haslam
  • Publication number: 20120309851
    Abstract: The present invention relates to methods for removing residual surface material from porous polymerized particle surfaces. The particles thus produced have an increase in surface porosity and uniformity in a variety of applications. Desirably, substantially the entire surface communicates with the interior of the particles. Also provided are the particles produced by such methods, further modifications of such particles, and methods for using the particles in a variety of applications. All described methods, compositions, and articles of manufacture are within the scope of the invention.
    Type: Application
    Filed: May 4, 2010
    Publication date: December 6, 2012
    Inventors: Nai-Hong Li, Yuchiong Hsuanyu, James R. Benson, Marc Freed
  • Publication number: 20120308656
    Abstract: A method is provided for producing a sugar-coated preparation including a solid composition containing a pharmacologically active ingredient and a sugar coating layer. The method comprises a step of forming the sugar coating layer with a sugar coating composition containing one or more sugar-alcohols selected from the group consisting of mannitol and erythritol and a polyvinyl alcohol-based resin. The sugar-coated preparation includes a solid composition containing a pharmacologically active ingredient and a sugar coating layer, wherein the sugar coating layer is made of a sugar coating composition containing one or more sugar-alcohols selected from the group consisting of mannitol and erythritol and a polyvinyl alcohol-based resin.
    Type: Application
    Filed: May 30, 2012
    Publication date: December 6, 2012
    Applicant: Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Yukoh Sakata, Masaharu Higuchi