Heterocyclic Monomer Patents (Class 514/772.7)
  • Patent number: 10266698
    Abstract: The present disclosure provides colorant compounds and methods of isolation of the colorant compounds derived from a reaction of genipin and an amine. The colorant compositions comprise purified compounds (e.g., a purified polymer or a purified dimer) obtained from multiple fractioning by chromatography of the reaction resulting material. The purified polymer or dimer can be used as a colorant by itself or in combination with another colorant for imparting color to a food, a drug, a cosmetic, a medical device, and textile products.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: April 23, 2019
    Assignee: ECOFLORA S.A.S.
    Inventors: Esteban Vargas Cano, Luis Fernando Echeverri Lopez, Juan Fernando Gil Romero, Edwin Andrés Correa Garcés, Sandra Patricia Zapata Porras
  • Patent number: 9745419
    Abstract: Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for a variety of applications, including, but not limited to, drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: August 29, 2017
    Assignee: Vanderbilt University
    Inventors: Eva M. Harth, Benjamin R. Spears
  • Publication number: 20150132372
    Abstract: The present disclosure relates to aqueous compositions for use in the manufacture of capsule shells and capsules with a functional polymer dispersion. The present disclosure relates to aqueous compositions for use in the manufacture of capsule shells endowed with controlled release properties. The present disclosure also relates to aqueous compositions for use in the manufacture of capsule shells and capsules endowed with moisture barrier properties. The present disclosure also relates to methods of manufacturing the capsule shell and capsules, and to capsule shells and capsules obtained therewith.
    Type: Application
    Filed: March 14, 2013
    Publication date: May 14, 2015
    Inventors: Hassan Benameur, Keith Hutchison
  • Patent number: 8992949
    Abstract: Compositions comprising a polymer-based macroscopically homogeneous polymer alloy comprising a plurality of microcrystalline components dispersed within an amorphous component, which is biocompatible, bioerodable, substantially non-toxic, and excretable, or metabolized when introduced into a mammalian body. In preferred embodiments, malleable molded devices such as implants, films, drug delivery systems and the like, are comprised of the compositions. Methods of making such compositions by controlled cooling of the molten alloy are also described.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: March 31, 2015
    Assignee: Unicare Biomedical, Inc.
    Inventor: Shih-Liang Yang
  • Publication number: 20150086607
    Abstract: A synthetic construct suitable for implantation into a biological organism that includes at least one polymer scaffold; wherein the at least one polymer scaffold includes at least one layer of polymer fibers that have been deposited by electrospinning; wherein the orientation of the fibers in the at least one polymer scaffold relative to one another is generally parallel, random, or both; and wherein the at least one polymer scaffold has been adapted to function as at least one of a substantially two-dimensional implantable structure and a substantially three-dimensional implantable tubular structure.
    Type: Application
    Filed: September 25, 2014
    Publication date: March 26, 2015
    Inventors: Jed K. JOHNSON, Ross KAYUHA
  • Publication number: 20150079005
    Abstract: Nanocarriers are synthesized with polymers that respond to lower pH and/or ROS by being degraded. The compositions may be utilized to selectively deliver payloads within patients by responding to lower pH and/or ROS at localities within the patient. The present invention also features methods of synthesizing nanocarriers that are degraded by lower pH and/or ROS.
    Type: Application
    Filed: May 7, 2014
    Publication date: March 19, 2015
    Applicant: The Regents of the University of California
    Inventors: Adah Almutairi, Jagadis Sankaranarayanan, Enas Mahmoud, Eric Schopf
  • Publication number: 20150073060
    Abstract: The present invention provides compositions and methods relating to polylactides which may be used for drug delivery (e.g., parenteral delivery), wherein an organic solvent is not required.
    Type: Application
    Filed: April 22, 2014
    Publication date: March 12, 2015
    Applicant: UNIVERSITY OF GENEVA
    Inventors: Michael MOLLER, Thomas TRIMAILLE, Robert GURNY
  • Patent number: 8974813
    Abstract: A water-swellable linear polymer is made by reacting together a polyethylene oxide of number average molecular weight less than 4,000, an aliphatic diol, and a difunctional diisocyanate. Controlled release composition comprises the polymer together with an active agent. The polymer is able to take up pharmaceutically active agents of molecular weight 200 to 20,000.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: March 10, 2015
    Assignee: Ferring B.V.
    Inventors: Jukka Tuominen, Amaia Zurutuza, Mark Livingstone, Janet Anne Halliday
  • Publication number: 20150064106
    Abstract: Biodegradable polyphosphazene polymers containing pyrrolidone side groups, and the biomedical use of such polyphosphazene polymers are disclosed.
    Type: Application
    Filed: November 7, 2014
    Publication date: March 5, 2015
    Inventors: Alexander Andrianov, Bryan Roberts
  • Patent number: 8968783
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: March 3, 2015
    Assignee: Covidien LP
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla
  • Publication number: 20150045451
    Abstract: The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.
    Type: Application
    Filed: August 7, 2014
    Publication date: February 12, 2015
    Inventors: Durgadas Bolikal, Joachim B. Kohn, Lioubov Kabalnova
  • Patent number: 8952075
    Abstract: Bioactive liquid formulations are formed of combinations of absorbable, segmented aliphatic polyurethane compositions and liquid polyether for use as vehicles for the controlled release of at least one active agent for the conventional and unconventional treatment of different forms of cancer and the management of at least one type of bacterial, fungal, and viral infection.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: February 10, 2015
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Publication number: 20150018431
    Abstract: In one aspect, the present disclosure pertains to lubricous coating compositions that comprise (a) a higher molecular weight polyvinylpyrrolidone, (b) a lower molecular weight polyvinylpyrrolidone, and (c) a polyfunctional unsaturated crosslinking agent. In some embodiments, such lubricous coating compositions are present in crosslinked form on the surface of a medical article. In some embodiments, the lubricous coating compositions further comprise a solvent, in which case such compositions may be, for example, applied to a substrate in the form of a layer and subsequently crosslinked, thereby forming a lubricious coating on the substrate. In another aspect, the present disclosure is directed to methods for forming various medical articles.
    Type: Application
    Filed: July 14, 2014
    Publication date: January 15, 2015
    Inventors: Hongxia Zeng, Jan Seppala, Yen-Lane Chen, Raghav Goel
  • Publication number: 20150004206
    Abstract: The invention relates to a process for preparing PCL-comprising microparticles, to microparticles obtainable by said process, to gel hence obtained and to several uses of the gel such as for the preparation of a medicament for treating a skin abnormality or disfigurement, and/or for controlling bladder function and/or controlling gastric reflux and/or for treating erectile dysfunction and/or for treating vocal cords. The gel may also be used for cosmetic applications.
    Type: Application
    Filed: July 1, 2014
    Publication date: January 1, 2015
    Inventors: Henderikus Supèr, Paul Willem Mijnen, Pieter Gerard Zijlstra, Dirk Wybe Grijpma
  • Patent number: 8920793
    Abstract: The present invention relates to the preparation of poly(amino oxalate) (PAOX) using oxalyl chloride, 1,4-cyclohexanedimethanol, and piperazinediethanol, the preparation of biodegradable polymer particles using the PAOX, and the use of PAOX particles as a drug delivery vehicle. The PAOX according to the present invention is a polymer that has three characteristics of biodegradability, biocompatibility, and cationic properties at the same time with appropriate hydrophobicity and thus can be prepared as particles that allow rapid drug release. Moreover, the particles improve the delivery efficiency of a drug into cells and thus can be efficiently used as a drug delivery vehicle for the treatment of acute inflammatory diseases such as acute liver failure and acute lung injury.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: December 30, 2014
    Assignee: Industrial Cooperation Foundation Chonbuk National University
    Inventors: Dong Won Lee, Kyeong Yeol Seong, Han Sol Seo, Hyung Min Kim, Ye Rang Kim
  • Patent number: 8912236
    Abstract: The present invention relates to development of efficacious pharmaceutical implant compositions comprising an active agent in a therapeutically effective amount and a polyethylene glycol having a molecular weight of at least 2000.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: December 16, 2014
    Assignee: Alcon Research, Ltd.
    Inventors: Bhagwati P. Kabra, Malay Ghosh, Adrian Sauceda
  • Publication number: 20140350127
    Abstract: The present disclosure provides colorant compounds and methods of isolation of the colorant compounds derived from a reaction of genipin and an amine. The colorant compositions comprise purified compounds (e.g., a purified polymer or a purified dimer) obtained from multiple fractioning by chromatography of the reaction resulting material. The purified polymer or dimer can be used as a colorant by itself or in combination with another colorant for imparting color to a food, a drug, a cosmetic, a medical device, and textile products.
    Type: Application
    Filed: May 22, 2014
    Publication date: November 27, 2014
    Applicant: ECOFLORA S.A.S.
    Inventors: Esteban Vargas CANO, Luis Fernando Echeverri Lopez, Juan Fernando Gil Romero, Edwin Andrés Correa Garcés, Sandra Patricia Zapata Porras
  • Publication number: 20140342003
    Abstract: Poly(amine-co-ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the nanoparticles are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition.
    Type: Application
    Filed: June 2, 2014
    Publication date: November 20, 2014
    Inventors: W. Mark Saltzman, Zhaozhong Jiang, Jiangbing Zhou
  • Patent number: 8852640
    Abstract: Embodiments include a vehicle for delivery of nitric oxide comprising: a collection of micelles having an internal micelle core that comprises a polymer with N-diazeniumdiolate comprising NO complexed with secondary amines of the polymer. Embodiments include a method of making a nitric oxide vehicle comprising dissolving a polymer that comprises secondary amines in an aqueous solution and combining the polymer with nitric oxide in the solution to form a N-diazeniumdiolate comprising the nitric oxide complexed with the secondary amines, with the formation of the N-diazeniumdiolate causing the polymer to be at least partially insoluble in the solution and to form a collection of micelles that have an internal core that comprises N-diazeniumdiolate.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: October 7, 2014
    Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Jeffrey A. Hubbell, Yun Suk Jo, André van der Vlies
  • Publication number: 20140294912
    Abstract: Implantable devices formed of or coated with a material that includes an amorphous poly(D,L-lactide) formed of a starting material such as meso-D,L-lactide are provided. The implantable device can be used for the treatment, mitigation, prevention, or inhibition of a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
    Type: Application
    Filed: June 17, 2014
    Publication date: October 2, 2014
    Inventors: Stephen D. Pacetti, Syed Faiyaz Ahmed Hossainy, David C. Gale
  • Publication number: 20140287014
    Abstract: This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.
    Type: Application
    Filed: January 20, 2014
    Publication date: September 25, 2014
    Inventors: Timothy A. Ringeisen, William Christopher Wattengel
  • Patent number: 8841351
    Abstract: The present invention relates to topical antibacterial compositions. The compositions comprise an antibacterial agent such as mupirocin, water, a polymer and a volatile solvent present in an amount of less than about 40%. The invention also relates to methods of treatment by administering the compositions to a patient in need thereof, and to the use of such compositions in the treatment of bacterial conditions.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: September 23, 2014
    Assignee: Stiefel Research Australia Pty Ltd.
    Inventor: Prashant Sawant
  • Publication number: 20140275287
    Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for use in tamponade hemostasis of bone or cartilage.
    Type: Application
    Filed: November 1, 2012
    Publication date: September 18, 2014
    Applicant: ABYRX, INC.
    Inventors: David Knaack, John Pacifico, Marci Wirtz, Richard L. Kronenthal, Frank Do, Aniq Darr
  • Patent number: 8834901
    Abstract: The present invention discloses polymeric materials that incorporate a modified quinone moiety, either to cross-link the polymer or as a monomeric unit of the polymer. These polymeric materials can be efficiently degraded through electrochemical reduction of the quinone leading to rapid hydrolysis of the pendant chemical groups and degradation of the polymer. Quinone-containing compositions and methods of producing electrochemically degradable polymers are disclosed. The methods and compositions of the present invention can be used in a wide variety of applications, including, but not limited to, drug delivery, tissue regeneration, biomedical implants, and electronic systems.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: September 16, 2014
    Assignee: Trustees of Tufts College
    Inventors: Marc d'Alarcao, Pericles Calias
  • Publication number: 20140256695
    Abstract: Systems and method are disclosed for forming a biocompatible cross-linked polymer having an interpenetrating polymer network (IPN) by cross-linking a heteropolysaccharide to form a single cross-linked material; and performing one or more additional cross-linkings on the single cross-linked material to form a multiple cross-linked material, wherein the multiple cross-linked material has one or more IPN regions resisting biodegradation in a human body than the single cross-linked material and one or more single cross-linked extensions radiating out from the IPN, wherein the combination of the IPN and the extension provide biodegradation resistance, soft touch feeling, and ease of insertion into the human body.
    Type: Application
    Filed: November 11, 2012
    Publication date: September 11, 2014
    Inventors: Phi Nguyen, Loc Phan, Bao Tran, Thuan Nguyen
  • Patent number: 8802738
    Abstract: The invention relates to polymers, such as aliphatic polyesters, with grafted zwitterions. More particularly, the invention relates to polyester-graft-phosphorylcholine polymers prepared by ring-opening polymerization and click chemistry, compositions and products comprising same, and related methods and uses, for example, in drug delivery.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: August 12, 2014
    Assignee: University of Massachusetts
    Inventor: Todd Emrick
  • Publication number: 20140179802
    Abstract: The present invention relates to a fiber comprising a biodegradable polymer which undergoes dimensional change upon injection in the human or animal body wherein the dimensional change is a reduction of the surface area to volume ratio of a factor 2 to 10. The fiber is sized for injection via a pharmaceutical syringe needle having a bore of at least 25 Gauge. The biodegradable polymer is an amorphous biodegradable polymer selected from the group of poly-hexamethylene carbonates or polyesteramides. The amorphous biodegradable polymer is a preferably a polyesteramide comprising alpha-amino acids, diols and dicarboxylic acids as building blocks. The invention further relates to the use of the fiber for the manufacturing of a medicament for the treatment of ophthalmic diseases. The invention also relates to a process for the manufacturing of the fiber comprising the following process steps; a. extruding a biodegradable polymer into a fiber fitting in a needle of at least 25 Gauge b.
    Type: Application
    Filed: May 2, 2012
    Publication date: June 26, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Astrid Franken, George Mihov, Jens Christoph Thies
  • Publication number: 20140178455
    Abstract: The present invention provides gradient porous scaffolds for bone regeneration and osteochondral defect repair, methods for making such gradient porous scaffolds, and methods for using the gradient porous scaffolds.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 26, 2014
    Inventors: Syam P. Nukavarapu, Cato T. Laurencin, Ami R. Amini, Deborah L. Dorcemus
  • Publication number: 20140161842
    Abstract: A bioresorbable porous film, including a blend mixture of polylactic acid and at least two kinds of polyethylene glycol, wherein the at least two kinds of polyethylene glycol include a first polyethylene glycol, which is in a solid form under ambient temperature and atmospheric pressure, and a second polyethylene glycol, which is in a liquid form under ambient temperature and atmospheric pressure is provided. The film has a porosity of 10%-90%.
    Type: Application
    Filed: April 25, 2013
    Publication date: June 12, 2014
    Applicant: Industrial Technology Research Institute
    Inventors: Li-Hsin LIN, Hsin-Hsin SHEN, Ying-Hsueh CHAO, Hsiu-Hua HUANG, Yu-Bing LIOU, Chih-Bing HUNG, Chin-Fu CHEN
  • Patent number: 8741877
    Abstract: The present invention provides compositions and methods relating to polylactides which may be used for drug delivery (e.g., parenteral delivery), wherein an organic solvent is not required.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: June 3, 2014
    Assignee: University of Geneva
    Inventors: Michael Moller, Thomas Trimaille, Robert Gurny
  • Publication number: 20140142131
    Abstract: Long acting injectable analgesic formulations and methods for providing long lasting pain relief in animals are disclosed.
    Type: Application
    Filed: November 8, 2013
    Publication date: May 22, 2014
    Applicant: A.P. PHARMA, INC.
    Inventors: Peter Hanson, Joseph K. Rosentel, John Barr
  • Publication number: 20140128345
    Abstract: Described are drug delivery systems incorporating electrospun fibers that comprise and deliver physicochemically diverse drug compounds. Such fibers provide significant advantages in drug agent release, such as adaptability for solid dosage delivery to mucosal tissues. This is in addition to allowing for controlled drug release. Systems and methods for large-scale electrospinning productivity are described, including novel microarchitectures allowing for variable pharmacokinetics in drug release.
    Type: Application
    Filed: November 6, 2013
    Publication date: May 8, 2014
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Kim A. Woodrow, Cameron Ball, Anna Blakney, Emily Krogstad, Huarong Nie
  • Patent number: 8716217
    Abstract: The present invention relates to novel biodegradable materials based on modified polyamino acids that are useful in particular in the vectorization of active principle(s) (APs). The invention is also directed to novel pharmaceutical, cosmetic, health-food or plant-protection compositions based on these polyamino acids. The aim of the invention is to provide a novel polymeric starting material which can be used for AP vectorization and which satisfy all the requirements: biocompatibility, biodegradability, ability to easily associate with or dissolve numerous active principles and to release these active principles in vivo. This goal is achieved by the present invention, which relates to novel polyglutamates modified by cationic groups, which, if they can be deprotonated, exhibit a pKa equal to or greater than 7, and by hydrophobic groups comprising from 8 to 30 carbon atoms.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: May 6, 2014
    Inventors: You-Ping Chan, Cecile Bonnet-Gonnet, Olivier Breyne
  • Patent number: 8715710
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: May 6, 2014
    Assignee: Heron Therapeutics, Inc.
    Inventors: Steven Y. Ng, Hui Rong Shen, Jorge Heller
  • Publication number: 20140120061
    Abstract: The present invention relates to compositions for oral administration. The invention preferably comprises at least one abuse-resistant drug delivery composition for delivering a drug having potential for dose dumping in alcohol, related methods of preparing these dosage forms, and methods of treating a patient in need thereof comprising administering the inventive compositions to the patient. Most preferably, the dosage form includes verapamil. These formulations have reduced potential for abuse. In another formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding.
    Type: Application
    Filed: July 8, 2013
    Publication date: May 1, 2014
    Inventors: Wolfgang Roth, Alexander Burst, Martina Zietsch
  • Publication number: 20140100292
    Abstract: The present invention relates inter alia to the use of moisture-conditioned disintegrants or expanding agents in tablet manufacture for the selective adjustment of the mechanical properties, the dissolution kinetics (dissolution) and/or the water loading of tablets.
    Type: Application
    Filed: October 8, 2013
    Publication date: April 10, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Eduard BALTHES, Johannes GESER, Peter SCHNEIDER
  • Publication number: 20140094399
    Abstract: Poly(?-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
    Type: Application
    Filed: September 17, 2013
    Publication date: April 3, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Robert S. Langer, David M. Lynn, David A. Putnam, Mansoor M. Amiji, Daniel Griffith Anderson
  • Publication number: 20140087060
    Abstract: A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (R; A), (ii) at least one reverse-flight section (D), and (iii) a discharging section (E), wherein the processing elements defining the reverse-flight section (R; D) comprise at least one reverse-flight element (14) which is based on a screw-type element having a conveying direction being opposite to the general conveying direction of the extruder.
    Type: Application
    Filed: December 2, 2013
    Publication date: March 27, 2014
    Applicant: AbbVie Deutschland GmbH & Co. KG
    Inventors: Thomas Kessler, Jörg Breitenbach, Christoph Schmidt, Matthias Degenhardt, Jörg Rosenberg, Harald Krull, Gunther Berndl
  • Publication number: 20140079780
    Abstract: The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.
    Type: Application
    Filed: November 19, 2013
    Publication date: March 20, 2014
    Applicant: GRUENENTHAL GMBH
    Inventors: Elisabeth ARKENAU MARIC, Johannes BARTHOLOMÄUS, Heinrich KUGELMANN
  • Publication number: 20140073705
    Abstract: Novel bioabsorbable polymeric blends are disclosed. The blends have a first component that is a polylactide polymers or a copolymer of lactide and glycolide and a second component that is poly(p-dioxanone) polymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel bioabsorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
    Type: Application
    Filed: November 20, 2013
    Publication date: March 13, 2014
    Applicant: Ethicon, Inc.
    Inventors: Brian M. Kelly, Dennis D. Jamiolkowski, Christopher DeFelice
  • Publication number: 20140066523
    Abstract: The invention provides moldable drug delivery carriers made up of a suspension of a solid phase and an organic liquid phase for the sustained release of a therapeutic agent. The invention also provides multiphase drug delivery systems made up of a granular hydrophobic solid phase, an organic liquid phase and a hydrogel, for sustained drug delivery at varying rates over the life of the composition.
    Type: Application
    Filed: May 1, 2012
    Publication date: March 6, 2014
    Applicant: ABYRX, Inc.
    Inventors: David Knaack, Ankur Gandhi, Jordan Katz, Marci Wirtz, Richard L. Kronenthal
  • Patent number: 8652506
    Abstract: A block or graft copolymer includes a first block, and a second block different from the first block, wherein the first block is a poly(lactide-glycolide) copolymer. The polymers may be formulated in compositions with drug components for use in coating medical devices such as stents. Different blocks of the block or graft copolymer degrade in the body at different rates. The drug release profile from the coating is a combination the individual release rates of the different blocks and so can be controlled by controlling the selection and relative amounts of the respective blocks.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: February 18, 2014
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Courtney Sikes, Mark Boden
  • Patent number: 8653030
    Abstract: A formulation containing a biologically active compound having a chemical structure with hydrogen bonding sites, a first biocompatible, hydrolytically degrading polycarbonate with hydrogen bonding sites and tyrosine-derived diphenol monomer units, and a second biocompatible hydrolytically degrading polymer that is less hydrophobic than the polycarbonate, wherein the second polymer degrades hydrolytically to form acidic degradation products that promote the release of the active compound. Methods for active compound delivery are also disclosed.
    Type: Grant
    Filed: January 7, 2008
    Date of Patent: February 18, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Joachim B. Kohn, Deborah M. Schachter
  • Publication number: 20140044787
    Abstract: The present application discloses a sustained release composition in pellet form, wherein the core of the pellet comprises: (a) a therapeutically effective amount of a medicament; (b) 0.5 to 50% by weight of a water-soluble polymer; and (c) 1 to 25% by weight of a water-insoluble polymer applied as an aqueous latex dispersion and subsequently the water is removed, wherein the sum of the percentages of the medicament, the water-insoluble polymer and the water-soluble polymer is equal to or less than 100%. It also discloses methods of making this composition.
    Type: Application
    Filed: October 18, 2013
    Publication date: February 13, 2014
    Applicant: NOSTRUM PHARMACEUTICALS, LLC
    Inventor: Nirmal MULYE
  • Patent number: 8648119
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agent compositions and formulations administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: February 11, 2014
    Assignees: Otonomy, Inc., The Regents of the University of California
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • Publication number: 20140038879
    Abstract: The invention discloses composition of oxidized conducting polymer and micelle assembly for site specific delivery of guest molecule. This delivery is achieved by by polyvalent interaction between micelle assemblies and delocalized charges of polymer to trigger the disassembly. The invention further discloses the process of preparation of composition of oxidized conducting polymer and micelle assembly for site specific delivery of guest molecule.
    Type: Application
    Filed: April 11, 2012
    Publication date: February 6, 2014
    Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventor: Kothandam Krishnamoorthy
  • Publication number: 20140030320
    Abstract: Biodegradable polyphosphazene polymers containing pyrrolidone side groups, and the biomedical use of such polyphosphazene polymers are disclosed.
    Type: Application
    Filed: October 1, 2013
    Publication date: January 30, 2014
    Inventors: Alexander Andrianov, Bryan Roberts
  • Patent number: 8632763
    Abstract: The use of copolymers obtained by free-radical polymerization of a mixture of i) 30 to 80% by weight of N-vinyllactam, ii) 10 to 50% by weight of vinyl acetate, and iii) 10 to 50% by weight of a polyether, with the proviso that the total of components i), ii) and iii) equals 100% by weight, as solubilizers for slightly water-soluble substances.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: January 21, 2014
    Assignee: BASF SE
    Inventors: Nathalie Bouillo, Marianna Pierobon, Ralf Widmaier, Rainer Dobrawa, Kathrin Meyer-Böhm, Ronald Frans-Maria Lange
  • Publication number: 20140005278
    Abstract: Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: June 17, 2013
    Publication date: January 2, 2014
    Applicant: Vanderbilt University
    Inventors: Eva M. Harth, Dain B. Beezer, GuangZhao Li, Benjamin R. Spears, David M. Stevens
  • Publication number: 20130331464
    Abstract: The present invention provides compositions and methods relating to polylactides which may be used for drug delivery (e.g., parenteral delivery), wherein an organic solvent is not required.
    Type: Application
    Filed: February 26, 2013
    Publication date: December 12, 2013
    Applicant: University of Geneva
    Inventor: University of Geneva