Solid Synthetic Organic Polymer Patents (Class 514/772.3)
  • Patent number: 10537125
    Abstract: Disclosed herein are chlorine dioxide releasing package label/inserts to be used inside a package or in an outer plastic bag containing several individual packages, the package label/insert containing (a) at least one layer of pectin and citric acid, (b) at least one layer of gelatin and sodium chlorite, (c) optionally at least one barrier layer containing gelatin (without sodium chlorite) between the at least one layer of pectin and citric acid and the at least one layer of gelatin and sodium chlorite, and (d) an adhesive joining said layers, wherein the package label/insert has alternating layers of the at least one layer of pectin and citric acid and the at least one layer of gelatin and sodium chlorite. Also disclosed are methods of killing microorganisms on an item using the package label/insert described herein.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: January 21, 2020
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Bassam A Annous, Carol Saade, Kit L. Yam
  • Patent number: 10525013
    Abstract: Cationic polymers are provided for delivering anionic active agents, preferably in the form or nanoparticles and other nanostructures. The polymer can be a polycation homopolymer or a copolymer containing a polycation block. The polycations and polycation containing polymers can contain dicarboxylic acid ester units and units of (?-amino acid)-?,?-alkylene diester units. The nanoparticles can contain high loadings of anionic active agents, with sustained release of the active agents. Methods of making the polycations and polycation containing polymers are provided. Methods of making the nanoparticles and formulating them for administration to an individual in need thereof are also provided.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: January 7, 2020
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Omid Farokhzad, Jun Wu, Lili Zhao
  • Patent number: 10322088
    Abstract: The present disclosure provides a sustained-release composition including a sodium hydrosulfide and a carrier. The carrier is provided for carrying the sodium hydrosulfide with an effective amount and includes a first component and a second component. The first component includes a paraffin wax, and the second component includes a fatty alcohol, a fatty acid or a phospholipid. The present disclosure also provides a method for fabricating the sustained-release composition. The method includes providing a first solution, providing the carrier, providing a second solution, performing an oil-in-water emulsification, and cooling the emulsion. In addition, the present disclosure provides a method for treating the chronic wounds. The method includes administering an effective amount of the aforementioned sustained-release composition to a subject suffered from the chronic wounds.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: June 18, 2019
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventors: Hsing-Wen Sung, Wei-Chih Lin, Shu-Jyuan Lin
  • Patent number: 10272015
    Abstract: Methods to enable a visual check on the mixing proper pharmaceutical compounding kits. The methods include providing a kit with a colored inactive to be added to the mixture. When the mixture is uniform or resembles a predetermined color, the mixture is assumed to be properly mixed.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: April 30, 2019
    Inventors: Austin Bonderer, Clark Levi
  • Patent number: 10022334
    Abstract: Cationic polymers are provided for delivering anionic active agents, preferably in the form or nanoparticles and other nanostructures. The polymer can be a polycation homopolymer or a copolymer containing a polycation block. The polycations and polycation containing polymers can contain dicarboxylic acid ester units and units of (a-amino acid)-?, ?-alkylene diester units. The nanoparticles can contain high loadings of anionic active agents, with sustained release of the active agents. Methods of making the polycations and polycation containing polymers are provided. Methods of making the nanoparticles and formulating them for administration to an individual in need thereof are also provided.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: July 17, 2018
    Assignee: The Brigham and Women's Hostpital, Inc.
    Inventors: Omid Farokhzad, Jun Wu, Lili Zhao
  • Patent number: 9795544
    Abstract: The subject of the present invention is a cosmetic composition of oil-in-water type comprising: (1) hydrophobic silica aerogel particles having a specific surface area per unit of mass (SM) ranging from 500 to 1500 m2/g and a size, expressed as volume-average diameter (D[0.5]), ranging from 1 to 1500 ?m ; (2) at least one gemini surfactant of formula (I): in which R1 and R3 denote, independently of one another, an alkyl radical containing from 1 to 25 carbon atoms; R2 denotes a spacer consisting of a linear or branched alkylene chain containing from 1 to 12 carbon atoms; X and Y denote, independently of one another, a —(C2H4O)a—(C3H6O)bZ group; n ranges from 1 to 10 ; and (3) at least one fatty phase comprising at least one fatty substance chosen from solid fatty substances and pasty fatty substances.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: October 24, 2017
    Assignee: L'Oreal
    Inventor: Raluca Lorant
  • Patent number: 9675556
    Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-lactate) that is crosslinked by at least one hydrolysable monomer. Another embodiment of the present invention is a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent. Another embodiment of the present invention is a polymer particle comprising, a crosslinked copolymer comprises structures represented by Formulas (I), (II), and (III), where Formulas (I), (II) and (III) are defined in the specification. Yet other embodiments of the present invention include a method of preparing a methacrylate terminated macromonomer, a method of preparing a crosslinking agent, and a method of preparing a therapeutic agent loaded nanosphere by dispersion polymerization.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: June 13, 2017
    Assignee: Howard University
    Inventors: Emmanuel Oyekanmi Akala, Simeon Kolawole Adesina
  • Patent number: 9670350
    Abstract: The present invention relates to novel polymer dispersants in the form of comb polymers P and to a liquid composition containing solid fine particles, such as organic or inorganic pigments and fillers, and the polymer dispersants. The comb polymer P having at least 0.5 mol-%, e.g. 0.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: June 6, 2017
    Assignee: BASF SE
    Inventors: Huiguang Kou, Clemens Auschra, Frank Pirrung, Matthias Maier, Dario Perera-Diez
  • Patent number: 9546235
    Abstract: The present invention relates to polymers, especially polymers useful as hydrogels, and to use of hydrogels for repair or restoration of tissue. In particular, the polymers and hydrogels of the present invention can be used for the repair or restoration of cartilage, especially articular cartilage. The polymers comprise at least a monomer for binding water, a monomer for imparting mechanical properties and a monomer for binding to an extracellular protein. The hydrogels comprise a polymer comprising at least a monomer for binding water and a monomer for binding to an extracellular protein. Crosslinking polymers by binding of said extra-cellular matrix protein forms hydrogels.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: January 17, 2017
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: Fariba Dehghani, Anthony Steven Weiss, Hua Wei, Suzanne Marie Mithieux, Ali Fathi
  • Patent number: 9522177
    Abstract: The present invention relates to an antimicrobial and immunostimulatory system, applications thereof and a process for the production of the antimicrobial and immunostimulatory system. The present invention provides a storage-stable antimicrobial and immunostimulatory system comprising an oxidoreductase enzyme, a substrate for the oxidoreductase enzyme and hydrogen peroxide in an aqueous solution wherein the substrate for the oxidoreductase enzyme is present up to 90% by weight and water is present up to 20% by weight based on the weight of the total composition; the system has a pH from approximately 4 to 8; and the system provides a two-stage hydrogen peroxide release.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: December 20, 2016
    Assignee: INSTITUTE OF TECHNOLOGY SLIGO
    Inventors: John Reginald Barrett, James Joseph Brennan, Thomas Patrick Patton
  • Patent number: 9415141
    Abstract: A method for the manufacture of biodegradable membranes for preventing adhesion formation followed open heart surgery is described herein. The manufacturing of biodegradable membranes is based on polymeric composition, comprised of copolymer of polyhydroxybutyrate/hydroxyvalerate (PHBV), poly (D, L-lactide) in the ratio of the dried powders of 3:1, the resulting mixture is dissolved in chloroform to a concentration of 6-9% followed by thorough mixing for 2 hours and heating up to 35° C. The membrane is produced by electrostatic spinning (electrospinning), wherein biologically active substances from fibrinolytic agents or direct anticoagulants are embedded in the structure of the fiber.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: August 16, 2016
    Assignee: Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases (NII KPSSZ)
    Inventors: Yuliya A. Kudryavtseva, Marina V. Nasonova, Leonid S. Barbarash
  • Patent number: 9174924
    Abstract: The present invention relates to the discovery of new class of linear and multiarmed hydrolysable linkers and cross linkers for use in the synthesis of biodegradable polymers such as, polyesters, polyurethanes, polyamides, polyureas and degradable epoxy amine resin. The linear and multiarmed hydrolysable linkers of the present invention include symmetrical and/or unsymmetrical ether carboxylic acids, amines, amide diols, amine polyols and isocyanates.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: November 3, 2015
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S Bezwada
  • Patent number: 9101552
    Abstract: A self-reversible reverse latex, and its use as a thickener. The self-reversible reverse latex includes: 50%-70 of a cross-linked polyelectrolyte obtained by the polymerization of a monomer of formula (I), with R1 being 8 to 20 carbon atoms and 1?n?30 for a neutral monomer, and a monomer having an acid function; 4%-10% of a water-in-oil emulsifier; 1%-10% of an oil-in-water emulsifier including a surface-active composition (C); 15%-45% oil; and 0%-5% water. Composition (C) is 10%-50% composition (CII) and 50%-90% composition(CIII). Composition(CII) is 60%-100% of a composition of formula (II), with R2 being a 12 carbon alkyl, T1, T2, and T3 being H or a (—CH2—CH2—O—)mi—H radical with 0?mi?10 and 0<?mi?10. Composition (CIII) is 60%-100% of a compound of formula (III) or mixtures of (III) and (IV), with R2 being as defined previously.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: August 11, 2015
    Assignee: SOCIETE DEXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC
    Inventors: Olivier Braun, Paul Mallo
  • Publication number: 20150147276
    Abstract: The invention provides compositions and methods for targeted controlled drug release. The compositions and methods can be used for treating or imaging vascular stenosis, stenotic lesions, occluded lumens, embolic phenomena, thrombotic disorders and internal hemorrhage.
    Type: Application
    Filed: June 7, 2013
    Publication date: May 28, 2015
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Donald E. Ingber, Netanel Korin, Mathumai Kanapathipilai, Oktay Uzun, Anne-Laure Papa
  • Publication number: 20150148431
    Abstract: A composition suitable for use in a transdermal delivery patch for administration of a biologically active compound, the composition comprising a phosphate compound of tocopherol and a polymer carrier.
    Type: Application
    Filed: November 21, 2014
    Publication date: May 28, 2015
    Inventors: Jeremy Cottrell, Giacinto Gaetano, Mahmoud El-Tamimy, Nicholas Kennedy, Paul David Gavin
  • Patent number: 9034390
    Abstract: The present invention generally relates to anti-microbial formulations and methods of their use and production. The formulations of the present invention are effective as broad spectrum anti-bacterial agents with efficacy against both Gram-negative and Gram-positive bacteria, as anti-viral agents with efficacy against both enveloped and non-enveloped viruses, and as anti-fungal agents with efficacy against both vegetative and spore forms of microorganisms and against biofilms. The present invention includes anti-microbial compositions that have at least one surfactant, at least one acid, at least one peroxide (preferably hydrogen peroxide), peracetic acid, and water. The anti-microbial Formulations of the present invention may additionally contain an organic salt. The organic salt may be a salt of the same acid that is used in the Formulation or a salt of a different acid. Methods for production and use of the inventive compositions are disclosed.
    Type: Grant
    Filed: May 10, 2007
    Date of Patent: May 19, 2015
    Assignee: BIONEUTRAL LABORATORIES CORPORATION
    Inventor: Andrew Kielbania, Jr.
  • Patent number: 9034355
    Abstract: A polymeric composition capable of releasing nitric oxide and modulating biological responses comprises a biocompatible polymer and S-nitrosated thiol bonded to the biocompatible polymer. The polymeric composition can have a thiol conversion of at least 40%. The polymeric composition can also have a nitric oxide recovery of at least 40% when under thermal decomposition conditions.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: May 19, 2015
    Assignee: Colorado State University Research Foundation
    Inventors: Melissa M. Reynolds, Vinod B. Damodaran
  • Publication number: 20150132346
    Abstract: A macroparticle pigment powder and methods of making the same. The macroparticle pigment powder comprises a plurality of macroparticle particles. The macroparticles are comprised of a matrix material that include pigment particles. In some embodiments the matrix material is polymeric in nature and selected from the group consisting of a natural latex, acrylics, polyacrylate, polymethacrylate, polyurethane, polyvinyl acetate, styrene-butadiene rubber, acrylonitrile butadiene styrene copolymer, and combinations thereof.
    Type: Application
    Filed: May 19, 2014
    Publication date: May 14, 2015
    Inventors: Yun Shao, Pascal Delrieu, David Schlossman, Frank Mazzella
  • Publication number: 20150133559
    Abstract: Methods for treating and preventing ocular conditions by administering an compound to the vitreous chamber of a patient at risk of, or suffering from, the ocular condition.
    Type: Application
    Filed: November 14, 2014
    Publication date: May 14, 2015
    Inventors: Scott M. Whitcup, David A. Weber
  • Patent number: 9029503
    Abstract: The invention mainly relates to a method for manufacturing a polypeptide of formula: X1—X?—X2??(III) X1 and X2 each representing a peptide fragment, and X? representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula: X1—N(CH2CH2SH)2??(I) and a polypeptide of formula: H—X?—X2.??(II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: May 12, 2015
    Assignees: Centre National de la Recherche Scientifique, Institut Pasteur de Lille
    Inventors: Oleg Melnyk, Reda Mhidia, Julien Dheur, Nathalie Ollivier
  • Publication number: 20150126615
    Abstract: Compositions of P4HB with high purity have been developed. The compositions are prepared by washing P4HB biomass prior to solvent extraction, and precipitating P4HB from solution. The same solvent is preferably used to wash the P4HB biomass, and as a non-solvent to precipitate the polymer from a P4HB solvent solution. The highly pure P4HB compositions are suitable for preparing implants. The implants may be used for the repair of soft and hard tissues.
    Type: Application
    Filed: October 31, 2014
    Publication date: May 7, 2015
    Inventors: David P. Martin, Simon F. Williams
  • Patent number: 9023898
    Abstract: A flushing solution is described which is suitable for use in surgical, in particular ophthalmological, operations and which contains a non-Newtonian fluid. The use of such a flushing solution is also described. The flushing solution can be used as an intraoperative instrument, particularly as an instrument for manipulating intraocular structures such as retina.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: May 5, 2015
    Assignee: Fluoron GmbH
    Inventors: David Wong, Christian Lingenfelder
  • Publication number: 20150118268
    Abstract: A metal-organic compound containing polymer matrix includes a polymer and a three-dimensional metal-organic framework includes a polydentate organic linker. The metal-organic compound containing polymer matrix is configured to continuously produce nitric oxide when exposed to a physiological fluid including a nitric oxide-releasing compound via a catalytic reaction catalyzed by the three-dimensional metal-organic framework.
    Type: Application
    Filed: January 15, 2015
    Publication date: April 30, 2015
    Inventors: Melissa M. Reynolds, Benjamin P. Reynolds
  • Publication number: 20150119792
    Abstract: A system and method for delivering a payload to ocular tissue includes a solution of light-degradable nanoparticles encapsulating the payload. The solution may be introduced to the ocular tissue by way of injection or through a contact lens into which the solution is embedded. A light source delivers a beam of light to the ocular tissue at the location where the solution was introduced to initiate breakdown of the particles, releasing the payload. The light source may be a laser, LED, LCD or arc lamp emitting in the ultraviolet light range.
    Type: Application
    Filed: March 8, 2013
    Publication date: April 30, 2015
    Applicant: The Regents of the University of California
    Inventors: Adah Almutairi, Viet Anh Nguyen Huu, Cathryn McFearin, Enas Mahmoud
  • Publication number: 20150118152
    Abstract: Compositions of P4HB (poly-4-hydroxybutyrate) and copolymers thereof, have been developed for pultrusion, as well as processes to produce profiles from these compositions by pultrusion. These pultrusion processes provide profiles without causing structural damage to the surface of the profile. The profiles may be used in medical applications. These compositions include P4HB, and copolymers thereof, having intrinsic viscosities less than 3.2 dl/g but greater than 0.8 dl/g. The profile may be formed using conditions such as: pull rate of 0.1 to 100 mm/min, die temperature of up to 95° C., rod stock temperature up to 95° C., draw ratio of up to 100×, pulling force of greater than 10 MPa, and clamping pressure at least 10% higher than the pulling force. Preferably, the profile is formed by pulling the rod stock through a series of dies placed at intervals with the hole sizes decreasing in diameter by 0.1 to 10 mm.
    Type: Application
    Filed: October 30, 2014
    Publication date: April 30, 2015
    Inventors: Amit Ganatra, Bhavin Shah, Said Rizk, David P. Martin, Simon F. Williams
  • Publication number: 20150118320
    Abstract: One of the purposes of the present invention is to provide an aqueous dispersion of silicone elastomer particles to provide a stable emulsion and the silicone elastomer particle, wherein a polyoxyethylene alkyl ether which has an alkyl group having a large number of carbon atoms is used as a surfactant. Further, another purpose is to provide a cosmetic comprising said aqueous dispersion or said silicone elastomer particles and giving a good feeling in the use. The present invention provides an aqueous dispersion comprising (A) silicone elastomer particles having a 90% volume cumulative diameter (D90) of 0.3 to 20 ?m in an amount of 5 to 80 mass %, based on a total mass of the aqueous dispersion, (B) at least one polyoxyethylene alkyl ether having an alkyl group having 18 carbon atoms in an amount of 0.01 to 15 mass %, based on a total mass of the aqueous dispersion, wherein a hydrophile-lipophile balance (HLB) of the polyoxyethylene alkyl ether is 12.8 to 15.
    Type: Application
    Filed: October 28, 2014
    Publication date: April 30, 2015
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Yoshinori INOKUCHI, Ryuji HORIGUCHI, Chihiro HAYAKAWA, Masayuki KONISHI
  • Patent number: 9017702
    Abstract: A formulation includes one or more active ingredients of poor water solubility for medical or non-medical use in the rearing of animals. The formulation is suitable for administration to the animals via their drinking water. It exhibits superior stability. The formulation comprises an active ingredient, a thickener combination and water, wherein the thickener combination comprises at least one thickener selected from the following groups A, B, C and D: (A) cellulose derivatives, such as methyl cellulose, sodium carboxy methyl cellulose, (B) non-cellulosic polysaccharide thickeners such as xanthan gums, Arabic gum, (C) cross-linked polyacrylic acid polymers, (D) hydrocolloidal hydrated silicates.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: April 28, 2015
    Assignee: KRKA, D.D., Novo Mesto
    Inventors: Denise Leskovar, Franc Vrecer, Andrejka Kramar, Ivanka Kolenc, Ivan Gobec, Helena Princ
  • Patent number: 9017644
    Abstract: The present invention relates to dendrimer compositions configured for treating inflammatory disorders and autoimmune disorders, and related methods of synthesis. Specifically, the present invention relates to methods for treating rheumatoid arthritis with PAMAM dendrimers having functional ligands configured for treating rheumatoid arthritis (e.g., therapeutic agents, pro-drugs, targeting agents, trigger agents, imaging agents) (e.g., methotrexate).
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: April 28, 2015
    Assignee: The Regents of the University of Michigan
    Inventors: James R. Baker, Jr., Larry A. Sternson, David Repp, Deborah Ladenheim
  • Publication number: 20150111812
    Abstract: Hydrogels and hybrid hydrogels, methods of making the hydrogels/hybrid hydrogels, and methods of using the hydrogels/hybrid hydrogels. The hydrogels have polysaccharide moieties (e.g., chitosan or hyaluronic acid moieties). The hybrid hydrogels have polysaccharide moieties (e.g., chitosan or hyaluronic acid moieties) and poly(ester amide) moieties. The poly(ester amide) moieties can have one or more arginine moieties. The hydrogels/hybrid hydrogels can be used, for example, in consumer products and as cargo carrier materials (e.g., as therapeutic agent carriers).
    Type: Application
    Filed: May 31, 2013
    Publication date: April 23, 2015
    Inventors: Chih-Chang Chu, DeQun Wu, Mingyu He
  • Publication number: 20150110772
    Abstract: The invention provides hydrogel, wherein the hydrogel has a supramolecular cross-linked network obtainable or obtained from the complexation of an aqueous composition including a host, such as cucurbituril, and one or more polymers having suitable guest functionality. One or more polymers in the aqueous composition may have a molecular weight of 50 kDa or more, such as 200 kDa or more. The hydrogel may hold a component, such as a therapeutic compound or a biological molecule. The hydrogels are suitable for use in medicine.
    Type: Application
    Filed: February 20, 2013
    Publication date: April 23, 2015
    Inventors: Oren Scherman, Eric Appel, Xian Jun Loh, Frank Biedermann, Matthew Rowland
  • Publication number: 20150112244
    Abstract: Otologic materials and methods are provided. For example, a cell-adhesive, biodegradable hydrogel scaffold loaded with time-released drugs for repairing chronic tympanic membrane perforations is disclosed, methods of making same and administering same are provided. This hydrogel may promote vascular in-growth and epithelial cell growth of the tympanic membrane with the purpose of closing the perforation and providing a barrier between the external and middle ear. The hydrogel is initially a liquid polymer that only gels upon exposure to specific conditions, such as exposure to light. This scaffold may simultaneously induce repair of the tympanic membrane while preventing or alleviating middle ear infection, thus filling a void in current tympanic membrane perforation therapies.
    Type: Application
    Filed: December 28, 2014
    Publication date: April 23, 2015
    Applicant: The Administrators of the Tulane Educational Fund
    Inventors: Elaine Horn-Ranney, Parastoo Khoshakhlagh, Michael Moore, Jesse Ranney
  • Patent number: 9012424
    Abstract: The present invention relates to a polymer according to Formulas (1) or (2): The present invention further relates to nanogels and nanoparticles made of a polymer according to general Formulas (1) and (2). The nanogels may comprise a biologically active component such as siRNA, miRNA, DNA, an (oligo)peptide or a proteins.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: April 21, 2015
    Assignee: 20MED Therapeutics B.V.
    Inventors: Johannes Franciscus Joseph Engbersen, Arkadi Vladimirovich Zinchenko
  • Patent number: 9012677
    Abstract: The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: April 21, 2015
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S Bezwada
  • Publication number: 20150100086
    Abstract: A composition includes polydioxanone and/or a copolymer thereof and at least one carboxylic salt. A molding includes the composition. A thread includes the composition. A medical kit includes the composition and a medical product includes the composition.
    Type: Application
    Filed: March 28, 2013
    Publication date: April 9, 2015
    Applicant: ITV Denkendorf Produktservice GmbH
    Inventors: Sven Oberhoffner, Erhard Müller
  • Patent number: 8999378
    Abstract: The present invention provides porous electroactive hydrogels, the deformation angle of which is controlled by electroactuation, and methods for preparing and using such hydrogels.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: April 7, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Kevin Kit Parker, Megan O'Grady
  • Patent number: 9000053
    Abstract: A method of producing an emulsion includes preparing a droplet solution comprising first and second molecular species, the droplet solution being in a fluid phase, wherein the first molecular species is soluble in the second molecular species; forming a plurality of droplets from the droplet solution in a bulk fluid to create a first emulsion, the plurality of droplets having a first ensemble average radius in the bulk fluid, wherein the first molecular species of the droplet solution is at least partially soluble in the bulk fluid and the droplet solution is at least partially immiscible in the bulk fluid; and allowing molecules of the first molecular species to migrate from the plurality of fluid droplets to the bulk fluid due to a higher concentration of the first molecular species in the droplet solution than the bulk fluid to result in the plurality of droplets having a second ensemble average radius that is smaller than the first ensemble average radius.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: April 7, 2015
    Assignee: The Regents of the University of California
    Inventors: Thomas G. Mason, Michael M. Fryd
  • Patent number: 9000052
    Abstract: A perfuming composition capable of prolonging the release of a perfuming component into the surrounding environment when applied on a surface. This composition utilizes hydrophobic block copolymers in the presence of high amounts of ethanol. The invention also relates to consumer articles containing such compositions. It finally provides methods for the perfuming of a surface and a method for increasing the long-lastingness of a perfuming component using these compositions.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: April 7, 2015
    Assignee: Firmenich SA
    Inventors: Damien Berthier, Sébastien Lecommandoux, Isabelle Schmidt, Christophe Schatz
  • Patent number: 8992991
    Abstract: Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: March 31, 2015
    Assignee: The Johns Hopkins University
    Inventors: Jordan J. Green, Joel C. Sunshine, Nupura S. Bhise, Ron B. Shmueli, Stephany Y. Tzeng
  • Patent number: 8993831
    Abstract: Medical implants and methods useful in treating postpartum hemorrhage are disclosed. The implants, in some embodiments, comprise polyurethane foams having advantageous mechanical and other properties selected to promote hemostasis when brought in contact with an inner wall of a uterus. Methods of making and deploying such implants are also disclosed.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: March 31, 2015
    Assignee: Arsenal Medical, Inc.
    Inventors: Upma Sharma, Irina Gitlin, Parisa Zamiri, Toby Freyman, Rany Busold, Lee Core, Janet Chie Komatsu, Jennifer Mortensen
  • Patent number: 8987339
    Abstract: Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydrogel polymer is delivered into a joint space to treat joint disease or navicular disease.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 24, 2015
    Assignee: Medicus Biosciences LLC
    Inventors: Syed H. Askari, Yeon S. Choi
  • Publication number: 20150080301
    Abstract: Disclosed are novel bioabsorbable and biodegradable monomer compounds, bioabsorbable and biodegradable polymers therefrom, and methods of making such monomers and polymers, which are useful in pharmaceutical delivery systems, tissue engineering applications, tissue adhesives products, implantable medical devices, foams and reticulated foams for wound healing and drug delivery, bone hemostats and bone void fillers, adhesion prevention barriers, meshes, filters, stents, medical device coatings, pharmaceutical drug formulations, consumer product and cosmetic and pharmaceutical packaging, apparel, infusion devices, blood collection tubes and devices, other medical tubes, skin care products, and transdermal drug delivery materials.
    Type: Application
    Filed: November 20, 2014
    Publication date: March 19, 2015
    Inventor: Rao S. Bezwada
  • Patent number: 8980957
    Abstract: The subject invention relates to a method of preparing a biocompatible polymer comprising epsilon-linked L-lysine having free alpha-amino and carboxy functions. The invention further encompasses the resulting biocompatible polymer and articles made from the polymer, in particular contact and intraocular lenses.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: March 17, 2015
    Assignee: CIS Pharma AG
    Inventors: Rolf Schäfer, Hans Hitz
  • Patent number: 8980278
    Abstract: The present invention is directed to a bio-functionalized stimulus-responsive dissolvable PEG-hydrogel. This inventive stimulus-responsive dissolvable PEG-hydrogel comprises a matrix of PEG-polymers, which are modified to contain at least one multifunctional fusion protein, the multifunctional fusion protein preferably comprising as components a substrate binding peptide (SBP), preferably a repetitive RGD-binding peptide and/or a ZZ-binding domain, preferably a tag for purification, and at least one N- and/or C-terminal linker. The present invention is furthermore directed to the use of such inventive stimulus-responsive dissolvable PEG-hydrogels in the treatment of lesions, in surgical dressings, for wound treating, for soft and hard tissue regeneration, for the treatment of wounds in the oral cavity, in the field of ophthalmology, in the field of periodontal defects, etc. The invention also describes a method of treatment for such diseases.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: March 17, 2015
    Assignees: Universitaetsklinikum Freiburg, Albert-Ludwigs-Universitaet Freigburg
    Inventors: Thorsten Steinberg, Wilfried Weber, Raphael Guebeli, Pascal Tomakidi, Dougal Laird
  • Publication number: 20150071981
    Abstract: The present invention provides compositions for extended release of an active ingredient, comprising a lipid-saturated matrix formed from a biodegradable polymer. The present invention also provides methods of producing the matrix compositions and methods for using the matrix compositions to provide controlled release of an active ingredient in the body of a subject in need thereof.
    Type: Application
    Filed: October 26, 2014
    Publication date: March 12, 2015
    Inventor: Noam EMANUEL
  • Publication number: 20150065442
    Abstract: Reductively degradable micelles comprising poly(-?amino ester)s-g-poly(ethylene glycol) amphiphilic copolymers provided with aromatic phenylbutylamine side groups, suitable for sequestering therein anthrocyclines. The anthrocycline-loaded reductively degradable micelles are useful for therapeutic treatment of cancers.
    Type: Application
    Filed: January 15, 2013
    Publication date: March 5, 2015
    Inventor: Malcolm M.Q. Xing
  • Patent number: 8968783
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: March 3, 2015
    Assignee: Covidien LP
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla
  • Patent number: 8968782
    Abstract: The present invention relates to relates to combination degradable and non-degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix including a degradable polymer network, a non-degradable polymer network, the non-degradable polymer network interspersed within the degradable polymer network, and an active agent. In an embodiment, the invention includes an active agent elution control matrix including a degradable polymer; and a non-degradable polymer interspersed with the degradable polymer. In an embodiment, the invention includes a method of making an active agent delivery matrix including mixing a degradable polymer with a first solvent to form a degradable polymer solution; mixing a non-degradable polymer with a second solvent to form a non-degradable polymer solution; and simultaneously depositing the degradable polymer solution and the non-degradable polymer solution onto a substrate.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: March 3, 2015
    Assignee: SurModics, Inc.
    Inventors: Ralph A. Chappa, Robert W. Hergenrother, Paula Bushendorf, Joram Slager
  • Publication number: 20150057368
    Abstract: Methods to produce substantially closed cell foams with densities less than 0.75 g/cm3, and more preferably less than 0.5 g/cm3, without substantial loss of the polymer's weight average molecular weight, have been developed. The closed cells foams have an open cell content of generally less than 50%, and more preferably an open cell content of less than 20%, and the cells have a maximum diameter of less than 5 mm. The foam may include poly-4-hydroxybutyrate or a copolymer thereof. Preferably, the foam is derived by heating a foam polymer formula to a temperature above the melt temperature of the polymer to form a melt polymer system, adding a blowing agent to produce a foamable melt, extruding the foamable melt through a die to a lower pressure to cause foaming, cooling of the foam, and solidification of the foam. These foam structures can be used for fabrication of medical products.
    Type: Application
    Filed: August 20, 2014
    Publication date: February 26, 2015
    Inventors: Dennis Connelly, Fabio Felix, David P. Martin, Jon Montcrieff, Said Rizk, Simon F. Williams
  • Publication number: 20150056131
    Abstract: Methods to produce thermoforms from P4HB homopolymer and blends thereof have been developed. These thermoforms are produced from films and sheets including P4HB, wherein the intrinsic viscosity of the P4HB is less than 3.5 dl/g, but greater than 0.35 dl/g, and the thermoforms are produced at a temperature equal to or greater than the softening point of P4HB, and more preferably at a temperature higher than the melting point of P4HB. A preferred embodiment includes a P4HB thermoform wherein a film or sheet including a P4HB polymer is thermoformed at a temperature between its melting point and 150° C. In a particularly preferred embodiment the thermoform is a laminate made from a P4HB film and a P4HB mesh.
    Type: Application
    Filed: August 20, 2014
    Publication date: February 26, 2015
    Inventors: Matthew Bernasconi, Dennis Connelly, Said Rizk, David P. Martin, Simon F. Williams
  • Patent number: 8956638
    Abstract: A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine in an aprotic solvent. The resulting poly(amic acid) composition is suitable as a biocompatible material, such as a biomedical implant, implant coating material, tissue scaffold material, controlled release drug delivery vehicle, and cellular growth substrate.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: February 17, 2015
    Assignee: Axcelon Biopolymers Corporation
    Inventors: Wankei Wan, Donna Padavan