Gelatin Or Derivative Patents (Class 514/774)
  • Patent number: 9439940
    Abstract: The present invention relates to liquid application for skin rejuvenation created from specific amino acids, lipids, nucleic acids and vitamins. This collection of molecules delivers precisely the factors necessary to a specific site requiring healing; a direct intervention system to most expeditiously remodel skin with building blocks. This delivery is a transdermal topical delivery and healing is via specific molecules that engender a false autocoid reaction rapidly followed by an incremental healing-anti-inflammatory response augmented by very specific GRAS ingredients in the invention and also recruited from the body to this needy site. Energy is brought to site by transdermally delivered protons and enhanced by the local vascular flow initiated by transdermal molecules. This delivery system bypasses digestion and dilution. Key is a lipophilic carrier with nuclear and mitochondrial ligands that rapidly penetrate and permeate all membranes and truncates the inflammatory site quickly manifesting curation.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: September 13, 2016
    Assignee: Neville Pharmaceutical, Inc.
    Inventor: Donald P. Orofino
  • Patent number: 9415060
    Abstract: Disclosed is a gelatin-based nanoparticle complex for tumor-targeted delivery of siRNA for specific gene silencing in tumor cells. The gelatin-based nanoparticle complex includes: poly-siRNA chains whose ends are modified with thiol groups; and thiolated gelatin bound to the poly-siRNA chains through disulfide crosslinking and charge interactions. The gelatin-based nanoparticle complex is not degraded in the bloodstream and can be efficiently absorbed into tumor cells without cytotoxicity. The delivered siRNA can effectively silence target gene expression. Also disclosed is a method for preparing the gelatin-based nanoparticle complex.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: August 16, 2016
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Kwang Meyung Kim, Sun Hwa Kim, Ick Chan Kwon, Ji Young Yhee, Sojin Lee
  • Patent number: 9168218
    Abstract: Disclosed are cosmetic compositions and methods for making up keratinous tissue using the compositions, as well as methods of making the compositions. The compositions contain a photoluminescent polymer (PLP) which is an oligomeric polyester synthesized from a multifunctional monomer and a diol, and which has grafted thereon an amino acid or an amino acid derivative. The compositions achieve a colorizing and/or UV-protectant effect when applied to keratinous tissue.
    Type: Grant
    Filed: January 25, 2012
    Date of Patent: October 27, 2015
    Assignee: L'OREAL S.A.
    Inventors: Emmanuel Dimotakis, Hy Si Bui, Jean-Thierry Simonnet, Mohamed Kanji
  • Publication number: 20150118195
    Abstract: The presently disclosed subject matter provides a scalable and electrostretching approach for generating microfibers exhibiting uniaxial alignment from polymer solutions. Such microfibers can be generated from a variety of natural polymers or synthetic polymers. The hydrogel microfibers can be used for controlled release of bioactive agents. The internal uniaxial alignment exhibited by the presently disclosed fibers provides improved mechanical properties to microfibers, contact guidance cues and induces alignment for cells seeded on or within the microfibers.
    Type: Application
    Filed: April 30, 2013
    Publication date: April 30, 2015
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Hai-Quan Mao, Shuming Zhang, Xi Liu, Brian Patrick Ginn
  • Patent number: 8980295
    Abstract: Biomaterials that support cell attachment and growth are provided. In one aspect, biomaterials are provided comprising a first polymer matrix comprising reactive amino moieties and a second polymer matrix that interpenetrates with the first polymer matrix, where the second polymer matrix comprises a poly(alkylene oxide) comprising two or more alkylene oxide oligomers joined by gamma-thioether carbonyl linkages. In another aspect, biomaterials are provided comprising at least one biopolymer comprising amino groups, thiol groups, and bifunctional modifiers connecting at least some of the amino groups to at least some of the thiol groups; and at least one poly(alkylene oxide) cross-linked to at least two thiol groups of the biopolymer. The biomaterials may further comprise a pharmacologically active agent or cells. Methods of administering such biomaterials to a patient in need thereof are also provided.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: March 17, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Weiyuan J. Kao, Yao Fu
  • Patent number: 8968783
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: March 3, 2015
    Assignee: Covidien LP
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla
  • Publication number: 20150057370
    Abstract: A drug composition in a liquid form sealed within a soft capsule containing succinylated gelatin as a principal component thereof, the composition including (a) one kind of phenol derivative or a mixture of multiple kinds thereof and (b) a succinylated-gelatin insolubilizing agent; and a soft capsule drug including a capsule shell containing succinylated gelatin as a principal component thereof, the shell sealing therein a drug composition in a liquid form including (a) one kind of phenol derivative or a mixture of multiple kinds thereof; and (b) a succinylated-gelatin insolubilizing agent.
    Type: Application
    Filed: March 19, 2013
    Publication date: February 26, 2015
    Applicant: TAIKO PHARMACEUTICAL CO., LTD.
    Inventors: Yuji Yoneda, Kaori Nakagawa
  • Publication number: 20150050334
    Abstract: The present invention relates to new acid resistant hard pharmaceutical capsules, a process for their manufacture and use of such capsules particularly but not exclusively for oral administration of pharmaceuticals, veterinary products, food and dietary supplements to humans or animals. The capsules of the invention are obtained by aqueous compositions comprising a water soluble film forming polymer and gellan gum in a mutual weight ratio of 4 to 15 weight parts of gellan gum for 100 weight parts of film forming polymer.
    Type: Application
    Filed: August 27, 2014
    Publication date: February 19, 2015
    Inventors: Dominique Nicolas Cade, Xiongwei David He
  • Patent number: 8951570
    Abstract: An extrusion process comprises extruding a material that is flowable when heated and passing the extrudate thus formed through a nozzle 10 to shape the extrudate into a plurality of substantially uniformly shaped elements such as minispheres or minicapsules.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: February 10, 2015
    Assignee: Sigmoid Pharma Limited
    Inventor: Ivan Coulter
  • Publication number: 20150037314
    Abstract: Disclosed is a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. Further disclosed are methods of preparing said dry composition, a paste made from said dry composition and use of said paste for medical and surgical purposes.
    Type: Application
    Filed: October 17, 2014
    Publication date: February 5, 2015
    Inventor: Kristian Larsen
  • Patent number: 8927015
    Abstract: Oral insulin formulations and processes for preparing oral insulin formulations are provided.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: January 6, 2015
    Assignee: Emisphere Technologies, Inc.
    Inventors: Halina Levchik, Moses O. Oyewumi, Shingai Majuru, William Elliott Bay, Jun Liao, Puchun Liu, Steven Dinh, Nikhil Dhoot
  • Patent number: 8920842
    Abstract: The present invention relates a biopolymeric liquid aqueous composition for producing self-gelling systems and gels, which comprises: an acidic water-based medium, 0.1 to 10% by weight of a pH-gelling acid-soluble biopolymer; and 0.1 to 10% by weight of a water-soluble molecule having a basic character and a pKa between 6.0 and 8.4, or a water-soluble residue or sequence of the molecule having a basic character and a pKa between 6.0 and 8.4. The liquid composition has a final pH ranging from 5.8 and 7.4, and forms a stable solid and homogeneous gel within a temperature range from 10 to 70° C. The present invention also relates to a method for preparing the composition and uses thereof.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: December 30, 2014
    Assignee: Piramal Healthcare (Canada) Ltd.
    Inventors: Abdellatif Chenite, Cyril Chaput, Dong Wang, Amine Selmani
  • Publication number: 20140371145
    Abstract: A scaffold for vascular endothelial cell migration includes a recombinant gelatin having an amino acid sequence derived from a partial amino acid sequence of collagen. A method for producing a blood vessel uses this scaffold.
    Type: Application
    Filed: July 25, 2014
    Publication date: December 18, 2014
    Inventors: Reiko IWAZAWA, Kentaro NAKAMURA
  • Publication number: 20140341842
    Abstract: The invention provides methods, compositions and kits relating to hyaluronan based matrices using oxidized glutathione as a crosslinking agent.
    Type: Application
    Filed: May 12, 2014
    Publication date: November 20, 2014
    Inventors: Thomas Zarembinski, Isaac Erickson, Nathaniel Doty
  • Patent number: 8883221
    Abstract: Micronutrient combination product, wherein the micronutrient combination product comprises zeaxanthin, lutein, zinc and copper.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: November 11, 2014
    Assignee: Bausch & Lomb Incorporated
    Inventors: Guenter Bellmann, Gudrun Claus-Herz
  • Publication number: 20140329915
    Abstract: The present invention provides compositions and methods useful in the treatment of wounds, particularly in reducing or preventing scar formation, particularly hypertrophic scar or keloid formation. The invention thus further provides methods of treatment, including methods useful in hypertrophic scar or keloid revision as well as prophylactic, scar inhibiting methods.
    Type: Application
    Filed: April 30, 2014
    Publication date: November 6, 2014
    Applicant: Halscion, Inc.
    Inventors: Tien Nguyen, Kathleen Prudhomme, Ronald Yamamoto, Adam G. Lowe, Andrew Michael Green
  • Patent number: 8877158
    Abstract: It is an object of the present invention to provide a targeting agent that enables drug delivery to a neovascular site and the imaging of such a neovascular site, utilizing the effect of the agent to accumulate in the neovascular site. The present invention provides a targeting agent to a neovascular site, which comprises a gelatin-like protein.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: November 4, 2014
    Assignees: FUJIFILM Corporation, Kyoto University
    Inventors: Kentaro Nakamura, Yasuhiko Tabata
  • Patent number: 8871267
    Abstract: The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to protein matrix materials and devices that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, encapsulated or coated stent devices, vessels, tubular grafts, vascular grafts, wound healing devices including protein matrix suture material and meshes, skin/bone/tissue grafts, biocompatible electricity conducting matrices, clear protein matrices, protein matrix adhesion prevention barriers, cell scaffolding and other biocompatible protein matrix devices. Furthermore, the present invention relates to protein matrix materials and devices made by forming a film comprising one or more biodegradable protein materials, one or more biocompatible solvents and optionally one or more pharmacologically active agents.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: October 28, 2014
    Assignee: Gel-Del Technologies, Inc.
    Inventor: David B. Masters
  • Publication number: 20140316013
    Abstract: The present invention relates to a crosslinked gelatin support, in which a surface of a crosslinked gelatin is negatively charged and has a zeta potential in ethanol of from ?3 to ?50 mV, and a support for controlled release of a physiologically active substance, including: the crosslinked gelatin support; and a physiologically active substance adsorbed and retained on and/or inside the crosslinked gelatin support.
    Type: Application
    Filed: April 18, 2014
    Publication date: October 23, 2014
    Applicant: NITTO DENKO CORPORATION
    Inventors: Shinji SUGAWARA, Chieko MIURA, Tomoko SUDO, Masao NAKAGAWA, Toshiyuki YOSHIKAWA
  • Publication number: 20140294770
    Abstract: The present invention features, inter alia, biocompatible compositions that include a poloxamer and one or more additives such as hyaluronic acid, gelatin, fibronectin, or a peptide fragment of fibronectin. The compositions are useful in tissue repair or remodeling, including repair of an injured spinal disc, in drug delivery, in cell culture, and in inhibiting the formation of adhesions.
    Type: Application
    Filed: July 5, 2012
    Publication date: October 2, 2014
    Applicant: The Research Foundation of State University of New York
    Inventors: Raphael Davis, Divya Bhatnagar, Miriam Rafailovich
  • Publication number: 20140271521
    Abstract: A process for forming a personal care article, the process including (a) producing an extrudate from a twin screw extruder, and (b) forming the extrudate into the personal care article. The personal care article includes (i) from about 10% to about 60% of one or more anionic surfactants, wherein the one or more anionic surfactants have a Krafft point of less than 30° C.; (ii) from about 10% to about 50% of one or more water soluble polymers; (iii) from about 1% to about 30% of one or more plasticizers; and (iv) from about 10% to about 50% water.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Robert Wayne GLENN, JR., Todd Ryan THOMPSON, Ungyeong JUNG, Changwei ZHU, Alireza TABATABAEI-NAEINI
  • Patent number: 8822551
    Abstract: Disclosed herein is a hyaluronic acid epoxide derivative film comprises a polymer containing a hydroxyl (—OH) terminal group. The film is prepared by allowing an epoxy crosslinker to react with a mixture of hyaluronic acid and a polymer containing a hydroxyl (—OH) terminal group and has improved physical strength, in vivo stability, flexibility, adhesiveness to biological tissue, and biocompatibility.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: September 2, 2014
    Assignee: Genewel Co., Ltd.
    Inventors: Young Woo Lee, Wan Jin Cho, Ji Yeon Jang
  • Publication number: 20140243429
    Abstract: The present invention belongs to the biomedicine field and specifically concerns an enzyme-degradable polymer and the application thereof. To solve the problem of low sensitivity of the existing assay reagents, the present invention provides an enzyme-degradable polymer and the related application of the polymer. The present invention also provides hydrogels, nano-particles, fluorescent dye-labeled enzyme substrates and kits (packages) for detection or activity-analysis of biological enzymes based on the enzyme-degradable polymer. The formula of the enzyme-degradable polymer is P1-(aa)N-(AA)n-X X=[formula 1] wherein, (aa)N is a non-enzyme substrate domain, the N aa may be different (no correlation), and N is a non-negative integer; (AA)n is an enzyme substrate domain, the n AA may be different, and n is a non-negative integer; P1 is a protecting group of ?-amino or functional group; P2 is a protecting group of ?-amino; P3 is —NH2, a small molecule compound or a fragment of a polymer.
    Type: Application
    Filed: May 24, 2011
    Publication date: August 28, 2014
    Inventor: Lijun Dai
  • Publication number: 20140242024
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Application
    Filed: May 8, 2014
    Publication date: August 28, 2014
    Applicant: Covidien LP
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla, Timothy Sargeant, Joshua Stopek
  • Patent number: 8815320
    Abstract: A process for producing a composition containing biologically active follistatin from a biological source, which composition is preserved and, especially pathogen free and is storage stable, preferably at room temperature. Further, the invention relates to the composition containing biologically active follistatin, which composition is available by the production process. The invention provides a process for producing a composition containing biologically active follistatin from avian eggs, or from raw animal blood serum.
    Type: Grant
    Filed: February 12, 2013
    Date of Patent: August 26, 2014
    Assignee: Myos Corporation
    Inventors: Waldemar Buxmann, Volker Heinz, Stefan Toepfl
  • Patent number: 8785389
    Abstract: This invention relates to the production of biomaterials from polymeric collagen (PC) and its seeding with cells and other components of biomaterials. Polymeric collagen is isolated from tissue, suspended in an acidic solution, and then neutralized at low temperature. The neutralized suspension is then seeded with biomaterial components, such as cells, and the polymeric collagen aggregated to form a biomaterial comprising the biomaterial components. Polymeric collagen biomaterials produced as described herein may therefore be useful in a range of tissue engineering applications.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: July 22, 2014
    Assignee: UCL Business PLC
    Inventors: Robert Brown, Burcak Alp, Hector Hadjipanayi
  • Publication number: 20140179803
    Abstract: A continuous process for the preparation of gelatin based nanoparticles in a reactor having a process channel having a mixing element therein, the process having the following steps: A) feeding separately an aqueous gelatin solution at a first rate and a water-miscible organic solvent at a second rate to the process channel of the reactor to be mixed therein, to form a suspension of non-crosslinked gelatin based nanoparticles and B) crosslinking the non-crosslinked gelatin based nanoparticles, wherein the sum of the first rate and the second rate is chosen such that the reactor has a mixing efficiency as determined by the Villermaux/Dushman method of between 0.1 and 1.5 and the period from the time point at which the aqueous gelatin solution is fed to the reactor to the time point at which the mixture of the aqueous gelatin solution and the organic solvent contacts the mixing element is at most 15 seconds.
    Type: Application
    Filed: July 2, 2012
    Publication date: June 26, 2014
    Applicant: FURTURECHEMISTRY HOLDING B.V.
    Inventors: Sebastiaan Antonius Martinus Waltherus Van Den Broek, Pieter Jos Nieuwland, Kaspar Koch
  • Publication number: 20140154212
    Abstract: Hydrogels based on gelatin crosslinked with N,N?-methylenebisacrylamide (MBA) are disclosed. The hydrogels according to the invention are useful for cell culture, growth and proliferation, for the controlled release of bioactive molecules, and to promote tissue regeneration.
    Type: Application
    Filed: May 31, 2012
    Publication date: June 5, 2014
    Applicant: POLITECNICO DI MILANO
    Inventors: Maria Cristina Tanzi, Silvia Fare, Irini Gerges
  • Patent number: 8741969
    Abstract: An object of the present invention is to provide an anti-adhesion membrane that has no toxicity to a living body, has flexibility allowing itself to fit an affected part as a hydrated gel, is uniformly crosslinked, and is immediately absorbed in a living body after maintaining its shape in the living body for a certain period of time. The present invention provides anti-adhesion material, which comprises a thermally crosslinked gelatin film, and has a water content of 60 to 85% calculated by the following formula (1): water content (%)=[(Ws?Wd)/Ws]×100(%)??(1), in the formula (1), Ws representing a weight (wet weight) of the anti-adhesion material immersed in a phosphate buffered saline solution at a temperature of 25° C. for one hour, and Wd representing a weight (dry weight) of the anti-adhesion material dried completely using a vacuum drying apparatus.
    Type: Grant
    Filed: August 2, 2006
    Date of Patent: June 3, 2014
    Assignee: Gunze Limited
    Inventors: Hitoshi Otani, Shojiro Matsuda, Tsuguyoshi Taira, Noriyuki Morikawa
  • Publication number: 20140141076
    Abstract: The present invention provides: a soft capsule preparation which includes a self-emulsifying composition containing an oily component, an emulsifier, 8% by mass to 20% by mass of a polyhydric alcohol and 2.5% by mass to 5% by mass of water, and a capsule film containing 35% by mass to 50% by mass of a polyhydric alcohol and gelatin, in which capsule film the above-described self-emulsifying composition is encapsulated; a method of producing the soft capsule preparation; a composition for a soft capsule preparation, which is an intermediate product of the soft capsule preparation; and a self-emulsifying composition and a capsule film composition that are used in the composition for a soft capsule preparation.
    Type: Application
    Filed: January 28, 2014
    Publication date: May 22, 2014
    Applicant: FUJIFILM CORPORATION
    Inventors: Nobuyuki HARAGUCHI, Hiroyuki SAKAGUCHI
  • Publication number: 20140112972
    Abstract: Provided is an adhesion preventing medical material including a bioresorbable base material and a polyhydric alcohol or aqueous polyhydric alcohol solution, which contains the polyhydric alcohol, held in the bioresorbable base material. The bioresorbable base material includes a bioresorbable material, and has a swelling degree of 200 to 3,000 mass % and a water elution rate of not higher than 10 mass %. After immersed for 3 hours in water of 25° C. in an amount at least 50 times a total mass of the aqueous polyhydric alcohol solution or aqueous polyhydric alcohol solution and the bioresorbable base material, the polyhydric alcohol remains in an amount of not greater than 30 mass % of that of the polyhydric alcohol before the immersion.
    Type: Application
    Filed: January 2, 2014
    Publication date: April 24, 2014
    Applicant: Dainichiseika Color & Chemicals MFG. Co., Ltd.
    Inventors: Yasuharu NOISHIKI, Takanori SANNAN, Yasuyuki ISONO, Shinzo KANAO, Hiroshi ITOH, Yoshihiko IIJIMA
  • Publication number: 20140112982
    Abstract: The present invention relates to a chewable soft capsule shell and a chewable soft capsule, and to a filled jelly sweet and a process for preparing a chewable soft capsule shell or filled jelly sweet, wherein the chewable soft capsule shell comprises gelatin 10%-50%, water retention agent 10%-40%, thickening agent 2%-20%, water 6%-20%, and said soft capsule shell has a thickness of 0.3-1.2 mm.
    Type: Application
    Filed: August 7, 2012
    Publication date: April 24, 2014
    Applicants: Hangzhou Yangshengtang Healthcare Products Co., Ltd., Natural Medicine Institute of Zhejiang Yangshengtang Co., Ltd., Hainan Yangshegtang Pharmaceutical Co., Ltd.
    Inventors: Cuifeng Cao, Xuesi Zhu, Weiwei Wang
  • Patent number: 8703182
    Abstract: An object of the present invention is to provide a small-sized light-stabilized soft capsule formulation, which has a shell that ensures effective light shielding of an active ingredient encapsulated thereby. The present invention provides a light-stabilized soft capsule formulation comprising a shell containing a non-water-soluble light-shielding agent and having an average thickness of 200 ?m or less, and a medicament encapsulated by the shell.
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: April 22, 2014
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Akihiko Mizutani, Hisakazu Katsuki, Kenichi Sakai
  • Patent number: 8696568
    Abstract: Methods for evaluating and treating patients for dysphagia are provided. In a general embodiment, the method comprises screening the patient for dysphagia symptoms, diagnosing and categorizing the dysphagia if the patient exceeds a threshold of dysphagia symptoms, choosing the proper dysphagia treatment product based the patient's dysphagia, and giving the patient preparation instructions for the dysphagia treatment product.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: April 15, 2014
    Assignee: Nestec S.A.
    Inventors: Michael Rueben Jedwab, Zamzam Kabiry Roughead, Kala Marie Kaspar, Armando Sanchez, Christoph Hartmann, Chrystel Loret, Nathalie Martin, Jan Engmann
  • Patent number: 8685456
    Abstract: The present invention is directed to topical compositions, comprising isoflavone nanoparticle compositions. The isoflavone nanoparticle compositions contain isoflavone in the form of nanoparticles and preferably a carrier. In the topical compositions recrystallization of the isoflavone to bigger particles is avoided.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: April 1, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Raphael Beumer, Chyi-Cheng Chen, Heinz Gutzwiller, Philippe Emmanuel Maillan, Markus Nowotny, Bernd Schlegel, Juergen H. Vollhardt
  • Publication number: 20140072625
    Abstract: Gastric resistant film-forming compositions are described herein. The composition comprises a gastric resistant natural polymer, a film-forming natural polymer, and optionally a gelling agent. Suitable gastric resistant natural polymers include polysaccharides such as pectin and pectin-like polymers. The film-forming composition can be used to prepare soft or hard shell gelatin capsules which can encapsulate a liquid or semi-solid fill material or a solid tablet (Softlet®) comprising an active agent and one or more pharmaceutically acceptable excipients. Alternatively, the composition can be administered as a liquid with an active agent dissolved or dispersed in the composition. The compositions are not only gastric resistant but may also prevent gastric reflux associated with odor causing liquids, such as fish oil or garlic oil, encapsulated in a unit dosage form and esophageal irritation due to the reflux of irritant drugs delivered orally.
    Type: Application
    Filed: November 12, 2013
    Publication date: March 13, 2014
    Applicant: Banner Pharmacaps Inc.
    Inventor: Nachiappan Chidambaram
  • Publication number: 20140056982
    Abstract: Improved compositions for tissue augmentation are provided. These compositions comprise an amount of crosslinked material sufficient to provide a melt temperature (Tm) greater than 37 C, wherein microparticles can be substantially uniformly dispersed and maintained at ambient room temperature as well as body temperature. Said compositions also provide high shear moduli, sufficient to effectively deliver microparticles into dense tissue and narrow intersticial spaces without significant disruption to the homogeneous distribution of microparticles within the solution. The provided compositions can be stored and shipped at room temperature without significant detriment to the material composition. Additional embodiments include a system for delivery of tissue augmentation materials and methods of manufacture thereof.
    Type: Application
    Filed: November 1, 2013
    Publication date: February 27, 2014
    Inventor: Russell J. Anderson
  • Publication number: 20130292292
    Abstract: A kit and method for compounding medicated treats for pet animals includes a first compound, a second compound, a mold assembly, and a blister pack subkit. The first compound includes an edible binding agent for the medicated treat. The second compound includes a nutritional supplement. The first compound and the second compound are admixed together with an auxiliary ingredient, which admixture is formed into the medicated treats using the mold assembly. The mold assembly includes at least a mold plate, a base plate, and a pair of mold clamps. The kit may also include an extractor to facilitate removal of medicated treats from the mold assembly. The blister pack subkit includes a blister pack for receiving the medicated treats, and an adhesive backing for sealing the medicated treats within the blister pack.
    Type: Application
    Filed: March 14, 2013
    Publication date: November 7, 2013
    Applicant: MEDISCA PHARMACEUTIQUE INC.
    Inventors: Antonio Dos Santos, Panagiota Danopoulos
  • Publication number: 20130287820
    Abstract: Compositions for an oral delivery vehicle are described as well as methods for their manufacture and administration. The oral delivery vehicles can be made in any size or shape and can further comprise a medicament or other substance or object to be orally delivered. The vehicle can, for example, take the form of a pouch or capsule. Alternatively, a medicament or other substance to be orally delivered can be coated with the composition. In another alternative, the medicament or other substance to be orally delivered can be dispersed within a matrix of the composition. The compositions for the oral delivery vehicle are also suitable for use as an animal food or treat or use as a hunting bait or lure.
    Type: Application
    Filed: March 19, 2013
    Publication date: October 31, 2013
    Inventor: FOODSOURCE LURES CORPORATION
  • Publication number: 20130280304
    Abstract: The present invention provides an improved method of administering a medicinal, dental or nutritional agent to a non-human animal, such as a domesticated dog or cat. The method comprises mixing a liquid composition in a mixer at various speeds and pressures for a period of time; pouring the liquid composition onto a conveyor belt propelled by polymer rollers, wherein the polymer rollers allow the components to advance on the conveyor belt without adhering to the belt; evenly distributing the composition on the belt with the use of a knife; heating the composition in one or more hot-air chambers; obtaining a film comprised of the composition; cutting the film into strips; and then administering one or more of the strips to the non-human animal by placing the strip under the tongue of the animal, i.e., by sub-lingual administration.
    Type: Application
    Filed: October 22, 2012
    Publication date: October 24, 2013
    Inventor: Douglas Kramer
  • Publication number: 20130266664
    Abstract: Electrospun scaffolds crosslinked with acrylates and methods of making the same are provided. Because the cross-linking linking is carried out under mild conditions, biologically active agents are incorporated into the scaffolds in a facile manner.
    Type: Application
    Filed: December 20, 2011
    Publication date: October 10, 2013
    Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Hu Yang, Gary L. Bowlin, Alpana Dongargaonkar
  • Publication number: 20130259910
    Abstract: A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand alone secondary scaffold implant or unit for treatment of tissue defects.
    Type: Application
    Filed: May 20, 2013
    Publication date: October 3, 2013
    Applicant: HISTOGENICS CORPORATION
    Inventors: Sonya Shortkroff, Laurence J. B. Tarrant, Eric J. Roos, Robert Lane Smith, Hans P. I. Claesson
  • Publication number: 20130253074
    Abstract: Disclosed herein is a hyaluronic acid epoxide derivative film comprises a polymer containing a hydroxyl (—OH) terminal group. The film is prepared by allowing an epoxy crosslinker to react with a mixture of hyaluronic acid and a polymer containing a hydroxyl (—OH) terminal group and has improved physical strength, in vivo stability, flexibility, adhesiveness to biological tissue, and biocompatibility.
    Type: Application
    Filed: March 22, 2013
    Publication date: September 26, 2013
    Applicant: GENEWEL CO., LTD
    Inventors: Young Woo Lee, Wan Jin Cho, Ji Yeon Jang
  • Publication number: 20130224300
    Abstract: The present invention provides therapeutic compositions including a therapeutic agent in a non-aqueous matrix having an absorption enhancer and therapeutic agent, as well as methods for administering such compositions and providing enhanced oral bioavailability.
    Type: Application
    Filed: August 24, 2012
    Publication date: August 29, 2013
    Inventor: Edward T. Maggio
  • Publication number: 20130216623
    Abstract: Drug formulations, devices and methods are provided to deliver biologically active substances to the eye. The formulations are delivered into scleral tissues adjacent to or into the suprachoroidal space without damage to the underlying choroid. One class of formulations is provided wherein the formulation is localized in the suprachoroidal space near the region into which it is administered. Another class of formulations is provided wherein the formulation can migrate to another region of the suprachoroidal space, thus allowing an injection in the anterior region of the eye in order to treat the posterior region.
    Type: Application
    Filed: March 15, 2013
    Publication date: August 22, 2013
    Applicant: ISCIENCE INTERVENTIONAL CORPORATION
    Inventor: ISCIENCE INTERVENTIONAL CORPORATION
  • Publication number: 20130206639
    Abstract: A method of making a gelled composition that includes combining water and an effervescent tablet in a vessel, the effervescent tablet including at least 200 mg gelatin and an effervescent couple that includes an acid and a base, heating an aqueous composition (e.g., in a microwave oven), optionally adding cold water to the heated composition, and chilling the composition for a period sufficient for the composition to form a gel.
    Type: Application
    Filed: March 15, 2013
    Publication date: August 15, 2013
    Applicant: AMERILAB TECHNOLOGIES, INC.
    Inventor: AMERILAB TECHNOLOGIES, INC.
  • Publication number: 20130195769
    Abstract: The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.
    Type: Application
    Filed: March 11, 2013
    Publication date: August 1, 2013
    Applicant: FOAMIX LTD.
    Inventor: Foamix Ltd.
  • Publication number: 20130189304
    Abstract: This invention provides methods and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents at temperatures near the phase transition temperature of the membranes.
    Type: Application
    Filed: December 18, 2012
    Publication date: July 25, 2013
    Applicant: MEDIMMUNE, LLC
    Inventor: MEDIMMUNE, LLC
  • Publication number: 20130136792
    Abstract: A multi phase soft gelatin dosage form comprising at least one preformed solid dosage form and at least one liquid fill phase. The multi phase soft gelatin dosage forms of the present invention are especially useful to combine at least one solid dosage form and at least one liquid phase for single ingestion. Method and apparatus for manufacturing the multiphase soft gelatin dosage forms are also described. The solid phase, liquid phase or coatings may comprise active pharmaceutical ingredients, nutraceuticals, nutritional supplements, therapeutic substances, functional excipients or combinations thereof.
    Type: Application
    Filed: June 3, 2011
    Publication date: May 30, 2013
    Applicant: ACCUCAPS INDUSTRIES LIMITED
    Inventors: Peter Draper, James Edward Draper, Beth Marie Okutan
  • Publication number: 20130136775
    Abstract: A method for manufacturing a drug-delivery composition includes providing at least a pharmaceutically active composition, providing a hydrophobic matrix; and mixing the hydrophobic matrix and the pharmaceutically active composition to form a paste-like or semi-solid drug-delivery composition.
    Type: Application
    Filed: November 30, 2011
    Publication date: May 30, 2013
    Inventors: Andreas Voigt, Jörg Kriwanek, Scott Hampton, Andreas Reiff, Sonja Ludwig