Gelatin Or Derivative Patents (Class 514/774)
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Publication number: 20080114078Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types.Type: ApplicationFiled: June 28, 2007Publication date: May 15, 2008Applicant: FUJIFILM MANUFACTURING EUROPE B.V.Inventors: Jan Bastiaan BOUWSTRA, Andries Johannes Jozef VAN ES, Yuzo TODA
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Patent number: 7309502Abstract: The present invention relates to a pharmaceutical composition and the method for the preparation thereof. The composition comprises 1.5˜6.9% (w/v) of one or more substances selected from sodium chloride, sodium bicarbonate, potassium chloride, magnesium sulfate, calcium chloride, calcium gluconate, and the like, and 3˜18% (w/v) of one or more substances selected from hydroxyethylstarch, dextran, carboxymethylstarch, polyvinyl-pyrrolidone, gelatin derivatives, and the like as well as the remainder of conventional injections, as long as sodium chloride is not less than 1.5% (w/v). The pharmaceutical composition of the present invention is used to treat and save the wounded and patients, as well as to treat shock, its advantages include safe and convention use, rapid and good curative effect, long time maintenance, extensive uses and the like.Type: GrantFiled: August 5, 2005Date of Patent: December 18, 2007Inventor: Chaoying Zhao
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Patent number: 7118761Abstract: Wound care devices having a topically applied silver-based antimicrobial finish are provided. The finish comprises at least one silver ion-containing compound and at least one binder compound. The finish may be applied to a target substrate, such as a fiber, fabric, film, foam, hydrogel, or hydrocolloid to provide a single layer antimicrobial wound care device. Alternatively, a silver-containing layer may be combined with one or more additional layers of target substrate to provide a composite antimicrobial wound care device. The device may also contain an odor-absorbing component capable of reducing or eliminating odors that are inherently associated with infectious wounds. Also provided is a method for making the wound care device and a composition of matter comprising the silver-based antimicrobial finish.Type: GrantFiled: August 14, 2003Date of Patent: October 10, 2006Inventors: T. Andrew Canada, Robert L. Schuette, Raymond C. Sturm, Kenneth M. Wiencek, Jason L. Kreider
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Patent number: 7063837Abstract: The present invention discloses a method and composition for the treatment of bacterial infections by the parenteral introduction of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for that bacteria and an appropriate carrier for delivering the lytic enzyme into a patient. The injection can be done intramuscularly, subcutaneously, or intravenously.Type: GrantFiled: July 19, 2001Date of Patent: June 20, 2006Assignees: New Horizons Diagnostics Corp, Rockefeller UniversityInventors: Vincent Fischetti, Lawrence Loomis
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Patent number: 6974594Abstract: Methods for preparing products containing moisture-sensitive materials, including biological materials such as proteins, peptides or live cells, comprising at least the steps: (i) providing a coating liquid comprising at least one active, a sugar polymer and a water soluble/miscible solvent; (ii) providing a quantity of microparticles comprising at least water soluble gel forming solid particles; (iii) fluidizing said quantity of microparticles within a processing chamber of a of a suitable apparatus to form a fluidized bed of said microparticles; (iv) spraying said coating liquid onto said fluidized bed from beneath the fluidized bed to coat said microparticles therewith under saturated moisture conditions; and (vi) allowing coated microparticles to dry, are described. Also described are compositions and uses.Type: GrantFiled: January 25, 2002Date of Patent: December 13, 2005Assignee: Gainful Plan LimitedInventors: Thomas S. Y. Ko, Terence P. Y. Au Yeung
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Patent number: 6914051Abstract: A penetrating antibiotic gel for treating pain, inflammation and other pathological conditions affecting musculoskeletal tissues and other soft tissues of the body. The composition includes an antibiotic compound and a mobilizing agent in an amount sufficient to enable the antimicrobial compound to penetrate into the sub-dermal soft tissues. The antimicrobial compound may be a macrolide antibiotic compound such as azithromycin, erythromycin or roxithromycin, for example, and the mobilizing agent may be an organogel compound, such as pluronic lecithin liposomal organogel (PLO). The composition may further include a penetration enhancing adjuvant, such as d-limonene, for example. The composition may be applied topically so as to penetrate into the sub-dermal soft tissues, or may injected so as to be absorbed into the soft tissues locally.Type: GrantFiled: June 28, 2001Date of Patent: July 5, 2005Inventor: David M Allen
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Patent number: 6878389Abstract: Disclosed is both a method and composition for controlling deleterious organisms, such as insects, nematodes and weeds by applying a compound comprised of a liquid medium comprising an azide and an azide stabilizer. The azide can be selected from the group consisting of sodium azide and potassium azide or a combination of the two. The composition provides an effective pesticide, without causing significant harm to the environment. The composition may be applied to soil to control a population of a deleterious organism.Type: GrantFiled: October 9, 2001Date of Patent: April 12, 2005Assignee: Auburn UniversityInventor: Rodrigo Rodriguez-Kabana
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Patent number: 6855334Abstract: Controlled release of active agents from sustained release push delivery devices having high drug loading are described wherein residual drug content in the device is minimized by the utilization of a flow-promoting layer between a semi-permeable wall and drug layer comprising the device.Type: GrantFiled: November 27, 2001Date of Patent: February 15, 2005Assignee: Alta CorporationInventors: Padmanabh Bhatt, Evangeline Cruz, Noymi Yam
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Patent number: 6797260Abstract: A composition is disclosed which has been shown to stop or control bleeding and seal open small blood vessels while accelerating the healing process of abraded oral “gum” and other “skin” (epithelial) tissues. The composition is preferably in the form of a paste which promotes ease of application and use of the composition. A variety of instruments can be used in application and cleanup of the composition showing versatile unparalleled friendly usage. The composition preferably comprises aluminum chloride, ferric sulfate (subsulfate), regenerated oxidized cellulose, aluminum ammonium sulfate, absorbable gelatin and a solvent. The composition has many dental and medical procedure applications.Type: GrantFiled: September 18, 2003Date of Patent: September 28, 2004Inventor: Terence Prevendar
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Patent number: 6790453Abstract: Encapsulation compositions in which an encapsulate (A) is encapsulated in a matrix (B) may be prepared by: (i) mixing matrix (B) with a liquid plasticizer and encapsulate (A) in an extruder, to obtain a melted mixture of encapsulate (A) and matrix (B); and (ii) extruding the melted mixture, to obtain an extruded mixture.Type: GrantFiled: March 14, 2002Date of Patent: September 14, 2004Assignee: McCormick & Company, Inc.Inventors: Michael A. Porzio, Dmitriy Zasypkin
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Patent number: 6703011Abstract: Described is a fragrance control release system which is an emulsifier-free, single phase, nonporous, continuous, permeable polymeric film having a substantially uniform thickness of from about 1 up to about 150 microns, having entrapped and dissolved therein molecules of at least one fragrance substance capable of evolving from said film into the environment proximate said film by means of molecular diffusion at a permeation rate of from about 1×10−7 up to about 0.1 mg-mm/cm2-min in a sustained and controlled release manner. Also described is a process for using the aforementioned system for imparting a fragrance into the environment above the unobstructed outer surface of the aforementioned polymer film which is coated on the surface of a solid or semi-solid support, e.g., a woven or non-woven fabric substrate; or a solid surface or human epidermis.Type: GrantFiled: June 27, 2001Date of Patent: March 9, 2004Assignee: International Flavors & Fragrances Inc.Inventors: Adi Shefer, Shmuel David Shefer, Michael John Robert White
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Patent number: 6667059Abstract: A coating for masking or reducing the detectable presence of certain characteristic odor or odors, taste or tastes of pharmaceutical preparations, particularly Valerian extracts, is described. The coating comprises from one to three coating compartments, in any combination or as a single-layer amalgam. The first coating compartment comprises a hydroxyalkyl cellulose and an anti-tackiness agent. The second coating compartment may comprise a sugar and at least one anti-tackiness agent. The third coating compartment may comprise a methacrylate copolymer, a hydroxyalkyl cellulose and an anti-tackiness agent.Type: GrantFiled: May 30, 2001Date of Patent: December 23, 2003Assignee: Ancile Pharmaceuticals, Inc.Inventors: I-Lan T. Sue, Pou-Hsiung Wang, Lori McDonald Smith
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Patent number: 6652840Abstract: A composition is disclosed which has been shown to stop or control bleeding and seal open small blood vessels while accelerating the healing process of abraded oral “gum” and other “skin” (epithelial) tissues. The composition is preferably in the form of a paste which promotes ease of application and use of the composition. A variety of instruments can be used in application and cleanup of the composition showing versatile unparalleled friendly usage. The composition preferably comprises aluminum chloride, ferric sulfate (subsulfate), regenerated oxidized cellulose, aluminum ammonium sulfate, absorbable gelatin and a solvent. The composition has many dental and medical procedure applications.Type: GrantFiled: February 8, 2002Date of Patent: November 25, 2003Inventor: Terence Prevendar
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Patent number: 6627224Abstract: Compositions containing a low dose of entecavir are administered on a daily basis to treat hepatitis B virus infection and/or co-infections. Formulations for the oral administration of a low dose of entecavir are provided. Other pharmaceutically active substances can be included in the entecavir composition or can be separately administered for the treatment of hepatitis B virus infection or for the treatment of co-infected patients.Type: GrantFiled: February 23, 2001Date of Patent: September 30, 2003Assignee: Bristol-Myers Squibb Co.Inventors: Richard J. Colonno, Omar L. Sprockel, Abizer Harianawala, Divyakant Desai, Michael G. Fakes
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Patent number: 6620432Abstract: A pharmaceutical composition is provided containing an admixture of phenytoin sodium and an erodible matrix which extends the release of the phenytoin sodium over about a two hour period. The erodible matrix comprises binder(s) and diluent(s) which control the release of drug from the pharmaceutical composition. The erodible matrix can further comprise an alkaline pH modifier.Type: GrantFiled: May 11, 2001Date of Patent: September 16, 2003Assignee: Mylan Pharmaceuticals Inc.Inventors: William J. Addicks, Joseph P. Duda, Daniel A. Snider, Kerry R. Benson
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Patent number: 6569454Abstract: The present invention comprises a method of tablet preparation. The invention provides a simple and cost effective method to compress good tablets.Type: GrantFiled: February 27, 2001Date of Patent: May 27, 2003Inventor: Minh Van Nguyen
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Patent number: 6491946Abstract: The invention relates to a pharmaceutical preparation comprising levothyroxine sodium, potassium iodide, microcrystalline cellulose and binding agent, which is free of antioxidants or further auxiliaries, and processes for its production.Type: GrantFiled: January 5, 2001Date of Patent: December 10, 2002Assignee: Merck Patent GesellschaftInventors: Sven Schreder, Marion Nischwitz
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Patent number: 6485746Abstract: Controlled-release formulations providing a “pulsed” plasma profile of a sedative-hypnotic compound having a particularly short half-life are provided. The formulation contains a sedative-hypnotic compound or precursor thereof that is metabolized to generate a sedative-hypnotic compound in vivo, wherein the compound has a mean plasma half life ranging from 0.1 to 2 hours; and at least one release retardant such that, following administration of the formulation to a patient, the patient has specified pulsed plasma profile for the sedative-hypnotic compound as disclosed herein. In a preferred embodiment, the sedative-hypnotic compound is NBI-34060.Type: GrantFiled: August 28, 2000Date of Patent: November 26, 2002Assignee: Neurocrine Biosciences, Inc.Inventors: D. Bruce Campbell, W. Jay Thiele
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Patent number: 6468959Abstract: There is provided a plural dosage form for peptide pharmaceuticals comprising a matrix of gelatin or gelatin derivative having distributed therein the peptide pharmaceutical in particular insulin, as well as, pharmaceutically conventional carriers and additives. By selection of the appropriate gelatin the pharmaceutical is liberated in the small intestine or the large intestine so that is not enzymatically degraded anymore by peptidases.Type: GrantFiled: April 5, 1994Date of Patent: October 22, 2002Assignee: ALFATEC-Pharm GmbHInventors: Jens-Christian Wunderlich, Ursula Schick, Jurgen Freidenreich, Jurgen Werry
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Patent number: 6465010Abstract: The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applications. One embodiment is a tablet intended for oral administration. The tablet comprises at least one active ingredient and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered or heated, excellent tablet binding characteristics are obtained. The tablet is intended primarily for oral administration and dissolves in the presence of water. Also disclosed is a process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water.Type: GrantFiled: July 12, 2001Date of Patent: October 15, 2002Assignee: Drugtech CorporationInventors: Yury Lagoviyer, R. Saul Levinson, Denis Stotler, Thomas C. Riley
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Patent number: 6419956Abstract: A coating for masking or reducing the detectable presence of certain characteristic odor or odors, taste or tastes of pharmaceutical preparations, particularly Valerian extracts, is described. The coating comprises from one to three coating compartments, in any combination or as a single-layer amalgam. The first coating compartment comprises a hydroxyalkyl cellulose and an anti-tackiness agent The second coating compartment may comprise a sugar and at least one anti-tackiness agent. The third coating compartment may comprise a methacrylate copolymer, a hydroxyalkyl cellulose and an anti-tackiness agent.Type: GrantFiled: December 30, 1999Date of Patent: July 16, 2002Assignee: Ancile PharmaceuticalsInventors: I-Lan T. Sue, Pou-Hsiung Wang
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Patent number: 6413713Abstract: A method for preserving blood platelets is described. The method uses 1%-3% gelatin in the platelet preservation medium, and storing the platelets in the preservation medium at temperatures below 0° C. and at least 70 atmospheres pressure for at least one day.Type: GrantFiled: October 30, 1998Date of Patent: July 2, 2002Assignee: HyperBaric SystemsInventor: Vladimir L. Serebrennikov
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Patent number: 6413541Abstract: Method for producing intrabuccally disintegrating tablets, which comprises the following Steps (a), (b) and (c), wherein a medicament is mixed before granulation or tabletting: (a) a step of dissolving at least one saccharide having a high solubility in water and at least one water-soluble binder in water alone or in water and an alcohol; (b) a step of mixing the solution obtained in above Step (a) with at least one excipient, granulating, drying, and tabletting the mixture under a low compression pressure; (c) a step of aging the tablets obtained in Step (b), and intrabuccally disintegrating tablets produced by the above method are provided. The method of the present invention is a simple method for producing intrabuccally disintegrating tablets in large scale without using specific facility, and by which intrabuccally disintegrating tablets showing good disintegrating property in oral cavity as well as having sufficient strength can be obtained.Type: GrantFiled: July 11, 2000Date of Patent: July 2, 2002Assignee: Dainippon Pharmaceutical Co., Ltd.Inventors: Yoshimi Shirai, Kiyomi Sogo, Kazuyoshi Ogasawara, Yutaka Higashi, Yasuhiko Nakamura
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Patent number: 6387391Abstract: This invention provides a claycy and sticky substance as a new biomaterial that cannot be found in the current medical field, which is bioresorbable, shows tackiness, plasticity and shape holding ability at a temperature of approximately from 30 to 40° C. and can give unrestricted shapes at body temperature or more by increasing its fluidity. This clayey and sticky substance comprises a copolymer of two or more bioresorbable monomers, preferably any one of copolymers of p-dioxanone with D-lactic acid, L-lactic acid, D,L-lactic acid, trimethylene carbonate and &egr;-caprolactone, or a mixture of two or more of these copolymers. This clayey and sticky or clayey substance is suited for a hemostatic material, an adhesive material for tissues, a prosthetic material for tissue reconstruction use, a carrier of drug delivery system, a plugging material, an accretion-preventing material and a scaffold material for tissue engineering use.Type: GrantFiled: April 16, 1999Date of Patent: May 14, 2002Assignee: Takiron Co., Ltd.Inventors: Yasuo Shikinami, Hiroyuki Kawarada, Chika Nishi
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Patent number: 6368626Abstract: Controlled release of active agents from sustained release push delivery devices having high drug loading are described wherein residual drug content in the device is minimized by the utilization of a flow-promoting layer between a semi-permeable wall and drug layer comprising the device.Type: GrantFiled: November 1, 1999Date of Patent: April 9, 2002Assignee: ALZA CorporationInventors: Padmanabh Bhatt, Evangeline Cruz, Noymi Yam
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Patent number: 6352974Abstract: The present invention relates to novel compositions, in particular to compositions comprising calcitonin or a fragment or conjugate thereof and to methods for preparing such compositions. It also relates to oral formulations comprising the compositions and to shelf stable formulations of calcitonin or a fragment or conjugate thereof.Type: GrantFiled: September 21, 1999Date of Patent: March 5, 2002Assignee: Eurand International S.p.A.Inventors: Matteo Ghirri, Marco Zema
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Patent number: 6350469Abstract: The present invention relates to a novel pharmaceutical composition and process for preparing swallowable methylcellulose tablets that disintegrate rapidly and meet USP standards in 0.1N hydrochloric acid as well as water.Type: GrantFiled: February 14, 2000Date of Patent: February 26, 2002Assignee: SmithKline Beecham CorporationInventors: Bruce Daggy, Naresh I Mehta, Priyashri Nayak
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Patent number: 6346515Abstract: A collagen matrix comprises collagen fibrils which are cross-linked to one another by reducing sugar or a reducing sugar derivative. The collagen matrix may be formed into a membrane useful in guided tissue regeneration.Type: GrantFiled: June 18, 1999Date of Patent: February 12, 2002Assignee: Colbar R & D Ltd.Inventors: Sanhu Pitaru, Matityahu Noff
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Patent number: 6315994Abstract: A cell culture medium and hydrogel matrix for long term storage and proliferation of cells is provided. The cell culture medium and hydrogel matrix include an effective amount of polar amino acids, the polar amino acids selected from the group consisting of arginine, lysine, histidine, glutamic acid, and aspartic acid. The cell culture medium comprises about 5 to about 150 mM of polar amino acids. The hydrogel matrix comprises about 3 to about 150 mM of polar amino acids. Arginine and glutamic acid are preferably supplemented in the cell culture medium. Arginine, lysine, and glutamic acid are preferably supplemented in the hydrogel matrix. A method of maintaining viability and functioning of a transplant is also provided. The method of maintaining viability of a transplant includes encapsulating the cells in a hydrogel matrix and injecting the encapsulated cells into the host organism.Type: GrantFiled: January 11, 2001Date of Patent: November 13, 2001Inventors: Anton-Lewis Usala, Richard Chris Klann
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Patent number: 6284270Abstract: The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applications. One embodiment is a tablet intended for oral administration. The tablet comprises at least one active ingredient and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered or heated, excellent tablet binding characteristics are obtained. The tablet is intended primarily for oral administration and dissolves in the presence of water. Also disclosed is a process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water.Type: GrantFiled: August 4, 1999Date of Patent: September 4, 2001Assignee: Drugtech CorporationInventors: Yury Lagoviyer, R. Saul Levinson, Denis Stotler, Thomas C. Riley
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Patent number: 6277394Abstract: The current invention is a biomedical implant comprising a biomedical matrix material and a biodegradable porosifying agent. As the porosifying agent degrades in situ, an implant with an inter-connecting network is formed. The resultant mechanically stable implant allows for tissue and fluid influx into the matrix. The invention is also directed to a method for repair of mammalian tissue using the above-described implant.Type: GrantFiled: June 16, 2000Date of Patent: August 21, 2001Assignee: Cohesion Technologies, Inc.Inventor: David H. Sierra
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Patent number: 6274168Abstract: A pharmaceutical composition is provided containing an admixture of phenytoin sodium and an erodible matrix which extends the release of the phenytoin sodium over about a two hour period. The erodible matrix comprises binder(s) and diluent(s) which control the release of drug from the pharmaceutical composition. The erodible matrix can further comprise an alkaline pH modifier.Type: GrantFiled: February 23, 1999Date of Patent: August 14, 2001Assignee: Mylan Pharmaceuticals Inc.Inventors: William J Addicks, Joseph P Duda, Daniel A. Snider, Kerry R Benson
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Patent number: 6274570Abstract: A liquid pesticidal composition, which is substantially free of water, comprising a hydrophobic pesticide or mixture of pesticides dissolved in an organic solvent and comprising as surfactants (a) a castor oil ethoxylate having 30-50 mol ethoxylate, (b) a branched C8-C18 alcohol ethoxylate having 5-10 mol ethoxylate, and (c) a tristyrenephenol-ethoxylate having 8-30 mol ethoxylate, or its phosphate or salt thereof. The compositions also include gels having a viscosity of 500 to 20,000 mPas and comprising additionally a gelling agent.Type: GrantFiled: December 22, 1998Date of Patent: August 14, 2001Assignee: Syngenta Crop Protection, Inc.Inventors: Manfred Vogt, William Baettig
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Patent number: 6245350Abstract: A process for encapsulation of caplets in a capsule comprises the following steps: a. providing empty capsule parts; b. filling at least one of said capsule parts with one or more caplets; c. putting said capsule parts together; and d. treating the combined parts by cold shrinking. The solid dosage forms obtainable by such a process are tamper-proof in that they cannot be opened in a way to be reassembled without showing such opening process.Type: GrantFiled: April 5, 1996Date of Patent: June 12, 2001Assignee: Warner-Lambert CompanyInventors: James Amey, Dominique Cade, Paul Maes, Robert Scott
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Patent number: 6231881Abstract: A cell culture medium and hydrogel matrix for long term storage and proliferation of cells is provided. The cell culture medium and hydrogel matrix include an effective amount of polar amino acids, the polar amino acids selected from the group consisting of arginine, lysine, histidine, glutamic acid, and aspartic acid. The cell culture medium comprises about 5 to about 150 mM of polar amino acids. The hydrogel matrix comprises about 3 to about 150 mM of polar amino acids. Arginine and glutamic acid are preferably supplemented in the cell culture medium. Arginine, lysine, and glutamic acid are preferably supplemented in the hydrogel matrix. A method of maintaining viability and functioning of a transplant is also provided. The method of maintaining viability of a transplant includes encapsulating the cells in a hydrogel matrix and injecting the encapsulated cells into the host organism.Type: GrantFiled: July 10, 1998Date of Patent: May 15, 2001Inventors: Anton-Lewis Usala, Richard Chris Klann
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Patent number: 6224905Abstract: A method for preparing solid rapidly disintegrating dosage forms shaped as biconvex tablets having symmetrical top and bottom surfaces and dosage forms obtainable thereby.Type: GrantFiled: December 3, 1998Date of Patent: May 1, 2001Assignee: Janssen Pharmaceutica N.V.Inventors: Janice Lawrence, Gary Posage
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Patent number: 6221393Abstract: The present invention relates to a delayed-release pharmaceutical composition which is in the form of tablets prepared by direct tableting and consisting of at least one active principle and a matrix which gives the said composition its delayed-release effect, characterized in that the said matrix consists at least in part of pregranulated polysaccharides of high molecular weight and of synthetic or natural origin.Type: GrantFiled: October 22, 1999Date of Patent: April 24, 2001Assignee: Rhodia ChimieInventors: Jean-Pierre Collaueri, Guillaume Conrath, Paul-Joël Derian, Gabriel Gousset, Frédéric Mauger
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Patent number: 6193986Abstract: An oily composition having excellent storability and forming no precipitate of an ingredient selected from the group of gelatin and gum arabic during the storage for a long period of time is provided. This composition is composed of a solid phase comprising an effective substance selected from the group consisting of a water-soluble substance and water-dispersible substance and 50 to 4,000 parts by weight, for 100 parts by weight of the effective substance, of the ingredient, and an oil phase comprising an oily component and an emulsifier, wherein the solid phase in the form of fine particles having an average particle diameter of not larger than 5 &mgr;m is dispersed in the oil phase, the water content of the solid phase is not higher than 30% by weight and the water content of the whole composition is not higher than 20% by weight.Type: GrantFiled: February 24, 1998Date of Patent: February 27, 2001Assignee: The Nisshin Oil Mills, Ltd.Inventor: Satoshi Sakurada
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Patent number: 6149941Abstract: The invention relates to a process for improving the taste of solid formulations containing one or more active ingredients.Type: GrantFiled: October 30, 1998Date of Patent: November 21, 2000Assignee: Merck Patent Gesellschaft mitInventors: Eugen Schwarz, Gernot Moschl, Siva Tallavajhala
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Patent number: 6110484Abstract: The current invention is a biomedical implant comprising a biomedical matrix material and a biodegradable porosifying agent. As the porosifying agent degrades in situ, an implant with an inter-connecting network is formed. The resultant mechanically stable implant allows for tissue and fluid influx into the matrix. The invention is also directed to a method for repair of mammalian tissue using the above-described implant.Type: GrantFiled: November 24, 1998Date of Patent: August 29, 2000Assignee: Cohesion Technologies, Inc.Inventor: David H. Sierra
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Patent number: 6103269Abstract: The invention relates to accurately meterable shaped articles, for example granules or pellets, containing hydrophilic macromolecules, active compounds and optionally further pharmaceutically acceptable structure-forming substances and auxiliaries, the active compound being present in a matrix in dissolved, suspended or emulsified form, and a novel process for the production of these shaped articles, the process being particularly economically and ecologically acceptable, and use of the shaped articles as medicaments, in which the bioavailability, shelf life and tolerability is increased. Using the shaped articles or mixtures according to the invention, intermediates or final products for pharmacy, cosmetics, diagnosis, analysis or dietetics (healthcare) can additionally be advantageously prepared.Type: GrantFiled: March 1, 1999Date of Patent: August 15, 2000Assignee: Alfatec-Pharma GmbHInventors: Jens-Christian Wunderlich, Ursula Schick, Jurgen Werry, Jurgen Freidenreich
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Patent number: 6080426Abstract: A process for encapsulation of caplets in a capsule comprises the following steps: a. providing empty capsule parts; b. filling at least one of said capsule parts with one or more caplets; c. putting said capsule parts together; and d. treating the combined parts by cold shrinking. The solid dosage forms obtainable by such aprocess are tamper-proof in that they cannot be opened in a way to be reassembled without showing such opening process.Type: GrantFiled: January 11, 1996Date of Patent: June 27, 2000Assignee: Warner-Lamberg CompanyInventors: James Amey, Dominique Cade, Paul Maes, Robert Scott
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Patent number: 6066337Abstract: A particulate support matrix, and a dosage form made therefrom, and processes for making such support matrices and dosage forms, which disintegrate or dissolve in a matter of just a few seconds once placed into an aqueous environment. First, a porous particulate powder matrix which will serve as the dosage form matrix is produced. In a second step, the pharmaceutical, for example an antihistamine, decongestant, or antibiotic is combined with the powder. Other additives may also be added to the mixture. In a third step the mixture is formed into a dosage form. Finally, in a fourth step, a coating may be formed upon the outer surface of the dosage form to enhance the intactness and durability of the dosage form.Type: GrantFiled: July 6, 1998Date of Patent: May 23, 2000Assignee: The Board of Regents of the University of Oklahoma and Janssen Pharmaceutica, Inc.Inventors: Loyd V. Allen, Bingnan Wang, John Desmond Davies
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Patent number: 6060078Abstract: The present invention relates to a chewable tablet containing a medicament in a core and a process for preparation thereof. In particular, the present invention relates to a chewable tablet comprising a core containing a medicament in the center of the tablet in a state of jelly or chewable base and an outer layer wrapping the core which is made up of chewable base such as a gum, a soft candy or a caramel. The chewable tablet is easy to take and has a good taste and nice chewing property due to the unique tablet form. In addition, the tablet has an advantage in bioavailability resulting from increased absorption rate and excellent stability due to unique preparation process. Therefore, the chewable tablet and the preparation process of the present invention can be used in pharmaceutical industry usefully.Type: GrantFiled: September 28, 1998Date of Patent: May 9, 2000Assignee: Sae Han Pharm Co., Ltd.Inventor: Young Won Lee
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Patent number: 6011016Abstract: The present invention relates to a stable, tasteless fat soluble vitamin emulsion composition which can be sprayed on foodstuffs at room temperature, particularly ready-to-eat breakfast cereal, for the purpose of vitamin fortification of said foodstuffs.Type: GrantFiled: October 23, 1997Date of Patent: January 4, 2000Assignee: BASF CorporationInventors: Douglass N. Schmidt, Melissa Mack
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Patent number: 5968540Abstract: Hydrodynamic baits for the control of orthopterous insects are disclosed which contain an attractant, a humectant and a gel former. The baits are designed to function in harsh and/or dynamic microclimates such as for example commercial kitchens or outdoor environments subject to typical circadian influences such as temperature and moisture. A further advantage of the disclosed baits is their lack of attractiveness to mammals.Type: GrantFiled: June 30, 1997Date of Patent: October 19, 1999Assignee: The United States of America, as represented by the Secretary of AgricultureInventors: Richard J. Brenner, Kevin Burns
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Patent number: 5968546Abstract: The present invention relates to the treatment of skin defect by organotypically cultured autologous keratinocytes isolated from the outer root sheath of hair follicles. Methods for primary as well as subsequent organotypic cultures (epidermal equivalents) in fully defined media eventually supplemented by autologous human serum and substances isolated from blood components, with minimal allogeneic biological supplements, are disclosed. Techniques to prepare epidermal equivalents for transplantation are included, as well as a method for the transport of the epidermal equivalents.Type: GrantFiled: May 15, 1998Date of Patent: October 19, 1999Inventors: Marcus Baur, Thomas Hunziker, Alain Limat, Wolfram Riedel, Christian Toloczyki
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Patent number: 5955438Abstract: A collagen matrix comprise collagen fibrils which are cross-linked to one another by a reducing sugar or a reducing sugar derivative. The collagen matrix may be formed into a membrane useful in guided tissue regeneration.Type: GrantFiled: July 19, 1995Date of Patent: September 21, 1999Assignee: ColBar R & D Ltd.Inventors: Sandu Pitaru, Matityahu Noff
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Patent number: 5948429Abstract: A biopolymer solution is polymerized to form a gel which is freeze-dried and crosslinked with ultraviolet radiation to form a biopolymer foam. The foam is filled with a collagen solution and the combination is freeze-dried or the foam is filled with a collagen solution containing extracellular matrix particulates and that combination is freeze-dried, thereby forming a foam to which extracellular matrix particulates are attached.Type: GrantFiled: May 16, 1997Date of Patent: September 7, 1999Assignee: Tissue Engineering, Inc.Inventors: Eugene Bell, Timothy W. Fofonoff
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Patent number: 5902606Abstract: Sparingly water-soluble active compounds, for example medicinal substances, are converted into the dissolved (molecularly disperse) state by dissolving them in a hydrophilic peptide having a molecular weight above 100 D, for example gelatin. The solubility both during storage and during use of the formulation by the user or patient is thereby ensured, without organic solvents or solubilizing agents which cause undesirable side effects being required.Type: GrantFiled: March 17, 1995Date of Patent: May 11, 1999Assignee: Alfatec-Pharma GmbHInventors: Jens-Christian Wunderlich, Ursula Schick, Jurgen Werry, Jurgen Freidenreich