Starch Or Derivative Patents (Class 514/778)
  • Patent number: 9597292
    Abstract: Improved oral dosage forms of methyl hydrogen fumarate and prodrugs thereof are disclosed. Methods of treating diseases such as multiple sclerosis and psoriasis using such dosage forms are also disclosed.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: March 21, 2017
    Assignee: XenoPort, Inc.
    Inventors: Sami Karaborni, Sarina Grace Harris Ma, Chen Mao, Ching Wah Chong, Peter Robert Prinz Freed, Mesut Ciper, Stefanie Krenzlin, David J. Wustrow, Peter A. Virsik
  • Patent number: 9358207
    Abstract: There is provided granules for the production of flash-melt pharmaceutical oral dosage forms. In addition to one or more medicaments, the granules are composed of an excipient combination consisting of a superdisintegrant, a dispersing agent, a distributing agent, and a binder and may also include other conventional ingredients such as sweetening and flavoring agents. The subject granules are advantageous in that they are stable and can be prepared without the aid of solvents and without the need for special environments or handling. Dosage forms, especially tablets, prepared therefrom on conventional equipment disintegrate in the mouth in under about twenty five seconds.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: June 7, 2016
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Sanjeev H. Kothari, Divyakant S. Desai
  • Patent number: 9243279
    Abstract: A latent effervescent body comprising a selective agent is disclosed. A method of using the latent effervescent body in a method to selectively enrich a target microorganism is also disclosed. The method comprises providing a sample, a culture medium, and the latent effervescent body. The method further comprises contacting the sample, the culture medium, and the latent effervescent body under conditions to facilitate growth of the target microorganism. The method further comprises releasing the selective agent from the latent effervescent body. Optionally, the method includes detecting a microorganism.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: January 26, 2016
    Assignee: 3M Innovative Properties Company
    Inventors: Wensheng Xia, Patrick A. Mach, Joseph M. Beaurline, Jason W. Bjork, Jie J. Liu
  • Publication number: 20150141525
    Abstract: A method for producing starch granules suitable as an excipient for an orally disintegrating tablet. Fluidized bed granulation is performed by spraying a starch paste in small amounts while a ?-starch is being fluidized using an air-fluidized bed. Subsequently, fluidized bed drying is performed at a temperature equal to or higher than the gelatinization temperature of the ?-starch. This yields starch granules having a high degree of gelatinization in comparison with the amount of ?-starch adhered to the ?-starch by the spraying of the starch paste. These starch granules alone impart satisfactory oral disintegratability and breaking strength to the tablet. Accordingly, when used as an excipient during tableting of orally disintegrating tablets, other auxiliary excipients such as saccharides or crystalline cellulose need not be added.
    Type: Application
    Filed: April 23, 2013
    Publication date: May 21, 2015
    Applicant: JAPAN CORN STARCH CO., LTD.
    Inventors: Masao Umezaki, Hiroshige Murase, Toshio Uno, Toshiyuki Niwa
  • Patent number: 9029427
    Abstract: Disclosed is a solid preparation which comprises at least one active ingredient and at least one dissolution-controlling base substance and can be formed by compression molding, wherein the dissolution-controlling base substance contains 5.0 to 99.9% by weight (inclusive) of a modified starch having a moisture retaining capacity of 400% or more and a gel indentation load of 200 g or more, containing a water-soluble ingredient in an amount of 40 to 95% by weight, having particles passing through a 75 ?m-mesh sieve in the proportion of 90% by weight or more and particles passing through a 32 ?m-mesh sieve in the proportion of 20% by weight or more, and having an average particle diameter of not smaller than 20 ?m and smaller than 50 ?m.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: May 12, 2015
    Assignee: Asahi Kasei Chemicals Corporation
    Inventors: Masaaki Endo, Kazuhiro Obae, Ichirou Ibuki, Yoshihito Yaginuma
  • Publication number: 20150125498
    Abstract: The present invention relates to a particle stabilized emulsion or foam comprising at least two phases and solid particles, wherein said solid particles are starch granules and said starch granules or a portion thereof are situated at the interface between the two phases providing the particle stabilized emulsion or foam. The invention further relates to the use of said particle stabilized emulsion or foam for encapsulation of substances chosen from biopharmaceuticals, proteins, probiotics, living cells, enzymes and antibodies, sensitive food ingredients, vitamins, and lipids in food products, cosmetic products, skin creams, and pharmaceutical formulations.
    Type: Application
    Filed: December 15, 2011
    Publication date: May 7, 2015
    Applicant: SPEXIMO AB
    Inventor: Johan Timgren
  • Patent number: 9023333
    Abstract: The invention relates to the use of a shaped article containing at least one skeleton-forming agent, proteins being excepted, optionally one or more active substances and also optionally one or more auxiliary substances for the purpose of external application, to a process for producing the stated shaped articles, and also to novel shaped articles.
    Type: Grant
    Filed: September 30, 2003
    Date of Patent: May 5, 2015
    Inventors: Stefan Frahling, Ralf Malessa
  • Publication number: 20150119471
    Abstract: The invention discloses a technical process to prepare a self-reinforced starch composite used to produce capsules. This composite is made by uniformly mixing the matrix phase and the particulate reinforced phase at a proper proportion, the former being one or a combination of the starches selected from the group consisting of oxidized starch, cationic starch and esterified starch; and the latter, cross-linked starch or starch nanocrystals. This composite is processed into the forms of granules, films, or sheets by extrusion method and these different forms of the composite can be used to replace the gelatin as the raw material of capsules because its barrier property, processability, and mechanical properties are significantly improved.
    Type: Application
    Filed: October 21, 2014
    Publication date: April 30, 2015
    Inventors: Fangwen Shuai, Nuozi Zhang, Xiangfeng Wang, Jiawei Zhang
  • Publication number: 20150119473
    Abstract: The invention discloses a method for preparing starch-based softgel capsules, which, specifically, includes the following 2 steps: 1, Extrude the starch-based premixed material into starch-based extrusion film, 2, Apply the gel solution coating to the extrusion film to form composite starch film, 3) Process two composite starch films into starch-based softgel capsules by rotary die process.
    Type: Application
    Filed: October 23, 2014
    Publication date: April 30, 2015
    Inventors: Fangwen Shuai, Nuozi Zhang, Xiangfeng Wang, Jiawei Zhang
  • Publication number: 20150119472
    Abstract: The invention discloses an extrusion method for preparing starch-based softgel capsules, which, specifically, includes the following 2 steps: 1, co-extruding the starch premix and gel solution to form composite starch film. 2, processing two composite starch films into starch-based softgel capsules by rotary die process.
    Type: Application
    Filed: October 22, 2014
    Publication date: April 30, 2015
    Inventors: Fangwen Shuai, Nuozi Zhang, Xiangfeng Wang, Jiawei Zhang
  • Publication number: 20150119470
    Abstract: The invention discloses a method for preparing starch softgel capsules, which, specifically, involves in the following three steps: 1, Extruding starch premix and gel solution into films respectively; 2, Forming composite starch film through co-extrusion method; 3, Processing the composite starch film into starch softgel capsules.
    Type: Application
    Filed: October 21, 2014
    Publication date: April 30, 2015
    Inventors: Fangwen Shuai, Nuozi Zhang, Xiangfeng Wang, Jiawei Zhang
  • Publication number: 20150098909
    Abstract: A soluble fiber lozenge provided herein includes a body that is partially or wholly receivable in an oral cavity. The body includes a soluble-fiber matrix and one or more additives dispersed in the soluble-fiber matrix. In some cases, a soluble fiber lozenge provided herein includes at least 40 weight percent of soluble fiber. In some cases, soluble fiber in soluble fiber lozenge provided herein can include maltodextrin. The soluble fiber lozenge is adapted to release one or more additives from the body when the body is received within the oral cavity of a consumer and exposed to saliva. A method of making soluble fiber lozenges provided herein includes forming a molten mixture of at least 40 weight percent soluble fiber, one or more additives, and less than 15 weight percent water while maintaining a mixture temperature of less than 200° C. and portioning the molten mixture into a plurality of soluble fiber lozenges. In some cases, the ingredients can be mixed to form the molten mixture in an extruder.
    Type: Application
    Filed: October 3, 2014
    Publication date: April 9, 2015
    Inventors: Feng Gao, Diane L. Gee, Shuzhong Zhuang, Phillip M. Hulan, William J. Burke, Gerd Kobal
  • Patent number: 8974821
    Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: March 10, 2015
    Assignee: Durect Corporation
    Inventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton, Roger Fu, Michael S. Zamloot
  • Patent number: 8962036
    Abstract: Disintegrable preparations of lanthanum carbonate prepared by co-precipitation, facilitating the manufacture of oral pharmaceutical dosage forms such as tablets, capsules, powders, granules, and sprinkles, and the use of such dosage forms to treat subjects with hyperphosphatemia are disclosed.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: February 24, 2015
    Assignee: Mylan Pharmaceuticals Inc.
    Inventors: Andrea Blum Works, John Twist, Okey Noe
  • Publication number: 20150050355
    Abstract: A particulate SAE-CD composition is provided. The SAE-CD composition has an advantageous combination of physical properties not found in known solid forms of SAECD. In particular, the SAE-CD composition possesses an advantageous physicochemical and morphological property profile such that it can be tailored to particular uses. The SAE-CD composition of the invention has improved flow and dissolution performance as compared to known compositions of SAE-CD.
    Type: Application
    Filed: September 17, 2014
    Publication date: February 19, 2015
    Inventors: James D. Pipkin, Gerold L. Mosher, Douglas B. Hecker
  • Publication number: 20150050334
    Abstract: The present invention relates to new acid resistant hard pharmaceutical capsules, a process for their manufacture and use of such capsules particularly but not exclusively for oral administration of pharmaceuticals, veterinary products, food and dietary supplements to humans or animals. The capsules of the invention are obtained by aqueous compositions comprising a water soluble film forming polymer and gellan gum in a mutual weight ratio of 4 to 15 weight parts of gellan gum for 100 weight parts of film forming polymer.
    Type: Application
    Filed: August 27, 2014
    Publication date: February 19, 2015
    Inventors: Dominique Nicolas Cade, Xiongwei David He
  • Publication number: 20150045454
    Abstract: Methods are provided according to aspects of the present invention for making starch fiber or particle compositions by wet-electrospinning or wet-electrospraying including providing a solution or dispersion of starch in an aqueous or non-aqueous solvent or dispersant, where the starch is present at a concentration above the critical entanglement concentration, with the proviso that the aqueous or non-aqueous solvent or dispersant does not consist only of water; heating the solution or dispersion of starch to a temperature above the crystallization temperature of the starch; electro spinning or electro spraying the heated solution or dispersion of starch to produce starch fibers or starch particles, respectively; and contacting the starch fibers or starch particles with a coagulation bath fluid.
    Type: Application
    Filed: February 27, 2013
    Publication date: February 12, 2015
    Applicant: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Lingyan Kong, Gregory R. Ziegler
  • Publication number: 20150045452
    Abstract: The present application provides an orally-disintegrating tablet having excellent tablet hardness and disintegrability. The present application further provides a method of producing a disintegrative particulate composition including three components consisting of a first disintegrator component of an acid-type carboxymethylcellulose, a second disintegrator component and an excipient. The method includes a first wet granulation step using any two of the three components, and a second wet granulation step using granules obtained in the first wet granulation step and the remaining one component of the three components not used in the first wet granulation step. The production method may further includes a crystalline cellulose as a fourth component or a third step of mixing a crystalline cellulose into granules obtained in the second wet granulation step. Disintegrative particulate compositions obtained by these methods are also disclosed.
    Type: Application
    Filed: March 27, 2013
    Publication date: February 12, 2015
    Inventors: Takahiro Hiramura, Kiyoshi Ikura, Sae Itaya, Tomohito Okabayashi, Naohiro Hashikawa, Tetsuro Morita, Kimko Ikeda, Haruka Wakayama
  • Patent number: 8951556
    Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: February 10, 2015
    Assignee: Durect Corporation
    Inventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton, Roger Fu, Michael S. Zamloot
  • Patent number: 8945614
    Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: February 3, 2015
    Assignee: Durect Corporation
    Inventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton, Roger Fu, Michael S. Zamloot
  • Publication number: 20150025158
    Abstract: The application relates to a composition comprising from about 10% (w/w) to about 40% (w/w) pregelatinized waxy potato starch, pregelatinized waxy cassava starch, or any mixture thereof; from about 10% (w/w) to about 20% (w/w) gum; and from about 40% (w/w) to about 70% (w/w) dispersant.
    Type: Application
    Filed: July 22, 2013
    Publication date: January 22, 2015
    Applicant: CORN PRODUCTS DEVELOPMENT, INC.
    Inventors: Robert A. Skorge, Bernard C. Sekula, Sean Maloney, Paul Staniszewski
  • Publication number: 20150018434
    Abstract: Crushed pills containing medicines and/or supplements for animals are mixed with an edible paste formulated from all naturally occurring ingredients including specific starches that when mixed together bind the composition to the crushed pills. The mixture is designed to stick to animal fur as well as been very palatable to animal. The medicine is delivered to the animal by offering the paste from a spoon or finger or by smearing the paste on the animal, where it readily adheres to the fur and may be licked off. To encourage finicky animals such as cats to accept the composition from a spoon or finger, and to make it a pleasurable experience for them, the composition includes a desirable food such as real salmon or real meat.
    Type: Application
    Filed: February 26, 2013
    Publication date: January 15, 2015
    Inventor: Barbara Cappelli
  • Patent number: 8912237
    Abstract: The present invention relates to novel compositions containing finely dispersed carotenoids. The novel compositions of this invention can be used as colorants or additives for food, beverages, animal feeds, cosmetics or drugs. The colorant composition may be a liquid or a solid composition. The solid composition comprises at least one carotenoid which is dispersed in a matrix, wherein the matrix contains at least one carbohydrate and/or one modified carbohydrate and optionally, a protein, a modified protein or mixtures thereof, wherein the at least one carbohydrate and/or one modified carbohydrate is starch or modified starch, wherein the amount of starch or modified starch is from about 10 wt-% to 60 wt-% of based on the total weight of the matrix, and wherein the concentration of the at least one carotenoid is at least 2% based on the total weight of the composition. Preferably ?-carotene is used as a solid water-dispersible colorant composition.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: December 16, 2014
    Assignee: DSM IP Assets B.V.
    Inventor: Karl Manfred Voelker
  • Publication number: 20140364514
    Abstract: The present invention is directed to a co-attrited stabilizer composition comprising: a) microcrystalline cellulose in an amount of from 20%-90% by weight of the composition; b) a hydrocolloid in an amount of from 5%-50% by weight of the composition, wherein the hydrocolloid is selected from at least one member of the group consisting of carboxymethyl cellulose having a degree of substitution of at least 0.95, pectin, alginate, carrageenan, xanthan gum, agar gum, wellan gum, or gellan gum; and c) a starch in an amount of from 5%-50% by weight of the composition, wherein the stabilizer composition has a gel strength (G?) of at least 25 Pa when measured after 24 hours in a 2.6% solids water dispersion at 20° C. The composition is useful as a stabilizer, particularly in food and beverage products.
    Type: Application
    Filed: November 30, 2012
    Publication date: December 11, 2014
    Applicant: FMC CORPORATION
    Inventors: Zheng Tan, Michael Sestrick, Nadia Yaranossian, Jeremy Ondov
  • Publication number: 20140335034
    Abstract: A consumer product comprises silane-modified oil comprising a hydrocarbon chain selected from the group consisting of: a saturated oil, an unsaturated oil, and mixtures thereof; and at least one hydrolysable silyl group covalently bonded to the hydrocarbon chain. The consumer product further comprises a preservative.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Rajan Keshav PANANDIKER, Beth Ann SCHUBERT, John August WOS, Luke Andrew ZANNONI, Nathan Ray Whitely
  • Publication number: 20140335033
    Abstract: A consumer product comprises silane-modified oil comprising a hydrocarbon chain selected from the group consisting of: a saturated oil, an unsaturated oil, and mixtures thereof; and at least one hydrolysable silyl group covalently bonded to the hydrocarbon chain. The consumer product further comprises a perfume.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Rajan Keshav PANANDIKER, Beth Ann SCHUBERT, John August WOS, Luke Andrew ZANNONI, Nathan Ray Whitely
  • Publication number: 20140335032
    Abstract: A consumer product comprises silane-modified oil comprising a hydrocarbon chain selected from the group consisting of: a saturated oil, an unsaturated oil, and mixtures thereof; and at least one hydrolysable silyl group covalently bonded to the hydrocarbon chain. The consumer product further comprises a hydroxyl functional organic species and is substantially free of silica particles.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Rajan Keshav PANANDIKER, Beth Ann SCHUBERT, John August WOS, Luke Andrew ZANNONI, Nathan Ray Whitely
  • Publication number: 20140335035
    Abstract: A consumer product comprises silane-modified oil comprising a hydrocarbon chain selected from the group consisting of: a saturated oil, an unsaturated oil, and mixtures thereof; and at least one hydrolysable silyl group covalently bonded to the hydrocarbon chain. The consumer product further comprises a particulate benefit agent.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Rajan Keshav PANANDIKER, Beth Ann SCHUBERT, John August WOS, Luke Andrew ZANNONI, Nathan Ray WHITELY, Sherrie Ann JORDAN
  • Patent number: 8883221
    Abstract: Micronutrient combination product, wherein the micronutrient combination product comprises zeaxanthin, lutein, zinc and copper.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: November 11, 2014
    Assignee: Bausch & Lomb Incorporated
    Inventors: Guenter Bellmann, Gudrun Claus-Herz
  • Patent number: 8865778
    Abstract: A controlled release excipient composition suitable in formulation of a slow or extended release tablet, contains a synergistic mixture of substantially uncross-linked carboxymethyl starch, or sodium starch glycolate (SSG), and a hydrophilic, non-ionic cellulose ether, preferably hydroxypropylmethylcellulose. Whether or not a SSG in the mixture is sufficiently uncross-linked in the context of the invention can be determined by sedimentation: 0.25 g of the formulation in 100 ml deionized water after 24 hours at 25° C., if subjected to centrifugation at 6080 G at 25° C. for 15 minutes, should exhibit a sedimentation volume of more than 60 ml.
    Type: Grant
    Filed: December 4, 2007
    Date of Patent: October 21, 2014
    Assignee: Campina Nederland Holding B.V.
    Inventors: Linqiu Cao, John Richard Langridge, Alexander Wilhelmus Van Gessel
  • Publication number: 20140308327
    Abstract: An insecticidal feeding bead comprises: a food source comprising a swellable starch; an insecticide active; and greater than or equal to 60 weight percent water, wherein weight percent is based upon a total weight of the insecticidal feeding bead. A method of making an insecticidal feeding system comprises: forming an insecticidal feeding bead, comprising: a food source comprising a swellable starch; an insecticide active; and greater than or equal to 60 weight percent water, wherein weight percent is based upon a total weight of the insecticidal feeding bead; absorbing the insecticide active in the swellable starch; and absorbing the swellable starch in the water.
    Type: Application
    Filed: April 10, 2013
    Publication date: October 16, 2014
    Applicant: Henkel Consumer Goods Inc.
    Inventors: Debra A. Park, Joan M. Bergstrom, Arlana M. Brugato
  • Publication number: 20140294948
    Abstract: The invention relates in one aspect to a composition, specifically a jelly, the use of which composition as an auxiliary means is to ease the taking of oral medication in solid form, which composition comprises iota-carrageenan as a jellifying agent and citric acid as a salivating agent, characterized in that the composition further comprises maltodextrin. In another aspect, the composition comprises a calcium sequestrant for adjusting Ca-ion activity of the composition. In one embodiment, the composition comprises iota-carrageenan in 0.7-1.0% in mass, citric acid in 0.06-0.07% in mass, maltodextrin in 1.5% in mass, all relative to the total mass of the composition, and an amount of a calcium sequestrant such that the Ca-ion activity of the composition is between 20 ppm and 80 ppm.
    Type: Application
    Filed: April 2, 2014
    Publication date: October 2, 2014
    Applicant: PAXTREE LTD
    Inventor: Ron BRUIJNS
  • Publication number: 20140276378
    Abstract: Provided herein is a microstructure array comprising a plurality of dissolving microstructures such as microprojections attached to a base. The plurality of microstructures comprise an active agent in a biocompatible and water-soluble matrix, where the water-soluble matrix preferably comprises a polysaccharide polymer and a sugar alcohol, and the base typically comprises a non-water soluble matrix. The plurality of microstructures, upon penetration of the subject's skin, undergo dissolution to deliver the active agent. Also provided are related microstructure formulations, in dried and liquid form, methods for preparing the above-described microstructure arrays, and methods for administering an active agent by application of a microstructure array as provided herein to a subject's skin, among other features.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 18, 2014
    Applicant: Corium International, Inc.
    Inventors: Guohua Chen, Zhongli Ding, Esi Ghartey-Tagoe, Parminder Singh
  • Publication number: 20140271521
    Abstract: A process for forming a personal care article, the process including (a) producing an extrudate from a twin screw extruder, and (b) forming the extrudate into the personal care article. The personal care article includes (i) from about 10% to about 60% of one or more anionic surfactants, wherein the one or more anionic surfactants have a Krafft point of less than 30° C.; (ii) from about 10% to about 50% of one or more water soluble polymers; (iii) from about 1% to about 30% of one or more plasticizers; and (iv) from about 10% to about 50% water.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Robert Wayne GLENN, JR., Todd Ryan THOMPSON, Ungyeong JUNG, Changwei ZHU, Alireza TABATABAEI-NAEINI
  • Patent number: 8828270
    Abstract: The invention relates to a safely handleable and transportable composition including an alpha-cyclodextrin-chlorine dioxide complex and an inert substance, and also a method for production thereof.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: September 9, 2014
    Assignee: Wacker Chemie AG
    Inventors: Benno Krueger, Gerald Fleischmann, Stefan Neumann
  • Patent number: 8821936
    Abstract: This invention provides a solid pharmaceutical formulation having high physical strength and further having excellent drug release properties and digestibility of excipients when administered, which comprises (a) an active medical ingredient and (b) a pre-gelatinized starch in an amount of 10 to 90% by weight, said pre-gelatinized starch being prepared by pre-gelatinizing a cheap and stable usual starch during the procedure for formulation. This invention also provides a method for preparing the solid pharmaceutical formulation.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: September 2, 2014
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventor: Tadashi Mukai
  • Patent number: 8771649
    Abstract: This invention relates to inducible release vehicle comprised of crosslinked carbohydrates or proteins and an active ingredient. The release is induced by an external stimulus, e.g. an enzyme such as amylase. Such a vehicle can particularly be used in applications for preventing microbial decay or combating microbial infections. Other uses are for oral applications such as providing antdaries or flavoring compounds and for pharmaceutical and/or nutraceutical applications.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: July 8, 2014
    Assignee: Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek TNO
    Inventors: Henricus Matheus Wilhelmus Maria Thijssen, Roy Christiaan Montijn, Johannes Wilhelmus Timmermans, Theodoor Maximiliaan Slaghek, Jacobus Johannes Frederick van Veen, Johannes Wilhelmus Leonardus Boumans
  • Patent number: 8771650
    Abstract: This invention relates to inducible release vehicle comprised of crosslinked carbohydrates or proteins and an active ingredient. The release is induced by an external stimulus, e.g. an enzyme such as amylase. Such a vehicle can particularly be used in an applications for preventing microbial decay or combating microbial infections. Other uses are for oral applications such as providing anti-caries or flavoring compounds and for pharmaceutical and/or nutraceutical applications.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: July 8, 2014
    Assignee: Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek TNO
    Inventors: Henricus Matheus Wilhelmus Maria Thijssen, Roy Christiaan Montijn, Johannes Wilhelmus Timmermans, Theodoor Maximiliaan Slaghek, Jacobus Johannes Frederik van Veen, Johannes Wilhelmus Leonardus Boumans
  • Patent number: 8771659
    Abstract: The present disclosure relates to novel cosmetic compositions comprising, in a cosmetically acceptable aqueous medium: from 0.1% to 2% by weight of at least one starch, and from 0.1% to 1% by weight, relative to the total weight of the composition, of at least one diester of a carboxylic acid comprising 8 to 30 carbon atoms and of polyethylene glycol. The cosmetic compositions provides a fondant texture, and these compositions rinse out easily. Hair treated with this composition has a soft feel, free of residue. These compositions are may be used for washing and/or conditioning keratin materials such as the hair or the skin.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: July 8, 2014
    Assignee: L'Oreal
    Inventors: Véronique Mahe, Jean-Michel Sturla
  • Publication number: 20140155498
    Abstract: A diagnostic or therapeutic formulation of stable liquid coagulation factors comprises at least one coagulation factor, at least one stabilizer, and optional additives. The stabilizer is either amylopectin, galatomannan polysaccharide, agarose, agaropectin, and gelatin, or a blend of amylopectin, galatomannan polysaccharide, agarose, agaropectin, and gelatin. A preferred additive is the zwitterionic buffer 3-[N-tris(hydroxymethyl)methylamino)-2-hydroxypropane sulfonic acid (TAPSO). The stable liquid coagulation factors can be used as reagents and controls in plasma clotting assays. In addition the therapeutic formulation can be used for factor replacement therapy. The stable liquid clotting factors are made by combining the coagulation factor(s), stabilizer(s), and additive(s) in a liquid carrier and sterilizing the mixture. Coagulation factors can be concentrated by selective precipitation from plasma.
    Type: Application
    Filed: February 7, 2014
    Publication date: June 5, 2014
    Inventor: Leon Wortham
  • Publication number: 20140148515
    Abstract: A system for alleviating the appearance of scar tissue, said system comprising a combination of two compounds; a first compound having properties that perform skin regeneration; and a second compound having properties that provide a physical barrier adapted to protect scar tissue by insulating it from ambient air while maintaining and protecting said first compound that is combined therewith.
    Type: Application
    Filed: November 29, 2012
    Publication date: May 29, 2014
    Inventors: Rene Gauthier, Claude Marquis
  • Patent number: 8715703
    Abstract: Disclosed is a method for the preparation of cosmetic compositions having the texture of a cream. Said preparation is made at the time when the composition is used and includes bringing into contact with each other (A) a liquid phase, (B) a powder containing a gelling agent for the liquid phase (A), and (C) an active cosmetic ingredient, whereby the elements are brought into contact by adding phase (A) to phase (B), subjecting a solid powder containing phase (B) and phase (A) in an immobilized form to mechanical stress to release phase (A). Further disclosed are compositions comprising phase (B) and phase (A) in an immobilized form (which are transformed into a cream when applied to the skin).
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: May 6, 2014
    Assignee: Sensient Cosmetic Technologies
    Inventors: Martine Seu-Salerno, Laurence Fillardet, Virginie Boulier
  • Patent number: 8715731
    Abstract: A process for reducing the intensity of the intrinsic bitter taste of a water soluble active which comprises dry mixing of said active with ?-cyclodextrin.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: May 6, 2014
    Assignee: ISP Investments Inc.
    Inventors: Rama Haldar, Dipan Ray, Deborah Tobia, Donald Koelmel, Sidney Etienne
  • Publication number: 20140113977
    Abstract: This disclosure relates to cyclodextrin-based drug delivery agents that comprise a cyclodextrin moiety covalently linked to a moiety of a gemini surfactant. Pharmaceutical compositions comprising the drug delivery agent and a therapeutic agent are also disclosed.
    Type: Application
    Filed: May 18, 2012
    Publication date: April 24, 2014
    Applicant: University of Saskatchewan
    Inventors: Ildiko Badea, Ronald Verrall, Peng Yang, Marianna Foldvari, Jackson Chitanda, Deborah Michel
  • Publication number: 20140100292
    Abstract: The present invention relates inter alia to the use of moisture-conditioned disintegrants or expanding agents in tablet manufacture for the selective adjustment of the mechanical properties, the dissolution kinetics (dissolution) and/or the water loading of tablets.
    Type: Application
    Filed: October 8, 2013
    Publication date: April 10, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Eduard BALTHES, Johannes GESER, Peter SCHNEIDER
  • Patent number: 8691750
    Abstract: The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.
    Type: Grant
    Filed: May 8, 2012
    Date of Patent: April 8, 2014
    Assignee: Axolabs GmbH
    Inventors: Rainer Constien, Anke Geick, Philipp Hadwiger, Torsten Haneke, Ludger Markus Ickenstein, Carla Alexandra Hernandez Prata, Andrea Schuster, Timo Weide
  • Publication number: 20140093574
    Abstract: The present invention relates to solid dispersions including, but not limited to, co-processed carbohydrates with different solubilities and concentrations, which have a microcrystalline plate structure. The solid dispersions, excipient systems and formulations of the present invention are highly compactable and durable and when compressed into solid dosage forms demonstrate uniform densification, low friability at low pressures, and and/or relatively constant low disintegration times at various hardnesses. The solid dosage forms of the present invention demonstrate superior organoleptics, disintegration, and/or robustness.
    Type: Application
    Filed: December 5, 2013
    Publication date: April 3, 2014
    Applicant: SPI Pharma, Inc.
    Inventors: John Tillotson, Cecil Propst
  • Patent number: 8685456
    Abstract: The present invention is directed to topical compositions, comprising isoflavone nanoparticle compositions. The isoflavone nanoparticle compositions contain isoflavone in the form of nanoparticles and preferably a carrier. In the topical compositions recrystallization of the isoflavone to bigger particles is avoided.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: April 1, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Raphael Beumer, Chyi-Cheng Chen, Heinz Gutzwiller, Philippe Emmanuel Maillan, Markus Nowotny, Bernd Schlegel, Juergen H. Vollhardt
  • Patent number: 8658692
    Abstract: Disclosed herein are a method for preparation of an inclusion-complex including a physiologically active hydrophobic substance in cyclodextrin and a derivative thereof, and use of the inclusion-complex prepared by the same. More particularly, the present invention provides a method for preparing an inclusion-complex, which includes agitating cyclodextrin and a derivative thereof in an agitator at high speed, spraying a physiologically active hydrophobic substance dissolved in alcohol onto the agitator, and drying and crushing the mixture obtained from the preceding step and, in addition, use of the prepared inclusion-complex. The present inventive method has merits of reduced inclusion time and increased inclusion rate. The prepared inclusion-complex has excellent cell and collagen proliferation effects compared to physiologically active hydrophobic substances which were not inclusion processed, thereby being used in production of a cosmetic composition with improved anti-wrinkle and anti-ageing effects.
    Type: Grant
    Filed: September 3, 2008
    Date of Patent: February 25, 2014
    Assignee: Macrocare Tech., Ltd.
    Inventors: Moo-Sung Kim, Sang-Rin Lee, Yong-Dae Park
  • Publication number: 20140023707
    Abstract: The present invention comprises a co-processed carbohydrate system, and formulations produced therefrom, which formulations are directly compressible into solid dosage forms, some of which rapidly and completely dissolve or disintegrate in the oral cavity within 60 seconds. The invention also comprises the solid dosage forms produced by directly compressing the co-processed carbohydrate system, some of which, when placed in the oral cavity, shall dissolve or disintegrate, preferably within about 60 seconds.
    Type: Application
    Filed: September 27, 2013
    Publication date: January 23, 2014
    Applicant: SPI Pharma, Inc.
    Inventors: Gary T. Norman, Kalyan S. Nuguru, Arun F. Amin, Sarath Chandar