Carbohydrate Or Lignin, Or Derivative Patents (Class 514/777)
  • Patent number: 10653702
    Abstract: The invention relates to the field of metal-organic framework materials and the field of medical technology, relates to a method for inhibiting tumor angiogenesis or preventing and/or treating tumor, comprising administering to a subject in need thereof an effective amount of a metal-organic framework comprising Fe and ligand. The invention further relates to a method for inhibiting the expression of matrix metalloproteinase in a cell, comprising administering to the cell an effective amount of a metal-organic framework comprising Fe and ligand.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: May 19, 2020
    Assignee: Yunnan University
    Inventors: Bin Li, Daomei Chen, Jiaqiang Wang, Minfang Nie
  • Patent number: 10618969
    Abstract: Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: April 14, 2020
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Svetomir N. Markovic, Wendy K. Nevala
  • Patent number: 10602769
    Abstract: A melt spun tobacco composition, e.g., in flake or particle form, for oral use in a mammal made by melt spinning comprising tobacco and/or a tobacco extract and at least one material which is solid at room temperature, which melts at or below 500° F., and carries from 1% to 70% of tobacco when processed through melt spinning, and solidifies again in less than 5 seconds after melt spinning.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: March 31, 2020
    Assignee: PHILIP MORRIS PRODUCTS S.A.
    Inventor: Richard C. Fuisz
  • Patent number: 10561533
    Abstract: The present invention relates to a composition that can be used as or as part of a wound dressing and to wound dressings comprising the same. More specifically, the present invention relates to a composition that disrupts and kills bacteria within a biofilm and also prevents biofilm formation. The composition comprises a first component selected from the group consisting of chitosan, chitin, derivatives of chitosan, derivatives of chitin, and combinations thereof; at least one triprotic acid and at least one solubilising acid.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: February 18, 2020
    Assignee: MEDTRADE PRODUCTS LIMITED
    Inventors: Andrew Hoggarth, Craig Hardy
  • Patent number: 10336966
    Abstract: The present invention relates to a composition having improved or enhanced fidelity and/or longevity of the fragrance profile, comprising fragrance materials in a diamond construction and at least one substantially non-odorous fragrance modulator. The invention also relates to methods of use of the compositions for perfuming suitable substrates, including hard surfaces and body parts, particularly skin and hair.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: July 2, 2019
    Assignee: The Procter & Gamble Company
    Inventors: Lynette Anne Makins Holland, Christelle Marie Sandrine Bonnet, Fabienne Pastor, Jose Maria Velazquez Mendoza, Jonathan Richard Stonehouse, William Eoghan Staite, David Thomas Stanton, Oreste Todini, Stephen Robert Schofield, Sarah Kyakyo Kanyunyuzi Nyakana, Susana Fernandez Prieto, Johan Smets, Jeffrey John Scheibel, Isabelle Guimet
  • Patent number: 10222370
    Abstract: An assay and a method for identifying a prebiotic to treat a subject in need thereof to promote intestinal barrier integrity or to blunt an inflammatory response are provided.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: March 5, 2019
    Assignees: Rush University Medical Center, Purdue Research Foundation
    Inventors: Ali Keshavarzian, Sander de Kivit, Bruce Hamaker
  • Patent number: 10184096
    Abstract: Urea gellants that are suitable for use in liquid compositions. Liquid compositions that include urea gellants. Related processes.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: January 22, 2019
    Assignee: The Procter & Gamble Company
    Inventors: Susana Fernandez-Prieto, Juan Miravet-Celades, Juan-Jose Ojeda-Flores, Johan Smets
  • Patent number: 10137186
    Abstract: Embodiments herein relate to compositions of and methods for live attenuated alphaviruses. In certain embodiments, a live, attenuated virus composition includes, but is not limited to, one or more live, attenuated alphaviruses and compositions to reduce inactivation and/or degradation of the live, attenuated alphavirus. In other embodiments, the live, attenuated virus composition may be a vaccine composition. In yet other compositions, a live, attenuated alphavirus composition may include HEPES buffer. In other embodiments, the HEPES buffer may further include a carbohydrate and gelatin and/or a salt.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: November 27, 2018
    Assignee: Takeda Vaccines, Inc.
    Inventors: Dan T. Stinchcomb, Jill A. Livengood, Laszlo Varga
  • Patent number: 9828444
    Abstract: A poly-[1-4]-D-glucosamine derivative comprising [1-4]-D-glucosamine recurring units and comprising a fluoropolyether chain bound to the nitrogen atom in the C-2 position of at least one of the [1-4]-D-glucosamine recurring units.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: November 28, 2017
    Assignee: SOLVAY SPECIALTY POLYMERS ITALY S.P.A.
    Inventors: Ivan Wlassics, Claudio Adolfo Pietro Tonelli, Giuseppe Marchionni
  • Patent number: 9725707
    Abstract: A protein comprising a polypeptide sequence having at least 70% sequence identity to SEQ ID NO:6, SEQ ID NO:2 or SEQ ID NO:4. The protein has ketose 3-epimerase activity.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: August 8, 2017
    Assignee: TATE & LYLE INGREDIENTS AMERICAS LLC
    Inventors: Ryan David Woodyer, Richard W. Armentrout
  • Patent number: 9717681
    Abstract: Improved formulations containing substituted imidazole derivatives of the general formula 1, formula (I) wherein Y is —CH2— or —CO—, R1 is H, halo or hydroxy, R2 is H or halo, and R3 is H or lower alkyl (e.g. C1 to C4 alkyl, preferably C1 or C2 alkyl), or a pharmaceutically acceptable salt, such as an acid addition salt, e.g. the hydrochloride, of a compound of the general formula (I), are in solid fast-dispersing dosage form suitable for pre-gastric absorption.
    Type: Grant
    Filed: November 3, 2003
    Date of Patent: August 1, 2017
    Assignee: R.P. Scherer Technologies, LLC
    Inventors: Susan Banbury, Päivi Juujärvi, Leon Grother, Walter Lunsmann, Owen Murray, Juha-Matti Savola
  • Patent number: 9624313
    Abstract: The presently disclosed subject matter concerns a microbial biopolymer comprising fucose in its composition. This biopolymer consists of a polysaccharide comprising fucose, which represents at least 10% of its composition. This fucose-containing polysaccharide also contains non-sugar components, namely, acyl group substituents. This disclosed subject matter also concerns the process for the production of the biopolymer, which is obtained cultivation of the bacterium Enterobacter A47 (DSM 23139), using glycerol or glycerol-rich mixtures as carbon sources. The fucose-containing biopolymer of the presently disclosed subject matter may be used in several industrial applications (e.g. pharmaceutical, cosmetics and agro-food industries) and in the treatment of industrial wastes (e.g. oil and metal recovery).
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: April 18, 2017
    Assignee: 73100-Setenta E Tres Mil E Cem, LDA
    Inventors: Maria D'Ascencao Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Maria Filomena Andrade De Freitas, Vitor Manuel Delgado Alves
  • Patent number: 9491963
    Abstract: Disclosed herein are sweetener compositions comprising at least one sweetener and at least one sweetness enhancer chosen from terpenes (such as sesquiterpenes, diterpenes, and triterpenes), flavonoids, amino acids, proteins, polyols, other known natural sweeteners (such as cinnamaldehydes, selligueians, hematoxylins), secodammarane glycosides, and analogues thereof, wherein the at least one sweetness enhancer is present in the composition in an amount at or below the sweetness detection threshold level of the sweetness ehancer, and the at least one sweetener and the at least one sweetness enhancer are different.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: November 15, 2016
    Assignee: The Coca-Cola Company
    Inventors: Indra Prakash, Grant E. DuBois, Josef Klucik, Rafael I. San Miguel, Rudolf Johann Fritsch, Venkata Sai Prakash Chaturvedula
  • Patent number: 9456626
    Abstract: The invention relates to a process for producing highly soluble compositions containing purified steviol glycosides from Stevia rebaudiana Bertoni plant extract, more particularly Rebaudioside D. Obtained highly soluble compositions are useful as non-caloric sweeteners or in combination with sugar or high intensity sweeteners in edible and chewable compositions such as beverages, confectionaries, bakery products, chewing gums and the like.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: October 4, 2016
    Assignee: PureCircle Sdn Bhd
    Inventors: Avetik Markosyan, Siddhartha Purkayastha
  • Patent number: 9408918
    Abstract: A compound comprising: (a) a drug carrier comprising coumarin-labeled-cysteine tethered mesoporous silica nanoparticles (MSNs) loaded with a pharmaceutically active agent, and (b) a fluorescein isothiocyanate-?-cyclodextrin (FITC-?-CD) covalently linked to said cysteine and blocking the release of said pharmaceutically active agent from said nanoparticles, wherein cleavage of said covalent linkage removes said cyclodextrin and releases said pharmaceutically active agent, and said coumarin and said fluorescin form a donor-acceptor pair so that said drug carrier has a first emission wavelength when the covalent linkage is intact and the cyclodextrin said present and a second emission wavelength after cleavage of said covalent linkage to remove said cyclodextrin and release said pharmaceutically active agent.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: August 9, 2016
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Ki-Bum Lee, Jinping Lai, Birju Shah
  • Patent number: 9260299
    Abstract: The present invention relates to a method for functionalizing a solid material surface with self assembling or self aggregating cyclodextrins, said method comprising the steps of: providing an adsorption solution comprising at least one modified cyclodextrins and at least one solvent; and contacting a solid material surface with the adsorption solution.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: February 16, 2016
    Assignee: Aalborg Universitet
    Inventors: Kim Lambertsen Larsen, Ronnie Nielsen, Karen Østergaard Styrbæk
  • Patent number: 9249318
    Abstract: An object of the present invention is to obtain a dispersion in which a water-repellent inorganic powder is dispersed in water. The dispersion can be handled easily because the dispersion medium is water. In the case of using the dispersion for cosmetics, the dispersion can be suitably used when an inorganic powder subjected to a water-repellent treatment is mixed in an aqueous cosmetic. A dispersion in which an inorganic powder subjected to a water-repellent organic surface treatment is uniformly dispersed in water, wherein the contents of a water-repellent inorganic powder, a dispersant, and water is 80% by weight or more based on the total amount of the dispersion.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: February 2, 2016
    Assignee: Sakai Chemical Industry Co., Ltd.
    Inventors: Takuro Ashida, Kunitada Nishida, Jun Iwata
  • Patent number: 9243077
    Abstract: The present invention provides a hyaluronic acid derivative comprising disaccharide units of Formula (I), and a hyaluronic acid derivative/drug conjugate wherein one or more drugs are conjugated to the hyaluronic acid derivative.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: January 26, 2016
    Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Tomoko Yasugi, Yoshihiro Tampo, Kenji Yasugi, Tai Hirakura, Tsuyoshi Shimoboji
  • Patent number: 9241905
    Abstract: A pharmaceutical suspension formulation comprising a dose greater than 100 mg/5 ml Cefixime and pharmaceutically acceptable excipients.
    Type: Grant
    Filed: March 23, 2007
    Date of Patent: January 26, 2016
    Assignee: LUPIN LIMITED
    Inventors: Sanjay Chhagan Wagh, Bharat Raghunath Metkar, Makarand Krishnakumar Avachat, Himadri Sen
  • Patent number: 9233112
    Abstract: A pharmaceutical suspension dosage form comprising greater than 80 mg/ml and not more than 150 mg/ml of Cefixime and pharmaceutically acceptable excipients.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: January 12, 2016
    Assignee: LUPIN LIMITED
    Inventors: Shrenik Annasaheb Kole, Bharat Raghunath Metkar, Makarand Krishnakumar Avachat
  • Patent number: 9044513
    Abstract: A crystallized maltitol powder including a maltitol content greater than 99.5% by weight, characterized by a particle-size distribution by volume, determined by laser granulometry, having less than 20% particles less than 200 ?m in size, less than 6% particles less than 100 ?m in size, less than 2% particles less than 40 ?m in size and a pour value less than or equal to 10 seconds, an aerated density greater than 0.85 g/ml, a compacted density greater than 0.97 g/ml, and a compressibility of less than 17%, and to its use in the pharmaceuticals and above all foods sectors, in particular in the formulation of chocolates or table sweeteners.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: June 2, 2015
    Assignee: ROQUETTE FRERES
    Inventors: Manuel Barata, Yves Le Bot, Elsa Muller née Ostermann, Guillaume Ribadeau-Dumas
  • Publication number: 20150148431
    Abstract: A composition suitable for use in a transdermal delivery patch for administration of a biologically active compound, the composition comprising a phosphate compound of tocopherol and a polymer carrier.
    Type: Application
    Filed: November 21, 2014
    Publication date: May 28, 2015
    Inventors: Jeremy Cottrell, Giacinto Gaetano, Mahmoud El-Tamimy, Nicholas Kennedy, Paul David Gavin
  • Publication number: 20150148355
    Abstract: A silicone gel (“silogel”) composition used to deliver pharmaceutical products transdermally as well as a method for producing the silogel composition, which may contain up to 80% additive ingredients. Preferred embodiments of the invention may include silogel compositions which provide high viscosity/no separation due to API. They are not temperature-sensitive, have no shear stress from the ointment mill/EMP, have no gumming up/stickiness, and no hardening.
    Type: Application
    Filed: November 24, 2014
    Publication date: May 28, 2015
    Inventor: John Olin Trimble
  • Publication number: 20150140133
    Abstract: A system is described for long-term controlled release delivery of a drug or a therapeutic agent. According to the invention, one or more drugs or therapeutic agents contained in microspheres are mixed with a temperature sensitive hydrogel which is then introduced directly to the desired situs of the drug or therapeutic agent. The temperature sensitive hydrogel may also contain a drug or a therapeutic agent, for example, a pain relieving drug, for a short-term controlled release. The temperature sensitive hydrogel is in liquid state at room temperature, but upon injection, shortly becomes gelatinous. This system is particularly suitable for treatment of diseases, disorders, or conditions, for example, tumors, discogenic back pain, or arthritis, warranting localized administration of a drug or a therapeutic agent. In addition, the specification provides a method for production of a drug- or therapeutic agent-containing microspheres.
    Type: Application
    Filed: December 4, 2014
    Publication date: May 21, 2015
    Inventor: Tae-Hong Lim
  • Publication number: 20150141524
    Abstract: The invention relates to a method for the production of a solid bio-product wherein at least 80% of the original indigestible oligosaccharide (raffmose, stachyose and verbascose) content has been degraded into digestible mono- and disaccharides, comprising the following steps: 1) providing a mixture of milled or flaked or otherwise disintegrated biomass, comprising oligosaccharides and optionally polysaccharides and further comprising proteinaceous plant parts, water and one or more enzyme preparations containing ?-galactosidase(s); 2) reacting the mixture resulting from step (1) under continuous mixing and under conditions where the water content in the initial mixture does not exceed 65% by weight, for 0.15-36 hours at a temperature of about 20-65° C.; 3) incubating the reacted mixture from step (2) at a temperature and in a time period which inactivate said ?-galactosidase(s), as well as solid bio-products obtainable by such method.
    Type: Application
    Filed: May 5, 2013
    Publication date: May 21, 2015
    Applicant: Hamlet Protein A/S
    Inventors: Katrine Hvid Ellegard, Karl Kristian Thomsen, Ole Kaae Hansen
  • Patent number: 9029426
    Abstract: The invention relates to a process for producing highly soluble compositions containing purified steviol glycosides from Stevia rebaudiana Bertoni plant extract, more particularly Rebaudioside D. Obtained highly soluble compositions are useful as non-caloric sweeteners or in combination with sugar or high intensity sweeteners in edible and chewable compositions such as beverages, confectionaries, bakery products, chewing gums and the like.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: May 12, 2015
    Assignee: PureCircle Sdn Bhd
    Inventors: Avetik Markosyan, Siddhartha Purkayastha
  • Publication number: 20150126617
    Abstract: The present invention relates to a agave syrup product having a low water content. The agave syrup product retains the physical and palatable properties of untreated agave syrup while having a prolonged shelf-life. It can be advantageously used to sweeten beverages (such as hot beverages) and in the manufacture of pharmaceutical compositions (such as throat lozenges) and/or confectionary.
    Type: Application
    Filed: July 11, 2013
    Publication date: May 7, 2015
    Inventor: John Lawrence Rowe
  • Publication number: 20150126618
    Abstract: A biologic formulation of 20% to 95% by weight of hyaluronic acid is provided such that the hyaluronic acid is the most common ingredient in the formulation. The formulation preferably also includes 0.1% to 1.5% by weight of a preservative, and a pH adjuster configured to provide a pH of less than 5.0 in the formulation. The hyaluronic acid is a combination of two or more different molecular weights of hyaluronic acid. The different molecular weights of hyaluronic acid are preferably cross-linked with glucosamine and ceramides.
    Type: Application
    Filed: November 6, 2014
    Publication date: May 7, 2015
    Inventor: David E. Pollock
  • Publication number: 20150126616
    Abstract: N-methyl-N-acylglucamines are suitable as thickening agents in aqueous surfactant solutions containing one or more anionic surfactants of the group including alkyl ether sulfates and alkyl sulfates, the N-methyl-N-acylglucamines containing at least 60 wt.-% of N-methyl-N-acylglucamines that have a C12-, C14-acyl group or an unsaturated C18-acyl group and at the same time less than 5 wt.-% of N-methyl-N-acylglucamines that contain an acyl group <C12. The surfactant solutions are particularly used in cosmetic compositions.
    Type: Application
    Filed: May 29, 2013
    Publication date: May 7, 2015
    Applicant: Clariant Finance (BVI) Limited
    Inventors: Peter Klug, Carina Mildner
  • Publication number: 20150125415
    Abstract: The invention relates to a composition which contains at least one anionic surfactant, a betaine surfactant, a mixture of N-methyl-N-acylglucamines, the acyl groups of which correspond to those of natural coconut oil and/or palm kernel oil, a glycerol derivative, a solvent and optionally one or more additives. The invention also relates to a method for producing the composition. The invention further relates to the use of the composition for the treatment or care of skin or hair, for example as a shampoo, face cleaner, liquid cleaner or shower gel.
    Type: Application
    Filed: May 29, 2013
    Publication date: May 7, 2015
    Applicant: Clariant Finance (BVI) Limited
    Inventors: Peter Klug, Carina Mildner
  • Patent number: 9023381
    Abstract: Pharmacologically effective amounts of a medication are delivered in pleasant tasting delivery vehicles, including gelatins and candies. Mechanisms for the reduction in surface area of noxious taste-imparting aspects of conventional medicines, and dilutive effects of positive masking elements for such medicines, especially products for inducing children to take medicines, are taught—in combination with processes and products thereby.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: May 5, 2015
    Inventor: Michelle Chow
  • Publication number: 20150118322
    Abstract: The disclosure provides a biomedical composition, including: a hyaluronic acid; a modified histidine; and a polymer or C4-C20 alkane, wherein the modified histidine and the polymer or C4-C20 alkane are grafted to at least one primary hydroxyl group of the hyaluronic acid to allow the hyaluronic acid to form a hyaluronic acid derivative, wherein a graft ratio of the modified histidine is about 1-100%, and a graft ratio of the polymer or C4-C20 alkane is about 0-40%.
    Type: Application
    Filed: October 14, 2014
    Publication date: April 30, 2015
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Ya-Chin LO, Hsiang-Fa LIANG, Ming-Cheng WEI, Maggie J.M. LU, Min-Ying LIN, Chih-Peng LIU, Chun-MIN LIU, Hsiang-Wen TSENG, Tse-Min TENG, Jui-Hsiang CHEN, Yi-Man CHOU, Yi-Ting HSIEH, Chia-Mu TU
  • Publication number: 20150118195
    Abstract: The presently disclosed subject matter provides a scalable and electrostretching approach for generating microfibers exhibiting uniaxial alignment from polymer solutions. Such microfibers can be generated from a variety of natural polymers or synthetic polymers. The hydrogel microfibers can be used for controlled release of bioactive agents. The internal uniaxial alignment exhibited by the presently disclosed fibers provides improved mechanical properties to microfibers, contact guidance cues and induces alignment for cells seeded on or within the microfibers.
    Type: Application
    Filed: April 30, 2013
    Publication date: April 30, 2015
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Hai-Quan Mao, Shuming Zhang, Xi Liu, Brian Patrick Ginn
  • Patent number: 9018236
    Abstract: Described herein are cyclodextrin-stabilized microemulsion systems useful for increasing the solubility, stability, bioavailability, or safety of an active agent for delivery to the skin. The microemulsions may reduce the occurrence of skin irritation or odor upon application.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 28, 2015
    Assignee: Precision Dermatology, Inc.
    Inventors: Mark W. Trumbore, Pinaki Ranjan Majhi, Dinen Divyang Shah
  • Publication number: 20150111834
    Abstract: The disclosure provides a recipe for in-situ gel, formed by dissolving at least one polymer and at least one gel prevention agent in a polar solvent to form a solution and placing the solution in a condition for in-situ forming gels. The disclosure also provides an implant and a drug delivery system formed by the recipe.
    Type: Application
    Filed: September 17, 2014
    Publication date: April 23, 2015
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Felice CHENG, Maggie J.M. LU, Yi-Ju KO, Min-Ying LIN, Shuen-Hsiang CHOU
  • Publication number: 20150110875
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain.
    Type: Application
    Filed: July 10, 2014
    Publication date: April 23, 2015
    Inventors: Charles LINDER, Sarina GRINBERG, Eliahu HELDMAN
  • Publication number: 20150111812
    Abstract: Hydrogels and hybrid hydrogels, methods of making the hydrogels/hybrid hydrogels, and methods of using the hydrogels/hybrid hydrogels. The hydrogels have polysaccharide moieties (e.g., chitosan or hyaluronic acid moieties). The hybrid hydrogels have polysaccharide moieties (e.g., chitosan or hyaluronic acid moieties) and poly(ester amide) moieties. The poly(ester amide) moieties can have one or more arginine moieties. The hydrogels/hybrid hydrogels can be used, for example, in consumer products and as cargo carrier materials (e.g., as therapeutic agent carriers).
    Type: Application
    Filed: May 31, 2013
    Publication date: April 23, 2015
    Inventors: Chih-Chang Chu, DeQun Wu, Mingyu He
  • Patent number: 9012517
    Abstract: Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and optionally including proteins. In one aspect, hyaluronic acid-based compositions described herein include zero-length cross-linked moieties and optionally at least one active agent. The present hyaluronic acid-based compositions have enhanced flow characteristics, hardness, and persistence compared to known hyaluronic acid-based compositions. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: April 21, 2015
    Assignee: Allergan, Inc.
    Inventors: Karina Heredia Guillen, Ahmet Tezel
  • Patent number: 9012520
    Abstract: Disclosed herein are sweetener compositions comprising at least one sweetener and at least one sweetness enhancer chosen from terpenes (such as sesquiterpenes, diterpenes, and triterpenes), flavonoids, amino acids, proteins, polyols, other known natural sweeteners (such as cinnamaldehydes, selligueians, hematoxylins), secodammarane glycosides, and analogs thereof, wherein the at least one sweetness enhancer is present in the composition in an amount at or below the sweetness detection threshold level of the sweetness enhancer, and the at least one sweetener and the at least one sweetness enhancer are different.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: April 21, 2015
    Assignee: The Coca-Cola Company
    Inventors: Indra Prakash, Grant E. DuBois, Josef Klucik, Rafael Ignacio San Miguel, Rudolf Johann Fritsch, Venkata Sai Prakash Chaturvedula
  • Publication number: 20150104516
    Abstract: Cohesive high-dosage strength micronized active ingredients may be dispersed in dry powder formulations for inhalation comprising carrier particles, by use of the apparatus described herein.
    Type: Application
    Filed: September 11, 2014
    Publication date: April 16, 2015
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Claudio CAFIERO, Federico TOSINI
  • Publication number: 20150105478
    Abstract: The invention relates to a composition comprising a polyelectrolyte complex of a polyanion and a polycation, and comprising at least one biocide. A preferred composition comprises lignosulfonate and chitosan, preferably in relative a amount of from 1:2 to 60:1 (w/w). The invention further relates to methods for generating a composition according to the invention, and to uses of a mixture according to the invention for protecting an agricultural plant or plant part against a pathogen.
    Type: Application
    Filed: March 5, 2013
    Publication date: April 16, 2015
    Inventors: Wilhelmus Maria van der Krieken, Wilhelmus Bernardus Albertus Hendrikus Rutten, Christiaan Gerardus Johannes Maria Jans
  • Publication number: 20150099928
    Abstract: In one aspect, the invention provides injectable compositions that comprise a suitable hydrophilic polymer (e.g., a suitable polysaccharide) and water, as well as other optional components. In various embodiments, the composition may be provided in a suitable container, for example, in a pre-loaded syringe. In another aspect, methods of performing medical procedures in a tract of a body are provided. In yet another aspect, the invention provides systems for performing medical procedures in a tract of a body.
    Type: Application
    Filed: October 7, 2014
    Publication date: April 9, 2015
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Paul Smith, Felipe Torres, Samuel Raybin, Mary Jo Timm
  • Patent number: 8999305
    Abstract: The invention relates to a composition comprising (1) at least one polar modified polymer, (2) at least one compound selected from a hyperbranched polyol having at least two hydroxyl groups, a sugar silicone surfactant, and a gelling agent.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: April 7, 2015
    Assignee: L'Oreal
    Inventors: Hy Si Bui, Mohamed Kanji, Anita Chon Tong, Chunhua Li, Susan Halpern, Bruno Thierry Bavouzet
  • Patent number: 9000054
    Abstract: The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: April 7, 2015
    Assignee: Senomyx, Inc.
    Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao Qing Tang, Hanghui Liu
  • Publication number: 20150093440
    Abstract: A method of making aggregate particles suitable for a powder aerosol composition that includes forming a dispersion of nanoparticulate drug and/or excipient in a non-aqueous liquid, and spray-drying the dispersion to generate aggregate particles having a mass median aerodynamic diameter of less than or equal to about 100 microns, and particles generated by such method, and compositions of said particles.
    Type: Application
    Filed: October 13, 2011
    Publication date: April 2, 2015
    Applicant: GLAXO GROUP LIMITED
    Inventors: Michiel M. Van Oort, John N. Hong
  • Publication number: 20150087725
    Abstract: A material is described herein. The material includes a multi-vinylsulfone containing molecule and a multi-nucleophile containing molecule. The material can form a hydrogel from an aqueous solution with dissolved multi-vinylsulfone and a multi-nucleophile. The aqueous solution can undergo gelation with a controllable gelation time to form the hydrogel upon administration to a space in a body. The hydrogel can form in situ with controllable properties, which allow the hydrogel to be used in many biomedical applications. Examples of biomedical applications include, but are not limited to, a volume/filler expander, a storage and delivery mechanism for biologics, and as a tissue interacting surface.
    Type: Application
    Filed: November 29, 2012
    Publication date: March 26, 2015
    Inventors: Ying Chau, Yu Yu
  • Publication number: 20150086631
    Abstract: Chitosan nanoparticles are provided for use in the in vivo treatment of connective tissues in root canal therapies. The nanoparticles are optionally linked with one or more photoactivatable compounds for providing antibactenal/antibiofilm properties, neutralizing bacterial byproducts and/or chemical/photodynamic crosslinking to achieve enhanced mechanical properties, chemical stability in connective tissues and/or to improve surface/interfacial integrity between filling material and connective tissue.
    Type: Application
    Filed: March 21, 2013
    Publication date: March 26, 2015
    Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Anil Kishen, Annie Shrestha
  • Publication number: 20150087656
    Abstract: Prolongation compositions for prolonging the presence of drugs in blood.
    Type: Application
    Filed: November 26, 2014
    Publication date: March 26, 2015
    Inventors: Aida Salatinjants, Robert Salatinjants
  • Patent number: 8986728
    Abstract: The present invention provides an implantable device having a biosoluble coating or a biosoluble body structure comprising a polyelectrolyte and a counterion and the methods of making and using the same.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: March 24, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Syed F. A. Hossainy, Mikael O. Trollsas, Lothar W. Kleiner
  • Publication number: 20150080220
    Abstract: Compositions including a highly branched alpha-D-glucan or modified forms thereof and a solute compound are described herein. The compositions can provide increased water solubility and/or increased rate of dissolution for the solute compound. The compositions can also provide increased stability for the solute compound. Methods for preparing and using compositions including a solute compound and a highly branched alpha-D-glucan are also described.
    Type: Application
    Filed: April 19, 2013
    Publication date: March 19, 2015
    Inventors: Yuan Yao, Jingmin Zhang