Algin Or Derivative Patents (Class 514/779)
  • Publication number: 20150133377
    Abstract: The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 14, 2015
    Inventors: Sarah Mayes, Christine Schmidt
  • Publication number: 20150126619
    Abstract: A process for the formation of an ionic gel comprising contacting a first polyelectrolyte reactant having a backbone comprising a plurality of ?-1,4-glycosidic linkages in the 4C1 conformation and an oligoelectrolyte reactant or second polyelectrolyte reactant, having a backbone containing a plurality of ?-1,4-glycosidic linkages in the 4C1 conformation, in aqueous solution under pH conditions such that one reactant is charged and the other uncharged; adding a donor to adjust the pH such that said uncharged reactant possesses a charge opposite to that of the charged reactant so as to form an ionic gel.
    Type: Application
    Filed: September 14, 2012
    Publication date: May 7, 2015
    Applicant: NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU)
    Inventors: Kjell Morten Varum, Kurt Ingar Draget
  • Patent number: 9023333
    Abstract: The invention relates to the use of a shaped article containing at least one skeleton-forming agent, proteins being excepted, optionally one or more active substances and also optionally one or more auxiliary substances for the purpose of external application, to a process for producing the stated shaped articles, and also to novel shaped articles.
    Type: Grant
    Filed: September 30, 2003
    Date of Patent: May 5, 2015
    Inventors: Stefan Frahling, Ralf Malessa
  • Publication number: 20150118195
    Abstract: The presently disclosed subject matter provides a scalable and electrostretching approach for generating microfibers exhibiting uniaxial alignment from polymer solutions. Such microfibers can be generated from a variety of natural polymers or synthetic polymers. The hydrogel microfibers can be used for controlled release of bioactive agents. The internal uniaxial alignment exhibited by the presently disclosed fibers provides improved mechanical properties to microfibers, contact guidance cues and induces alignment for cells seeded on or within the microfibers.
    Type: Application
    Filed: April 30, 2013
    Publication date: April 30, 2015
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Hai-Quan Mao, Shuming Zhang, Xi Liu, Brian Patrick Ginn
  • Patent number: 8968783
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: March 3, 2015
    Assignee: Covidien LP
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla
  • Patent number: 8962566
    Abstract: Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: February 24, 2015
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Samuel P. McManus, Jennifer Riggs-Sauthier, Xiaoming Shen, Wen Zhang
  • Publication number: 20150044290
    Abstract: Provided is a liquid food composition capable of semi-solidifying in the stomach, which is a one-pack type product containing a water-soluble dietary fiber preliminarily added thereto and in the form of a liquid that can be easily taken, and stably sustains the liquid nature thereof during distribution and storage. The liquid food composition, which is capable of semi-solidifying in an acidic region, comprises a water-soluble dietary fiber (a), a specific metal compound (b), a protein (c) and an emulsifier (d), and the particle size distribution of particles contained in said liquid food composition shows two or more peaks in a neutral region.
    Type: Application
    Filed: September 19, 2014
    Publication date: February 12, 2015
    Applicant: KANEKA CORPORATION
    Inventors: Hiroaki Inoue, Yui Kawashima, Kazuya Hamada, Shinichi Yokota, Hiromi Maeda, Tatsumasa Mae, Jun Tomono
  • Publication number: 20150037388
    Abstract: The invention relates, in one aspect, to a mucoadhesive edible slow dissolving film comprising a salt of alginic acid, an edible cellulose derivative, an edible protein, and edible polymer delaying the dissolution in a physiological fluid of the edible film selected from polyvinylpyrrolidone, a carboxyvinyl polymer and mixtures thereof, in an amount effective to delay the dissolution time of the film in a biological fluid. The edible film is suitable for cicatrizing oral ulcerations or lesions or for forming a layer on oral mucosae or gingiva affected by ulcerations or lesions for protecting against mechanical abrasions, infections or caustic agents.
    Type: Application
    Filed: January 28, 2013
    Publication date: February 5, 2015
    Inventor: Sonia Longo
  • Publication number: 20140348815
    Abstract: Microencapsulation of bioactive and chemical cargo in a stable, cross-linked polymer matrix is presented that results in small particle sizes and is easily scaled-up for industrial applications. A formulation of a salt of an acid soluble multivalent ion, an acid neutralized with a volatile base and one or more monomers that cross-link in the presence of multivalent ions is atomized into droplets. Cross-linking is achieved upon atomization where the volatile base is vaporized resulting in a reduction of the pH of the formulation and the temporal release of multivalent ions from the salt that cross-link the monomers forming a capsule. The incorporation of additional polymers or hydrophobic compounds in the formulation allows control of hydration properties of the particles to control the release of the encapsulated compounds. The operational parameters can also be controlled to affect capsule properties such as particle-size and particle-size distribution.
    Type: Application
    Filed: May 27, 2014
    Publication date: November 27, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Tina Jeoh-Zicari, Herbert B. Scher, Monica C. Santa-Maria, Scott Strobel
  • Patent number: 8883733
    Abstract: The present invention relates to a method of producing a hydrogel matrix comprising cartilage-forming cells wherein alginate, chitosan and cartilage-forming cells are mixed and subsequently polymerized into beads.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: November 11, 2014
    Assignee: Universite De Liege
    Inventors: Yves Henrotin, Frédéric Kesteloot, Christelle Sanchez
  • Publication number: 20140287061
    Abstract: A biocompatible polymeric composition for cross-linking in-situ in a wound is disclosed comprising 1) one or more polyanionic polymers such as alginates or hyaluronates, able to be cross-linked the surface of the wound and 2) one or more polycationic polymers such as chitosan or DEAE-Dextran, that assists in the solidification process as well as speeds up hemostasis without the need for applying pressure. The biocompatible polymeric composition may further comprise a cross-linking agent such as aqueous calcium chloride. The invention encompasses an initial polymeric composition, the solidified matrix cross-linked and integrated at the wound site, including the methods of using, applying, and cross-linking the composition.
    Type: Application
    Filed: November 12, 2012
    Publication date: September 25, 2014
    Applicant: Suneris, Inc.
    Inventor: Joseph A. Landolina
  • Publication number: 20140271596
    Abstract: The present invention relates to an emulsified hydrogel composition and to a production method therefor, wherein, by incorporating between 20 and 30 percent by weight of a gelling solution and an emulsion obtained by mixing between 45 and 60 percent by weight of an aqueous component and between 15 and 30 percent by weight of an oil component, it is possible to simultaneously provide the skin with an aqueous fraction and an oil fraction, and it is possible to enhance functionality due to the inclusion of a high content of a dermatologically active component dissolved in the oil component.
    Type: Application
    Filed: September 12, 2012
    Publication date: September 18, 2014
    Applicant: GENIC CO., LTD.
    Inventors: Sung Jang Kim, Hyong-ii Park, Jae Han Cho, Eun Kyoung Choi, Jae hoon Kwak, Jae Min Lim, Hyun Jun Lim, Jai Hyun Kim, Min Seok Kim, Jin A. Yang, Hyun Oh Yoo, Jong Chul Kim
  • Patent number: 8822551
    Abstract: Disclosed herein is a hyaluronic acid epoxide derivative film comprises a polymer containing a hydroxyl (—OH) terminal group. The film is prepared by allowing an epoxy crosslinker to react with a mixture of hyaluronic acid and a polymer containing a hydroxyl (—OH) terminal group and has improved physical strength, in vivo stability, flexibility, adhesiveness to biological tissue, and biocompatibility.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: September 2, 2014
    Assignee: Genewel Co., Ltd.
    Inventors: Young Woo Lee, Wan Jin Cho, Ji Yeon Jang
  • Publication number: 20140241997
    Abstract: Use of a moulding composition comprising a polymer and a setting agent for wound debridement, wherein said use comprises adding water to said moulding composition to form a moulding fluid, applying said moulding fluid to a surface of a wound, allowing said moulding fluid to set in contact with said surface to form a solid covering on said surface, followed by removing said solid covering from the wound. The alginate composition adheres strongly to bacterial biofilms on the wound, whereby the biofilms are removed with the alginate composition. The moulding composition may be used in conjunction with a staining agent that undergoes a colour change in the presence of bacteria or bacterial polysaccharides to show the presence and removal of the biofilm. Also provided are methods of treating wounds using the compositions.
    Type: Application
    Filed: April 24, 2012
    Publication date: August 28, 2014
    Inventors: Lorna McInroy, Rachael Louise Clark, Michelle Delbono, Lorraine NIsbet, Paul Howard Lowing
  • Publication number: 20140242126
    Abstract: The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.
    Type: Application
    Filed: May 14, 2014
    Publication date: August 28, 2014
    Inventors: Scott Zawko, Christine Schmidt
  • Patent number: 8759282
    Abstract: A film comprising as a film-forming agent an alginate salt of monovalent cation or a mixture of alginate salts containing at least one alginate salt of monovalent cation, the film-forming agent being such that a 10% aqueous solution thereof at a temperature of 20° C. has a viscosity of 100-1000 mPas, as measured at a shear rate of 20 rpm by use of a Brookfield viscometer with a spindle No. 2. A method of preparing the film. The film is useful for delivery of active ingredients to a mammal.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: June 24, 2014
    Assignee: Uppsalagruppen Medical AB
    Inventors: Kjell G Stenberg, Fredrik Hubinette
  • Publication number: 20140120061
    Abstract: The present invention relates to compositions for oral administration. The invention preferably comprises at least one abuse-resistant drug delivery composition for delivering a drug having potential for dose dumping in alcohol, related methods of preparing these dosage forms, and methods of treating a patient in need thereof comprising administering the inventive compositions to the patient. Most preferably, the dosage form includes verapamil. These formulations have reduced potential for abuse. In another formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding.
    Type: Application
    Filed: July 8, 2013
    Publication date: May 1, 2014
    Inventors: Wolfgang Roth, Alexander Burst, Martina Zietsch
  • Publication number: 20140093574
    Abstract: The present invention relates to solid dispersions including, but not limited to, co-processed carbohydrates with different solubilities and concentrations, which have a microcrystalline plate structure. The solid dispersions, excipient systems and formulations of the present invention are highly compactable and durable and when compressed into solid dosage forms demonstrate uniform densification, low friability at low pressures, and and/or relatively constant low disintegration times at various hardnesses. The solid dosage forms of the present invention demonstrate superior organoleptics, disintegration, and/or robustness.
    Type: Application
    Filed: December 5, 2013
    Publication date: April 3, 2014
    Applicant: SPI Pharma, Inc.
    Inventors: John Tillotson, Cecil Propst
  • Patent number: 8685456
    Abstract: The present invention is directed to topical compositions, comprising isoflavone nanoparticle compositions. The isoflavone nanoparticle compositions contain isoflavone in the form of nanoparticles and preferably a carrier. In the topical compositions recrystallization of the isoflavone to bigger particles is avoided.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: April 1, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Raphael Beumer, Chyi-Cheng Chen, Heinz Gutzwiller, Philippe Emmanuel Maillan, Markus Nowotny, Bernd Schlegel, Juergen H. Vollhardt
  • Patent number: 8686053
    Abstract: The present invention discloses an alginic acid and/or its salts with low molecular weight, wherein the weight average molecular weight of the alginic acid is from about 700 to about 4500 Daltons, and the molar ratio of guluronic acid to mannuronic acid in the alginic acid is from about 0.6 to about 19. The present invention also discloses the preparative method of making the alginic acid and/or its salts thereof, and the use of them for treating hypertension, chronic renal failure and postprandial hyperglycemia induced by glycosidase. The present invention further discloses pharmaceutical compositions and foods containing the alginic acid with low molecular weight and/or salts thereof as active component.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: April 1, 2014
    Inventors: Chuanxing Yu, Deshan Li
  • Publication number: 20130289138
    Abstract: Composite material suitable for biomedical use, comprising a first phase consisting of a reticulated hydrogel deriving from a polymer chosen from among polymers N-methyl-amides derivatives of carboxymethylcellulose, alginic acid or carboxymethyl starch and a second phase which comprises a solution of the above polymers.
    Type: Application
    Filed: December 21, 2011
    Publication date: October 31, 2013
    Applicant: LIMACORPORATE SPA
    Inventors: Francesco Segatti, David Mercuri
  • Patent number: 8563618
    Abstract: Disclosed is an agent for skin external preparation which is hardly reduced in viscosity even when stored for a long period under extreme high temperature storage conditions and is therefore stable. The preparation is in an emulsion form, and comprises (1) an alginic acid polyol ester having an esterification degree ranging from 75 to 95% (e.g., alginic acid propylene glycol ester) and/or a salt thereof; (2) a polyvalent metal ion (e.g., a calcium ion); and (3) a 4-alkylresolcinol (e.g., 4-n-butylresolcinol) and/or a salt thereof.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: October 22, 2013
    Assignees: Kuraray Co., Ltd., Pola Chemical Industries Inc.
    Inventors: Hisashi Akamatsu, Masashi Suzuki, Yuji Sakai
  • Publication number: 20130253074
    Abstract: Disclosed herein is a hyaluronic acid epoxide derivative film comprises a polymer containing a hydroxyl (—OH) terminal group. The film is prepared by allowing an epoxy crosslinker to react with a mixture of hyaluronic acid and a polymer containing a hydroxyl (—OH) terminal group and has improved physical strength, in vivo stability, flexibility, adhesiveness to biological tissue, and biocompatibility.
    Type: Application
    Filed: March 22, 2013
    Publication date: September 26, 2013
    Applicant: GENEWEL CO., LTD
    Inventors: Young Woo Lee, Wan Jin Cho, Ji Yeon Jang
  • Publication number: 20130216623
    Abstract: Drug formulations, devices and methods are provided to deliver biologically active substances to the eye. The formulations are delivered into scleral tissues adjacent to or into the suprachoroidal space without damage to the underlying choroid. One class of formulations is provided wherein the formulation is localized in the suprachoroidal space near the region into which it is administered. Another class of formulations is provided wherein the formulation can migrate to another region of the suprachoroidal space, thus allowing an injection in the anterior region of the eye in order to treat the posterior region.
    Type: Application
    Filed: March 15, 2013
    Publication date: August 22, 2013
    Applicant: ISCIENCE INTERVENTIONAL CORPORATION
    Inventor: ISCIENCE INTERVENTIONAL CORPORATION
  • Patent number: 8501822
    Abstract: An ophthalmic composition that, despite containing alginic acid and/or a salt thereof, has improved tackiness during use and provides a satisfactory use feeling. The composition has an improved ability to remain on the eye mucosa. The ophthalmic composition contains (A) alginic acid and/or a salt thereof in combination with (B) hyaluronic acid and/or a salt thereof.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: August 6, 2013
    Assignee: Rohto Pharmaceutical Co., Ltd.
    Inventors: Eri Matsumoto, Yasuko Nishina, Kenichi Haruna, Harumasa Arita, Akiko Kita
  • Publication number: 20130195769
    Abstract: The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.
    Type: Application
    Filed: March 11, 2013
    Publication date: August 1, 2013
    Applicant: FOAMIX LTD.
    Inventor: Foamix Ltd.
  • Patent number: 8455464
    Abstract: A composition for the treatment of adhesions that are formed as a result of an inflammatory response comprising an aqueous formulation containing the polysaccharide dextrin in an effective amount. The invention also discloses a method of treating adhesions that are formed as a result of an inflammatory response.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: June 4, 2013
    Assignee: Innovata Limited
    Inventor: Susan Conroy
  • Publication number: 20130137780
    Abstract: The present invention is a substantially non-adhesive elastic gelatin matrix. The matrix is both non-adhesive to wounds, tissues and organs and is also elastic such that it is flexible. The matrix is a lyophilized mixture of protein(s), polymer(s), cross-linking agent(s) and optional plasticizer(s). The invention also provides methods for making the non-adhesive elastic gelatin matrix.
    Type: Application
    Filed: January 25, 2013
    Publication date: May 30, 2013
    Applicant: COVALON TECHNOLOGIES, INC.
    Inventor: COVALON TECHNOLOGIES, INC.
  • Publication number: 20130129825
    Abstract: The invention relates to the use of an oral dosage form based on microgranules and/or microtablets to reduce the abusive use of at least one active principle contained therein. The aim of the invention is to prevent the diversion of an oral dosage form based on microgranules and/or microtablets containing at least one active principle capable of causing a dependency, a gelling agent, and a gelling activator. The gelling agent and the activator are only brought into contact with each other in the event of diversion by crushing. Said judiciously selected pair of excipients confers a viscosity to the formulation, such that said formulation cannot be administered by injection or does not release the active principle rapidly by forming a gel when it comes into contact with the mucous membrane if nasally administered.
    Type: Application
    Filed: June 7, 2011
    Publication date: May 23, 2013
    Applicant: Ethypharm
    Inventor: Vincent Billoet
  • Publication number: 20130115268
    Abstract: Methods for administering a dermatological agent to a subject are provided. In the subject methods an effective amount of a topical formulation of the dermatological agent is topically applied to a host. The topically applied formulation of dermatological agent is then occluded with a hydrogel patch, where a feature of the hydrogel patch is that it lacks a pharmaceutically active agent. Also provided are methods of treating a subject for a disease condition by administering a dermatological agent to the subject. Also provided are kits for use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications.
    Type: Application
    Filed: December 27, 2012
    Publication date: May 9, 2013
    Applicants: TEIKIKOKU SEIYAKU KABUSHIKI KAISHA, TEIKOKU PHARMA USA, INC.
    Inventors: Teikoku Pharma USA, INC., Teikikoku Seiyaku Kabushiki Kaisha
  • Publication number: 20130115285
    Abstract: An enteric coating composition including about 0.01% to about 10% resin and about 0.01% to about 10% polymer. The enteric coating composition may be applied to a substrate, such as a pharmaceutical, nutraceutical, fruit, vegetable, agricultural product, or industrial product, to form an enteric coating on the substrate. Also provided is a multiple-component system having a first component including a resin and a second component including a polymer, wherein mixing the first component and the second component forms an enteric coating composition having about 0.01% to about 10% resin and about 0.01% to about 10% polymer. Methods for coating a substrate with the enteric coating compositions are also provided.
    Type: Application
    Filed: February 12, 2011
    Publication date: May 9, 2013
    Inventors: Eric H. Van Ness, Beverly A. Schad, Thomas C. Riley, Brian K. Cheng
  • Patent number: 8409621
    Abstract: A method of forming particles, comprises accelerating a first stream comprising a first liquid, applying a charging voltage of at most 1.5 kV to the first stream, and vibrating the first stream, to form particles.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: April 2, 2013
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Kyekyoon Kim, Hyungsoo Choi, Young Bin Choy
  • Publication number: 20130064861
    Abstract: Provided herein according to some embodiments of the invention are methods of inhibiting or preventing calcification of hydrogels. Such methods may include combining the hydrogel with a buffer solution having a pH lower than 7.4; forming a hydrogel by crosslinking alginate in a solution comprising a bisphosphonate compound; and/or forming a hydrogel by crosslinking a polyanionic polymer with a polyvalent cation that is not Ca2+. Compositions that may be used in such methods are also provided herein. Also provided herein according to some embodiments of the invention are methods of bone regeneration and/or formation that include administering a hydrogel that does not encapsulate biological material that affects calcification and/or bone formation to an area of a subject's body that is in need of bone formation and/or regeneration.
    Type: Application
    Filed: February 17, 2011
    Publication date: March 14, 2013
    Inventors: Zvi Schwartz, Christopher S.D. Lee, Hunter R. Moyer, Barbara D. Boyan
  • Publication number: 20130065968
    Abstract: A gel production apparatus includes a liquid ejection device which ejects a gel forming solution containing 0.3 to 10 wt % of sodium alginate and 4 to 60 wt % of glycerin into either one of an aqueous calcium chloride solution containing 1.0 wt % or more of calcium chloride and an aqueous calcium acetate solution containing 1.0 wt % or more of calcium acetate, thereby forming a gel.
    Type: Application
    Filed: September 11, 2012
    Publication date: March 14, 2013
    Applicant: SEIKO EPSON CORPORATION
    Inventor: Kei Hiruma
  • Publication number: 20130058875
    Abstract: The present invention is directed to a capsule comprising a water-soluble compound suitable for the capsule, a non-water soluble excipient suitable for the capsule; and suitable for the capsule, and a mixture of colorant agents, wherein the color of the capsule may be in the range of 15<L<90; ?30<a<+75; ?37<b<+46 as measured in accordance with the Lab color space. The present invention further includes capsules containing a filling such as food, medicine, cosmetics, agrichemicals, feed or active biological ingredient.
    Type: Application
    Filed: October 17, 2011
    Publication date: March 7, 2013
    Inventors: Cale E. Murray, Juan Carlos Arriola Diaz
  • Publication number: 20130017264
    Abstract: A drug delivery system which comprises alginate tube that is prepared by coating a substrate with alginate gel. One or more therapeutic drugs may also be present in the alginate gel or in the cavity of the tube. The activity of the alginate drug delivery system is highly adjustable so that the release may be controlled as required. The rate at which the system releases the drug and the concentration of the drug released can be adjusted by varying; the number of layers of the alginate tubes, the number of open or closed ends of the tubes, or the number of tube layers containing the drug.
    Type: Application
    Filed: July 15, 2011
    Publication date: January 17, 2013
    Inventors: Jayant J. KHANDARE, Sanjay P. Boldhane
  • Publication number: 20120269862
    Abstract: An ophthalmic composition is disclosed having a viscosity enhancement system comprised of two different viscosity enhancing agents. The aqueous composition contains a first viscosity enhancing agent that provides enhanced viscosity upon dispensing of the composition to the eye and a second viscosity agent that increases viscosity (e.g., gels or partially gels) after dispensing of the composition to the eye to provide extended viscosity enhancement of the composition.
    Type: Application
    Filed: April 19, 2012
    Publication date: October 25, 2012
    Inventors: Masood A. Chowhan, Malay Ghosh
  • Publication number: 20120237477
    Abstract: Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.
    Type: Application
    Filed: May 25, 2012
    Publication date: September 20, 2012
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Eugene Michal, Shubhayu Basu, Hai-Chien Kuo
  • Publication number: 20120225101
    Abstract: Biomaterials that support cell attachment and growth are provided. In one aspect, biomaterials are provided comprising a first polymer matrix comprising reactive amino moieties and a second polymer matrix that interpenetrates with the first polymer matrix, where the second polymer matrix comprises a poly(alkylene oxide) comprising two or more alkylene oxide oligomers joined by gamma-thioether carbonyl linkages. In another aspect, biomaterials are provided comprising at least one biopolymer comprising amino groups, thiol groups, and bifunctional modifiers connecting at least some of the amino groups to at least some of the thiol groups; and at least one poly(alkylene oxide) cross-linked to at least two thiol groups of the biopolymer. The biomaterials may further comprise a pharmacologically active agent or cells. Methods of administering such biomaterials to a patient in need thereof are also provided.
    Type: Application
    Filed: March 2, 2012
    Publication date: September 6, 2012
    Inventors: Weiyuan J. KAO, Yao Fu
  • Publication number: 20120189669
    Abstract: This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.
    Type: Application
    Filed: May 23, 2010
    Publication date: July 26, 2012
    Applicant: CARTIHEAL (2009) LTD.
    Inventors: Nir Altschuler, Razi Vago
  • Patent number: 8221783
    Abstract: Described herein are implantable medical devices comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. The triggerable bioadhesive property of the polymer can be triggered or activated by exposure to a stimulus. Also, the present invention pertains to methods of making an implantable medical device comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue.
    Type: Grant
    Filed: September 10, 2008
    Date of Patent: July 17, 2012
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Michael N. Helmus, Yixin Xu, Barron W. Tenney, Paul L. Valint, Shrirang V. Ranade
  • Publication number: 20120177702
    Abstract: This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.
    Type: Application
    Filed: May 23, 2010
    Publication date: July 12, 2012
    Applicant: CARTIHEAL (2009) LTD.
    Inventors: Nir Altschuler, Razi Vago
  • Publication number: 20120164195
    Abstract: Personal care products, including cosmetics, are provided as solid, water-soluble polymeric films which adhere to a human integument when wetted. The invention also relates to such films having plural laminated layers, at least two of which possess different cosmetic or therapeutic characteristics.
    Type: Application
    Filed: November 30, 2011
    Publication date: June 28, 2012
    Applicant: AVON PRODUCTS, INC.
    Inventors: Tao Zheng, Leona G. Fleissman, Xiaolan Wei
  • Publication number: 20120108676
    Abstract: Disclosed are aerosol-mediated methods for synthesizing particles for biomedical and drug delivery applications. The method is based on the production of particles from sprayed polymeric micro or nano-droplets obtained by, for example, an air-jet nebulization process that is followed by gelation and/or hardening in a crosslinking fluid, non-solvent, precipitating solvent, or supercritical fluid.
    Type: Application
    Filed: November 1, 2011
    Publication date: May 3, 2012
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hugh D.C. Smyth, Ibrahim M. El-Sherbiny
  • Publication number: 20120100217
    Abstract: Disclosed herein is a polymeric material comprising a conductive polymer substantially homogeneously distributed within a hydrogel. Also disclosed are methods for making the polymeric material and uses for the polymeric material.
    Type: Application
    Filed: June 9, 2011
    Publication date: April 26, 2012
    Applicant: NEWSOUTH INNOVATIONS PTY LIMITED
    Inventors: Rylie Adelle GREEN, Laura Anne POOLE-WARREN, Sungchul BAEK, Penny Jo MARTENS
  • Publication number: 20120093926
    Abstract: The invention relates to a gastric resistant pharmaceutical or nutraceutical composition, comprising a core, comprising a pharmaceutical or nutraceutical active ingredient and a gastric resistant coating layer onto the core, wherein the release of the pharmaceutical or nutraceutical active ingredient is not more than 15% under in-vitro conditions at pH 1.
    Type: Application
    Filed: April 13, 2011
    Publication date: April 19, 2012
    Applicant: Evonik Roehm GmbH
    Inventors: Shraddha Ashok Bodinge, Priyanka Bansilal Haksar, Seema Yashwant Gawde, Hemant Karbhari Pagar, Hans-Ulrich Petereit
  • Publication number: 20120089084
    Abstract: A plasma coating device for treating a wound comprises a plasma chamber having: one or more electrodes, a gas supply inlet, a plasma outlet exposed to ambient pressure, and an ignition system operatively connected to the electrodes for providing a non-thermal equilibrium plasma within the plasma chamber. An aerosol delivery system is operable to introduce a bioresorbable material as an aerosol into the plasma, to produce a coating on the wound surface.
    Type: Application
    Filed: June 15, 2010
    Publication date: April 12, 2012
    Inventors: Joe O'Keeffe, Peter Dobbyn, John O'Donoghus, Liam O'Neil
  • Publication number: 20120088832
    Abstract: A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.
    Type: Application
    Filed: October 7, 2011
    Publication date: April 12, 2012
    Applicant: Board of Regents, The University of Texas System
    Inventors: Sarah Mayes, Christine E. Schmidt, Daniel Peterson
  • Publication number: 20120082723
    Abstract: It is an object to provide a coating composition, which is used for an orally-administered preparation, the administering property of which has been improved, and/or an easily administrable preparation that does not affect dissolution property. The aforementioned object can be achieved using a coating composition comprising a first thickener selected from the group consisting of a carboxyvinyl polymer and sodium alginate, a polyvalent metal compound, and at least one type of a second thickener selected from the group consisting of xanthan gum, guar gum and sodium alginate, with the proviso that when the first thickener is sodium alginate the second thickener is not sodium alginate, or using a coating composition comprising, as thickeners, hydroxypropylmethylcellulose and sugar or sugar alcohol having a solubility at 20° C. of 30 or more.
    Type: Application
    Filed: September 30, 2011
    Publication date: April 5, 2012
    Inventors: Yumio Kudou, Kuniomi Warabino
  • Patent number: 8142562
    Abstract: The invention relates to a curable dental retraction composition for reacting gingiva from a prepared tooth structure. The composition comprises an alginate, a di- and/or trivalent ion source, water, a retarder and a filler.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: March 27, 2012
    Assignee: 3M Innovative Properties Company
    Inventors: Thomas Klettke, Ruediger Hampe