Carboxylic Acid Or Salt Thereof Patents (Class 514/784)
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Publication number: 20120269739Abstract: The invention relates to a cosmetic, pharmaceutical, dermatological, nutraceutical or oral cosmetic composition having, as main preserving system, a mild preserving system formed from compounds with a broad antimicrobial spectrum, which have only one pKa, the said pKa being greater than or equal to 10, the said mild preserving system being present in a content strictly greater than or equal to 1% by weight relative to the weight of the said composition.Type: ApplicationFiled: September 16, 2010Publication date: October 25, 2012Applicant: L'OREALInventors: Maria Dalko, Geraldine Lerebour, Sylvie Cupferman
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Publication number: 20120269888Abstract: The invention is directed to a barrier composition, to a vehicle comprising said barrier composition, to a layer comprising said barrier composition, to a foodstuff comprising said vehicle or layer, to a pharmaceutical or nutraceutical composition comprising said vehicle or layer, to a method for protecting one or more active ingredients, and to the use of said barrier composition. The barrier composition of the invention comprises: a hydrophobic organic phase; and 0.1-75 vol. %, based on the total volume of the barrier composition, of biodegradable solid plate-like particles.Type: ApplicationFiled: October 20, 2010Publication date: October 25, 2012Applicant: Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNOInventors: Jan Matthijs Jetten, Jacobus Eversdijk, Kjeld Jacobus Cornelis van Bommel, Johannes Wilhelmus Timmermans, Aafke Tessa ten Cate, Theodoor Maximiliaan Slaghek
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Patent number: 8293784Abstract: The invention relates to the use of ?-amino acid derivatives for improving the solubility of sparingly soluble substances in water or aqueous solutions, and to mixtures and preferred compositions.Type: GrantFiled: November 27, 2008Date of Patent: October 23, 2012Assignee: Merck Patent GmbHInventors: Thomas Rudolph, Herwig Buchholz, Michaela Oberle
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Publication number: 20120264834Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. Preferred delivery agents include, but are not limited to, N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC), N-(10-[2-hydroxybenzoyl]amino)decanoic acid (SNAD), and sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC). The invention also provides methods of preparing the disodium salt, ethanol solvate, and hydrate and compositions containing the disodium salt, ethanol solvate, and/or hydrate.Type: ApplicationFiled: May 25, 2012Publication date: October 18, 2012Applicants: NOVARTIS AG, Emisphere Technologies, Inc.Inventors: William E. BAY, Rajesh K. AGARWAL, Kiran CHAUDHARY, Shingai MAJURU, Michael M. GOLDBERG, JoAnne P. CORVINO, Moise AZRIA, Joseph M. AULT, Simon D. BATEMAN, Subash PATEL, Joseph SIKORA, Rebecca F. YANG, Joseph L. ZIELINSKI
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Publication number: 20120264832Abstract: A low inflammatory oil composition and method for supplementing feed, nutrition and diet systems with omega-3 to omega-6 balanced oils comprised of a synergistic blend of at least two oils. The composition further comprises a synergistic blend of long chain omega-3 oil as a means to further increase the nutritional value. The composition further provides an effective increase in reducing inflammation for therapeutic, and pharmacological treatment in addition to general nutrition and diet systems.Type: ApplicationFiled: March 23, 2012Publication date: October 18, 2012Inventor: Michael H. Gurin
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Publication number: 20120264611Abstract: The invention relates to pesticide preparations that contain one or more pesticides and one or more N-substituted 2-pyrrolidone-4-carboxylic acid derivatives and to the use of said pesticide preparations for controlling and/or combating weeds, fungal diseases, or insect infestation. The N-substituted 2-pyrrolidone-4-carboxylic acid derivatives act as adjuvants, emulsifiers, dispersants, and/or wetting agents in the pesticide preparations.Type: ApplicationFiled: September 18, 2010Publication date: October 18, 2012Applicant: CLARIANT FINANCE (BVI) LIMITEDInventors: Andreas Wacker, Joachim Hess, Robert Milbradt, Franz-Xaver Scherl
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Patent number: 8287907Abstract: There are described solid compositions or examining drug solubility comprising bile salts and phospholipids, optionally containing buffer components suitable for preparation of intestinal media that simulate the composition of the intestinal fluids in fasted and fed states.Type: GrantFiled: November 10, 2006Date of Patent: October 16, 2012Assignee: Phares Pharmaceutical Research, N.V.Inventors: Steve Leigh, Matthew Louis Steven Leigh, Peter Van Hoogevest, Daniel Streich, Jacques Quinton
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Publication number: 20120258911Abstract: The present invention provides phenylalkylcarboxylic acid compounds and compositions containing such compounds which facilitate the delivery of biologically active agents.Type: ApplicationFiled: May 17, 2012Publication date: October 11, 2012Applicant: Emisphere Technologies, Inc.Inventors: David Gschneidner, Stephen V. Pusztay
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Publication number: 20120251460Abstract: The present invention relates to the use, in a cosmetic, dermatological or pharmaceutical composition, of at least one compound of formula (I): in which: R2 represents a hydrogen atom or a methyl or ethyl radical; R3 represents a linear C1-C12 alkyl radical, optionally substituted with a hydroxyl group; or a linear C2-C12 alkenyl radical, optionally substituted with a hydroxyl group; as a preserving agent. The invention also relates to certain novel compounds and to the cosmetic, dermatological or pharmaceutical compositions comprising them.Type: ApplicationFiled: September 16, 2010Publication date: October 4, 2012Applicant: L'OREALInventor: Maria Dalko
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Publication number: 20120252906Abstract: A composition for increasing the bioavailability of an active pharmaceutical ingredient (“API”) in humans and animals, comprising a first water soluble surfactant having a cloud point greater than about 37° C., a second water soluble surfactant having a cloud point greater than about 37° C., wherein a mixture of the first surfactant and the second surfactant comprises a cloud point less than about 37° C.Type: ApplicationFiled: November 30, 2011Publication date: October 4, 2012Inventor: Bhiku G. Patel
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Publication number: 20120251641Abstract: A method of controlling a target pest is disclosed that comprises providing a microemulsion pesticide formulation comprising an active pest control ingredient and a microemulsifying agent, wherein the microemulsifying agent comprises a mixture of unsaturated C12-C26 fatty acids and/or salts thereof and saturated C6-C14 fatty acids and/or salts thereof, and the active pest control ingredient comprises two or more compounds that act synergistically to control the target pest; and applying an effective amount of the microemulsion pesticide formulation to the target pest or to a surface associated with the target pest. The active pest control ingredient and the microemulsifying agent may act synergistically in the method to control the target pest. The control exhibited by the formulation may be knockdown, kill, or repellency. The method may involve long-term residual effects.Type: ApplicationFiled: April 1, 2010Publication date: October 4, 2012Applicant: TYRA TECH, INC,Inventors: Essam Enan, Peter J. Porpiglia, Gregory J. Lindner
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Publication number: 20120245156Abstract: The present invention relates to a method for preparing an oral lyophilizate composition comprising: a) forming a liquid phase by using at least one homogenising agent having tensioactive properties, said liquid phase comprising at least an active pharmaceutical ingredient, a filler and/or a binding agent and a solvent, b) lyophilizing said liquid phase to form the oral lyophilizate composition.Type: ApplicationFiled: June 4, 2012Publication date: September 27, 2012Applicant: CEPHALON FRANCEInventor: Thanh-Tam Nguyen
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Patent number: 8273378Abstract: Dialysis solutions comprising pyrophosphates and methods of making and using the dialysis solutions are provided. In an embodiment, the present disclosure provides a dialysis solution comprising a stable and therapeutically effective amount of pyrophosphate. The dialysis solution can be sterilized, for example, using a technique such as autoclave, steam, high pressure, ultra-violet, filtration or combination thereof. The dialysis solution can be in the form of a concentrate.Type: GrantFiled: January 14, 2010Date of Patent: September 25, 2012Assignees: Baxter International, Inc., Baxter Healthcare S.A.Inventors: Bruce L. Riser, Paul Zieske, Sujatha Karoor, Himanshu D. Patel
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Patent number: 8268341Abstract: This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10?7 reciprocal second.Type: GrantFiled: April 23, 2012Date of Patent: September 18, 2012Assignee: Intarcia Therapeutics, Inc.Inventors: Stephen A. Berry, Pamela J. Fereira, Houdin Dehnad, Anna Muchnik
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Publication number: 20120232168Abstract: A liquid concentrate for preserving cosmetic products which includes a combination of carboxylic component being sodium benzoate and an alcohol component being a mixture of phenoxy ethanol and benzyl alcohol, in a water, where the combination is greater than 45% by weight of the liquid concentrate.Type: ApplicationFiled: May 17, 2012Publication date: September 13, 2012Applicant: AIR LIQUIDE SANTE (INTERNATIONAL)Inventors: Wolfgang BEILFUSS, Gisela HAHN, Klaus WEBER, Ralf GRADKE
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Publication number: 20120231093Abstract: The present invention relates to a method for preparing nanoscale or amorphous particles using solid fat as a solvent. According to the present invention, nanoscale or amorphous particles of active ingredients are prepared by using fat as a solvent, wherein the fat is in solid phase at room temperature. The nanoscale or amorphous particles of active ingredients can be advantageously used in medicine, cosmetics, functional foods or the like.Type: ApplicationFiled: May 24, 2012Publication date: September 13, 2012Inventor: Kab-Sig KIM
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Publication number: 20120231071Abstract: Compositions are disclosed which have as a component thereof an inhibitor of the enzymatic production of 3-deoxyglucosone (3DG) from fructoselysine and/or an inactivator of 3DG, and which are useful for the treatment or prophylaxis of a condition or disease state that is alleviated by inhibiting such 3DG production. Methods of using such compositions, e.g., for improving the appearance, texture and/or elasticity of aging skin, are also disclosed.Type: ApplicationFiled: May 24, 2012Publication date: September 13, 2012Inventors: Annette Tobia, Marcy Alice, Bangying Su, Takashi Niwa
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Publication number: 20120231072Abstract: A thermo-responsive hydrogel, including a biocompatible monomer and/or polymer having an amino acid side chain. The hydrogel is thermo-responsive at a physiological temperature, and can include, incorporate, or encapsulate a treatment agent, such as a drug composition, a biomolecule, and/or a nanoparticle. The hydrogel is useful in delivering the treatment agent. The hydrogel is in a first physicochemical state for administration to a mammal. The hydrogel is thermo-responsive at a physiological temperature of the mammal, and changes to a second physicochemical state that is more solid than the first physicochemical state. In the second physicochemical state the thermo-responsive hydrogel releases the treatment agent.Type: ApplicationFiled: March 11, 2011Publication date: September 13, 2012Applicants: Chemisches Institut Schaefer AG, Illinois Institute of TechnologyInventors: Jennifer J. KANG-MIELER, Eric BREY, Victor PEREZ-LUNA, Bin JIANG, Pawel DRAPALA, Hans Hitz, Rolf Schaefer
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Publication number: 20120219628Abstract: There is provided a fast dissolving solid dosage form adapted for the release of a biologically active material in the oral cavity wherein the dosage form comprises at least one biologically active material, and at least one matrix forming agent, wherein the dosage form substantially dissolves in the oral cavity. A method of producing the same and a kit comprising the same are also provided.Type: ApplicationFiled: October 26, 2010Publication date: August 30, 2012Applicant: IX BIOPHARMA PTE LTDInventors: Chin Beng Stephen Lim, Vivian Bruce Sunderland, Yip Hang Eddy Lee
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Publication number: 20120213839Abstract: Coatings for medical devices, methods of making the coatings, and methods of using them are described.Type: ApplicationFiled: February 24, 2012Publication date: August 23, 2012Inventors: Keith M. Faucher, Hui Tang, Lisa Rogers, Joseph Ferraro, Paul Martakos, Steve A. Herweck, Theodore Karwoski
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Patent number: 8246987Abstract: A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided. A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3.Type: GrantFiled: March 16, 2011Date of Patent: August 21, 2012Assignee: Takeda Pharmaceutical Company LimitedInventors: Kazumichi Yamamoto, Akiko Yamada, Yoshio Hata
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Publication number: 20120207738Abstract: The present invention relates to a treatment by pulmonary delivery of a bioscavenger to animals as an effective antidote to prevent toxicity produced by exposure of an animal to nerve agents and other toxic substances.Type: ApplicationFiled: April 23, 2012Publication date: August 16, 2012Inventor: Yvonne J. Rosenberg
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Publication number: 20120201871Abstract: Method for producing liposomes in a composition for skin permeation are provided. A composition that includes water, skin lipids, butters having linoleic acid and linolenic acid, Pracaxi oil, Plukenetia Volubilis seed oil, and phospholipids is provided. The composition is dispersed in a vessel using a high shear homogenizer. Negative pressure is created in the vessel such that liposomes of 5-20 microns are produced thereby providing for increased skin permeation of active ingredients added to the composition.Type: ApplicationFiled: February 7, 2011Publication date: August 9, 2012Applicant: PROFESSIONAL COMPOUNDING CENTERS OF AMERICA, LTD.Inventors: DANIEL BANOV, AUGUST S. BASSANI
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Publication number: 20120196942Abstract: A liquid crystal composition contains liquid crystals containing one kind of or two or more kinds of silicone surfactants, a phenyl-modified silicone oil and water. The liquid crystal composition of the present invention contains 5 to 95% by weight in total of one kind of or two or more kinds of silicone surfactants, 0.1 to 90% by weight of a phenyl-modified silicone oil and 0.1 to 90% by weight of water. The liquid crystal composition of the present invention can solubilize hydrophobic compounds having poor solubility (for example, hydrocarbon oils such as squalane, fatty acids such as oleic acid and lipoic acid and ester oils such as cetyl isooctanoate) and is thus useful, for example, as toiletry materials and cosmetic materials.Type: ApplicationFiled: September 29, 2010Publication date: August 2, 2012Inventors: Yoko Yamaguchi, Yuji Yamashita, Takeshi Hamasaki
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Publication number: 20120195940Abstract: Nanolipidic Particles (NLPs) having average mean diameters of 1 nm to 20 nm are made from a precursor solution. NLPs can be loaded with a desired passenger molecule. Assemblies of these particles, called NLP assemblies, result in a vehicle population of a desired size. Single application or multifunction NLP assemblies are made from the loaded NLPs and range in size from about 30 to about 200 nm. A method of using preloaded NLPs to make larger carrier vehicles or a mixed population provides increased encapsulation efficiency. NLPs have application in the cosmetics, pharmaceutical, and food and beverage industries.Type: ApplicationFiled: April 10, 2012Publication date: August 2, 2012Applicant: DERMAZONE SOLUTIONS INC.Inventor: Michael W. Fountain
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Publication number: 20120189666Abstract: This invention relates to microparticles and/or nanoparticles containing a delivery agent and/or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent.Type: ApplicationFiled: November 23, 2011Publication date: July 26, 2012Applicant: Emisphere Technologies, Inc.Inventors: Nikhil Dhoot, Halina Levchik, Shingai Majuru, George Klein, Jamila Harris, Puchun Liu, Steven Dinh, Jun Liao, Jongbin Lee, Ehud Arbit, Nai Fang Wang
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Patent number: 8227409Abstract: Disclosed herein are fumaryl diketopiperazine (FDKP) compositions and microparticles having a specific trans isomer content of about 45% to about 65%. The FDKP microparticles can comprise a drug such as an endocrine hormone, including, peptide, including, insulin, glucagon, parathyroid hormones and the like and can be used to make a powder formulation for pulmonary delivery of the drug.Type: GrantFiled: June 11, 2010Date of Patent: July 24, 2012Assignee: MannKind CorporationInventors: Kelly S. Kraft, Karla Somerville
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Publication number: 20120184630Abstract: A compound of formula (I) wherein R1 and R2 are independently selected from hydrogen, methyl, ethyl, propyl and isopropyl; or R1 and R2 together form a saturated or monounsaturated 5- or 6-membered hydrocarbon ring, as represented by the arcuate dotted line; R3 is selected from methyl and ethyl; R4 is selected from methyl, ethyl, propyl, isopropyl, cyclopropyl, butyl, isobutyl, cyclobutyl and cyclopentyl; R5 is selected from hydrogen and methyl, and the dotted line between positions 3? and 4? represents an optional double bond. The compounds have a musk odour and are useful in fine and functional fragrances.Type: ApplicationFiled: September 10, 2010Publication date: July 19, 2012Inventors: Philip Kraft, Urs Mueller
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Publication number: 20120183531Abstract: The present invention is related to methods for preventing or retarding (i.e., inhibiting) yellow color or peroxide formation in a composition. The present invention is also related to methods of reducing or decreasing the amount of yellow color or peroxide in a composition. More specifically, the present invention relates to the use of an antioxidant, an oxygen scavenger, pH, a chelating agent, and/or at least two factors in the methods of the invention. The present invention is also related to methods for predicting the rate of yellow color or peroxide formation in a composition.Type: ApplicationFiled: July 13, 2010Publication date: July 19, 2012Applicant: BIOGEN IDEE MA INCInventors: Karin Lucas, Kevin Maloney
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Publication number: 20120184627Abstract: The invention concerns a co-processed additive for a solid-dose pharmaceutical composition, the additive comprising from about 50% to 99.5% by weight of at least one pharmaceutical compression aid and from about 0.5% to 50% by weight of at least one pharmaceutical lubricant, the melting point of said compression aid(s) being higher than the melting point of said lubricant(s). The co-processed additive may be in the form of a physically bound composite whereby the lubricant is associated with the surface of the compression aid particles.Type: ApplicationFiled: September 24, 2010Publication date: July 19, 2012Inventors: Michael Crowley, Amanda Gage, Jack Maegli, Timothy O'Reilly
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Patent number: 8222233Abstract: Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.Type: GrantFiled: April 15, 2011Date of Patent: July 17, 2012Assignee: BioMolecular Products, Inc.Inventors: David W. Yesair, Walter A. Shaw, Stephen W. Burgess, Robert Travis Mckee
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Publication number: 20120177709Abstract: An aqueous, low pH structured surfactant composition, contains, based on 100 parts by weight of the composition, from about 3 parts by weight to about 40 parts by weight of one or more anionic surfactants selected from anionic phosphate ester surfactants, anionic sulfonate surfactants, and anionic carboxylate surfactants, wherein the composition exhibits a pH of less than about 5, exhibits shear-thinning viscosity, and is capable of suspending water insoluble or partially water soluble components.Type: ApplicationFiled: March 16, 2012Publication date: July 12, 2012Applicant: RHODIA OPERATIONSInventors: Seren FRANTZ, Stewart Alexander Warbuton
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Publication number: 20120178828Abstract: The present invention relates to processes for the preparation of a flavoring concentrate, to a flavoring concentrate which can be prepared by a process according to the invention, to products comprising one or more flavoring concentrates according to the invention, and to processes for the concentration of flavoring and/or aromatic substances.Type: ApplicationFiled: March 15, 2012Publication date: July 12, 2012Applicant: SYMRISE AGInventors: Ingo Reiss, Harry Erfurt, Frank Ott, Günter Kindel, Bernd Gabriel
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Publication number: 20120172229Abstract: The present invention comprises formulations for use as pesticides and their applications. The formulations include a monoalkylsulfosuccinnate as a hydrotrope. The pesticide may be a herbicide comprising glufosinate-ammonium.Type: ApplicationFiled: September 21, 2009Publication date: July 5, 2012Applicant: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.Inventors: Giao Vinh Nguyen, Mark Alexander
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Publication number: 20120171249Abstract: Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, and one or more surfactants. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.Type: ApplicationFiled: October 31, 2007Publication date: July 5, 2012Inventors: Theodore C. Annis, James R. Baker, JR., Tarek Hamouda
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Publication number: 20120172451Abstract: The present invention relates to a cleaning fluid, in particular a cleaning fluid for cleaning surfaces.Type: ApplicationFiled: December 16, 2011Publication date: July 5, 2012Inventor: Navjeet Kaur MATHARU
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Publication number: 20120164086Abstract: The present invention provides a production method that can easily produce an O/W emulsion composition without using a special cooling apparatus and be economical. The production method of an O/W emulsion composition comprising: emulsifying, at 70° C. or higher, an oil phase with a portion of a water phase to prepare an emulsified part, wherein the oil phase comprises (A) a nonionic surfactant, (B) a linear higher alcohol that has 16 or more carbon atoms and can form an ?-gel in water with the nonionic surfactant, and (C) an oil component, and the water phase comprises (D) water; mixing the remaining main water phase at 10 to 35° C. with the emulsified part while being stirred, to cool the emulsified part with continuous stirring to the lower temperature limit, or lower, of a temperature range wherein the oil phase forms an ?-gel in the water phase; and then stopping the stirring.Type: ApplicationFiled: September 2, 2010Publication date: June 28, 2012Applicant: SHISEIDO COMPANY, LTD.Inventors: Hidefumi Araki, Reiji Miyahara
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Publication number: 20120157313Abstract: The present invention comprises formulations for agricultural use comprising a surfactant and pesticide. The surfactants comprise nitrogen containing surfactants with N+—CH2COO?, N+—CH2COOCH3, N—CH2COO?M+, N—CH2CH2COO?M+, and/or amine oxide functionalities which enhance the pesticide activity. The pesticides include herbicides, fungicides and insecticides.Type: ApplicationFiled: August 30, 2010Publication date: June 21, 2012Applicant: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.Inventors: Shawn Zhu, Joshua Jurs, Elliot Isaac Band, Michael Walters
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Publication number: 20120157317Abstract: The invention provides a composition in concentrated form (“the concentrate”) for dilution with water in the preparation of an agricultural composition for application to crops, soil or animals, comprising a carbohydrate-based pH modifying agent and a pH indicator. The agricultural composition comprises an agricultural chemical whose agricultural activity varies with the pH of the water. The proportions of the pH indicator and the pH modifying agent in the concentrate are selected so that when the concentrate is diluted with an appropriate amount of water, the pH indicator indicates visually by colouration of the composition, whether or not the pH of the water is suitable for acceptable agricultural activity of the chemical. The invention also provides a process for preparing the agricultural composition by mixing the concentrate with water, and adding the agricultural chemical to the composition, if it is not already present in the concentrate.Type: ApplicationFiled: July 27, 2011Publication date: June 21, 2012Applicant: NUTRIAG LTDInventors: Kelly S.E. Tanaka, Martin David Bloomberg
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Publication number: 20120156249Abstract: The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA: sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism.Type: ApplicationFiled: August 4, 2010Publication date: June 21, 2012Applicant: ORGANOBALANCE GMBHInventors: Christine Lang, Andreas Raab
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Publication number: 20120149719Abstract: A powder-particle dosage form obtained by granulating an excipient and/or a disintegrating agent with a liquid in which a bitter taste masking base is dissolved and/or suspended, and a drug having solubility in water (20° C.) of not higher than 1 g/mL is dissolved or suspended, or a tablet obtained by compressing the powder-particle dosage form could mask bitter taste of a drug.Type: ApplicationFiled: February 23, 2012Publication date: June 14, 2012Inventors: Yoichi TANIGUCHI, Yoshitaka Tomoda, Kazuaki Yoshioka, Toshitada Toyoda, Chieko Imamoto
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Patent number: 8197833Abstract: The invention relates to a liquid concentrate for preserving cosmetic products which comprises a combination of carboxylic acid salts chosen from the salts of benzoic acid, propionic acid, salicylic acid, sorbic acid, 4-hydroxybenzoic acid, dehydracetic acid, formic acid or 10-undecylenic acid and alcohols chosen from 2-phenoxyethanol, benzyl alcohol, phenethyl alcohol, 1-phenoxypropan-2-ol, 3-(4-chlorophenoxy)-1,2-propanediol, chlorobutanol or 2,4-dichlorobenzyl alcohol in a solvent, where the active ingredient content is greater than 45% by weight.Type: GrantFiled: January 13, 2009Date of Patent: June 12, 2012Assignee: Air Liquide Sante (International)Inventors: Wolfgang Beilfuss, Gisela Hahn, Klaus Weber, Ralf Gradke
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Publication number: 20120142788Abstract: Cosmetic or dermatological emulsions with a content of one or more acyl arginates of the formula, wherein R can have values from 5 through 17 and preferably represents an unbranched alkyl chain of 11 C atoms (=lauroyl arginate).Type: ApplicationFiled: May 5, 2010Publication date: June 7, 2012Applicant: BEIERSDORF AGInventors: Manuela Koehler, Antonia Wagner, Kerstin Skubsch
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Publication number: 20120132204Abstract: An inhaler includes a first body member and a second body member fit closely together to form an inhaler body, and an outlet. The first body member has a medicament chamber containing a unit dose of powdered medicament. A seal such as a foil strip seals the medicament chamber and extends outwardly of the inhaler body. In use, one end of the seal can be grasped by a user and withdrawn, fully or partially, from the inhaler body, to release the powdered medicament from the medicament chamber. The second body member includes a medicament collection well in which the medicament is collected upon its release from the medicament chamber. The medicament collection well forms part of an airway connecting into the outlet. In use, air can be drawn by inhalation at the outlet to entrain the powder medicament in the collection well for inhalation by a user.Type: ApplicationFiled: February 9, 2012Publication date: May 31, 2012Applicant: INNOVATA BIOMED LIMITEDInventors: Samuel W. Lucking, Glen P. Martyn
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Publication number: 20120136051Abstract: The present disclosure relates to rheology modified, low foaming aqueous antimicrobial compositions. The compositions are phase stable under acidic conditions, and do not need to be rinsed from the surface to which they are applied. The present disclosure further relates to methods of use thereof.Type: ApplicationFiled: May 20, 2011Publication date: May 31, 2012Applicant: ECOLAB USA INC.Inventors: Junzhong Li, Steven J. Lange, Richard K. Staub, David D. McSherry
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Publication number: 20120129955Abstract: Compositions comprising sulfo-estolides and alkyl ester sulfonates are described. Detergent formulations, such as laundry detergents, softeners, and other materials, containing any of these materials are disclosed, as well as personal care formulations, hard surface cleaner formulations, and automatic dishwasher detergent formulations. Laundry methods employing these formulations are also disclosed. These formulations are useful as laundry detergents and can be biodegradable, heavy duty liquids, 2× or 3× and up to 6× concentrates, low foaming, and/or effective in a high efficiency washing machine.Type: ApplicationFiled: January 26, 2012Publication date: May 24, 2012Inventors: Randal J. Bernhardt, Lourdes R. Alonso, Gregory P. Dado, Eddie I. Filipovic, Christopher A. Gariepy, Ronald A. Masters, Dennis S. Murphy, Jacqueline Maas Pytel, Branko Sajic, Irene Shapiro, Jeremy Aaron Weitgenant
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Publication number: 20120128601Abstract: The invention relates to mixtures of alkyl sulfosuccinate monoesters of general formulas (I) and/or (II), in which R represents a linear or branched, saturated or unsaturated alkyl group having 6 to 22 C atoms, and X and Y independently represent a hydrogen atom or a cation that can form a water-soluble salt and is selected from among the group composed of alkali metal, alkaline earth metal, ammonia, and organic ammonia. The invention is characterized in that the mixture contains 30 to 70 percent by weight of C16 alkyl sulfosuccinate monoester and 30 to 70 percent by weight of C18 alkyl sulfosuccinate monoester, the percentages by weight being in relation to the total amount of alkyl sulfosuccinate monoesters of formulas (I) and (II). The invention also relates to the use of said mixtures in cosmetic and/or pharmaceutical preparations.Type: ApplicationFiled: October 15, 2009Publication date: May 24, 2012Inventors: Ansgar Behler, Rainer Eskuchen, Almud Folge, Helga Gondek, Catherine Weichold
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Publication number: 20120114705Abstract: A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.Type: ApplicationFiled: November 9, 2011Publication date: May 10, 2012Inventors: Horst Georg ZERBE, Jian-Hwa Guo, Anthony Serino
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Patent number: 8173150Abstract: This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10?7 reciprocal second.Type: GrantFiled: March 8, 2011Date of Patent: May 8, 2012Assignee: Intarcia Therapeutics, Inc.Inventors: Stephen A. Berry, Pamela J. Fereira, Houdin Dehnad, Anna Muchnik
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Publication number: 20120094988Abstract: Treatment with N-(2-phenylethyl)succinamic acid or its salts protects against inhibition of growth by a neonicotinoid compound applied as a seed treatment or applied directly on or near the root zone of the seedling.Type: ApplicationFiled: December 20, 2011Publication date: April 19, 2012Inventors: Franklin Paul Silverman, Dale O. Wilson, JR., Jennifer C. Kochan, Nicole Higgs, Peter D. Petracek, Prem Warrior, Karen S. Arthur