Abstract: A powder aerosol composition is disclosed which includes a powder, a liquefied propellant gas selected from liquefied petroleum gases and liquefied natural gases, and a nonionic surfactant which is substantially insoluble in the liquefied propellant gas.

Abstract: Mixtures of polyglycerol fatty esters obtainable by partial esterification of a polyglycerol mixture consisting offrom 0 to 5% by weight of monoglycerol,from 15 to 40% by weight of diglycerol,from 30 to 55% by weight of triglycerol,from 10 to 25% by weight of tetraglycerol,from 0 to 15% by weight of pentaglycerol,from 0 to 10% by weight of hexaglycerol andfrom 0 to 5% by weight of higher polyglycerolswith one or more saturated fatty acids of 12 to 22 carbon atoms or one or more unsaturated fatty acids of 16 to 22 carbon atoms, where the unsaturated fatty acid or fatty acid mixture used may furthermore contain up to 10% by weight of saturated fatty acids of 16 to 22 carbon atoms and the degree of esterification of the saturated or unsaturated fatty acids in the mixture is from 20 to 70%, are used as emulsifiers in cosmetic and pharmaceutical formulations.

Abstract: Ambiphilic creams with improved spreading and penetration properties as well as improved tolerance contain a glycerol-monostearate-free water-in-oil emulsifier and glycerol and/or sorbitol. Ambiphilic creams with an isopropyl myristate content have particularly favorable properties.

Abstract: A novel anti-sunburn skin-care preparation, such as creams, foundations, milky lotions and the like, is proposed which contains, as the ultraviolet-absorbing and -shielding ingredient, a salt of ellagic acid with a polyvalent metal, e.g., calcium, barium and magnesium. The skin-care preparation is free from the problem of irritation and sensitization of human skin and exhibits excellent anti-sunburn effect with durability.

Abstract: A pharmaceutical composition suitable for oral administration comprises micronized progesterone in an oil vehicle which is high in glycerides of polyunsaturated fatty acids. Micronized progesterone particles suspended in such an oil vehicle are absorbed more readily into the bloodstream and achieve high progesterone blood serum levels. The pharmaceutical composition according to the invention can be readily formulated into capsules and administered for the treatment of premenstrual syndrome.

Abstract: A novel endermic medicament having a consistency of a gel is proposed which is formulated, as a gel base, with non-ionic water-soluble cellulose ether, e.g., methyl cellulose and hydroxypropyl methyl cellulose, modified with a modification agent containing, in the molecule, an alkyl group having 6 to 26 carbon atoms and a functional group having reactivity with the hydroxyl group in the cellulose ether, e.g., stearyl glycidyl ether, decyl glycidyl ether and cetyl epoxide. The endermic medicament formulated with the modified cellulose ether is stable by virtue of the very little interaction between the active ingredients and the gel base and also can exhibit high percutaneous absorptivity of the active ingredients through the human skin.

Abstract: The following diacylglycerin is useful for a cosmetic oil and a cosmetic composition such as pack, cream and emulsion. ##STR1## (where one each of R.sub.1, R.sub.2, and R.sub.3 denotes a residue of a straight-chain saturated fatty acid having 11-17 carbon atoms, a residue of a branched-chain saturated fatty acid having 10-18 carbon atoms, and a hydrogen atom).

Abstract: A pharmaceutical preparation for the percutaneous administration comprises eperisone or tolperisone, including salts thereof, and a monoglyceride of an aliphatic acid having 8 to 12 carbon atoms or/and an ester of lactic acid with an aliphatic alcohol having 12 to 18 carbon atoms. It is improved in the percutaneous absorption.

Abstract: An aqueous solution containing fat-soluble vitamin K is prepared by adding vegetable oil(s), gycerol fatty acid ester(s) or sorbitan fatty acid ester(s) in an amount of 0.004 to 5% by weight, based on the whole aqueous solution, to an aqueous solution containing menatetrenone (vitamin K.sub.2) or phytonadione (vitamin K.sub.1) and hydrogenated lecithin.

Abstract: Cyclosporins are useful immunosuppressive, anti-fungal and antiphlogistic agents which are relatively insoluble in water and aqueous fluids (including body fluids). They may be rendered more soluble or dispersible in aqueous media by first dissolving them in at least one mono- or di- glyceride of a C.sub.6 -C.sub.10 fatty acid, and the resulting solution can then easily be emulsified in water or an aqueous fluid.

Abstract: There is provided an orally ingestible liquid composition for suspending therein an orally administrable pharmaceutically active composition releasable over an extended period of time comprises triglyceride of a medium chain length alkanoic acid or distilled acetylated monoglycerides, a liquid, high HLB polyglyceryl ester, and colloidal silicon dioxide together with a material soluble or dispersible therein and capable of being insolubilized by a pharmaceutically acceptable polyvalent cation and a solid pharmaceutically acceptable salt containing the cation required therefore. Sustained release compositions based thereon containing pharmaceutically active agents are also disclosed.

Abstract: A biocide composition comprises an effective amount of a biocide and an effective amount of a biocide activator selected from the group consisting of an alkyl phosphate, an alkenyl phosphate, a hydroxyalkyl, phosphate, a polyoxyalkylene alkyl ether phosphate, a salt thereof, a polyoxyalkylene alkenyl ether phosphate, a salt thereof, a polyoxyalkylene hydroxyalkyl ether phosphate and a salt thereof.

Abstract: A process for making a directly-compressible vitamin powder utilizes a conventional spray-dryer. The resulting powder is comprised of a fat-soluble vitamin, a water-soluble carbohydrate, and a gelatin having a bloom number between 30 and 300.

Abstract: The present disclosure relates to an external analgesic solid stick composition for the topical administration of active analgesic agents. The compositions are dimensionally stable solid compositions comprising an external analgesic agent incorporated into a non-reactive hydrophobic wax matrix.

Abstract: A biocide is strengthened in the biocidal effect with a branched guaternary ammonium salt having a group of ##STR1## in which R5 is an alkyl or alkenyl having 4 to 18 carbon atoms and R6 is an alkyl or alkenyl having 2 to 16 carbon atoms.

Abstract: An excipient system containing a drug for peroral administration in the form of an ultrafine aqueous, colloidal suspension of lipid nano-pellets comprised of lipids and a surfactant of which the particle diameters of the nano-pellets range from 50-1,000 nm, preferably from 80-800 nm, the ratio of lipid to surfactant in the lipid nano-pellets ranging from 1:0.1 to 1:2.2, preferably from 1:0.22 to 1:1.2, especially from 1:1 to 1:0.22, and where the lipid nano-pellets are present in the suspension in a concentration of from 1-20% by weight. The lipid nano-pellets can be provided with pharmacologically active substances, making possible improved biological availability upon peroral administration.

Abstract: A composition comprised of non-esterified fatty acids having 14-18 carbon atoms; monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms; lysophosphatidyl choline in which the fatty acid moiety has 14-18 carbon atoms and a drug is disclosed. The composition is useful for the delivery of orally-administered drugs. The composition is also useful as a source of readily absorbable fat. When used in this manner, the composition is comprised of non-esterified fatty acids having 14-18 carbon atoms; monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms; lysophosphatidyl choline in which the fatty acid moiety has 14-18 carbon atoms. A method of making the compositions disclosed is also described.

Abstract: A process for making a stable pharmaceutical preparation of prostaglandin E compounds and/or 15R forms thereof is diclosed.Prostagladin E compounds and 15R forms thereof are know to have useful pharmacological actions even if they are used in a vary small amounts. However, they are extremely unstable and, therefore, considerably difficult in application for routine clinical purposes.In order to remove this difficulty, prostagladin E compounds and 15R forms thereof are formulated into a stable preparation by filling a hard capsule with a solution or a suspension thereof.

Abstract: A substitute for lanolin which comprises 40 to 60% by weight of a mixed ester of about equimolar amounts of a di-fatty acid ester of pentaerythritol and a di-fatty alcohol citrate, 20 to 45% by weight of monoglycerides and diglycerides of oleic acid, 3 to 10% by weight of the monoglycerides and diglycerides of palmitic acid and stearic acid and 3 to 10% by weight of an adduct of 3 to 7 mols of ethylene oxide onto vegetable sterol and compositions in which it is included.

Abstract: A stable aqueous emulsion of perfluorochemical, a phospholipid and a triglyceride of fatty acids has been demonstrated which has enhanced stability, diminished particle size and heightened tolerance by biological systems. The emulsion has utility as an oxygen transport medium, such as artificial blood.

Abstract: Penetration-enhancing pharmaceutical compositions for topical transepidermal and percutaneous application are disclosed which are non-irritating to the skin. These compositions are made up of a safe and effective amount of an active pharmaceutical permeant, including hydrophilic salt forms, contained in a novel penetration-enhancing vehicle comprising, (i) 1-95% w. of a cell-envelope disordering compound selected from the group consisting of oleic acid, oleyl alcohol, glycerol monoleate, glycerol dioleate, glycerol trioleate and mixtures thereof, (ii) 5-75% w., and preferably 5-49% w., of a lower alkanol selected from the group consisting of ethanol, propanol and isopropanol and mixtures thereof and (iii) 0-45% w., and preferably 1-45% w., of an inert diluent which, according to properties of the permeant used, may range from hydrophilic to hydrophobic. Water, polyethylene or polypropylene glycols and mineral oil are exemplary diluents.

Abstract: Novel triglyceride quaternary ammonium compounds are provided according to formula I, ##STR1## in which R is an alkyl group having 10 to 20 carbon atoms, preferably n-dodecyl or n-octadecyl, and A.sup.- is a physiologically acceptable anion, preferably chloride. These compounds are prepared by a process which essentially comprises reacting triglyceryl ricinoleate with chloroacetyl chloride to esterify the hydroxyl groups of the triglyceride and then reacting the product obtained with an alkyldimethylamine of the formula N(CH.sub.3).sub.2 R. The compounds of formula I are useful as additives to skin moisturizing compositions and hair conditioners.

Abstract: A granular pesticide containing a surfactant as a synergist can be prepared by countercurrent spray drying under specified conditions. The obtained granular pesticide exhibits excellent fluidity and storage stability and is excellent in wettability and disintegratability.

Abstract: A suppository base comprises 80 to 99 percent by weight of a lauric-type fat having a hydroxyl value of 20 or smaller and containing glycerides of fatty acids having 8 to 18 carbon atoms as the main component and 1 to 20 percent by weight of diglycerides of fatty acids having 14 to 22 carbon atoms and provides an improvement in the discharging property of a medicine contained therein.

Abstract: A stable, water dispersible petroleum jelly formulation, which is an oil-in-water emulsion, is described which comprises water, petroleum jelly, optional humectant, and emulsifier. The composition is formed by ultrasonically emulsifying the various components which will ultimately form the emulsion.

Abstract: Complete dissolution of a wide range of drugs in chlorofluorocarbon aerosol propellents is achieved by the presence of glycerol phosphatides, preferably phosphatidylcholine.

Abstract: Suppositories containing as the active substance a therapeutically effective amount of ceftriaxone, a pharmaceutically compatible salt thereof or a hydrate of one of these compounds, a stabilizer consisting of a mono-, di- or triglyceride of a C.sub.12 -C.sub.18 -fatty acid or of a mixture of such glycerides, a potentiator consisting of an aliphatic C.sub.2 -C.sub.18 -fatty acid, a mono-, di- or triglyceride of a C.sub.2 -C.sub.12 -fatty acid, a partial ester or complete ester of propylene glycol, polyethylene glycol or a carbohydrate with a C.sub.2 -C.sub.12 -fatty acid, a pharmaceutically compatible ester or ether thereof or of a mixutre of the said potentiators and, if desired, customary therapeutically inert adjuvants for suppositories, and their manufacture are described. These have valuable antimicrobial properties.

Abstract: A pharmaceutical preparation having an active substance of low solubility in water and gastric juices that has an initially liquid carrier system consisting of a hydrophilic component, a hydrophobic component and a solubilizer. The solvent mixture contains 9 to 90 parts by weight of solubilizer and 90 to 5 parts by weight of a hydropholic component, such as polyethylene glykol, 1,2-propylene glykol, 1,3-butanediol, 1,4-butanediol, 1,2-propanediol, glycerol, mannitol, sorbitol or polyoxyethylene polyoxypropylene copolymerisate or mixtures of such substances, and 40 to 1 parts by weight of an oleophilic component, such as natural and/or semisynthetic vegetable or animal oils or synthetic oils, such as neutral oil or waxes. The active substance is dissolved in the carrier system or dispersed in a stable way and for an oral application, is filled into drug capsules made of gelatine.

Abstract: A readily absorbable pharmaceutical composition of pharmacologically active agents, which per se are poorly absorbable, is disclosed which comprises a pharmacologically effective amount of at least one such pharmacologically active agent distributed in a vehicle comprising an absorption-enhancing amount of at least one fatty acid of medium chain length. The preparation is suited for formulating pharmacologically active bases, cardiac glycosides, steroids, antibiotics, sympathicomimetica, tranquilizing agents, or local anaesthetics.

Abstract: Factor VIII:C deficiency in a hemophilic mammal may be bypassed by infusion of a synergistic mixture of a phospholipid and Factor Xa so that the cascade process of blood clotting may continue. The proportions of phospholipid and Factor Xa in the mixture are critical as too little Xa has no effect while too much is toxic (thrombogenic). Infusion of the phosphilipid-Factor Xa mixture into normal mammals enhances the natural clotting rate and provides a method for rapidly controlling bleeding in emergency situations.

Abstract: There are disclosed compounds having the formula ##STR1## wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR.sub.2 where R.sub.2 is loweralkyl, or NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R.sub.1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl; Y is C.dbd.O or CR.sub.5 OH where R.sub.5 is hydrogen or loweralkyl; Z is CH.sub.2 or C.dbd.CR.sub.6 R.sub.7 where R.sub.6 and R.sub.7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR.sub.5 .dbd.CH where CR.sub.

Abstract: A biocide activator is disclosed which is a product prepared by adding propylene oxide, alone or together with ethylene oxide, to a mixture of a fatty acid triglyceride and a polyhydric alcohol under conditions effective to cause addition polymerization. This activator exhibits a remarkable biocide enhancing-effect without harm to various crops when used with existing biocides such as insecticides, fungicides, herbicides and plant growth regulators.

Abstract: A hydrophilic cosmetic product contains a novel randomly polymerized polyglycerol, polytrimethylene- or -tetramethylene-oxide condensate of an 8-36 carbon aliphatic alcohol or fatty acid useful as a non-ionic surface active agent.

Abstract: A composition and body wrap comprising several herbs forms the basis for a solution, salve and an oil which is applied to the body. The body is completely wrapped and covered with a non-porous membrane to retain the body heat. The method of making the solution, salve and oil is described using nutrients such as lecithin, herbs such as kelp, parsley, chickweed, and, alfalfa, and sesame oil and water. A carrier used to keep the solution on the body is a foam or sponge material and the non-porous membrane is a thin plastic material. All of the materials are disposed of after one use.

Abstract: There are disclosed compounds having the formula ##STR1## wherein X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, NHCOR.sub.2 wherein R.sub.2 is loweralkyl, or a group of the formula NR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R and R.sub.1 are independently hydrogen, loweralkyl, phenylloweralkyl, phenylloweralkyl in which the phenyl group is substituted by one or more loweralkyl, loweralkoxy, halogen, hydroxy or trifluoromethyl, diphenylloweralkyl or diphenylloweralkyl in which one or both phenyl groups are substituted by one or more loweralkyl, loweralkoxy, halogen, hydroxy or trifluoromethyl; Y is C.dbd.O or CR.sub.5 OH wherein R.sub.5 is hydrogen or loweralkyl; Z is CH.sub.2 or C.dbd.CR.sub.6 R.sub.7 wherein R.sub.6 and R.sub.7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR.sub.5 .dbd.CH wherein CR.sub.

Abstract: There is provided a fat emulsion of an ester of flurbiprofen having the formula ##STR1## wherein R is a group of the formula ##STR2## wherein R.sub.1 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, R.sub.2 is a C.sub.1 -C.sub.15 alkyl group or a C.sub.2 -C.sub.8 alkenyl group, and m is zero or an integer of 1; or a lactone group of the formula ##STR3## wherein R.sub.3 and R.sub.4 are same as or different from each other and are a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, and n is an integer of 1 or 2.The emulsion containing particles of a vegetable oil dissolving the ester can be orally or parenterally administered to human or animal for analgesia, antiphlogosis and antipyresis in various diseases and exhibits a high activity with small amounts in terms of flurbiprofen as compared with flurbiprofen itself.

Abstract: A composition of matter for controlling Hemophilia A (Antihemophilic Factor (F. VIII:C) deficiency) in mammals is described. Factor VIII:C deficiency in the mammal is bypassed by infusion of a synergistic mixture of a phospholipid and Factor Xa so that the cascade process of blood clotting may continue. The proportions of phospholipid and Factor Xa in the mixture are critical as too little Xa has no effect while too much is toxic (thrombogenic).

Abstract: A thixotropic, spoonable soft gel in an aerated or non-aerated multiphase composition of emulsified glycerides dispersed in a continuous phase of hydrocolloid and has an RVT Brookfield viscosity of about 100,000-500,000 centipoises at room temperature and a TD spindle speed of 2.5 rpm.

Abstract: An externally administrable pharmaceutical which contains an effective amount of 2-(4-isobutylphenyl)propionic acid in a base is obtained by drug dissolution in a mixture of C.sub.6-12 carboxylic acid triglycerides, glycerol monostearate-polyoxyethylene stearate mixture and polyoxyethylene-fatty acid esters. A cream is obtained by stirring this solution with an aqueous phase in the presence of heat.

Abstract: A hair cosmetic composition having a strong gelation-preventive property comprising about 0.1 to about 10% by weight of a certain quaternary ammonium salt, about 0.05 to about 3.0% by weight of a certain 1-hydroxy-2-pyridone salt, about 0.05 to about 20% by weight of a certain polyol derivative, and a cosmetically acceptable carrier.

Abstract: Compositions are disclosed for providing non-greasy, cosmetic moisturizing, conditioning and protective barrier effects on skin and hair, and to a rinse-on method for producing these effects. More particularly the compositions comprise oil-in-water emulsions that are adapted to invert to water-in-oil emulsions at the hair or skin surface when they are rubbed into the skin and hair. The compositions a include water, unctrous oleaginous material, water-dispersible, non-toxic polyvalent metal salt having a cation selected from the group consisting of aluminum (III), cerium (III), iron (III), zirconium (IV), aluminum zirconium coordination complexes, and mixtures thereof and sufficient acid or alkali to provide a pH value of about 1.5 to 7.5.

Abstract: A method for controlling HemophiliaA (Antihemophilic Factor (F. VIII:C) deficiency) in mammals is described. Factor VIII:C deficiency in the mammal is bypassed by infusion of a synergistic mixture of a phospholipid and Factor Xa so that the cascade process of blood clotting may continue. The proportions of phospholipid and Factor Xa in the mixture are critical as too little Xa has no effect while too much is toxic (thrombogenic).

Abstract: An anhydrous or aqueous cosmetic composition contains, as an oily phase, the fat of Shorea robusta or a mixture of the fat of Shorea robusta and a cosmetically acceptable oil, another fat or wax. The cosmetic composition can be a cream, an emulsion or any other composition containing or comprising an oily phase.