Nitrogen Containing Patents (Class 514/788)
  • Patent number: 10124065
    Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: November 13, 2018
    Assignee: Novartis AG
    Inventors: Jeremy Lee Baryza, Rohan Eric John Beckwith, Keith Bowman, Crystal Byers, Tanzina Fazal, Gabriel Grant Gamber, Cameron Chuck-Munn Lee, Ritesh Bhanudasji Tichkule, Chandra Vargeese, Shuangxi Wang, Laura West, Thomas Zabawa, Junping Zhao
  • Patent number: 10016513
    Abstract: The invention encompasses therapeutic formulations comprising a protein active ingredient and a stabilizing excipient, methods of improving stability in a therapeutic formulation comprising a protein active ingredient by adding a stability-improving amount of a stabilizing excipient to the therapeutic formulation, and methods of reducing adverse infusion-related effects in a patient, comprising administering to a patient in need thereof a therapeutic formulation comprising a protein active ingredient and a stabilizing excipient.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: July 10, 2018
    Assignee: Reform Biologics, LLC
    Inventors: David S. Soane, Robert P. Mahoney, Philip Wuthrich, Daniel G. Greene
  • Patent number: 9987297
    Abstract: A method for bonding a polymeric fiber to tissue is provided which includes providing a polymeric fiber having a plurality of tissue reactive members linked to a surface of the fiber via a specific binding pair, and contacting the polymeric fiber to biological tissue, to covalently bond the fiber to the tissue.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: June 5, 2018
    Assignee: Sofradim Production
    Inventor: Sébastien Ladet
  • Patent number: 9371273
    Abstract: Ether-amide compounds having the formula RaRbC(OR1)—CHRc—CONR2R3 are described. Also described, are processes for the preparation and use thereof, especially as solvents, for example in phytosanitary formulations.
    Type: Grant
    Filed: August 26, 2014
    Date of Patent: June 21, 2016
    Assignee: RHODIA OPERATIONS
    Inventors: Massimo Guglieri, Olivier Jentzer
  • Patent number: 9220670
    Abstract: Described are novel monocationic polyhydroxyl compounds and their uses in personal care compositions.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: December 29, 2015
    Assignee: Dow Global Technologies LLC
    Inventors: Joseph L. Deavenport, Nicole A. Brehm
  • Patent number: 9068143
    Abstract: The present invention relates to novel quinazoline compounds and their use in perfume compositions. The novel quinazoline compounds of the present invention are represented by the following formula: an isomer or a mixture of isomers thereof, wherein the broken line represents a single or double bond.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: June 30, 2015
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Michael G. Monteleone, Robert P. Belko, Franc T. Schiet, Paul D. Jones, Anthony T. Levorse, Jr.
  • Patent number: 9040593
    Abstract: The invention relates to a water-insoluble reaction product of an oil-soluble high carbon polar modified polymer and a polyamine.
    Type: Grant
    Filed: December 16, 2009
    Date of Patent: May 26, 2015
    Assignee: L'OREAL
    Inventors: Hy Si Bui, Mohamed Kanji, Chunhua Li, Anita Chon Tong, Susan Halpern, Bruno Bavouzet
  • Publication number: 20150141527
    Abstract: The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.
    Type: Application
    Filed: July 22, 2014
    Publication date: May 21, 2015
    Inventors: Catherine TACHDJIAN, Xiao Qing TANG, Donald S. KARANEWSKY, Guy SERVANT, Xiaodong LI, Feng ZHANG, Qing CHEN, Hong ZHANG, Timothy James DAVIS, Vincent DARMOHUSODO, Melissa WONG, Victor SELCHAU
  • Publication number: 20150141526
    Abstract: The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
    Type: Application
    Filed: November 18, 2014
    Publication date: May 21, 2015
    Applicant: COSMO TECHNOLOGIES LTD.
    Inventors: Luigi MORO, Luigi Maria LONGO, Enrico FRIMONTI, Alessandro REPICI
  • Patent number: 9034355
    Abstract: A polymeric composition capable of releasing nitric oxide and modulating biological responses comprises a biocompatible polymer and S-nitrosated thiol bonded to the biocompatible polymer. The polymeric composition can have a thiol conversion of at least 40%. The polymeric composition can also have a nitric oxide recovery of at least 40% when under thermal decomposition conditions.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: May 19, 2015
    Assignee: Colorado State University Research Foundation
    Inventors: Melissa M. Reynolds, Vinod B. Damodaran
  • Patent number: 9005663
    Abstract: An exemplary embodiment of the invention is a method for making silver nanoparticles, and includes steps of reacting a silver salt with a phosphene amino acid to make silver nanoparticles. Exemplary phosphene amino acids include trimers, with a particular example being a trimeric amino acid conjugate containing one phosphene group. In an exemplary method of the invention, the silver nanoparticles may be produced in timer periods of less than about 30 minutes, and at temperatures of less than about 40° C. Other methods of the invention are directed to methods for stabilizing silver nanoparticles.
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: April 14, 2015
    Assignee: The Curators of the University of Missouri
    Inventors: Kannan Raghuraman, Kattesh K. Katti
  • Publication number: 20150099810
    Abstract: Fragrances that provide a scent of freshness tend to be volatile and are therefore not very economical when used in typical applications such as washing or cleaning processes, so they have to be used in relatively large quantities to be able to produce adequate effects. The disclosed photolabile pro-fragrances provide a much longer-lasting sense of fragrance, in particular with a scent of freshness, when used in typical applications, thus allowing said fragrances to be used economically.
    Type: Application
    Filed: December 15, 2014
    Publication date: April 9, 2015
    Inventors: Thomas Gerke, Christian Kropf, Ursula Huchel, Axel Griesbeck, Agnieszka Landes
  • Patent number: 9000054
    Abstract: The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: April 7, 2015
    Assignee: Senomyx, Inc.
    Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao Qing Tang, Hanghui Liu
  • Publication number: 20150093339
    Abstract: The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers,—savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.
    Type: Application
    Filed: October 8, 2014
    Publication date: April 2, 2015
    Inventors: Catherine TACHDJIAN, Andrew P. PATRON, Sara L. ADAMSKI-WERNER, Farid BAKIR, Qing CHEN, Vincent DARMOHUSODO, Stephen Terrence HOBSON, Xiaodong LI, Ming QI, Daniel H. ROGERS, Marketa RINNOVA, Guy SERVANT, Xiao-Qing TANG, Mark ZOLLER, David WALLACE, Amy XING, Klaus GUBERNATOR
  • Publication number: 20150094383
    Abstract: Synergistic surfactant blends are disclosed. In one aspect, the blend comprises an anionic surfactant and a metathesis-based cationic surfactant comprising a quaternized derivative. The quaternized derivative is a quaternized fatty amine, quaternized fatty amidoamine, imidazoline quat, or esteramine quat made from a metathesis-derived C10-C17 monounsaturated acid or its ester derivative. Also disclosed are synergistic surfactant blends comprising a cationic surfactant and a metathesisbased anionic surfactant comprising a sulfonated derivative. The sulfonated derivative is a fatty ester sulfonate, fatty acid sulfonate, sulfoestolide, fatty amide sulfonate, sulfonated fatty ester alkoxylate, imidazoline quat sulfonate, sulfonated amidoamine oxide, or sulfonated amidoamine betaine. The synergistic blends have a negative value or a reduced interfacial tension (IFT) when compared with an expected IFT value calculated from the individual surfactant components.
    Type: Application
    Filed: April 12, 2013
    Publication date: April 2, 2015
    Inventors: Randal J. Bernhardt, Xue Min Dong
  • Publication number: 20150056139
    Abstract: Provided are functional segregated telodendrimers having, for example, two or three functional segments. The telodendrimers can have one or more crosslinking groups (e.g., reversible photocrosslinking groups). The telodendrimers can aggregate to form nanocarriers. Cargo such as drugs, imaging probes, and other materials may be sequestered in the core of the aggregates via non-covalent or covalent interactions with the telodendrimers. Such nanocarriers may be used in drug delivery applications and imaging applications.
    Type: Application
    Filed: August 21, 2013
    Publication date: February 26, 2015
    Inventors: Juntao Luo, Wenzhe Huang, Yu Shao, Changying Shi
  • Publication number: 20150057375
    Abstract: The present invention is concerned with the use of pyrrolidones selected from the group consisting of N-n-butylpyrrolidone, N-isobutylpyrrolidone, N-t-butylpyrrolidone, N-n-pentylpyrrolidone, N-(methyl-substituted butyl)pyrrolidones, ring-methyl-substituted N-propyl and N-butyl pyrrolidones and N-(methoxypropyl) pyrrolidone as replacement solvents in specific applications wherein N-methylpyrrolidone (NMP), N-ethyl-2-pyrrolidone (NEP), N,N-dimethyl acetamide (DMAc), and/or dimethyl formamide (DMF) is the appropriate solvent to be used. The invention is also concerned with a solvent comprising NMP, NEP, DMAc, or DMF and one or more pyrrolidones selected from said group, as well as a solvent comprising a second solvent, which is a replacement solvent for NMP, NEP, DMAc, or DMF and one or more selected from said group.
    Type: Application
    Filed: January 17, 2013
    Publication date: February 26, 2015
    Applicant: TAMINCO
    Inventors: Bart Vandeputte, Kristof Moonen, Peter Roose
  • Patent number: 8956638
    Abstract: A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine in an aprotic solvent. The resulting poly(amic acid) composition is suitable as a biocompatible material, such as a biomedical implant, implant coating material, tissue scaffold material, controlled release drug delivery vehicle, and cellular growth substrate.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: February 17, 2015
    Assignee: Axcelon Biopolymers Corporation
    Inventors: Wankei Wan, Donna Padavan
  • Patent number: 8957116
    Abstract: To provide a solution for forming a double eyelid which enables extremely easy formation of a natural and ideal double eyelid without giving a displeased feeling or an uncomfortable feeling to a user, and a method for forming a double eyelid using the solution for forming a double eyelid. A solution for forming a double eyelid 1 according to the present invention is formed by dissolving, into a solvent having volatility, a fibrous material which forms a film 1a onto a skin 5a of an eyelid 5 and shrinks with vaporization of the solvent. By applying the solution 1, in a successive-curve form, over an imaginary line I forming a fold 5d of a double eyelid in the eyelid 5 onto which a user want to make a fold and vaporizing the solvent so as to shrink the film 1a, successive concaved groove-like constricted part 5c is formed on the imaginary line I and the fold 5d of a double eyelid along the constricted part 5c is formed.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: February 17, 2015
    Inventors: Naoko Iwagaki, Masayuki Kamagata, Jirou Taniyama
  • Publication number: 20150045455
    Abstract: Methods for preparing a PEG composition by co-precipitation of two or more components to produce a substantially homogenous powder. According to some embodiments, the two or more components are at least and partially soluble in a solvent, and at least one component is a functionalized PEG. Contacting the at least two component with the solvent at least partially dissolves the components which are then co-precipitated. The resulting product is substantially homogenous, unlike product made by other methods. The PEG composition may be co-precipitated with additional compounds, such as a colorant like indocyanine green.
    Type: Application
    Filed: March 15, 2013
    Publication date: February 12, 2015
    Applicant: NEOMEND, INC.
    Inventors: Tina Lanette Mcarthur, Tracy Hutchison, Jon Mckannan, Charles Vaughn Cassingham
  • Publication number: 20150031608
    Abstract: The instant invention is drawn to a hepatocyte targeted composition comprising insulin associated with a lipid construct comprising an amphipathic lipid and an extended amphipathic lipid that targets the construct to a receptor displayed by an hepatocyte. The composition can comprise a mixture of free insulin and insulin associated with the complex. The composition can be modified to protect insulin and the complex from degradation. The invention also includes methods for the manufacture of the composition and loading insulin into the composition and recycling various components of the composition. Methods of treating individuals inflicted with diabetes.
    Type: Application
    Filed: October 10, 2014
    Publication date: January 29, 2015
    Inventors: JOHN R. LAU, W. BLAIR GEHO
  • Publication number: 20150030684
    Abstract: An irrigation resistant bone repair composition including a biocompatible or bioactive bone repair material and a mixture of non-random poly(oxyalkylene) block copolymers is described. Also, methods for treating a bone having a bone gap or a bone defect with the composition including a biocompatible or bioactive bone repair material and a mixture of non-random poly(oxyalkylene) block copolymers are also provided. Also, kits including the irrigation resistant bone repair composition including a biocompatible or bioactive bone repair material and a mixture of non-random poly(oxyalkylene) block copolymers are described.
    Type: Application
    Filed: October 13, 2014
    Publication date: January 29, 2015
    Inventors: Gregory J. Pomrink, Cecilia A. Cao, Zehra Tosun, David M. Gaisser
  • Publication number: 20150024022
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Application
    Filed: October 7, 2014
    Publication date: January 22, 2015
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla, Saumya Banerjee, Timothy Sargeant, Joshua Stopek
  • Publication number: 20150018436
    Abstract: The invention provides new lipopolyamines of spermine type of the general formula I, wherein X is C—N bond or aminopolyethyleneglycolcarboxamide linker or o-hydroxy-alkylcarboxamide linker or ?-hydroxyalkylcarboxamidopolyethyleneglycol-carboxamide linker, and wherein a hydrophobic domain Y is an acyl symmetrically branched in the position C(2) or cholesteryl. The invention further provides a method of preparation of said lipopolyamines and their use for construction of polycationic liposomal drug carriers.
    Type: Application
    Filed: January 14, 2013
    Publication date: January 15, 2015
    Applicants: VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V.V.I., USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.
    Inventors: Lukas Drasar, Miroslav Ledvina, Zina Korvasova, Jaroslav Turanek
  • Patent number: 8932615
    Abstract: Implantable devices formed of or coated with a material that includes a polymer having a non-fouling acrylate or methacrylate polymer are provided. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: January 13, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventor: Stephen D. Pacetti
  • Publication number: 20150011661
    Abstract: The present invention relates to a fast curing compositions comprising a (meth)acrylamide functionalized hydrophilic silicone monomers having a polyether moiety containing a branched linking group. In one embodiment, such compositions are useful for preparing water-absorbing silicone-hydrogel films for contact lens applications. In one embodiment, the (meth)acrylamide monomers disclosed here have a branched linking group on the polyether moiety which makes it possible to produce hydrophilic polyether modified silicone copolymers without the need to separate various by-products including, but not limited to, unreacted, isomerized polyether and associated high molecular weight by-products.
    Type: Application
    Filed: September 22, 2014
    Publication date: January 8, 2015
    Inventors: Anubhav Saxena, Shreedhar Bhat, Senthilkumar Umapathy, Kenrick M. Lewis
  • Publication number: 20150005396
    Abstract: Provided is an oil-in-water emulsion composition which, while having a fresh feel without stickiness when used, has a skin unevenness correction effect and persistence thereof, and provides excellent smoothness, moisture and shininess, and feeling of tension. The oil-in-water emulsion composition is characterized by containing, in a specific ratio: (A) a non-emulsifying cross-linked polymethyl siloxane, which contains (a1) a dimethicone crosspolymer and (a2) a non-emulsifying cross-linked polymethyl siloxane other than a dimethicone crosspolymer; (B) an associative thickener; (C) a polyether-modified silicone; (D) a silicone oil; and (E) water in a specific ratio. The oil-in-water emulsion composition is further characterized in that the mass ratio ((a2)/(a1)) of (a2) the non-emulsifying cross-linked polymethyl siloxane other than a dimethicone crosspolymer to (a1) the dimethicone crosspolymer falls within a range of 0.1 to 2.5.
    Type: Application
    Filed: November 30, 2012
    Publication date: January 1, 2015
    Applicant: SHISEIDO COMPANY, LTD.
    Inventors: Takumi Watanabe, Takayuki Omura
  • Publication number: 20140377176
    Abstract: The present invention is related to silicon nanoparticles, a pharmaceutical composition comprising silicon nanoparticles, a method for synthesis of the silicon nanoparticles and their use for in vivo diagnostics, visualization of drug delivery or staining of cells, biological processes or pathways. The silicon nanoparticles are characterised that they comprise a silicon core of a size of 1 to 10 nm and are terminated with allylamine or poly(allylamine) comprising up to 10 allylamine groups.
    Type: Application
    Filed: December 12, 2012
    Publication date: December 25, 2014
    Inventors: Holger Stephan, Ralf Bergmann, Alexander Ruffani, Luisa DeCola
  • Patent number: 8916613
    Abstract: The invention relates to insecticide mixtures comprising thiodicarb and at least one other known active ingredient from the category of chloronicotinyls, as well as the use of these mixtures to control animal pests.
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: December 23, 2014
    Assignee: Bayer CropScience AG
    Inventors: Wolfram Andersch, Heike Hungenberg, Wolfgang Thielert
  • Publication number: 20140371075
    Abstract: Subject matter of the present invention is an emulsifiable concentrate comprising a water-insoluble pesticide, an amide of the formula (I) R1—C(O)N(R2)2??(I) where R1 is C5-C19-alkyl, and R2 is C1-C4-alkyl, a carbonate, which is ethylene carbonate or propylene carbonate, and a hydrocarbon solvent. A further subject matter is an emulsion obtainable by mixing water with the emulsifiable concentrate; a process for the preparation of the emulsifiable concentrate; and a method for controlling phytopathogenic fungi and/or undesired vegetation and/or undesired attack by insects or mites and/or for regulating the growth of plants, where the concentrate or the emulsion is allowed to act on the respective pests, their environment or on the crop plants to be protected from the respective pests, on the soil and/or on undesired plants and/or on the crop plants and/or their environment.
    Type: Application
    Filed: November 29, 2012
    Publication date: December 18, 2014
    Applicant: BASF SE
    Inventors: Cedric Dieleman, Winfried Mayer, Jürgen Jakob, Nadine Riediger
  • Publication number: 20140371293
    Abstract: The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as an amino-amine or an amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic payload or an antisense payload, such as an RNAi agent).
    Type: Application
    Filed: April 17, 2014
    Publication date: December 18, 2014
    Applicant: Dicerna Pharmaceuticals, Inc.
    Inventors: Bob Dale Brown, Sujit Kumar Basu, David A. Schwartz, Allister Fraser
  • Patent number: 8901347
    Abstract: Disclosed are novel bioabsorbable and biodegradable monomer compounds, bioabsorbable and biodegradable polymers therefrom, and methods of making such monomers and polymers, which are useful in pharmaceutical delivery systems, tissue engineering applications, tissue adhesives products, implantable medical devices, foams and reticulated foams for wound healing and drug delivery, bone hemostats and bone void fillers, adhesion prevention barriers, meshes, filters, stents, medical device coatings, pharmaceutical drug formulations, consumer product and cosmetic and pharmaceutical packaging, apparel, infusion devices, blood collection tubes and devices, other medical tubes, skin care products, and transdermal drug delivery materials.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: December 2, 2014
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S. Bezwada
  • Patent number: 8901101
    Abstract: The present invention provides membrane lytic poly(amido amine) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: December 2, 2014
    Assignee: Sirna Therapeutics, Inc.
    Inventors: Marina Busuek, Rubina G. Parmar, Michael Steven Poslusney, Weimin Wang, J. Michael Williams
  • Patent number: 8901154
    Abstract: A topical insecticide preparation is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The topical insecticide contains a combination of a first pyrethroid insecticide effective for killing fleas, a second pyrethroid insecticide effective for killing ticks, and an insect growth regulator (IGR). The topical insecticide preparation can be packaged together or packaged so that the first and second pyrethroid insecticides are stored separately prior to administration of the insecticide preparation to the animal. The combination of the first and second pyrethroid insecticides with an insect growth regulator results in an insecticide preparation formulated to have enhanced insecticidal activity against fleas and ticks compared to the effectiveness of the first and second insecticides used alone.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: December 2, 2014
    Assignee: Ceva Animal Health LLC
    Inventors: Ian Cottrell, Albert Ahn, Linda Dorneval
  • Publication number: 20140348759
    Abstract: A structured surfactant system with a very high degree of clarity. The system comprises water and a mixture of at least one surfactant having a HLB (Hydrophilic Lipophilic Balance) value of less than 10, and at least one surfactant having an HLB value of 10 or greater. The structured surfactant system forms multilamellar vesicles and has suspending properties without added electrolytes, carbohydrates, or polymeric thickeners. This makes the structured surfactant system particularly useful in personal care compositions.
    Type: Application
    Filed: August 8, 2014
    Publication date: November 27, 2014
    Inventors: John Hawkins, Emilie Pace, Laetitia Lebert
  • Publication number: 20140335034
    Abstract: A consumer product comprises silane-modified oil comprising a hydrocarbon chain selected from the group consisting of: a saturated oil, an unsaturated oil, and mixtures thereof; and at least one hydrolysable silyl group covalently bonded to the hydrocarbon chain. The consumer product further comprises a preservative.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Rajan Keshav PANANDIKER, Beth Ann SCHUBERT, John August WOS, Luke Andrew ZANNONI, Nathan Ray Whitely
  • Patent number: 8883767
    Abstract: A low ether gel composition for application to skin comprising a keratolytic agent, in particular salicylic acid, and comprising a nitrocellulose and one or more volatile ingredients, which forms a film on contact with skin adequate to form a protective barrier for the keratolytic agent for a period of time necessary to provide treatment to the skin; methods of treating using such compositions, and dispensers containing such compositions.
    Type: Grant
    Filed: October 4, 2010
    Date of Patent: November 11, 2014
    Assignee: MSD Consumer Care, Inc.
    Inventors: Gerald R. Dever, Eric Chen-nan Su, William Scott Rogersr, Robert C. Johnson
  • Patent number: 8883185
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: November 11, 2014
    Assignee: Covidien LP
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla, Saumya Banerjee, Timothy Sargeant, Joshua Stopek
  • Publication number: 20140329916
    Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.
    Type: Application
    Filed: December 16, 2013
    Publication date: November 6, 2014
    Applicant: Genomatica, Inc.
    Inventors: Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
  • Patent number: 8877729
    Abstract: This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: November 4, 2014
    Assignee: Marina Biotech, Inc.
    Inventors: Steven C. Quay, Michael E. Houston, Jr., Pierrot Harvie, Roger C. Adami, Renata Fam, Mary G. Prieve, Kathy L. Fosnaugh, Shaguna Seth
  • Patent number: 8877234
    Abstract: The invention relates to clear, liquid preservatives, which contain a) one or several 1-hydroxy-4-methyl-6-alkyl-2(1H)-pyridones and/or one or several salts thereof, wherein alkyl represents a linear, branched or cyclic alkyl group having 1-12 carbon atoms, and b) one or several alcohols containing one or several aromatic groups.
    Type: Grant
    Filed: January 25, 2006
    Date of Patent: November 4, 2014
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Waltraud Simsch, {dot over (P)}eter Klug, Sonja Klein
  • Patent number: 8865634
    Abstract: The present invention primarily concerns certain 4-alkyl pyridines of the following formula (I), wherein R is C8-C12 alkyl, odiferous substance mixtures and aromatic substance mixtures containing these 4-alkyl pyridines, the respective uses thereof as an odiferous or aromatic substance (mixture) and corresponding perfumed products.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: October 21, 2014
    Assignee: Symrise AG
    Inventor: Heiko Oertling
  • Publication number: 20140308304
    Abstract: The present invention relates to novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
    Type: Application
    Filed: December 7, 2012
    Publication date: October 16, 2014
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, Akin Akinc, Shigeo Matsuda, Martin Maier
  • Publication number: 20140308360
    Abstract: The invention provides multivalent surface-crosslinked micelle (SCM) particles, crosslinked reverse micelle (CRM) particles, and methods of making and using them. The SCM particles can be used, for example, to inhibit a virus or bacteria from binding to a host cell. The inhibition can be used in therapy for the flu, cancer, or AIDS. The CRM particles can be used, for example, to prepare metal nanoparticles or metal alloy nanoparticles, or they can be used in catalytic reactions.
    Type: Application
    Filed: June 26, 2014
    Publication date: October 16, 2014
    Inventor: Yan Zhao
  • Patent number: 8853283
    Abstract: The invention relates to enantiomerically pure DOTAP chloride and stable crystal modifications of (2R,S)-, (2S)- and (2R)-DOTAP chloride, to a process for the preparation of these modifications, and to the use thereof as constituent for the preparation of medicaments.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: October 7, 2014
    Assignee: Merck Patent GmbH
    Inventors: Michael Platscher, Alfred Hedinger
  • Publication number: 20140296354
    Abstract: Described herein are the one-pot synthesis and characterization of a library of low molecular weight peptoid compounds that are able to form gels at room temperature. The compounds are synthesized from biologically-based starting materials, are biocompatible, and are resistant to degradation by proteases and peptidases.
    Type: Application
    Filed: April 1, 2014
    Publication date: October 2, 2014
    Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
    Inventors: Guijun WANG, Hari P. R. MANGUNURU
  • Patent number: 8841382
    Abstract: The present invention provides an amphiphile of the formula (I) as described hereinafter. The invention further relates to a process for preparing the amphiphile and to a composition comprising the amphiphile and a sparingly water-soluble active ingredient. It further relates to a process for producing the composition by contacting the amphiphile and the active ingredient, and to the use of the amphiphile for solubilizing a sparingly water-soluble active ingredient in aqueous solutions. The invention also relates to the use of the amphiphile in an agrochemical formulation comprising the amphiphile and a pesticide for controlling phytopathogenic fungi and/or unwanted vegetation and/or unwanted insect or mite infestation and/or for regulating the growth of plants, and finally to plant propagation material comprising the amphiphile.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: September 23, 2014
    Assignee: BASF SE
    Inventors: Anna Cristadoro, Holger Türk, Michael Ishaque, Rabie Al-Hellani
  • Publication number: 20140271956
    Abstract: The present invention relates to a lamellar structure which stabilizes oil and to a cleansing composition comprising the lamellar structure. More particularly, the present invention relates to a lamellar structure, which stabilizes oil to be used in a cleansing composition so that high-content oil is converted to a lamellar phase and contained in a composition. The present invention also relates to a cleansing composition which comprises the lamellar structure which enables the composition to contain high-content oil in a stable manner and to thus provide superior moisturizing ability.
    Type: Application
    Filed: October 8, 2012
    Publication date: September 18, 2014
    Inventors: Chang Jo Jung, Dae Kyeong Kim, John Hwan Lee, Wang Gi Kim
  • Publication number: 20140255373
    Abstract: The present invention relates to an alpha-alkoxysilane-terminated prepolymer preparable by reaction of at least one polyether polyol, of a polyisocyanate and of an alpha-alkoxysilane having at least one isocyanate-reactive group, said polyether polyol having a weight average of 500 to 7000 g/mol and having ethylene oxide and propylene oxide units, the proportion of ethylene oxide units being up to 50% by weight based on the polyether polyol. The invention further provides a process for preparing an inventive alpha-alkoxysilane-terminated prepolymer, a composition, a multicomponent system and a spray can comprising an inventive alpha-alkoxysilane-terminated prepolymer, and also a moulding obtainable by polymerization from an inventive alpha-alkoxysilane-terminated prepolymer.
    Type: Application
    Filed: September 25, 2012
    Publication date: September 11, 2014
    Applicant: Bayer Intellectual Property GmbH
    Inventor: Jan Schönberger
  • Publication number: 20140242123
    Abstract: The disclosure provides for saccharide-peptide based hydrogels, the functionalization of the saccharide-peptide based hydrogels with one or more biological agents, and the encapsulation of one or more biological materials and/or pharmaceutical agents in the hydrogels. The disclosure further provides for the use of the saccharide-peptide based hydrogels in treating a disease or disorder in a subject.
    Type: Application
    Filed: February 21, 2014
    Publication date: August 28, 2014
    Inventors: Zhibin Guan, Yoko Mullen, Sophia W. Liao