Abstract: Modified ceramides are defined, together with their synthesis and compositions comprising them for topical application to human skin, hair and nails. The modified pseudoceramides have a structure: ##STR1## and an approximate summary is that R and R.sup.1 are aliphatic hydrocarbon, A is CH.sub.2, CHOR.sup.2, CH.dbd.CH or CHOY, and at least one of R.sup.2, R.sup.3 and R.sup.4 is sulphate, phosphate or similar. The presence of phosphate or sulphate facilitates skin absorption, after which the phosphate or sulphate is removed by enzymes present in vivo.

Abstract: An anti-peroxide external preparation for skin comprising: decomposition product of shell membrane: and tocopherol and/or derivatives thereof. It is possible to suppress formation of peroxide and remove it.

Abstract: A silicone polymer, a paste-like silicone composition prepared by kneading the silicone polymer and a silicone oil under a shearing force, and a water-in-oil type cosmetic composition comprising the paste-like silicone composition as an oil phase component are disclosed. The silicone polymer is prepared by the addition polymerization of components comprising an organohydrogenpolysiloxane R.sup.1.sub.a R.sup.2.sub.b H.sub.c SiO.sub.(4-a-b-c)/2 (1) or R.sup.1.sub.f H.sub.g SiO.sub.(4-f-g)/2 (2) and a polyoxyalkylene C.sub.m H.sub.2m-1 O(C.sub.2 H.sub.4 O).sub.h (C.sub.3 H.sub.6 O).sub.i C.sub.m H.sub.2m-l (A) or an organopolysiloxane R.sup.1.sub.j R.sup.4.sub.k SiO.sub.(4-j-k)/2 (B) the components, including (1) or (A) as an essential component. The silicone polymer can swell in silicone oils and function as a viscosity increasing agent for silicone oils.

Abstract: Cosmetically elegant anhydrous foaming creams contain high levels of glycerin and emollients, sodium cocoyl isethionate at levels of 19% or less and an effective amount of a detergent additive to increase the softness of the composition. The detergent additive is preferably one of the following: sodium lauryl sulfate, a sodium salt of fatty acid taurate, an acyl glutamate, an .alpha.-olefin sulfonate or a neutralized lauryl phosphoric acid. The detergent additive can be present in an amount from about 1 to about 20 weight percent.

Abstract: A method is provided for improving skin condition through a system whose steps include applying to the skin separately on a plurality of days a first composition that incorporates a retinoid which is either retinol or retinoic acid in a pharmaceutically acceptable carrier. Once the skin has acclimated to any irritation induced by the first composition, a second composition is applied to the skin daily for a subsequent period of time. The second composition will also include retinoid but at a level at least about 10% higher than that employed in the first composition. Once the skin has acclimated to the second composition, subsequent progressive increases of the active retinoid can be applied over subsequent periods of time. Finally, a maintenance level composition is utilized with the highest level of retinoid in the progressive program to minimize potential irritation.

Abstract: A personal care composition is provided, comprising (A) an effective amount of a polyalkylsiloxane copolymer having a melting point of from about -40.degree. to about +40.degree. C., and being selected from various specific polyalkylsiloxane copolymer fluids or polyalkylsiloxane copolymer resins; and (B) a cosmetically acceptable carrier medium, wherein the polyalkylsiloxane copolymer contains mixtures of linear lower alkyl side chains and linear higher alkyl side chains or mixtures of linear alkyl side chains and branched alkyl side chains. The polyalkylsiloxane copolymers used in the composition are fluids or soft waxes at body temperature and have improved application and payout and better substantivity and hair conditioning properties.

Abstract: A skin cream composition according to the present invention provides significant retexturization of the skin, producing significantly improved smoothness, as well as significantly minimizing age spots and improving color of the skin, together with increasing the firmness and moisture content of the skin. The composition can comprise: water, and emulsified and dispersed in the water: (1) sodium lactate; (2) a micellar complex comprising horse chestnut extract, Crataegus extract, water, panthenol, propylene glycol, phospholipids, phenoxyethanol, glycosphingolipids, chlorphenesin, and cholesterol; (3) a protein complex comprising serum proteins, hydrolyzed animal proteins, and glycogen; (4) a carbohydrate-based complex comprising dextran, glycine, and glucosamine; (5) a long-chain fatty acid ester of retinol; (6) a long-chain fatty acid ester of ascorbic acid; and (7) a short-chain fatty acid ester of tocopherol.

Abstract: Disclosed are photoprotective compositions comprising a radical scavenging agent and an anti-inflammatory agent which are useful for topical application to prevent damage to skin caused by acute or chronic UV exposure. Combinations of a radical scavenging agent, an anti-inflammatory agent, and a sunscreen are also disclosed.Also disclosed is a method for using these compositions topically to prevent damage to skin caused by acute or chronic UV exposure.

Abstract: Free radical deactivating 4- or 1,4-substituted, 2,2,6,6-tetramethyl piperidines are condensed with UV absorbing cinnamic acids or benzoic acids or benzoazols or benzophenones to produce skin anti-aging compounds and compositions which have both free radical deactivation and UV absorbing properties.

Abstract: This invention relates to alkylmethylsiloxanes mixtures which are useful for softening and moisturizing skin. The mixtures comprise one or more alkylmethylsiloxane solvents of the structure [MeRSiO].sub.a [Me.sub.2 SiO].sub.b or R'Me.sub.2 SiO(MeRSiO).sub.w (Me.sub.2 SiO).sub.x SiR'Me.sub.2 and one or more alkylmethylsiloxane waxes of the structure R'Me.sub.2 SiO(Me.sub.2 SiO).sub.y (MeRSiO).sub.z SiMe.sub.2 R', wherein each R is independently a hydrocarbon of 6 to 30 carbon atoms, R' is methyl or R, a is 1-6, b is 0-5, w is 0-5 and x is 0-5, provided a+b is 3-6 and w is not 0 if R' is methyl.

Abstract: A water-in-oil type emulsified solid composition containing (a) an oil component such as a silicone oil, (b) a solid wax and/or an oil-gelling agent, (c) water, and (d) (i) a polyoxyalkylene modified organopolysiloxane or (ii) a lipophilic surfactant and a hydrophobically treated powder, wherein the water content is 5% by weight or more, based upon the total amount of the composition.

Abstract: The improved cleansing cream has a wrinkle-reducing effect when periodically applied to and rubbed into the human skin in wrinkled skin areas. The cream is non-irritating to the skin and includes a plurality of water-soluble granules which are of sufficient size, quantity and hardness to abrade the keratinized outer epidermal layer of the skin. The granules may be one or more inorganic salt, but preferably include one or more water-soluble vitamins and/or water-soluble vitamin-yielding salts, The cream also includes a base in which the granules are substantially uniformly disposed. The base preferably is in a major proportion with respect to the granules and is an oil and a petrolatum jelly. The water-soluble granules do not clog the pores of the skin but are absorbed into and nourish the skin.

Abstract: A skin care composition contains an antioxidant effective amount of a phenolic diterpene compound of the ferruginol type. The compounds can be dissolved, dispersed or encapsulated in cosmetic solutions, lotions, creams and liposomes to provide skin care products which reduce the accumulation of lipid peroxides and other biological oxidation products in the skin. Such compositions are effective agents against the production of peroxides in the skin resulting from sunlight, heat, radiation and the aging process.

Abstract: The invention relates to alkylglycoside sulfosuccinates of the general formula (1) defined herein, useful in cosmetic preparations.

Abstract: A cosmetic composition is provided having exceptional emulsion stability. The composition includes water, petroleum jelly, a sterol, a phosphatide and a C.sub.16 -C.sub.22 alkanoic triglyceride.

Abstract: Compositions are disclosed for protecting keratin-containing substances in the body, e.g. skin, nails and especially hair, from damage and for helping to restore the damaged keratinous material to a healthy state. In one embodiment the compositions will comprise a liquid fatty acid vehicle containing at least a long chain alkane for bonding hydrophobically to keratin.

Abstract: This invention relates to methods for delipidation of skin or hair through the use of cyclodextrins and cyclodextrin derivatives such as hydroxypropyl .beta.-cyclodextrin. The invention also relates to cerumen removal methods involving introduction of cyclodextrins to the ear canal, followed by complexation of the cyclodextrin with cerumen components, and removal of the resulting cyclodextrin complexes. The cyclodextrin components are used in a substantially oil-free powdered or aqueous formulation without detergents, soaps, solvents, oils or other lipid-like agents.

Abstract: A cosmetic composition is provided comprising (A) 0.05-30% by weight of an amphiphatic lipid, (B) 0.05-30% by weight of a nonionic surfactant, (C) 1-50% by weight, based on (b), of an ionic surfactant, and (D) 40-99% by weight of an aqueous medium, wherein said composition is transparent or semi-transparent, and wherein the ratio of (A)/[(B)+(C)] is 0.2-10, which is beautifully transparent or semi-transparent, and in which the amphiphatic lipids are stably microdispersed.

Abstract: There is described water-in-oil emulsions containing polysiloxane surface active agents which can be formulated into lotions for use in sunscreens and skin care products.

Abstract: Rationally designed wound cleanser that is physiologically compatible. The wound cleanser comprises a surfactant, an osmotic adjuster, a buffering agent, and water. The composition may also contain a preservative, a sudsing agent, a skin protectant, a pH adjuster, and a stabilizer.

Abstract: The invention relates to synthetic tetrapeptides that contain a peptide blocking group at the amino terminus and an enzyme inhibitor at the carboxy terminus, and their use in the prevention of schistosome parasite infection.

Abstract: Compositions containing 1.alpha.-hydroxyvitamin D homolog compounds in a suitable carrier and methods employing such compositions are disclosed for cosmetic uses in the treatment of various skin conditions such as lack of adequate skin firmness, wrinkles, dermal hydration and sebum secretion. Various formulations of the compositions including creams, lotions and ointments are disclosed for use topically, orally or parenterally in accordance with this invention.

Abstract: A deep-cleaning, topical surfactant in liquid form containing; polyethylene glycol alkylphenol ether containing 9 glycol units, Trypsin; Chymotrypsin; Pepsin; Lactobacillus Acidophilus; Ethanol; Hydrogen Peroxide, Acetic acid; and Deionized water.

Abstract: Disclosed are water based, viscoelastic compositions comprising a mixture of high molecular weights hyaluronic acid salts and water soluble poly(ethylene oxides). Also disclosed are cosmetic formulations including said compositions.

Abstract: Aromatic heterocyclic derivatives have the formula ##STR1## wherein R.sub.1 represents (i)--CH.sub.3, (ii)--CH.sub.2 OH or (iii) ##STR2## wherein R.sub.3 represents hydrogen, --OR.sub.4 wherein R.sub.4 represents hydrogen, alkyl having 1-20 carbon atoms or mono- or polyhydroxyalkyl or R.sub.3 represents ##STR3## wherein r' and r" represent hydrogen, lower alkyl or together form a heterocycle, R.sub.2 represents hydrogen or --CH.sub.3 and Ar represents ##STR4## wherein R.sub.6 is hydrogen or alkyl having 1-10 carbon atoms and R.sub.7 represents alkyl having 4-12 carbon atoms or cycloalkyl, Y is CH or a nitrogen atom and X represents oxygen, sulfur or --N--R.sub.8 when R.sub.8 represents hydrogen, lower alkyl or lower alkoxycarbonyl, with the proviso that (i) when Y is CH and X is oxygen or sulfur Ar is other than C and (ii) when Y is nitrogen and X is oxygen, Ar is other than (C) or (D) in which R.sub.6 is alkyl having 1-4 carbon atoms and R.sub.7 is branched alkyl having 4-12 atoms.

Abstract: The invention relates to novel compositions, in particular personal product compositions containing phosphate ester surfactants in which a portion of the surfactant molecule has a so-called "benefit reagent" function. It is believed that this benefit reagent portion comes to play when the surfactant is metabolized or hydrolyzed.

Abstract: Therapeutic as well as preventative measures to improve the cosmetic conditions or to alleviate the symptoms of dermatologic disorders with phenyl alpha acyloxyalkanoic acids and derivatives is disclosed. The cosmetic conditions and dermatologic disorders in humans in which the compounds may be useful include brittle or soft nails; abnormally thin skin, mucous membranes or wound; friction blisters; brittle hairs; pruritus; acne; and diseased nails, skin or mucous membranes due to natural or unnatural causes including but not limited to in flammations or infections. The phenyl alpha acyloxyalkanoic acids and derivatives include, for example, diphenyl alpha acetoxyacetic acid, phenyl alpha acetoxyacetic acid, phenyl alpha methyl alpha acetoxyacetic acid and phenyl alpha acetoxypropanoic acid. The compositions containing the active ingredients are also useful for treatment of skin, nails and hair conditions or disorders in domestic animals.

Abstract: This invention provides compositions comprising a physiologically-active agent and a compound having the structural formula ##STR1## wherein X may represent sulfur or two hydrogen atoms; R' is H or a lower alkyl group having 1-4 carbon atoms; m is 2-6; n is 0-18 and R is --CH.sub.3, ##STR2## wherein R" is H or halogen, in an amount effective to enhance the penetration of the physiologically-active agent through the skin or other membrane of the body of an animal.

Abstract: Cosmetically elegant creams contain high levels of glycerine and emollients, sodium cocoyl isethionate at levels of 19% or less and sodium lauryl sulfate at a level of 1 to 5 percent.

Abstract: Compound of formula: ##STR1## in which R.sub.1 is of the formula: ##STR2## and R.sub.2 is a C.sub.8 -C.sub.20 alkoxy or mono- or dialkylamino or is of the formula: ##STR3## where n=0 or 1; R.sub.4 denotes H, OH or C.sub.1 -C.sub.6 alkoxy; R.sub.5 denoted H or COOR.sub.3 and R.sub.3 is a C.sub.4 -C.sub.20 alkyl.Application of these compounds for the protection of the skin and hair against ultraviolet radiation.

Abstract: An antimicrobial, low toxicity, non-irritating composition comprises a blend of several bis-quaternary ammonium compounds coprecipitated with a copolymer of vinylpyrrolidone and an acrylamido or vinyl quaternary ammonium monomer.

Abstract: The subject invention relates to methods for regulating wrinkles in mammalian skin comprising topical application of a lysophosphatidic acid compound having the structure: ##STR1## or a cyclic derivative thereof having the structure: ##STR2## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted, saturated or unsaturated, straight or branched chain alkyl having from 12 to about 23 carbon atoms; each --X-- is independently --O-- or --S--; and --Y-- is --O-- or --CH.sub.2 --.

Abstract: The invention relates to a compound of formula: ##STR1## where R.sub.1 is of the formula: ##STR2## where R.sub.3 represents a linear or branched C.sub.1 -C.sub.20 alkyl; R.sub.2 is identical to R.sub.1 or is a halogen or a linear or branched C.sub.1 -C.sub.20 alkoxy or mono- or dialkylamino or is of the formulae (III) or (IV): ##STR3## where R.sub.5 is a linear or branched C.sub.1 -C.sub.20 alkyl and n=0 or 1;R.sub.4 denotes H, OH or C.sub.1 -C.sub.5 alkoxy; ##STR4## Application of these compounds to the protection of the skin and hair against ultraviolet radiation.

Abstract: The invention provides a modified protease such that a protease is coupled to a polysaccharide via a triazine ring. This modified protease is considerably stable, safe and active as compared with the conventional modified proteases and immobilized proteases. Therefore, cosmetic products containing this modified protease are less liable to undergo aging, easier to use and improved in effect on the skin.

Abstract: A urethane derivative from amino acids has the formula ##STR1## wherein R represents --CH.sub.2 OH, --CHOH--CH.sub.3 or --(CH.sub.2).sub.3 --NH--CO--NHY, Y represents --H or --COOR', R' represents linear or branched alkyl, optionally unsaturated, having 8-24 carbon atoms, or a monocyclic cycloalkyl substituted by an alkyl whose total number of carbon atoms is equal to or greater than 10, or to the salts of the derivative of formula I or to a mixture of the derivatives of formula I and/or their salts. A method is given for the preparation of the urethane derivative of formula I, as are examples of cosmetic or pharmaceutical compositions containing the urethane derivative, as a hydrating agent, for the treatment of dry skin.

Abstract: This invention relates to a nonionic cold mix emulsion and preparation thereof. More particularly, the present invention relates to a cosmetic composition in the form of a cream preparation which comprises a discontinuous phase dispersed in a continuous phase. The continuous phase contains water, an emulsifier, and at least one oxidizing agent. The discontinuous phase contains salts of fatty acid esters of lactylic acid, saturated monoglycerides and propylene glycol monoesters. The emulsions are particularly suitable as components of oxidizing preparations for the bleaching of hair and for the dying of hair with oxidation hair dyes and hair bleaches.

Abstract: An antimicrobial, low toxicity blend composition of several bis-quaternary ammonium compounds of defined structure, and in defined amounts of the composition, and polyvinylpyrrolidone, is described herein.

Abstract: This invention refers to cosmetic compositions, particularly a skin treating preparation, comprising a transparent oil phase and a transparent aqueous phase, preferably with humectant effect, which permits a homogeneous mixture when being shaken, and which separates again in two transparent phases thereafter. These properties are achieved by the addition of 0.1 to 1.0% by weight of a C.sub.12 -C.sub.18 fatty acid triglycerol ester.

Abstract: Lipophilic amphoteric surface active compositions exhibiting remarkable W/O emulsifying property and good stabililty against oxidation, comprising betaines having the general formula ##STR1## wherein R.sub.1 --CO is an acyl radical of estolides, R.sub.2 is an alkylene group having 1 to 3 carbon atoms and n is an integer from 1 to 3.

Abstract: A cosmetic composition comprises in solution in an appropriate vehicle at least one polymer having 50-100% of repeating units of the .beta.-alanine type having the formula ##STR1## and 0-50% of repeating units of the acrylamide type having the formula ##STR2## wherein R.sub.1 represents hydrogen or a member selected fromthe group consisting of (i) ##STR3## (ii) --CH.sub.2 OH, (iii) --(CH.sub.2).sub.n --CH.sub.3 wherein n is 0 or a whole number from1 to 11, (iv) ##STR4## wherein r' and r" each independently represent hydrogen or alkyl having 1-3 carbon atoms, (v) --CHOH--COOH, (vi) --CH.sub.2 --SO.sub.3 Na,(vii) ##STR5## and (viii) --(CH.sub.2 --CH.sub.2 --O).sub.m H wherein m ranges from 1 to 10, and R.sub.2 and R.sub.3 represent hydrogen or methyl.

Abstract: Disclosed are a bath lotion and a body lotion both consisting essentially of a fermented liquid of high polymer complex polysaccharides. The fermented liquid is obtained by activating and heat-treating a xanthane gum with microorganisms for carbohydrate fermentation. The bath lotion and body lotion are effective and advantageous to health and have a pharmaceutical effect.

Abstract: A quaternized polymer for use as a cosmetic agent, has recurring units of the formula ##STR1## wherein R is lower alkyl or --CH.sub.2 --CH.sub.2 OH;R' is an aliphatic, alicyclic or arylaliphatic radical containing a maximum of 20 carbon atoms, or R and R' together with the nitrogen atom to which they are attached form a heterocycle capable of containing a heteroatom other than nitrogen;A is a divalent group selected from ##STR2## wherein x, y and t are whole numbers ranging from 0 to 11 such that the sum (x+y+t) is greater than or equal to 0 and lower than 18, and E and K represent hydrogen or an aliphatic radical having less than 18 carbon atoms,--(CH.sub.2).sub.n --S--(CH.sub.2).sub.n --, (3)--(CH.sub.2).sub.n --O--(CH.sub.2).sub.n --, (4)--(CH.sub.2).sub.n --S--S--(CH.sub.2).sub.n --, (5)--(CH.sub.2).sub.n --SO--(CH.sub.2).sub.n --, (6)--(CH.sub.2).sub.n --SO.sub.2 --(CH.sub.2).sub.

Abstract: A novel composition of a hydrolyzed protein together with a surfactant produces a proteinaceous film on the skin to retard moisture loss in cosmetic and toiletry products, such as after shaves, and cleansing lotions. The products retard moisture loss from the skin matrix, but the primary cleansing functions of the products, i.e., removing excess moisture and oil, are not inhibited.

Abstract: Stable diphase emulsions consisting of:a) perfluoropolyethers having perfluoroalkyl end groups;b) a conventional surfactant,dispersed inc) a continuous dispersing phase consisting of glycerol or of a polyhydroxylated compound containing at least three hydroxyl groups, selected from polyalcohols and saccharides, dissolved in a hydrophile solvent and/or water.

Abstract: Compounds of the formula ##STR1## wherein A is selected from the group consisting of (1) phenyl, (2) naphthyl, (3) phenyl substituted with one or more halo, cyano, (C.sub.1 -C.sub.4)alkyl, nitro, (C.sub.1 -C.sub.4)haloalkyl, and (C.sub.1 -C.sub.4)thioalkyl, (4) naphthyl substituted with one or more halo, cyano, (C.sub.1 -C.sub.4) alkyl, nitro, (C.sub.1 -C.sub.4)haloalkyl, and (C.sub.1 -C.sub.4)thioalkyl, (5) thiophene, (6) furan, (7) thiophene substituted with one or more substituents selected from halo and nitro, and (8) furan substituted with one or more substituents selected from halo and nitro;R is selected from the group consisting of hydrogen, (C.sub.1 -C.sub.4)alkyl and substituted or unsubstituted phenyl wherein the substituents are selected from one or more halo, cyano, (C.sub.1 -C.sub.4)alkyl, nitro, (C.sub.1 -C.sub.4) haloalkyl, and (C.sub.1 -C.sub.4)thioalkyl andR.sup.1 is selected from the group consisting of (C.sub.1 -C.sub.

Abstract: A cleansing composition suitable for topical application to human skin to remove make-up, the composition comprising:A. a surfactant system comprising:i) a water-dispersible anionic alkali metal C.sub.10 -C.sub.18 alkylether carboxylate; andii) a water-dispersible nonionic partially esterified polyol; andB. an oil substance chosen from hydrocarbons, esters of a higher alcohol and a higher fatty acid, fatty alcohols, fatty acids, triglycerides, oils or fats of animal and vegetable origin, cholesterol fatty acid esters, perfume oils and mixtures thereof.

Abstract: A novel glycoside, 4.sup.G -alpha-D-glucopyranosyl rutin, is formed by a saccharide-transferring enzyme and glucoamylase in a solution which contains rutin together with glucoamylase. The 4.sup.G -alpha-D-glucopyranosyl rutin formed in such a solution is purified with a synthetic macroreticular resin, and crystallization in an organic solvent yields a complex crystal with the organic solvent. 4.sup.G -Alpha-D-glucopyranosyl rutin exhibits the same molecular absorption coefficient as intact rutin, and is readily water-soluble, substantially tasteless and odorless, and readily hydrolyzable in vivo to exhibit physiological activities inherent to rutin. These render 4.sup.G -alpha-D-glucopyranosyl rutin very useful as a highly-safe, natural yellow coloring agent, antioxidant, stabilizer, quality-improving agent, preventive, remedy, uv-absorbent and deterioration-preventing agent in foods, beverages, tobaccos, cigarets, feeds, pet foods, pharmaceuticals, cosmetics and plastics.

Abstract: A composition suitable for effective and comfortable removal of both waterproof and non-waterproof eye makeup is disclosed which includes an aqueous phase containing at least one surfactant and an oily phase containing at least one cosmetic oil. The surfactant concentration may be up to 3 wt % of the total weight of the composition. The weight ratio of the aqueous phase and the oily phase may be from 30:70 to 60:40.

Abstract: A cosmetic oil and water emulsion is described whose essential components are a polyalphaolefin and a coupling-solubilizing agent of the formula:HO--CH.sub.2 CHRO).sub.m (CH.sub.2).sub.n (OCHRCH.sub.2).sub.m' OHwherein m and m' are integers greater than 1, n is an integer greater than 3; and R is selected from the group consisting of hydrogen, C.sub.1 -C.sub.12 alkyl and mixtures thereof.