Topical Treatment Patents (Class 514/887)
  • Patent number: 4711906
    Abstract: Disclosed are aqueous, stable, relatively concentrated solutions of diclofenac, which contain a mixture of propylene glycol and polyethylene glycol in defined quantitative proportions. The solutions preferably contain a local anesthetic such as lidocaine and a reducing agent as stabilizer.
    Type: Grant
    Filed: December 20, 1985
    Date of Patent: December 8, 1987
    Assignee: Merckle GmbH
    Inventors: Otto von Stetten, Pyare L. Seth, Franz Schmid, Kurt Rauchle
  • Patent number: 4701471
    Abstract: A cosmetic and pharmaceutical composition in the form of non-aqueous antimicrobial creams, lotions, and gels for topical application to the skin comprises bovine bone marrow acids mixed with lecithin for prevention of the fatty acid oxidation and odor putrefaction. The preparation of this product is accomplished without the use or incorporation of any inorganic chemicals, petroleum products, additional water. The heat treated solution provides relief for dry, flaky, and itchy skin and particularly for non-specific dermatitis and rashes.
    Type: Grant
    Filed: April 16, 1986
    Date of Patent: October 20, 1987
    Inventors: Joseph Loucks, Sr., deceased, by Joseph Loucks, Jr., executor
  • Patent number: 4699930
    Abstract: The present invention is a cosmetic composition that raffinose ester of higher fatty acid having carbon atoms from 14 to 20 and cane sugar fatty acid ester are used in parallel, further solcoseryl is compounded to the above. The composition according to the present invention are stable and do not give the irritation on the skin, has no variable nature and has an excellent moisture retaining ability, and then can give the cosmetics which the feeling obtained by employing said cosmetics is very satisfactory. Further the solcoseryl that the substance which deoxyribonucleic acid is dissolved in the raffinose ester of higher fatty acid is added under the sterile condition can be compounded in this cosmetic composition.
    Type: Grant
    Filed: August 14, 1985
    Date of Patent: October 13, 1987
    Inventor: Kazuo Suga
  • Patent number: 4699778
    Abstract: Improved cosmetic compositions for skin care containing an amount sufficient for skin care of glycoprotein extracts of lysed microbial bodies of Hafnia species or strains prepared by (a) cultivating a microbial Hafnia strain until complete development of microbial bodies, (b) subjecting the microbial bodies to lysis, (c) treating the lysate with at least one solvent for delipidation and depigmentation of the lysate, (d) dissolving the resulting product, (e) subjecting the solution to centrifugation and (f) optionally subjecting the resulting product to ultrafiltration and a method of improving a person's skin.
    Type: Grant
    Filed: April 23, 1985
    Date of Patent: October 13, 1987
    Assignee: Roussel Uclaf
    Inventor: Jean-Pierre Marty
  • Patent number: 4678663
    Abstract: A new and improved vehicle for delivering pharmaceutical ingredients to the human skin in a manner whereby the bioavailability, subcutaneous adsorption, and effectiveness of the active ingredient are remarkably enhanced. The vehicle comprises a volatile silicone, a fatty alcohol having from 12-22 carbon atoms, a preselected active ingredient; and such preservatives or emulsifying agents as may be warranted.
    Type: Grant
    Filed: February 6, 1984
    Date of Patent: July 7, 1987
    Assignee: Nuetrogena Corporation
    Inventors: Richard A. Scott, Mitchell S. Wortzman, Eric Jungermann
  • Patent number: 4672074
    Abstract: An ointment containing Indole or an Indole derivative such as Indomethacin and a base; and a process for treating inflammations and lesions on the human skin including the step of applying an ointment containing such an ingredient to the sore.
    Type: Grant
    Filed: January 16, 1985
    Date of Patent: June 9, 1987
    Inventor: Alfred J. Harendza-Harinxma
  • Patent number: 4659573
    Abstract: This invention relates to a substitute for mineral oil in toiletry and cosmetics. In particular it relates to blends of esters which match the viscosity and feel of mineral oil. Specifically, it relates to ester blends which include tridecyl trimellitate.Tridecyl trimellitate ("TDTM") is the ester of tridecyl alcohol and trimellitic acid, and has recently been offered for use to the cosmetics industry.It has surprisingly been found that by blending tridecyl trimellitate with other esters, the viscosity and feel of mineral oil can be matched, the resulting product being a substitute for mineral oil in toiletry and cosmetic compositions.
    Type: Grant
    Filed: February 14, 1985
    Date of Patent: April 21, 1987
    Assignee: Lipo Chemicals, Inc.
    Inventors: Louis B. Frischling, Stephen M. Greenberg
  • Patent number: 4623667
    Abstract: Method and pharmaceutical composition for topically treating skin inflammatory disorders by administering to the inflamed area a therapeutically effective amount of a substantially non-polar hydrocarbon fraction from beeswax comprising a mixture of (i) a major proportion of saturated straight chain C.sub.21 -C.sub.33 hydrocarbons and (ii) a minor proportion of mono-unsaturated long chain hydrocarbons.
    Type: Grant
    Filed: June 28, 1985
    Date of Patent: November 18, 1986
    Assignee: Richardson-Vicks Inc.
    Inventors: Eugene Gans, Sergio Nacht, David Yeung
  • Patent number: 4603219
    Abstract: The compounds 9-(1,3-dihydroxy-2-propoxymethyl)guanine and the pharmaceutically acceptable salts thereof are useful as antiviral agents. The compound 1,3-dibenzyloxy-2-acetyloxy-methoxypropane is useful as an intermediate for the preparation of 9-(1,3-dihydroxy-2-propoxymethyl)guanine.
    Type: Grant
    Filed: October 29, 1984
    Date of Patent: July 29, 1986
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Julien P. H. Verheyden, John C. Martin
  • Patent number: 4593046
    Abstract: There is provided a dermatological composition for treating acne and similar skin lesions which comprises benzoyl peroxide and gel from the plant Aloe vera. The gel from Aloe vera helps to reduce specific undesirable reactions which would otherwise result from the use of benzoyl peroxide to treat skin lesions.
    Type: Grant
    Filed: July 15, 1983
    Date of Patent: June 3, 1986
    Inventor: Murray Gruber
  • Patent number: 4581226
    Abstract: A method of treating various sensitive animal body tissues comprising applying to the tissue a solution prepared from specially processed seawater. The solution is prepared by filtering off-shore seawater to remove debris in small organisms, sterilizing the filtered solution and diluting thereafter with tap water or distilled water to lower the solution's osmolality to about 280 mOs, which renders the solution compatible and isotonic with the tissue to be treated.
    Type: Grant
    Filed: May 24, 1985
    Date of Patent: April 8, 1986
    Inventor: Richard S. Dillon
  • Patent number: 4557754
    Abstract: A novel compound bis-(N,N-dimethyl-N-carbodecyloxymethyl-N-ethyleneammonium)-sulphide dichloride of the formula ##STR1## A method for preparing said novel compound comprising quaternization of bis-(.beta.-dimethylaminoethyl)-sulphide with monochloroacetic acid decyl ester, molar ratio of said reagents being not more than 1:2.A chemotherapeutic antimicrobial preparation comprising said novel compound as an active principle in combination with a pharmaceutical carrier.A plant growth regulator in the form of an aqueous solution of said novel compound in a concentration of from 0.0001 to 0.1 wt. %.
    Type: Grant
    Filed: August 13, 1980
    Date of Patent: December 10, 1985
    Assignee: Institut Organicheskoi Khimii
    Inventors: Georgy A. Golik, Yaroslav P. Demchenko, Miron O. Lozinsky, Vladlen V. Malovik, Valery Y. Semeny
  • Patent number: 4548950
    Abstract: The present invention provides a pharmaceutical composition in the form of a water-containing cream which contains at least one glycyrrhetinic acid derivative (as hereinbefore defined), together with at least one non-toxic, water-soluble salt of zinc, calcium and/or magnesium as stabilizer.
    Type: Grant
    Filed: June 6, 1983
    Date of Patent: October 22, 1985
    Assignee: Biorex Laboratories Limited
    Inventors: Lily Baxendale, Siegfried Gottfried
  • Patent number: 4540572
    Abstract: In addition to indometacin, the gel-like ointment for the topical treatment of inflammation contains a water-soluble cellulose ether or/and a polyacrylic acid, the carboxyl groups of which are neutralized by a water-soluble amine, plus water and ethanol or isopropanol; the components are present in the ratio of amounts suitable for forming a gel. Determination of the level of indometacin in the serum of humans has shown that the absorption through the skin of the active compound from the new ointment is significantly higher than that from the most closely related products.
    Type: Grant
    Filed: December 29, 1983
    Date of Patent: September 10, 1985
    Assignee: Mepha AG
    Inventor: Pyare Seth