Topical Treatment Patents (Class 514/887)
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Patent number: 4954345Abstract: The present invention is directed to a pharmaceutical preparation for external or transdermal application which comprises a dispersion of liposomes, wherein said liposomes incorporate or enclose an active ingredient.Type: GrantFiled: August 15, 1988Date of Patent: September 4, 1990Assignee: Rohm Pharma GmbHInventor: Joseph Muller
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Patent number: 4950688Abstract: A composition suitable for topical application to human skin comprises, in addition to a suitable vehicle and a perfume, an active ingredient which can control skin barrier functions. The active ingredient is (a) a long chain .omega.-hydroxy fatty acid or a carboxy-substituted derivative, (b) an hydroxy- or epoxy-derivative of an essential fatty acid or an ester formed between (a) and (b). Certain novel compounds of structures (a), (b) and (a)(b) esters are also claimed.Type: GrantFiled: June 16, 1983Date of Patent: August 21, 1990Assignee: Conopco, Inc.Inventors: Paul A. Bowser, Albert Froling, Lammert Heslinga, Udo M. T. Houtsmuller, Diederik H. Nugteren, Hendrik J. J. Pabon, Colin Prottey
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Patent number: 4946868Abstract: The invention concerns compositions with antimicrobial activity.These compositions contain a benzoic acid derivative with the formula: ##STR1## in which: A represents a straight or branched alkyl chain with 3 to 4 carbon atoms,X represents the oxygen atom or a direct bond,R represents hydrogen or an alkyl group with 2 to 6 carbon atoms, possibly substituted by an alcohol function and a salt of such a derivative.Applications: drugs, disinfectants and preservative agents.Type: GrantFiled: August 13, 1984Date of Patent: August 7, 1990Assignee: SanofiInventors: Henri Demarne, Robert Filhol, Madeleine Mosse
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Patent number: 4946832Abstract: Cosmetic Base composition exhibiting therapeutic properties comprising an acyl fatty acid alpha-hydroxy carboxylic acid ester or alkali metal salt thereof, a sucrose fatty acid ester, and a solvent.Type: GrantFiled: July 21, 1988Date of Patent: August 7, 1990Assignee: R.I.T.A. CorporationInventors: Stephen T. Goode, Robert R. Linton, Fred Baiocchi
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Patent number: 4942031Abstract: A composition comprising LYCD together with known topically active useful medicinal agents such as antiwrinkling, antibiotic, anticancer, antifungal, antiinflammatory, antiviral, steroid, and wound healing agents. The LYCD works together with the other active ingredients to achieve a synergistic result more effective than can be obtained from the topical agents individually, and more effective than could be predicted from the mere addition of the known efficacies of the individual ingredients.Type: GrantFiled: August 16, 1989Date of Patent: July 17, 1990Inventor: Robert H. Levin
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Patent number: 4940696Abstract: A benzonaphthalene compound has the formula ##STR1## wherein R.sub.1 represents ##STR2## or (ii) --CH.sub.2 OH; R.sub.6 represents ##STR3## or OR.sub.7 wherein R.sub.7 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl or polyhydroxyalkyl, r' or r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or a residue of an amino acid or a sugar, or together form a heterocycle; R.sub.2 represents hydrogen, alkyl having 1-15 carbon atoms, alkoxy having 1-4 carbon atoms or a cycloaliphatic radical; R.sub.3 represents hydrogen, hydroxy, alkyl having 1-4 carbon atoms, alkoxy having 1-10 carbon atoms, a cycloaliphatic radical, a thiocycloaliphatic radical or --O--Si(CH.sub.3).sub.2 --R.sub.8 wherein R.sub.8 represents lower alkyl; and R.sub.4 and R.sub.5 represent hydrogen, lower alkyl, hydroxy or lower acyloxy.This compound is useful in the topical and systemic treatment of dermatologic diseases and in the treatment of the degeneration of conjunctive tissues.Type: GrantFiled: November 16, 1987Date of Patent: July 10, 1990Assignee: Centre International de Recherches Dermatologioues (CIRD)Inventors: Braham Shroot, Jacques Eustache, Jean-Michel Bernardon
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Patent number: 4938960Abstract: The present invention relates to a method for the treatment and protection of human and animal skin which contains vitamin E in a high dose and, in addition, may optionally further contain vitamin C, vitamin A, vitamins of the B series, blood circulation-promoting agents and/or vasodilators, phospholipids, unsaturated fatty acids and/or emulsifiers.Type: GrantFiled: June 21, 1988Date of Patent: July 3, 1990Inventor: Roshdy Ismail
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Patent number: 4937230Abstract: Methods are disclosed for enhancing the healing of a variety of wounds in horses. The methods generally comprise administering to the wound a therapeutically effective amount of a composition comprising GHL:Cu or a derivative thereof in combination with a physiologically acceptable carrier or diluent.Type: GrantFiled: December 4, 1987Date of Patent: June 26, 1990Assignee: ProCyte CorporationInventor: Loren R. Pickart
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Patent number: 4933177Abstract: A cosmetic composition for the treatment of the hair and skin comprises at least 5 weight percent of pulverized particles of at least one plant. The particles have a granulometry lower than 125 microns. The compositions also includes a cohesion agent in an amount to maintain the homogeneity of the composition.Type: GrantFiled: June 15, 1988Date of Patent: June 12, 1990Assignee: Societe Anonyme dite: L'OREALInventors: Jean-Francois Grollier, Josiane Allec, Chantal Fourcadier, Georges Rosenbaum, Patrick Darmenton
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Patent number: 4931274Abstract: A composition for effectively treating dandruff, seborrheic dermatitis and scalp psoriasis comprising a combination of essential ingredients consisting of microfine particles of a clay mineral containing adsorbed magnesium, water, ethanol, sodium chloride and, optionally, minor amounts of glycerin and precipitated sulfur. The effectiveness of the method in treating such scalp diseases by topical application to the scalp epidermis is predicated on the capacity of the composition to release and deliver magnesium cations and hydroxyl anions to the causative sites and return the associated pathological cells to a normal morphology.Type: GrantFiled: August 17, 1988Date of Patent: June 5, 1990Assignee: Physiological Research AssociatesInventors: William A. Barabino, Robert J. Cross
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Patent number: 4923893Abstract: External preparations consisting essentially of about 0.1% to about 5% of tocopherol acetate and/or about 0.05% to about 0.3% of glycyrrhetinic acid, about 1% to about 15% of a methacrylic acid-ethyl acrylate copolymer, and about 0.2% to about 3% of a thickening agent in an alcoholic solvent, wherein said copolymer is characterized by that the monomer ratio of ethyl acrylate to methacrylic acid is within a range from 75/25 to 95/5, with residual monomer being 50 ppm or less and with practically no surfactants.Type: GrantFiled: November 4, 1988Date of Patent: May 8, 1990Assignee: Shionogi & Co., Ltd.Inventors: Izumi Saitoh, Shigeru Kido, Yoshio Doi, Shohei Egawa
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Patent number: 4921874Abstract: There is described a medicinal bath oil containing about 68-95 percent by weight of one or more physiologically acceptable oil and about 30-5 percent by weight of one or more physiologically acceptable emulsifiers, at least one of which is a fatty alcohol polygolyol ether.Type: GrantFiled: August 17, 1987Date of Patent: May 1, 1990Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Rolf Franke, Peter Schmersahl
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Patent number: 4919934Abstract: Disclosed are wax based cosmetic stick compositions comprising: from about 10% to about 50% of a wax type solidifying agent; and from about 5% to about 90% of a polyalphaolefin. These compositions preferably comprise from about 1.0% to about 40% of an active component, such as a sunscreen agent, analgesic, moisturizing and antiperspirant or a deodorant active.Type: GrantFiled: March 2, 1989Date of Patent: April 24, 1990Assignee: Richardson-Vicks Inc.Inventors: George E. Deckner, Rupali A. Kulkarni
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Patent number: 4920140Abstract: Aromatic heterocyclic derivatives have the formula ##STR1## wherein R.sub.1 represents (i)--CH.sub.3, (ii)--CH.sub.2 OH or (iii) ##STR2## wherein R.sub.3 represents hydrogen, --OR.sub.4 wherein R.sub.4 represents hydrogen, alkyl having 1-20 carbon atoms or mono- or polyhydroxyalkyl or R.sub.3 represents ##STR3## wherein r' and r" represent hydrogen, lower alkyl or together form a heterocycle, R.sub.2 represents hydrogen or --CH.sub.3 and Ar represents ##STR4## wherein R.sub.6 is hydrogen or alkyl having 1-10 carbon atoms and R.sub.7 represents alkyl having 4-12 carbon atoms or cycloalkyl, Y is CH or a nitrogen atom and X represents oxygen, sulfur or --N--R.sub.8 when R.sub.8 represents hydrogen, lower alkyl or lower alkoxycarbonyl, with the proviso that (i) when Y is CH and X is oxygen or sulfur Ar is other than C and (ii) when Y is nitrogen and X is oxygen, Ar is other than (C) or (D) in which R.sub.6 is alkyl having 1-4 carbon atoms and R.sub.7 is branched alkyl having 4-12 atoms.Type: GrantFiled: March 24, 1988Date of Patent: April 24, 1990Assignee: Centre International de Recherches Dermatologiques C.I.R.D.Inventors: Braham Shroot, Jacques Eustache, Jean-Michel Bernardon
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Patent number: 4906658Abstract: Compounds of Formula I ##STR1## the pharmaceutically acceptable salts, and the gamma-lactone form thereof are described. They are antagonists of leukotrienes and SRS-A.Type: GrantFiled: April 21, 1987Date of Patent: March 6, 1990Assignee: Merck Frosst Canada, Inc.Inventors: Haydn W. R. Williams, Robert N. Young
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Patent number: 4898883Abstract: The present invention relates to 1-substituted derivatives of 4-methoxy-2,3,6-trimethylbenzene which are useful in cosmetic or pharmaceutical preparations for use in the treamtnet of dermatological complaints connected with a keratinisation disorder, dermatological complaints having an inflammatory and/or immuno-alleric component or ophthalmological complaints.Type: GrantFiled: July 21, 1987Date of Patent: February 6, 1990Assignee: L'OrealInventors: Gerard Lang, Serge Forestier, Alain Lagrange, Braham Shroot
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Patent number: 4897269Abstract: A method for administering a slightly water soluble biologically active compound by topically applying a pharmaceutical composition containing:(a) lipid vesicles with a biologically active compound captured therein;(b) a saturated solution of the biologically active compound; and(c) the biologically active compound in solid form.Optionally this composition is dispersed in a hydrocolloid gel.Type: GrantFiled: June 27, 1988Date of Patent: January 30, 1990Assignee: Mezei Associates LimitedInventor: Michael Mezei
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Patent number: 4897260Abstract: Glucocorticoid carboxylic acid esters and topical compositions thereof are utilized in methods for modulating cutaneous delayed hypersensitivity. Formulations of the glucocorticoid carboxylic acid esters are disclosed including incorporation into percutaneous drug delivery devices.Type: GrantFiled: February 29, 1988Date of Patent: January 30, 1990Assignee: The Rockefeller UniversityInventors: Peter M. Ross, H. Leon Bradlow
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Patent number: 4897308Abstract: A mixture of at least two aqueous dispersions of non-ionic lipid spherules encapsulating an aqueous phase containing an active substance. The active substance encapsulated in the spherules of one of the dispersions is different from the active substance encapsulated in the spherules of another of the dispersions.Type: GrantFiled: June 8, 1988Date of Patent: January 30, 1990Assignee: L'OrealInventors: Guy Vanlerberghe, Rose-Marie Handjani nee Villa
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Patent number: 4894222Abstract: A skin protective composition for topical application to mammalian skin for protection from water washing containing C.sub.18 -C.sub.36 aliphatic wax and anhydrous starch as its principal active waterproofing agents disposed in a water-free carrier.Type: GrantFiled: April 4, 1988Date of Patent: January 16, 1990Assignee: Neutrogena CorporationInventor: Peter Matravers
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Patent number: 4891208Abstract: Steroidal liposomes comprising a bioactive agent and method for their administration are disclosed, the bilayers of said steroidal liposomes comprising a salt form of a carboxylic acid derivative of a sterol, a salt form of a polycarboxylic acid derivative of a sterol, a salt form of a hydroxy carboxylic acid derivative of a sterol, a salt form of an amino acid derivative of a sterol or a salt form of a poly (amino acid) derivative of a sterol; or a salt form of an organic acid derivative of cholesterol, a vitamin D, a phytosterol, or a steroidal hormone.Type: GrantFiled: September 10, 1985Date of Patent: January 2, 1990Assignee: The Liposome Company, Inc.Inventors: Andrew S. Janoff, Mircea C. Popescu, Alan L. Weiner, Lois E. Bolscak, Paul A. Tremblay, Christine E. Swenson
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Patent number: 4885309Abstract: The compound 6-acetyl-7-[5-(4-acetyl-3-hydroxy-2-propylphenoxy)pentyloxy]-3,4-dihydro-2 4-1-benzopyran-2-carboxylic acid, as well as its enantiomers, salts and lower alkyl esters, are useful in topically administrable dosage forms for the treatment of leukotriene-mediated dermal inflammations, such as psoriasis. These compounds can be formulated into creams, ointments, lotions, gels and other types of compositions suitable for applying on the skin.Type: GrantFiled: August 1, 1986Date of Patent: December 5, 1989Assignee: Hoffmann-La Roche Inc.Inventor: Ann F. Welton
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Patent number: 4885157Abstract: Provided is a cosmetic compositiom which beautifies and moisturizes the skin of a human being. The composition may also have therapeutic effects on the human skin such as the removal of lines or wrinkles, dissolution of fat pockets, the removal of bags under the eyes, and the closing of pores or gaps in the skin to render a smooth uniform appearance. The composition is comprised of seven basic ingredients, which include:live yeat cells,selenium,carotene,RNA,DNA,water andalbumen.These core ingredients generally make up from about 80% to 100% of the composition used in the treatment, and are the basis for the advantages realized thereby. Significant and long-lasting results are particularly achieved upon application of the composition to the human skin with exposure to sunlight.Type: GrantFiled: February 13, 1987Date of Patent: December 5, 1989Inventor: Mary G. Fiaschetti
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Patent number: 4877781Abstract: A hemorrhoidal treatment compound includes pharmaceutically effective amounts of a hydrocortisone compound, pramoxine hydrogen chloride, and ephedrine sulfate. The compound may further contain witch hazel, glycerin, vitamin A, and propylene glycol. The compound is provided in a disposable application kit that includes an absorbent pad with the improved compound absorbed therein for use as a swab or compress. The absorbent pad is further sealed in a wrapping, all of which may be disposed of after a single use.Type: GrantFiled: September 30, 1987Date of Patent: October 31, 1989Assignee: Peter G. LaHayeInventors: Peter G. LaHaye, John A. Selling
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Patent number: 4870010Abstract: Personal care products comprising bioemulsifiers, for example, those produced by Acinetobacter calcoaceticus, are provided. Use of such personal care products result in beneficial effects to skin and hair.Type: GrantFiled: April 15, 1986Date of Patent: September 26, 1989Assignee: Petroleum Fermentations N.V.Inventor: Michael E. Hayes
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Patent number: 4868219Abstract: Noninfectious inflammatory skin diseases in which bacteria or yeasts play a significant adjunctive role are treated with topical formulations of aliphatic amines containing 9 to 18 carbon atoms, and pharmaceutically acceptable salts thereof.Type: GrantFiled: April 7, 1988Date of Patent: September 19, 1989Inventor: Carl R. Thornfeldt
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Patent number: 4847283Abstract: An ointment containing Indole or an Indole derivative such as Indican or Indomethacin as the active ingredient and a base. Also, a process for treating inflammations and lesions on the human skin including the step of applying an ointment containing the ointment to the lesion.Type: GrantFiled: June 9, 1987Date of Patent: July 11, 1989Inventor: Alfred J. Harendza-Harinxma
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Patent number: 4847257Abstract: 5-Amino or substituted amino 1,2,3-triazoles are disclosed as a new class of antiproliferative agents useful in the treating and managing of psoriasis, inflammatory bowel syndrome, cutaneous leishmanilisis and certain types of cancer.Type: GrantFiled: August 20, 1987Date of Patent: July 11, 1989Assignee: Merck & Co., Inc.Inventors: Donald Hupe, Lawrence Argenbright, Nancy Behrens, Barbara A. Azzolina
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Patent number: 4839159Abstract: The present invention provides a composition comprising L-carnitine in a suitable vehicle for topical application in an effective amount. The present compositions are useful in improving or healing skin conditions including wrinkling, dry or peeling skin, and burns (particularly sunburn), and in healing and prevention of scar formation, particlarly that caused by infection by a pathogen. Treatment methods are also provided.Type: GrantFiled: February 8, 1988Date of Patent: June 13, 1989Assignee: Topicarn, Inc.Inventors: Susan C. Winter, Stefan Szabo-Aczel
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Patent number: 4834980Abstract: Compositions for the transdermal delivery of azatadine and the use of such compositions in the treatment of allergic reactions are disclosed.Type: GrantFiled: September 28, 1987Date of Patent: May 30, 1989Assignee: Schering CorporationInventor: Joel A. Sequeira
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Patent number: 4831023Abstract: Anhydrous vehicles for topical use, e.g. for use with topically active pharmaceutical agents, including antibiotics, anti-fungal agents, anti-inflammatory agents, antihistamines, antipruritics and local anesthetics, comprise principally from about 60 to about 90% by weight of at least one glycol solvent and from about 2 to about 20% by weight etherified saturated fatty alcohol having a total chain length of from 20 to 216 carbon atoms. The vehicles are substantially free of water, greasy substances and fatty alcohols having less than 16 carbon atoms. The vehicles have a cream-like consistency and can also incorporate suitable compatible plasticizers, coupling agents, penetrants and the like.Type: GrantFiled: June 27, 1986Date of Patent: May 16, 1989Assignee: Thames Pharmacal Co., Inc.Inventors: David Garlen, Vivek Desai
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Patent number: 4822601Abstract: Cosmetic Base composition exhibiting therapeutic properties includes an acyl fatty acid lactylate ester or alkali metal salt thereof, a sucrose fatty acid ester, and a solvent.Type: GrantFiled: March 13, 1987Date of Patent: April 18, 1989Assignee: R.I.T.A. CorporationInventors: Stephen T. Goode, Robert R. Linton, Fred Baiocchi
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Patent number: 4818521Abstract: An emulsion cosmetic stably containing vitamin C which comprises a mixture of L-ascorbic acid or a fatty acid ester thereof and an oil, and conventional ingredients for the emulsion cosmetic.Type: GrantFiled: November 24, 1986Date of Patent: April 4, 1989Assignee: Sunstar Kabushiki KaishaInventor: Hiroshi Tamabuchi
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Patent number: 4816254Abstract: The invention provides an ointment composition for treating skin irritations such as diaper rash and decubitus. The composition includes zinc oxide, boric acid, karaya gum, peruvian balsam, cod liver oil and an appropriate solvent and pharmaceutical carrier.Type: GrantFiled: July 29, 1987Date of Patent: March 28, 1989Inventor: Thomas D. Moss
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Patent number: 4808592Abstract: The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or --C(O)R, where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, anti-inflammatory agents, anti-tumor agents, anti-viral agents, and anti-psoriatic agents.Type: GrantFiled: September 4, 1987Date of Patent: February 28, 1989Assignee: Syntex (U.S.A.) Inc.Inventors: Peter H. Nelson, Chee-Liang L. Gu, Anthony C. Allison, Elsie M. Eugui, William A. Lee
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Patent number: 4808610Abstract: Disclosed is an elegant, stable, self-preserving cream formulation containing mometasone furoate, 9.alpha., 21-dichloro-16.alpha.-methyl-1,4-pregnadiene-11.beta.,17.alpha.-diol-3,20- dione-17-(2'-furoate), useful as a topical anti-inflammatory product.Type: GrantFiled: October 2, 1986Date of Patent: February 28, 1989Assignee: Schering CorporationInventors: Farah J. Munayyer, Joel A. Sequeira
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Patent number: 4806523Abstract: Inflammation, acute and/or chronic, is treated with a CIF (TGF-.beta.). The CIF may be administered locally or symstemically, depending upon the indication, and does not require coadministraion of activator or cofactor for efficacy.Type: GrantFiled: March 6, 1986Date of Patent: February 21, 1989Assignee: Collagen CorporationInventors: Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
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Patent number: 4803066Abstract: Pharmaceutical compositions which are suitable for topical application in the treatment of bacterial and/or fungal infections are described. The compositions comprise a synergistic mixture of a silver compound and an azole derivative together with a pharmaceutically acceptable carrier therefor. The compositions may be applied topically in the treatment of burns ulcers and other skin lesions, general skin infections and also in the treatment of infections of the mucous membranes. Preferred compositions contain silver sulphadiazine and clotrimazole or metronidazole. The compositions may be applied as ointments, gels, pessaries, tablets and the like.Type: GrantFiled: March 19, 1987Date of Patent: February 7, 1989Assignee: Smith & Nephew Associated Companies p.l.c.Inventor: Linda M. Edwards
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Patent number: 4772471Abstract: A dispersion in a continuous phase or spherules comprises arranged molecular layers of a non-ionic lipid compound encapsulating an aqueous phase wherein the non-ionic lipid compound has a lipophile group/hydrophile group ratio such that the non-ionic lipid compound swells in the aqueous phase to be encapsulated therein so as to form a lamellar phase. The hydrophile group of the non-ionic compound is selected from the group consisting of polyoxyethylene groups, polyglycerol groups and esters of polyols. The spherules have a diameter between 1,000 .ANG. and 50,000 .ANG..Type: GrantFiled: December 12, 1979Date of Patent: September 20, 1988Assignee: Societe Anonyme dite: L'OrealInventors: Guy Vanlerberghe, Rose-Marie Handjani
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Patent number: 4766148Abstract: Biphenylylpropionic acid derivatives of the formula: ##STR1## wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula: ##STR2## wherein R.sup.1 is a lower alkyl group having 1 to 5 carbon atoms and R.sup.2 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, or a lactone having the formula: ##STR3## wherein R.sup.3 and R.sup.4 are hydrogen atom or a lower alkyl group having 1 to 2 carbon atoms, and n is an integer of 1 or 2. The compounds have excellent anti-inflammatory, analgesic and antipyretic activities. Moreover, the compounds have no irritation, rapid and long-acting, and high safety margin.Type: GrantFiled: June 7, 1985Date of Patent: August 23, 1988Assignee: Kaken Pharmaceutical Co., Ltd.Inventors: Katsuhiro Uchida, Shozo Masumoto, Masao Tohno, Mitsuo Mimura, Makoto Okumura
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Patent number: 4764361Abstract: The invention includes novel pharmaceutical compositions for topical use in the therapy or prophylaxis of inflammatory skin diseases, a method of treating one or more such diseases, a novel, optically active N-substituted-isobutyramide as an active ingredient and a process for the manufacture of said novel active ingredient.Type: GrantFiled: March 11, 1987Date of Patent: August 16, 1988Assignee: Imperial Chemical Industries PLCInventors: Andrew J. T. Bilski, Ralph Howe, Balbir Rao, David S. Thomson
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Patent number: 4761288Abstract: The present invention provides a novel multiphase drug delivery system which comprises:(a) lipid vesicles with a biologically active compound captured therein;(b) a saturated solution of the biologically active compound; and(c) the biologically active compound in solid form.Optionally this composition is dispersed in a hydrocolloid gel.Type: GrantFiled: September 10, 1985Date of Patent: August 2, 1988Assignee: Mezei Associates LimitedInventor: Michael Mezei
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Patent number: 4760095Abstract: Fatty acid esters of .alpha.-tocopherol and mixtures thereof which provide a moisturizing composition for topical application and their use in cosmetic preparations.Type: GrantFiled: January 28, 1986Date of Patent: July 26, 1988Assignee: Hoffmann-La Roche, Inc.Inventors: David Djerassi, Errol S. Schnurman
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Patent number: 4760051Abstract: A method of enhancing the wound-healing process in animals utilizing glycyl-1-histidyl-1-lysine: copper(II) (GHL-Cu) is disclosed. GHL-Cu functions as a superoxide dismutase which detoxifies tissue-damaging oxygen radicals, but does not evoke an antigenic response. A method of treating inflammatory conditions in animals and a method of reducing the traumatic effects in animals occurring subsequent to major tissue damage utilizing GHL-Cu is also disclosed.Type: GrantFiled: January 24, 1985Date of Patent: July 26, 1988Inventor: Loren R. Pickart
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Patent number: 4743442Abstract: Skin care composition containing mineral salts releasing sodium, potassium, megnesium, calcium and zinc salts in defined concentration, and, optionally, compounds releasing copper, manganese, vanadium, aluminum, cobalt and/or iron ions.Type: GrantFiled: November 27, 1985Date of Patent: May 10, 1988Assignee: Blendax-Werke R. Schneider GmbH & Co.Inventors: Helmut Raaf, Rudolf Bimczok, Ingrid Ittel
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Patent number: 4734434Abstract: A method for the relief of pruritus comprising the administration of an effective antipruritic amount of a N-(trifluoromethylphenyl)anthranilic acid ester to an afflicted patient.Type: GrantFiled: March 11, 1986Date of Patent: March 29, 1988Assignee: Rorer Pharmaceutical CorporationInventors: Robert L. Procaccini, Kim D. Lamon, Nicholas S. Hagen
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Patent number: 4721612Abstract: Methods and compositions are described for the preparation of lipid vesicles, the bilayers of which comprise a salt form of an organic acid derivative of a sterol such as the tris-salt form of a sterol hemisuccinate. The method is rapid, efficient, and does not require the use of organic solvents. The sterol hemisuccinate vesicles may be used to entrap compounds which are insoluble in aqueous solutions. Such preparations are especially useful for entrapping bioactive agents of limited solubility thus enabling administration in vivo.Type: GrantFiled: April 10, 1985Date of Patent: January 26, 1988Assignee: The Liposome Company, Inc.Inventors: Andrew S. Janoff, Mircea C. Popescu, Alan L. Weiner, Lois E. Bolcsak, Paul S. Tremblay
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Patent number: 4720353Abstract: A stable water-in-oil emulsion composition for topical therapeutic administration comprising:a. a dispersed aqueous phase comprising water optionally containing a pharmaceutically acceptable electrolyte dissolved therein;b. a pharmaceutically acceptable continuous oil phase comprising mineral oil and a volatile silicone fluid;c. an organopolysiloxane emulsifier of Formula (I) hereinafter described;d. PPG-20 Methyl Glucose Ether Distearate; ande. an active drug component for topical application.Type: GrantFiled: April 14, 1987Date of Patent: January 19, 1988Assignee: Richardson-Vicks Inc.Inventor: Stephen R. Bell
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Patent number: 4714615Abstract: Method for retexturizing and smoothening the skin comprising topically applying to the skin a composition comprising from about 1.5 to about 2.5 parts by weight of a powdery, cosmetically acceptable inorganic material, such as calcium carbonate, and about 1 part by weight of nerve tissue such as the spinal cord.Type: GrantFiled: April 11, 1986Date of Patent: December 22, 1987Inventor: Rina Youssefyeh
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Patent number: 4713394Abstract: Dermatoses involving nonacne inflammatory dermatoses, infectious cutaneous diseases, and hair loss resulting from inflammation or hormonal anomalies are treated with dicarboxylic acids containing 7 to 13 carbon atoms, or certain mercapto derivatives or salts thereof.Type: GrantFiled: June 11, 1986Date of Patent: December 15, 1987Inventor: Carl R. Thornfeldt