Topical Treatment Patents (Class 514/887)
  • Patent number: 5166139
    Abstract: Complexes of saponins from Centella asiatica, terminalia sp. and Terminalia sericea and relevant aglycons with phospholipids are described. The saponins may be asiaticoside, madecassicoside and sericoside. The molar ratio of phospholipids to saponins is from 0.5 to 2. The phospholipids are selected from the group consisting of soy lecithins, phospholipids from bovine or swine brain or cutis, phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine in which the acyl groups can be the same or different and are mostly derived from palmitic, stearic, oleic, linoleic, linolenic acids. Pharmaceutical compositions and the method of treatment are also described.
    Type: Grant
    Filed: January 18, 1991
    Date of Patent: November 24, 1992
    Assignee: Indena, S.p.A.
    Inventors: Ezio Bombardelli, Gianfranco Patri, Roberto Pozzi
  • Patent number: 5165932
    Abstract: The invention relates to therapeutical compositions on medical herb basis for the treatment of psoriasis and the preparation of the same. A further object of the invention in the use of medical herbs as listed below in the treatment of psoriasis, rheumatism and asthmatic dyspnoea. The medical herbs used in the invention are as follows:Allium sativum /garlic/,Urtica dioica /common nettle/,Chelidonium majus /milkweed/,Veronica officinalis /veronica/,Calendula officinalis /calendula or marigold/,Achillea herba /millefolium/ /yarrow/,Fumaria officinalis /fumitory, earth-gall/.
    Type: Grant
    Filed: September 15, 1989
    Date of Patent: November 24, 1992
    Assignee: Unipharma Co., Ltd.
    Inventor: Ferenc Horvath
  • Patent number: 5158977
    Abstract: A 5,6,7,8-tetrahydro-1-naphthalenol derivative of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent lower alkyl,R.sub.5 and R.sub.6 represent hydrogen or lower alkyl,R represents hydrogen, C.sub.1 -C.sub.18 alkyl, C.sub.2 -C.sub.18 alkyl substituted by one or more hydroxyl groups, C.sub.3 -C.sub.18 alkenyl, C.sub.2 -C.sub.18 acyl, benzyl, benzoyl, carboxyl and carboxylic salts of an alkali or alkaline earth metal or of an organic amine.The derivative is useful as an antioxidant in cosmetic compositions and in pharmaceutical compositions for the preventive treatment of cutaneous inflammations and allergies or certain forms of cancer.
    Type: Grant
    Filed: June 7, 1991
    Date of Patent: October 27, 1992
    Assignee: L'Oreal
    Inventors: Jean Maignan, Gerard Malle, Andre Deflandre, Gerard Lang
  • Patent number: 5151534
    Abstract: Compounds corresponding to the formula: ##STR1## wherein A represents --(CH.sub.2).sub.2 or --(C.tbd.C)--;n is equal to 0, 1 or 2;R represents hydroxyl, alkoxy having the formula --OR.sub.1, or amino having the formula ##STR2## R.sub.1 represents alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or aralkyl;R.sub.2 and R.sub.3 represent hydrogen, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or benzyl;R.sub.2 and R.sub.3 form, with the nitrogen atom, a heterocyclic ring.Application of these compounds in pharmacy and cosmetics.
    Type: Grant
    Filed: May 10, 1989
    Date of Patent: September 29, 1992
    Assignee: Centre International de Recherches Dermatologiques (CIRD)
    Inventors: Braham Shroot, Christopher Hensby, Jean Maignan, Gerard Lang, Michel Colin
  • Patent number: 5151425
    Abstract: According to the invention, it has been found that plant cytokinins are effective in treating inflammation in mammals, such as humans. The plant cytokinins are effective to treat the inflammation, to accelerate healing of lesions, and to provide substantially immediate relief of pain, itching, and other immunological responses resulting from inflammation. The plant cytokinin is administered to the mammal in a suitable pharmaceutical preparation.Particular plant cytokinins which have been tested include trans-zeatin (trans-6-(4-hydroxy-3-methyl(but-2-enyl)-aminopurine)), 6-benzyl-adenine (6-benzylaminopurine), and kinetin (6-furfurylaminopurine).A composition for topical use in accordance with the method comprises an effective amount of the plant cytokinin in a carrier suitable for topical application to the human skin, for example, hydrophilic ointment, isopropyl alcohol, or a powder formulation.
    Type: Grant
    Filed: June 20, 1991
    Date of Patent: September 29, 1992
    Inventor: LeaLand L. Clark
  • Patent number: 5145679
    Abstract: A topical emollient for the treatment of circulation induced lesions comprises a source of glucose and insulin. The topical emollient is utilized in a process wherein the emollient is applied to the affected surface for nourishment thereof and promotion of healing. The emollient also enhances the therapeutic benefits of other medicinal drugs which may be topically applied in conjunction with the insulin and glucose mixture.
    Type: Grant
    Filed: October 9, 1990
    Date of Patent: September 8, 1992
    Inventor: Joan B. Hinson
  • Patent number: 5141951
    Abstract: Compounds of formula I ##STR1## wherein R.sub.1 is alkyl, alkoxy, alkylthio, alkylamino, aryl, aryloxy, arylthio, arylamino, aralkyl, aralkoxy, aralkylthio or aralkylamino,R.sub.2 and R.sub.3 are each independently hydrogen, halogen, hydroxy, mercapto, nitro or amino or have the meanings given for R.sub.1, andX is --NH.sub.2, --NH--OH, --N(R.sub.4)OH, --NH--NH.sub.2 or --NH--N.dbd.C(R.sub.4)R.sub.5, whereinR.sub.4 and R.sub.5 are each alkyl,in free form or pharmaceutically acceptable salt form, have pharmaceutical utility, in particular in the treatment or prophylaxis of asthma, or in the treatment of inflammation or psoriasis.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: August 25, 1992
    Assignee: Sandoz Ltd.
    Inventor: Hans-Jurg Wuthrich
  • Patent number: 5137718
    Abstract: A composition for a topically applied therapeutic cream or ointment having effective activity against one or a combination of sources of viral, bacterial, yeast and fungus infections characterized by the ability to penetrate beneath the epidermal layer of the skin. The composition includes a water soluble active component which is formulated with a water soluble organic solid base and a water soluble surfactant to form an aqueous solution having a gel-like consistency. A preferred active ingredient is a povidone-iodine complex. A preferred carrier is hydroxyethylcellulose.
    Type: Grant
    Filed: May 15, 1990
    Date of Patent: August 11, 1992
    Assignee: G&S Medical Ltd
    Inventor: C. Edward Gillespie
  • Patent number: 5137923
    Abstract: Lipophilic quaternary ammonium salicylate, characterized in that it corresponds to the formula: ##STR1## in which: (i) R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, denote an alkyl or alkylcycloalkyl radical, optionally substituted or interrupted;(ii) R.sub.3 and/or R.sub.4 denote(s) a group:R.sub.8 --OC.sub.2 H.sub.3 R.sub.7 ].sub.n [OCH.sub.2 CHOH--CH.sub.2 ].sub.pin which: 0.ltoreq.n.ltoreq.4 and p denotes 0 or 1; R.sub.8 denotes H or an alkyl, alkenyl, alkylcycloalkyl or alkylaryl radical;(iii) R.sub.4 denotes an alkylphenyl radical;(iv), (v) R.sub.1 and R.sub.2 can form a saturated or unsaturated aromatic or non-aromatic heterocycle;(vi) R.sub.1, R.sub.2 and R.sub.3 form polycyclic derivatives with the nitrogen atoms; R.sub.5 denotes a group corresponding to the formula: ##STR2## in which n is an integer varying between 0 and 10.
    Type: Grant
    Filed: June 21, 1990
    Date of Patent: August 11, 1992
    Assignee: L'Oreal
    Inventors: Michel Philippe, Henri Sebag, Michel Hocquaux, Bernard Jacquet, Jean P. Laugier
  • Patent number: 5134161
    Abstract: Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 is lower alkoxy or optionally substituted phenoxy,R.sup.2 is the same as R.sup.1, or R.sup.2 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenylalkyl,R.sup.3 is hydrogen, lower alkyl, lower alkoxy, halo, optionally substituted phenyl, optionally substituted phenyl-lower-alkyl or optionally substituted phenyl-lower-alkoxy, and m is 1 or 2;both X groups are the same and X is either --C(O)OR.sup.4 or --C(O)NR.sup.5 R.sup.6, whereinR.sup.4 is alkyl, phenyl or benzyl optionally substituted with one or two lower alkyl groups, lower alkoxy groups or halo; andR.sup.5 and R.sup.6 are independently hydrogen, lower alkyl, cycloalkyl or phenyl optionally substituted with one or two lower alkyl groups, lower alkoxy groups or halo.
    Type: Grant
    Filed: April 15, 1988
    Date of Patent: July 28, 1992
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Michael C. Venuti, John M. Young
  • Patent number: 5126135
    Abstract: The present invention relates to a dermatological composition composed for cosmetics or medicines for external application to skin and to oral or nasal mucous-membrane. This composition can be applied in particular in the cosmetic or pharmaceutical field, especially in the dermatological cases to regenerate and to revitalize damaged cells by equilibrating electrochemical ion gradients across cell membrane and also by osmotic pressure on the inner face of the cell membrane. A composition based on a water phase in accordence with present invention comprises dextran, glucose, mutan lentinan, NaCl, KCl, and CaCl.sub.2, which are dissolved in the aqueous phase.
    Type: Grant
    Filed: June 18, 1991
    Date of Patent: June 30, 1992
    Assignee: Japan Fine Chemical Co., Ltd.
    Inventors: Hajime Yamada, Akira Yamada
  • Patent number: 5126331
    Abstract: Compositions for topical use containing as active ingredients depolymerized deoxyribonucleic acids can be used for the reduction of the unaesthetisms of the face skin, due to the couperose. Said compositions can be advantageously used also to locally reduce, in the lower limbs, the skin unaesthetisms (dilated capillaries, oedemas, tumefactions), resulting from a situation of an extended physical stress acting on the above-mentioned legs.
    Type: Grant
    Filed: August 16, 1990
    Date of Patent: June 30, 1992
    Assignee: Crinos Industria Farmacobiologica S.p.A.
    Inventor: Giovanni Gazzani
  • Patent number: 5126375
    Abstract: Phenethanolamine derivatives are disclosed of formula ##STR1## wherein m is 2 to 8; n is 1 to 7 provided that m+n is 4 to 12;Ar is phenyl or phenyl substituted by one or two halogen atoms, alkyl or alkoxy groups or by an alkylenedioxy group;R.sup.1 and R.sup.2 are hydrogen or alkyl provided that the sum total of carbon atoms in R.sup.1 and R.sup.2 is not more than 4; and the physiologically acceptable salts and solvates thereof.The compounds have a selective stimulant action at .beta..sub.2 -adrenoreceptors and may be used inter alia in the treatment of diseases associated with reversible airways obstructions such as asthma and chronic bronchitis. The compounds may be formulated in conventional manner as pharmaceutical compositions with physiologically acceptable carriers or excipients.The compounds may be prepared, for example by alkylation of an amine: ##STR2## where R.sup.3, R.sup.5 and R.sup.6 is hydrogen or a protecting group, followed by removal of any protecting group.
    Type: Grant
    Filed: November 29, 1990
    Date of Patent: June 30, 1992
    Assignee: Glaxo Group Ltd.
    Inventors: Ian F. Skidmore, Lawrence H. C. Lunts, Harry Finch, Alan Naylor
  • Patent number: 5124320
    Abstract: An external analgesic lotion containing active ingredients of camphor and menthol to relieve pain in muscles, joints, or viscera distal at the site of application by stimulating cutaneous sensory receptors and a method of making such lotion and being made from camphor and menthol crystals.
    Type: Grant
    Filed: February 13, 1991
    Date of Patent: June 23, 1992
    Inventors: Jeffery W. Ivy, Curtis E. Payne
  • Patent number: 5106879
    Abstract: A treatment for inflammatory disorders, such as herpes simplex, eczema, shingles, atopic dermatitis, psoriasis, etc. The treatment includes the topical application of an ointment base containing a small quantity ot triacontanol. The triacontanol-ointment preparation is applied directly to the infected skin area as often as is needed.
    Type: Grant
    Filed: April 8, 1991
    Date of Patent: April 21, 1992
    Inventor: Lealand L. Clark
  • Patent number: 5104657
    Abstract: The invention relates to combination preparations containing chloramphenicol, gentamicin, nystatin and optionally a cortisone as active ingredients for the topical treatment of inflammatory skin disorders. The preparations are present preferably in the form of an ointment and have proved to be surprisingly effective particularly in the case of the treatment of skin disorders which are difficult to heal such as chronic eczema, inflammations in the anal and genital region, and of ulcus cruris and similar disorders.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: April 14, 1992
    Inventor: Souhail Abdulla
  • Patent number: 5104656
    Abstract: To prepare an analgesic, anti-inflammatory cream, ibuprofen-S is dissolved in the PEG-7-glycerylcocoate and propylene glycol by slightly warming the solution to about 40 degrees Centigrade. Fractionated coconut oil, di-isopropyladipate, stearic acid, cetyl alcohol, polyoxyl-40-stearate, sorbitan-monostearate and propylparaben are mixed and heated to 70 degrees Centigrade. Methylparaben Sod. is dissolved in demineralized water and heated to 70 degrees Centigrade. The above oil and water phase components are mixed together, cooled to about 50 degrees Centigrade and the ibuprofen-S solution is added to the emulsion. The emulsion is homogenized and cooled to room temperature to form the cream.
    Type: Grant
    Filed: June 16, 1989
    Date of Patent: April 14, 1992
    Inventors: Pyare L. Seth, Lorne A. Campbell
  • Patent number: 5096697
    Abstract: Cell-stimulating composition having hair-growing effect and skin-vivifying effect. The composition comprising as an effective ingredient an aliphatic alcohol having odd number of carbon atoms or a derivative thereof in a cosmetically acceptable carrier.
    Type: Grant
    Filed: August 23, 1989
    Date of Patent: March 17, 1992
    Assignee: Lion Corporation
    Inventors: Kuniaki Adachi, Hideo Tamai, Masanao Sadai
  • Patent number: 5091182
    Abstract: A dispensing unit for a ketorolac topical gel formulation is disclosed, wherein the dispensing unit comprises a ketorolac topical gel formulation and a gas-impermeable multi-layered container wherein the container is comprised of a polyolefin inner layer and a metal foil outer layer.
    Type: Grant
    Filed: July 23, 1990
    Date of Patent: February 25, 1992
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: John T. H. Ong, Jean S. Fujiki, Wei-Cheng Liaw
  • Patent number: 5087499
    Abstract: The present invention relates to improvements in puncture-resistant and medicinal treatment garments. Garments made from fibers such as KEVLAR.RTM. and designed to deter penetration of objects are subjected to an additional brushing step to enhance the fibers' abilities to prevent penetration of sharp needle-like penetrating objects. The fibers may also be coated with an abrasive material to further engage and deflect penetrating objects. In another aspect of the invention, the fibers may be coated with a disinfectant or pharmaceutical agent. The coated fibers, having the improved fiber structure resulting from the brushing step, may be used in fabrics to treat skin conditions, disinfect penetrating objects in puncture-resistant materials, or as a disinfecting prevention fabric for use in textiles in high risk infection areas such as hospitals and public facilities.
    Type: Grant
    Filed: May 9, 1990
    Date of Patent: February 11, 1992
    Inventor: Thomas M. Sullivan
  • Patent number: 5086050
    Abstract: Salts of azelastine with acetic acid, gluconic acid, lactic acid or malic acid.
    Type: Grant
    Filed: February 8, 1991
    Date of Patent: February 4, 1992
    Assignee: Asta Pharma AG
    Inventors: Helmut Hettche, Reinhard Muckenschnabel, Gerhard Scheffler, Ilona Fleischhauer, Wolfgang Morick
  • Patent number: 5077036
    Abstract: Biocompatible fluorcarbon emulsions having fluorocarbon in concentrations of from 75% weight per volume to 125% weight per volume have small, biocompatible particle size stability through heat sterilization with one emulsifying agent, including phospholipids, in concentrations of from 3% to 7% weight per volume. The single emulsifying agent can be hydrogenated lecithins and synthesized lecithins. Fluorocarbon emulsions having fluorocarbon in concentrations of from 40% weight per volume to 125% weight per volume have stability of partial pressure of oxygen and of partial pressure of carbon dioxide through heat sterilization and storage for extended periods of time after having been oxygenated with dissolved oxygen.
    Type: Grant
    Filed: March 30, 1990
    Date of Patent: December 31, 1991
    Assignee: Alliance Pharmaceutical Corp.
    Inventor: David M. Long, Jr.
  • Patent number: 5071877
    Abstract: A cream or lotion consisting essentially of at least one active ingredient chosen from the alkali metal salts of certain oximes, phenols or polyethylene glycol monoethers, dispersed in a substantially anhydrous state in a base medium comprising of polyethylene glycol(s) which has (have) optionally been at least partially etherified to reduce the free hydroxyl group content thereof. These creams or lotions are effective against chemical warfare agents of both the V and G types, and against mustard gas (H or HD), and are simpler to make than known potassium salt-containing creams, for example those containing a macrocyclic ether and/or inert thickener and potassium phenate. These creams or lotions may be used both for protection and decontamination, and some may be used as personal barrier creams.
    Type: Grant
    Filed: April 11, 1989
    Date of Patent: December 10, 1991
    Inventors: Robert A. B. Bannard, Alfred A. Casselman, J. Garfield Purdon, Celso E. Mendoza
  • Patent number: 5071876
    Abstract: The compounds of this invention are anilides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided that n+m+p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is hydrogen or lower alkyl; and R.sub.4 is phenyl or substituted phenyl. The compounds of the present invention are useful in the treatment of inflammation, allergy and hypersensitivity reactions and other disorders of the immune system.
    Type: Grant
    Filed: July 27, 1990
    Date of Patent: December 10, 1991
    Assignee: G. D. Searle & Co.
    Inventors: Richard A. Mueller, Richard A. Partis, James R. Deason
  • Patent number: 5063060
    Abstract: The invention relates to a method of treating painful, inflammatory or allergic disorders comprising treatment with an effective amount of a composition comprising cis-8-methyl-N-vanillyl-6-nonenamide. The invention also relates to compositions for use in the inventive method.
    Type: Grant
    Filed: December 19, 1989
    Date of Patent: November 5, 1991
    Assignee: Cisco Limited Partnership
    Inventor: Joel E. Bernstein
  • Patent number: 5061491
    Abstract: A medicinal agent for treatment of mastitis in animals and humans which includes a mixture of a decoction of a mixture of the following medicinal herbs in equal parts by weight and an ammonia solution infusion which is a mixture of the same medicinal herbs in equal parts by weight, wherein the medicinal herbs include Matricaria chamomilla L., flores Calendulae officinalis L., Urtica dioica L., Erythreae centaurium Raf. L., gemmae Betula pendula Roth, Plantago major L., gammae Pinus sylvestris L., Origanum vulgare L., Salvia officinalis Hoffm., Archangelica officinalis Hoffm., Taraxacum officinale Web., folium Tussilaginis farfarae L., Sanguisorba officinalis L., Valeriana officinalis L., Menthae piperitae L., Thymus vulgaris L., and Bidens tripartita L. The decoction and infusion are mixed in a ratio to adjust the Ph of the mixture to not below 7.4. Also disclosed is a method of treating mastitis using the medicinal agent described above.
    Type: Grant
    Filed: July 21, 1989
    Date of Patent: October 29, 1991
    Inventor: Alexandr M. Deryabin
  • Patent number: 5061720
    Abstract: Disclosed are novel substituted 4-thiazolidinone derivatives having cyclooxygenase and 5-lipoxygenase inhibiting properties and which are topical antiinflammatory agents for inflammed conditions of the skin having the formula: ##STR1## wherein R is hydrogen or loweralkyl; R.sup.1 is loweralkyl or aryl; X is --(CH.sub.2)-aryl, --O--(CH.sub.2).sub.0-3 -aryl, --C(O)(CH.sub.2).sub.0-3 -aryl, --CH(OH)--(CH.sub.2).sub.0-3 -aryl or 3,4 ##STR2## (to form naphthyl ring); aryl is phenyl, substituted phenyl, or 2,3 or 4 pyridyl; W is oxygen; Q is -(alk.sup.1).sub.0-1 --(O).sub.0-1 --(B).sub.0-1 --(alk.sup.2).sub.0-1 --[C(O)Z].sub.0-1 ; B is ##STR3## Z is OR.sup.3 or NR.sup.4 R.sup.5 where R.sup.3 is hydrogen, loweralkyl, or a pharmaceutically acceptable metal cation, R.sup.4 and R.sup.5 are hydrogen or loweralkyl; alk.sup.1 and alk.sup.
    Type: Grant
    Filed: September 13, 1989
    Date of Patent: October 29, 1991
    Assignee: A. H. Robins Company, Inc.
    Inventors: David A. Walsh, Ibrahim M. Uwaydah
  • Patent number: 5061724
    Abstract: A method of treating inflammations of body joints in humans by topical application of anti-inflammatory agents may be used to treat joints afflicted by arthritic conditions such as gouty arthritis. The steps of the method include dissolving a predetermined quantity of a known anti-inflammatory drug, applying the medium with dissolved anti-inflammatory drug directly onto the skin covering a body joint known to be inflamed and allowing the medium with dissolved anti-inflammatory drug to be absorbed into the skin. Possible non-steroidal, anti-inflammatory drugs which may be used with the method include indomethacin, phenylbutazone and colchicine. Steroidal non-inflammatory drugs may also be used.
    Type: Grant
    Filed: July 18, 1989
    Date of Patent: October 29, 1991
    Inventor: Sheldon Gertner
  • Patent number: 5051438
    Abstract: This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl and m is 1 or 2;R.sup.1 is alkyl of 1 to 4 carbon atoms;R.sup.2 is hydrogen or alkyl of 1 to 5 carbon atoms;R.sup.4 is alkyl of 1 to 6 carbon atoms;n is an integer from 1 to 5; andY is NH or oxygen.The compounds of Formula I are leukotriene B.sub.4 antagonists and are useful as anti-inflammatory agents and in the treatment of LTB.sub.4 mediated diseases.
    Type: Grant
    Filed: May 16, 1990
    Date of Patent: September 24, 1991
    Assignee: G. D. Searle & Co.
    Inventors: Stevan W. Djuric, Thomas D. Penning
  • Patent number: 5047249
    Abstract: This invention relates to activated protein-containing compositions comprising reducing agents, oxidizing agents and/or anti-oxidants and methods of use. The therapeutic compositions and methods of the present invention are particularly effective in promoting wound healing, and in inhibiting certain skin disorders, including eczema and seborrhea, sclerodema and acne. The therapeutic compositions and methods of the present invention have also shown enhanced effect as veterinary tools in reducing the debilitation associated with certain skin conditions in mammals including eczematoid dermatitis, chronic dermatitis, equine exuberant granuloma ("proud flesh"), decubitis ulcers, and canine cutaneous granulomas ("lick" granuloma).
    Type: Grant
    Filed: March 3, 1989
    Date of Patent: September 10, 1991
    Assignee: John Morris Co., Inc.
    Inventors: John Rothman, Philip A. Band
  • Patent number: 5043162
    Abstract: Compositions containing mixtures of lower alkyl nicotinate and histamine hydrochloride, particularly useful in promoting hair growth and revitalizing the hair and scalp by topical application.
    Type: Grant
    Filed: September 5, 1990
    Date of Patent: August 27, 1991
    Inventor: Seymour F. Trager
  • Patent number: 5028428
    Abstract: Compositions and methods for reducing the adverse reaction of skin to chemicals and compositions that contact the skin, e.g., topical cosmetic and pharmaceutical preparations, and to contact physical irritants. The active ingredient of the composition of the invention comprises a hydro-alcoholic extract of Cola nitida.
    Type: Grant
    Filed: August 9, 1988
    Date of Patent: July 2, 1991
    Assignee: Estee Lauder Inc.
    Inventors: Walter P. Smith, Nicholas J. Pelliccione, Kenneth D. Marenus, Daniel H. Maes
  • Patent number: 5021452
    Abstract: There is disclosed a process for improving wound healing, comprising administering ascorbate or derivatives thereof to a wound site at a concentration of at least 20 .mu.mol/L and irradiating the wound site with a low-power laser at a wave length of about 600 nm to about 1100 nm. The process for improving wound healing can be used for the healing of deep, interior wounds with longer wave length radiation and higher energy output radiation. The process can further be used for improving the healing of superficial skin wounds with shorter wave lengths and lower energy output of the low-power laser.
    Type: Grant
    Filed: March 28, 1990
    Date of Patent: June 4, 1991
    Assignee: The Board of Regents of the University of Washington
    Inventors: Robert F. Labbe, Rebecca L. Rettmer
  • Patent number: 5013726
    Abstract: An external analgesic lotion containing active ingredients of methyl salicylate and camphor and menthol to relieve pain in muscles, joints, or viscera distal at the site of application by stimulating cutaneous sensory receptors and a method of making such lotion and being made from camphor and menthol crystals.
    Type: Grant
    Filed: September 12, 1989
    Date of Patent: May 7, 1991
    Inventors: Jeffery W. Ivy, Curtis E. Payne
  • Patent number: 5013545
    Abstract: Aqueous gel compositions incorporate topically active pharmaceutical agents in a non-irritating gel comprising from about 60 to about 90% ethyl alcohol and from about 0.5 to about 30% water together with at least one gelling agent. Optional additives include gel enhancers, gel neutralizers, ultraviolet absorbers, gel clarifying agents, anti-irritants and moisturizers. The gel compositions exhibit good bactericidal and bacteriostatic activity in addition to the pharmaceutical activity of the active topical ingredient. Methods of treating skin areas in mammals requiring topical medication comprise the application of the gel, with or without the incorporation of a topically active ingredient, to the affected skin areas 1 to 5 times daily.
    Type: Grant
    Filed: December 9, 1987
    Date of Patent: May 7, 1991
    Assignee: Thames Pharmacal Co., Inc.
    Inventors: Steven Blackman, Irene Ralske
  • Patent number: 5008240
    Abstract: Inflammation, acute and/or chronic, is treated with a CIF (TGF-.beta.). The CIF may be administered locally or systemically, depending upon the indication, and does not require coadministration or activator or cofactor for efficacy.
    Type: Grant
    Filed: August 9, 1988
    Date of Patent: April 16, 1991
    Assignee: Collagen Corporation
    Inventors: Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Patent number: 5006337
    Abstract: Medicinal and cosmetic compositions for the treatment of skin disorders and for care of dry and/or irritated skin and of dry scalp with dandruff are prepared using brewers' grains extract(s)--especially a brewers' grains extract obtained using liquid or above-critical CO.sub.2 or N.sub.2 O.
    Type: Grant
    Filed: April 14, 1988
    Date of Patent: April 9, 1991
    Assignee: Marbert GmbH
    Inventors: Lothar Motitschke, Hagen Tronnier
  • Patent number: 5002767
    Abstract: The invention relates to a therapeutic composition containing, as the active principle, .alpha.-linolenic acid and an alcohol of vegetable origin, such as a tocopherol or sitosterol. Preferably, the composition contains other fatty acids and is an organic extract of plants, especially of the Resedaceae family.The invention also relates to the plant extracts as novel products.The therapeutic composition is especially useful as an antiinflammatory.
    Type: Grant
    Filed: August 24, 1988
    Date of Patent: March 26, 1991
    Assignee: Laboratories Natura Medica
    Inventor: Jean-Pierre Masse
  • Patent number: 5001156
    Abstract: Lipophilic quaternary ammonium salicylate, characterized in that it corresponds to the formula: ##STR1## in which: (i) R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, denote an alkyl or alkylcycloalkyl radical, optionally substituted or interrupted;(ii) R.sub.3 and/or R.sub.4 denote(s) a group:R.sub.8 [OC.sub.2 H.sub.3 R.sub.7 ].sub.n [OCH.sub.2 CHOH--CH.sub.2 ].sub.pin which 0.ltoreq.n.ltoreq.4 and p denotes 0 or 1; R.sub.8 denotes H or an alkyl, alkenyl, alkylcycloalkyl or alkylaryl radical;(iii) R.sub.4 denotes an alkylphenyl radical;(iv), (v) R.sub.1 and R.sub.2 can form a saturated or unsaturated aromatic or non-aromatic heterocycle;(vi) R.sub.1, R.sub.2 and R.sub.3 form polycyclic derivatives with the nitrogen atoms; R.sub.5 denotes a group corresponding to the formula: ##STR2## in which n is an integer varying between 0 and 10.
    Type: Grant
    Filed: December 1, 1987
    Date of Patent: March 19, 1991
    Assignee: L'Oreal
    Inventors: Michel Philippe, Henri Sebag, Michel Hocquaux, Bernard Jacquet, Jean P. Laugier
  • Patent number: 5001119
    Abstract: Compounds of the formula: ##STR1## are useful as anti-cancer, anti-obesity, anti-diabetic, anti-coronary agents, anti-aging agents, anti-hypolipidemic agents and anti-autoimmune agents.
    Type: Grant
    Filed: November 25, 1987
    Date of Patent: March 19, 1991
    Inventors: Arthur G. Schwartz, Marvin L. Lewbart
  • Patent number: 4999195
    Abstract: Personal care products comprising bioemulsifiers, for example, those produced by Acinetobacter calcoaceticus, are provided. Use of such personal care products result in beneficial effects to skin and hair.
    Type: Grant
    Filed: July 5, 1989
    Date of Patent: March 12, 1991
    Assignee: Emulsan Biotechnologies Inc.
    Inventor: Michael E. Hayes
  • Patent number: 4996193
    Abstract: The present invention provides formulations for the topical application of cyclosporin to skin tissue for treatment of autoimmune, T-cell mediated immune disease, and inflammatory conditions, and for producing prolonged skin allograft survival and wound healing. In addition, methods for the use of said formulations--in tandem with systemic applications of cyclosporin or without same--are suggested. The present invention also suggests alternative formulations and delivery systems for the efficacious treatment of the aforementioned conditions, and further suggests a model with which formulations may be tested.
    Type: Grant
    Filed: March 3, 1989
    Date of Patent: February 26, 1991
    Assignee: The Regents of the University of California
    Inventors: Charles W. Hewitt, Kirby S. Black
  • Patent number: 4994497
    Abstract: A method is provided of avoiding or minimizing inflammation at a painful freshly burned epidermal skin site, which comprises applying on the skin site promptly before the appearance of overt inflammation, an anti-inflammatory composition in homogeneous non-alcoholic aqueous solution form consisting essentially of distilled hamamelis water, magnesium sulfate, and copper sulfate to allow for transdermal absorption of the composition at the skin site for a period sufficient to achieve local relief of inflammatory symptoms.
    Type: Grant
    Filed: October 11, 1989
    Date of Patent: February 19, 1991
    Inventor: Orlyn G. Pepper
  • Patent number: 4994263
    Abstract: A composition for treatment and treatment of certain skin diseases is disclosed. The treatment combines furocoumarins, UV-A radiation, and a benzylidene-camphor derivative. The composition and treatment produces the desirable results of the furocoumarin/UV-A radiation treatment without the undesirable phototoxic side effects.
    Type: Grant
    Filed: April 30, 1990
    Date of Patent: February 19, 1991
    Assignee: L'Oreal
    Inventors: Gerard Lang, Andre Deflandre, Irena Beck
  • Patent number: 4975466
    Abstract: Pharmaceutical preparations for topical, i.e. dermal, application that contain as active ingredient a compound of the formula I ##STR1## especially 2-hydroxy-5-[(RS)-1-hydroxy-2-[[(RS)-1-(p-methoxyphenyl)-prop-2-yl]-amino] -ethyl]-formanilide (formoterol), or one of its pharmaceutically acceptable salts, especially its semifumarate, are proposed for the treatment of inflammatory skin diseases.
    Type: Grant
    Filed: December 7, 1988
    Date of Patent: December 4, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Irmgard Bottcher, Werner Pignat
  • Patent number: 4975272
    Abstract: A method of and composition for the prevention of solar radiation absorption-induced formation of carcinogenic skin lipid degradation products, particularly malonaldehyde, consisting of the application, prior to exposure of the skin to natural or artificial sources of solar radiation, of a composition comprising an ultraviolet screen--effective amount of an ultraviolet absorbing compound selected from the group consisting of a salicylate, a para-aminobenzoate, an alkyl ester of para-dialkylaminobenzoic acid, a benzophenone, a cinnamate, a napthoate, an acid-esterified gallate and mixtures thereof; at least one non-hindered, non-acid esterified, oil soluble, phenolic substituent-bearing latent oxidation inhibitor compound, such as the tocopherols, alcoholic esters of gallic acid, nordihydroguaiaretic acid, and mixtures thereof, the total concentration of said inhibitor present constituting a pro-oxidant-effective amount sufficient to demonstrate pro-oxidant properties, said inhibitor concentration further bein
    Type: Grant
    Filed: March 18, 1987
    Date of Patent: December 4, 1990
    Inventor: Walter F. Voyt
  • Patent number: 4963591
    Abstract: Skin care cosmetic formulations which include a cellulosic polymer/solvent system capable of dispersing thin, substantive films on the skin are disclosed.
    Type: Grant
    Filed: December 16, 1985
    Date of Patent: October 16, 1990
    Assignee: Carter-Wallace Inc.
    Inventors: Robert G. Fourman, Richard P. Dixon, Hans Breuer
  • Patent number: 4961927
    Abstract: An aqueous solution comprises lysozyme hydrochloride, dipotassium glycyrrhizinate, at least one selected from the group consisting of sodium chloride, potassium chloride, calcium chloride, magnesium chloride, sodium phosphate, potassium phosphate, sodium citrate, potassium citrate, sodium carbonate and potassium carbonate and water, has a pH of 5 to 9 and is useful for eye drops.
    Type: Grant
    Filed: November 25, 1987
    Date of Patent: October 9, 1990
    Assignee: Eisai Co., Ltd.
    Inventor: Yoshio Kogure
  • Patent number: 4960592
    Abstract: A composition for the treatment of dry skin comprises a mixture of lanolin and lanolin oil. Preferably, the composition contains about 75% by weight of lanolin and about 25% by weight of lanolin oil.
    Type: Grant
    Filed: April 17, 1989
    Date of Patent: October 2, 1990
    Assignee: Lanocare Laboratories
    Inventors: Resheda Hagen, Gabriel Barnett
  • Patent number: 4959205
    Abstract: Mild dermal inflammation, such as mild eczema and seborrhea, is treated by daily application of a composition comprising 0.25%-0.5% hydrocortisone, a protective amount of a sunscreen agent, and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 23, 1989
    Date of Patent: September 25, 1990
    Assignee: Collagen Corporation
    Inventors: Maureen Brunner, Howard Palefsky