Topical Treatment Patents (Class 514/887)
-
Patent number: 5166139Abstract: Complexes of saponins from Centella asiatica, terminalia sp. and Terminalia sericea and relevant aglycons with phospholipids are described. The saponins may be asiaticoside, madecassicoside and sericoside. The molar ratio of phospholipids to saponins is from 0.5 to 2. The phospholipids are selected from the group consisting of soy lecithins, phospholipids from bovine or swine brain or cutis, phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine in which the acyl groups can be the same or different and are mostly derived from palmitic, stearic, oleic, linoleic, linolenic acids. Pharmaceutical compositions and the method of treatment are also described.Type: GrantFiled: January 18, 1991Date of Patent: November 24, 1992Assignee: Indena, S.p.A.Inventors: Ezio Bombardelli, Gianfranco Patri, Roberto Pozzi
-
Patent number: 5165932Abstract: The invention relates to therapeutical compositions on medical herb basis for the treatment of psoriasis and the preparation of the same. A further object of the invention in the use of medical herbs as listed below in the treatment of psoriasis, rheumatism and asthmatic dyspnoea. The medical herbs used in the invention are as follows:Allium sativum /garlic/,Urtica dioica /common nettle/,Chelidonium majus /milkweed/,Veronica officinalis /veronica/,Calendula officinalis /calendula or marigold/,Achillea herba /millefolium/ /yarrow/,Fumaria officinalis /fumitory, earth-gall/.Type: GrantFiled: September 15, 1989Date of Patent: November 24, 1992Assignee: Unipharma Co., Ltd.Inventor: Ferenc Horvath
-
Patent number: 5158977Abstract: A 5,6,7,8-tetrahydro-1-naphthalenol derivative of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent lower alkyl,R.sub.5 and R.sub.6 represent hydrogen or lower alkyl,R represents hydrogen, C.sub.1 -C.sub.18 alkyl, C.sub.2 -C.sub.18 alkyl substituted by one or more hydroxyl groups, C.sub.3 -C.sub.18 alkenyl, C.sub.2 -C.sub.18 acyl, benzyl, benzoyl, carboxyl and carboxylic salts of an alkali or alkaline earth metal or of an organic amine.The derivative is useful as an antioxidant in cosmetic compositions and in pharmaceutical compositions for the preventive treatment of cutaneous inflammations and allergies or certain forms of cancer.Type: GrantFiled: June 7, 1991Date of Patent: October 27, 1992Assignee: L'OrealInventors: Jean Maignan, Gerard Malle, Andre Deflandre, Gerard Lang
-
Patent number: 5151534Abstract: Compounds corresponding to the formula: ##STR1## wherein A represents --(CH.sub.2).sub.2 or --(C.tbd.C)--;n is equal to 0, 1 or 2;R represents hydroxyl, alkoxy having the formula --OR.sub.1, or amino having the formula ##STR2## R.sub.1 represents alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or aralkyl;R.sub.2 and R.sub.3 represent hydrogen, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or benzyl;R.sub.2 and R.sub.3 form, with the nitrogen atom, a heterocyclic ring.Application of these compounds in pharmacy and cosmetics.Type: GrantFiled: May 10, 1989Date of Patent: September 29, 1992Assignee: Centre International de Recherches Dermatologiques (CIRD)Inventors: Braham Shroot, Christopher Hensby, Jean Maignan, Gerard Lang, Michel Colin
-
Patent number: 5151425Abstract: According to the invention, it has been found that plant cytokinins are effective in treating inflammation in mammals, such as humans. The plant cytokinins are effective to treat the inflammation, to accelerate healing of lesions, and to provide substantially immediate relief of pain, itching, and other immunological responses resulting from inflammation. The plant cytokinin is administered to the mammal in a suitable pharmaceutical preparation.Particular plant cytokinins which have been tested include trans-zeatin (trans-6-(4-hydroxy-3-methyl(but-2-enyl)-aminopurine)), 6-benzyl-adenine (6-benzylaminopurine), and kinetin (6-furfurylaminopurine).A composition for topical use in accordance with the method comprises an effective amount of the plant cytokinin in a carrier suitable for topical application to the human skin, for example, hydrophilic ointment, isopropyl alcohol, or a powder formulation.Type: GrantFiled: June 20, 1991Date of Patent: September 29, 1992Inventor: LeaLand L. Clark
-
Patent number: 5145679Abstract: A topical emollient for the treatment of circulation induced lesions comprises a source of glucose and insulin. The topical emollient is utilized in a process wherein the emollient is applied to the affected surface for nourishment thereof and promotion of healing. The emollient also enhances the therapeutic benefits of other medicinal drugs which may be topically applied in conjunction with the insulin and glucose mixture.Type: GrantFiled: October 9, 1990Date of Patent: September 8, 1992Inventor: Joan B. Hinson
-
Patent number: 5141951Abstract: Compounds of formula I ##STR1## wherein R.sub.1 is alkyl, alkoxy, alkylthio, alkylamino, aryl, aryloxy, arylthio, arylamino, aralkyl, aralkoxy, aralkylthio or aralkylamino,R.sub.2 and R.sub.3 are each independently hydrogen, halogen, hydroxy, mercapto, nitro or amino or have the meanings given for R.sub.1, andX is --NH.sub.2, --NH--OH, --N(R.sub.4)OH, --NH--NH.sub.2 or --NH--N.dbd.C(R.sub.4)R.sub.5, whereinR.sub.4 and R.sub.5 are each alkyl,in free form or pharmaceutically acceptable salt form, have pharmaceutical utility, in particular in the treatment or prophylaxis of asthma, or in the treatment of inflammation or psoriasis.Type: GrantFiled: November 27, 1991Date of Patent: August 25, 1992Assignee: Sandoz Ltd.Inventor: Hans-Jurg Wuthrich
-
Patent number: 5137718Abstract: A composition for a topically applied therapeutic cream or ointment having effective activity against one or a combination of sources of viral, bacterial, yeast and fungus infections characterized by the ability to penetrate beneath the epidermal layer of the skin. The composition includes a water soluble active component which is formulated with a water soluble organic solid base and a water soluble surfactant to form an aqueous solution having a gel-like consistency. A preferred active ingredient is a povidone-iodine complex. A preferred carrier is hydroxyethylcellulose.Type: GrantFiled: May 15, 1990Date of Patent: August 11, 1992Assignee: G&S Medical LtdInventor: C. Edward Gillespie
-
Patent number: 5137923Abstract: Lipophilic quaternary ammonium salicylate, characterized in that it corresponds to the formula: ##STR1## in which: (i) R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, denote an alkyl or alkylcycloalkyl radical, optionally substituted or interrupted;(ii) R.sub.3 and/or R.sub.4 denote(s) a group:R.sub.8 --OC.sub.2 H.sub.3 R.sub.7 ].sub.n [OCH.sub.2 CHOH--CH.sub.2 ].sub.pin which: 0.ltoreq.n.ltoreq.4 and p denotes 0 or 1; R.sub.8 denotes H or an alkyl, alkenyl, alkylcycloalkyl or alkylaryl radical;(iii) R.sub.4 denotes an alkylphenyl radical;(iv), (v) R.sub.1 and R.sub.2 can form a saturated or unsaturated aromatic or non-aromatic heterocycle;(vi) R.sub.1, R.sub.2 and R.sub.3 form polycyclic derivatives with the nitrogen atoms; R.sub.5 denotes a group corresponding to the formula: ##STR2## in which n is an integer varying between 0 and 10.Type: GrantFiled: June 21, 1990Date of Patent: August 11, 1992Assignee: L'OrealInventors: Michel Philippe, Henri Sebag, Michel Hocquaux, Bernard Jacquet, Jean P. Laugier
-
Patent number: 5134161Abstract: Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 is lower alkoxy or optionally substituted phenoxy,R.sup.2 is the same as R.sup.1, or R.sup.2 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenylalkyl,R.sup.3 is hydrogen, lower alkyl, lower alkoxy, halo, optionally substituted phenyl, optionally substituted phenyl-lower-alkyl or optionally substituted phenyl-lower-alkoxy, and m is 1 or 2;both X groups are the same and X is either --C(O)OR.sup.4 or --C(O)NR.sup.5 R.sup.6, whereinR.sup.4 is alkyl, phenyl or benzyl optionally substituted with one or two lower alkyl groups, lower alkoxy groups or halo; andR.sup.5 and R.sup.6 are independently hydrogen, lower alkyl, cycloalkyl or phenyl optionally substituted with one or two lower alkyl groups, lower alkoxy groups or halo.Type: GrantFiled: April 15, 1988Date of Patent: July 28, 1992Assignee: Syntex (U.S.A.) Inc.Inventors: Michael C. Venuti, John M. Young
-
Patent number: 5126135Abstract: The present invention relates to a dermatological composition composed for cosmetics or medicines for external application to skin and to oral or nasal mucous-membrane. This composition can be applied in particular in the cosmetic or pharmaceutical field, especially in the dermatological cases to regenerate and to revitalize damaged cells by equilibrating electrochemical ion gradients across cell membrane and also by osmotic pressure on the inner face of the cell membrane. A composition based on a water phase in accordence with present invention comprises dextran, glucose, mutan lentinan, NaCl, KCl, and CaCl.sub.2, which are dissolved in the aqueous phase.Type: GrantFiled: June 18, 1991Date of Patent: June 30, 1992Assignee: Japan Fine Chemical Co., Ltd.Inventors: Hajime Yamada, Akira Yamada
-
Patent number: 5126331Abstract: Compositions for topical use containing as active ingredients depolymerized deoxyribonucleic acids can be used for the reduction of the unaesthetisms of the face skin, due to the couperose. Said compositions can be advantageously used also to locally reduce, in the lower limbs, the skin unaesthetisms (dilated capillaries, oedemas, tumefactions), resulting from a situation of an extended physical stress acting on the above-mentioned legs.Type: GrantFiled: August 16, 1990Date of Patent: June 30, 1992Assignee: Crinos Industria Farmacobiologica S.p.A.Inventor: Giovanni Gazzani
-
Patent number: 5126375Abstract: Phenethanolamine derivatives are disclosed of formula ##STR1## wherein m is 2 to 8; n is 1 to 7 provided that m+n is 4 to 12;Ar is phenyl or phenyl substituted by one or two halogen atoms, alkyl or alkoxy groups or by an alkylenedioxy group;R.sup.1 and R.sup.2 are hydrogen or alkyl provided that the sum total of carbon atoms in R.sup.1 and R.sup.2 is not more than 4; and the physiologically acceptable salts and solvates thereof.The compounds have a selective stimulant action at .beta..sub.2 -adrenoreceptors and may be used inter alia in the treatment of diseases associated with reversible airways obstructions such as asthma and chronic bronchitis. The compounds may be formulated in conventional manner as pharmaceutical compositions with physiologically acceptable carriers or excipients.The compounds may be prepared, for example by alkylation of an amine: ##STR2## where R.sup.3, R.sup.5 and R.sup.6 is hydrogen or a protecting group, followed by removal of any protecting group.Type: GrantFiled: November 29, 1990Date of Patent: June 30, 1992Assignee: Glaxo Group Ltd.Inventors: Ian F. Skidmore, Lawrence H. C. Lunts, Harry Finch, Alan Naylor
-
Patent number: 5124320Abstract: An external analgesic lotion containing active ingredients of camphor and menthol to relieve pain in muscles, joints, or viscera distal at the site of application by stimulating cutaneous sensory receptors and a method of making such lotion and being made from camphor and menthol crystals.Type: GrantFiled: February 13, 1991Date of Patent: June 23, 1992Inventors: Jeffery W. Ivy, Curtis E. Payne
-
Patent number: 5106879Abstract: A treatment for inflammatory disorders, such as herpes simplex, eczema, shingles, atopic dermatitis, psoriasis, etc. The treatment includes the topical application of an ointment base containing a small quantity ot triacontanol. The triacontanol-ointment preparation is applied directly to the infected skin area as often as is needed.Type: GrantFiled: April 8, 1991Date of Patent: April 21, 1992Inventor: Lealand L. Clark
-
Patent number: 5104657Abstract: The invention relates to combination preparations containing chloramphenicol, gentamicin, nystatin and optionally a cortisone as active ingredients for the topical treatment of inflammatory skin disorders. The preparations are present preferably in the form of an ointment and have proved to be surprisingly effective particularly in the case of the treatment of skin disorders which are difficult to heal such as chronic eczema, inflammations in the anal and genital region, and of ulcus cruris and similar disorders.Type: GrantFiled: December 3, 1990Date of Patent: April 14, 1992Inventor: Souhail Abdulla
-
Patent number: 5104656Abstract: To prepare an analgesic, anti-inflammatory cream, ibuprofen-S is dissolved in the PEG-7-glycerylcocoate and propylene glycol by slightly warming the solution to about 40 degrees Centigrade. Fractionated coconut oil, di-isopropyladipate, stearic acid, cetyl alcohol, polyoxyl-40-stearate, sorbitan-monostearate and propylparaben are mixed and heated to 70 degrees Centigrade. Methylparaben Sod. is dissolved in demineralized water and heated to 70 degrees Centigrade. The above oil and water phase components are mixed together, cooled to about 50 degrees Centigrade and the ibuprofen-S solution is added to the emulsion. The emulsion is homogenized and cooled to room temperature to form the cream.Type: GrantFiled: June 16, 1989Date of Patent: April 14, 1992Inventors: Pyare L. Seth, Lorne A. Campbell
-
Patent number: 5096697Abstract: Cell-stimulating composition having hair-growing effect and skin-vivifying effect. The composition comprising as an effective ingredient an aliphatic alcohol having odd number of carbon atoms or a derivative thereof in a cosmetically acceptable carrier.Type: GrantFiled: August 23, 1989Date of Patent: March 17, 1992Assignee: Lion CorporationInventors: Kuniaki Adachi, Hideo Tamai, Masanao Sadai
-
Patent number: 5091182Abstract: A dispensing unit for a ketorolac topical gel formulation is disclosed, wherein the dispensing unit comprises a ketorolac topical gel formulation and a gas-impermeable multi-layered container wherein the container is comprised of a polyolefin inner layer and a metal foil outer layer.Type: GrantFiled: July 23, 1990Date of Patent: February 25, 1992Assignee: Syntex (U.S.A.) Inc.Inventors: John T. H. Ong, Jean S. Fujiki, Wei-Cheng Liaw
-
Patent number: 5087499Abstract: The present invention relates to improvements in puncture-resistant and medicinal treatment garments. Garments made from fibers such as KEVLAR.RTM. and designed to deter penetration of objects are subjected to an additional brushing step to enhance the fibers' abilities to prevent penetration of sharp needle-like penetrating objects. The fibers may also be coated with an abrasive material to further engage and deflect penetrating objects. In another aspect of the invention, the fibers may be coated with a disinfectant or pharmaceutical agent. The coated fibers, having the improved fiber structure resulting from the brushing step, may be used in fabrics to treat skin conditions, disinfect penetrating objects in puncture-resistant materials, or as a disinfecting prevention fabric for use in textiles in high risk infection areas such as hospitals and public facilities.Type: GrantFiled: May 9, 1990Date of Patent: February 11, 1992Inventor: Thomas M. Sullivan
-
Patent number: 5086050Abstract: Salts of azelastine with acetic acid, gluconic acid, lactic acid or malic acid.Type: GrantFiled: February 8, 1991Date of Patent: February 4, 1992Assignee: Asta Pharma AGInventors: Helmut Hettche, Reinhard Muckenschnabel, Gerhard Scheffler, Ilona Fleischhauer, Wolfgang Morick
-
Patent number: 5077036Abstract: Biocompatible fluorcarbon emulsions having fluorocarbon in concentrations of from 75% weight per volume to 125% weight per volume have small, biocompatible particle size stability through heat sterilization with one emulsifying agent, including phospholipids, in concentrations of from 3% to 7% weight per volume. The single emulsifying agent can be hydrogenated lecithins and synthesized lecithins. Fluorocarbon emulsions having fluorocarbon in concentrations of from 40% weight per volume to 125% weight per volume have stability of partial pressure of oxygen and of partial pressure of carbon dioxide through heat sterilization and storage for extended periods of time after having been oxygenated with dissolved oxygen.Type: GrantFiled: March 30, 1990Date of Patent: December 31, 1991Assignee: Alliance Pharmaceutical Corp.Inventor: David M. Long, Jr.
-
Patent number: 5071877Abstract: A cream or lotion consisting essentially of at least one active ingredient chosen from the alkali metal salts of certain oximes, phenols or polyethylene glycol monoethers, dispersed in a substantially anhydrous state in a base medium comprising of polyethylene glycol(s) which has (have) optionally been at least partially etherified to reduce the free hydroxyl group content thereof. These creams or lotions are effective against chemical warfare agents of both the V and G types, and against mustard gas (H or HD), and are simpler to make than known potassium salt-containing creams, for example those containing a macrocyclic ether and/or inert thickener and potassium phenate. These creams or lotions may be used both for protection and decontamination, and some may be used as personal barrier creams.Type: GrantFiled: April 11, 1989Date of Patent: December 10, 1991Inventors: Robert A. B. Bannard, Alfred A. Casselman, J. Garfield Purdon, Celso E. Mendoza
-
Patent number: 5071876Abstract: The compounds of this invention are anilides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided that n+m+p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is hydrogen or lower alkyl; and R.sub.4 is phenyl or substituted phenyl. The compounds of the present invention are useful in the treatment of inflammation, allergy and hypersensitivity reactions and other disorders of the immune system.Type: GrantFiled: July 27, 1990Date of Patent: December 10, 1991Assignee: G. D. Searle & Co.Inventors: Richard A. Mueller, Richard A. Partis, James R. Deason
-
Patent number: 5063060Abstract: The invention relates to a method of treating painful, inflammatory or allergic disorders comprising treatment with an effective amount of a composition comprising cis-8-methyl-N-vanillyl-6-nonenamide. The invention also relates to compositions for use in the inventive method.Type: GrantFiled: December 19, 1989Date of Patent: November 5, 1991Assignee: Cisco Limited PartnershipInventor: Joel E. Bernstein
-
Patent number: 5061491Abstract: A medicinal agent for treatment of mastitis in animals and humans which includes a mixture of a decoction of a mixture of the following medicinal herbs in equal parts by weight and an ammonia solution infusion which is a mixture of the same medicinal herbs in equal parts by weight, wherein the medicinal herbs include Matricaria chamomilla L., flores Calendulae officinalis L., Urtica dioica L., Erythreae centaurium Raf. L., gemmae Betula pendula Roth, Plantago major L., gammae Pinus sylvestris L., Origanum vulgare L., Salvia officinalis Hoffm., Archangelica officinalis Hoffm., Taraxacum officinale Web., folium Tussilaginis farfarae L., Sanguisorba officinalis L., Valeriana officinalis L., Menthae piperitae L., Thymus vulgaris L., and Bidens tripartita L. The decoction and infusion are mixed in a ratio to adjust the Ph of the mixture to not below 7.4. Also disclosed is a method of treating mastitis using the medicinal agent described above.Type: GrantFiled: July 21, 1989Date of Patent: October 29, 1991Inventor: Alexandr M. Deryabin
-
Patent number: 5061720Abstract: Disclosed are novel substituted 4-thiazolidinone derivatives having cyclooxygenase and 5-lipoxygenase inhibiting properties and which are topical antiinflammatory agents for inflammed conditions of the skin having the formula: ##STR1## wherein R is hydrogen or loweralkyl; R.sup.1 is loweralkyl or aryl; X is --(CH.sub.2)-aryl, --O--(CH.sub.2).sub.0-3 -aryl, --C(O)(CH.sub.2).sub.0-3 -aryl, --CH(OH)--(CH.sub.2).sub.0-3 -aryl or 3,4 ##STR2## (to form naphthyl ring); aryl is phenyl, substituted phenyl, or 2,3 or 4 pyridyl; W is oxygen; Q is -(alk.sup.1).sub.0-1 --(O).sub.0-1 --(B).sub.0-1 --(alk.sup.2).sub.0-1 --[C(O)Z].sub.0-1 ; B is ##STR3## Z is OR.sup.3 or NR.sup.4 R.sup.5 where R.sup.3 is hydrogen, loweralkyl, or a pharmaceutically acceptable metal cation, R.sup.4 and R.sup.5 are hydrogen or loweralkyl; alk.sup.1 and alk.sup.Type: GrantFiled: September 13, 1989Date of Patent: October 29, 1991Assignee: A. H. Robins Company, Inc.Inventors: David A. Walsh, Ibrahim M. Uwaydah
-
Patent number: 5061724Abstract: A method of treating inflammations of body joints in humans by topical application of anti-inflammatory agents may be used to treat joints afflicted by arthritic conditions such as gouty arthritis. The steps of the method include dissolving a predetermined quantity of a known anti-inflammatory drug, applying the medium with dissolved anti-inflammatory drug directly onto the skin covering a body joint known to be inflamed and allowing the medium with dissolved anti-inflammatory drug to be absorbed into the skin. Possible non-steroidal, anti-inflammatory drugs which may be used with the method include indomethacin, phenylbutazone and colchicine. Steroidal non-inflammatory drugs may also be used.Type: GrantFiled: July 18, 1989Date of Patent: October 29, 1991Inventor: Sheldon Gertner
-
Patent number: 5051438Abstract: This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl and m is 1 or 2;R.sup.1 is alkyl of 1 to 4 carbon atoms;R.sup.2 is hydrogen or alkyl of 1 to 5 carbon atoms;R.sup.4 is alkyl of 1 to 6 carbon atoms;n is an integer from 1 to 5; andY is NH or oxygen.The compounds of Formula I are leukotriene B.sub.4 antagonists and are useful as anti-inflammatory agents and in the treatment of LTB.sub.4 mediated diseases.Type: GrantFiled: May 16, 1990Date of Patent: September 24, 1991Assignee: G. D. Searle & Co.Inventors: Stevan W. Djuric, Thomas D. Penning
-
Patent number: 5047249Abstract: This invention relates to activated protein-containing compositions comprising reducing agents, oxidizing agents and/or anti-oxidants and methods of use. The therapeutic compositions and methods of the present invention are particularly effective in promoting wound healing, and in inhibiting certain skin disorders, including eczema and seborrhea, sclerodema and acne. The therapeutic compositions and methods of the present invention have also shown enhanced effect as veterinary tools in reducing the debilitation associated with certain skin conditions in mammals including eczematoid dermatitis, chronic dermatitis, equine exuberant granuloma ("proud flesh"), decubitis ulcers, and canine cutaneous granulomas ("lick" granuloma).Type: GrantFiled: March 3, 1989Date of Patent: September 10, 1991Assignee: John Morris Co., Inc.Inventors: John Rothman, Philip A. Band
-
Patent number: 5043162Abstract: Compositions containing mixtures of lower alkyl nicotinate and histamine hydrochloride, particularly useful in promoting hair growth and revitalizing the hair and scalp by topical application.Type: GrantFiled: September 5, 1990Date of Patent: August 27, 1991Inventor: Seymour F. Trager
-
Patent number: 5028428Abstract: Compositions and methods for reducing the adverse reaction of skin to chemicals and compositions that contact the skin, e.g., topical cosmetic and pharmaceutical preparations, and to contact physical irritants. The active ingredient of the composition of the invention comprises a hydro-alcoholic extract of Cola nitida.Type: GrantFiled: August 9, 1988Date of Patent: July 2, 1991Assignee: Estee Lauder Inc.Inventors: Walter P. Smith, Nicholas J. Pelliccione, Kenneth D. Marenus, Daniel H. Maes
-
Patent number: 5021452Abstract: There is disclosed a process for improving wound healing, comprising administering ascorbate or derivatives thereof to a wound site at a concentration of at least 20 .mu.mol/L and irradiating the wound site with a low-power laser at a wave length of about 600 nm to about 1100 nm. The process for improving wound healing can be used for the healing of deep, interior wounds with longer wave length radiation and higher energy output radiation. The process can further be used for improving the healing of superficial skin wounds with shorter wave lengths and lower energy output of the low-power laser.Type: GrantFiled: March 28, 1990Date of Patent: June 4, 1991Assignee: The Board of Regents of the University of WashingtonInventors: Robert F. Labbe, Rebecca L. Rettmer
-
Patent number: 5013726Abstract: An external analgesic lotion containing active ingredients of methyl salicylate and camphor and menthol to relieve pain in muscles, joints, or viscera distal at the site of application by stimulating cutaneous sensory receptors and a method of making such lotion and being made from camphor and menthol crystals.Type: GrantFiled: September 12, 1989Date of Patent: May 7, 1991Inventors: Jeffery W. Ivy, Curtis E. Payne
-
Patent number: 5013545Abstract: Aqueous gel compositions incorporate topically active pharmaceutical agents in a non-irritating gel comprising from about 60 to about 90% ethyl alcohol and from about 0.5 to about 30% water together with at least one gelling agent. Optional additives include gel enhancers, gel neutralizers, ultraviolet absorbers, gel clarifying agents, anti-irritants and moisturizers. The gel compositions exhibit good bactericidal and bacteriostatic activity in addition to the pharmaceutical activity of the active topical ingredient. Methods of treating skin areas in mammals requiring topical medication comprise the application of the gel, with or without the incorporation of a topically active ingredient, to the affected skin areas 1 to 5 times daily.Type: GrantFiled: December 9, 1987Date of Patent: May 7, 1991Assignee: Thames Pharmacal Co., Inc.Inventors: Steven Blackman, Irene Ralske
-
Patent number: 5008240Abstract: Inflammation, acute and/or chronic, is treated with a CIF (TGF-.beta.). The CIF may be administered locally or systemically, depending upon the indication, and does not require coadministration or activator or cofactor for efficacy.Type: GrantFiled: August 9, 1988Date of Patent: April 16, 1991Assignee: Collagen CorporationInventors: Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
-
Patent number: 5006337Abstract: Medicinal and cosmetic compositions for the treatment of skin disorders and for care of dry and/or irritated skin and of dry scalp with dandruff are prepared using brewers' grains extract(s)--especially a brewers' grains extract obtained using liquid or above-critical CO.sub.2 or N.sub.2 O.Type: GrantFiled: April 14, 1988Date of Patent: April 9, 1991Assignee: Marbert GmbHInventors: Lothar Motitschke, Hagen Tronnier
-
Patent number: 5002767Abstract: The invention relates to a therapeutic composition containing, as the active principle, .alpha.-linolenic acid and an alcohol of vegetable origin, such as a tocopherol or sitosterol. Preferably, the composition contains other fatty acids and is an organic extract of plants, especially of the Resedaceae family.The invention also relates to the plant extracts as novel products.The therapeutic composition is especially useful as an antiinflammatory.Type: GrantFiled: August 24, 1988Date of Patent: March 26, 1991Assignee: Laboratories Natura MedicaInventor: Jean-Pierre Masse
-
Patent number: 5001156Abstract: Lipophilic quaternary ammonium salicylate, characterized in that it corresponds to the formula: ##STR1## in which: (i) R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, denote an alkyl or alkylcycloalkyl radical, optionally substituted or interrupted;(ii) R.sub.3 and/or R.sub.4 denote(s) a group:R.sub.8 [OC.sub.2 H.sub.3 R.sub.7 ].sub.n [OCH.sub.2 CHOH--CH.sub.2 ].sub.pin which 0.ltoreq.n.ltoreq.4 and p denotes 0 or 1; R.sub.8 denotes H or an alkyl, alkenyl, alkylcycloalkyl or alkylaryl radical;(iii) R.sub.4 denotes an alkylphenyl radical;(iv), (v) R.sub.1 and R.sub.2 can form a saturated or unsaturated aromatic or non-aromatic heterocycle;(vi) R.sub.1, R.sub.2 and R.sub.3 form polycyclic derivatives with the nitrogen atoms; R.sub.5 denotes a group corresponding to the formula: ##STR2## in which n is an integer varying between 0 and 10.Type: GrantFiled: December 1, 1987Date of Patent: March 19, 1991Assignee: L'OrealInventors: Michel Philippe, Henri Sebag, Michel Hocquaux, Bernard Jacquet, Jean P. Laugier
-
Patent number: 5001119Abstract: Compounds of the formula: ##STR1## are useful as anti-cancer, anti-obesity, anti-diabetic, anti-coronary agents, anti-aging agents, anti-hypolipidemic agents and anti-autoimmune agents.Type: GrantFiled: November 25, 1987Date of Patent: March 19, 1991Inventors: Arthur G. Schwartz, Marvin L. Lewbart
-
Patent number: 4999195Abstract: Personal care products comprising bioemulsifiers, for example, those produced by Acinetobacter calcoaceticus, are provided. Use of such personal care products result in beneficial effects to skin and hair.Type: GrantFiled: July 5, 1989Date of Patent: March 12, 1991Assignee: Emulsan Biotechnologies Inc.Inventor: Michael E. Hayes
-
Patent number: 4996193Abstract: The present invention provides formulations for the topical application of cyclosporin to skin tissue for treatment of autoimmune, T-cell mediated immune disease, and inflammatory conditions, and for producing prolonged skin allograft survival and wound healing. In addition, methods for the use of said formulations--in tandem with systemic applications of cyclosporin or without same--are suggested. The present invention also suggests alternative formulations and delivery systems for the efficacious treatment of the aforementioned conditions, and further suggests a model with which formulations may be tested.Type: GrantFiled: March 3, 1989Date of Patent: February 26, 1991Assignee: The Regents of the University of CaliforniaInventors: Charles W. Hewitt, Kirby S. Black
-
Patent number: 4994497Abstract: A method is provided of avoiding or minimizing inflammation at a painful freshly burned epidermal skin site, which comprises applying on the skin site promptly before the appearance of overt inflammation, an anti-inflammatory composition in homogeneous non-alcoholic aqueous solution form consisting essentially of distilled hamamelis water, magnesium sulfate, and copper sulfate to allow for transdermal absorption of the composition at the skin site for a period sufficient to achieve local relief of inflammatory symptoms.Type: GrantFiled: October 11, 1989Date of Patent: February 19, 1991Inventor: Orlyn G. Pepper
-
Patent number: 4994263Abstract: A composition for treatment and treatment of certain skin diseases is disclosed. The treatment combines furocoumarins, UV-A radiation, and a benzylidene-camphor derivative. The composition and treatment produces the desirable results of the furocoumarin/UV-A radiation treatment without the undesirable phototoxic side effects.Type: GrantFiled: April 30, 1990Date of Patent: February 19, 1991Assignee: L'OrealInventors: Gerard Lang, Andre Deflandre, Irena Beck
-
Patent number: 4975466Abstract: Pharmaceutical preparations for topical, i.e. dermal, application that contain as active ingredient a compound of the formula I ##STR1## especially 2-hydroxy-5-[(RS)-1-hydroxy-2-[[(RS)-1-(p-methoxyphenyl)-prop-2-yl]-amino] -ethyl]-formanilide (formoterol), or one of its pharmaceutically acceptable salts, especially its semifumarate, are proposed for the treatment of inflammatory skin diseases.Type: GrantFiled: December 7, 1988Date of Patent: December 4, 1990Assignee: Ciba-Geigy CorporationInventors: Irmgard Bottcher, Werner Pignat
-
Patent number: 4975272Abstract: A method of and composition for the prevention of solar radiation absorption-induced formation of carcinogenic skin lipid degradation products, particularly malonaldehyde, consisting of the application, prior to exposure of the skin to natural or artificial sources of solar radiation, of a composition comprising an ultraviolet screen--effective amount of an ultraviolet absorbing compound selected from the group consisting of a salicylate, a para-aminobenzoate, an alkyl ester of para-dialkylaminobenzoic acid, a benzophenone, a cinnamate, a napthoate, an acid-esterified gallate and mixtures thereof; at least one non-hindered, non-acid esterified, oil soluble, phenolic substituent-bearing latent oxidation inhibitor compound, such as the tocopherols, alcoholic esters of gallic acid, nordihydroguaiaretic acid, and mixtures thereof, the total concentration of said inhibitor present constituting a pro-oxidant-effective amount sufficient to demonstrate pro-oxidant properties, said inhibitor concentration further beinType: GrantFiled: March 18, 1987Date of Patent: December 4, 1990Inventor: Walter F. Voyt
-
Patent number: 4963591Abstract: Skin care cosmetic formulations which include a cellulosic polymer/solvent system capable of dispersing thin, substantive films on the skin are disclosed.Type: GrantFiled: December 16, 1985Date of Patent: October 16, 1990Assignee: Carter-Wallace Inc.Inventors: Robert G. Fourman, Richard P. Dixon, Hans Breuer
-
Patent number: 4961927Abstract: An aqueous solution comprises lysozyme hydrochloride, dipotassium glycyrrhizinate, at least one selected from the group consisting of sodium chloride, potassium chloride, calcium chloride, magnesium chloride, sodium phosphate, potassium phosphate, sodium citrate, potassium citrate, sodium carbonate and potassium carbonate and water, has a pH of 5 to 9 and is useful for eye drops.Type: GrantFiled: November 25, 1987Date of Patent: October 9, 1990Assignee: Eisai Co., Ltd.Inventor: Yoshio Kogure
-
Patent number: 4960592Abstract: A composition for the treatment of dry skin comprises a mixture of lanolin and lanolin oil. Preferably, the composition contains about 75% by weight of lanolin and about 25% by weight of lanolin oil.Type: GrantFiled: April 17, 1989Date of Patent: October 2, 1990Assignee: Lanocare LaboratoriesInventors: Resheda Hagen, Gabriel Barnett
-
Patent number: 4959205Abstract: Mild dermal inflammation, such as mild eczema and seborrhea, is treated by daily application of a composition comprising 0.25%-0.5% hydrocortisone, a protective amount of a sunscreen agent, and a pharmaceutically acceptable carrier.Type: GrantFiled: March 23, 1989Date of Patent: September 25, 1990Assignee: Collagen CorporationInventors: Maureen Brunner, Howard Palefsky