Topical Treatment Patents (Class 514/887)
  • Topical drug preparations
    Patent number: 5897880
    Abstract: Topical gelled compositions comprising an optional drug dispersed within a polymer matrix, methods of producing the same and treatments with the complex.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: April 27, 1999
    Assignee: Lam Pharmaceuticals, LLC.
    Inventors: Alan Drizen, Peter Rothbart, Gary M. Nath
  • Method for treating neurogenic red skin blotches with compositions containing TNF-alpha antagonists
    Patent number: 5895649
    Abstract: Topically applicable pharmaceutical/dermatological/cosmetic compositions, well suited for the therapeutic treatment of neurogenic red skin blotches and rosacea afflicting the skin, scalp and/or mucosae of a human subject, comprise a therapeutically/cosmetically effective amount of at least one TNF-alpha antagonist.
    Type: Grant
    Filed: November 20, 1996
    Date of Patent: April 20, 1999
    Assignee: Societe L'Oreal S.A.
    Inventors: Olivier De Lacharriere, Lionel Breton
  • Topically applied pharmaceutical composition, method of preparing it and its use
    Patent number: 5894019
    Abstract: A topically applicable pharmaceutical composition comprises at least one liquid lipid, at least one pharmaceutical active ingredient which is soluble in at least one of the liquid lipids and is re-absorbed by the skin, and a hydrous gel which is the main component of the composition, whereby at least one lipid and at least one active ingredient are worked into the gel and the composition is essentially free of emulsifying agents and solid constituents, with the exception of the necessary gelatinizing agent required to form the hydrous gel. All of the active ingredients are present in dissolved form, whereby at least one active ingredient is dissolved in the liquid lipid, and this lipid containing the dissolved active ingredient is itself the internal phase and is worked into the hydrous gel as the external phase. The composition is also essentially free of surface-active substances.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: April 13, 1999
    Assignee: GEBRO Broschek Gesellschaft m.b.H.
    Inventors: Ernst Hesse, Gerhard Hantich, Volker Eisenreich, Torsten Moller
  • Tissue protective and regenerative compositions
    Patent number: 5888522
    Abstract: Methods are provided for preparing compositions suitable for protecting irritated or damaged skin from further oxidative and biochemical damage and thus permitting natural healing processes to progress, for accelerating the rate of healing of burns and surgical wounds, for stimulating melanogenesis, and for increasing the size of hair follicles and the rate of hair growth. The compositions generally comprise complexation of peptone digests of various proteins with copper(II) salts, indium (III) salts, tin(II) salts and tin(IV) salts.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: March 30, 1999
    Assignee: Skin Biology, Inc.
    Inventor: Loren R. Pickart
  • Cosmetic composition with a retinol fatty acid ester
    Patent number: 5885595
    Abstract: A method and composition is provided for enhancing skin radiance and treating chronoaging conditions including wrinkles and dermatological disorders including acne, follicular and lesional papules, actinic keratoses, oily skin and rosacea comprising: (i) a safe and effective amount of an unsaturated C.sub.18 -C.sub.30 fatty acid ester of retinol; and (ii) a safe and effective amount of a cosmetically acceptable carrier, the composition being stable for at least four weeks at 43.degree. C. An unsaturated C.sub.18 -C.sub.30 fatty acid ester of retinol is the active component which is applied to the skin in a cosmetically acceptable carrier. The most preferred unsaturated retinol fatty acid ester is retinyl linoleate. The composition is stable and remains active for at least four weeks at 43.degree. C.
    Type: Grant
    Filed: April 7, 1997
    Date of Patent: March 23, 1999
    Assignee: Elizabeth Arden Co., Division of Conopco, Inc.
    Inventors: Joseph Corey, Peter Ladislav Dorogi, Alan Joel Meyers, Anthony Vargas
  • Topical composition for the relief of pain
    Patent number: 5885597
    Abstract: Disclosed is a topical composition for relieving pain in a person in need of such relief, consisting essentially of an effective amount of a combination of at least one corticoid analgesic, at least one arylpropionic acid type analgesic, and at least one p-aminobenzoic acid ester type local anesthetic; an amount effective in enhancing the effectiveness in relieving pain of the combination of capsaicin, and an amount effective to increase the transmission thereof of through the skin of at least one phospholipid and at least one polyoxyethylenepolyoxypropylene copolymer.
    Type: Grant
    Filed: October 1, 1997
    Date of Patent: March 23, 1999
    Assignee: Medical Research Industries,Inc.
    Inventors: Jonah Botknecht, Robert Fishman
  • Use of carotenoids for producing drugs for the treatment of dermatoses
    Patent number: 5886053
    Abstract: The use of carotenoids for producing drugs for the treatment of inflammatory disorders not caused by the action of light or an infection with microorganisms.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: March 23, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfgang Schmutzler, Karl Kolter
  • Compositions for regulating skin wrinkles and/or skin atrophy
    Patent number: 5883085
    Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
    Type: Grant
    Filed: April 20, 1998
    Date of Patent: March 16, 1999
    Assignee: The Procter & Gamble Company
    Inventors: Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
  • Method and composition for tropical treatment of damaged tissue using histamine phosphate as active ingredient
    Patent number: 5882639
    Abstract: A method for treating photodermatitis, thermal burn, decubitus ulcer, or herpes zoster by topically applying a composition comprising a water soluble vinyl polymer gel or lotion comprising 1H-imidazole-4-ethanamine, phosphate uniformly mixed therewith to the affected areas.
    Type: Grant
    Filed: February 9, 1998
    Date of Patent: March 16, 1999
    Assignee: Professional Pharmaceutical, Inc.
    Inventors: Bruce A. Jack, B. Thomas White
  • Topical pain-relieving preparation containing C.sub.12 To C.sub.18 isoparaffins
    Patent number: 5882663
    Abstract: A method for providing pain relief includes topically applying to skin tissue an effective amount of higher homologs of isoparaffins, ranging from about C.sub.12 to C.sub.18. Compositions of the present invention include, with the isoparaffins in a mixture, at least one from the group consisting of salicylate, capsaicin, camphor, and menthol. Other constituents may be added for form creams or lotions.
    Type: Grant
    Filed: June 2, 1997
    Date of Patent: March 16, 1999
    Inventors: Erich A. Koeniger, Drahoslay Lim
  • Skin care compounds and preparation thereof
    Patent number: 5882666
    Abstract: It has long been the practice to treat the skin of individuals to clean and soften the skin with soaps and detergents. A compound containing glycerin, alcohol, jojoba oil, aloe vera, silk extracts, glyceryl monostearate, decyl oleate, propylene glycol, isopropyl palmitate, dimethicone, magnesium ascorbyl phosphate, sodium dodecyl sulfate, methyl paraben, xanthan gum, propyl paraben, and deionized water are formed into a silk cream composition in order to clean and soften skin. A lotion form of the compound that adds natural fragrances and mineral oil is also disclosed. A method of using the skin cream and or the lotion is also disclosed.
    Type: Grant
    Filed: November 20, 1997
    Date of Patent: March 16, 1999
    Inventors: Robert G. Averill, Miriam Averill
  • Phytosphingosine salicylates in cosmetic compositions
    Patent number: 5882665
    Abstract: A novel series of phytosphingosines are disclosed which are phytosphingosine salicylates having use in cosmetic compositions. They have potential as anti-acne, anti-blemish, anti-bacterial and anti-wrinkle agents, as well as being active in skin lightening.
    Type: Grant
    Filed: November 18, 1997
    Date of Patent: March 16, 1999
    Assignee: Elizabeth Arden Co., Division of Conopco, Inc.
    Inventors: Alan Joel Meyers, Joseph Michael Corey, Anthony Vargas
  • Tocopheryl ascorbyl phosphate-cyclodextrin clathrate and a topical dermal composition containing said clathrate
    Patent number: 5879692
    Abstract: The invention provides a clathrate comprising a cyclodextrin or hydroxyalkylated cyclodextrin and, as included therein, dl-.alpha.-tocopheryl L-ascorbyl phosphate. In another aspect, the invention provides a dermal composition for external use, particularly a cosmetic composition. The composition is characterized by reduced foam production in aqueous solution and good stability against light.
    Type: Grant
    Filed: August 25, 1997
    Date of Patent: March 9, 1999
    Assignee: Senju Pharmaceutical Co., Ltd.
    Inventors: Yohei Hamano, Hajime Matsuda, Hideyuki Sumiyoshi
  • Hydroxy-acid cosmetics
    Patent number: 5879688
    Abstract: A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: March 9, 1999
    Assignee: Focal, Inc.
    Inventors: Arthur J. Coury, Luis Z. Avila, Chandrashekhar P. Pathak, Shikha P. Barman
  • Cosmetic composition containing molecular oxygen
    Patent number: 5874093
    Abstract: A composition containing a dermatologically acceptable carrier in admixture with molecular oxygen promotes and improves respiratory function of skin cells. The composition may be used in cosmetic compositions.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: February 23, 1999
    Inventors: Isaac Eliaz, Shmuel Gonen
  • Topical application for relief of adverse skin condition for animals
    Patent number: 5874474
    Abstract: This invention is a composition and a method for treating animal skin ailments by a topical application of the composition to the animal in which the composition is a liquid or gel having potassium formate, sodium formate, or cesium formate in water in an effective concentration. Typically, the skin ailments treated are those caused by pyotraumatic dermatitis, chronic itching, scratching and chewing, and flea and insect bites in dogs, cats, horses and other animals.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: February 23, 1999
    Inventors: Thomas E. Peterson, Byron A. Church
  • Use of salicylic acid for regulating skin wrinkles and/or skin atrophy
    Patent number: 5872112
    Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
    Type: Grant
    Filed: October 21, 1997
    Date of Patent: February 16, 1999
    Assignee: Richardson-Vicks Inc.
    Inventor: Roy Lonnie Blank
  • Compositions for regulating skin wrinkles and/or skin atrophy
    Patent number: 5869470
    Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: February 9, 1999
    Assignee: The Procter & Gamble Company
    Inventors: Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
  • Body polisher
    Patent number: 5866145
    Abstract: A body polisher and method of using the body polisher as a skin treatment, includes a two phase composition containing Dead Sea salt and emollient. The emollient is advantageously silicone oil and is present in about 32.67% by weight. About 66.66% by weight Sea salt is provided, the remainder being fragrance.
    Type: Grant
    Filed: January 28, 1997
    Date of Patent: February 2, 1999
    Assignee: Bath & Body Works, Inc.
    Inventors: Vera Stavroff, Neil Goeren
  • Starch-metal complexes for skin and hair
    Patent number: 5858993
    Abstract: Methods are provided for preparing compositions suitable for protecting irritated or damaged skin from further oxidative and biochemical damage and thus permitting natural healing processes to progress, for accelerating the rate of healing of burns and surgical wounds, and for increasing the size of hair follicles and the rate of hair growth. The compositions generally comprise precipitates formed by the complexation of starch of various plants with ionic transition metals, such as copper(II) and tin(II) salts.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: January 12, 1999
    Assignee: Skin Biology, Inc.
    Inventor: Loren R. Pickart
  • Silicone phosphate esters as irritation mitigants
    Patent number: 5859161
    Abstract: The present invention relates to a series of novel silicone phosphate esters which mitigate eye and skin irritation when used in synergistic combinations with fatty alcohol sulfates and fatty alcohol ether sulfates. These materials form complexes which have surprisingly low irritation properties.
    Type: Grant
    Filed: December 6, 1993
    Date of Patent: January 12, 1999
    Assignees: Phoenix Chemical, Lambent Technologics Inc
    Inventors: John Imperante, Anthony J. O'Lenick, Jr.
  • Methods of using ajoene
    Patent number: 5856363
    Abstract: The progression of infection and other pathologies produced by a viral infection may be inhibited by administering an effective dosage of Ajoene. Additionally, Ajoene has anti-tumor, anti-shock, and anti-inflammation effects. In general, Ajoene may be used to treat any integrin-mediated disease or condition.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: January 5, 1999
    Assignee: John B. Davidson
    Inventors: Alexander V. Tatarintsev, Ali S. Turgiev, John B. Davidson
  • Pain reliever and method of use
    Patent number: 5856361
    Abstract: A composition containing capsaicin together with another ingredient to neutralize the discomfort resulting from the application of capsaicin to the skin can be used to treat many types of discomforts, including musculo-skeletal pain, neuralgia and neurpathies, without the discomfort normally associated with the topical application of capsaicin.
    Type: Grant
    Filed: June 6, 1997
    Date of Patent: January 5, 1999
    Assignee: Medical Merchandising, Inc.
    Inventors: Stephen D. Holt, Timothy R. Laughlin
  • Compositions comprising IL-11 and methods of making and using IL-11
    Patent number: 5854028
    Abstract: A novel mammalian cytokine, IL-11, and processes for producing it are disclosed. IL-11 may be used in pharmaceutical preparations for stimulating and/or enhancing cells involved in the immune response and cells involved in the proper functioning of the hematopoietic system.
    Type: Grant
    Filed: March 10, 1997
    Date of Patent: December 29, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Yu-Chung Yang, Frances K. Bennett, Stephan R. Paul
  • Anhydrous cosmetic compositions
    Patent number: 5849314
    Abstract: A skin treatment composition is provided which includes a crosslinked non-emulsifying siloxane elastomer, a skin conditioning agent, a volatile siloxane and no more than 5% water. Hydrocarbons such as petrolatum and polyols such as glycerin are the preferred skin conditioning agents. Inclusion of the elastomer provides a non-traditional smooth/silky feel to the skin upon application with a non-draggy rub in.
    Type: Grant
    Filed: March 20, 1997
    Date of Patent: December 15, 1998
    Assignee: Chesebrough-Pond's USA Co., Division of Conopco, Inc.
    Inventors: Brian John Dobkowski, Alexander Paul Znaiden, Michael Charles Cheney, Walter Rose
  • Pharmaceutical compositions containing alkylaryl polyether alcohol polymer
    Patent number: 5849263
    Abstract: There is provided novel pharmaceutical compositions containing tyloxapol as the active ingredient. These formulations comprise tyloxapol at concentrations above 0.125%, preferably from about 0.25% to about 5.0%. In addition, the invention encompasses pharmaceutical compositions having reduced hypertonicity which compositions comprise tyloxapol in pharmaceutically acceptable solutions without significant concentrations of hypertonic agents or other active ingredients NaHCO.sub.3, or active phospholipids, such as DPPC. The less hypertonic formulations allow one to derive all the benefits of the active ingredient tyloxapol, such as its reduced toxicity and enhanced half-life, while avoiding or reducing side effects, such as bronchospasms, associated with the various hypertonic agents or other active ingredient agents.
    Type: Grant
    Filed: April 25, 1996
    Date of Patent: December 15, 1998
    Assignee: Charlotte-Mecklenburg Hospital Authority
    Inventor: Thomas P. Kennedy
  • Medicaments based on metronidazole or on a synergic mixture of metronidazole and clindamycin
    Patent number: 5849776
    Abstract: The invention relates to the use of metronidazole, or preferably of a combination of metronidazole and clindamycin, as active principle for the manufacture of pharmaceutical compositions, more particularly dermatological compositions, intended for an anti-inflammatory treatment by the topical route.
    Type: Grant
    Filed: March 25, 1997
    Date of Patent: December 15, 1998
    Assignee: Centre International de Recherches Dermatologiques Galderma (C.I.R.D. Galderma)
    Inventors: Janusz Czernielewski, Josiane Allec, Martine Bouclier
  • Bovine mastitis treatment
    Patent number: 5846543
    Abstract: Chemical compositions for the treatment of bovine mastitis which compositions are combinations of four components i.e.; Echinechea Goldenseal Supreme; Wild Ginseng Supreme; gelsemium, pokeroot, and aconite; and aloe vera juice, which form a dose which is injected into the mastitis affected portion of a cow's udder for a minimum of two doses per day for at least three days, which results in a cure for the mastitis.
    Type: Grant
    Filed: October 24, 1995
    Date of Patent: December 8, 1998
    Inventors: Mark A. Hassler, Lisa M. Hassler
  • Topical ointment consisting of animal fat, plantain lancetowata, and calendula and methods of producing the same
    Patent number: 5843467
    Abstract: A composition for a topically healing ointment having all natural herbs and an animal fat base. The combination of which forms a salve that is active against one or a combination of sources of viral, bacterial and fungus infections that have the ability to penetrate beneath the epidermal layer of the skin.
    Type: Grant
    Filed: July 15, 1996
    Date of Patent: December 1, 1998
    Inventor: Wieslaw Ambroziewigz
  • 2-phenylazulene derivatives and a manufacturing method of these compounds
    Patent number: 5843999
    Abstract: A series of new azulene derivatives are disclosed, which are represented by the following formula; ##STR1## wherein: R.sub.1 is hydrogen atom, lower alkoxycarbonyl group, carboxy group, halogen atom, lower alkyl group, phenyl group or lower alkanoyl group; R.sub.2, R.sub.3 and R.sub.4 are hydrogen atom, lower alkyl group, lower alkoxy group or halogen atom; X is lower alkyl group or amino group.The compounds of the present invention are useful for treatment of inflammation.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: December 1, 1998
    Assignee: Kotobuki Seiyaku Co., Ltd.
    Inventors: Tsuyoshi Tomiyama, Akira Tomiyama, Masayuki Yokota, Satoko Uchibori
  • Use of salicyclic acid for regulating skin wrinkles and/or skin atrophy
    Patent number: 5843926
    Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: December 1, 1998
    Assignee: Richardson-Vicks Inc.
    Inventor: Roy Lonnie Blank
  • Immunotherapy composition and method
    Patent number: 5843452
    Abstract: A composition for use in immunosuppression therapy is disclosed. The composition includes an immunosuppressant drug, such as cyclosporin A, and an ethanol extract of the root xylem of Tripterygium wilfordii. The extract is effective alone, or in combination with such an immunosuppressant, in the treatment of transplantation rejection. Also disclosed is a method of immunosuppression that includes administering to a subject a pharmaceutically effective amount of an immunosuppressant drug and an extract of the type above, in an amount effective to potentiate the action of the drug.
    Type: Grant
    Filed: June 2, 1994
    Date of Patent: December 1, 1998
    Assignee: Pharmagenesis, Inc.
    Inventors: Tien-Wen Tao Wiedmann, Jian Wang, Nathan B. Pliam, Hank C. K. Wuh
  • Method of applying magnesium-rich calcium montmorillonite to skin for oil and organic compound sorption
    Patent number: 5840320
    Abstract: A method of increasing the bulk density and improving the water-dispersibility, oil sorption capacity, and body dirt and oil removability by compacting and/or shearing a magnesium rich calcium montmorillonite clay. In an optional embodiment of the present invention, silica gel, sodium silicate, acrylic polymers and copolymers, carboxy methyl cellulose, or other materials capable of providing lubricity to the surface of the clay crystals is added to the clay, prior to shearing, to enhance the compaction and/or shearing process and further increase the bulk density of the clay. The clay is sheared in an extruder, pug mill or California-type pellet mill when the clay includes about 20% to about 45%, preferably about 25% to about 40% by weight water, based on the dry weight of the clay.
    Type: Grant
    Filed: October 25, 1995
    Date of Patent: November 24, 1998
    Assignee: AMCOL International Corporation
    Inventor: Ira Edgar Odom
  • Use of salysylic acid for regulating skin wrinkles and/or skin atrophy
    Patent number: 5840717
    Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: November 24, 1998
    Assignee: Richardson-Vicks Inc.
    Inventor: Roy Lonnie Blank
  • Oxime derivatives of fenamates as inhibitors of prostaglandin biosynthesis
    Patent number: 5840758
    Abstract: Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein Y is selected from halogen, alkyl, and haloalkyl; n is 0, 1, 2, or 3; A is selected from (a) optionally substituted alkylene, (b) optionally substituted cycloalkylene, (c) optionally substituted cycloalkylene wherein one or two of the carbon atoms is replaced with one or two heteroatoms independently selected from O, S, and N, (d) optionally substituted alkenylene and (e) ##STR2## X is absent or is alkylene; Z is selected from (a) hydrogen, (b) COM wherein M is selected from --OR.sup.4, --NR.sup.6 R.sup.7, and a pharmaceutically acceptable metabolically cleavable group, (c) --OR.sup.2, (d) tetrazolyl, (e) --CH(OR.sup.2)--CH.sub.2 OR.sup.8, (f) --CH(OR.sup.2)--CH.sub.2 --CH.sub.2 OR.sup.8, (g) --CH(OR.sup.2)--CH(OR.sup.8)--CH.sub.2 OR.sup.9, and (h).dbd.N--OR.sup.2 ; and R.sup.
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: November 24, 1998
    Assignee: Abbott Laboratories
    Inventors: Clint D. W. Brooks, Teodozyj Kolasa, Wendy Lee, Andrew O. Stewart
  • Compositions for regulating skin wrinkles and/or skin atrophy
    Patent number: 5837697
    Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
    Type: Grant
    Filed: December 16, 1996
    Date of Patent: November 17, 1998
    Assignee: The Procter & Gamble Company
    Inventors: Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
  • Antiinflammatory agent for external use
    Patent number: 5837735
    Abstract: An antiinflammatory agent for external use, containing nimesulide as the active ingredient dispersed in the base component and being well absorbable, safe and discoloration-free.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: November 17, 1998
    Assignee: Helsinn Healthcare S.A.
    Inventors: Satoru Miyata, Yasuaki Taniguchi, Kenji Masuda, Yoichi Kawamura
  • Topical application of opioids for treatment of acne and sebaceous gland disorders
    Patent number: 5834480
    Abstract: Treatment of acne through topical administration is an aspect of the present invention. Specifically, opioids may be applied in any therapeutically acceptable carrier including gels, creams, lotions, and sprays. Therapeutic effects observed with the present invention include decrease in redness, swelling, and inflammation. Treatment of other inflammatory conditions is also disclosed. Treatment of suitable conditions in accordance with the present invention results in significant improvements in healing of those conditions.
    Type: Grant
    Filed: June 13, 1997
    Date of Patent: November 10, 1998
    Inventor: George F. Elkhoury
  • Compositions containing a form of hyaluronic acid and a medicinal agent for treating acne in mammals and methods for administration of such composition
    Patent number: 5830882
    Abstract: A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments and subunits of hyaluronic acid sufficient to facilitate the agent's penetration through the tissue (including scar tissue) at the site to be treated, through the cell membranes into the individual cells to be treated.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 3, 1998
    Assignee: Hyal Pharmaceutical Corporation
    Inventors: Rudolf Edgar Falk, Samuel S. Asculai
  • Phospholipid-and cholestrol-free aqueous composition for topical application to the skin
    Patent number: 5830499
    Abstract: Phospholipid- and cholesterol-free aqueous compositions for topical application to the skin contain a pharmaceutically active ingredient and a vector system of controlled and in-depth transport and release of the active ingredient through the skin. The vector system comprises at least one first non-ionic surfactant which forms vesicles upon dispersion in water and a lamellar phase upon concentrating the vesicles, and at least one second non-ionic hydrophilic surfactant. The ratios of the two non-ionic surfactants are such that the vector system comprises flexible vesicles.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: November 3, 1998
    Assignee: Rijksuniversiteit Leiden
    Inventor: Johanna Aaltje Bouwstra
  • Use of a hymenoptera venom for the manufacture of a medicament for treating DNA virus infections
    Patent number: 5827829
    Abstract: The present invention relates to the use of hymenoptera venom or proteinaceous or polypeptide components contained therein in the manufacture of a medicament for treating DNA virus infections, and to a method for the treatment of mammalian DNA virus infections which uses hymenoptera venom or proteinaceous or polypeptide components contained therein.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: October 27, 1998
    Inventors: Michael Hansen, Ole Gyring Nieben
  • Pharmaceutical base and the use of the same
    Patent number: 5817322
    Abstract: The invention relates to the preparation and struction of a kind of pharmaceutical base comprising 5% to 25% by weight of beeswax and 95% to 75% by weight of a hydrophobic solvent. The pharmaceutical base has a netted framework structure with beeswax being the frame and the hydrophobic solvent being included in the frame. Also, the present invention relates to pharmaceutical compositions, dressing and cosmetics prepared by using the base and the method for preparing the same.
    Type: Grant
    Filed: March 22, 1996
    Date of Patent: October 6, 1998
    Inventor: Rongxiang Xu
  • Compositions for regulating skin wrinkles and/or skin atrophy
    Patent number: 5811413
    Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
    Type: Grant
    Filed: December 16, 1996
    Date of Patent: September 22, 1998
    Assignee: The Procter & Gamble Company
    Inventors: Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
  • Method of administering of a hyaluronic acid and an NSAID to decrease side effects of the NSAID
    Patent number: 5811410
    Abstract: A method of administering a medicinal agent and an effective amount of a form of hyaluronic acid for decreasing side effects associated with using the agent alone in treating a disease or condition in mammals is disclosed. The agent may be a non-steroidal anti-inflammatory drug (NSAID). The amount of hyaluronic acid is sufficient enough to provide a dosage greater than 200 mg/70 kg person. The molecular weight of the form of hyaluronic acid may be less than 750,000 daltons.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 22, 1998
    Assignee: Hyal Pharmaceutical Corporation
    Inventors: Rudolf Edgar Falk, Samuel S. Asculai
  • Composition for treating acne
    Patent number: 5811101
    Abstract: A composition for treating acne and related skin conditions which contains salicylic acid and aloe vera which is improved by the addition of an effective amount of a methylxanthine. Preferably, the methylxanthine is derived from mate extract. A method for treating acne with the composition is also provided.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: September 22, 1998
    Assignee: Waltman Pharmaceuticals Incorporated
    Inventor: Herschel Waltman
  • Compositions for regulating skin wrinkles and/or skin atrophy
    Patent number: 5804572
    Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: September 8, 1998
    Assignee: The Procter & Gamble Company
    Inventors: Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
  • Therapeutic composition and method for treating skin using Centipeda cunninghami extract
    Patent number: 5804206
    Abstract: An extract from the Centipeda genus is obtained by a successive extraction process using varying concentrations of aqueous-ethanol solvents. The resulting extract is effective in the treatment of various skin disorders including the relief of itching and dry skin from psoriasis. The extract also has antiinflammatory, antiallergetic, sunscreen and cell renewal properties.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: September 8, 1998
    Assignee: Bio-Botanica, Inc.
    Inventors: Frank S. D'Amelio, Youssef W. Mirhom
  • Topical product formulations containing strontium for reducing skin irritation
    Patent number: 5804203
    Abstract: Topical formulations comprising an anti-irritant amount of aqueous-soluble strontium (Sr.sup.2+) cation, and method for using the same to inhibit skin irritation are disclosed.
    Type: Grant
    Filed: June 20, 1996
    Date of Patent: September 8, 1998
    Assignee: Cosmederm Technologies
    Inventors: Gary S. Hahn, David O. Thueson, Timothy W. Quick
  • Use of salicylic acid for regulating skin wrinkles and/or skin atrophy
    Patent number: 5801163
    Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: September 1, 1998
    Assignee: Richardson-Vicks Inc.
    Inventor: Roy Lonnie Blank
  • Use of salicylic acid for regulating skin wrinkles and/or skin atrophy
    Patent number: 5795879
    Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
    Type: Grant
    Filed: February 26, 1997
    Date of Patent: August 18, 1998
    Assignee: Richardson-Vicks Inc.
    Inventor: Roy Lonnie Blank