Abstract: A method for increasing the number of capillaries in damaged skin during healing of the skin is disclosed. The method includes the application of a skin composition to the damaged skin which comprises an active compound having peripheral vasokinetic activity and a pharmaceutically acceptable carrier. The active compound is selected from compounds such as Amni visnaga coumarins, Vinca alkaloids, Ergot alkaloids, polyunsaturated fatty acid derivatives, a buflomedil bioflavinoid, Ginkgo bioflavonoids, and Cratageus bioflavonoids. The composition is applied in amount to increase the number of capillaries in new tissue which forms during healing of the damaged skin. Furthermore, a method of treating bedsores is also disclosed.
Type:
Grant
Filed:
December 12, 1996
Date of Patent:
August 18, 1998
Assignee:
Indena S.p.A.
Inventors:
Ezio Bombardelli, Sergio Curri, Giancarlo Guglielmini, Paolo Morazzoni, Walter Polinelli
Abstract: The present invention provides therapeutic conjugates which comprise a therapeutic compound bound to one to three acyl groups derived from fatty acids. The therapeutic compounds are preferably non.about.steroidal anti.about.inflammatory agents which include a carboxylic acid group. The compounds involve the use of tromethamine or ethanolamine derivative to link the acyl groups derived from fatty acids to the therapeutic compounds.
Type:
Grant
Filed:
April 12, 1996
Date of Patent:
August 11, 1998
Assignee:
Commonwealth Scientific and Industrial Research Organisation
Inventors:
Robert George Whittaker, Veronika Judith Bender, Wayne Gerrard Reilly
Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Type:
Grant
Filed:
August 29, 1997
Date of Patent:
August 4, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Type:
Grant
Filed:
August 29, 1997
Date of Patent:
July 28, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
Abstract: The present invention relates to a method for the treatment and protection of human and animal skin which contains vitamin E in a high dose and, in addition, may optionally further contain vitamin C, vitamin A, vitamins of the B series, blood circulation-promoting agents and/or vasodilators, phospholipids, unsaturated fatty acids and/or emulsifiers.
Abstract: Pharmaceutical preparations for the local treatment of inflammations are claimed herein, characterized in that they contain as the active ingredient one or two compounds of general Formula I ##STR1## wherein X is an oxygen atom or a methylene group,R.sub.1 and R.sub.2 represent a hydrogen atom or a hydrocarbon residue of maximally eight carbon atoms, optionally interrupted by an oxygen atom,R.sub.3 is a hydrogen atom or a hydrocarbon residue of maximally eight carbon atoms, optionally substituted by an oxo group, andR.sub.4 is a hydrogen atom or an alkyl group of maximally four carbon atoms.
Type:
Grant
Filed:
November 17, 1994
Date of Patent:
July 21, 1998
Assignee:
Schering Aktiengesellschaft
Inventors:
Walter Klose, Gerald Kirsch, Andreas Huth, Wolfgang Froehlich, Henry Laurent
Abstract: Vitamin B12 is used to stimulate heme oxygenase production. In turn, levels of the molecules 12(R)-HETE and 12(R)-DIHETE, which are arachidonic acid derivatives, are reduced. Various topical formulations containing vitamin B12, but no other vitamins, are described.
Type:
Grant
Filed:
April 3, 1997
Date of Patent:
July 21, 1998
Assignee:
Hemogen, Inc.
Inventors:
Richard D. Levere, Nadar G. Abraham, Michal L. Schwartzman, Michael W. Dunn
Abstract: In the present invention, pharmaceutical compositions containing a histamine-added gamma-globulin as an effective component are used as an immunomodulating agent, a suppressive agent for eosinophilia, and as an antiinflammatory agent. The immunomodulating action is unexpectedly different from the action of conventional immunosuppressive agents. Accordingly, the compositions are useful as a pharmaceutical agent for the therapy of diseases associated with an abnormal immune system such as chronic articular rheumatism, systemic lupus erythematosus, multiple sclerosis, etc. and various types of immunodeficiency syndromes. In addition, the pharmaceutical compositions exhibit suppressive action upon hypereosinophilicity. They may be used as a therapeutic agent for infectious diseases, parasitic diseases, respiratory diseases, autoimmune diseases and eosinophilia caused by malignant tumors. The compositions are excellent antiinflammatory agents.
Abstract: Active compound combinations comprising a combination of at least one substance chosen from the group consisting of 2,4-O-furfurylidenesorbitol and alkyl ethers thereof and at least one substance chosen from the group consisting of tocopherols and tocopheryl esters, and cosmetic and dermatological light protection formulations comprising such active compound combinations.
Type:
Grant
Filed:
February 8, 1996
Date of Patent:
July 14, 1998
Assignee:
Beiersdorf AG
Inventors:
Heinrich Gers-Barlag, Anja Muller, Gerhard Sauermann, Beate Uhlmann
Abstract: Variously pure ribosomal fractions separated from at least one nonphotosynthetic filamentous bacterium are well suited for formulation into a variety of cosmetic/pharmaceutical compositions, for example for the immunostimulation of the immune system of the skin.
Type:
Grant
Filed:
September 30, 1996
Date of Patent:
July 14, 1998
Assignee:
Societe L'Oreal S.A.
Inventors:
Nathalie Pineau, Lionel Breton, Richard Martin
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Type:
Grant
Filed:
August 29, 1997
Date of Patent:
July 14, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: A cosmetic or dermatological composition containing a mixture of at least one type-III ceramide in the form of a single stereoisomer and of at least one type-V ceramide. This mixture is in particular a mixture having a melting point which is much lower than that of the type-III ceramide. This composition is intended in particular for moisturizing dry skins.
Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Type:
Grant
Filed:
December 16, 1996
Date of Patent:
July 7, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
Abstract: In accordance with the present invention, a comfort strip for a razor is provided which topically applies one or more alpha-hydroxy acids or derivatives thereof to the skin surface being shaved. In the preferred practice of the invention, the alpha-hydroxy acid or derivative thereof is incorporated within the water-soluble phase of a comfort strip affixed to a wet shave razor which allows for direct delivery to the skin during the wet shaving process.
Type:
Grant
Filed:
January 17, 1997
Date of Patent:
July 7, 1998
Assignee:
Warner-Lambert Company
Inventors:
Nicholas Perricone, William Vreeland, Fred Wexler
Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Type:
Grant
Filed:
December 16, 1996
Date of Patent:
July 7, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
Abstract: Compositions for inhibiting the formation of unwanted skin pigmentation combine high tyrosinase blocking capabilities with stability in cosmetic preparations, absence of significant cytotoxic effects and synergy of action. The active components of the compositions include extracts of certain selected plants, namely, mulberry, saxifrage, grape and scutellaria root; and, preferably, ethylenediaminetetraacetic acid (EDTA). These ingredients are combined with various cosmetically acceptable carriers to produce cream and lotion formulations capable of whitening skin safely and effectively.
Abstract: Disclosed are topical anti-inflammatory compositions containing 0.1% to 10% by weight of a monogalactosyl dieicosapentaenoyl glycerol having esterified eicosapentaenoic acid residues (MGDG-EPA); anti-inflammatory compositions are formulated using a purified microalgal lipid preparation containing 30% to 100% by weight of MGDG-EPA; methods of making the microalgal lipid preparation; methods of treating inflammation by administering the topical anti-inflammatory compositions to a subject in need thereof.
Abstract: A new Burn Treatment Composition which provides healing to the skin of people who have received burns or are afflicted with other skin complications that require healing. The inventive device includes effective amounts of Chinese rhubarb; calcium hydroxide; sanguisorba officinalis rhizome; common camphor; coptis chinensis rhizome; phellodendron amurense bark and oldenlandia diffusa roxd.
Abstract: Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
Type:
Grant
Filed:
January 22, 1996
Date of Patent:
June 9, 1998
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: An improved method for suppressing xenograft rejection in a host subject is disclosed. The method includes administering an immunosuppressant drug, where the drug or the amount of drug administered is, by itself, ineffective to suppress xenograft rejection. Effective xenograft suppression is achieved by also administering an ethanolic extract of Triterygium wilfordii or a purified triptolide component thereof.
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: Pharmaceutical preparations for controlling proliferation of ectodermally-derived tissues comprising the specific negative growth factor activin A or an agonist thereof, and their use in methods of treatment of proliferative conditions and wound repair.
Type:
Grant
Filed:
February 7, 1995
Date of Patent:
May 19, 1998
Assignee:
Yissum Research Development Co. of the Hebrew University of Jerusalem
Abstract: The use of ginsenoside R.sub.0 or a plant extract containing same to prepare a cosmetic or pharmaceutical composition, particularly a skin care composition, for promoting collagen synthesis, particularly collagen I and/or collagen III synthesis. Said cosmetic or pharmaceutical composition is administered to a mammal, particularly a human being, in order to promote collagen synthesis. A method for promoting collagen synthesis in fibroblast growth media is also disclosed.
Type:
Grant
Filed:
September 18, 1996
Date of Patent:
May 5, 1998
Assignee:
L.V.M.H. Recherche
Inventors:
Alain Meybeck, Frederic Bonte, Marc Dumas, Catherine Chaudagne
Abstract: The present invention relates to a ketoprofen liposome gel and a process for its preparation which is distinguished by a simple method of preparation by spontaneous formation of liposomes from phospholipids and ketoprofen.
Type:
Grant
Filed:
October 13, 1995
Date of Patent:
April 21, 1998
Assignee:
Bayer Aktiengesellschaft
Inventors:
Silvana Ciceri, Hans-Jurgen Hamann, Ingrid Hurner, Peter Kurka, Joachim Maasz
Abstract: The present invention relates to novel veterinary topical compositions, methods of making the compositions, and methods of using the compositions in the treatment of bone, muscle and connective tissue injuries, as well as respiratory ailments, in animals, particularly horses, dogs, and goats. The compositions comprise isopropyl alcohol, mercuric chloride and dimethylsulfoxide (DMSO), and may further comprise herbs. Light training can typically be resumed beginning about 24 hours after applying the composition to the injured area of the animal.
Abstract: A method for reducing the inflammatory response in tissues of a patient, by contacting the tissue with an effective, inflammation-reducing amount of a liquid or gaseous fluorocarbon.
Type:
Grant
Filed:
November 22, 1995
Date of Patent:
March 31, 1998
Assignee:
Alliance Pharmaceutical Corp.
Inventors:
Bradley Phillip Fuhrman, Stephen F. Flaim, Lynn Joanne Hernan, Frances Darey Nesti, Michele Cecile Papo, David Marc Steinhorn
Abstract: A method is provided to treat and/or prevent seborrheic dermatitis of the scalp and other hair bearing areas, dandruff or psoriasis by topically applying to the skin and washing the skin in a shampoo containing an effective amount of a treatment composition containing chloroxylenol, preferably by daily application in a pharmaceutically acceptable vehicle at a concentration of from 0.1 to five (5) percent by weight, preferably about one (1) percent by weight.
Abstract: The present invention relates to topical formulations containing a gel or suspension obtainable by treatment of suitable pulverized minerals with aqueous solutions. The compositions of the invention can be used for the topical treatment of degenerative diseases of cartilage, and of skin damage due to ageing or exposure to electromagnetic radiation, associated with free radicals. The compositions of the invention find application in dermatology, physiotherapy and for cosmetic skin treatments.
Abstract: A pharmaceutical composition of water, water soluble vinyl polymer gel, amine alcohol dispersant and IEP is used topically to treat herpes labialis and aphthous stomatitis lesions, and also to treat herpes genitalis, chicken pox, allergic conjunctivitis, giant papillary conjunctivitis, stomatitis secondary to chemotherapy, thermal burn, sunburn, decubitus ulcers and shingles.
Abstract: In a method for the prevention and/or treatment of skin damage, particularly inflammation and aging, a composition containing lipoic acid and/or a lipoic acid derivative is topically applied to affected skin areas. A fat-soluble fatty acid ester of ascorbic acid such as palmityl ascorbate and/or tocotrienol is preferably applied with the lipoic acid or derivative in association with a dermatologically acceptable carrier.
Abstract: A composition for topical application to human skin in order to promote the repair of photo-damaged skin and/or to reduce or prevent the damaging effects of ultra-violet light on skin and/or to lighten the skin comprising retinol or a derivative thereof and a dioic acid.
Type:
Grant
Filed:
March 11, 1996
Date of Patent:
January 6, 1998
Assignee:
Unilever Patent Holdings B.V.
Inventors:
Clive Roderick Harding, Caroline Marian Lee, Ian Richard Scott
Abstract: Topical compositions for the treatment of corns, calluses and warts comprising a benzenediol or a substituted 1,2-benzenediol and a pharmaceutically acceptable carrier, are described.
Type:
Grant
Filed:
February 12, 1996
Date of Patent:
December 30, 1997
Assignee:
Schering-Plough HealthCare Products, Inc.
Abstract: An antimicrobial composition for application to exposed wounds such as burns and ulcers includes a quaternary ammonium compound blend, a stabilizer, a nonylphenol polyethylene glycol ether, a hydrophilic polymer, sodium lithium magnesium silicate, a hydrophobic waterproofing agent, aluminum sulfate, triethanolamine and water.
Type:
Grant
Filed:
July 26, 1995
Date of Patent:
December 16, 1997
Assignee:
International Laboratory Technology Corp.
Abstract: Cosmetic and/or dermatological compositions containing a non-photocatalytic metal oxide and tocopherol and, optionally, a metal-inactivating complexing agent are effective for inhibiting the light-induced peroxidation of lipids, and in particular lipids of sebaceous origin such as squalene.
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: A method is provided for treating a hypersensitivity disease comprising parenterally administering to a human afflicted with such a disease an amount of an anionic polymer effective to counteract the symptoms of a disease selected from the group consisting of bronchial asthma, eosinophil-associated nasal inflammation and vernal conjunctivitis, by counteracting the effect of at least one cationic toxin released by the eosinophils of said human.
Abstract: Aminoalcohols N-acyl derivatives useful in the prevention and in the treatment of mammalian pathologies induced by mast cell degranulation in consequence of peripheral nerve noxae.
Type:
Grant
Filed:
October 21, 1994
Date of Patent:
October 21, 1997
Assignee:
Lifegroup S.P.A.
Inventors:
Francesco Della Valle, Silvana Lorenzi, Federica Della Valle
Abstract: A hair treatment solution capable of acting as a cosmetic, reducing alopecia, eliminating alopecia, increasing hair growth or any combination thereof is disclosed. The hair treatment solution comprises garlic powder, brewer's yeast, grapefruit juice, acetic acid and kelp. In one aspect, the invention includes a method of applying the hair treatment solution. Typically, the solution is applied directly to a treatment area.
Abstract: The present invention features saponin containing enteral formulations for treatment of infection and inflammation. These saponin containing formulations are particularly useful in conjunction with oils rich in .omega.3 polyunsaturated fatty acids such as fish oils and flax oil but also show benefits with .omega.6 rich oils such as borage oil, black currant seed oil, canola oil and rapeseed oil. These formulations may also contain a lignan from the sesamin family.
Type:
Grant
Filed:
March 7, 1995
Date of Patent:
October 7, 1997
Assignee:
Beth Israel Deaconess Medical Center, Inc.
Abstract: A method for reducing the itch and the scarring associated with chicken pox is disclosed. The method entails applying a topical pharmaceutical formulation of papain, pancreatin or subtilisin to the skin proximate to the vesicles. To further reduce scarring, an antibiotic is applied with the papain, pancreatin or subtilisin. Compositions are provided in the form of solutions, lotions, ointments and salves containing papain, pancreatin or subtilisin and, optionally, a surfactant, an antibiotic and a penetration enhancer.
Abstract: Quercetin and/or naringenin in combination with either retinol or retinyl ester resulted in a synergistic inhibition of keratinocyte differentiation. The effects of the retinol or retinyl esters in combination with naringenin and/or quercetin were analogous to treatment with retinoic acid.
Type:
Grant
Filed:
September 27, 1996
Date of Patent:
September 9, 1997
Assignee:
Chesebrough-Pond's USA Co., Division of Conopco, Inc.
Inventors:
Allan Robert Burger, Stewart Paton Granger, Ian Richard Scott
Abstract: Prophylactic and therapeutic agents for the prevention and treatment of viral-induced tumors and, in particular, compositions derived from an Aspergillus fermentation extract, and the use thereof, either directly or to prepare a medicament, for the prevention and treatment of viral-induced tumors in mammals. Such tumors include papilloma-induced tumors. The composition is topically administered.
Abstract: Prophylactic and therapeutic agents for the prevention and treatment of viral-induced tumors and, in particular, compositions derived from an Aspergillus fermentation extract, and the use thereof, either directly or to prepare a medicament, for the prevention and treatment of viral-induced tumors in mammals. Such tumors include papilloma-induced tumors. The composition is topically administered.
Abstract: Antimicrobial compositions useful in the treatment of microbial infections and as general cleansers are provided along with methods for their administration. The antimicrobial compositions are aqueous based and preferably contain a quaternary ammonium compound as a antimicrobial agent. The antimicrobial compositions also preferably contain a surfactant such as a cationic, nonionic, or amphoteric surfactant or mixtures thereof. A keratolytic agent, such as allantoin, is also preferably blended into the antimicrobial compositions. The antimicrobial compositions are ideally suited for subcutaneous, cutaneous, or mucosal membrane administration.
Abstract: The present invention pertains to therapeutic bioadhesive-wound healing compositions useful for treating wounds and increasing the proliferation and resuscitation rate of mammalian cells. The compositions comprise a bioadhesive agent and a therapeutically effective amount of a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic bioadhesive-wound healing compositions may further comprise medicaments such as antiviral agents, antikeratolytic agents, anti-inflammatory agents, antifungal agents, antibacterial agents, immunostimulating agents, and the like. The bioadhesive-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the bioadhesive-wound healing compositions and the pharmaceutical products in which the compositions may be used.
Abstract: Typical treatment of psoriasis and other diseases of skin cell hyperproliferation using pharmaceutical compositions containing mono-, di, and tri-phosphate esters of antiproliferative nucleoside analogs and related analogs, DNA chain-terminating dideoxynucleosides and other nucleoside analogs. The useful phosphate esters include phosphoramidates and phosphothiorates, as well as polyphosphates having C and S bridging atoms.