Abstract: Vaccines are provided which are composed of (a) non-toxic and highly effective adjuvants obtained from microbial sources, together with (b) tumor antigens. A wide variety of antigens can be employed in the vaccines and include, antigens obtained from tumors or cultures of tumor cells, such as ovarian cancers, melanomas, colorectal cancers, pancreatic cancers, renal cancers and the like. By adding tumor antigens to potent but non-toxic immunostimulants, a protective and lasting tumor immunity can be obtained.

Abstract: A stabilized delayed release emulsion comprising:(a) a lipophilic external phase, and(b) a hydrophilic phase having incorporated therein:(i) a pharmaceutically active ingredient, said pharmaceutically active ingredient being substantially insoluble in said lipophilic phase; and(ii) a gelling agent; anda process for preparing same are disclosed.

Abstract: Cosmetic composition containing hydroxylated chalcone derivatives and its use for protecting the skin and the hair against luminous radiations, new hydroxylated chalcone derivatives employed and process for their preparation.The invention relates to a cosmetic composition for protecting the skin and the hair against UV rays comprising, in a cosmetically acceptable substrate, at least one derivative of 2-hydroxychalcone of formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 denote, independently of each other, a hydrogen atom, a straight- or branched-chain C.sub.1 -C.sub.12 alkyl group, a straight- or branched-chain C.sub.1 -C.sub.12 alkyl group or a straight- or branched-chain C.sub.2 -C.sub.20 acyloxy group.The invention also relates to new derivatives of 2-hydroxychalcone and the process for their preparation.

Abstract: The invention relates to a biocidal fine powder with increased biocidal activity and an agricultural suspension containing the biocidal fine powder and an adjuvant selected from the group consisting of polyoxyalkylene-type nonionic surface active agents and polyoxyalkylene alkyl or alkylaryl ether phosphates or their salts.

Abstract: The invention relates to a process and apparatus for continuous manufacture of an emulsion.A first liquid is brought to emulsion temperature and the components in suspension in the first liquid are brought to the state of second liquids able to be introduced into the first liquid. The components are brought in proportion in liquid form by means of a melting pot-dosimeter and maintained at the temperature of emulsion. The emulsion is carried out in an emulsion vat.Application to the pharmaceutical, food and chemical industries.

Abstract: Disclosed is a novel cosmetic powder composition exhibiting superior smoothness and adhesion to the skin, comprising in its preferred version a combination of ultrafine silica, talc coated with acylamino acid, sericite, polyethylene, and a novel binder comprising a combination of polydimethylsiloxane, distearyl malate and pentahydrosqualene.

Abstract: A stable, water dispersible petroleum jelly formulation, which is an oil-in-water emulsion, is described which comprises water, petroleum jelly, optional humectant, and emulsifier. The composition is formed by ultrasonically emulsifying the various components which will ultimately form the emulsion.

Abstract: A polyene antibiotic emulsion formulation comprising a therapeutically effective amount of the antibiotic incorporated into an oil-in-water emulsion, and a method of treating an active infection in an animal caused by a microorganism with sterols in its cell membrane by parenterally administering the emulsion formulation to such animal.

Abstract: Cosmetic Base composition exhibiting therapeutic properties includes an acyl fatty acid lactylate ester or alkali metal salt thereof, a sucrose fatty acid ester, and a solvent.

Abstract: Lipid emulsion form compositions have been formulated and presented to eliminate adverse injection site reactions associated with the intravenous administration of certain sparingly water soluble, hydrophobic, ionizable drugs in mammals and to provide a solubilized drug form for oral, parenteral or intraarticular administration which enhances drug absorption and the therapeutic efficacy of the drug.

Abstract: A cosmetic composition is disclosed containing, as an agent for protection against light radiation, at least one 2-hydroxydibenzoylmethane of the formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently of one another denote hydrogen or halogen atoms, a straight-chain or branched-chain C.sub.1 to C.sub.12 alkyl group or a C.sub.1 to C.sub.4 lower alkoxy group and R denotes a hydrogen atom or a C.sub.1 to C.sub.4 lower alkyl group, in a cosmetically acceptable medium.

Abstract: A method of treating, and a diet composition for treating patients needing a controlled diet, wherein C.sub.12 fatty acids are the primary fatty acid source. Preferably lauric fats constitute 33-80% of the diet, while LCT's constitute no more than 20%. The lauric fats may be derived from a natural or fractionated kernel oil, selected from a group consisting of babassu oil, coconut oil, cohune oil, palm kernel oil, and tucum oil. A lipid emulsion with diverse additives is described.

Abstract: Foamable cosmetic creams for application onto the skin, comprising a selected creamy oil-in-water emulsion and a selected propellant, which may be and advantageously is a single propellant gas, are disclosed. Improvement of the froth properties is effected by predetermined control of the ingredients of the composition and their proportions, comprising specific percentage ranges of nonionic emulsifier, oil portion, consistency-providing agent, and water, a viscosity of the starting cream emulsion formed therefrom between about 200 and 500 mPas, and the propellant employed, which consists essentially of nitrous oxide or carbon dioxide, preferably nitrous oxide.

Abstract: A highly immunogenic aqueous vaccine formulation adjuvanted with a saponin and an oil.

Abstract: A pharmaceutical formulation for the parenteral, in particular intravenous, administration of sparingly soluble substances is obtained when the very finely ground substance, with a maximum particle diameter of 3 .mu.m, is dispersed in an oil phase which contains emulsifier, and this mixture is emulsified with water for injection, is rendered isotonic and is homogenized using a high-pressure homogenizer, so that the resultant product is a solid/liquid/liquid disperse system.

Abstract: A solvent-free oil-in-water emulsion of propetamphos comprising(a) 5 to 50% by weight of technical propetamphos in the form of droplets having a particle size of below 5 micron,(b) 1 to 8% by weight of a polyvinyl alcohol,(c) 1 to 3% by weight of a buffer, buffering the pH of the formulation to pH 6 to 7,(d) 1 to 2% by weight of a vegetable oil,(e) 0.5 to 2% by weight of an emulsifier(f) 0 to 8% by weight of an antifreezing agent(g) 0 to 0.1% by weight of an antifoaming agent (h) 0 to 0.1% by weight of a perfume,the balance being water, and a process of preparing such emulsion.

Abstract: An oily ointment comprising(a) 0.01 to 0.5% by weight of hydrocortisone butyrate propionate,(b) 2 to 10% by weight of a mixture of propylene glycol and purified water in a weight ratio of from 1:5 to 20:1,(c) 0.1 to 6% by weight of a surface-active agent, and(d) 75 to 97% by weight of a higher paraffinic hydrocarbon.

Abstract: An oil-in-water type cream comprising(a) 0.01 to 0.5% by weight of hydrocortisone butyrate proponate,(b) 5 to 50% by weight of a higher paraffinic hydrocarbon,(c) 3 to 15% by weight of a surface-active agent,(d) 30 to 65% by weight of purified water,(e) not more than 20% by weight of a monohydric higher alcohol,(f) not more than 20% by weight of a dihdyric or trihydric alcohol, and(g) a pharmaceutically acceptable acid in an amount required to adjust the pH of the cream to a value in the range of 3.5 to 6.5 when it is diluted with water to 20 times its volume.

Abstract: This disclosure describes quick breaking, in vivo, intravenous, intramuscular, intraarticular fat emulsion compositions which incorporate the use of benzyl alcohol as a consurfactant and/or a cosolvent in combination with materials such as synthetic surfactants, e.g. sorbitan triisostearate, triglycerol diisostearate or triglycerol pentaoleate; naturally occurring vegetable oils, e.g. sesame oil, and soybean oil; natural lecithins such as egg lecithin or soy lecithin; saturated or unsaturated aliphatic acids, e.g. oleic acid, hexanoic acid and linolenic acid; and other excipients such as glycerine, polyvinylpyrrolidone, Pluronic.RTM. F-68 and di-.alpha.-tocopherol.

Abstract: Skin treatment compositions such as sun screen compositions and moisturizer compositions are provided which include polyglyceryl-8 oleate to impart moisture resistance or substantivity to the compositions.

Abstract: A composition comprising; (A) a basic amino acid salt of a higher aliphatic phosphate represented by the following formula (I): ##STR1## in which R.sub.1 is an alkyl or alkenyl group having from 12 to 22 carbon atoms, and (B) an .alpha.-monoalkyl glyceryl ether represented by the following formula (II): ##STR2## in which R.sub.2 is an alkyl group having from 12 to 24 carbon atoms. The composition provides an O/W type emulsion suitable for use as cosmetics which has a small viscosity decrease at a high temperature and a small viscosity increase at a low temperature, is stable during storage over a long period of time, provides good feelings and a moisture retaining effect on use to the skin, and yet has an excellent safety.

Abstract: A two-phase liquid cosmetic composition is provided comprising an oil phase, an organic liquid/water phase, and insoluble solid particles absorbed on the interface between the two phases wherein the solid particles comprise the in situ precipitation product of at least first and second salt solutions added to the oil phase and organic liquid/water phase during blending thereof. The insoluble salt precipitates facilitate dispersion of the oil phase in the form of "spheres" or "droplets" within the organic liquid/water phase thereby producing a liquid cosmetic having an aesthetically desirable appearance.

Abstract: A dosage form that coadministers a drug and two percutaneous adsorption enhancers to a defined area of the skin is described. The dosage form comprises a body that contains supplies of drug and enhancers and has a basal surface that contacts the area of skin and transmits the drug and enhancers to the area for absorption thereby.

Abstract: An oil-in-water emulsion and method for forming same, containing as the primary emulsifier, a palmitic acid soap and a stearic acid soap, in a palmitic:stearic weight ratio of 1:025-0.67.

Abstract: The invention relates to topical antiinflammatory medicament formulations which also have analgesic activity and contain 2-(2-hydroxyethoxy)-ethyl N-(.alpha.,.alpha.,.alpha.,-trifluoro-m-tolyl) anthranilate as the active ingredient and an adjuvant which is preferably a triglyceride.

Abstract: The invention relates to liquid, transparent, multicomponent systems for use in pharmaceutical products for cutaneous, peroral, vaginal and parenteral administration of pharmaceutical active agents. The multicomponent systems according to the invention contain the active agents in a solution of an oily and optionally an aqueous component in the presence of certain physiologically acceptable surfactants and cosurfactants. Under certain conditions, the cosurfactants can serve as oil components or the latter can optionally take over the cosurfactant function. The biological availability of the active agents applied in the form of the multicomponent systems according to the invention is much better than that of active agents applied in the form of known multicomponent systems.

Abstract: A stable W/O/W type multiple emulsion containing very fine water droplets and suitable for use in the production of foods, cosmetics and medicines is prepared by using a glycerol unsaturated fatty acid ester as an emulsifier for a W/O emulsion.

Abstract: A detergent composition for cleaning hair and skin is a mixture of:(a) a major amount of one or more oils of the group comprising mineral, vegetal, animal and synthetic oils, and(b) a minor amount of at least one emulsifying agent, preferably a mixture of emulsifying agents, one of which is a saccharose ester,whereby cleaning action is improved while a protecting lipid layer is left onto the skin. The composition may also contain a bentonite or montmorillonite clay to improve the hydrating and restoring effects thereof.

Abstract: A polyene antibiotic emulsion formulation comprising a therapeutically effective amount of the antibiotic incorporated into an oil-in-water emulsion, and a method of treating an active infection in an animal caused by a microorganism with sterols in its cell membrane by parenterally administering the emulsion formulation to such animal.

Abstract: Anhydrous emulsion with an oil phase (o) and a hydrophilic phase (p) of water-soluble, but anhydrous liquids, particularly as a filler matrix for medicinal preparations in capsules, which on the one hand does not attack the capsule wall and on the other permits an excellent active agent release.

Abstract: This invention relates to novel water in oil emulsions. The emulsions of this invention are translucent water in oil emulsions comprising a water phase containing a humectant, an oil phase comprising petroleum jelly and the like and an emulsifying agent to give a water in oil emulsion; the aqueous phase having a refractive index in essentially the same range as the oil phase.The translucent water in oil of this invention have the same general appearance and feel of petroleum jelly and function like petroleum jelly but are superior thereto in the sense that when applied to skin will not only help prevent water from escaping therefrom or exist a barrier effect, but also, will allow water humectants and other moisturizers from the emulsion water phase to pass therethrough to contact the skin and to moisturize the skin.The compositions of this invention are useful as skin moisturizer compositions. They may be used as a carrier or vehicle for oil and water soluble tropical drugs.

Abstract: Method for providing caloric nutrition via liquid emulsions, to a patient with dysfunctional visceral organ comprising parenterally administering to the patient a lipid emulsion containing from about 10% to 50% by weight of long chain triglycerides and the remaining lipid being medium chain triglycerides.

Abstract: This invention relates to a substitute for mineral oil in toiletry and cosmetics. In particular it relates to blends of esters which match the viscosity and feel of mineral oil. Specifically, it relates to ester blends which include tridecyl trimellitate.Tridecyl trimellitate ("TDTM") is the ester of tridecyl alcohol and trimellitic acid, and has recently been offered for use to the cosmetics industry.It has surprisingly been found that by blending tridecyl trimellitate with other esters, the viscosity and feel of mineral oil can be matched, the resulting product being a substitute for mineral oil in toiletry and cosmetic compositions.

Abstract: A pharmaceutical oil-in-water type micro-emulsion comprising fine particles of an oil or fat containing an effective amount of a 4-biphenylylacetic acid ester of the formula ##STR1## wherein R represents an alkyl group, an aqueous medium and a physiologically acceptable emulsifier for dispersing said fine particles in said aqueous medium.This micro-emulsion is useful for treating inflammation, pain and/or fever in a mammal.

Abstract: Troublesome foaming in the fermentation of yeast is suppressed by the addition of polyglycol ethers which are derived from saturated and monounsaturated C.sub.16 -C.sub.18 fatty alcohols and which contain on an average of from 1 to 4 ethylene and/or propylene glycol ether groups. Preferred defoamers contain oleyl and cetyl alcohol residues in a ratio of from 3:1 to 1:1, and on average 2 ethylene glycol ether groups. The defoamers do not inhibit yeast growth or lead to premature softening and liquefaction of the compressed yeast.

Abstract: Local anesthesia is induced using microdroplets of a general anesthetic in liquid form. As an example, microdroplets of the general anesthetic methoxyfluorane coated by a unimolecular layer of dimysistoyl phosphatidylcholine are prepared by sonication. The microdroplets so prepared remain stable in physiologically-compatible solution, and are suitable for injection, typically intradermally or intraveneously, into a patient for inducing local anesthesia. These methoxyflurane-containing microdroplets have been demonstrated to cause long-term local anesthesia when injected intradermally, giving duration of anesthesia 28 times longer than with other anesthetics, such as lidocaine and 11 times longer than with bupivacaine.

Abstract: A soft capsule containing as active ingredient .gamma.-oryzanol alone or oryzanol in combination with riboflavin butyrate is described. The shelf life of this composition is increased without precipitation of the ingredients thereof.

Abstract: A cosmetic composition for make-up containing an N-acylamino acid salt or Al, Mg, Ca, Zn, Zi or Ti which may contain a pigment and/or an extender pigment treated with one or more of the N-acylamino acid metal salts.

Abstract: Antimony-containing anti-leishmaniasis drugs are encapsulated in a lipid based liposomal formulation having a weight ratio of lipid to encapsulated antimony-containing drug of 1:1.6 to 1:0.25 and a salt concentration in the continuous aqueous phase which is at least isotonic with human blood. Such formulations are found to have a leakage rate of initially encapsulated antimony-containing drug of less than 50% by weight after storage at 25.degree. C. for 6 weeks from encapsulation and hence provide storage stable formulations which can be used effectively after prolonged storage without refrigeration in tropical climates. The anti-parasital activity of the liposomal formulations has been found greater than that of corresponding aqueous formulations.

Abstract: Compositions are disclosed for providing non-greasy, cosmetic moisturizing, conditioning and protective barrier effects on skin and hair, and to a rinse-on method for producing these effects. More particularly the compositions comprise oil-in-water emulsions that are adapted to invert to water-in-oil emulsions at the hair or skin surface when they are rubbed into the skin and hair. The compositions a include water, unctrous oleaginous material, water-dispersible, non-toxic polyvalent metal salt having a cation selected from the group consisting of aluminum (III), cerium (III), iron (III), zirconium (IV), aluminum zirconium coordination complexes, and mixtures thereof and sufficient acid or alkali to provide a pH value of about 1.5 to 7.5.

Abstract: Surface-active statistical oligomers of the formula ##STR1## in which R.sub.1 denotes a C.sub.4 -C.sub.30 optionally substituted, aliphatic or cycloaliphatic radical, R.sub.2 denotes a C.sub.5 -C.sub.20 alkyl radical, m and n, which are identical or different, denote a number from 1 to 25, X denotes --CH.sub.2 --, --O-- or ##STR2## in which u=0 or 1, and Y denotes a group: ##STR3## (in which M denotes a hydrogen atom or an alkali metal or alkaline earth metal), an amine group, an amine salt or ammonium are described as well as processes for their preparation and novel intermediates used in these processes. These surface-active oligomers possess a low aggressiveness towards the skin and mucous membranes and ae suitable for use in cosmetic compositions and for dispersing hydrocarbons.

Abstract: According to the invention, the parenteral administration of water-insoluble pharmacologically active agents is enhanced wherein the agents are administered in the lipoid phase of a carrier emulsion comprising a microemulsion of a finely dispersed lipoid in an aqueous phase. The lipoid preferably has a mean particle size below 1 micron. This makes it possible to administer water-insoluble agents in high concentrations, and thus a lower dose, whereby a rapid onset of the pharmacological effect is accompanied by a markedly reduced incidence of injury to body tissues.