Abstract: A novel composition for antiperspirant aerosol comprises an antiperspirant substance, a silicone-treated clay mineral and an oil substance.When the composition is sprayed over the skin, sweat can readily evaporate immediately after spraying and even after perspiration. Thus, the composition ensures a very good feel in use.

Abstract: An improved salve having medicinal properties and method of preparing the same, said salve comprising olive oil, beeswax, camphor, pine rosin, and anhydrous lanolin.

Abstract: A composition for personal care products comprising alkoxylated polyether derived from C.sub.6 to C.sub.22 fatty alcohol in admixture with cyclic dimethyl siloxane pentamer or tetramer, in a weight ratio 5:95 to 95:5 and their use in oil/water or water/oil emulsions, together with processes for their preparation.

Abstract: An inert, water-immiscible inert organic liquid having gas transport properties, water and a suitable emulsifying agent are formed into a stable gel by emulsifying a mixture of the same, concentrating the emulsion to form a gel phase and a liquid phase and separating the two phases. The resulting gel can be used as an ointment or cosmetic for skin irritations or wounds, or as a coating in industrial applications where extended contact of a surface with a gas, such as oxygen, is desired. Fluorocarbons or low viscosity silicone oils are suitable organic liquid components of the gels.

Abstract: A composition for suppository bases consisting of a water-insoluble fat and an adduct of 5 to 50 mol ethylene oxide with 1 mol hardened castor oil as emulsifier enables suppositories containing aqueous active-principle solutions to be prepared. The emulsifier is preferably present in a quantity of 0.2 to 10% by weight. Suppositories containing up to 30% by weight water dispersed therein can be prepared using the above composition.

Abstract: Disclosed are pharmaceutical compositions comprising sorbohydroxamic acid, or pharmaceutically-acceptable salts thereof, which are useful for topical application to prevent damage to skin caused by acute or chronic UV exposure. Combinations of sorbohydroxamic acid together with tocopherol sorbate and/or sunscreens are also disclosed.Also disclosed is a method for using these compositions topically, prior to UV exposure, to prevent damage to skin caused by acute or chronic UV exposure.

Abstract: A therapeutic method of treating the chronic human superficial fungus infection tinea pedis produced by the pathogenic dermatophytic fungi Microsporum sp., Trichophyton sp., and Epidermophyton sp., which invade and attack keratinized skin areas of the body by repeatedly applying topically to the itching, macerated, cracked, and scaling skin areas of the body at the site of the infection a fungicidally effective amount of a silane-containing lotion antagonistic to the dermatophytic fungi in order to exert at least an inhibitory growth effect upon the dermatophytes.

Abstract: A percutaneous absorption accelerator and a precutaneous absorbent preparation containing the same and, more particularly, a percutaneous absorption accelerator containing ether derivatives of specific glycerols or polyglycerols and alcohols as effective components and a percutaneous absorbent preparation containing the percutaneous absorption accelerators and pharmaceutically effective components.

Abstract: Antioxidant compositions and methods are disclosed that are prepared by the extraction of natural antioxidants from plant substrates.

Abstract: An absorbent prepared by supporting an organic or inorganic reductive substance on hydrated aluminum silicate is useful as a pharmaceutical or as an absorbent for precious metal complexes such as gold complex, silver complex and the like.

Abstract: The present invention provides a composition comprising L-carnitine in a suitable vehicle for topical application in an effective amount. The present compositions are useful in improving or healing skin conditions including wrinkling, dry or peeling skin, and burns (particularly sunburn), and in healing and prevention of scar formation, particlarly that caused by infection by a pathogen. Treatment methods are also provided.

Abstract: Compositions for the transdermal delivery of azatadine and the use of such compositions in the treatment of allergic reactions are disclosed.

Abstract: An aqueous, noncrystalline minoxidil composition for topical use. The composition contains minoxidil complexed with an amphipathic compound having a pK less than about 5 and containing a single lipophilic chain moiety and a sulfate, sulfonate, phosphate and phosphonate polar moiety. The composition may be formulated in ointment form, in an aqueous vehicle, or dispersed in a fluorochlorocarbon solvent, for spray delivery from a self-propelled spray device.

Abstract: Cosmetic Base composition exhibiting therapeutic properties includes an acyl fatty acid lactylate ester or alkali metal salt thereof, a sucrose fatty acid ester, and a solvent.

Abstract: The invention provides an ointment composition for treating skin irritations such as diaper rash and decubitus. The composition includes zinc oxide, boric acid, karaya gum, peruvian balsam, cod liver oil and an appropriate solvent and pharmaceutical carrier.

Abstract: A cosmetic composition is disclosed containing, as an agent for protection against light radiation, at least one 2-hydroxydibenzoylmethane of the formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently of one another denote hydrogen or halogen atoms, a straight-chain or branched-chain C.sub.1 to C.sub.12 alkyl group or a C.sub.1 to C.sub.4 lower alkoxy group and R denotes a hydrogen atom or a C.sub.1 to C.sub.4 lower alkyl group, in a cosmetically acceptable medium.

Abstract: The invention relates to a composition and method of dissolving melanin in a composition for the purpose of photoprotection of the human epidermis from exposure to the sun's harmful rays. The composition consists of melanin, as an active ingredient, sunscreens, vitamins and emollients. These ingredients are rapid blended by ultrasound for 2-3 hours to form a mixture that enhances the sun protective factor when applied topically.

Abstract: Cosmetic screening composition containing a UV screen in combination with a polymer obtained by block polymerization in emulsion and its use for the protection of the human epidermis against ultraviolet radiations.

Abstract: Pharmaceutical compositions which are suitable for topical application in the treatment of bacterial and/or fungal infections are described. The compositions comprise a synergistic mixture of a silver compound and an azole derivative together with a pharmaceutically acceptable carrier therefor. The compositions may be applied topically in the treatment of burns ulcers and other skin lesions, general skin infections and also in the treatment of infections of the mucous membranes. Preferred compositions contain silver sulphadiazine and clotrimazole or metronidazole. The compositions may be applied as ointments, gels, pessaries, tablets and the like.

Abstract: A medicinal preparation for individual prevention of venereal diseases and treatment of urogenital trichomoniasis comprises an efficient quantity of an active principle which is essentially a synergistic mixture of para-nitro-alpha-chlorocinnamic aldehyde of the formula: ##STR1## dimethylsulphoxide and a pharmaceutical excipient. Polyethyleneglycol having a molecular mass of 400 is recommended to be used as the pharmaceutical excipient.A method for treatment of urogenital trichomoniasis consists in application of the medicinal preparation in question to the mucosa of human genitalia in a dose of 1.5 to 10 ml twice a day for 5 to 7 days.

Abstract: Cooling, anti-itch skin preparations in a hydrophilic base, comprising an anti-inflammatory corticosteroid, peppermint oil and urea.

Abstract: An oily ointment comprising(a) 0.01 to 0.5% by weight of hydrocortisone butyrate propionate,(b) 2 to 10% by weight of a mixture of propylene glycol and purified water in a weight ratio of from 1:5 to 20:1,(c) 0.1 to 6% by weight of a surface-active agent, and(d) 75 to 97% by weight of a higher paraffinic hydrocarbon.

Abstract: An oil-in-water type cream comprising(a) 0.01 to 0.5% by weight of hydrocortisone butyrate proponate,(b) 5 to 50% by weight of a higher paraffinic hydrocarbon,(c) 3 to 15% by weight of a surface-active agent,(d) 30 to 65% by weight of purified water,(e) not more than 20% by weight of a monohydric higher alcohol,(f) not more than 20% by weight of a dihdyric or trihydric alcohol, and(g) a pharmaceutically acceptable acid in an amount required to adjust the pH of the cream to a value in the range of 3.5 to 6.5 when it is diluted with water to 20 times its volume.

Abstract: Certain formulations of pseudomonic acids and their salts have good antifungal activity.

Abstract: A novel cosmetic comprises an oil gel formed by at least one metal salt of a dialkyl phosphate of the following general formula (I), (II) or (III) ##STR1## in which each R.sub.1 and each R.sub.2 independently represent a saturated or unsaturated, linear or branched hydrocarbon group having from 8 to 36 carbon atoms, m is an integer of from 1 to 3, n is an integer of from 0 to 2, k is a value of 1 or 2, and 1 is a value of 0 to 1, and a cosmetic oil.The metal salt of the dialkyl phosphate can yield a good oil gel when it is incorporated into the oil in an amount as small as 0.1 to 10% of the oil. Further, the dialkyl phosphate retains good feel of oils without causing oozing of the oil, crazing, discoloration, perspiration and the like.

Abstract: A pharmaceutical composition for external use with the enhanced penetration of a pharmacologically active agent through the skin or mucosa of a warm-blooded animal, said composition comprising(A) a pharmaceutically effective amount of the pharmacologically active agent, and(B) an optically active or inactive pyroglutamate of the following formula ##STR1## wherein R represents a linear, branched or cyclic alkyl or alkenyl group having 10 to 14 carbon atoms,as a penentration enhancer.

Abstract: The present invention provides silicone-water emulsions formed from volatile cyclic polysiloxanes which are emulsified with a preblended mixture of water and a combination of emulsifying agents. Highly ethoxylated nonionic emulsifying agents are particularly well-suited for the formation of stable silicone-water emulsions from volatile cyclic polysiloxanes. These volatile silicone-water emulsions can be combined with epidermal enhancing agents for cosmetic and medicinal purposes.

Abstract: A combination skin care and shaving composition which essentially contains a phospholipid, wheat germ oil and vitamin E that prevents pseudo folliculitis.

Abstract: A method of enhancing penetration of a drug through the skin or other biological membranes using lecithin is herein described along with pharmaceutical compositions containing effective amounts of lecithin as a penetration enhancer.

Abstract: A lamella type, single phase liquid crystal composition is prepared from a hydrophilic nonionic surfactant, a water-soluble substance having a hydroxyl group in a molecule thereof, an oil substance, and water.Oil-base cosmetic compositions including cleansing compositions, massage creams or drugs for external application are incorporated with the liquid crystal.The compositions are readily washed off simply by water, and exhibit good properties of non-stickiness and long storage stability.

Abstract: Biphenylylpropionic acid derivatives of the formula: ##STR1## wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula: ##STR2## wherein R.sup.1 is a lower alkyl group having 1 to 5 carbon atoms and R.sup.2 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, or a lactone having the formula: ##STR3## wherein R.sup.3 and R.sup.4 are hydrogen atom or a lower alkyl group having 1 to 2 carbon atoms, and n is an integer of 1 or 2. The compounds have excellent anti-inflammatory, analgesic and antipyretic activities. Moreover, the compounds have no irritation, rapid and long-acting, and high safety margin.

Abstract: The invention includes novel pharmaceutical compositions for topical use in the therapy or prophylaxis of inflammatory skin diseases, a method of treating one or more such diseases, a novel, optically active N-substituted-isobutyramide as an active ingredient and a process for the manufacture of said novel active ingredient.

Abstract: A topical antiperspirant composition containing an antihistamine selected from the group consisting of antazoline, pyrilamine, tripelennamine, diphenhydramine, phenindamine and their corresponding pharmaceutically acceptable salts and an enhancer for said antihistamine selected from the group consisting of sodium sulfate, glutamic acid; octyl palmitate and propylene glycol methyl ether.

Abstract: A skin moisturizing preparation, such as a skin cream, face cream, lotion or ointment containing a combination of a phosphatide such as soy lecithin and one or more C.sub.10 -C.sub.30 carboxylic acid sterol esters. The preparation preferably also contains a caprylic/capric acid triglyceride for enhanced moisturization. There is also described a method of treating dry skin by topical application of such moisturizing preparations.

Abstract: The invention comprises compositions for cosmetic skin treatment utilizing the application of heat to the skin. The compositions include between 30 and 70 percent by weight of petrolatum, between 20 and 68 percent by weight of triglycerides, preferably capric, caprylic and stearic triglycerides, and between 0.1 and 5 percent by weight of polyethylene.

Abstract: A process for arresting the proliferation of microorganisms which convert axillary secretions into malodorous materials by treating these axillary secretions with a composition containing a compound selected from the group consisting of tripelennamine, phenindamine, hexylcaine, tetracaine, naphazoline, xylometazoline, pyrilamine and pharmaceutically acceptable salts thereof.

Abstract: Skin treatment compositions are provided which inhibit generation of free radicals in the skin and which include 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, 6-ethoxy-1,2-dihydro-2,2,4-trimethyl quinoline or mixture thereof.

Abstract: Vegetable fatty substance composition for use in cosmetics containing: fatty acid triglycerides 85-94%, fatty acid esters containing 40 carbon atoms 7-14%, vitamins 0.01-1.0%, antioxidant 0.5-1.5% if required.This composition is prepared by malaxing in the heated state, at a temperature not exceeding 50.degree. C., fatty acid triglycerides to which the fatty acid ester is added and after mixing well, the vitamins, and if required, the antioxidant, are added.The fatty substance composition advantageously replaces the animal origin fatty substances in cosmetic compositions.

Abstract: Aromatic heterocyclic derivatives have the formula ##STR1## wherein R.sub.1 represents ##STR2## wherein R.sub.3 represents hydrogen, --OR.sub.4 wherein R.sub.4 represents hydrogen, alkyl having 1-20 carbon atoms or mono- or polyhydroxyalkyl or R.sub.3 represents ##STR3## wherein r' and r" represent hydrogen, lower alkyl or together form a heterocycle, R.sub.2 represents hydrogen or --CH.sub.3 and Ar represents ##STR4## wherein Z is O or S, ##STR5## wherein R.sub.5 is lower alkyl or ##STR6## wherein R.sub.6 is hydrogen or alkyl having 1-10 carbon atoms and R.sub.7 represents alkyl having 4-12 carbon atoms or cycloalkyl, Y is CH or a nitrogen atom and X represents oxygen, sulfur or --N--R.sub.8 when R.sub.8 represents hydrogen, lower alkyl or lower alkoxycarbonyl, with the proviso that (i) when Y is CH and X is oxygen or sulfur Ar is other than C and (ii) when Y is nitrogen and X is oxygen, Ar is other than (C) or (D) in which R.sub.6 is alkyl having 1-4 carbon atoms and R.sub.

Abstract: A new and improved topically applied pharmaceutical preparation for the treatment of itching, rash, eczema, insect bites, poison ivy and the like and an improved vehicle for delivering the active ingredients thereof to the human skin in a manner whereby the bioavailability and percutaneous absorption of the active ingredient is remarkably enhanced. The vehicle comprises a volatile silicone, a fatty alcohol having from 12-22 carbon atoms, hydrocortisone; and such preservatives or emulsifying agents as may be warranted.

Abstract: The invention provides an ointment useful in treating skin irritations and promoting the healing of wounds. The preferred embodiment comprises a mixture of the raw gel of the aloe vera plant with a base, such as Aquaphor. A method for making the ointment composition is also disclosed.

Abstract: Compounds of the formula I ##STR1## where the individual radicals R are identical or different and are each hydrogen, an alkali metal, or ammonium which is unsubstituted or substituted by organic radicals, or are each C.sub.1 -C.sub.20 -alkyl or a polyoxyethylene radical which contains from 1 to 10 ethylene oxide units and whose terminal OH group may be etherified by an alcohol of 1 to 3 carbon atoms, are used as sun screen agents.

Abstract: A method of prophylactics with respect to detoxification of Staphylococcus aureus and other toxins by ascorbic acid, salts and esters, topically applied by means of carriers which are otherwise regularly employed in the area where Staphylococcus aureus or other bacteria colonize, such as a pharmacological appliance including gauze pads, an absorbant mass or pad associated with menses, douches, and contraceptive compositions.

Abstract: A method of prophylactics with respect to deodorization by ascorbic acid, salts and esters, topically applied by means of carriers which are otherwise regularly employed in the vaginal area, such as a pharmacological appliance including gauze pads, an absorbant mass or pad associated with menses, douches, and contraceptive compositions.

Abstract: A composition for treatment of decubitus ulcers comprising an admixture of from about 10 to about 50 parts lecithin, from about 10 to about 50 parts goldenseal root or rhizome, and from about 10 to about 50 parts myrrh gum.

Abstract: A deodorant composition comprises a cosmetically acceptable vehicle containing methyl salicylate and a solubility enhancing oil, preferably peanut oil. The composition is externally applied to the skin, generally to the feet of the user, and provides protection against development of odor.

Abstract: Polyvinyl alcohol polymers having pendant cationic quaternary nitrogen containing groups provide for a film forming moisture barrier in skin conditioning lotions, ointments, cosmetic conditioning treatments and pharmaceutical formulations.

Abstract: Polyvinyl alcohol polymers having oxy-linked pendant quaternary ammonium or tertiary amine groups provide a thin film which aids in reducing moisture loss when applied to skin as conditioning lotions or ointments in cosmetic and pharmaceutical formulations.

Abstract: Aliphatic, aromatic, carbonate, carbamate, or sulfonate ester prodrugs of 3-hydroxymorphinans lack the bitter taste of the parent compounds and provide enhanced bioavailability of 3-hydroxymorphinans from buccal, nasal, and sublingual dosage forms.

Abstract: An antibacterial cream is provided which can be used for topical application in the treatment of burns and other skin disorders. The topical creams of the invention can be used without the need to destroy surface barriers and provide significant penetration into the wound. The creams of the present invention comprise a bacterial agent distributed in a cream base which contains 20-50% of at least one hydrocarbon component and at least one polyol moisturizing component, on a weight to weight basis.