Ointment Or Salve Base Patents (Class 514/969)
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Patent number: 5070107Abstract: Systemic antiviral treatment using a narrow class of aliphatic straight-chain saturated monohydric alcohols which have from 27 to 32 carbons in the chain in physiologically compatible compositions for injection or trans-mucus membrance introduction into humans and other mammals is disclosed.Type: GrantFiled: November 2, 1989Date of Patent: December 3, 1991Assignee: Lidak PharmaceuticalsInventor: David H. Katz
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Patent number: 5069904Abstract: A method of using nicotine in the treatment of various conditions susceptible to alleviation by nicotine therapy such as disease states characterized by reduced central cholinergic function. Nicotine is administered to a subject initially having a blood supply substantially free of nicotine at a dose and for a period sufficient to allow the subject to tolerate the dose and thereafter increasing the dose of nicotine at intervals until a therapeutic dose is achieved. Smokers may also benefit from the treatment regimen.Type: GrantFiled: January 5, 1990Date of Patent: December 3, 1991Assignee: Elan Corporation, PLCInventor: Joseph G. Masterson
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Patent number: 5061700Abstract: Compositions of matter serving as topical ointment vehicles and comprising a glyceryl acetate, preferably triacetin, and an oleaginous material that can be combined with a medicament, preferably a corticosteriod, are described. The glyceryl acetate component functions as a solvent for the medicament. Additionally, methods of use for treating skin disorders comprising the topical application of a therapeutically effective amount of a medicament in a composition of the invention are detailed.Type: GrantFiled: November 16, 1989Date of Patent: October 29, 1991Assignee: Gordon Jay DowInventors: Gordon J. Dow, Debra A. Dow
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Patent number: 5057497Abstract: Absorption of Tissue Respiration Factor (TRF) into the gingival tissues is materially enhanced when it is formulated as a non-astringent hydrophilic pharmaceutical composition containing penetration promoting substances which are both hydrophilic and lipophilic. Additionally, a highly efficient means for effecting absorption of TRF into the gingival tissues is to utilize liposomes as carriers for the TRF in a non-astringent pharmaceutical composition.Type: GrantFiled: July 13, 1989Date of Patent: October 15, 1991Assignee: Calam & Associates, Inc.Inventors: Henry D. Calam, Hans A. Schaeffer
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Patent number: 5051260Abstract: Method and compositions for enhancing the cutaneous penetration of topically or transdermally delivered pharmacologically active agents. The compositions include various urethane compounds as permeation enhancers, the urethane compounds formed from reaction of a monomeric organic diisocyanate with a hydroxy- or hydroxy/alkoxy-terminated linear alkylene or polyalkylene glycol or polyether.Type: GrantFiled: September 20, 1990Date of Patent: September 24, 1991Assignee: The Regents of the University of CaliforniaInventors: Samuel Chess, Jerry L. McCullough, Gerald D. Weinstein
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Patent number: 5047232Abstract: Non-aqueous waterproof oil-based topical compositions containing one or more water-in-oil emulsifiers having an HLB value of about 1 to about 7, e.g., sorbitan sesquioleate, and at least one cosmetic emollient, e.g., extra heavy mineral oil, as well as methods for making such compositions are disclosed. The waterproof compositions are particularly useful as vehicles for non-aqueous waterproof oil-based topical sunscreen compositions.Type: GrantFiled: September 29, 1986Date of Patent: September 10, 1991Assignee: Schering-Plough Healthcare Products, Inc.Inventor: Carl Kaplan
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Patent number: 5041439Abstract: Topical pharmaceutical compositions containing a specific 6-amino-1,2-dihydro-1-hydroxy-2-iminopyrimidine component and a penetration-enhancing vehicle are disclosed. The vehicle comprises a binary combination of a C.sub.3 -C.sub.4 diol or C.sub.3 -C.sub.6 triol and isocetyl alcohol polar lipid compound. The vehicle provides marked transepidermal and percutaneous delivery of the iminopyrimidine compound. These compositions, when applied topically, act to stimulate the growth of mammalian hair on the body.Type: GrantFiled: November 20, 1990Date of Patent: August 20, 1991Assignee: The Procter & Gamble CompanyInventors: Gerald B. Kasting, Ellen R. Massaro, Ronald L. Smith, William E. Snyder
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Patent number: 5039513Abstract: Disclosed are topical compositions comprising sorbohydroxamic acid with a radical scavenging compound which prevent damage to skin caused UV radiation. Also disclosed is a method for using these compositions topically, to prevent damage to skin caused by UV radiation exposure.Type: GrantFiled: August 25, 1989Date of Patent: August 13, 1991Assignee: The Procter & Gamble CompanyInventors: Ranjit U. Chatterjee, Stephen J. Kirchner
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Patent number: 5037640Abstract: Compositions containing selected indoles and m-nitro alkoxybenzenes are useful for imparting a tan coloration to the skin while concurrently functioning as sun screening compositions.Type: GrantFiled: November 22, 1989Date of Patent: August 6, 1991Assignee: Clairol IncorporatedInventors: Thomas M. Schultz, George Serban, Alexander C. Chan
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Patent number: 5034213Abstract: Photostable cosmetic composition containing an ethylrutin derivative as protective agent against sunlight and its use in the protection of the skin and the hair.The invention relates to a photostable cosmetic composition for the protection against UV rays with wavelengths between 280 and 400 nm, which contains an effective quantity of an ethylrutin derivative chosen from amongst tetrahydroxyethylurtin and morpholinoethylrutin, in a cosmetically acceptable aqueous or aqueous/alcoholic medium.The ethylrutin derivative is advantageously combined with a know UV-B or UV-A filter.Application as a sunscreen composition for skin, a protective composition for hair as a light-stabilized cosmetic composition.Type: GrantFiled: May 26, 1989Date of Patent: July 23, 1991Assignee: L'OrealInventors: Georges Rosenbaum, Jean F. Grollier
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Patent number: 5030442Abstract: An aqueous, noncrystalline minoxidil composition for topical use which has significantly improved flux of the drug through human cadaver skin. The composition contains minoxidil complexed with an amphipathic compound, oleic acid and with pharmaceutically acceptable excipients. The composition may be formulated in an aqueous vehicle, or dispersed in fluorochlorocarbon solvent for spray delivery from a self- propelled spray device.Type: GrantFiled: April 4, 1989Date of Patent: July 9, 1991Assignee: Liposome Technology, Inc.Inventors: Paul S. Uster, Yolanda P. Quinn
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Patent number: 5028417Abstract: Novel sunscreen compositions containing titanium dioxide having a particle size less than 10 m.mu. are described as well as methods of protecting the skin from damaging ultraviolet radiation.Type: GrantFiled: July 20, 1987Date of Patent: July 2, 1991Assignee: Johnson & Johnson Consumer Products, Inc.Inventors: Gulguhji R. Bhat, Martin K. O. Lindemann, Prakash Naik-Satam
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Patent number: 5028416Abstract: An external skin care preparation comprising a compound represented by the following general formula (I) or (II), or a salt thereof: ##STR1## wherein R.sup.1 means an aliphatic hydrocarbon group having 9-25 carbon atoms, A and B denote specific groups respectively, R.sup.6 and R.sup.7 are individually an aliphatic hydrocarbon group having 10-26 carbon atoms, and R.sup.8 denotes a group --CH.sub.2 CH.sub.2 OH, --CH.sub.2 COOH or --COCH.sub.3.Type: GrantFiled: June 29, 1990Date of Patent: July 2, 1991Assignee: Kao CorporationInventors: Shinji Yano, Akira Kawamata, Yoshihiro Minematsu, Shuichi Akazaki, Mitsuko Zama, Genji Imokawa, Naotake Takaishi, Tsuyoshi Ohtomo, Takashi Komori
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Patent number: 5019604Abstract: A protective gel composition is disclosed for coating skin surfaces, particularly the hands of the surgical attendants prior to covering the hands with standard surgical gloves. In one example, the composition comprises controlled proportions in mixture by weight of lanolin, a liquid silicone, polypropylene glycol mono-oleate, polytetrafluoroethylene powder in microspherical form and zinc oxide powder. Anti-microbial and anti-viral agents may be further added to fortify the coating of the composition, with a preferred such agent being nonoxynol-9. The sterilized composition is applied to the hands after scrubbing and just prior to insertion into the gloves. The coating is water-repellent to prevent skin contact with body fluids, such as blood and blood products, that may penetrate the gloves and otherwise expose the skin to harmful microbial and viral infections. When the gloves are removed following the surgical procedure, the coating is easily removed with an alcohol and liquid detergent wash.Type: GrantFiled: April 26, 1989Date of Patent: May 28, 1991Inventor: Gerald M. Lemole
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Patent number: 5013726Abstract: An external analgesic lotion containing active ingredients of methyl salicylate and camphor and menthol to relieve pain in muscles, joints, or viscera distal at the site of application by stimulating cutaneous sensory receptors and a method of making such lotion and being made from camphor and menthol crystals.Type: GrantFiled: September 12, 1989Date of Patent: May 7, 1991Inventors: Jeffery W. Ivy, Curtis E. Payne
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Patent number: 5006331Abstract: Solubilized melanin based compositions supply melanin to skin, scalp and/or hair. The compositions consist of melanin, as an active ingredient, and a substance to solubilize the melanin blended together in a vehicle suitable for topical application. A melanin-based composition applied to the skin provides photoprotection of the human epidermis from exposure to ultraviolet rays. A melanin-based composition applied to wounds in the skin accelerates healing of the wounds. A melanin-based composition applied to the hair and scalp strengthens the hair.Type: GrantFiled: October 26, 1988Date of Patent: April 9, 1991Inventor: Frances C. Gaskin
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Patent number: 5002760Abstract: A skin care composition to prevent premature photoaging of the skin of the user includes in addition to basic ingredients, in combination, retinol, a UV absorber and a moisturizer.Type: GrantFiled: October 2, 1989Date of Patent: March 26, 1991Inventor: Phillip K. Katzev
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Patent number: 5000937Abstract: Transparent cosmetic composition that reflects infrared radiation and its use for protecting the human epidermis against infrared radiation.The invention relates to a transparent cosmetic composition comprising, by way of an agent that reflects infrared radiation for protecting the human epidermis, a substance which is dispersible in the cosmetic medium used, possessing a reflectance (R) of infrared radiation equal to at least 45%, and of which a 2% strength dispersion in vaseline possesses an optical transmission in the visible of at least 85%, chosen from a diatom of particle size less than 100 microns, hollow glass microspheres of size less than 100 microns, a bismuth oxychloride of particle size less than 75 microns and zirconium powder covered ceramic microparticles of particle size less than 8 microns.This cosmetic composition can also contain 0.5 to 20% by weight of UV-A, UV-B or broad-band screening agents.Type: GrantFiled: October 27, 1988Date of Patent: March 19, 1991Assignee: L'OrealInventors: Jean F. Grollier, Georges Rosenbaum, Jean Cotteret
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Patent number: 5000946Abstract: The invention relates to sunscreen compositions comprising an effective component at least one compound of formula I ##STR1## wherein R.sup.1 is selected from alkyl, alkenyl, alkynyl substituted alkyl, substituted alkenyl, phenyl, substituted phenyl, substituted benzyl, cycloalkyl, cycloalkenyl, substituted cycloalkyl, substituted cycloalkenyl and polymeric groups;R.sup.2 is selected from hydrogen, alkyl and alkoxy; and wherein R.sup.1 and R.sup.2 may form a carbocyclic ring which may be substituted;R.sup.3 is selected from alkyl, sustituted alkyl, alkenyl, substituted alkenyl, alkynyl, phenyl, benzoyl, substituted phenyl, substituted benzyl, substituted benzoyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, alkanyoyl, substituted alkanoyl, polymeric groups, the group OROROR.sup.9 wherein R is a bivalent hydrocarbon radical and R.sup.9 is alkyl, alkenyl, phenyl benzyl, substituted phenyl, substituted benzyl;R.sup.4 is alkyl or alkoxy; n is an integer from 0 to 4; andR.sup.Type: GrantFiled: May 26, 1988Date of Patent: March 19, 1991Inventors: Graham Bird, Neil Fitzmaurice, Walter C. Dunlap, Bruce E. Chalker, Wickramasinghe M. Bandaranayake
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Patent number: 4997666Abstract: A food composition containing a fat and an anti-oxidant is disclosed. The anti-oxidant is prepared by the extraction of natural anti-oxidants from plant substances.Type: GrantFiled: January 19, 1989Date of Patent: March 5, 1991Assignee: Bar-Ilan UniversityInventors: Michael Albeck, Shlomo Grossman
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Patent number: 4996239Abstract: A skin protective composition for exhibiting enhanced water repellency and conditioning effects containing aliphatic waxes and hydrophobic silicones in a nonallergenic, non-toxic, cosmetically acceptable carrier. The composition is useful to protect mammals from solar radiation and in the treatment of diaper rash.Type: GrantFiled: September 16, 1988Date of Patent: February 26, 1991Assignee: Neutrogena CorporationInventor: Peter Matravers
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Patent number: 4996238Abstract: A skin protective composition for exhibiting enhanced water repellency and conditioning effects containing aliphatic waxes and hydrophobic silicones in a nonallergenic, non-toxic, cosmetically acceptable carrier. The composition is useful to protect mammals from solar radiation and in the treatment of diaper rash.Type: GrantFiled: June 25, 1990Date of Patent: February 26, 1991Assignee: Neutrogena CorporationInventor: Peter Matravers
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Patent number: 4994263Abstract: A composition for treatment and treatment of certain skin diseases is disclosed. The treatment combines furocoumarins, UV-A radiation, and a benzylidene-camphor derivative. The composition and treatment produces the desirable results of the furocoumarin/UV-A radiation treatment without the undesirable phototoxic side effects.Type: GrantFiled: April 30, 1990Date of Patent: February 19, 1991Assignee: L'OrealInventors: Gerard Lang, Andre Deflandre, Irena Beck
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Patent number: 4988501Abstract: Sunscreen compositions comprising at least one bis-1,3-diketone derivatives of benzene and a cosmetically acceptable carrier are described. Also disclosed is a method of protecting human skin from the harmful effects of ultraviolet radiation employing such sunscreen composition.Type: GrantFiled: March 19, 1990Date of Patent: January 29, 1991Assignee: ICI Americas Inc.Inventor: Donald J. Gosciniak
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Patent number: 4985547Abstract: An external skin care preparation comprising a compound represented by the following general formula (I) or (II), or a salt thereof: ##STR1## wherein R.sup.1 means an aliphatic hydrocarbon group having 9-25 carbon atoms, A and B denote specific groups respectively, R.sup.6 and R.sup.7 are individually an aliphatic hydrocarbon group having 10-26 carbon atoms, and R.sup.8 denotes a group --CH.sub.2 CH.sub.2 OH, --CH.sub.2 COOH or --COCH.sub.3.Type: GrantFiled: March 3, 1988Date of Patent: January 15, 1991Assignee: Kao CorporationInventors: Shinji Yano, Akira Kawamata, Yoshihiro Minematsu, Shuichi Akazaki, Mitsuko Zama, Genji Imokawa, Naotake Takaishi, Tsuyoshi Ohtomo, Takashi Komori
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Patent number: 4985237Abstract: Disclosed herein are benzylidene compounds represented by the formula (I): ##STR1## wherein A represents ##STR2## (wherein B represents hydrogen atom or an acetyl group, W represents hydrogen atom or --CH.sub.2 --CH.sub.2 --CO--O--R, X.sup.1, X.sup.2 and X.sup.3 represent independently hydrogen atom, a hydroxyl group or a methoxyl group (two or three of them may be the same or all of them may be different), Y represents oxygen atom or imino group (--NH--), Z represents a methyl group or a phenyl group, and R represents a straight chain alkyl group having 1 to 18 carbon atoms, or branched or cyclic alkyl group having 3 to 18 carbon atoms, provided that when A is ##STR3## R is not an alkyl group having 1 to 2 carbon atoms, and when A is ##STR4## and X.sup.1, X.sup.2 and X.sup.3 are hydrogen atom, R is not an alkyl group having 1 to 2 carbon atoms), a cosmetic composition containing the same and an ultraviolet absorber comprising the same.Type: GrantFiled: October 18, 1988Date of Patent: January 15, 1991Assignee: Ajinomoto Co., Inc.Inventors: Kazuhiro Matsuno, Toru Kobayashi, Takeshi Miyoshi, Hideaki Kawashima
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Patent number: 4983385Abstract: An ointment base which comprises:(a) a hydrogel formed by a water-soluble polymer and a material selected from the group consisting of water, a polyhydric alcohol and a mixture thereof;(b) a methacrylate copolymer selected from a group consisting of dimethylaminoethyl methacrylate/methyl methacrylate copolymer, ethyl methacrylate/chlorotrimethylammonium ethyl methacrylate copolymer or a mixture thereof; and(c) a solubilizer which dissolves the methacrylate copolymer but is incompatible with water and the polyhydric alcohol,a weight ratio of the methacrylate copolymer to the solubilizer being 1:2-1:25.Type: GrantFiled: September 29, 1988Date of Patent: January 8, 1991Assignees: Sunstar Kabushiki Kaisha, Lederle (Japan), Ltd.Inventors: Kenji Hasegawa, Nakashima Nakashima, Toru Eguchi, Ota Masako
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Patent number: 4981693Abstract: A pharmaceutical composition for treating periodontal diseases which comprises one or more of therapeutically active ingredients admixed with a polymer capable of dissolving in an aqueous medium of pH 4.0 or higher.Type: GrantFiled: September 29, 1989Date of Patent: January 1, 1991Assignee: Rohto Pharmaceutical Co., Ltd.Inventors: Kiyotsugu Higashi, Shigeru Kametaka, Katsuhiko Morisaki, Shin'ichi Hayashi
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Patent number: 4981875Abstract: Etofenamate is used for the preparation of compositions useful in the treatment of bacterial, viral or fungicidal inflammations in the region of the oral cavity.Type: GrantFiled: July 22, 1988Date of Patent: January 1, 1991Assignee: Bayer AktiengesellschaftInventors: Bernd Leusner, Rudiger Heiss, Bernd Pelster, Wolfgang Fischer, Ulrich Ohm
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Patent number: 4971800Abstract: Method and compositions for enhancing the cutaneous penetration of topically or transdermally delivered pharmacologically active agents. The compositions include various urethane compounds as permeation enhancers, the urethane compounds formed from reaction of a monomeric organic diisocyanate with a hydroxy- or hydroxy/alkoxy-terminated linear alkylene or polyalkylene glycol or polyether.Type: GrantFiled: September 18, 1989Date of Patent: November 20, 1990Assignee: The Regents of the University of CaliforniaInventors: Samuel Chess, Jerry L. McCullough, Gerald D. Weinstein
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Patent number: 4965353Abstract: The invention concerns the esters of hyaluronic acid in which all or only a portion of the carboxylic groups of the acid are esterified, and the salts of the partial esters with metals or with pharmacologically acceptable organic bases.The compounds possess interesting and precious bioplastic and pharmaceutical properties and may be used in innumerable fields, including cosmetics, surgery and medicine. The invention also includes pharmaceutical preparations containing, as an active ingredient, one or more hyaluronic acid esters, or a salt thereof as described above, as well as medicaments containing:(1) a pharmacologically active substance or an association of pharmacologically active substances and(2) a carrying vehicle containing a total or partial ester of hyaluronic acid.The invention includes also various uses of the hyaluronic esters or of the above mentioned medicaments, such as in medicine, surgery or cosmetics.Type: GrantFiled: April 19, 1989Date of Patent: October 23, 1990Assignee: Fidia S.p.A.Inventors: Francesco della Valle, Aurelio Romeo
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Patent number: 4954345Abstract: The present invention is directed to a pharmaceutical preparation for external or transdermal application which comprises a dispersion of liposomes, wherein said liposomes incorporate or enclose an active ingredient.Type: GrantFiled: August 15, 1988Date of Patent: September 4, 1990Assignee: Rohm Pharma GmbHInventor: Joseph Muller
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Patent number: 4952560Abstract: An ointment base for external use is provided which contains a water-soluble protein and monohydric alcohol or/and oleginous substance and additionally contains a wetting agent. The present ointment base offers a markedly improved percutaneous absorption of drugs, as compared with the conventional ointment bases.Type: GrantFiled: April 11, 1988Date of Patent: August 28, 1990Assignee: Takeda Chemical Industries, Ltd.Inventors: Kazuo Kigasawa, Hideaki Ohtani, Makoto Tanaka, Shigeru Hayashida
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Patent number: 4950688Abstract: A composition suitable for topical application to human skin comprises, in addition to a suitable vehicle and a perfume, an active ingredient which can control skin barrier functions. The active ingredient is (a) a long chain .omega.-hydroxy fatty acid or a carboxy-substituted derivative, (b) an hydroxy- or epoxy-derivative of an essential fatty acid or an ester formed between (a) and (b). Certain novel compounds of structures (a), (b) and (a)(b) esters are also claimed.Type: GrantFiled: June 16, 1983Date of Patent: August 21, 1990Assignee: Conopco, Inc.Inventors: Paul A. Bowser, Albert Froling, Lammert Heslinga, Udo M. T. Houtsmuller, Diederik H. Nugteren, Hendrik J. J. Pabon, Colin Prottey
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Patent number: 4948580Abstract: A bioadhesive composition is provided which may be employed as an oral drug delivery system and includes a freeze-dried polymer mixture formed of the copolymer poly(methyl vinyl ether/maleic anhydride) and gelatin, which is dispersed in an ointment base such as mineral oil containing dispersed polyethylene. Such bioadhesive compositions may be used to deliver oral mucosa active ingredients such as steroids, anti-fungal agents, anti-bacterial agents and the like.Type: GrantFiled: December 8, 1988Date of Patent: August 14, 1990Assignee: E. R. Squibb & Sons, Inc.Inventor: Ivan Browning
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Patent number: 4946868Abstract: The invention concerns compositions with antimicrobial activity.These compositions contain a benzoic acid derivative with the formula: ##STR1## in which: A represents a straight or branched alkyl chain with 3 to 4 carbon atoms,X represents the oxygen atom or a direct bond,R represents hydrogen or an alkyl group with 2 to 6 carbon atoms, possibly substituted by an alcohol function and a salt of such a derivative.Applications: drugs, disinfectants and preservative agents.Type: GrantFiled: August 13, 1984Date of Patent: August 7, 1990Assignee: SanofiInventors: Henri Demarne, Robert Filhol, Madeleine Mosse
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Patent number: 4946832Abstract: Cosmetic Base composition exhibiting therapeutic properties comprising an acyl fatty acid alpha-hydroxy carboxylic acid ester or alkali metal salt thereof, a sucrose fatty acid ester, and a solvent.Type: GrantFiled: July 21, 1988Date of Patent: August 7, 1990Assignee: R.I.T.A. CorporationInventors: Stephen T. Goode, Robert R. Linton, Fred Baiocchi
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Patent number: 4946671Abstract: Disclosed are pharmaceutical compositions comprising sorbohydroxamic acid, or pharmaceutically-acceptable salts thereof, and an anti-inflammatory agent, which are useful for topical application to prevent damage to skin caused by acute or chronic UV exposure. Combinations of sorbohydroxamic acid and an anti-inflammatory agent together with tocopherol sorbate and/or sunscreens are also disclosed.Also disclosed is a method for using these compositions topically to prevent damage to skin caused by acute or chronic UV exposure.Type: GrantFiled: May 2, 1989Date of Patent: August 7, 1990Assignee: The Procter & Gamble CompanyInventors: Donald L. Bissett, Ranjit Chatterjee
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Patent number: 4946870Abstract: Delivery systems containing at least one aminopolysaccharide derivative are provided for the delivery of pharmaceutical or therapeutic actives to a desired topical or mucous membrane site in a subject, and wherein upon delivery, the systems provides a biocompatible, substantive, gas permeable, film from which actives are available at the designated site.Type: GrantFiled: November 8, 1988Date of Patent: August 7, 1990Assignee: Union Carbide Chemicals and Plastics Company Inc.Inventors: Emmett M. Partain, III., George L. Brode, II.
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Patent number: 4931210Abstract: The present invention relates to a process for producing a W/O/W type multiple emulsion using a polyglycerol polyricinolate (i.e. a polyglycerol ester of a polycondensed fatty acid of castor oil).The use of the polyglycerol polyricinolate is effective in increasing the rate of formation of the W/O/W type multiple emulsion remarkably and giving a W/O/W type multiple emulsion which is stable over a long period of time. The W/O/W type multiple emulsion has also an excellent heat stability and is useful for the production of medicines and cosmetics.Type: GrantFiled: September 19, 1988Date of Patent: June 5, 1990Assignee: Menji Milk Products Company LimitedInventors: Yasuyuki Takahashi, Toshiro Yoshida, Takeshi Takahashi
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Patent number: 4927631Abstract: A decongestant preparation is disclosed which comprises a set of active components and a petrolatum base wherein the active components consist essentially of menthol, camphor, eucalyptus oil, and spirits of turpentine, wherein the total concentration of the active components is no greater than about 1.0% by weight of the decongestant preparation, and wherein the set of active components consists essentially of in percent by weight from about 15 to about 25 menthol, from about 30 to about 40 camphor, from about 5 to about 10 eucalyptus oil, and from about 30 to about 40 spirits of turpentine, the decongestant being suitable for direct application to the nasal cavity.Type: GrantFiled: February 16, 1989Date of Patent: May 22, 1990Inventor: Harry L. Bates
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Patent number: 4925736Abstract: A topical hematoporphyrin composition, the method for its production, and a method for its use in the treatment of human papillomavirus disease are described. The hematoporphyrin composition is capable of being absorbed by diseased tissue, thus enabling destruction of the tissue upon exposure to 625 to 635nm light.Type: GrantFiled: July 6, 1988Date of Patent: May 15, 1990Assignee: Long Island Jewish Medical CenterInventor: Mark J. Shikowitz
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Patent number: 4923693Abstract: An inventive method for preventing ultraviolet radiation exposure to the outer tissues of mammalian eyes is disclosed. In particular, the composition containing about 0.3%-0.4% hydroxypropylmethylcellulose in the form of either an eyedrop solution or an ointment is applied to the eyes prior to exposure to UV radiation.Type: GrantFiled: January 21, 1988Date of Patent: May 8, 1990Assignee: Sundrops Enterprises, Inc.Inventor: Peter Michalos
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Patent number: 4919934Abstract: Disclosed are wax based cosmetic stick compositions comprising: from about 10% to about 50% of a wax type solidifying agent; and from about 5% to about 90% of a polyalphaolefin. These compositions preferably comprise from about 1.0% to about 40% of an active component, such as a sunscreen agent, analgesic, moisturizing and antiperspirant or a deodorant active.Type: GrantFiled: March 2, 1989Date of Patent: April 24, 1990Assignee: Richardson-Vicks Inc.Inventors: George E. Deckner, Rupali A. Kulkarni
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Patent number: 4906457Abstract: Compositions and methods for reducing the risk of skin cancer. The novel compositions include at least one effective protease inhibitor. Preferred protease inhibitors include serine protease inhibitors and metallo- protease inhibitors. The protease inhibitors are preferably included in concentrations ranging from approximately 10 picograms to 10 milligrams per milliliter of the skin-applicable topical mixtures. The topical mixtures preferably include a suitable topical vehicle such as a cream, lotion, or ointment. One class of anti-carcinogenic skin treatment compositions of this invention preferably includes the desired protease inhibitors in combination with a suitable sunscreen agent or agents, such as para-amino benzoic acid, to provide particularly advantageous compositions for reducing the risk of sunlight-induced skin cancer.Type: GrantFiled: September 6, 1988Date of Patent: March 6, 1990Assignee: Washington State University Research Foundation, Inc.Inventor: Clarence A. Ryan
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Patent number: 4906670Abstract: A pharmaceutical composition useful for treatment of periodontal diseases which comprises one or more active ingredients effective for the treatment of periodontal diseases, characterized in that said active ingredient or ingredients are dispersed in collagen.Type: GrantFiled: March 1, 1989Date of Patent: March 6, 1990Assignee: Rohto Pharmaceutical Co., Ltd.Inventors: Kiyotsugu Higashi, Shigeru Kametaka, Reiko Izumi, Katsuhiko Morisaki, Shin'ichi Hayashi
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Patent number: 4897260Abstract: Glucocorticoid carboxylic acid esters and topical compositions thereof are utilized in methods for modulating cutaneous delayed hypersensitivity. Formulations of the glucocorticoid carboxylic acid esters are disclosed including incorporation into percutaneous drug delivery devices.Type: GrantFiled: February 29, 1988Date of Patent: January 30, 1990Assignee: The Rockefeller UniversityInventors: Peter M. Ross, H. Leon Bradlow
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Patent number: 4894222Abstract: A skin protective composition for topical application to mammalian skin for protection from water washing containing C.sub.18 -C.sub.36 aliphatic wax and anhydrous starch as its principal active waterproofing agents disposed in a water-free carrier.Type: GrantFiled: April 4, 1988Date of Patent: January 16, 1990Assignee: Neutrogena CorporationInventor: Peter Matravers
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Patent number: 4892727Abstract: A cosmetic or dermopharmaceutical composition comprises in an appropriate support or vehicle, a powder of sweet lupine seeds essentially free of alkaloids.Type: GrantFiled: July 24, 1986Date of Patent: January 9, 1990Assignee: Societe Anonyme dite: L'OREALInventor: Jean-Francois Grollier
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Patent number: 4892890Abstract: The present disclosure relates to an external analgesic solid stick composition for the topical administration of active analgesic agents. The compositions are dimensionally stable solid compositions comprising an external analgesic agent incorporated into a non-reactive hydrophobic wax matrix.Type: GrantFiled: May 5, 1986Date of Patent: January 9, 1990Assignee: G. D. Searle and CompanyInventor: Nalinkant C. Damani