Contact Lens Making Composition Patents (Class 523/106)
  • Patent number: 10513628
    Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: December 24, 2019
    Assignee: Novartis AG
    Inventors: Yongxing Qiu, John Dallas Pruitt, Sibichen J. Thekveli, Robert Carey Tucker, Jared Nelson
  • Patent number: 10261344
    Abstract: This invention discloses methods and apparatus for providing an ophthalmic lens of variable optical power. The variable optic insert may have surfaces within that have differing radii of curvature. The variable optic insert may also comprise polarizing elements. In some examples, an intermediate optic piece may be formed to comprise a UV absorbing dye, allowing differential processing of regions on either side of the intermediate optic piece. In some embodiments, an ophthalmic lens is cast-molded from a silicone hydrogel. The various ophthalmic lens entities may include electroactive liquid crystal layers to electrically control refractive characteristics.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: April 16, 2019
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Randall B. Pugh, Frederick A. Flitsch
  • Patent number: 10156660
    Abstract: An method for manufacturing an ophthalmic lens comprises following steps of providing a mixture comprising a gel precursor and a plurality of melanin or melanin analog pigments, each of the plurality of melanin or melanin analog pigment comprising at least one group having a chemical structure of or the gel precursor comprising an organic additive selected from a group consisting of dopamine methacrylamide having a chemical structure of 2-aminoethyl methacrylate having a chemical structure of N-(3-aminopropyl)methacrylamide having a chemical structure of N-(2-aminoethyl)methacrylamide having a chemical structure of and any combination thereof; feeding the mixture into a mold, and exposing the mixture to ultraviolet radiation or heating the mixture to form a gel substrate, the melanin or melanin analog pigments dispersed in the gel substrate and anchored to the gel substrate, thereby forming the ophthalmic lens. The disclosure also provides an ophthalmic lens.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: December 18, 2018
    Assignee: MiiCs & Partners (Shenzhen) Co., Ltd.
    Inventor: Hsiu-Wen Chien
  • Patent number: 10064977
    Abstract: Intraocular lens materials are disclosed. They are soft and very deformable and have a high refractive index, and a high glistening resistance in fully hydrated state. They are particularly suitable for making wet-packed intraocular lenses (IOLs) which can be delivered through sub 2.0 mm incisions.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: September 4, 2018
    Assignee: Novartis AG
    Inventors: Xuwei Jiang, Douglas Schlueter, Walter Laredo
  • Patent number: 9971245
    Abstract: The present invention provides a silicon-containing polymer which contains a repeating unit shown by the general formula (1-3) and one or more repeating units selected from repeating units shown by the general formulae (1-1) and (1-2) as a partial structure. There can be provided a composition for forming a silicon-containing resist under layer film, and a silicon-containing polymer and a silicon-containing compound to give the composition that is capable of forming a resist under layer film improved in adhesiveness in any resist pattern, regardless of negative development or positive development.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: May 15, 2018
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Tsutomu Ogihara, Takeru Watanabe, Kazunori Maeda
  • Patent number: 9958577
    Abstract: This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: May 1, 2018
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Kevin P. McCabe, Frank F. Molock, Jr., Gregory A. Hill, Azaam Alli, Robert B. Steffen, Douglas G. Vanderlaan, James D. Ford
  • Patent number: 9902793
    Abstract: A method for making an ophthalmic lens includes following steps of providing a mixture comprising a hydrophilic monomer, a clay, a cross-linking agent, an initiator, and a solvent; and feeding the mixture into a mold and exposing the mixture to ultraviolet radiation or heating the mixture, to cause the hydrophilic monomer, the cross-linking agent, and the initiator in the mixture to undergo a polymerization reaction to form a cross-linking network, and the clay in the mixture to be dispersed in the cross-linking network, thereby forming the ophthalmic lens. The disclosure also provides an ophthalmic lens made by above method, and an ophthalmic lens material making for the ophthalmic lens.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: February 27, 2018
    Assignee: HON HAI PRECISION INDUSTRY CO., LTD.
    Inventor: Hsiu-Wen Chien
  • Patent number: 9670300
    Abstract: A thermoplastic copolymer that includes a first divalent unit having a pendent ultraviolet absorbing group and a second divalent unit that is fluorinated. A fluoropolymer composition including the thermoplastic copolymer is also disclosed.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: June 6, 2017
    Assignee: 3M Innovative Properties Company
    Inventors: David B. Olson, Patricia M. Savu, Timothy J. Hebrink
  • Patent number: 9632212
    Abstract: To provide a medical device which is excellent in wettability and lubricity and is also scarcely broken since it is soft, by a medical device in which a layer made of an acidic polymer and a basic polymer is formed on at least a part of a surface of a low water content soft base material, the low water content soft base material containing, as a main component, a copolymer containing a monofunctional monomer component M having one polymerizable functional group and one silicone moiety per molecule.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: April 25, 2017
    Assignee: Toray Industries, Inc.
    Inventors: Kazuhiko Fujisawa, Rumiko Kitagawa, Masataka Nakamura
  • Patent number: 9612363
    Abstract: Disclosed in this specification is a method for forming a silicone hydrogel material that is useful for forming contact lens materials. The method includes using an effective amount of a borate additive to reduce the gel time of the silicone hydrogel reactive mixture and/or enhance the optical properties of the resulting cured material.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: April 4, 2017
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Douglas G. Vanderlaan, James D. Ford
  • Patent number: 9574038
    Abstract: HEMA-compatible siloxane monomers are described that can be used to manufacture contact lenses that combine the attributes of HEMA-based contact lenses with the high oxygen permeability of silicone hydrogel lenses. Optically clear silicone hydrogel contact lens can be manufactured that comprise a polymeric lens body that is the reaction product of a polymerizable composition comprising: a) at least 25 wt. % of at least one hydroxyalkyl methacrylate; and b) at least 20 wt. % of at least one HEMA-compatible polysiloxane.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: February 21, 2017
    Assignee: CooperVision International Holding Company, LP
    Inventors: Hiroyuki Ueyama, Charlie Chen, Yuan Xu, Yuwen Liu, Ying Zheng, Paul Richardson, Hong Xue
  • Patent number: 9562161
    Abstract: The present invention relates to a process comprising the steps of reacting a reactive mixture comprising at least one silicone-containing component, at least one hydrophilic component, and at least one diluent to form an ophthalmic device having an advancing contact angle of less than about 80°; and contacting the ophthalmic device with an aqueous extraction solution at an elevated extraction temperature, wherein said at least one diluent has a boiling point at least about 10° higher than said extraction temperature.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: February 7, 2017
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Azaam Alli, Douglas G. Vanderlaan, James D. Ford, Scott L. Joslin
  • Patent number: 9521842
    Abstract: The use of poly(oxybutylene)-poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses, but do not induce foaming when used in conjunction with a peroxide-based contact lens disinfection regimen. Such compounds may also be useful for cleaning purposes. The use of the compounds as surfactants in peroxide-based compositions for disinfecting contact lenses therefore represents a preferred embodiment of the present invention.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: December 20, 2016
    Assignee: ALCON RESEARCH, LTD.
    Inventors: James W. Davis, Howard Allen Ketelson
  • Patent number: 9507172
    Abstract: The invention provides silicone hydrogel contact lenses that exhibit reduced back surface debris and reduced incidence of superior epithelial accurate lesions.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: November 29, 2016
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Robert B. Steffen, David C. Turner, Douglas G. Vanderlaan
  • Patent number: 9289954
    Abstract: Example eye-mountable devices and methods for fabricating eye-mountable devices are described. A method may include applying a first amount of polymerizable material to a ring-shaped structure, where the ring-shaped structure comprises at least one sensor configured to detect an analyte. The method also may include positioning the ring-shaped structure with the first amount of polymerizable material applied thereto in a mold, where the mold is configured to form an eye-mountable device. Further, the method may include applying pressure on the ring-shaped structure in the mold while curing the first amount of polymerizable material. Still further, the method may include adding a second amount of polymerizable material to the mold with the ring-shaped structure therein, and curing the second amount of polymerizable material to form an over-molded polymer layer such that the ring-shaped structure is at least partially enclosed in the eye-mountable device.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: March 22, 2016
    Assignee: Verily Life Sciences LLC
    Inventors: Jeffrey George Linhardt, Harvey Ho
  • Patent number: 9248928
    Abstract: Contact lenses comprising an ionic component are packaged with a beneficial cationic agent in a temperature-sensitive packaging solution and/or a low ionic strength packaging solution.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: February 2, 2016
    Assignee: CooperVision International Holding Company, LP
    Inventors: Victoria Rogers, Andrew Luk, Arthur Back, Charlie Chen
  • Patent number: 9233495
    Abstract: The present invention relates to a sheet for forming a hard coating and a method of formation. The present invention can provide a transfer material or a surface protection sheet having a high index of refraction and superior physical properties, such as hardness, friction resistance, abrasion resistance, chemical resistance, transparency, luster, and the like, for forming a hard coating on the surface of various molded products, including resin molded products or wood products, and a method for forming a hard coating from such transfer material or surface protection sheets.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: January 12, 2016
    Assignee: LG HAUSYS, LTD.
    Inventors: Yun-Bong Kim, Won-Kook Kim, Dong-Joo Gwon, Yang-Gu Kang, Jin-Woo Kim, Mu-Seon Ryu
  • Patent number: 9156934
    Abstract: The present invention relates to a process comprising the steps of reacting a reactive mixture comprising at least one silicone-containing component, at least one hydrophilic component, and at least one diluent to form an ophthalmic device having an advancing contact angle of less than about 80°; and contacting the ophthalmic device with an aqueous extraction solution at an elevated extraction temperature, wherein said at least one diluent has a boiling point at least about 10° higher than said extraction temperature.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: October 13, 2015
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Azaam Alli, Douglas G. Vanderlaan, James D. Ford, Scott L. Joslin
  • Patent number: 9052438
    Abstract: Various non-limiting embodiments of the present disclosure relate to ophthalmic devices comprising photochromic materials comprising a reactive substituent. For example, the present disclosure contemplates ophthalmic devices comprising photochromic materials, such as photochromic naphthopyrans and indeno-fused naphthopyrans having a reactive substituent comprising a reactive moiety linked to the photochromic naphthopyran by one or more linking groups. In certain non-limiting embodiments, the reactive moiety comprises a polymerizable moiety. In other non-limiting embodiments, the reactive moiety comprises a nucleophilic moiety. Other non-limiting embodiments of the present disclosure relate to methods of making the photochromic ophthalmic device, wherein the photochromic ophthalmic devices comprise the photochromic naphthopyrans described herein.
    Type: Grant
    Filed: April 8, 2005
    Date of Patent: June 9, 2015
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Wenjing Xiao, Barry Van Gemert, Shivkumar Mahadevan, Frank Molock
  • Patent number: 9039174
    Abstract: The present application relates to novel monomers comprising polycarbosiloxane monomers useful in certain specific embodiments in the manufacture of devices. More particularly, the present application relates to certain ethylenically unsaturated free radical polymerizable monomers comprising polycarbosiloxane monomers. Even more particularly, the present application pertains to monomers comprising polycarbosiloxane monomers which further comprise at least two ethylenically unsaturated free radical polymerizable groups.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 26, 2015
    Assignee: Bausch & Lomb Incorporated
    Inventors: Alok Kumar Awasthi, Jay F. Kunzler
  • Patent number: 9023915
    Abstract: Disclosed herein are surface treatments for soft silicone gel materials such as silicone intraocular lenses.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 5, 2015
    Assignee: Abbott Medical Optics Inc.
    Inventors: Can B. Hu, Derek D. Pham
  • Patent number: 9022562
    Abstract: Described herein are devices, compositions, and methods for improving color discernment.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: May 5, 2015
    Assignee: Nitto Denko Corporation
    Inventors: Brett T. Harding, Sheng Li, Amane Mochizuki, Eugene Dantsker
  • Patent number: 9012581
    Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials contain a copolymeric additive for glistening resistance.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: April 21, 2015
    Assignee: Novartis AG
    Inventor: Walter R. Laredo
  • Publication number: 20150099822
    Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
    Type: Application
    Filed: December 16, 2014
    Publication date: April 9, 2015
    Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
  • Publication number: 20150087743
    Abstract: Fluids incorporated into intraocular lenses and their methods of use. In some embodiments the fluids are silicone oils, and in some embodiments they are used in accommodating intraocular lenses.
    Type: Application
    Filed: November 26, 2014
    Publication date: March 26, 2015
    Inventors: David J. ANVAR, Andrew GOODWIN, David CHAZAN
  • Patent number: 8980956
    Abstract: A method for producing polymerizable solution which comprises dissolving an ethylenically unsaturated zwitterionic monomer in a co-monomer system comprising a functionalized ethylenically unsaturated monomer in which the zwitterionic monomer is soluble, a siloxane group-containing monomer or macromer, and a crosslinking agent is disclosed. The polymerizable solution is biocompatible and can be used to produce polymers and articles such as contact lenses.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: March 17, 2015
    Assignee: Vertellus Specialities Inc.
    Inventors: Michael Driver, Qingpu Hou, Jin Hai Wang
  • Patent number: 8980972
    Abstract: Polymerisable material which comprises a polymerisable group, a siloxane group-containing component and a zwitterionic group is described. The polymerisable material may be used to produce polymers and articles, in particular contact lenses.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: March 17, 2015
    Assignee: Vertellus Specialties Inc.
    Inventor: Michael Driver
  • Publication number: 20150061168
    Abstract: The present invention provides optic portions, intraocular lenses, and polymers for use in manufacturing optic portions and intraocular lenses. The optic portions include a polymer that comprises (a) one or more alkoxyalkyl methacrylate monomers and/or one or more alkoxyalkyl acrylate monomers that are incorporated in the polymer; (b) one or more hydroxyalkyl methacrylate monomers and/or one or more hydroxyalkyl acrylate monomers that are incorporated in the polymer; and (c) optionally, one or more crosslinking agents that are incorporated in the polymer.
    Type: Application
    Filed: September 15, 2014
    Publication date: March 5, 2015
    Applicant: Benz Research and Development Corporation
    Inventors: Patrick H. BENZ, Jose A. ORS
  • Publication number: 20150057389
    Abstract: A wettable hydrogel or a silicone hydrogel device includes a polymerized surfactant incorporated into the gel by addition to a gel, on average, of a single ethylenic functionality of the precursor polymerizable surfactant in the polymerization mixture. The attached polymerized surfactant provides improved lubricity to the hydrogel or silicone hydrogel device. Alternately, a wettable hydrogel or a silicone hydrogel device can be formed by soaking a preformed hydrogel or a silicone hydrogel device in a solution of the polymerizable surfactant and a radical initiator and promoting the polymerization of the polymerizable surfactant and available polymerizable groups on or in the device. The wettable hydrogel or a silicone hydrogel device can be a contact lens.
    Type: Application
    Filed: August 22, 2014
    Publication date: February 26, 2015
    Inventors: ANUJ CHAUHAN, LOKENDRAKUMAR CHAINROOM KUMAR BENGANI
  • Publication number: 20150038612
    Abstract: Novel methods and materials particularly useful for ophthalmic applications and to methods for making and using the same are disclosed herein. More particularly, relatively soft, optically transparent, foldable, high refractive index materials particularly suited for use in the production of intraocular lenses, contact lenses, and other ocular implants and to methods for manufacturing and implanting IOLs made therefrom are disclosed.
    Type: Application
    Filed: October 17, 2014
    Publication date: February 5, 2015
    Inventor: Khalid Mentak
  • Patent number: 8927618
    Abstract: The present invention provides a dye composition for an ophthalmic lens, which is a dye composition used for dyeing an ophthalmic lens with an ink-jet coating equipment, characterized by the composition including: (A) a dye having at least one group having a carbon-carbon double bond selected from an ?,?-unsaturated carbonyl group, a styryl group, a vinylbenzyl group and an allyl group per molecule; (B) a radical polymerization initiator; and (C) a solvent capable of dissolving at least a part of the component (A) and the component (B), and/or (D) a monomer having at least one radical polymerizable group per molecule.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: January 6, 2015
    Assignee: Menicon Co., Ltd.
    Inventors: Yuji Goto, Ichiro Ando, Ryo Matsushita
  • Patent number: 8921449
    Abstract: In one aspect, the invention relates to hydrolysis-resistant silicone compounds. In particular, disclosed are sterically hindered hydrolysis-resistant silicone compounds and improved purity hydrolysis-resistant silicone compounds. Also disclosed are processes for making hydrolysis-resistant silicone compounds; the products of the disclosed processes; compositions and polymers comprising the disclosed compounds and products of the disclosed processes; and ophthalmic lenses, for example contact lenses, intraocular lenses, artificial cornea, and spectacle lenses, comprising the disclosed compositions, disclosed polymers, disclosed compounds, and products of the disclosed processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: January 21, 2013
    Date of Patent: December 30, 2014
    Assignees: Johnson & Johnson Vision Care Inc., Toray Industries, Inc.
    Inventors: Kazuhiko Fujisawa, Masataka Nakamura, Mitsuru Yokota, Douglas G. Vanderlaan
  • Patent number: 8916622
    Abstract: A heat-curable composition comprises—from 25 to 65% by weight of a mixture of epoxy-functional monomers, said mixture consisting of at least one polyfunctional epoxy monomer selected from monomers comprising from 4 to 8 glycidyl groups and/or cycloaliphatic epoxy groups, and at least one bi- or tri-functional epoxy monomer selected from monomers comprising two or three glycidyl groups and/or cycloaliphatic epoxy groups, —from 25 to 70% by weight of at least one organic solvent selected from glycol monoethers, —from 2.5 to 5% by weight, relative to the total weight of epoxyfunctional monomers (a) and (b), of at least one blocked strong acid catalyst, said heat-curable composition not containing any non-epoxyfunctional monomers, in particular not containing any acrylic, methacrylic or silane monomers.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: December 23, 2014
    Assignee: Essilor Internatonal (Compagnie Générale d'Optique)
    Inventor: Robert Valeri
  • Patent number: 8901190
    Abstract: A method for modifying the refractive index of an optical, hydrogel polymeric material. The method comprises irradiating predetermined regions of an optical, polymeric material with a laser to form refractive structures. To facilitate the formation of the refractive structures the optical, hydrogel polymeric material comprises a photosensitizer. The presence of the photosensitizer permits one to set a scan rate to a value that is at least fifty times greater than a scan rate without the photosensitizer in the material, yet provides similar refractive structures in terms of the observed change in refractive index. Alternatively, the photosensitizer in the polymeric material permits one to set an average laser power to a value that is at least two times less than an average laser power without the photosensitizer in the material, yet provide similar refractive structures.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: December 2, 2014
    Assignees: University of Rochester, Rochester Institute of Technology
    Inventors: Thomas Smith, Wayne H. Knox, Li Ding, Dharmendra Jani, Jeffrey G. Linhardt
  • Publication number: 20140333893
    Abstract: Provided are a low hydrous soft ophthalmic lens that can remarkably reduce or avoid a phenomenon in which a lens sticks to a cornea when worn and can reduce a decrease in the performance of a coating layer when rubbing the low hydrous soft ophthalmic lens for cleaning and a method for manufacturing the same. The low hydrous soft ophthalmic lens has a layer formed of a hydrophilic polymer on at least part of the surface of a base material containing a polysiloxane compound, and at least part of the inside of the layer is cross-linked.
    Type: Application
    Filed: August 15, 2012
    Publication date: November 13, 2014
    Applicant: Toray Industries, Inc.
    Inventors: Rumiko Kitagawa, Masataka Nakamura, Satoru Ogasahara
  • Publication number: 20140336303
    Abstract: Described herein are devices, compositions, and methods for improving color discernment.
    Type: Application
    Filed: July 22, 2014
    Publication date: November 13, 2014
    Inventors: Brett T. Harding, Sheng Li, Amane Mochizuki
  • Patent number: 8883874
    Abstract: The present invention relates to compositions comprising a polymeric substrate comprising at least one volume excluding polymer. In one embodiment, the present invention provides polymeric articles that are capable of acting as osmotic drivers. The articles are capable of maintaining a desired water balance by moving water in or out of a substrate to maintain cation concentration equilibrium between the substrate and its environment.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: November 11, 2014
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Brian J. Tighe, Muriel Nasso, Beverley Benning, Frank F. Molock, Jr.
  • Patent number: 8877829
    Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymeric compositions comprise polymerized cationic hydrophilic siloxanyl monomers prepared by the process disclosed herein.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: November 4, 2014
    Assignee: Bausch & Lomb Incorporated
    Inventors: Derek A. Schorzman, Joseph C. Salamone, Daniel M. Ammon, Jr.
  • Patent number: 8871016
    Abstract: The present invention provides cellulose hydrogels having one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The present invention further provides a process for preparing a cellulose hydrogel comprising: (i) contacting cellulose with a solvent to activate the cellulose; (ii) optionally removing the solvent from the activated cellulose; (iii) substantially dissolving the activated cellulose to form a solution; (iv) allowing the solution to gel; and optionally (v) drying the gel and rehydrating the gel. The cellulose hydrogel can have many uses, including uses as contact lenses.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: October 28, 2014
    Assignee: The Johns Hopkins University
    Inventors: Morgana M. Trexler, Jenna L. Graham, Jennifer L. Breidenich, Jeffrey P. Maranchi, Julia B. Patrone, Marcia W. Patchan, Jennifer H. Elisseeff, Xiomara Calderon-Colon
  • Patent number: 8865929
    Abstract: A method for preparing a polymerizable monomer-dye compound is provided in which a monomer, a reactive dye, and base are combined under substantially anhydrous reaction conditions to form the polymerizable monomer-dye compound, wherein the monomer comprises a pendant reactive group that covalently links to the reactive dye to form the monomer-dye compound.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: October 21, 2014
    Assignee: CooperVision International Holding Company, LP
    Inventors: Yuan Xu, Charlie Chen, Charles A. Francis, Shane Mao, Hong Xue, Xining Zhang
  • Publication number: 20140309328
    Abstract: The present invention relates to polyurethane polymer compositions prepared by reacting a mixture comprising: a) at least one poly(ethylene glycol), b) at least one polyoxyalkylene diol (typically PPG or a copolymer of ethylene oxide and propylene oxide), c) at least one di- or poly-isocyanate, d) at least one polyol or macropolyol having a functionality greater than 2, or a mixture of such polyols or macropolyols having a functionality greater than 2, e) optionally an additional compound comprising at least one hydroxyl group and at least one primary or secondary amine group. The present invention also relates to an article comprising such a polymer, in particular a medical device such as a contact lens. A process for preparing a polyurethane hydrogel is also provided.
    Type: Application
    Filed: April 19, 2012
    Publication date: October 16, 2014
    Applicant: Ocutec Limited
    Inventors: Rashid Abdul, Neil Bonnette Graham, Roderick Bowers, Wade Tipton, John Fraser
  • Patent number: 8835526
    Abstract: The present invention provides optic portions, intraocular lenses, and polymers for use in manufacturing optic portions and intraocular lenses. The optic portions include a polymer that comprises (a) one or more alkoxyalkyl methacrylate monomers and/or one or more alkoxyalkyl acrylate monomers that are incorporated in the polymer; (b) one or more hydroxyalkyl methacrylate monomers and/or one or more hydroxyalkyl acrylate monomers that are incorporated in the polymer; and (c) optionally, one or more crosslinking agents that are incorporated in the polymer.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: September 16, 2014
    Assignee: Benz Research and Development Corporation
    Inventors: Patrick H. Benz, Jose A. Ors
  • Patent number: 8820925
    Abstract: Contact lenses, such as hydrogel contact lenses, are described. The present contact lenses include a lens body that is the reaction product of a polymerizable composition. The polymerizable composition includes one or more monomers and a crosslinker that crosslinks the one or more monomers during polymerization. The polymerization of the one or more monomers occurs in the presence of a hydrophilic polymer that is present in the polymerizable composition, which comprises a polymer of 2-methacryloyloxyethyl phosphorylcholine. The present lenses are capable of releasing the hydrophilic polymer from the contact lens for prolonged periods of time and also have a reduced surface friction compared to similar lenses without the hydrophilic polymer. The present invention also relates to packaging systems for use with such lenses and methods of producing such lenses.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: September 2, 2014
    Assignee: CooperVision International Holding Company, LP
    Inventor: Yuwen Liu
  • Patent number: 8808866
    Abstract: An elastomeric article, such as a glove or a condom, is coated with a compound containing silicone, collagen and allantoin.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: August 19, 2014
    Assignees: Precision Components, Inc., Xela Corporation
    Inventors: Anil Segat, Andreas Brown
  • Patent number: 8807745
    Abstract: A substantially fully copolymerized UV blocking hydrogel lens demonstrating sufficient blocking of UV light to meet at least FDA Class II specifications for UV blocking formed from a reaction mixture comprising at least NVP and one other comonomer and a free-radical polymerizable, substituted or unsubstituted, Bis O-hydroxy benzophenone is provided herein.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: August 19, 2014
    Assignee: Bausch & Lomb Incorporated
    Inventors: Ivan Nunez, Jennifer Hunt
  • Patent number: 8759414
    Abstract: Described is the use of polymers with a high refractive index for ophthalmic products and a process for the production thereof.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: June 24, 2014
    Assignee: Coronis GmbH
    Inventors: Wolfgang Müller-Lierheim, Joachim Storsberg, André Laschewsky, Eckhard Görnitz, Elsbeth Winter
  • Patent number: 8741981
    Abstract: The invention provides silicone hydrogel contact lenses that exhibit reduced back surface debris and reduced incidence of superior epithelial arcurate lesions.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: June 3, 2014
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Robert B. Steffen, David C. Turner, Douglas G. Vanderlaan
  • Patent number: 8729149
    Abstract: Embodiments of silicone hydrogels, ophthalmic lenses made therefrom, and methods of making the same are described. Fully hydrated silicone hydrogels have relatively high water content and oxygen permeability, along with relatively low modulus of elasticity. Embodiments of the silicone hydrogels in substantially dehydrated condition are adapted to lathe cutting at or above room temperature. Variations of the silicone hydrogels include silicon-containing monomers in an amount of 7.5% or greater by weight, a hydrophilic substituted N-vinyl acetamide monomer, and a hydrophilic non-acetamide monomer in an amount resulting in a hydrophilic substituted N-vinyl acetamide monomer to hydrophilic non-acetamide monomer weight to weight ratio of greater than 2.1 to 1.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: May 20, 2014
    Inventors: Timothy Higgs, Tristan Tapper, Richard Young
  • Patent number: 8703875
    Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least two different hydrophilic monomers selected from the group consisting of N,N-dimethyl acrylamide (DMA), 2-hydroxyethyl acrylate (HEA), glycidyl methacrylate (GMA), N-vinylpyrrolidone (NVP), acrylic acid (AA) and a C1-C4-alkoxy polyethylene glycol(meth)acrylate having a weight average molecular weight of from 200 to 1500, and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: April 22, 2014
    Assignee: Novartis AG
    Inventors: Frank Chang, Norberto Arturo Medina
  • Patent number: 8697770
    Abstract: A method for making a hydrogel, photochromic contact lens including supplying a first lens composition comprising a contact lens monomer and a photochromic material to a front contact lens mold and supplying a second lens composition to said contact lens mold wherein the viscosity of said first composition is at least about 1000 cp greater than the viscosity of said second contact lens composition, and the makeup of said second composition matches the of said first composition to reduce strain between said compositions of the resulting lens.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: April 15, 2014
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Donnie J. Duis, Yongcheng Li, Leilani K. Sonoda, Holly L. Grammer