Abstract: Contact lenses, such as hydrogel contact lenses, are described. The present contact lenses include a lens body that is the reaction product of a polymerizable composition. The polymerizable composition includes one or more monomers and a crosslinker that crosslinks the one or more monomers during polymerization. The polymerization of the one or more monomers occurs in the presence of a hydrophilic polymer that is present in the polymerizable composition, which comprises a polymer of 2-methacryloyloxyethyl phosphorylcholine. The present lenses are capable of releasing the hydrophilic polymer from the contact lens for prolonged periods of time and also have a reduced surface friction compared to similar lenses without the hydrophilic polymer. The present invention also relates to packaging systems for use with such lenses and methods of producing such lenses.

Abstract: Described are contact lenses having photochromic materials within the central or pupillary area of the lens and methods for manufacturing such lenses. In one method, a photochromic amount of at least one photochromic material is added to the pupillary region of a casting mold containing a polymerizable monomer that can be at least partially cured before and/or after the addition. Another method involves providing an amount of polymerizable photochromic monomer for the pupillary region and an amount of polymerizable non-photochromic monomer for the remainder of the contact lens in a casting mold. The photochromic and non-photochromic monomers can differ by their degree of polymerization, viscosity and/or density.

Abstract: A polymer comprising hydrophilic and hydrophobic properties is provided. The polymer can be formed into a hydrogel capable of being used as a contact lens. The lens can exhibit high water content such as for example more than 70 wt. % for biocompatibility and structural stability for handling. The hydrophilic portion can be 2,3-dihydroxypropyl methacrylate (GMA) and the hydrophobic portion can be 2-methoxyethyl methacrylate (MOEMA). Additionally, the lens can also include N,N-dimethylacrylamide (NN-DMA). Lens can be prepared and formed by molding including a cast molding process or a half cast molding process.

Abstract: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

Abstract: The present invention provides an actinically or thermally curable ink for making colored silicone hydrogel contact lenses. The ink of the invention comprises at least one colorant, a solvent and a binder polymer including ethylenically unsaturated groups and segments derived from at least one silicone-containing vinylic monomer or macromer. The ink of the invention is characterized by having capability to be cured actinically or thermally to form a colored coat on a silicone hydrogel contact lens, wherein the colored coat has good adhesion to the silicone hydrogel contact lens without being covalently attached to the lens material of the contact lens. The invention also provides methods for making colored silicone hydrogel contact lenses.

Abstract: Biomedical devices are provided herein which are formed from a polymerization product of a mixture comprising (a) a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers; and (b) a biomedical device-forming comonomer.

Abstract: The present disclosure provides a method of forming a removable protective coating on a hydrophobic surface of an ophthalmic lens element. The method includes providing an ophthalmic lens element having a hydrophobic surface. A non-aqueous coating composition is applied so as to coat at least part of the hydrophobic surface. The composition includes a film forming coating polymer and a compatible non-aqueous solvent. A substantial portion of the solvent is removed from the composition to form a removable protective coating on the ophthalmic lens element that adheres to the hydrophobic surface. The disclosure also provides a removable protective coating, and an ophthalmic lens element having the coating.

Abstract: A dispersed ingredient having metal-oxygen bonds which is obtained by hydrolyzing a metal alkoxide in an organic solvent in the absence of an acid, a base, and/or a dispersion stabilizer, either with 0.5 to less than 1 mol of water per mol of the metal alkoxide or at ?20° C. or lower with 1.0 to less than 2.0 mol of water per mol of the metal alkoxide. In the organic solvent, the dispersed ingredient is stably dispersed without aggregating. Use of the dispersed ingredient enables a thin metal oxide film and a homogeneous organic/inorganic composite to be produced at a temperature as low as 200° C. or below.

Abstract: Silicone hydrogel contact lenses having ophthalmically acceptable surface wettabilities are obtained from pre-extracted polymerized silicone hydrogel contact lens products produced from a polymerizable composition comprising a combination of particular components. The silicone hydrogel contact lenses can be obtained from non-polar resin based contact lens molds and without surface treatments or an interpenetrating polymeric network of a polymeric wetting agent. Related lens products, polymerizable compositions, and methods are also described.

Abstract: A method for making an optical element comprises polymerizing a first monomer to form a first polymer, the first polymer having a spatially varying degree of cure that provides a predetermined refractive index profile; and polymerizing a second monomer in the presence of the first polymer to form a second polymer intermixed with the first polymer, the second polymer stabilizing the first polymer and the refractive index profile.

Abstract: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

Abstract: A method for in-mold coating of an injection molded thermoplastic lens that resides in an injection molding machine oriented to a horizontal parting line. An optical lens is initially formed by injecting molten thermoplastic resin into an edge-gated lens-forming cavity held closed under a primary clamp force. The mold is opened at a time when the lens is rigid enough to retain its shape. An unpressurized full metered charge of coating is applied onto the center of the lens. The coating is co-molded by ramping up the clamp force from zero to a secondary clamp force less than the primary clamp force to compress the coating into a uniformly thick, fringe-free layer.

Abstract: A chromene compound of this invention, as shown in the following formula: characterized by having an indeno(2,1-f)naphtho(1,2-b)pyran structure as a basic structure, and having a substituent which is a substituted or unsubstituted aryl group such as methoxyphenyl group, or a substituted or unsubsterituted heteroaryl group such as thienyl group bonding to a carbon atom at the seventh position of the indeno(2,1-f)naphtho(1,2-b)pyran structure. The photochromic compound exhibits a color tone of a neutral tint when it develops a color, features a high color-developing sensitivity and a high fading rate, and has a good photochromic resistance.

Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials contain a functionalized alkylphenol ethoxylate to reduce glistenings.

Abstract: The present invention relates to a method of preparing a transparent moulding comprising a blend of a first thermoset polymeric material forming the matrix of said moulding, and of a second polymeric material dispersed within said first material, said method comprising at least the following stages: i) preparation of a liquid polymerizable mixture by dissolving said second polymeric material in a thermosetting polymerizable composition that is a precursor of said first thermoset polymeric material, ii) filling of a mould with the liquid polymerizable mixture obtained in stage i), iii) cooling of the liquid polymerizable mixture in the mould to a temperature T less than or equal to 0° C., iv) initiation of the polymerization of said cooled liquid polymerizable mixture at a temperature T? less than or equal to 0° C.

Abstract: The present invention relates to tinted optical lenses and to methods of manufacturing tinted optical lens. This invention relates to a method for tinting optical lenses using an ink receptor film. The method of the invention allows a good transfer of the color to the substrate which represents the support of lens, a good final coloration of the substrate with good color homogeneity. The invention relate also to a method of tinting optical lenses, using the said ink receptor film which is applied onto a primer layer coating the substrate of the lens. The ink receptor material comprises an inorganic filler and an water-based emulsion. Preferably the ink receptor material also comprises a water-soluble polymer, a modified cationic polymer and a carrier able to accelerate the absorption of the ink into the substrate.

Abstract: Chromophores that absorb both UV and short wavelength visible light are disclosed. The chromophores are particularly suitable for use in intraocular lens materials.

Abstract: High refractive index copolymers suitable for use in ophthalmic devices are disclosed. The copolymers comprise two or more aryl hydrophobic monomers and a non-polymerizable propylene oxide-ethylene oxide-propylene oxide block copolymer surfactant having a molecular weight of approximately 3600 and approximately 40% ethylene oxide units by weight. The copolymers have a reduced tendency to form glistenings when stored in water at physiological temperatures compared to similar copolymers lacking the non-polymerizable surfactant.

Abstract: A gel composition is provided, which in addition to being able to expect that various properties attributable to polyrotaxane will be retained, easily ensures stability, has superior shock absorbability and facilitates control of refractive index. The present invention provides a gel composition comprising a material having a network structure containing a polyrotaxane and a non-aqueous solvent, applications of the gel composition, and a process for preparing the gel composition.

Abstract: A composition adapted for use in an in-situ coating process for coating an optical surface for ophthalmic applications. A coating composition according to the present invention includes at least one multifunctional acrylate compound which is cured onto a heated surface with controlled coating distribution in an ophthalmic injection mold. For example, the composition may include an acrylic base cured with an initiator, e.g., t-butyl perbenzoate, and may further include at least one catalyst and at least one metal salt. An acrylic base according to the present invention may include a combination of monofunctional and/or multifunctional acrylate and/or methacrylate compounds.

Abstract: The present invention relates to mixtures for preparing transparent plastics, encompassing a) compounds of the formula (I) and (II) where each R1, independently of the others, is hydrogen or a methyl radical, each R2, independently of the others, is a linear or branched, aliphatic or cycloaliphatic radical, or a substituted or unsubstituted aromatic or heteroaromatic radical, and each of m and n, independently of the other, is a whole number greater than or equal to 0, where m+n>0, and b) at least one monomer (A) capable of free-radical polymerization with a molar mass of at least 150 g/mol, which contains at least two terminal olefinic groups, where at least two of the olefinic groups of the monomer (A) have, in the ?- and/or ?-position with respect to the olefinic group, atoms which differ in nature and/or number, in the radical which connects the at least two olefinic groups.

Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymer compositions comprise polymerized silicon-containing monomers end-capped with polymerizable cationic hydrophilic groups.

Abstract: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

Abstract: The present invention relates to wettable silicone hydrogels comprising the reaction product of at least one siloxane containing component and at least one reactive, hydrophilic polymeric internal wetting agent. The present invention further relates to silicone hydrogel contact lenses comprising at least one oxygen permeable component, and an amount of reactive, hydrophilic polymeric internal wetting agent sufficient to impart wettability to said device.

Abstract: The present invention provides optic portions, intraocular lenses, and polymers for use in manufacturing optic portions and intraocular lenses. The optic portions include a polymer that comprises (a) one or more alkoxyalkyl methacrylate monomers and/or one or more alkoxyalkyl acrylate monomers that are incorporated in the polymer; (b) one or more hydroxyalkyl methacrylate monomers and/or one or more hydroxyalkyl acrylate monomers that are incorporated in the polymer; and (c) optionally, one or more crosslinking agents that are incorporated in the polymer.

Abstract: A polysiloxane copolymer that is useful for forming biomedical devices comprises blocks (I) and (II) and is terminated at each end with an ethylenically unsaturated radical: (*Dii*Diol*Dii*PS)x ??(I) (*Dii*PS)y ??(II) wherein: each Dii is independently a diradical residue of a diisocyanate; each Diol is independently a diradical residue of a diol having 1 to 10 carbon atoms; each PS is independently a diradical residue of a polysiloxane-containing diol or diamine; each * is independently —NH—CO—NH—, —NH—COO— or —OCO—NH—: x represents the number of blocks (I) and is at least 2, and y represents the number of blocks (II) and is at least 1.

Abstract: This invention relates to solutions for packaging ophthalmic devices comprising at least one antimicrobial metal salt which prevent the loss of said antimicrobial metal salt during autoclaving and storage.

Abstract: High refractive index and optically clear copoly(carbosilane and siloxane) elastomers and ophthalmic lenses made therefrom are provided. The elastomers are comprised of copolymers having carbosilane repeat units and siloxane repeat units. The copolymers and ophthalmic lenses of the present invention have a high refractive index and excellent folding recoverability.

Abstract: Super-low fouling sulfobetaine and carboxybetaine materials, super-low fouling surfaces and methods of making the surfaces coated with sulfobetaine and carboxybetaine materials, and devices having the super-low fouling surfaces.

Abstract: Provided are surface modified contact lenses formed from one or more fumaric- or itaconic-containing prepolymers having reactive functionality that is complimentary to reactive hydrophilic polymers.

Abstract: A polymeric material having enhanced oxygen permeability and ion and water transport rates comprises units of a first monomer and a second monomer, which comprises linear poly(ethylene oxide), cyclic poly(ethylene oxide), or combinations thereof. Medical devices, such as ophthalmic devices, are made from such polymeric materials.

Abstract: An intraocular lens with an ordered polymer system contained within a lens capsule or a membrane in the lens capsule. The ordered polymer system includes at least one negatively charged copolymer comprising hydrophilic groups, anionic groups and hydrophobic groups, and at least one positively charged copolymer comprising hydrophilic groups, cationic groups and hydrophobic groups. The at least one negatively charged copolymer and the at least one positively charged copolymer are associatively arranged through non-covalent interactions in the lens capsule or the membrane.

Abstract: An inkjet ink composition having a binder including an aqueous dispersion of polymer particles, the polymer including, as polymerized units, (a) from 0 to 1 wt. % monoethylenically unsaturated acid monomer, based on polymer weight; and (b) monomer of the formula CH2?C(R1)—CON(R2)(R3) wherein R1?H, CH3 or C2H5 and R2 and R3 are independently selected from C1-C6 saturated alkyl and cycloalkyl groups; and wherein the total of (a) and (b) is at least 0.1 wt % monomer based on the polymer weight. The binder may be a copolymer of ethyl acrylate and acrylamide. An inkjet ink composition including the inkjet ink binder, a colorant, and a liquid medium is also provided.

Abstract: Described are contact lenses having photochromic materials within the central or pupillary area of the lens and methods for manufacturing such lenses. In one method, a photochromic amount of at least one photochromic material is added to the pupillary region of a casting mold containing a polymerizable monomer that can be at least partially cured before and/or after the addition. Another method involves providing an amount of polymerizable photochromic monomer for the pupillary region and an amount of polymerizable non-photochromic monomer for the remainder of the contact lens in a casting mold. The photochromic and non-photochromic monomers can differ by their degree of polymerization, viscosity and/or density.

Abstract: The present invention relates to a process for the purification of silicone containing compounds via supercritical fluid extraction. Specifically, the present invention relates to a process comprising the steps of contacting at least one silicone containing compound with a supercritical fluid having a density of between about 0.2 and about 0.8 g/ml, decreasing said density so that two phases are formed a first phase comprising said at least one silicone containing compound and a second phase comprising at least one impurity and separating said second phase from said first phase.

Abstract: Spirotetrathiocarbamates (STOCs) or oxa substituted compounds (SOTOCs) of Formula I: Formula (I) or bisSTOC or bisSOTOC compounds of Formula II: Formula (II) wherein X1, X2, X3, X4, X5, X6, X7, and X8, are independently O or S; and preferably at least two and up to all four of X1, X2, X3 and X4, and at least two and up to all four of X5, X6, X7, and X8 are sulfur; Z is —CmR22m wherein m=1 to 4; —C(R2)2SC(R2)2—, C(R2)2SSC(R2)2—, or —C(R2)OC(R2)2; n is from 0 to 4; M is selected from CH2Cl, CH2SC(O)R1, CH2SC(S)R1, CH2S(CH2CH2S)qH wherein q is 0, 1 or 2; —CR2?CH2, —CH2OC(O)CR2?CH2, CH2N?C?S, CH2N?C?O, CH2NR2H, CH2OH, CH2SCH2CH2CR2?CH2, phenyl, C(R2)phenyl, furan, thiophene, halogen, C3-C6 cycloalkyl, C3-C6 heretocyclics, thiol, H, (III) or (IV) wherein A is S, O or phenyl; x is 0 or 1; R1 is C1-C22 alkyl; and R2 is H or C1-C22 alkyl have excellent optical properties. Methods for preparing these compositions and optical lenses prepared from the compounds are also provided.

Abstract: Disclosed are ophthalmic device materials having improved light transmission characteristics. The materials contain a combination of certain UV absorbers and blue-light absorbing chromophores.

Abstract: The present invention is related to water-based inks for making colored hydrogel contact lenses, in particular, colored HEMA-based hydrogel contact lenses. The ink of the invention comprises at least one colorant, water, and a water-soluble and actinically-curable binder polymer which is a vinyl group-terminated polyurethane polymer, a vinyl group-terminated polyurea binder polymer, or a mixture thereof. Also, the ink of the invention is characterized by having a viscosity greater than 50 centipoise (cps), a prolonged stability, and a good adhesion to a HEMA-based hydrogel contact lens. The ink of the invention preferably further has a good compatibility with a HEMA-based hydrogel material, and/or good transferability from a mold to a HEMA-based hydrogel contact lens made in the mold. The present invention is also related to a method for making colored hydrogel contact lenses using an ink of the invention.

Abstract: In one aspect, the invention relates to hydrolysis-resistant silicone compounds. In particular, disclosed are sterically hindered hydrolysis-resistant silicone compounds and improved purity hydrolysis-resistant silicone compounds. Also disclosed are processes for making hydrolysis-resistant silicone compounds; the products of the disclosed processes; compositions and polymers comprising the disclosed compounds and products of the disclosed processes; and ophthalmic lenses, for example contact lenses, intraocular lenses, artificial cornea, and spectacle lenses, comprising the disclosed compositions, disclosed polymers, disclosed compounds, and products of the disclosed processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The invention relates to a method for producing glycerol monomethacrylate (GMMA).

Abstract: This invention provides an ophthalmic lens of high tensile elongation (i.e., that does not break easily). It is an ophthalmic lens comprising, as a polymerization component, monomers represented by formula (a) below: wherein, in formula (a), R1 is H or a methyl group; R2 is a group that is selected from alkyl groups with 1 to 8 carbon atoms, aralkyl groups with 7 to 12 carbon atoms and aryl groups with 6 to 10 carbon atoms; L1 is a substituent that is selected from ethylene groups, 1,2-propylene groups, 1,3-propylene groups and 1,4-butylene groups; and L2 is a substituent that is selected from methylene groups, ethylene groups, 1,2-propylene groups, 1,3-propylene groups and 1,4-butylene groups.

Abstract: Disclosed are soft, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain an aryl acrylic hydrophobic monomer as the single principal device-forming monomer and a tack-reducing macromer additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.

Abstract: Hydrophilic, arylsiloxy-containing macromonomers have at least a terminal hydrophilic group attached to an arylsiloxy group. The aryl groups attached to siloxy groups can be substituted with other hydrophilic groups. Polymers comprising such hydrophilic, arylsiloxy-containing macromonomers avoid or reduce the risk of forming vacuoles of absorbed water. Furthermore, such polymers have high refractive index, and, thus, are advantageously used for making ophthalmic devices, such as intraocular lenses, contact lenses, corneal rings, corneal inlays, and keratoprostheses.

Abstract: The present invention relates to new hydrogels with improved mechanical properties and methods of their preparation. The hydrogels are formed from hydrophilic polymers having function hydroxyl groups and have low elasticity modulus typically less than about 10 kPa, a tensile strength above 1 Mpa, an elongation above 50% which makes suitable as medical implants, in particular intraocular lenses. The hydrogels are prepared by a crosslinking method with a comparatively low concentration of hydrophilic polymer of a sufficiently high molecular weight dissolved in a good solvent.

Abstract: An interpenetrating polymer network (IPN) composition and a process for the manufacture of hydrogel contact lens using the invention material. The polymeric materials are formed by polymerization of: (1) an unsaturated alkyl(meth)acrylate or its derivatives such as 2-hydroxyethyl methacrylate as the principle monomer; (2) optionally vinyl containing comonomer(s) to enhance the resulting hydrogel water absorbing capability; (3) polymerizable multi-functional crosslinking agent(s); (4) an irradiation initiator and/or thermal initiator; (5) optionally other additives to impart the resulting hydrogel specific properties such as ultra-violet blocking ability and handling colors; in the presence of a soluble, hydrophilic IPN agent such as polyvinylpyrrolidone (PVP) or poly-2-ethyl-2-oxazoline (PEOX) with a specific molecular weight range.

Abstract: The present invention provides a radiation-curable prepolymer. The radiation-curable prepolymer of the invention is prepared by reacting an isocyanate-capped polyurethane with an ethylenically unsaturated amine or an ethylenically unsaturated monohydroxy compound or a mixture thereof, wherein the isocyanate-capped polyurethane is a copolymerization production of: (a) at least one polyalkylene glycol; (b) at least one branching agent having at least three hydroxy groups; and (c) at least one di- or polyisocyanate. The radiation-curable prepolymer of the invention can find use in economically producing contact lenses which have durable, highly elastic soft contact lenses with desired physical properties. In addition, the present invention provides method for making a radiation-curable prepolymer of the invention and for making a medical device, preferably an ophthalmic device, more preferably a contact lens.

Abstract: A polymerizable resin material for making a plastic lens includes bisphenol A ethoxylate (1 to 4) dimethacrylate and benzylmethacrylate, and, optionally, one or more stabilizing monomers, preferably selected from trimethylolpropane trimethacrylate, isobornyl methacrylate, ethoxylate nonyl phenol acrylate, ethyoxylate nonyl phenol, and/or 2-phenoxyethyl methacrylate esters. The polymerizable resin material is cured when exposed to heat or visible and/or UV light for a period of about two minutes or less.

Abstract: A process for producing intraocular lenses (IOLs) capable of absorbing blue light and ultraviolet light using photo curing. Intraocular lenses so produced block blue light and ultraviolet light from reaching the retina of an eye implanted with the IOL. By blocking blue light and ultraviolet light from reaching the retina, the IOL thereby prevents potential damage to the retina.

Abstract: Ophthalmic lenses, such as corneal contact lenses, include a lens body made of a composition including a lens body made of a composition including a first crosslinked polymer material which is water swellable, and a second polymeric material, other than the first material, selected from water soluble polymeric materials, water swellable polymeric materials and mixtures thereof. The second material is physically immobilized by the first material. Such lenses provide increased water retention and/or increased water content and/or increased modulus and/or reduced friction which increases lens wearer comfort. Compositions and methods for providing such lenses and compositions are also provided.

Abstract: A plastic lens which absorbs ultraviolet light having wavelength of about 400 nm and suppresses coloring and a process for producing the lens. A plastic lens may be made from a composition which comprises (A) a lens material monomer comprising diethylene glycol bisallylcarbonate, (B) an organic peroxide-based polymerization initiator, (C) a cobalt compound represented by at least one of CoO.Al2O3 and Co.Al2O4, and (D) at least one ultraviolet light absorbent selected from 2-hydroxy-4-octyloxy-benzophenone, 2,2?,4,4?-tetrahydroxy-4-octyloxybenzophenone and 2,2?,4?-trihydroxy-4-octyloxybenzophenone. A process for producing a plastic lens comprises mixing component (A), component (B), a cobalt fluid comprising component (C) in a dispersant and component (D) and a step of casting the mixed fluid into a mold and polymerizing the fluid to obtain a plastic lens.