Non-thrombogenic Patents (Class 523/112)
  • Patent number: 10098725
    Abstract: An endovascular treatment aiding device is an endovascular treatment aiding device including a flexible shaft; a filter fixed to the shaft such that an opening section is formed in the proximal side, wherein a ring having elastic restoring force is fixed to the opening section, which filter is capable of being opened and closed in an umbrella-like manner, and is in a conical shape having a bottom formed by the ring when the filter is open; and a linear supporting member fixed to the ring and a part of the shaft such that they are connected to each other, which linear supporting member enables closing the filter by application of an external force to the proximal side; wherein coils formed with a radio-opaque material is/are wound around the ring; when the filter is closed, a plurality of mountains pointing toward the distal side and a plurality of valleys pointing toward the proximal side are alternately formed in the ring to form a shape in which the mountains are positioned close to each other, and the vall
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: October 16, 2018
    Assignees: Toray Industries, Inc.
    Inventors: Kanji Inoue, Takahiro Yagi, Masaki Fujita, Koji Kadowaki, Kazuhiro Tanahashi
  • Patent number: 9949484
    Abstract: Antimicrobial quaternized polyurethane materials and methods of forming and using the materials are disclosed. The quaternized polyurethane antimicrobial materials may be synthesized from one or more diisocyanates and one or more diols or triols. The quaternized polyurethane materials may be stand alone or coated onto other surfaces, such as medical devices, table tops, air/water filters, or the like to provided desired antimicrobial devices and surfaces.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: April 24, 2018
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventor: Daewon Park
  • Patent number: 9782569
    Abstract: A medical device, such as a medical wire, which includes a coating applied to the surface of the medical wire. The coating includes a base layer bonded to the surface of the medical wire and an at least partially transparent low-friction top coat applied to the base layer. The base layer includes heat activated pigments that change color when heated above a color shifting temperature. In one embodiment, the color of the pigment in one area contrasts with the color of the pigment in an adjacent area without otherwise affecting the low-friction surface of the coating. The areas of different color created in locations along the length of the low-friction coated medical wire form markings which, as an example, enable a surgeon to determine the length of the medical wire inserted into a body by observing the markings on the portion of the marked medical wire located exterior to the body.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: October 10, 2017
    Assignee: Innovatech, LLC
    Inventor: Bruce Nesbitt
  • Patent number: 9694117
    Abstract: A medical material that is excellent in antithrombogenicity even under a severe use condition in which thrombi are easily formed, is provided. The medical material contains a water-insoluble copolymer including a repeating unit (A) (which is derived from acryloylmorpholine, for example) and a repeating unit (B) (which is derived from methoxyethyl acrylate, for example), in which the water-insoluble copolymer has 5 mole % to 20 mole % of the repeating unit (A) with respect to all constituent units of the copolymer.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: July 4, 2017
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Takao Anzai
  • Patent number: 9339770
    Abstract: A semipermeable gas separation membrane is plasma deposited from liquid organosiloxane monomer having at least three silicon atoms and an alpha hydrogen atom. The semipermeable membrane may be employed as a gas-selective membrane in combination with a porous substrate.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: May 17, 2016
    Assignee: Applied Membrane Technologies, Inc.
    Inventor: Ashok K. Sharma
  • Patent number: 9241787
    Abstract: Methods and apparatus for an intraocular lens with a proofed surface are disclosed. The proofed surface functions as a barrier to fluid diffusion inside the material and within vacuoles. By preventing the interstitial filling of fluid, the formation of spots inside the polymer matrix is inhibited or reduced. The proofed surface of the intraocular lenses is a highly stable re-assembled surface without any coating or grafting.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: January 26, 2016
    Assignee: SIFI MedTech Srl
    Inventors: Maria Cristina Curatolo, Elena Anastasi, Rosarío Occhipinti Amato
  • Patent number: 8912247
    Abstract: Improved methods for preparing polyethylene glycol fumarate) are disclosed. Methods for chemically crosslinking or photocross-linking hydrophilic polyethylene glycol fumarate) with hydrophobic polymers such as poly(propylene fumarate) (PPF) and poly(caprolactone fumarate) (PCLF) to form various hydrogels (FIG. 1) with controllable hydrophilicity are also disclosed. The hydrogels are useful in the fabrication of injectable and in-situ hardening scaffolds for application in skeletal reconstruction. An injectable material including the hydrogels may be useful in controlled drug release.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: December 16, 2014
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Shanfeng Wang, Lichun Lu, Michael J. Yaszemski
  • Patent number: 8877830
    Abstract: The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material or during polymerization of a polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides mixtures for making crosslinked polymeric materials, methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention. The mixtures of the invention may be dental restorative compositions used for forming dental restorative materials.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: November 4, 2014
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Christopher N. Bowman, Christopher Kloxin, Hee Young Park, Diana Leung
  • Patent number: 8859706
    Abstract: The invention relates to a bioactive hydrogel as a hybrid material of heparin and star-branched polyethylene glycol with functionalized end groups, wherein the heparin is bound directly by reaction of the carboxyl groups activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimides/N-hydroxysulfosuccinimide (EDC/s-NHS) with the terminal amino groups of the polyethylene glycol covalently by amide bonds.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: October 14, 2014
    Assignee: Zetascience GmbH
    Inventors: Carsten Werner, Uwe Freudenberg, Dorit Meinhold, Marie-Francoise Gouzy, Petra Welzel
  • Publication number: 20140235748
    Abstract: The object of the present invention is achieved by providing a copolymer, in particular, a block copolymer which has excellent coating formation ability, adhesive properties to a substrate, and does not adsorb protein; an antithrombotic coating agent which has superior antithrombotic properties and adhesive properties to a substrate to those of the conventional antithrombotic coating agent; and a medical instrument which is obtained by coating the antithrombotic coating agent, and the block copolymer includes a polymer (A) containing a (meth)acrylic ester monomer and a polymer (B) containing a (meth)acrylamide monomer and has excellent coating formation ability and high adhesive properties to a substrate.
    Type: Application
    Filed: August 10, 2012
    Publication date: August 21, 2014
    Applicants: DIC CORPORATION, KAWAMURA INSTITUTE OF CHEMICAL RESEARCH
    Inventors: Kazutoshi Haraguchi, Kazuomi Kubota, Tooru Takehisa, Tetsuo Takada, Noriko Santou
  • Patent number: 8697771
    Abstract: Disclosed herein are biocompatible coatings for a substrate, the biocompatible coating including at least one polyanionic/polycationic bilayer including at least one nitric oxide generating moiety, wherein the polyanionic/polycationic bilayer has a layer of a polycationic polymeric material; and a layer of polyanionic material capable of non-covalently bonding to the polycationic polymeric material. Devices incorporating such coatings, and methods of making and using such coatings are also disclosed herein.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: April 15, 2014
    Assignee: The Regents of the University of Michigan
    Inventors: Mark E. Meyerhoff, Jun Yang
  • Patent number: 8552088
    Abstract: A cement for dental use, containing a first agent and a second agent, wherein both of the first agent and the second agent contain a polymerizable monomer (a) and a filler (b), wherein the first agent and/or the second agent further contains a photopolymerization initiator (c), wherein further as a chemical polymerization initiator (d), either one of the first agent and the second agent contains an oxidizing agent (f) and the other contains a reducing agent (g), the oxidizing agent (f) and the reducing agent (g) constituting a redox polymerization initiator, wherein the photopolymerization initiator (c) contains an ?-diketone, and the photopolymerization initiator (c) is contained in a total amount of from 0.010 to 0.100 parts by weight, based on 100 parts by weight of the total amount of the polymerizable monomer (a), wherein the chemical polymerization initiator (d) is contained in a total amount of from 0.
    Type: Grant
    Filed: December 25, 2008
    Date of Patent: October 8, 2013
    Assignee: Kuraray Noritake Dental Inc.
    Inventors: Hiroki Shinoda, Mitsuru Takei, Hidemi Nakayama
  • Patent number: 8524798
    Abstract: Compositions for use in treating and repairing orthopedic defects are provided. The compositions are especially useful for performing percutaneous vertebroplasty, percutaneous kyphoplasty and other procedures. When cured, the compositions are relatively solid but compressible, and prior to curing are viscous liquids with a low enough viscosity to fill voids in cavities such as voids within fractured vertebrae. Optionally, the properties of a composition according to the invention can be adjusted taking into account the hardness and density of the orthopedic structure to be repaired. Also disclosed are devices and methods for using the compositions, and a kit containing components for forming and utilizing the composition.
    Type: Grant
    Filed: September 25, 2007
    Date of Patent: September 3, 2013
    Inventors: Linda M. Trebing, Ralph W. Carmichael
  • Patent number: 8507629
    Abstract: A production method of the present invention is a production method of an organic polymer containing two or more organic ring structures and a chain structure threading through the organic ring structures. This method includes a polymerization step of forming the organic polymer, in which the organic ring structures, which are restricted from moving, are disposed at each of a particular constitutional unit, by polymerizing at least one type of monomers each of which has no ionic functional group that releases a metal ion. The above at least one type of monomers include a monomer (M) containing the organic ring structure and a chain component threading through the organic ring structure.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: August 13, 2013
    Assignee: Panasonic Corporation
    Inventors: Takayuki Takeuchi, Norihisa Mino, Nobuaki Kambe, Jun Terao
  • Patent number: 8501831
    Abstract: The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: August 6, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Shrojalkumar Desai, Marlene C. Schwarz, Mark Boden, Mohan Krishnan, Michael C. Smith, Frederick H. Strickler, Daniel J. Cooke
  • Patent number: 8263681
    Abstract: The invention features a dental composition containing a polycyclic aromatic compound, such as 2-ethyl 9,10-dimethoxy anthracene (EDMOA), in an amount that provides the composition with fluorescence mimicking that of natural teeth.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: September 11, 2012
    Assignee: 3M Innovative Properties Company
    Inventors: Bradley D. Craig, Gregory A. Kobussen
  • Patent number: 8053490
    Abstract: A dental filler and dental resin restorative composition containing the dental filler is provided. The dental filler is prepared by pre-treating an acid-reactive filler with a polymerizable monomer or oligomer pre-treatment chemical having at least one acid or acid-precursor functional group, at least one polymerizable unsaturated carbon-carbon bond, and a molecular weight of about 1,000 grams per mole or less.
    Type: Grant
    Filed: May 18, 2009
    Date of Patent: November 8, 2011
    Assignee: Pentron Clinical Technologies, LLC
    Inventors: Weitao Jia, Shuhua Jin
  • Patent number: 8008365
    Abstract: The present invention discloses methods for enhancing the wear-resistance of polymers, the resulting polymers, and in vivo implants made from such polymers. One aspect of this invention presents a method whereby a polymer is irradiated, preferably with gamma radiation, then thermally treated, such as by remelting of annealing. The resulting polymeric composition preferably has its most oxidized surface layer removed. Another aspect of the invention presents a general method for optimizing the wear resistance and desirable physical and/or chemical properties of a polymer by crosslinking and thermally treating it. The resulting polymeric compositions is wear-resistant and may be fabricated into an in vivo implant.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: August 30, 2011
    Assignee: Orthopaedic Hospital
    Inventors: Fu-Wen Shen, Harry A. McKellop, Ronald Salovey
  • Patent number: 8003709
    Abstract: The present invention discloses methods for enhancing the wear-resistance of polymers, the resulting polymers, and in vivo implants made from such polymers. One aspect of this invention presents a method whereby a polymer is irradiated, preferably with gamma radiation, then thermally treated, such as by remelting of annealing. The resulting polymeric composition preferably has its most oxidized surface layer removed. Another aspect of the invention presents a general method for optimizing the wear resistance and desirable physical and/or chemical properties of a polymer by crosslinking and thermally treating it. The resulting polymeric compositions is wear-resistant and may be fabricated into an in vivo implant.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: August 23, 2011
    Assignee: Orthopaedic Hospital
    Inventors: Fu-Wen Shen, Harry A. McKellop, Ronald Salovey
  • Patent number: 7977403
    Abstract: The present invention relates to compositions comprising silicone elastomers and antiseptics in homogeneous distribution, to processes for the preparation thereof and to uses thereof, for example, in medical articles.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: July 12, 2011
    Assignee: Bayer Innovation GmbH
    Inventors: Marc Lohrmann, Heinz Pudleiner, Joachim Hyner
  • Publication number: 20110144229
    Abstract: Disclosed herein are biocompatible coatings for a substrate, the biocompatible coating including at least one polyanionic/polycationic bilayer including at least one nitric oxide generating moiety, wherein the polyanionic/polycationic bilayer has a layer of a polycationic polymeric material; and a layer of polyanionic material capable of non-covalently bonding to the polycationic polymeric material. Devices incorporating such coatings, and methods of making and using such coatings are also disclosed herein.
    Type: Application
    Filed: August 19, 2009
    Publication date: June 16, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Mark E. Meyerhoff, Jun Yang
  • Publication number: 20110092613
    Abstract: Certain embodiments of the invention include forming a material in situ by introducing into a space within a patient a water soluble polymer precursor of at least about 10,000 molecular weight solubilized in a flowable aqueous solution. Functional groups on the polymer precursor undergo covalent bonding in situ to form a solid and nonbiodegradable material having a swellability less than about 20% v/v and a Young's modulus of at least about 100 kPa within about 30 seconds to about 30 minutes of initiating a chemical reaction of the functional groups to form the solid material.
    Type: Application
    Filed: December 16, 2010
    Publication date: April 21, 2011
    Inventors: Farhad Khosravi, James Dreher
  • Patent number: 7776940
    Abstract: Hardenable and hardened dental compositions, and articles including such hardenable and hardened compositions, are provided. In some embodiments, the hardenable dental compositions include an acid-generating component and an acid-reactive component including one or more acid-reactive groups. Upon irradiating, and optionally heating, the hardened compositions are useful, for example, for reducing the bond strength of orthodontic appliances adhered to tooth structures with the hardened compositions.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: August 17, 2010
    Assignee: 3M Innovative Properties Company
    Inventors: Rajdeep S. Kalgutkar, Joan V. Brennan, Babu N. Gaddam
  • Patent number: 7709556
    Abstract: Absorbable radiation or radiochemically sterilized medical devices, including sutures, whose breaking strength and absorption profile can be modulated by controlling the total dose received during sterilization are disclosed.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: May 4, 2010
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 7655706
    Abstract: A polymethylmethacrylate bone cement with a liquid monomer component and a solid component contains in the monomer liquid, for example, 0.001-1.00 mass percent of a dye or dye mixture that is insoluble or poorly soluble in methacrylic acid methylester and, for example, 0.001-2.00 mass percent of a synthetically produced, protein-free, hydrophobic, low molecular or oligomeric solubilizer for the dye or dye mixture. The solubilizer preferably is liquid or pasty at room temperature. The monomer liquid is translucent at room temperature. Preferably, 0.001-1.00 mass percent of a dye or dye mixture that is insoluble or poorly soluble in methacrylic acid methylester and, preferably, 0.001-2.00 mass percent of a synthetically produced, protein-free, hydrophobic, low molecular or oligomeric solubilizer that is liquid or pasty at room temperature are homogeneously dissolved in the polymethacrylate or polymethylacrylate of the powder component.
    Type: Grant
    Filed: June 6, 2006
    Date of Patent: February 2, 2010
    Assignee: Heraeus Kulzer GmhH
    Inventors: Klaus-Dieter Kühn, Sebastian Vogt
  • Publication number: 20090306244
    Abstract: The present invention relates to the use of at least one compound selected from the group consisting of aliphatic compounds, alicyclic compounds and antioxidants for protecting a wetted hydrophilic coating which is sterilised by irridiation—in particular with ? radiation or E-beam radiation—in the presence of water, from loss of lubricity and/or loss of dry-out time as a result of a reaction between the coating and a radical and/or another reactive moiety formed by irriadiating the water.
    Type: Application
    Filed: May 15, 2007
    Publication date: December 10, 2009
    Inventor: Johannes Wilhelmus Belt
  • Publication number: 20090287072
    Abstract: The disclosure provides for a biocompatible, thromboresistant coating including a chalcogenide compound that induces nitric oxide formation; and a biocompatible matrix incorporating the chalcogenide compound. Devices incorporating such coatings, and methods of making and using such coatings are also disclosed herein.
    Type: Application
    Filed: December 1, 2006
    Publication date: November 19, 2009
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, MICHIGAN CRITICAL CARE CONSULTANTS, INC. (MC3)
    Inventors: Mark E. Meyerhoff, Wansik Cha, Sang-Yeul Hwang, Melissa M. Reynolds
  • Patent number: 7615582
    Abstract: A hydrophobic acidic group-containing polymeric monomer (a); a water-soluble polymeric monomer (b); water (c); a photopolymerization initiator (d); an aromatic tertiary amine (e) having an electron-withdrawing group; a cross-linkable polymeric monomer (f); and a basic compound (g) for producing a water-soluble salt through a reaction with a part of the hydrophobic acidic group-containing polymeric monomer (a) are included as essential compounding ingredients. A one-part dental adhesive composition that exhibits high adhesive strength and high storage stability in adhesion between a teeth, and more particularly enamel or dentine, and a dental repairing material, and more particularly a resin material, is provided.
    Type: Grant
    Filed: December 8, 2004
    Date of Patent: November 10, 2009
    Assignee: Kuraray Medical Inc.
    Inventors: Kazumitsu Nakatsuka, Naoki Nishigaki
  • Patent number: 7569621
    Abstract: A dyed polymethyl methacrylate bone cement is described which is characterized by at least the surface of the polymer particles of the powder component being coated partially or completely with a mixture of one or several dyes and a hydrophobic, low molecular or oligomeric organic coupling agent, such a quantity of coupling agent being present that the polymer particles can be visually recognized as not having swollen.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: August 4, 2009
    Assignee: Heraeus Kulzer GmbH
    Inventors: Klaus-Dieter Kühn, Sebastian Vogt
  • Patent number: 7537782
    Abstract: Resorbable polymer barrier membranes and methods of their applications are disclosed. In a broad embodiment, methods of governing bone growth, or preventing bone growth into a certain spatial area, includes the step of forming a spatial barrier with the present resorbable barrier membrane. The barrier membrane separates a bone-growth area and a non-bone-growth area, and prevents bone from growing into the non-growth area.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: May 26, 2009
    Assignee: Kensey Nash Corporation
    Inventors: Christopher J. Calhoun, G. Bryan Cornwall
  • Publication number: 20080133001
    Abstract: A composition-of-matter, comprising one or more plastically deformable fiber is disclosed. The plastically deformable fiber(s) comprise a first and a second composition, where the first composition comprises at least one generally nondistensible polymer and the second composition comprises at least one agent capable of modulating distensibility of the generally nondistensible polymer(s).
    Type: Application
    Filed: September 26, 2007
    Publication date: June 5, 2008
    Applicant: Nicast Ltd.
    Inventors: Alon Shalev, Alexander Dubson
  • Patent number: 7015262
    Abstract: Compositions, methods, devices and kits utilizing water-based hydrophilic coating formulations on medical implements. The composition for applying a coating comprises a sulfonated polyester, water, and a surface active agent. Methods for coating a medical implement comprise providing an aqueous dispersion comprising sulfonated polyester and surface active agent, contacting the medical implement with the aqueous dispersion, and drying the medical implement. Methods for acquiring a sample of bodily fluid from a patient comprise coating a needle with a sulfonated polyester, penetrating the needle into the patient, and drawing bodily fluid through the needle.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: March 21, 2006
    Assignee: LifeScan, Inc.
    Inventor: Koon-wah Leong
  • Patent number: 6867188
    Abstract: A non-irritating, non-allergenic and non-toxic bioadhesive composition can be obtained by providing a bioadhesive composition including a polyphenolic protein derived from byssus-forming mussels and, b) a polymer comprising carbohydrate groups. The bioadhesive composition does not contain any enzyme or chemical cross-linking agent. Optionally, the composition may contain an oxidising agent and/or a filler protein. Preferably, the composition is provided as a kit of at least two parts, namely the polyphenolic protein and the polymer comprising carbohydrate groups, respectively. The composition is especially suitable as an adhesive in ophthalmic therapy.
    Type: Grant
    Filed: December 14, 2000
    Date of Patent: March 15, 2005
    Assignee: BioPolymer Products of Sweden AB
    Inventors: Magnus Qvist, Hans Arne Hansson
  • Patent number: 6800670
    Abstract: The present invention discloses methods for enhancing the wear-resistance of polymers, the resulting polymers, and in vivo implants made from such polymers. One aspect of this invention presents a method whereby a polymer is irradiated, preferably with gamma radiation, then thermally treated, such as by remelting of annealing. The resulting polymeric composition preferably has its most oxidized surface layer removed. Another aspect of the invention presents a general method for optimizing the wear resistance and desirable physical and/or chemical properties of a polymer by crosslinking and thermally treating it. The resulting polymeric compositions is wear-resistant and may be fabricated into an in vivo implant.
    Type: Grant
    Filed: February 26, 2001
    Date of Patent: October 5, 2004
    Assignees: Orthopaedic Hospital, University of Southern California
    Inventors: Fu-Wen Shen, Harry A. McKellop, Ronald Salovey
  • Patent number: 6774157
    Abstract: A system for improving the biocompatibility of medical devices present within a patient's body. In one embodiment, the present subject matter reduces the thrombogenicity of polyurethane materials in contact with the blood of a patient. In one embodiment, the medical device has a polymeric wall and a coating of polyurethane, said coating of polyurethane having the same chemical composition throughout the thickness and displaying an antithrombogenic effect when inserted into a patient's body in contact with blood for a period of at least twenty-four hours. The present subject matter relates to the manufacture and treatment of polymeric materials that may be inserted as medical devices, accessories, implants or replacements into animal bodies, such as the human body.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: August 10, 2004
    Assignee: Transoma Medical, Inc.
    Inventor: Gregory Jay DelMain
  • Patent number: 6645483
    Abstract: A lubricant coating vehicle for medical devices used to reduce the coefficient of friction of such devices upon exposure thereof to moisture. The lubricant coating vehicle allows the introduction of a pharmacological additive having a release rate that is within acceptable pharmacokinetic criteria. The release rate is adjusted by utilizing different salt forms of the additive and adjusting the concentration of a urethane pre-polymer.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: November 11, 2003
    Assignee: Sherwood Services AG
    Inventor: Diane McGhee
  • Patent number: 6630580
    Abstract: The present invention provides an anti-thrombogenic and cellular-adhesion coating composition for blood-contacting surfaces. The coating comprises a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula I: wherein R1 is an C1-18 alkyl or C6-32 aryl group, each R2 is independently selected from the group consisting of C1-18 alkyl and C6-32 aryl, R3 is N or O, n is a number from 1 to 10, directly bound to a heparin molecule via covalent bonding, with an adhesive molecule directly bound to the heparin molecule. In one embodiment, the coating comprises benzyl-(1,2 dimethyl)disilyl heparin, wherein an adhesive molecule, such as fibronectin, is bound to the heparin.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: October 7, 2003
    Assignee: InnerDyne, Inc.
    Inventors: Ray Tsang, Shigemasa Osaki
  • Patent number: 6596699
    Abstract: A nucleic acid coating composition including a polyanion bound, directly or through one or more intermediates, to a medical device surface, with a condensate comprising a polycation and nucleic acid bound to the polyanion, devices incorporating such coating compositions, and methods for making. In one embodiment, a silyl-heparin complex is provided, bound to a medical device surface by hydrophobic interaction with the silyl moiety, with a polycation and nucleic acid condensate bound to the heparin by electrostatic interaction.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: July 22, 2003
    Assignee: BioSurface Engineering Technologies, Inc.
    Inventors: Paul O. Zamora, Ray Tsang, Shigemasa Osaki
  • Patent number: 6596024
    Abstract: Biocompatible prostheses, specifically, biocompatible heart valves, are described which comprise a blend of a polyurethane (PU) and a polysiliconeurethane (PSU). Preferably, the polyurethane is a polyetherurethane (PEU). More preferably, it is a polyetherurethane urea (PEUU). Such prostheses typically exhibit reduced mineralization or thrombosis and/or reduced biological degradation.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: July 22, 2003
    Assignee: Carbomedics Inc.
    Inventor: Joseph Andrew Chinn
  • Patent number: 6586493
    Abstract: Disclosed are hyaluronate-containing hydrogels having angiogenic and vascularizing activity and pre-gel blends for preparing the hydrogels. The hydrogels contain a cross-linked matrix of a non-angiogenic hyaluronate and a derivatized polysaccharide material, in which cross-linking is effected by free-radical polymerization. Kits for preparing the hydrogels are also disclosed.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: July 1, 2003
    Assignee: Arizona Board of Regents Arizona State University
    Inventors: Stephen P. Massia, Julie Trudel
  • Publication number: 20030065060
    Abstract: A non-irritating, non-allergenic and non-toxic bioadhesive composition can be obtained by providing a bioadhesive composition comprising a) a polyphenolic protein derived from byssus-forming mussels b) a polymer comprising carbohydrate groups. The bioadhesive composition does not contain any enzyme or chemical cross-linking agent. Optionally, the composition may contain an oxidising agent and/or a filler protein. Preferably, the composition is provided as a kit of at least two parts, namely the polyphenolic protein and the polymer comprising carbohydrate groups, respectively. The composition is especially suitable as an adhesive in ophthalmic therapy.
    Type: Application
    Filed: October 15, 2002
    Publication date: April 3, 2003
    Inventors: Magnus Qvist, Hans Arrie Hansson
  • Patent number: 6509104
    Abstract: An article having a non-thrombogenic surface and a process for making the article are disclosed. The article is formed by (i) coating a polymeric substrate with a crosslinked chemical combination of a polymer having at least two amino substituted side chains, a crosslinking agent containing at least two crosslinking functional groups which react with amino groups on the polymer, and a linking agent containing a first functional group which reacts with a third functional group of the crosslinking agent, and (ii) contacting the coating on the substrate with an antithrombogenic agent which covalently bonds to a second functional group of the linking agent. In one example embodiment, the polymer is a polyamide having amino substituted alkyl chains on one side of the polyamide backbone, the crosslinking agent is a phosphine having the general formula (A)3P wherein A is hydroxyalkyl, the linking agent is a polyhydrazide and the antithrombogenic agent is heparin.
    Type: Grant
    Filed: December 5, 2000
    Date of Patent: January 21, 2003
    Assignee: Michigan Biotechnology Institute
    Inventors: Zhi Heng Huang, William F. McDonald, Stacy C. Wright, Andrew C. Taylor
  • Publication number: 20020193475
    Abstract: A coating for a prosthesis, for example a stent, and a composition for forming the coating is disclosed. The coating can serve as a primer, allowing substances, such as polymers, to be effectively secured by the prosthesis. Alternatively, the coating can serve as a reservoir, allowing for the local and sustained release of a therapeutic substance to biological tissues. The composition can be formed from an ethylene vinyl alcohol copolymer and a dimethylsulfoxide solvent, with or without a therapeutic substance. Alternatively, the composition can be formed from an ethylene vinyl alcohol copolymer, a dimethylsulfoxide solvent, and a wetting fluid, with or without a therapeutic substance. The composition is applied to a surface of the prosthesis and essentially all of the dimethylsulfoxide solvent or dimethylsulfoxide solvent/wetting fluid is removed or allowed to evaporate to form the coating.
    Type: Application
    Filed: December 23, 1999
    Publication date: December 19, 2002
    Inventors: SYED F.A. HOSSAINY, DEBORRA SANDERS-MILLARE, JUDY A. GURUWAIYA, DANIEL A. CASTRO, SAMEER HARISH, STEVEN Z. WU
  • Patent number: 6495657
    Abstract: A polyamide and a process for preparing the polyamide are disclosed.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: December 17, 2002
    Assignee: Michigan Biotechnology Institute
    Inventors: William F. McDonald, Zhi Heng Huang, Stacy C. Wright, Morris Danzig, Andrew C. Taylor
  • Publication number: 20020188037
    Abstract: A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyalyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).
    Type: Application
    Filed: June 18, 2002
    Publication date: December 12, 2002
    Inventors: Stephen J. Chudzik, Timothy M. Kloke, Laurie R. Lawin, Ronald F. Ofstead, Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran
  • Patent number: 6458867
    Abstract: The present invention relates to a medical device comprising at least one tubular member having an inner surface and an outer surface. The inner surface of the tubular member is at least occasionally subjected to contact with at least one second surface. The tubular member therefore comprises a hydrophilic lubricious coating disposed on its inner surface to reduce the friction between the inner surface of the tubular member and the second surface which is caused by movement.
    Type: Grant
    Filed: September 28, 1999
    Date of Patent: October 1, 2002
    Assignee: SciMed Life Systems, Inc.
    Inventors: Lixiao Wang, Dachuan Yang, John Jianhua Chen, Yiqun Bruce Wang, Lance A. Monroe, Joel R. Munsinger
  • Publication number: 20020128345
    Abstract: A pressure sensitive hot melt adhesive composition which comprises a high molecular weight rubber and less than about 60 parts by weight of a liquid diluent, and has a G′ of less than about 15×104 dynes/cm2 at 10 rad/s at 25° C. is useful for adhesive skin application (e.g., surgical tape), including transdermal drug delivery applications.
    Type: Application
    Filed: December 29, 2000
    Publication date: September 12, 2002
    Inventor: Charles W. Paul
  • Publication number: 20020111393
    Abstract: The present invention provides a method for improving the bio-compatibility of devices, especially medical devices which are invasively present within a patient's body and the improved medical device. The present invention particularly reduces the thrombogenicity of polyurethane materials in contact with the blood of a living patient. The method comprises providing a bio-compatible medical device having polymeric polyurethane components thereon, exposing the polyurethane components of the medical device to polar solvents for said polymeric components while the polar solvents are in the vapor phase, and allowing said vapor phase exposure to continue for a sufficient amount of time as to reduce at least some irregular or sharp features on the surface of the polymeric component.
    Type: Application
    Filed: September 25, 2001
    Publication date: August 15, 2002
    Applicant: Data Sciences International, Inc.
    Inventor: Gregory Jay DelMain
  • Publication number: 20020068183
    Abstract: An article having a non-thrombogenic surface and a process for making the article are disclosed. The article is formed by (i) coating a polymeric substrate with a crosslinked chemical combination of a polymer having at least two amino substituted side chains, a crosslinking agent containing at least two crosslinking functional groups which react with amino groups on the polymer, and a linking agent containing a first functional group which reacts with a third functional group of the crosslinking agent, and (ii) contacting the coating on the substrate with an antithrombogenic agent which covalently bonds to a second functional group of the linking agent. In one example embodiment, the polymer is a polyamide having amino substituted alkyl chains on one side of the polyamide backbone, the crosslinking agent is a phosphine having the general formula (A)3P wherein A is hydroxyalkyl, the linking agent is a polyhydrazide and the antithrombogenic agent is heparin.
    Type: Application
    Filed: December 5, 2000
    Publication date: June 6, 2002
    Inventors: Zhi Heng Huang, William F. McDonald, Stacy C. Wright, Andrew C. Taylor
  • Publication number: 20020032434
    Abstract: A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).
    Type: Application
    Filed: November 21, 2001
    Publication date: March 14, 2002
    Inventors: Stephen J. Chudzik, Aron B. Anderson, Ralph A. Chappa, Timothy M. Kloke