Non-thrombogenic Patents (Class 523/112)
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Patent number: 5342693Abstract: The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain.The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas.Type: GrantFiled: March 22, 1993Date of Patent: August 30, 1994Assignee: Cardiopulmonics, Inc.Inventors: Suzanne Winters, Kenneth A. Solen, Clifton G. Sanders, J. D. Mortensen, Gaylord Berry
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Patent number: 5338770Abstract: The present invention is directed to thrombo-resistant coatings for use with gas permeable biomedical devices and implants. The coatings include a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A quantity of at least one bioactive molecule designed to counteract a specific blood-material incompatibility reaction is covalently bonded to the poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain.The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is preferably achieved by plasma etching with ammonia gas.Type: GrantFiled: April 12, 1990Date of Patent: August 16, 1994Assignee: Cardiopulmonics, Inc.Inventors: Suzanne Winters, Kenneth A. Solen, Clifton G. Sanders, JD Mortensen, Gaylord Berry
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Patent number: 5336698Abstract: The invention provides a medical material in which biocompatibility is provided to a substrate stably for over an extended period of time because of the ability of the material to reduce or prevent undesirable physiological properties inherent in the substrate, such as blood clotting, activation of complement system, platelet adhesion and the like. Such abilities are effected by the bonding of a fatty acid and/or its derivative to the substrate through a polymer.Type: GrantFiled: April 27, 1992Date of Patent: August 9, 1994Assignee: Terumo Kabushiki KaishaInventors: Nobuyoshi Kashiwagi, Masatomi Sasaki
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Patent number: 5278200Abstract: Biocompatible heparin-like material and surfaces thereof are made by co-polymerization of acrylic acid (AA) and 2-acrylamido-2-methyl propane sulfonic acid (AMPS) and attaching the copolymer to a suitable substrate or blending the copolymer into a suitable substrate. The material produced also possesses surface slip-properties and some decreased bacterial and platelet adherence.Type: GrantFiled: October 30, 1992Date of Patent: January 11, 1994Assignee: Medtronic, Inc.Inventors: Arthur J. Coury, James R. Keogh, Christopher M. Hobot, Warren W. Howland
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Patent number: 5270046Abstract: Disclosed is an anticoagulant material comprising a polymer obtained from an ionically bonded composite synthesized from i) a basic compound having a copolymerizable functional group and ii) a heparin salt. Disclosed is also a process for preparing the anticoagulant material. The anticoagulant material of the present invention can maintain excellent anticoagulant properties or antithrombotic properties over a long period of time and is capable of being applied as a component material for various medical articles such as artificial internal organs and artificial blood vessels, and a process for preparing it.Type: GrantFiled: November 6, 1991Date of Patent: December 14, 1993Assignee: Ube Industries, Ltd.Inventors: Nagayoshi Sakamoto, Kazutoshi Iida
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Patent number: 5262451Abstract: The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain.The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas.Type: GrantFiled: July 5, 1988Date of Patent: November 16, 1993Assignee: Cardiopulmonics, Inc.Inventors: Suzanne Winters, Kenneth A. Solen, Clifton G. Sanders, J. D. Mortensen, Gaylord Berry
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Patent number: 5244654Abstract: Internal polymeric surfaces of medical devices are provided that have enhanced biocompatibility properties. The internal polymeric surface presents an anti-thrombogenic, fibrinolytic or thrombolytic interface with body fluids such as blood flowing through medical device tubing during implantation for medical procedures. The biocompatibility enhancing agent is secured to the polymeric substrate by a spacer molecule which is covalently bound to the internal polymeric surface which had been subjected to radiofrequency plasma treatment with a low pressure plasma medium of water vapor, oxygen or combination of water vapor and oxygen gas.Type: GrantFiled: June 25, 1991Date of Patent: September 14, 1993Assignee: Cordis CorporationInventor: Pallassana V. Narayanan
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Patent number: 5236592Abstract: A composite material is disclosed that comprises a support membrane coated with an additive that reduces the thrombogenic character of the support. The support membrane is a copolymer of acrylonitrile and at least one ionic or ionizable monomer. The additive is a copolymer of acrylonitrile in which at least one of the comonomers is polyoxyethylene. The composite material of the invention is useful in the treatment of blood, and in particular, dialysis and plasmapheresis.Type: GrantFiled: June 21, 1991Date of Patent: August 17, 1993Assignee: Hospal IndustrieInventors: Philippe Dejardin, Feng Yan, Adrien Schmitt
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Patent number: 5219662Abstract: Polyurethane surfaces are made more biocompatible, particularly with blood, by treatment with a block copolymer of a fluorinated oxazoline and either 2-methyl- or 2-ethyl-2-oxazoline. Such polyurethanes are useful as vascular graft or artificial heart parts.Type: GrantFiled: May 23, 1991Date of Patent: June 15, 1993Assignee: E. I. Du Pont de Nemours and CompanyInventors: Lisa C. Grimminger, Sharon L. Haynie, Mureo Kaku, Dotsevi Y. Sogah
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Patent number: 5182317Abstract: The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The method of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas.Type: GrantFiled: June 17, 1991Date of Patent: January 26, 1993Assignee: Cardiopulmonics, Inc.Inventors: Suzanne Winters, Kenneth A. Solen, Clifton G. Sanders, J. D. Mortensen, Gaylord Berry
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Patent number: 5167960Abstract: Disclosed is a biocompatible, thromboresistant substance useful for implantable and extracorpeoreal devices in contact with the vascular system, and methods for producing the same. The biocompatible, thromboresistant substance comprises a synthetic, biocompatible material, at least one biocompatible base coat layer adhered to at least one surface of the material, and a thrombogenesis inhibitor immobilized on the base coat layer via a component capable of binding the inhibitor. The thrombogenesis inhibitor is hirudin, or an active analog or fragment thereof.Type: GrantFiled: August 3, 1988Date of Patent: December 1, 1992Assignee: New England Deaconess Hospital CorporationInventors: Ralph K. Ito, Frank W. LoGerfo
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Patent number: 5165919Abstract: A medical material comprising a high-molecular weight material and a heparin derivative is provided, which high-molecular weight material comprises a high-molecular weight compound having functional groups capable of binding with epoxy groups, a compound having at least two amino groups and a polymer having a number of epoxy groups, said functional groups and some of said amino groups being bound to said epoxy groups, and which heparin derivative comprises heparin and an epoxy compound having at least two epoxy groups part of which is bound to amino groups in the heparin, the amino groups not bound to the epoxy groups in said high-molecular weight material being bound to the epoxy groups not bound to the amino groups in the heparin derivative. Also provided are an intermediate (high-molecular weight material) to be used for said medical material, as well as processes for producing said medical material and said intermediate.Type: GrantFiled: September 26, 1990Date of Patent: November 24, 1992Assignee: Terumo Kabushiki KaishaInventors: Masatomi Sasaki, Shinichi Kaneda, Nobuyoshi Kashiwagi
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Patent number: 5165952Abstract: An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.Type: GrantFiled: September 21, 1990Date of Patent: November 24, 1992Assignee: Becton, Dickinson and CompanyInventors: Donald D. Solomon, M. Parke Byron
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Patent number: 5153003Abstract: A composition comprising a polymer having dispersed therethrough a prostacyclin derivative selected from the group consisting of compounds of formula (I): ##STR1## (in which R.sup.1 represents hydrogen or lower alkyl, R.sup.2 represents a C.sub.3 -C.sub.12 alkyl group or a C.sub.3 -C.sub.12 alkenyl group; and n is an integer from 1 to 5; and pharmaceutically acceptable salts thereof) can be used to make a medical appliance from which the prostaglandin, having antithrombotic properties, will be released gradually and in a controlled way.Type: GrantFiled: October 18, 1989Date of Patent: October 6, 1992Assignee: Sankyo Company LimitedInventors: Kozo Kurihara, Hironobu Saito, Yukie Misho, Takeshi Oshima
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Patent number: 5134057Abstract: Disclosed is a method of providing a substrate with a layer comprising a polyvinyl base hydrogel and a biochemically active material by photolithograhy, comprising coating the substrate by centrifugal force with an aqueous solution of a photosensitive hydrogel forming polymer, a crosslinking agent and a biochemically active material, drying said coating, exposing the coated substrate through a photomask to ultraviolet radiation and developing said exposed coating, which is characterized by applying to the substrate an aqueous solution comprising as the cross-linking agent a polyazonium compound and glutardialdehyde. Because of this specific combination of cross-linking agents superior properties with respect to the binding of the biochemically active material are obtained.Type: GrantFiled: October 10, 1989Date of Patent: July 28, 1992Assignee: 501 PPG Biomedical Systems, Inc.Inventors: Martinus H. Kuypers, Gerardus F. J. Steeghs, Egbert Brinkmann
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Patent number: 5134192Abstract: A dicarbonyl halide preferably a straight-chain-alkyl dicarbonyl dihalide, may be used to activate a substrate surface of preferably polyurethane or polyamide. Optionally, an amine-end blocked polymer may be reacted with the resulting activated surface by reaction between amine and dicarbonyl halide groups. Then, a material to be covalently bonded to said surface, such as heparin, may be reacted with free amine groups bonded to the surface by a carbodiimide process or the like.Type: GrantFiled: February 14, 1991Date of Patent: July 28, 1992Assignee: Cordis CorporationInventors: Jan Feijen, Gerardus H. M. Engbers
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Patent number: 5126140Abstract: Disclosed is a biocompatible, thromboresistant substance useful for implantable and extracorporeal devices in contact with the vascular system, and methods for producing the same. The biocompatible, thromboresistant substance comprises a synthetic, biocompatible material, at least one biocompatible base coat layer adhered to at least one surface of the material, and the thrombogenesis inhibitor thrombomodulin immobilized on the base coat layer via a component capable of binding the inhibitor without affecting its thrombogenesis-inhibiting activity.Type: GrantFiled: July 24, 1989Date of Patent: June 30, 1992Assignee: New England Deaconess Hospital CorporationInventors: Ralph K. Ito, Frank W. LoGerfo
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Patent number: 5112615Abstract: Disclosed is a soluble, biocompatible, pharmacological agent for inhibiting thrombin generation and thrombus formation, and methods for producing the same. The pharmacological agent or conjugate includes a soluble, biocompatible carrier and a thrombogenesis inhibitor immobilized thereto via the carrier which binds the inhibitor. The thrombogenesis inhibitor is hirudin, or an active analog or active fragment thereof. The thrombogenesis inhibitor may be bound to the carrier via a bifunctional cross-linking reagent.Type: GrantFiled: October 4, 1990Date of Patent: May 12, 1992Assignee: New England Deaconess Hospital CorporationInventors: Ralph K. Ito, Frank W. LoGerfo
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Patent number: 5098977Abstract: Improved articles having reduced thrombogenicity when in contact with blood products containing albumin and methods of their preparation and use are provided. The articles comprise at the surface of blood contact a water insoluble polymeric substrate material having covalently attached thereon aliphatic extension of 12 to 22 carbon atoms. When exposed to blood, the aliphatic chain extensions provide a hydrophobic binding site for albumin. The articles when implemented with whole blood or blood products selectively enhance albumin affinity binding to the exclusion of other blood components, and subsequently minimize thrombus formation as well as other biocompatibility parameters, such as foreign body immune responses.Type: GrantFiled: December 24, 1990Date of Patent: March 24, 1992Assignee: Board of Regents, The University of Texas SystemInventors: Jack Frautschi, Kevin Tingey
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Patent number: 5071973Abstract: The present invention refers to a method concerning the preparation of hemo-compatible substrates by incorporation, adhesion and/or modification and embodiment of non-thrombogenic endothelial cell surface polysaccharide (HS I) in its peptide-bound or free form on and/or mixed with synthetic and biopolymers (Substrates) by way of physical distribution, adhesion to the surface and/or chemical embodiment, which can be used in medicine as blood-compatible substrates. These polymers can be presented in form of fibres, hollow fibres, membranes, organ spare parts, canulas, syringes, tubes, blood containers, or in other forms, or they can be prepared from other material.Type: GrantFiled: September 27, 1990Date of Patent: December 10, 1991Inventors: Ruprecht Keller, Hanno Baumann
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Patent number: 5069899Abstract: Anti-thrombobenic, anti-microbial compositions containing heparin reacted with quaternary ammonium components and bound with water-insoluble polymers are disclosed. Such compositions may also contain additional quaternary ammonium compounds not reacted with heparin and may also contain quaternary ammonium compound(s) reacted with antibiotics.Type: GrantFiled: November 2, 1989Date of Patent: December 3, 1991Assignee: Sterilization Technical Services, Inc.Inventors: Richard J. Whitbourne, Margaret A. Mangan
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Patent number: 5061750Abstract: A substrate for medical devices and a process for making the substrate is provided, the substrate having on at least part of its surface a blood-compatible surface produced by coupling a physiologically active substance to the surface. The physiologically active substance is one having an inhibitory effect on the formation of blood clots and/or is capable of breaking down blood clots formed. The physiologically active substance is bonded to a polyacid, and the polyacid is attached to the surface by a covalent bond.Type: GrantFiled: July 18, 1990Date of Patent: October 29, 1991Assignee: Cordis Europa N.V.Inventors: Jan Feijen, Gerardus H. M. Engbers
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Patent number: 5053453Abstract: Thromboresistant materials are disclosed comprising hirudin or hirudin derivatives covalently linked to support materials such that the resultant composition has substantially the same biological activity as hirudin. Methods for making such compositions are also disclosed.Type: GrantFiled: January 15, 1991Date of Patent: October 1, 1991Assignee: Baxter International Inc.Inventor: Cecilia S. L. Ku
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Patent number: 5053048Abstract: A thromboresistant coating, method for forming same on a medical device, and the medical device thus prepared are provided. The thromboresistant coating is a highly cross-linked three-dimensional matrix copolymerized from an aminosilane component and a silane other than the aminosilane that is cured and dried into a thick matrix having amino groups interspersed therethroughout. The amino groups facilitate attachment of an antithrombogenic agent to the matrix and thus to the medical device. In addition, an antithrombogenic material is secured to the aminosilane copolymeric matrix.Type: GrantFiled: November 8, 1990Date of Patent: October 1, 1991Assignee: Cordis CorporationInventor: Leonard Pinchuk
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Patent number: 5049393Abstract: Disclosed are anti-thrombogenic compositions, methods for their production and products made therefrom. The Anti-thrombogenic compositions comprise a powderized anti-thrombogenic material homogeneously present in a solidifiable matrix material. The anti-thrombogenic material is preferably carbon and more preferably graphite particles. The matrix material is a silicon polymer, a urethane polymer or an acrylic polymer.Type: GrantFiled: June 30, 1988Date of Patent: September 17, 1991Assignee: Baylor College of MedicineInventors: George P. Noon, Louis W. Feldman, Julia A. Peterson
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Patent number: 5019393Abstract: Disclosed is a biocompatible, thromboresistant substance useful for implantable and extracorporeal devices in contact with the vascular system, and methods for producing the same. The biocompatible, thromboresistant substance comprises a synthetic, biocompatible material, at least one biocompatible base coat layer adhered to at least one surface of the material, and a thrombogenesis inhibitor immobilized on the base coat layer via a component capable of binding the inhibitor. The thrombogenesis inhibitor is streptokinase, urokinase, tissue plasminogen activator, ATPase, 5'-nucleotidase, and active fragments and active analogs thereof.Type: GrantFiled: August 3, 1988Date of Patent: May 28, 1991Assignee: New England Deaconess Hospital CorporationInventors: Ralph K. Ito, Frank W. LoGerfo
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Patent number: 5017670Abstract: Improved articles having reduced thrombogenicity when in contact with blood products containing albumin and methods of their preparation and use are provided. The articles comprise at the surface of blood contact a water insoluble polymeric substrate material having covalently attached thereon aliphatic extension of 12 to 22 carbon atoms. When exposed to blood, the aliphatic chain extensions provide a hydrophobic binding site for albumin. The articles when implemented with whole blood or blood products selectively enhance albumin affinity binding to the exclusion of other blood components, and subsequently minimize thrombus formation as well as other biocompatibility parameters, such as foreign body immune responses.Type: GrantFiled: September 23, 1987Date of Patent: May 21, 1991Assignee: Board of Regents, The University of Texas SystemInventors: Jack Frautschi, Kevin Tingey
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Patent number: 5013306Abstract: An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.Type: GrantFiled: March 21, 1990Date of Patent: May 7, 1991Assignee: Becton, Dickinson and CompanyInventors: Donald D. Solomon, M. Parke Byron
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Patent number: 5006259Abstract: Anaphylatoxin adsorbing perfluorinated tetrafluoroethylene copolymer containing acid or selected acid derivative functionality, and process and means for the use thereof.Type: GrantFiled: March 2, 1989Date of Patent: April 9, 1991Assignee: E. I. Du Pont de Nemours and CompanyInventors: Deborah L. Liczwek, Erwin A. Vogler
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Patent number: 4999210Abstract: An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine, an antibiotic, or an antithrombogenic agent permeated into the surface or it may be a polymeric surface layer having bulk distributed chlorhexidine laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine. The article may then be laminated by dipping into a solution of chlorhexidine and a substantially hydrophilic polymer in a solvent.Type: GrantFiled: December 7, 1989Date of Patent: March 12, 1991Assignee: Becton, Dickinson and CompanyInventors: Donald D. Solomon, M. Parke Byron
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Patent number: 4996054Abstract: An antithrombogenic, non-calcifying, and elastic material on a basis of polyurethane, characterized by the addition of fatty-acid esters and optionally by the further addition of cross-linking agents that react with water.Type: GrantFiled: October 19, 1988Date of Patent: February 26, 1991Assignee: Beiersdorf AktiengesellschaftInventors: Hanns Pietsch, Holger Kartheus, Hans-Joachim Holtzmann, Gunther Sachau, Helmut Reul
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Patent number: 4987181Abstract: Copolymer film deposited on a substrate comprising covalently fixed fragments of heparin having antithrombogenic properties. The polymer further comprises free carboxylic groups intended to neutralize free amine functions which are possibly present and to improve the hemocompatibility of the film.Type: GrantFiled: September 19, 1989Date of Patent: January 22, 1991Assignee: Battelle Memorial InstituteInventors: Daniel Bichon, Christian Guillot, Michel Schneider
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Patent number: 4980231Abstract: Processes for treating polymeric surfaces to produce smooth, durable, slippery coatings which are able to withstand the rigors of sterilization and, long term exposure to human blood and other bodily fluids without substantial loss of their slipperiness. An article or device suitable as a wound drainage device coated in accordance with the process described is also disclosed.Type: GrantFiled: February 13, 1989Date of Patent: December 25, 1990Assignee: Snyder Laboratories, Inc.Inventors: John H. Baker, Kim R. Harmon
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Patent number: 4943460Abstract: Processes for treating polymeric surfaces to produce smooth, durable, slippery coatings which are able to withstand the rigors of sterilization and, long term exposure to human blood and other bodily fluids without substantial loss of their slipperiness.Type: GrantFiled: February 13, 1989Date of Patent: July 24, 1990Assignee: Snyder Laboratories, Inc.Inventors: Richard A. Markle, Phyllis L. Brusky, John H. Baker
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Patent number: 4939007Abstract: An article has a blood-contacting hemocompatible surface layer of a urethane-siloxane copolymer on a thermoplastic polymeric base material. The copolymer has siloxane segments prepared from hydroxyalkyl terminated polysiloxane glycols. The article is prepared by coextrusion of the base material and the copolymer.Type: GrantFiled: March 7, 1988Date of Patent: July 3, 1990Assignee: Becton, Dickinson and CompanyInventors: Can B. Hu, Donald D. Solomon, Stanley C. Wells
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Patent number: 4933178Abstract: A medical device with an antimicrobial coating that is safe, effective, photostable and readily manufacturable can be produced by applying a composition to at least one body fluid-contacting surface of the device such that a solid coating is provided on that surface, the coating composition comprising an oligodynamic metal salt of a sulfonylurea, a polymeric material, at least one acid compound selected from the group consisting of a water-soluble carboxylic acid and water-insoluble carboxylic acid, and a carrier liquid in which foregoing components are soluble. The antimicrobial coating accommodates variation in the release of antimicrobial metal ions as a function of the intended use for a medical device to which the coating is applied.Type: GrantFiled: October 7, 1988Date of Patent: June 12, 1990Assignee: Biointerface Technologies, Inc.Inventor: Christopher C. Capelli
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Patent number: 4929510Abstract: A polymer article and a method for making the polymer article. The polymer article includes a hydrophobic polymer substrate and a block copolymer. The block copolymer has at least first and second blocks. The first block is more hydrophobic than the second block. The molecules of the block copolymer are secured into the surface of said substrate by means of the first block and at least a portion of the second block, outwardly extends from the surface of the substrate into the environment.The method for making the polymer article, comprising a block copolymer and a hydrophobic substrate, comprises the steps of: (a) forming a solution of a block copolymer and a solvent which will solubilize said block copolymer and swell said substrate. The block copolymer has at least a first and second block.Type: GrantFiled: April 29, 1988Date of Patent: May 29, 1990Assignee: State University of New YorkInventors: Eli Ruckenstein, Dennis B. Chung
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Patent number: 4925668Abstract: A substantially hydrophilic polymeric medical article has a coating of chlorhexidine and a silicone on its surface and may have chlorhexidine bulk distributed throughout the polymer. The invention includes a method for preparing the article which includes dipping the article into a solution of chlorhexidine and silicone in a solvent. The method may also include preparing a melt of a substantially hydrophilic polymer having bulk distributed chlorhexidine by twin screw compounding a mixture of polymer and chlorhexidine and extruding the melt into the shape of the desired article prior to applying the coating.Type: GrantFiled: January 18, 1989Date of Patent: May 15, 1990Assignee: Becton, Dickinson and CompanyInventors: Mohammad A. Khan, Donald D. Solomon, Matthew P. Byron
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Patent number: 4882148Abstract: Implantable devices for medical use are provided which have been subjected to treatment with a crack preventative/antithrombogenic agent in the form of a sulfate. This treatment substantially prevents surface cracking or fissuring of the subcutaneous implantation as well as preventing thrombus formation along the blood contacting surfaces of the treated material.Type: GrantFiled: June 18, 1987Date of Patent: November 21, 1989Assignee: Corvita CorporationInventor: Leonard Pinchuk
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Patent number: 4865870Abstract: A method for heparinizing a substrate includes applying a coating of ammonium salt to a substrate by steeping the substrate in a solution of the salt at an alkaline pH and contacting the coated substrate with a solution of a salt of heparin.Type: GrantFiled: July 7, 1988Date of Patent: September 12, 1989Assignee: Becton, Dickinson and CompanyInventors: Can B. Hu, Donald D. Solomon, Nancy L. Shields
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Patent number: 4861830Abstract: A polymer admixture is formed from a base polymer and thermoplastic copolymer additive including polar hard segments and polar and nonpolar soft blocks in graft or block copolymer form. The polymer admixture is characterized by increased contact angle hysteresis and is formed into blood and tissue-contacting surfaces of a biomedical device or into textiles. A preferred additive comprises a segmented block copolymer having polydialkylsiloxanes as nonpolar soft blocks, and a polyurethane as hard segments and a polyalkylene oxide as a polar soft block.Type: GrantFiled: June 22, 1987Date of Patent: August 29, 1989Assignee: Th. Goldschmidt AGInventor: Robert S. Ward, Jr.
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Patent number: 4833200Abstract: An antithrombogenic medical material with a remarkable antithrombogenic property and histocompatibility as well as sufficient physical strength, formed by fixing a heparinized collagen to a synthetic polymer material is provided. And a method of preparing an antithrombogenic medical material is provided, wherein a synthetic polymer material is subjected to a coating or impregnating treatment with a collagen-containing solution, followed by heparinization of the collagen, and the heparinized collagen is fixed to the synthetic polymer material. This method allows manufacturing of antithrombogenic medical material with ease.Type: GrantFiled: July 25, 1986Date of Patent: May 23, 1989Assignee: Koken Co., Ltd.Inventors: Yasuharu Noishiki, Teruo Miyata
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Patent number: 4831065Abstract: An antithrombogenic, non-calcifying, and elastic material on a basis of polyurethane, characterized by the addition of fatty-acid esters and optionally by the further addition of cross-linking agent that react with water.Type: GrantFiled: November 20, 1986Date of Patent: May 16, 1989Assignee: Beiersdorf AktiengesellschaftInventors: Hanns Pietsch, Holger Kartheus, Hans-Joachim Holtzmann, Gunther Sachau, Helmut Reul
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Patent number: 4806595Abstract: In a method of preparing an antithrombogenic medical material having a heparinized collagen as an antithrombogenic component, there is provided a method comprising the steps of fixing a protamine to a collagen through a polyepoxy compound, and heparinizing the collagen by fixing heparin to the protamine.Type: GrantFiled: August 1, 1986Date of Patent: February 21, 1989Assignee: Koken Co., Ltd.Inventors: Yasuharu Noishiki, Kazuhiko Kodaira, Masayasu Furuse, Teruo Miyata
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Patent number: 4792599Abstract: A biocompatible polyester comprising repeating units derived from glycerophosphorylcholine or glycerophosphorylethanolamine and at least one di- or poly-functional acid or reactive derivative thereof is haemocompatible and may be used in components for handling body fluids and in prostheses.Type: GrantFiled: March 3, 1988Date of Patent: December 20, 1988Assignee: Biocompatibles Ltd.Inventor: Aziz A. Durrani
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Patent number: 4786556Abstract: Plastic articles having enhanced antithrombogenic activity due to the presence or hydrophobic materials attached to amine compounds bonded on the surface of the plastic which repel bonded antithrombogenic agents outwardly from the plastic surface, making them more readily available to the blood for subsequent thrombus inhibition.Type: GrantFiled: July 24, 1987Date of Patent: November 22, 1988Assignee: Becton, Dickinson and CompanyInventors: Can B. Hu, Donald D. Solomon
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Patent number: 4725279Abstract: Bio-and blood compatible materials are prepared by treating the surface of a substrate to provide reactive primary or secondary amine groups sites which are activated by treatment with a dialdehyde or arylchloride for coupling to a biological in an amount sufficient to provide compatibility. The use of specific substrates, such as a compliant, and elastic material, such as a fabric-elastomer membrane matrix, results in a product having advantageous qualities as a thermal burn dressing. Detailed procedures and various products are described including gloves and sleeves and tubes with or without adhesive to facilitate formation of sheet materials into various forms and products. The products may have small holes provided therein for the rapid passage of accumulated fluid away from the wound or infusion of liquid materials to the wound site.Type: GrantFiled: May 28, 1985Date of Patent: February 16, 1988Assignee: Sterling Drug Inc.Inventor: E. Aubrey Woodroof
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Patent number: 4720512Abstract: Plastic articles having enhanced antithrombogenic activity due to the presence of hydrophobic materials attached to amine compounds bonded on the surface of the plastic which repel bonded antithrom bogenic agents outwardly from the plastic surface, making them more readily available to the blood for subsequent thrombus inhibition.Type: GrantFiled: March 24, 1986Date of Patent: January 19, 1988Assignee: Becton, Dickinson and CompanyInventors: Can B. Hu, Donald D. Solomon
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Patent number: 4713402Abstract: An antithrombogenic/antibiotic plastic material prepared using an organic solvent system containing a specific chlorofluorocarbon compound and petroleum ether.Type: GrantFiled: August 30, 1985Date of Patent: December 15, 1987Assignee: Becton, Dickinson and CompanyInventor: Donald D. Solomon
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Patent number: 4678660Abstract: An antithrombogenic thermoplastic polyurethane product and process for preparing the same which comprises a substrate and at least one layer of a polyurethane alloy complex comprising a thermoplastic polyurethane and completely dispersed therein a preformed complex of an antithrombogenic material ionically bonded with a quaternary ammonium compound.Type: GrantFiled: August 14, 1985Date of Patent: July 7, 1987Assignee: Deseret Medical, Inc.Inventors: Charles W. McGary, Donald D. Solomon