Unsaturated Carboxylic Acid Or Derivative Reactant Patents (Class 527/314)
  • Patent number: 9193810
    Abstract: A process is described comprising polymerizing at least one unsaturated monomer (e.g., fluorine substituted alkene monomer) in the presence of a hypervalent iodide radical initiator and a solvent, under reaction conditions and for a time sufficient to polymerize the at least one unsaturated monomer to form a polymer. The present disclosure provides a method for living polymerization of unsaturated monomers (e.g., fluorine substituted alkene monomers), which provides a high level of macromolecular control over the polymerization process and which leads to uniform and controllable polymeric products. The present disclosure also provides a method of functionalization of organic substrates with a CF3 or perfluoro (RF) group.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: November 24, 2015
    Assignee: UNIVERSITY OF CONNECTICUT
    Inventor: Alexandru D. Asandei
  • Patent number: 9012415
    Abstract: This invention refers to photo-crosslinked hydrogel materials based in gellan gum suitable for tissue engineering and regenerative medicine applications or as drug delivery systems. Formulations of gellan gum with different degrees of acylation serve as precursor material for insertion of a polymerizable moiety. The materials are capable of free radical polymerization with a photo-initiator at mild temperatures and exposure to ultraviolet light, enabling control of reticulation and withstanding the encapsulation of human and animal cells and/or drugs, and any combination thereof. The physicochemical and biological properties can be adjusted by combining different formulations of gellan gum and reaction conditions.
    Type: Grant
    Filed: March 26, 2011
    Date of Patent: April 21, 2015
    Assignee: Stemmatters, Biotecnologia e Medicina Regenerativa S.A.
    Inventors: Joana Catarina Da Silva Correia, Joaquim Miguel Antunes De Oliveira, João Manuel Teixeira De Oliveira, Rui Pedro Amandi Romero De Sousa, Rui Luis Gonçalves Dos Reis
  • Publication number: 20140350188
    Abstract: Nanocrystalline cellulose (NCC)-based supramolecular materials, a method for their preparation and their use in thermoplastic and thermoset polymer composites are disclosed. Supramolecular materials of NCC and one or two polymers are synthesized by in situ surface graft copohmerization in a multitude of solvent systems, including water. The nano-scale size supramolecular materials are engineered to have a unique combination of lowr polarity and high hydrophobicity and function as copohmers for demanding pohmeric systems such as, but not limited to, polyolefins and polyesters. Nanocomposite materials of enhanced functionality and mechanical properties are produced by compounding the NCC-based supramolecular materials with polymer matrices. The supramolecular materials are used in composite development for packaging materials, structural composites for automotive and construction, as sandwiched foam composites or, combined with biocompatible polymers, in medical applications.
    Type: Application
    Filed: September 12, 2012
    Publication date: November 27, 2014
    Applicant: Celluforce Inc.
    Inventors: Wadood Y. Hamad, Shunxing Su
  • Publication number: 20140271601
    Abstract: Methods of controlled delivery of bioactive therapeutics are provided. Compositions comprising therapeutic implants are provided.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: InVivo Therapeutics Corporation
    Inventors: Alex A. Aimetti, Timothy M. O'Shea, Robert S. Langer, Xueqing Zhang
  • Publication number: 20140182064
    Abstract: A graft polymer of polysaccharides or polypeptides or its respective derivatives, obtainable by free radical polymerization of A) a monomer selected from or a monomer mixture of (a) from 20 to 100% by weight of acrylic acid or methacrylic acid or of a mixture thereof or of the alkali metal, alkaline earth metal or ammonium salts thereof, (b) from 0 to 80% by weight of other monoethylenically unsaturated monomers which are copolymerizable with the monomers (a) and (c) from 0 to 5% by weight of monomers having at least 2 ethylenically unsaturated, nonconjugated double bonds in the molecule, in the presence of either B1) polysaccharides, oxidatively, hydrolytically or enzymatically degraded polysaccharides, oxidized hydrolytically degraded or oxidized enzymatically degraded polysaccharides, or such chemically modified degraded products, chemically modified mono-, oligo-or poly-saccharides or mixtures of the stated compounds and/or B2) polypeptides, their hydrolysates or enzymaticallydegraded and optionally chemi
    Type: Application
    Filed: May 25, 2012
    Publication date: July 3, 2014
    Applicant: LANXESS DEUTSCHLAND GMBH
    Inventor: Ma Song
  • Patent number: 8613834
    Abstract: A paper coating or binding formulation comprises an aqueous polymer dispersion comprising a copolymer obtained by polymerization of an unsaturated monomer and a carbohydrate derived compound and a tetrasulfonate-based fluorescent whitening agent. The carbohydrate derived compound can be selected from the group consisting of dextrins, maltodextrins, and mixtures thereof. Methods of preparing a paper coating or binding formulation and improving the whitening properties of paper are also provided. Furthermore, paper including a copolymer obtained by polymerization of an unsaturated monomer and a carbohydrate derived compound and a tetrasulfonate-based fluorescent whitening agent is also disclosed.
    Type: Grant
    Filed: April 3, 2008
    Date of Patent: December 24, 2013
    Assignee: BASF SE
    Inventors: Peter C. Hayes, Ralph Lewis De Jong
  • Publication number: 20130289136
    Abstract: A glucan biopolymer obtained from Manihot esculenta as a cosmetic active principle for instant skin tightening, and a cosmetic skincare method using the same. Also, a specific active principle provided in the form of a glucan polymer obtained from Manihot esculenta, the method for obtaining the active principle and the cosmetic compositions including same.
    Type: Application
    Filed: December 23, 2011
    Publication date: October 31, 2013
    Applicant: SOCIETE INDUSTRIELLE LIMOUSINE D'APPLICATION BIOLOGIQUE
    Inventor: Jean Paufique
  • Patent number: 8557125
    Abstract: A coagulant composition includes chitosan, methacryloyloxyethyltrimethyl ammonium methyl sulfate and a redox initiator. A coagulant, method for making the coagulant and clarifying wastewater is also provided.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: October 15, 2013
    Assignee: General Electric Company
    Inventors: Seethalakshmi Suresh, Stephen Robert Vasconcellos, Narain Madhavan, Baraka Kawawa
  • Patent number: 8497319
    Abstract: The present invention relates to a dispersion comprising an acryl-modified cellulose ester derivative (D) dispersed in an aqueous medium, wherein a hydrophobic acrylic resin (B) and a hydrophilic acrylic resin (C) are grafted onto a cellulose ester derivative (A) in the acryl-modified cellulose ester derivative (D). The dispersion has excellent long-term storage stability, and aqueous coating compositions comprising the dispersion can form coating films with excellent coating workability, solvent resistance, chemical resistance, water resistance, and excellent curability.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: July 30, 2013
    Assignee: Kansai Paint Co., Ltd.
    Inventors: Chikara Kawamura, Kisheong Han
  • Publication number: 20130171026
    Abstract: A modified porous membrane comprising a polymer coating grafted to a porous membrane is described. The polymer coatings grafted to the porous membranes generally comprise a polymer of variable length of an electron beam (e-beam) reactive moiety, designated “poly-(A)x,” a linkage group that forms a bond between the between the poly-(A)x, and a functional B group available to react with a chemical group on a biomolecule, wherein the polymer coating on the porous membrane facilitates the immobilization of a biomolecule, such as DNA, RNA, a protein, and an antibody, on the porous membrane. The compositions find use in immunoassays, in vitro diagnostic tests, point of care tests, techniques for the isolation of a biomolecule from a biological sample, and other methods that require the immobilization of a biomolecule on a porous membrane. Methods of making these modified porous membranes are also disclosed.
    Type: Application
    Filed: December 29, 2011
    Publication date: July 4, 2013
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Bing Li, Cathryn Ellen Olsen, David Roger Moore
  • Publication number: 20130137799
    Abstract: Anionic graft copolymers and scale inhibition compositions including the anionic graft copolymers in which the anionic graft copolymers include a natural component grafted with an ethylenically unsaturated anionic monomer where the anionic graft copolymer includes 1 or more reacted anhydroglucose units per every 100 anhydroglucose units in the anionic graft copolymer.
    Type: Application
    Filed: July 30, 2010
    Publication date: May 30, 2013
    Applicant: AKZO NOBEL N.V.
    Inventors: Klein A. Rodrigues, Matthew M. Vanderhoof, John Ozbek
  • Publication number: 20130112623
    Abstract: The invention describes a composite microfiber, which is comprising a polysaccharide polymer selected from the group consisting of cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, n-propyl cellulose, isopropyl cellulose, cellulose acetate and combinations of two or more of these substances, and combinations of two or more of these substances, thereby the polysaccharide polymer further comprising substituents comprising a given formula, wherein k is 1 or greater, and wherein each moiety R1 is independently selected from H and methyl, and wherein each moiety R2 is independently selected from —H, —OH, —NH2, —SH, —OR3, —NHR3 and —NR3R4, —SR3, and wherein each moiety R3 and R4 are chemical groups independently selected from C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkoxy halide and C1-C4 heteroalkyl substituents, and is preferably selected from —CH3, —CH2—CH3, —CH2—OH, —CH2—CH2—OH, —CH2—CH2—NH2, —CH—CH(OH)—CH2—OH, —CH—CH(OH)—CH3, glycidyl, anhydride, sulfonic acid and hydroxys
    Type: Application
    Filed: November 20, 2012
    Publication date: May 9, 2013
    Applicant: JACOBS UNIVERSITY BREMEN GGMBH
    Inventors: MARCELLO FERNANDEZ-LAHORE, MARIANO GRASSELLI
  • Patent number: 8404662
    Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: March 26, 2013
    Assignees: Cerulean Pharma Inc., Insert Therapeutics, Inc., Calando Pharmaceuticals, Inc.
    Inventors: Jianjun Cheng, Mark Davis, Kay T. Khin
  • Patent number: 8399431
    Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: March 19, 2013
    Assignees: Cerulean Pharma Inc., Insert Therapeutics, Inc., Calando Pharmaceuticals, Inc.
    Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
  • Patent number: 8372933
    Abstract: Hyperbranched, water-soluble polymers, obtainable by Michael polyaddition of ?-, ?-, or ?-cyclodextrins and amines to bisacrylamides.
    Type: Grant
    Filed: June 10, 2008
    Date of Patent: February 12, 2013
    Assignee: L'Urederra Fundacion Para el Desarrollo Tecnologico y Social
    Inventors: Paolo Ferruti, Elisabetta Ranucci, Francesco Trotta, Roberta Cavalli, Claudio Fernandez
  • Publication number: 20130017177
    Abstract: This invention refers to photo-crosslinked hydrogel materials based in gellan gum suitable for tissue engineering and regenerative medicine applications or as drug delivery systems. Formulations of gellan gum with different degrees of acylation serve as precursor material for insertion of a polymerizable moiety. The materials are capable of free radical polymerization with a photo-initiator at mild temperatures and exposure to ultraviolet light, enabling control of reticulation and withstanding the encapsulation of human and animal cells and/or drugs, and any combination thereof. The physicochemical and biological properties can be adjusted by combining different formulations of gellan gum and reaction conditions.
    Type: Application
    Filed: March 26, 2011
    Publication date: January 17, 2013
    Inventors: Joana Catarina Da Silva Correia, Joaquin Miguel Antunes De Oliveira, Joâo Manuel Teixeira De Oliveira, Rui Pedro Amandi Romero De Sousa, Ruiç Luis Gonçalves Dos Reis
  • Patent number: 8354368
    Abstract: Disclosed is the use of water-soluble graft copolymers prepared by free-radically initiated graft polymerization of 40 to 90% by weight of component (A), selected from the group consisting of monosaccharides, oligosaccharides, polysaccharides and derivatives thereof, with 5 to 40% by weight of monomers (B), selected from the group consisting of ethylenically unsaturated C3-C10 monocarboxylic acids or the alkali or ammonium salts thereof, and 10 to 50% by weight of monomers (C), selected from the group consisting of ethylenically unsaturated N-containing monomers and/or ethylenically unsaturated monomers containing sulfo-groups, in cleaning compositions which, as well as the graft polymer, comprise at least one surfactant component, for hydrophilization and/or improvement of shine retention of hard surfaces which have been brought into contact with these cleaning compositions.
    Type: Grant
    Filed: June 12, 2009
    Date of Patent: January 15, 2013
    Assignee: Cognis IP Management GmbH
    Inventors: Christoph Schunicht, Thomas Albers, Ute Lemke, Michael Langen, Rainer Eskuchen
  • Patent number: 8349948
    Abstract: A green approach for the development of nanocomposite materials comprising nanocrystalline cellulose (NCC) and appropriate vinyl polymers is conceived. The approach deals with the in-situ graft co-polymerization of hydrophobic vinyl monomers, such as vinyl acetate and methyl methacrylate, onto the NCC surface in an aqueous medium. The resulting material is significantly more hydrophobic and thermally stable than the starting NCC. The nanocomposite material can be suspended in appropriate solvents, dried and molded with other materials using conventional polymer processing techniques to develop yet new materials with new characteristics. These nanocomposites have wide ranging applications from industrial to medical use.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: January 8, 2013
    Assignee: FPInnovations
    Inventors: Wadood Y. Hamad, Shunxing Su
  • Publication number: 20120264904
    Abstract: An apparatus and method for manufacturing a deodorizing yarn where a cellulose-based yarn is treated with a deodorizing solution by a graft polymerization reaction using steam heat in a reactor that is used in a conventional dyeing apparatus. The method for manufacturing the deodorizing yarn comprises the steps of: mixing a polymerization initiator, a deodorizing monomer and water to prepare a deodorizing solution; allowing the deodorizing solution to penetrate into bobbins, wound with a cellulose-based yarn, in a reactor; discharging the deodorizing solution from a reactor and dewatering the deodorizing solution that penetrated into the bobbins; supplying steam to the inside of the reactor so as to subject the cellulose-based yarn to thermal graft polymerization; water-washing the cellulose-based yarn that was subjected to the thermal graft polymerization; and drying the washed cellulose-based yarn at high temperature.
    Type: Application
    Filed: April 28, 2011
    Publication date: October 18, 2012
    Inventor: Tae Kyung KIM
  • Patent number: 8278374
    Abstract: Embodiments of the present disclosure provide for processes for manufacture of a dry strength paper, methods for imparting dry strength to paper using a cationic starch graft polymer, and the like.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: October 2, 2012
    Assignee: Kemira Oyj
    Inventors: Bernd Hauschel, Bernd Thiele, Thomas Hubbe, Bernhard Jansen
  • Publication number: 20120190726
    Abstract: Embodiments of the invention include functionalized polysaccharides and compositions and structures including the same. In an embodiment, the invention includes an active agent delivery composition including a polysaccharide functionalized with a coupling group, wherein the polysaccharide lacks charged groups at a pH of between 6 and 8; and a complex comprising a nucleic acid and a transfection agent. In an embodiment, the invention includes an active agent delivery structure including a matrix comprising a polysaccharide covalently cross-linked through the residue of a coupling group on the polysaccharide, the polysaccharide lacking charged groups at a pH of between 6 and 8; and a nucleic acid delivery complex disposed within the active agent delivery structure. In an embodiment, the invention includes a material for medical applications including glycogen functionalized with coupling groups at a degree of substitution of between about 0.01 and 0.5. Other embodiments are also included herein.
    Type: Application
    Filed: December 22, 2011
    Publication date: July 26, 2012
    Inventor: Joram Slager
  • Publication number: 20120136131
    Abstract: Provided is a method of living radical polymerization which does not necessitate complicated and intricate synthesis of a dormant species and which is highly efficient. A halogenated derivative compound is used as a dormant species for initiating living radical polymerization. The derivative compound is obtained by halogenating an alcohol compound having a non-conjugated structure or an amine compound having a non-conjugated structure with a halogenating agent capable of halogenating an alcohol or amine. A radical produced by elimination of halogen from the halogenated derivative compound is allowed to react with the unsaturated bond of the monomer. Thus, the monomer, which has a radical-reactive unsaturated bond, is polymerized by living radical polymerization. Preferably, the halogenating agent is a compound (NIS or the like) which also has a function as a catalyst.
    Type: Application
    Filed: June 3, 2010
    Publication date: May 31, 2012
    Applicant: KYOTO UNIVERSITY
    Inventors: Atsushi Goto, Jeong Sik Kim, Yoshinobu Tsujii, Takeshi Fukuda
  • Publication number: 20120114615
    Abstract: Provided are polysaccharide compositions capable of controllable hydrolytic degradation and suitable for controlled release of therapeutic agents. Also provided are methods for synthesizing such compositions and a variety of applications in which the compositions may be used.
    Type: Application
    Filed: December 8, 2009
    Publication date: May 10, 2012
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Jason Alan Burdick, Sujata Sahoo, Cindy Chung
  • Publication number: 20110303611
    Abstract: Disclosed is a cross-linked molecularly imprinted polymer including cross-linked chitosan having selective binding sites for phosphate ions, phosphate containing molecules, or a combination of both.
    Type: Application
    Filed: June 3, 2011
    Publication date: December 15, 2011
    Inventors: Tracy J. Terry, Andrew F. Mason, Carl A. Marrese
  • Publication number: 20110297622
    Abstract: A coagulant composition includes chitosan, methacryloyloxyethyltrimethyl ammonium methyl sulfate and a redox initiator. A coagulant, method for making the coagulant and clarifying wastewater is also provided.
    Type: Application
    Filed: June 7, 2010
    Publication date: December 8, 2011
    Inventors: Seethalakshmi SURESH, Stephen Robert Vasconcellos, Narain Madhavan, Baraka Kawawa
  • Patent number: 8003079
    Abstract: Nanoparticles having an average particle size of less than 2000 nm, wherein said nanoparticles comprise a polymer having pendant cleavable iodine substituted groups are provided. Processes for preparing the nanoparticles and their use as a contrast agent for X-ray imaging are also described.
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: August 23, 2011
    Assignee: Bar-Ilan University
    Inventors: Shlomo Margel, Anna Galperin
  • Publication number: 20110201755
    Abstract: A green approach for the development of nanocomposite materials comprising nanocrystalline cellulose (NCC) and appropriate vinyl polymers is conceived. The approach deals with the in-situ graft co-polymerization of hydrophobic vinyl monomers, such as vinyl acetate and methyl methacrylate, onto the NCC surface in an aqueous medium. The resulting material is significantly more hydrophobic and thermally stable than the starting NCC. The nanocomposite material can be suspended in appropriate solvents, dried and moulded with other materials using conventional polymer processing techniques to develop yet new materials with new characteristics. These nanocomposites have wide ranging applications from industrial to medical use.
    Type: Application
    Filed: February 1, 2011
    Publication date: August 18, 2011
    Applicant: FPINNOVATIONS
    Inventors: Wadood Y. HAMAD, Shunxing SU
  • Publication number: 20110118168
    Abstract: Disclosed is the use of water-soluble graft copolymers prepared by free-radically initiated graft polymerization of 40 to 90% by weight of component (A), selected from the group consisting of monosaccharides, oligosaccaharides, polysaccharides and derivatives thereof, with 5 to 40% by weight of monomers (B), selected from the group consisting of ethylenically unsaturated C3-C10 monocarboxylic acids or the alkali or ammonium salts thereof, and 10 to 50% by weight of monomers (C), selected from the group consisting of ethylenically unsaturated N-containing monomers and/or ethylenically unsaturated monomers containing sulfo-groups, in cleaning compositions which, as well as the graft polymer, comprise at least one surfactant component, for hydrophilization and/or improvement of shine retention of hard surfaces which have been brought into contact with these cleaning compositions.
    Type: Application
    Filed: June 12, 2009
    Publication date: May 19, 2011
    Applicant: COGNIS IP MANAGEMENT GMBH
    Inventors: Christoph Schunicht, Thomas Albers, Ute Lemke, Michael Langen, Rainer Eskuchen
  • Patent number: 7915340
    Abstract: A cationic starch graft copolymer is prepared by polymerization of monomers a) to d) a) 20-80% by weight of acrylamide, methacrylamide or mixtures thereof, b) 3-20% by weight of at least one basic or cationic vinyl monomer; c) 0.005-1.5% by weight of at least one bifunctional or higher-functional crosslinking agent, d) 0-10% by weight of at least one nonionic or anionic vinyl monomer which differs from the monomers mentioned under a) to c) in the presence of a grafting base e) e) 15˜70% by weight of at least one starch or one starch derivative, the sum of a) to e) being 100% by weight.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: March 29, 2011
    Inventors: Bernd Hauschel, Bernd Thiele, Thomas Hübbe, Bernhard Jansen
  • Patent number: 7910680
    Abstract: The present invention relates to new (meth)acrylate compositions, their preparation and their use in ultraviolet light curable applications such as coatings, inks and adhesives.
    Type: Grant
    Filed: April 25, 2007
    Date of Patent: March 22, 2011
    Assignee: Dow Global Technologies LLC
    Inventors: Jerry E. White, Jim D. Earls, Peter S. Martin, Mike B. McIntosh, Richard M. Wehmeyer
  • Publication number: 20110021734
    Abstract: Film forming polymers derived substantially from biorenewable polysaccharides may be formed as the emulsion polymerization products of a blend of hydrophobic polysaccharides and ethylenically unsaturated monomers. The hydrophobic polysaccharides may be prepared as the emulsion reaction product of a water soluble polysaccharide and a monomer mixture of hydrophilic ethylenically unsaturated monomers and hydrophobic ethylenically unsaturated monomer, in the presence of a water soluble chain transfer agent.
    Type: Application
    Filed: July 14, 2010
    Publication date: January 27, 2011
    Applicant: THE SHERWIN-WILLIAMS COMPANY
    Inventors: Gamini S. Samaranayake, Richard F. Tomko, Philip J. Ruhoff, Madhukar Rao
  • Patent number: 7786238
    Abstract: Cationic starch graft copolymer composed of the monomers a) to d) a) 20-80% by weight of acrylamide, methacrylamide or mixtures thereof, b) 3-20% by weight of at least one basic or cationic vinyl monomer, c) 0.005-1.5% by weight of at least one bifunctional or higher-functional crosslinking agent, d) 0-10% by weight of at least one nonionic or anionic vinyl monomer which differs from the monomers mentioned under a) to c) and a grafting base e) e) 15-70% by weight of at least one starch or one starch derivative, the sum of a) to e) being 100% by weight.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: August 31, 2010
    Assignee: Kemira Oyj
    Inventors: Bernd Hauschel, Bernd Thiele, Thomas Hübbe, Bernhard Jansen
  • Publication number: 20100166695
    Abstract: Designed herein are multivalent heterobifunctional polymers for binding to a biological target exhibiting biological activity and to an effector template which can affect the biological activity of the biological target or detect the presence of the biological target. The polymers comprise a plurality of pre-arranged heterobifunctional ligands connected thereto, and each heterobifunctional ligand comprises a first functionality capable of binding to the biological target, and a second functionality capable of binding to the effector template. The heterobifunctional ligands are pre-arranged on the polymer so as to form a ternary complex between the polymer, the biological target and the effector template. The polymers, methods and compositions described herein provide an approach for the design and production of new therapeutic agents as well as agents useful in a variety of non-therapeutic applications.
    Type: Application
    Filed: March 20, 2008
    Publication date: July 1, 2010
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: David R. Bundle, Pavel kitov
  • Patent number: 7718761
    Abstract: An aspect of the invention provides a heat treatment method of a thermoplastic resin film comprising running a strip shaped thermoplastic resin film in a longitudinal direction and heating the thermoplastic resin film while holding the edge of the film in a width direction to conduct a heat treatment, wherein a tension of the thermoplastic resin film in the width direction is controlled to be constant. According to the aspect of the invention, since a thermoplastic resin film during a heat treatment is held with a constant tension in a width direction, the thermoplastic resin film during the heat treatment can be prevented from sagging or pulling excessively. Therefore, occurrence of variability of optical characteristics can be prevented, and thus a thermoplastic resin film excellent in optical characteristics can be produced.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: May 18, 2010
    Assignee: FUJIFILM Corporation
    Inventor: Tetsuya Yoshida
  • Patent number: 7674839
    Abstract: The invention relates to methods for the production of polymer carrier materials for solid phase synthesis, particularly for peptide synthesis. (Meth)acrylamide derivatives based on carbon hydrates, which can also contain other protective groups, are polymerized by means of suspension polymerization in an aqueous phase, optionally with the addition of pore-forming additives, and subsequently the protective groups are fully or partially cleaved. It is thus possible to obtain polymer carriers whose morphology (particle size, porosity), degree of cross-linking and swelling capability in aqueous and organic media can be adjusted in a targeted manner and whose reactive groups offer multiple opportunities for the immobilization of anchor groups and protective groups. The hydroxyl groups of the polymer carrier can be activated according to usual methods of solid phase synthesis.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: March 9, 2010
    Assignee: Technische Universitat
    Inventors: Thomas Verdianz, Heinrich Gruber, Simone Knaus, Alexander Poschalko
  • Publication number: 20100041850
    Abstract: A composition comprising a highly esterified polyol polyester wherein the polyester comprises a polyol residue and a plurality of fatty acids esters, and wherein from about 5% to about 80% of the fatty acid esters contains two or more pairs of conjugated double bonds.
    Type: Application
    Filed: August 7, 2009
    Publication date: February 18, 2010
    Inventors: Roger Stephen Berger, Deborah Jean Back
  • Publication number: 20100041849
    Abstract: A composition comprising a highly esterified polyol polyester wherein the polyester comprises a polyol residue and a plurality of fatty acids esters, and wherein from about 5% to about 80% of the fatty acid esters contains exactly one pair of conjugated double bonds.
    Type: Application
    Filed: August 7, 2009
    Publication date: February 18, 2010
    Inventors: Roger Stephen Berger, Deborah Jean Back
  • Publication number: 20090311192
    Abstract: Nanoparticles having an average particle size of less than 2000 nm, wherein said nanoparticles comprise a polymer having pendant cleavable iodine substituted groups are provided. Processes for preparing the nanoparticles and their use as a contrast agent for X-ray imaging are also described.
    Type: Application
    Filed: April 4, 2006
    Publication date: December 17, 2009
    Applicant: Bar-Ilan University
    Inventors: Shlomo Margel, Anna Galperin
  • Publication number: 20090136736
    Abstract: A water-absorbent resin is provided which is suitable for absorbing polymer-containing viscous liquids, wherein the specific surface area measured by the BET multipoint technique using krypton gas as the adsorption gas is no less than 0.05 m2/g, and the water retention capacity for 0.9 wt % physiological saline is 5-30 g/g.
    Type: Application
    Filed: January 15, 2009
    Publication date: May 28, 2009
    Applicant: Sumitomo Seika Chemicals Co., Ltd.
    Inventors: YASUHIRO NAWATA, Masakazu Yamamori, Koji Ueda, Hideki Yokoyama, Masato Fujikake
  • Publication number: 20080269451
    Abstract: The present invention is concerned with providing antimicrobial compounds and processes for the production thereof. More particularly, the present invention provides antimicrobial polymeric materials comprising a polymer linked to a positively charged moiety via a carboxyl group. The present invention also provides processes for the production of such antimicrobial compounds and uses therefor.
    Type: Application
    Filed: August 12, 2004
    Publication date: October 30, 2008
    Applicant: ETHICON, INC.
    Inventors: Robert Engel, JaimeLee I. Rizzo, Karin Melkonian, Paul Watt
  • Publication number: 20080242824
    Abstract: An aspect of the invention provides a heat treatment method of a thermoplastic resin film comprising running a strip shaped thermoplastic resin film in a longitudinal direction and heating the thermoplastic resin film while holding the edge of the film in a width direction to conduct a heat treatment, wherein a tension of the thermoplastic resin film in the width direction is controlled to be constant. According to the aspect of the invention, since a thermoplastic resin film during a heat treatment is held with a constant tension in a width direction, the thermoplastic resin film during the heat treatment can be prevented from sagging or pulling excessively. Therefore, occurrence of variability of optical characteristics can be prevented, and thus a thermoplastic resin film excellent in optical characteristics can be produced.
    Type: Application
    Filed: March 28, 2008
    Publication date: October 2, 2008
    Applicant: FUJIFILM Corporation
    Inventor: Tetsuya Yoshida
  • Publication number: 20080131512
    Abstract: A prepolymer comprises polymerisable macromolecules, each polymerisable macromolecule comprises a polysaccharide backbone and at least two side units, wherein each of the at least two side units comprises a polymerisable group which is connected to the backbone via at least one group which is hydrolysable under physiological conditions; wherein the polymerisable group of each of the side units is independently selected from optionally alkylated and/or hydroxyalkylated acrylates and acrylamides; and wherein the at least one group which is hydrolysable under physiological conditions is selected from carbonate, lactate, glycolate, and succinate. The invention is also directed to biodegradable hydrogels useful in pharmaceutical compositions, comprising polymerized or co-polymerized prepolymers.
    Type: Application
    Filed: December 28, 2004
    Publication date: June 5, 2008
    Inventors: Wilhelmus Everhardus Hennink, Wendelmoed Nelletha Eleonora Van Dijk-Wolthuis
  • Publication number: 20080119808
    Abstract: Water-absorbent resin particles, characterized in that the water-absorbent resin particles have a water-retention capacity of physiological saline (X) of from 30 to 70 g/g, that the water-retention capacity of physiological saline (X) and a water absorption index under pressure (Y) satisfy the relationship of the formula: [Water absorption index under pressure (Y)]?150 ?2[Water-retention capacity of physiological saline (X)], and that the water-absorbent resin particles have a liquid-suction rate from pulp of 20 g/g/5 minutes or more; and an absorbent material and an absorbent article, each in which the water-absorbent resin particles are used. The absorbent material in which the water-absorbent resin particles are used can be suitably used, for example, in absorbent articles such as disposable diapers and sanitary napkins.
    Type: Application
    Filed: November 11, 2005
    Publication date: May 22, 2008
    Inventors: Masayoshi Handa, Yasuhiro Nawata
  • Publication number: 20080108772
    Abstract: The present invention discloses a method for producing a reinforced organic polymeric material by mixing a dispersion comprising a plasticizer and cellulose nanowhiskers into a carbon matrix. The nanowhiskers are dispersed in a liquid dispersion and pumped into an extruder in which is arranged the at least partially molten carbon matrix. The extrusion process will thoroughly mix the cellulose whiskers into the carbon matrix, thus providing a homogenous mixture being highly reinforced. The present invention further discloses a polymer produced according to the above process comprising a CAB/CNW mixture, as well as a process for producing said whiskers.
    Type: Application
    Filed: November 15, 2006
    Publication date: May 8, 2008
    Applicant: NTNU Technology Transfer AS
    Inventors: Kristiina Oksman, Daniel Bondeson, Peder Syre
  • Publication number: 20080020948
    Abstract: Sulfonated graft copolymer obtained by radical graft copolymerization of one or more synthetic monomers in the presence of hydroxyl-containing naturally derived materials. The graft copolymer includes 0.1 to 100 wt %, based on weight of the total synthetic monomers, of at least one monoethylenically unsaturated monomer having a sulfonic acid group, monoethylenically unsaturated sulfuric acid ester or salt thereof, with the monomer and hydroxyl-containing naturally derived materials present in a weight ratio of 5:95 to 95:5.
    Type: Application
    Filed: July 20, 2007
    Publication date: January 24, 2008
    Inventors: Klin A. Rodrigues, Jannifer Sanders
  • Patent number: 7144852
    Abstract: The present invention is directed to a process for the preparation of polysaccharide-grafted polymer particles wherein the polysaccharide is preferably a ?-1,4 linked polysaccharide, comprising miniemulsion polymerisation.
    Type: Grant
    Filed: June 6, 2005
    Date of Patent: December 5, 2006
    Assignee: Unilever Home & Personal Care USA division of Conopco, Inc.
    Inventors: Paul Ferguson, Christopher Clarkson Jones, Paul Simon Stevenson
  • Patent number: 7078462
    Abstract: An automatic laundry or dishwashing product in unit dose form comprising at least three distinct zones for delivering into at least three different stages in the washing cycle. The product provides improved cleaning, care and finishing benefits.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: July 18, 2006
    Assignee: The Procter & Gamble Company
    Inventors: Lynda Anne Speed, Glenn Steven Ward
  • Patent number: 6908976
    Abstract: A solution for forming a graft substrate containing a graft initiator, a catalyst for activating the graft initiator, a polymerizable silicon softener, and at least one additional prepolymer, each of the softener and the prepolymer which includes a functional group for reaction with an activated site on the substrate for grafting thereto and water. The treated fiber exhibits excellent crockfastness, color fastness, and abrasion resistance, strength, and has a soft hand.
    Type: Grant
    Filed: October 2, 2003
    Date of Patent: June 21, 2005
    Assignee: Healthtex Apparel Corp.
    Inventors: Mohan L. Sanduja, Carl Horowitz, Izabella Zilbert, Paul Thottathil, Gerald L. Williamson
  • Patent number: 6835767
    Abstract: A polymer dispersion is prepared by copolymerization of from 20 to 70 parts by weight of a monomer mixture comprising a) from 2.5 to 100% by weight of one or more (meth)acrylates of monohydric, saturated C3-C8-alcohols as monomers A and b) from 0 to 97.5% by weight of one or more further ethylenically unsaturated monomers as monomers B in 100 parts by weight of an aqueous solution which contains from 5 to 35% by weight of a starch or of a starch derivative by emulsion polymerization in the presence of an initiator containing peroxide groups, by a process in which the initiator and monomers are metered in continuously and wherein, a first amount of initiator is metered in over a first feed period of from 5 to 60 minutes and a second amount of initiator is metered in over a second feed period of from 15 to 180 minutes, the first amount of initiator being greater than the second amount of initiator.
    Type: Grant
    Filed: February 7, 2003
    Date of Patent: December 28, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Ingolf Kühn, Rudolf Schuhmacher
  • Publication number: 20040068073
    Abstract: Methods of making and using starch graft copolymers produce particle sizes useful in granule applicators for applying to agricultural fields. Starch graft copolymers on field crops provide excellent anti-crusting properties, increased seed germination and stand, increased crop growth, increased crop yields and reduced water requirements.
    Type: Application
    Filed: October 7, 2002
    Publication date: April 8, 2004
    Inventors: Steven William Doane, William McKee Doane