Sterilizing Complete Package Patents (Class 53/425)
  • Patent number: 11186474
    Abstract: A method of decontaminating an aseptic filling apparatus that includes stations including a content filling station arranged from an upstream side to a downstream side of a flow of a preform or container, and each of the stations is covered by a chamber. The method includes sterilizing the content filling station by performing a CIP and then an SIP or performing an SIP serving also as a CIP of the content filling station, removing a cleaning liquid used in the CIP or SIP, and performing a COP and/or an SOP of the various kinds of stations in a predetermined order. A first SOP using a first sterilizer and a second SOP using a second sterilizer are performed stepwise on the various kinds of stations while the CIP and the SIP or the SIP serving also as the CIP are being performed on the content filling station.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: November 30, 2021
    Assignee: Dai Nippon Printing Co., Ltd.
    Inventors: Atsushi Hayakawa, Ryuichi Tamagawa
  • Patent number: 11160951
    Abstract: A packaging system and method for reducing or eliminating exposure of medical devices to whole-room disinfecting gases and vapors are disclosed. In some embodiments, the packaging system and method may comprise a diffusion inhibitor member configured as an open-ended bag. In some embodiments, the diffusion inhibitor member comprises polyethylene or polypropylene.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: November 2, 2021
    Assignee: Merit Medical Systems, Inc.
    Inventors: Jim Mottola, Steven Weir, Richard A. Brotherton, Elena Agafonova
  • Patent number: 10988274
    Abstract: A package system suitable for sterilizing cyanoacrylate compositions and providing the sterile cyanoacrylate compositions a shelf life of at least 24 months, wherein the package system comprises: an ampoule comprising a chamber comprising a cyanoacrylate monomer, wherein the chamber is defined by an opening and sidewalls, wherein the ampoule comprises a material comprising a cyclic olefin copolymer; a multilayer foil seal sealing the opening of the ampoule; and a secondary package housing the ampoule.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: April 27, 2021
    Assignee: ADHEZION BIOMEDICAL, LLC
    Inventors: Sheng Zhang, Rafael Ruiz, Sr., Amanda Guido
  • Patent number: 10961340
    Abstract: A method forming a surface modifying composition with reduced need for organic solvent and evaporation thereof for removal of insoluble reaction byproducts from the composition. The purified composition can be used in the formation of articles having improved biocompatibility, such as medical articles (e.g., spun hollow fiber).
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: March 30, 2021
    Assignee: FRESENIUS MEDICAL CARE HOLDINGS, INC.
    Inventors: Jiunn Teo, Craig Kamerath, Praveen Kosaraju, Monica P. Hall
  • Patent number: 10434119
    Abstract: A storage stable package is provided that includes a polymeric bottle having a volume filled with an aqueous saline composition acidified with an acid to a pH of 2 to 9 and having a hypertonic saline concentration relative to saliva and blood, or an aqueous hydrogen peroxide composition acidified with an acid to a pH of 2.7 to 5.3 and having a hydrogen peroxide concentration 0.5 to 3 total weight percent, either to achieve a storage stability at 20 degrees Celsius of the composition of at least 10 weeks. The aqueous composition is independent of a synthetic antimicrobial. A cap is provided that is complementary a package opening for selectively sealing the aqueous saline composition within the volume. A process for treating an infection of a pharyngeal or buccal cavity is provided that includes rinsing with one of the aqueous saline composition. The aqueous saline composition is then expectorated.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: October 8, 2019
    Assignee: Gargle Water, Inc.
    Inventors: Jehangir Gowani, Ian Vonwald, Xiaojiang Wang, Evan Boyst, Shri Thanedar
  • Patent number: 10410453
    Abstract: Methods of marking plastic-based products and marked plastic-based products are provided. Some methods include irradiating the product to alter the functionalization of the plastic. In general, the present disclosure features methods of marking substrates, e.g., substrates including plastics, such as plastic-based products, such as polymer banknotes. Such plastics can be rigid or flexible, e.g., elastomeric. Such plastics can be thermoplastic or thermosets. In some cases, the products are marked by irradiating plastic-based materials, e.g., sheet materials, under conditions that alter characteristics of the irradiated plastic.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: September 10, 2019
    Assignee: Xyleco, Inc.
    Inventor: Marshall Medoff
  • Patent number: 10351305
    Abstract: The invention provides a sterilizable pouch having at least one wall formed of a flexible film and including an opening formed therein for providing communication to an interior space of the package. A breathable material is disposed on an outer surface of the wall covering the opening. The breathable material is joined to the outer surface of the wall with a continuous heat seal. A heat resistant material is positioned between the breathable material an outer surface of the wall.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: July 16, 2019
    Assignee: AMCOR FLEXIBLES, INC.
    Inventors: Adam Jan Dworak, Brian Ingraham
  • Patent number: 10307776
    Abstract: The invention relates to a device for packaging and dispensing a fluid product, having a leaktight flexible pouch (1) placed in a rigid bottle (10) and associated with a pump or a valve (13), this pouch having a cylindrical wall consisting of a sheet (2) rolled into a cylinder, one edge of which is fixed in a leaktight fashion to a flange forming a ring for fastening to the bottle and to the pump or the valve, this flange (4) consisting of a plastic material, the other edge of the said sheet is fixed in a leaktight fashion to a second flange forming the bottom of the pouch, this second flange (3) consisting of a plastic material, these flanges (3, 4) having a solid disk or a ring having a raised edge (3A, 4A) forming an annular lateral surface, to which the edge of the said sheet (2) forming the wall of the pouch is fixed, the said sheet (2) of the cylindrical wall being a multilayer sheet having at least one inner film of plastic material.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: June 4, 2019
    Assignee: LABLABO
    Inventors: Jean-Philippe Taberlet, Alain Guy, Patrice Puviland
  • Patent number: 10254567
    Abstract: Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: April 9, 2019
    Assignee: Novartis AG
    Inventors: Frank Chang, Ryan DeSousa, Troy Vernon Holland, John Dallas Pruitt, Jared Nelson
  • Patent number: 10245336
    Abstract: A system for handling the sterilization of thin-body, pouch-type, flexible containers (1), provides for applying sacrificial closures (200) to the pouches, loading the provisional closed pouches to be sterilized on a transport device (300) for collective transport, to performing the sterilization of the transport device (300) carrying the provisional closed pouches and, finally, separating, in a sterile chamber, the sacrificial closures (200) from the pouches, performing filling and applying an inviolable cap (100).
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: April 2, 2019
    Assignee: Guala Pack S.P.A.
    Inventor: Stefano Tamarindo
  • Patent number: 10189589
    Abstract: The present invention relates to a chamber machine for packaging products in at least one bag, where said chamber machine includes at least one gas nozzle. The chamber machine can also include a monitoring device configured for detecting the presence of a bag neck of the bag over the gas nozzle.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: January 29, 2019
    Assignee: Multivac Sepp Haggenmueller SE & Co. KG
    Inventors: Konrad Möβnang, Benjamin Öfele, Thomas Pfalzer, Klaus Rothermel
  • Patent number: 10191025
    Abstract: The present invention provides a medical device to provide an alert of the potential detection of a disease in an infrastructure having a chamber of air and a geographic location, the device comprising: one or more sample ports of known sub-location within the infrastructure, the one or more sample ports being open to a designated part of the infrastructure and a sample of air from the air chamber being operable to pass through the one or more sample ports; a detector to receive the sample of air from a specific one of the one or more sample ports and being operable to generate molecular characteristic data for identifying diseases from the sample of air; a processor operable to analyze the molecular characteristic data from the sample of air; and an alert module operable to issue an alert output in response to the detection of particular molecular characteristic data from the sample of air.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: January 29, 2019
    Assignee: Al Azri, Sultan Sultan Hamad Mohammed
    Inventor: Sultan Sultan Hamad Mohammed Al Azri
  • Patent number: 10139291
    Abstract: Disclosed is a method for calibrating a sensor of a monitoring apparatus for monitoring an analyte concentration in a body fluid sample of a patient in which a temperature-dependent drift model is derived for the sensor. An apparatus for monitoring an analyte concentration in a body fluid sample of a patient including such a sensor and a signal processor programmed to calibrate the sensor in accordance with this method is also disclosed.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: November 27, 2018
    Assignee: Sphere Medical Limited
    Inventors: Neil Todd, Steven Fowler, Gavin Lucius Troughton
  • Patent number: 10004820
    Abstract: A container for washing, sterilization, transportation and sterile storage of articles for sterilization is provided. The container includes a sleeve and a frame adapted to receive articles for sterilization. The container includes at least one filtered opening to permit communication between the sterilization apparatus and the sterilization chamber for the communication of steam and air. In a first configuration, a front and rear wall of the frame engage the sleeve to create a sterilization chamber. The container may be stacked and stored in any orientation. In a second configuration, the frame rests or nests on top of the sleeve to permit access to and use of the sterilized articles. The container, may include one or a plurality of openings for communication between a sterilization apparatus and the sterilization chamber and one or more filters adjacent to the pluralities of openings.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: June 26, 2018
    Assignee: SciCan Ltd.
    Inventors: Arthur Zwingenberger, Robert Biermann, Andy Kwan-Leung Sun
  • Patent number: 9610385
    Abstract: This invention relates to an method of manufacture of an implantable medical device comprising an oxygen-sensitive rapamycin derivative that is protected by addition of an antioxidant during the manufacturing process where the amount of antioxidant added at the outset of the processing is such that when the device is fully fabricated, sterilized and packaged the amount of antioxidant has reduced to a minimal, preferably non-detect, amount.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: April 4, 2017
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Stephen D. Pacetti, Julia Fox
  • Patent number: 9482788
    Abstract: The present disclosure provides a UV-blocking silicone hydrogel composition including a hydrophilic silicone macromer, a UV-blocking monomer, a first hydrophilic monomer, a crosslinker and a polymerization initiator. The hydrophilic silicone macromer has a general formula: V-L-S-(L?-V?)x, wherein V and V? are independently ethylenically-based polymerizable groups, L and L? are independently a covalent bond or a linkage group, S is a siloxane group having a chemical structure such as and x is 0 or 1. A silicone contact lens containing the UV-blocking silicone hydrogel composition is also provided herein.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: November 1, 2016
    Assignee: PEGAVISION CORPORATION
    Inventors: Yu-Chin Lai, Min-Tzung Yeh, Han-Yi Chang, Heng-Yi Li, Hung-Ju Chang, Che-Cheng Wu
  • Patent number: 9339573
    Abstract: An apparatus (1) for the sterilization of plastics material containers (10), and in particular of plastics material pre-forms (10), with a conveying device (2) which conveys the plastics material containers (10) along a pre-set conveying path, with at least one stressing device (4) which acts upon an external surface of the plastics material containers to be sterilized with a flowable medium. According to the invention the stressing device is arranged in such a way that it acts upon a pre-set area of the plastics material containers (10)—situated below an aperture of the plastics material pre-forms—with the sterilization medium.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: May 17, 2016
    Assignee: KRONES AG
    Inventors: Katharina Seidenberg, Bettina Kohl, Michael Loy, Juergen Soellner, Marina Goldbach, Robert Schmitt, Ute Bedoe
  • Patent number: 9193487
    Abstract: A method of packaging a food product using a polymer membrane, the polymer being a self assembling polymeric material, and the method including a.) rendering the said polymer into a film; and b.) packaging a food product in an atmosphere with the said polymer film, wherein said film regulates the atmosphere in which the food product is packaged.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: November 24, 2015
    Inventors: Scott T. Matteucci, Leonardo C. Lopez, Shawn D. Feist, Peter N. Nickias, Shrikant N. Khot
  • Patent number: 9169033
    Abstract: A sealing station for a packaging machine comprises a sealing tool for sealing packages, an underpressure source for evacuating packages in the sealing station, and an overpressure source for providing compressed air so as to press the sealing tool against a package. A single drive is provided for the underpressure source and the overpressure source, the underpressure source and/or the overpressure source being a pump that is configured as a rotary vane pump or as a helical pump.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: October 27, 2015
    Assignee: MULTIVAC SEPP HAGGENMULLER GMBH & CO. KG
    Inventors: Elmar Ehrmann, Herbert Kirmse
  • Publication number: 20150135644
    Abstract: A wound dressing comprising acylated chitosan fibre. The dressing has a wet strength of 0.3 N/cm or above. The acylated chitosan fibre may have a degree of substitution of 0.10-0.50. The acylated chitosan fibre may preferably have a degree of substitution of 0.20-0.40. The dressing may have an absorbency of 5-25 g/g of a solution containing 8.298 g/l of sodium chloride and 0.368 g/l of calcium chloride dehydrate as measured by BSEN 13726-12002 Part 1 Aspects of Absorbency. The base material of the dressing may be chitosan fibre that has been chemically modified through an acylation process using anhydride and ethanol as the solvent. A method of manufacturing the wound dressing involves reacting chitosan fibre with anhydride and making acylated chitosan felt through a nonwoven process, and through cutting, packing and sterilizing processes.
    Type: Application
    Filed: January 17, 2012
    Publication date: May 21, 2015
    Inventors: Xiaohui Mo, Xiaodong Wang, Zhenjun Wu
  • Publication number: 20150141994
    Abstract: An intramedullary orthopedic implant includes a body section having a first end that provides a point of insertion for the body section and a second end. The body section further includes wings extending away from the point of insertion for the body section. The intramedullary orthopedic implant further includes first and second legs extending from the second end of the body section. The first and second legs begin in a first implanted shape, are movable to a second insertion shape, and remain in the second insertion shape as long as the first and second legs are mechanically constrained.
    Type: Application
    Filed: September 16, 2014
    Publication date: May 21, 2015
    Applicant: BioMedical Enterprises, Inc.
    Inventors: Daniel F. Cheney, David J. Pancratz
  • Publication number: 20150141454
    Abstract: The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
    Type: Application
    Filed: January 15, 2015
    Publication date: May 21, 2015
    Inventors: Giorgio Calderari, Daniele Bonadeo, Roberta Cannella, Alberto Macciocchi, Andrew Miksztal, Thomas Malefyt, Kathleen M Lee
  • Patent number: 9034250
    Abstract: An integrated lancing test strip includes a test strip and a lancet packet coupled to the test strip. The lancet packet includes a sterility sheet enclosing a lancet to maintain the sterility of the lancet and prevent cross-contamination between the test strip and the lancet. The sterility sheet allows the lancet to be sterilized separately from the test strip. The sterility sheet gives the integrated strip a low profile, which is attractive for packaging multiple integrated strips in cassettes, drums, magazines or the like. In one form, the integrated strip is loaded in a meter that includes an adjustment mechanism that adjusts the position of the test strip relative to the skin being sampled. This allows the user to adjust the position of the test strip so as to not apply excessive pressure against skin, which could hamper bleeding from the incision in the skin.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: May 19, 2015
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Steven N. Roe
  • Publication number: 20150128527
    Abstract: Methods of stabilizing the molecular weight of polymer stents scaffolds after E-beam sterilization are disclosed. The molecular weight of the polymer of the irradiated scaffolds is stabilized through exposure to gas containing oxygen.
    Type: Application
    Filed: January 14, 2015
    Publication date: May 14, 2015
    Inventors: Yunbing Wang, Derek Mortisen, Xiao Ma, Fuh-Wei Tang, Byron Lambert
  • Publication number: 20150133944
    Abstract: A bone depth gauge having a distal handle to which a tip is releasably connected. The tip is formed by photochemical machining to produce a tip and hook on the distal end with an approximate hexagonal cross section. The manufacturing costs of the tip are low enough to provide it in a one use package. A tubular element is releasably telescoped over the tip and handle to enable determination of the depth of a hole formed in a bone.
    Type: Application
    Filed: November 11, 2013
    Publication date: May 14, 2015
    Applicant: BIOMET MANUFACTURING, LLC.
    Inventor: Juergen Kortenbach
  • Publication number: 20150129437
    Abstract: Disclosed is a stack of individually separable packages for a plurality of contact lenses, each individual lens being packaged between a first surface and a second surface, wherein the first surface is provided by a first one of the individually separable packages and the second surface is provided by a second one of the individually separable packages.
    Type: Application
    Filed: November 25, 2013
    Publication date: May 14, 2015
    Applicant: Contact Lens Precision Laboratories Ltd.
    Inventors: John CLAMP, Richard NEWELL
  • Patent number: 9027311
    Abstract: A method of sterilizing items by placing items to be sterilized into a puncture resistant sealable vapor barrier sterilization bag, performing steam sterilization under pressure via a conduit coupled to the bag while maintaining a heated compensating pressure environment around the exterior of the bag during steam sterilization so as to reduce mechanical stress on the bag and sealing the bag at the completion of sterilization. There is also provided a sterilization services apparatus for sterilizing the contents of a sterilization bag including a pressure compensating compartment having a sealable door that maintains a heated compensating pressure environment around the exterior of a sterilization bag during steam sterilization so as to reduce mechanical stress on the bag.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: May 12, 2015
    Assignee: Mercer Technologies Limited
    Inventors: Terry Dean Kemp, Christo Andre De Klerk
  • Patent number: 9022079
    Abstract: A container and method are provided for storing fat containing liquid products. The container includes a body defining a storage chamber for receiving the product, and a container closure. A first material portion forms at least most of the surface area overlying the storage chamber that can contact any product therein. Neither the body nor the first material portion leach more than a predetermined amount of leachables into the product or undesirably alter a taste profile thereof. A needle penetrable and thermally resealable second material portion either (i) overlies the first material portion and cannot contact any product within the storage chamber, or (ii) forms a substantially lesser surface area overlying the storage chamber that can contact any product therein in comparison to the first material portion. A sealing portion is engageable with the body to form a substantially dry hermetic seal between the container closure and body.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: May 5, 2015
    Assignee: MedInstill Development LLC
    Inventors: Daniel Py, Norbert Assion, Nathaniel Houle, Debashis Sahoo, M. Jeffrey Willey, Eric E. Hartman, John Guthy
  • Publication number: 20150096264
    Abstract: The present invention presents methods for making oxidation-resistant and wear-resistant polyethylenes and medical implants made therefrom. Preferably, the implants are components of prosthetic joints, e.g., a bearing component of an artificial hip or knee joint. The resulting oxidation-resistant and wear-resistant polyethylenes and implants are also disclosed.
    Type: Application
    Filed: December 10, 2014
    Publication date: April 9, 2015
    Inventors: Harry A. McKellop, Fu-Wen Shen
  • Publication number: 20150083627
    Abstract: The present invention provides a gas permeable sterilization and shipping package system for medical products. The system includes a gas permeable sterilization package composed of an upper panel and a lower panel. Each panel has a main panel element, panel edges, and panel margins at or near the panel edges. The upper panel and the lower panel are joined at their respective panel margins so the respective main panel elements define a compartment for holding one or more articles to be sterilized. At least a portion of at least one panel is permeable to sterilant gas. The system includes at least one reinforcement strip joined to a panel at least at one location on its main panel element between its panel margins. Also disclosed is a method of sterilizing and shipping one or more items used in a medical procedure by utilizing the gas permeable sterilization and shipping package system.
    Type: Application
    Filed: September 26, 2013
    Publication date: March 26, 2015
    Applicant: Kimberly-Clark Worldwide, Inc.
    Inventor: Sean P. Gorman
  • Publication number: 20150082749
    Abstract: The invention relates to a metal can (40) for preserving a food product sterilised by heat treatment after closing the can, made up of an integral body forming the bottom (41) and the side wall (43) of the can, and a lid (42) mounted on said body in order to seal the latter, the minimum thickness of the side wall (43) being between 20% and 60% of the thickness of the centre of the bottom (41). According to the invention, the height of the can (40) is between 1.5 and 3.5 times the width thereof, and the bottom (41) and/or the lid (42) of the can has a central wall (411, 421) with an outwardly convex shape, connected to the side wall (43) by a peripheral groove (410) opening up towards the outside.
    Type: Application
    Filed: November 26, 2014
    Publication date: March 26, 2015
    Applicant: ARDAGH MP GROUP NETHERLANDS B.V.
    Inventor: Franck DATHY
  • Publication number: 20150068927
    Abstract: A method of making a ready-to-use catheter assembly and a ready-to-use catheter are provided, which avoids any degradation of the catheter during sterilization. The method comprises: placing a catheter with a hydrophilic coating and a wetting fluid in a catheter package made of low moisture transmission material while the package is in a first condition wherein an insertable length of the hydrophilic coating of the catheter is not in contact with the wetting fluid, sterilizing the catheter package with the catheter and the wetting fluid by radiation sterilization while the catheter package is kept in a condition in which the insertable length is not in contact with the wetting fluid, transferring the catheter package with the catheter and the wetting fluid into a second condition, bringing the wetting fluid into contact with at least the insertable length and activating the insertable length via gravity and/or via inertia.
    Type: Application
    Filed: September 9, 2014
    Publication date: March 12, 2015
    Inventors: Denzell McBURNEY, Morgan TIERNEY, Ronald John KELLY
  • Publication number: 20150068928
    Abstract: A protective cover for a nasal cannula completely encloses the two prongs of the nasal cannula when properly installed. This protective cover will keep the nasal cannula from contacting potentially unclean surfaces when the nasal cannula is not in use. An optional UV light may be present in the protective cover to provide UV cleaning of the nasal cannula prongs when the cover is closed.
    Type: Application
    Filed: November 17, 2014
    Publication date: March 12, 2015
    Inventor: Charles Andrew Turner
  • Publication number: 20150044640
    Abstract: An endodontic post assembly includes a connecting member and a plurality of post structures. The connecting member includes a base and a plurality of connecting nodes connected to the base. Each of the post structures has a root portion connected to a respective one of the connecting nodes, and an apical portion opposite to the root portion. A method of producing the endodontic post assembly and a method of using a sterilization package in endodontic treatment are also provided.
    Type: Application
    Filed: January 10, 2014
    Publication date: February 12, 2015
    Applicant: TAIWAN GREEN POINT ENTERPRISES CO., LTD.
    Inventor: Pi-Ying LIU
  • Patent number: 8950576
    Abstract: The present invention relates to bags made from medical-grade paper for sterilization, with sterilization-process indicators and pigmented-adhesive-based safety features, which is easy to handle and use and can be used to store materials, more particularly surgical medical material, for sterilization. Such bags are produced using medical-grade paper that is treated on the surface thereof with a microbiocide for sterilization, and, owing to the structure and design thereof, allow safe, rapid handling of the sterilized material placed within, since there are visual indicators that guarantee the hermetic closure and sealing thereof. Furthermore, generally, the invention has printed indicators that change color depending on the sterilization process carried out on the bags and on whether said process was carried out correctly.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: February 10, 2015
    Inventor: Albert Pla Andreu
  • Patent number: 8944079
    Abstract: The invention relates to a device and a method for filling or packing contents, particularly beverages, food, medications, or the like, into containers. As the containers pass through the device from an inlet to an outlet side, the containers passing through the working chamber have a sterile fluid, particularly sterile air, applied thereto for preventing germ growth. In order to reduce the cleaning effort for lines for the sterile fluid, the invention proposes that a cleaning medium having an internal line is inserted into the line for applying the sterile fluid. The line no longer needs to be disassembled in order to load the sterile fluid. In order to distribute the sterile fluid uniformly throughout the containers in a working chamber, the sterile fluid is distributed in two stages, first by means of the pipe extending into the working chamber, as described above and then through a profile extending over the containers and below the pipe, having openings for passing the sterile fluid.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: February 3, 2015
    Assignee: Elopak Systems AG
    Inventors: Dirk Auer, Sergey Anokhin
  • Publication number: 20150027087
    Abstract: Disclosed is a container sealant composition with improved tensile strength and reduced squeeze-out during seaming. The composition comprises a latex of a carboxylated styrene-butadiene rubber, a colloidal silica filler, wherein the colloidal silica is pretreated with an organosilane, and a tackifier. Also disclosed is a method of sealing a can with the aforedescribed container sealant composition.
    Type: Application
    Filed: December 19, 2012
    Publication date: January 29, 2015
    Inventors: Qi Sun, Toru Takahashi, Yasushi Ikeshiro
  • Publication number: 20150001261
    Abstract: The present invention provides a slider valve assembly for connection to a spout of an aseptically-packaged flexible container for filling and dispensing flowable material. The slider valve assembly comprises a cap member, a valve member, and an outlet member. The cap member has a central opening and is adapted to be secured to the spout of the container. The valve member defines one or more side openings in communication with a central bore, is slidable within the central opening of the cap member and is lockable into a closed or open position. The outlet member is detachably engaged to the valve member and is used for actuating the valve member. The outlet member also defines a hollow interior portion which is in communication with the central bore of the valve member.
    Type: Application
    Filed: June 27, 2014
    Publication date: January 1, 2015
    Inventor: James W. Johnson
  • Patent number: 8919080
    Abstract: The disclosure relates to a packaging machine for packaging products, in particular food, wherein the packaging machine comprises at least one packaging station for producing packagings that accommodate products, and at least one high-pressure treatment station for high-pressure treatment of the products contained in the packagings. The disclosure is characterized in that a central control system for the packaging station and the high-pressure treatment station are provided. The disclosure moreover also relates to a method for operating such a packaging machine.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: December 30, 2014
    Assignee: Multivac Sepp Haggenmueller GmbH & Co. KG
    Inventor: Tobias Richter
  • Patent number: 8887477
    Abstract: The invention provides a method for single-step terminal sterilization process for bio-active heparin coatings on materials and biomaterials containing heparin used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombotic and biocompatible heparin surfaces. Other relevant device examples may include heparin or a heparin derivative coated stents to reduce clotting and restenosis, dental or ophthalmological implants. These materials may comprise additional polymeric compositions such as polyethyleneimine, dextran sulfate or their modified forms. These polymers together with heparin coatings may be applied to other substrate of medical devices such as metal, ceramics or biologically derived materials.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: November 18, 2014
    Inventors: Robert Falotico, Chengxue Li, Thai M. Nguyen, Theodore L. Parker, Jonathon Z. Zhao
  • Publication number: 20140319005
    Abstract: The present invention relates to packaging material for contrast media and more specifically to packages comprising containers filled with contrast media and closed with a closure means. In particular, the invention relates to packaging material comprising closure means comprising Carbon Black. The invention further relates to methods for improving the stability of such contrast media during storage, and in particular the method includes filling the contrast media in a container and closing the container with a closure means comprising Carbon Black.
    Type: Application
    Filed: September 20, 2012
    Publication date: October 30, 2014
    Inventors: Bente Jachwitz, Christian Glogard
  • Patent number: 8869496
    Abstract: A device for filling containers with liquid may include a first transport, which transports a plurality of containers through a filling chamber. The filling chamber may include a sterile space. A plurality of treatment members may be arranged in the filling chamber for treating the containers, with at least one of these treatment members being a filling member which fills the containers with the liquid. The first transport may be designed in such a way that it transports the containers through the filling chamber in a cyclic manner.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: October 28, 2014
    Assignee: Krones AG
    Inventors: Roland Laumer, Johann Justl
  • Publication number: 20140311094
    Abstract: The presently disclosed subject matter relates generally to methods of generating at least one disinfecting gas within a package through a photochemical reaction. More particularly, the disclosed methods include incorporating a composition capable of generating a gas upon exposure to light into the disclosed package. As set forth in detail herein below, the amount of moisture present in the disclosed composition is directly related to the production rate of the gas. Accordingly, the amount of gas generation can be controlled by varying the amount of moisture present in the composition.
    Type: Application
    Filed: March 14, 2014
    Publication date: October 23, 2014
    Applicant: CRYOVAC, INC.
    Inventors: Patrick W. Thompson, Joshua D. Wofford
  • Patent number: 8865789
    Abstract: Silicone hydrogel contact lenses that have good dimensional stability, are ophthalmically-acceptable, and can be manufactured without the use of alcohol solvents are formed from the reaction product of a polymerizable composition comprising at least one mono-functional acrylate-containing siloxane monomer having a molecular weight of less than 2,000; at least one bi-functional acrylate-containing siloxane monomer having a molecular weight of at least 3,000; and at least one hydrophilic vinyl-containing monomer, wherein the polymerizable composition has a molar ratio of total amount of mono-functional acrylate-containing siloxane monomer to total amount of bi-functional acrylate-containing siloxane monomer of at least 30:1, respectively.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: October 21, 2014
    Assignee: CooperVision International Holding Company, LP
    Inventors: Li Yao, Ye Hong, Yuwen Liu, Charlie Chen, Charles A. Francis, Arthur Back
  • Patent number: 8863790
    Abstract: An apparatus for filling containers, has an entrance through which open containers can be introduced into the apparatus, including at least one transport device which conveys the containers along a predefined transport path, and an exit via which the containers can be discharged from the apparatus. The speed at which the transport device conveys the containers is variable, and the apparatus comprises at least one filling device which fills the containers at least partially with a liquid medium on the transport path between the entrance and the exit. The apparatus includes a housing, and arranged in the interior of the housing is at least one sterilization device in the form of a ?-radiation unit which sterilizes components of the apparatus.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: October 21, 2014
    Assignee: Krones AG
    Inventors: Manfred Ziegler, Jochen Krueger
  • Patent number: 8857478
    Abstract: An apparatus for treating containers may include a treatment chamber in which the containers are treated, and a conveyor unit which transports the containers within the treatment chamber. The treatment chamber can be isolated by means of at least one wall from an environment external of the treatment chamber in such a way that sterile conditions can be achieved in the treatment chamber, and by means of at least one treatment unit which treats the containers within the treatment chamber. At least one wall of the treatment chamber is arranged to be movable. A sealing assembly seals the treatment chamber in an area with regard to elements of the apparatus, which are movable relative to each other, against the environment external of the treatment chamber. The sealing assembly includes a surrounding channel, into which a liquid sealing agent can be introduced, as well as a secondary wall which is arranged within the channel at least in sections.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: October 14, 2014
    Assignee: Krones AG
    Inventors: Hermann Klarl, Roland Laumer
  • Publication number: 20140303254
    Abstract: A process for minimizing formation of a highest degradation product during moist heat sterilization of a drug solution of an oxidation susceptible active pharmaceutical ingredient is provided. The oxidation susceptible active pharmaceutical ingredient is mixed with excipients and deoxygenated water to prepare a non-sterile drug solution. The non-sterile drug solution is filled into a moist heat sterilizable flexible infusion bag. The flexible infusion bag with the non-sterile drug solution is terminally moist heat sterilized at a preset air overpressure between about 0.2 bar to about 1.2 bar to obtain a parenteral drug product. The highest degradation product in the parenteral drug product is less than 0.5% by weight of a labeled amount of the oxidation susceptible active pharmaceutical ingredient in the parenteral drug product.
    Type: Application
    Filed: April 5, 2014
    Publication date: October 9, 2014
    Inventors: Tushar Hingorani, Kumaresh Soppimath, Rekha Nayak, Tushar Malkan, Satish Pejaver, Navneet Puri
  • Patent number: 8845977
    Abstract: An apparatus for transporting objects and in particular containers, having a first conveyor which transports the objects along a specified transport path (P), including a sterile room, within which the objects are transported, and including a second conveyor which follows on from the first conveyor. According to the invention, the first conveyor is positioned completely inside of the sterile room and the second conveyor is positioned completely outside of the sterile room, wherein both the first conveyor and the second conveyor are preferably positioned in a specified transitional area (B) along the transport path (P).
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: September 30, 2014
    Assignee: Krones AG
    Inventors: Manfred Schmid, Juergen Soellner
  • Publication number: 20140283485
    Abstract: Methods for making an using convenience kits for hazardous drug (liquid) transfer from vials to syringes and target IV connectors. The following methods for making and using are disclosed: (1) Using a conventional plastic bag as a vial and vial adapter enclosing shroud. (2) Using of a flange (i.e. latch arm) free vial adapter which may, therefore, be used for a large variety of vial sizes. (3) Providing a seal about an access hole through which a vial adapter dispensing portion provides a closed fluid dispensing pathway. (4) Using the shrouding bag and an associated elastic band to provide desired stability of a spiked vial. (5) Accessing, measuring and transferring vial contents directly from a vial to a target IV container via an elongated connecting tube.
    Type: Application
    Filed: March 19, 2013
    Publication date: September 25, 2014
    Inventors: Gale Harrison Thorne,, JR., Kendall Patterick Thorne, Gale Harrison Thorne
  • Publication number: 20140262915
    Abstract: A ready-to-use injectable, co-solvents (ternary mixture) pharmaceutical composition for the treatment of cardiac conditions and diagnosis applications, comprising methyl-3-[4-(2-hydroxy-3-isopropylamino)propoxy]phenylpropionate hydrochloride (Esmolol hydrochloride), a buffering agent, ethanol and propylene glycol. The ready-to-use injectable, co-solvents (ternary mixture) pharmaceutical composition is capable of being stored in a modified flexible plastic container that may be heat-sterilized without deformation and/or without having the integrity of the closure system being compromised. A method for the manufacture of the ready-to-use injectable, co-solvents (ternary mixture) pharmaceutical composition is also disclosed.
    Type: Application
    Filed: August 22, 2013
    Publication date: September 18, 2014
    Applicants: HQ SPECIALTY PHARMA CORPORATION, WELGRACE RESEARCH GROUP
    Inventors: George Owoo, Erica Castagna