Abstract: A novel contact lens package containing a silicone hydrogel soft contact lens, which can be offered to the market in a hermetically sealed preserved state with excellent shape stability (dimensional stability). Also provided is a manufacturing method of the same. The novel contact lens package is manufactured by using a silicone hydrogel contact lens as a soft contact lens, sealing both a storage solution so as to contain a phosphoric acid and the silicone hydrogel contact lens in a housing area of a contact lens package, and then performing high pressure steam sterilization processing.

Abstract: A sterile enclosure contains a transfer module defining a window. A port covers the window to maintain the inside of the enclosure as a sealed and sterile environment. A sliding, heated cutting element mounted on the port serves to sterilize and sever a portion of a sterile transfer bag assembly attached to the port. Preferably, the excised portion of the sterile transfer bag assembly is affixed to the port when the port opens. The sliding cutting element remains extended and heated to prevent contamination when the port is open. Further, a heating element is mounted about the window in order to sterilize around the opening when the port is open.

Abstract: A glucose sensor product is manufactured by a process that maintains the sterility of the glucose sensor while allowing gaseous manufacturing by-products to be vented from the inside of the glucose sensor package. The method begins by placing a glucose sensor assembly into a plastic package tray having a sealing surface surrounding an opening. The method continues by covering the opening with a microbial barrier material such that the microbial barrier material overlies the sealing surface, forming a seal between the sealing surface and the microbial barrier material, resulting in a sealed package tray containing the glucose sensor assembly, and sterilizing the glucose sensor assembly inside the sealed package tray. The microbial barrier material maintains sterility of the glucose sensor assembly while allowing volatile by-products outgassed from the glucose sensor assembly and the plastic package tray to pass therethrough.

Abstract: Silicone hydrogel contact lenses are produced without using volatile organic solvents to extract materials from the polymerized contact lens bodies, and instead are washed with aqueous liquids. The silicone hydrogel contact lenses so produced have ophthalmically wettable lens surfaces. The hydrated silicone hydrogel contact lenses have diameters that are at least 24% larger than the diameters of the silicone hydrogel contact lenses prior to hydration or washing.

Abstract: Silicone hydrogel contact lenses that have good dimensional stability, are ophthalmically-acceptable, and can be manufactured without the use of alcohol solvents are formed from the reaction product of a polymerizable composition comprising at least one mono-functional acrylate-containing siloxane monomer having a molecular weight of less than 2,000; at least one bi-functional acrylate-containing siloxane monomer having a molecular weight of at least 3,000; and at least one hydrophilic vinyl-containing monomer, wherein the polymerizable composition has a molar ratio of total amount of mono-functional acrylate-containing siloxane monomer to total amount of bi-functional acrylate-containing siloxane monomer of at least 30:1, respectively.

Abstract: Apparatus and a method for using a packaging system for a sterilizable item. The packaging system includes a first sleeve that is elongated and a second sleeve that encloses one end of the first sleeve. The first sleeve is an elongated open ended tube or pouch. The second sleeve is an open ended tube or pocket. The sides of the first sleeve and the sides of the second sleeve are proximate each other with the closed end of the first sleeve proximate a closed end of the second sleeve. The open end of the first sleeve is folded into a cuff that covers the open end of the second sleeve. In one embodiment, the apparatus includes a sterilization indicator affixed to the outside of the packaging system.

Abstract: A method of making a packaged antimicrobial suture comprising the steps of providing a containment compartment that is substantially free of an antimicrobial agent; positioning a suture within the containment compartment, said suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; placing the containment compartment having the suture in an outer package; and subjecting the outer package, the containment compartment and the suture to time, temperature and pressure conditions sufficient to transfer an effective amount of the antimicrobial agent from the suture to the containment compartment, while retaining an effective amount of said antimicrobial agent on the suture, thereby substantially inhibiting bacterial colonization on the suture and the containment compartment.

Abstract: The invention relates to protected filter units for safety filtration, in which the filter units are at least double-packed with different packaging materials and to a method for producing the protected filter units. In this case, the first packaging material is permeable to gases but impermeable to microorganisms and the at least second packaging material is impermeable to gases. The first packaging material fixes the at least one filter unit, and so no abrasion can take place during transport and handling. The filter units according to the invention are suitable for sterile filtration processes and for filtration processes under clean-mom conditions.

Abstract: A method and means for handling of laboratory animal drinking bottles (17) provided with nipples (17) in an automatic bottle wash-up line, wherein the nipples (16) of all the bottles (17), arranged in a basket, are removed from the bottles with the aid of compressed air in a nipple removal means (2) and are washed and dried together with the drinking bottles and are subsequently put back onto filled bottles in a nipple reassembly means (4), which operates with similar tools (6) as the nipple removal means (2).

Abstract: A method of sterilizing an article is provided. The method includes providing sterilization wrap system with which to wrap the article to be sterilized. The sterilization wrap system comprises a plurality of wrap units configured in a stack, at least one wrap unit in the stack being detachably attached to at least one other wrap unit in the stack.

Abstract: A method and a device for the aseptic filling of a liquid food product that contains at least one solid particle, including disinfection with a disinfection unit of at least a part of the external surface of at least one first container which contains the solid particle, and disinfection of at least a second container, opening of the disinfected first container with an opening unit and removal of the solid particle, and filling via a filling unit of a disinfected second container with the solid particle and a liquid food.

Abstract: There are provided a packaging bag, which allows visual confirmation of the content yet does not bleach medical supplies contained therein, a packaging bag containing medical supplies, and a packaging method for medical supplies. A packaging bag 10 of the present invention includes two front and back films 11 and 12, at least one of which is transparent and are bacteria impermeable and do not transmit molecules as large as or greater than O2, wherein a material 13 that is gas permeable and bacteria impermeable is extended on the opening side of at least one of the films, and the periphery of the front and back films except for the opening is sealed. Medical supplies 15 are contained in the packaging bag 10, the opening is sealed to form a seal part 16b, and sterilization processing using EO gas or the like is executed. The EO gas is then removed and it is sealed by a seal part 16c. Even if the medical supplies 15 are exposed to an antiseptic solution such as H2O2, it will not enter the packaging bag 10.

Abstract: A method for producing contents filled in a container comprising steps of introducing a polyester container with a non-crystallized neck portion into a sterilized closed space having sterility and closed state on a commercial basis and comprising at least space in which a bottle sterilizing process is performed, space in which a filling process is performed and space in which a sealing process is performed, entire inner surface of said sterilized closed space and surface of an apparatus disposed in said sterilized closed space being sterilized by wet heating of the space using heated water and/or steam, at least the space in which the filling process is performed and the space in which the sealing process is performed being kept under a positive pressure by sterilized air; heating and sterilizing the container at least in its inner surface by wet heating using hot water and/or steam; and filling the contents in the sterilized container at a filling temperature within a temperature range from 40° C.

Abstract: Apparatus for molding and filling a device having a body defining an opening in communication with an interior chamber for receiving a substance therein, and a closure including a penetrable and resealable portion for sealing the opening and substance received in the device. A mold includes within the aseptic chamber plural mold cavities shaped to form the closure and body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the body and closure is movable relative to the mold to engage and de-mold the substantially sterile closures and bodies from the mold cavities. Flexible barriers are coupled to the mold and the tool to substantially prevent the passage of contaminants from the molding machine and tool therethrough.

Abstract: The packing according to the invention comprises: a container for holding said at least one object to be sterilized, having an inlet opening and a discharge opening via which said at least one object may pass into and out of said container, said container comprising a rigid part which comprises a peripheral wall bored with a multitude of small holes having dimensions smaller than those of the said at least one object, and a non-rigid part in a material porous to the sterilization fluid and non-porous to microbial contamination, this non-rigid part being able to contain said rigid part and to be sealed thereon; and at least one envelope made in a flexible and airtight material, which is vacuum sealing fitted on said container.

Abstract: Machine for manufacturing flexible sheet material packagings, including an area for feeding a continuous web of flexible sheet material, a preforming area including an area for folding a bottom wall of the packaging, a welding area, an area for filling the packagings, an area for outputting the packagings, a first chemical decontamination treatment area using a gas, arranged between the preforming area and the filling area, and an outside chamber that surrounds the machine at least partially and is depressed atmospherically with respect to the first area. The outside chamber acts as an additional barrier between the first area and the outside.

Abstract: Package for a catheter, with a catheter having catheter tube with a distal end and a proximal end, the proximal end being provided with a catheter connector. A main body is provided for holding the catheter, and a cap for closing off the main body. A gel container is positioned inside the main body, the gel container being provided with a cavity for holding an amount of gel-like lubricating agent. The gel container includes a first opening at a distal end thereof, and a second opening at a proximal end thereof.

Abstract: Machine (10) and method for treating containers (12) of liquids comprising a loading station (15) into which baskets (23) are loaded containing, according to a desired pattern of disposition, the containers (12) to be subjected to washing, a filling station (18) in which the washed containers (12) are filled with new liquid, and a re-closing station (19) in which the containers (12) are closed by the relative lids (11). The re-closing station (19) comprises a closing device (63) provided with gripper members (70) by means of which the lids (11) are picked up and positioned so as to close the containers (12), and loading members (66) that automatically direct the lids (11) toward the closing device (63) in a manner consistent with the desired pattern of disposition of the containers (12) in the baskets (23).

Abstract: A system and method of producing sterile beverages and containers, e.g., cleaning, sterilizing, and pre-sterilizing the bottles, the caps, and the critical surfaces using electrolyzed water. The sterilization system may include a mechanical sprayer that sprays electrolyzed water on the bottles, the caps, and the critical surfaces. In another embodiment, the sterilization system may include a fog generator connected to an electrolyzed water generator that produces a fog within a closed sterilization enclosure to sterilize the bottles, the caps, and the critical surfaces. Additionally, further, in yet another embodiment, the sterilization system may include an electrostatic fog generator connected to an electrolyzed water generator that produces an electrostatic, positively-charged fog within a closed sterilization enclosure.

Abstract: A method is provided for implanting a valve having at least one valve leaflet within the cardiovascular system of a subject. One step of the method includes preparing a substantially dehydrated bioprosthetic valve and then providing an expandable support member having oppositely disposed first and second ends and a main body portion extending between the ends. Next, the substantially dehydrated bioprosthetic valve is attached to the expandable support member so that the substantially dehydrated bioprosthetic valve is operably secured within the main body portion of the expandable support member. The expandable support member is then crimped into a compressed configuration and placed at a desired location within the cardiovascular system of the subject. Either before or after placement at the desired location, fluid or blood re-hydrates the substantially dehydrated bioprosthetic valve.

Abstract: A beverage bottling plant for filling beverage bottles with a beverage bottle treatment machine and a beverage bottle treatment machine in a beverage bottling plant. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. §1.72(b). As stated in 37 C.F.R. §1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.”The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.

Abstract: A method of making a packaged antimicrobial suture comprising the steps of providing a containment compartment that is substantially free of an antimicrobial agent; positioning a suture within the containment compartment, said suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; placing the containment compartment having the suture in an outer package; and subjecting the outer package, the containment compartment and the suture to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the suture to the containment compartment, while retaining an effective amount of said antimicrobial agent on the suture, thereby substantially inhibiting bacterial colonization on the suture and the containment compartment.

Abstract: A multi-container transfer and delivery device configured to allow multiple containers to transfer and mix their respective materials and for receiving of the mixed materials to a delivery device. The transfer device comprises a plurality of flow conduits for fluid flow between the multiple containers and the delivery device. Methods of mixing using the device and methods of sterilizing the device are described. A drug mixing kit comprising a multi-container housing with a plurality of flow conduits and a plurality of compartments for receiving containers and a transfer device is also described.

Abstract: A method of treating at least one container in a container treatment plant, including marking at least one container with a marking, detecting the marking of the at least one container, selecting at least one container treatment machine of a container treatment plant and/or at least one operation setting of the at least one container treatment machine of the container treatment plant based on the detected marking, and treating the at least one container based on the selection of the at least one container treatment machine and/or the at least one operation setting.

Abstract: An injector (1) for folding and injecting into the eye of a patient a flexible intraocular lens, the injector comprising an assembly of an injection nozzle (202), a lens compartment that holds an unfolded flexible intraocular lens (400) and is in communication with the injection nozzle, an injector body (3) communicating with the lens compartment and a plunger (2) that is inserted in the free end of the injector body, wherein lens compartment and injector body comprise a mechanism whereby the lens is first folded by forces compressing the lens in a non-axial direction in response to an axial movement of the plunger over a first distance and is subsequently expelled from the injector through the injection nozzle in response to an axial movement of the plunger over a second distance.

Abstract: A lancet integrated test element tape includes a plurality of lancet integrated test elements. The lancet integrated test elements each include a lancet configured to form an incision in tissue and a test element configured to analyze body fluid from the incision in the tissue. A cartridge includes a supply compartment configured to store an unused section of the tape. The tape is folded within the supply compartment to limit damage to the lancet integrated test elements. The cartridge can further include a waste compartment in which a used section of the tape is stored. An indexing mechanism moves the tape between the supply and waste compartments.

Abstract: A flexible non-PVC, non-DEHP container or bag for medical fluids has a container body formed of a multiple layer polyolefin film. The container has one or more ports equipped with a polyolefin fill tube and port closure assembly. The container has a low moisture vapor transmission rate.

Abstract: This application is directed toward an improved method of synthesizing cationic siloxane prepolymers as well as a specific cationic siloxane prepolymer having improved compatibility with monofunctional siloxanyl methacrylate monomers and medical devices containing the cationic siloxane prepolymer.

Abstract: A method and an apparatus for hot-fill or cold fill sterilization of a container containing both a liquid and solid inclusions. The method and apparatus each prevent the inclusions from agglomerating in any area of the container, such as the container closure, thus allowing the liquid to contact the interior surfaces of the container for a time sufficient to achieve sterilization of the entire container. The filled container is subjected to an inversion sequence typically including alternating between inverting the container to an angle of about 60 degrees from vertical and an angle of about 140 degrees from vertical, over a time period of at least 30 seconds. The apparatus includes a means for conveying containers, configured to subject the containers to a series of angles as the containers are conveyed, as well as an enclosure for preventing the containers from falling off of the conveying means.

Abstract: An apparatus for sterile filling of beverage containers has a first module and a second module. The first module rinses and sterilizes empty containers and delivers the sterilized containers to the second module. The second module fills and caps the containers with beverage product at ambient temperature in an active sterilization zone utilizing an e-beam sterilization unit.

Abstract: A sterile device immersed in a sterile buffer and a method for providing same. The sterile device may be a medical device such as a biosensor having a biomolecule as a sensing element such as, for example, a glucose oxidase enzyme. The buffer may be a bicarbonate solution. Both the device and the buffer may be packaged and stored over long term while maintaining sterilization. The sterilization method may comprise a combination of gaseous, liquid and light sterilization.

Abstract: Described herein is a germ guard label and methods of using the same. A germ guard label at least substantially conformal to an oral transmission area of an object can prevent or limit transmission of contaminants like germs, for example, from person to person. When an infected person touches an object covered with a germ guard label, germs transmitted from the infected person can contaminate the germ guard label rather than the object. Another person can remove the contaminated germ guard label from the object, and the oral contact area of the object covered by the germ guard label can be substantially germ free. The germ guard label also can prevent spillage of a substance from the oral contact area.

Abstract: A method of sterilising items by placing items to be sterilised into a puncture resistant sealable vapour barrier sterilisation bag, performing steam sterilisation under pressure via a conduit coupled to the bag whilst maintaining a heated compensating pressure environment around the exterior of the bag during steam sterilisation so as to reduce mechanical stress on the bag and sealing the bag at the completion of sterilisation. There is also provided a sterilisation services apparatus for sterilising the contents of a sterilisation bag including a pressure compensating compartment having a sealable door that maintains a heated compensating pressure environment around the exterior of a sterilisation bag during steam sterilisation so as to reduce mechanical stress on the bag.

Abstract: The silicone rubber composition disclosed here is formed a configuration in which vitamin E or a derivative thereof, or a salt of any one thereof is dispersed at least at a portion of the silicone rubber. Also disclosed is a method of manufacturing a medical apparatus that involves mixing a silicone rubber precursor with vitamin E or a derivative thereof, or a salt of any one thereof and hardening the obtained mixture, or a process of infiltrating a silicone rubber into vitamin E or a derivative thereof, or a salt of any one thereof in a liquid state. Further, the method of manufacturing a medical apparatus as disclosed here includes installing the obtained silicone rubber composition onto a medical apparatus; hermetically packaging the obtained medical apparatus; and irradiating radiation to the hermetically packaged medical apparatus.

Abstract: An oral pouch product made from cotton material and filled with coffee beans. The oral pouch is placed in a user's mouth and is chewed to scrub odor-causing bacteria from the user's mouth. A method for manufacturing and using an oral pouch containing coffee beans where the oral pouch scrubs odor-causing bacteria from a user's mouth.

Abstract: A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.

Abstract: Described herein is a cost-effective and time-efficient method for making UV-absorbing contact lenses. In contrast to the conventional method for making UV-absorbing contact lenses which involves copolymerizing a lens forming composition including a UV-absorbing vinylic monomer, a method of the invention involves covalent attachment of a UV-absorbing compound having a second reactive functional group to a preformed contact lens having a first reactive functional group therein and/or thereon.

Abstract: Provided is an aseptic filling packaging machine that includes film feeder (1), plug feeder (2), welding devices (22, and 55), sterilizer (3), and filling packaging device (5). Film feeder (1) feeds strip film (8). Plug feeder (2) feeds plug (7) to a predetermined position of fed film (8). Primary welding mechanism (22), which serves as a welding device, temporarily welds plug (7) to the predetermined position of film (8). Sterilizer (3) immerses film 8 having plug (7), which has been fed from film feeder (1), in a sterile liquid. While forming film 8 having plug (7), which has been fed from sterilizer (3), into a bag shape, filling packaging device (5) fills the formed film packaging body having the plug with content to seal it. In filling packaging device (5), secondary welding mechanism (55) that serves as a welding device completely welds plug (7) to film (8).

Abstract: The invention concerns a peel-off package for sterilization.

Abstract: A system for reducing pathogens for food in packaging comprises a bagger and pathogen reducer. The bagger is for inserting a food item into a package. The pathogen reducer is for reducing pathogens by exposing the food item and the package with the food item inside using infrared energy.

Abstract: The disclosure includes systems and methods for hospital based sterilization of surgical instruments. An exemplary system includes a wrapped sterilization tray or container defining at least one opening to permit a sterilant to pass therethrough and least one surgical instrument disposed in the sterilization tray. The system still further includes a count sheet holder disposed on the sterilization wrap or container. The count sheet holder defines a compartment for receiving a count sheet and means for attaching the count sheet holder to the sterilization container or wrapped tray.

Abstract: An apparatus for sterilizing various articles includes a cabinet defining a chamber and having a door coupled to the cabinet for selectively sealing the chamber in an airtight manner. The apparatus includes a vacuum pump in communication with the chamber for withdrawing air from the chamber and any respective article placed therein, e.g. a pillow, the vacuum pump causing a reduced air pressure within the chamber. The apparatus further includes an ozone generator in communication with the chamber for introducing ozone into the chamber and into any respective article placed therein. Still further, the apparatus includes an ozone filter in communication with the chamber and having a non-consumable catalyst for converting the ozone into oxygen.

Abstract: An integrated disposable includes a test strip and a lancet packet coupled to the test strip. The lancet packet includes a sterility sheet enclosing at least a portion of a lancet to maintain the sterility of the lancet. The lancet packet and the sterility sheet, in particular, allow the lancet to be sterilized separately from the test strip. The lancet in one form is incorporated into a lancet tape that is sterilized in a continuous, reel-to-reel sterilization process. The lancet tape in one form is sterilized using an electron beam sterilization process. With electron beam sterilization, sterilization is enhanced by irradiating both sides of the tape with electron beams. Sterilization can adversely affect chemical reagents in the test strip. To alleviate this chemistry degradation issue, the lancet packet is attached to the test strip after the lancet is sterilized.

Abstract: The invention relates to a method for testing a sterilization packaging unit provided for sterilization of objects to be sterilized, in particular medical objects to be sterilized, for its efficacy against microbial recontamination of the sterilized objects after they have been sterilized. In accordance with the invention the packaging unit is charged with nutrient medium, subjected to a sterilization process and then stored for a period of time under ambient conditions. The packaging unit is then kept under conditions in which microbes multiply for cultivation of microbes which are present in or on the nutrient medium. The packaging unit is then opened and microbes, which have multiplied in or on the nutrient medium, are observed. The method permits the efficacy of the packaging unit with respect to its recontamination protection to be tested easily and reliably.

Abstract: Methods and systems for reduced temperature radiation sterilization of stents are disclosed.

Abstract: A method of sterilizing a packaging material for, for example, a ready-to-fill package with extended shelf-life for a food involves bringing a sterilization agent containing hydrogen peroxide into contact with the packaging material in order to remove microorganisms present on the packaging material. After the contact with the sterilization agent, the packaging material is ventilated with air so as to remove remaining residues of hydrogen peroxide on and/or in the packaging material. The removal of the remaining residues of hydrogen peroxide is improved synergistically by exposing the packaging material, after contact with the sterilization agent but before ventilation, to accelerated electrons at a kinetic energy of at least 50 keV.

Abstract: The packing according to the invention comprises: a first part, made of flexible and airtight material, defining a first portion and a second portion contiguous to the first portion, said first portion being separated from the second portion by an area suitable to be folded; at least one second part, made of a material porous to the sterilizing fluid, forming a pocket for the reception of the at least one object to be sterilized, said second part being connected to said first portion of said first part and being dimensioned so that its edges are, when said second part is connected to said first portion, set back of the edges of said first portion so as to define side assembly areas on said first portion; and airtight connection means for the connection of said second portion to said first portion in said side assembly areas.

Abstract: This invention provides a process of sterilizing a medical device, and preferably the contents of a sealed container which comprises said medical device, comprising the step of exposing said medical device to monochromatic ultraviolet radiation whereby the Dvalue of Bacillus stearothermophilus (ATCC 7953) is at least 23.7 mJ/cm2 monochromatic ultraviolet radiation at 257 nm to the spore. Further, this invention provides a process of sterilizing a medical device comprising the step of subjecting said medical device to monochromatic ultraviolet radiation wherein the minimum total energy density of said monochromatic ultraviolet radiation at 257 nm which reaches the microorganisms present on said medical device is at least 284 mJ/cm2. This invention further provides an apparatus for delivering UV radiation to a medical device for sterilization comprising a laser and a scanner for the laser such that at least 284 mJ/cm2 at 257 nm is applied to a treatment area for said medical device.

Abstract: The present invention relates to a coextruded multilayer polyolefin film, said polyolefin film being substantially curl-free in use, said polyolefin film comprising: a polyolefinic base layer comprising between 10% and 50% by weight of a cyclic olefin copolymer having a Tg higher than 130° C.; a polyolefinic sealing layer having a thickness between 5 and 15% of the total film thickness.

Abstract: Methods of sterilizing medical devices, including implantable medical devices like stents, chemically and with radiation are disclosed. Methods of preparing a sterile, packaged medical device, including a sterile, packaged implantable medical device or stent are disclosed.