Dextrin Or Derivative Patents (Class 536/103)
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Publication number: 20130011364Abstract: The present invention relates to polymers imprinted by retention solutes, use of same as well as compositions containing same.Type: ApplicationFiled: March 18, 2011Publication date: January 10, 2013Inventors: Thomas Fichert, Ingo Bichlmaier
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Publication number: 20130012613Abstract: A method synthesizes a composition of polymers, copolymers, terpolymers and tetrapolymers. The composition may be made by combining in a reaction chamber, a crosslinking agent and one or more of a calix[n]arene, cyclodextrin, a mixture of a plurality of calix[n]arenes, different cyclodextrins, derivatives of calix[n]arenes, and derivatives of cyclodextrins, stirring the mixture, making a solid residue using microwaves, washing the solid residue, drying some of the wash, filtering some of the wash, and drying the resulting filtered solution. The composition may include alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, the derivatives or corresponding mixtures thereof, and/or calix[n]arene(s) and/or of calix[n]arene derivative(s) and/or a mixture of two or more different calix[n]arenes selected from calix[n]arenes (n=4-20) and/or the derivatives thereof.Type: ApplicationFiled: December 27, 2010Publication date: January 10, 2013Inventor: Mohamed Skiba
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Publication number: 20130005684Abstract: The present invention relates to cyclodextrin copolymers, processes for preparing same and their use to prepare pharmaceutical compositions.Type: ApplicationFiled: March 18, 2011Publication date: January 3, 2013Inventors: Thomas Fichert, Ingo Bichlmaier
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Publication number: 20130005834Abstract: The present invention relates to pharmaceutical compositions containing substituted 6-deoxy-6-sulfanylcyclodextrins as well as their use as osmotic agents, in particular for use in dialysis therapy.Type: ApplicationFiled: March 18, 2011Publication date: January 3, 2013Inventors: Thomas Fichert, Johannes Gerber, Ingo Bichlmaier
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Publication number: 20120316332Abstract: An object of the present invention is to provide novel dextrin fatty acid ester that is excellent in tackiness and useful as a base for cosmetics and the like. The novel dextrin fatty acid ester is prepared by esterification between dextrin and fatty acids, wherein the dextrin has an average degree of glucose polymerization of 3 to 150; the fatty acids comprise more than 50 mol % and 100 mol % or less, based on the total amount of the fatty acids, of one or more saturated branched fatty acids having 4 to 26 carbon atoms, and 0 mol % or more and less than 50 mol %, based on the total amount of the fatty acids, of one or more fatty acids selected from the group consisting of saturated linear fatty acids having 2 to 22 carbon atoms, unsaturated linear or branched fatty acids having 6 to 30 carbon atoms, and saturated or unsaturated cyclic fatty acids having 6 to 30 carbon atoms; and the degree of substitution by the fatty acids is 1.0 to 3.0 per glucose unit.Type: ApplicationFiled: February 16, 2011Publication date: December 13, 2012Applicants: KOSE CORPORATION, CHIBA FLOUR MILLING CO. LTD.Inventors: Hideaki Koike, Takanao Suzuki, Daisuke Tsukioka, Satsuki Miyagawa, Yuriko Tomita, Keiji Igarashi
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Patent number: 8314230Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: GrantFiled: October 20, 2011Date of Patent: November 20, 2012Assignee: Cerulean Pharma Inc.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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Patent number: 8293723Abstract: Inclusion compounds consisting of certain Angiotensin II AT1 receptors antagonist and cyclodextrins are described. These inclusion compounds are useful in the treatment of hypertension.Type: GrantFiled: December 23, 2010Date of Patent: October 23, 2012Assignee: Universidade Federal de Minas GeraisInventors: Ruben Dario Sinisterra Millan, Robson Augusto Souza Dos Santos, Frederic Jean Georges Frezard, Washington Xavier De Paula
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Publication number: 20120259108Abstract: The invention relates to a safely handleable and transportable composition including an alpha-cyclodextrin-chlorine dioxide complex and an inert substance, and also a method for production thereof.Type: ApplicationFiled: March 21, 2012Publication date: October 11, 2012Applicant: WACKER CHEMIE AGInventors: Benno KRUEGER, Gerald FLEISCHMANN, Stefan NEUMANN
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Patent number: 8278437Abstract: Hydroxypropyl-sulfobutyl-&bgr;-cyclodextrin, the preparation method, analytical method, and the pharmaceutical application thereof. The hydroxypropyl-sulfobutyl-&bgr;-cyclodextrin is a derivate of cyclodextrin which is substituted by hydroxypropyl group and sulfobutyl group: n-(2,3,6-O-2-hydroxypropyl)-m-(2,3,6-O-sulfobutyl)-&bgr;-cyclodextrin. The number of substituent groups per mole cyclodextrin is n hydroxypropyl groups and m sulfobutyl groups. “n” represents the average substituent degree of hydroxypropyl groups; “m” represents the average substituent degree of sulfobutyl groups; “n+m=z” is the gross average substituent degree, in which n is a random integer chosen from 1,2,3,4,5,6,7,8,9; m is a random integer chosen from 1,2,3,4,5,6,7,8,9; and the gross average substituent degree z is a random integer chosen from 2,3,4,5,6,7,8,9,10. The present invention shows low haemolysis and low toxicity.Type: GrantFiled: November 28, 2005Date of Patent: October 2, 2012Assignee: Hainan Hdeton Science and Technology Co. Ltd.Inventors: Yong Ren, Xueqin Ma, Shuqin Yu, Xiaodong Sun
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Patent number: 8268017Abstract: Provided are a method of stabilizing a leuco dye storable as a liquid for a long time, a method of reducing nonspecific color development thereof at a time of a color development reaction, and a stable liquid reagent composition using the methods. The inventors of the present invention found that coexistence of the leuco dye with a specific reducing agent resulted in suppression of self color development and its remarkably improved stability in a solution, and that when a color development reaction of the leuco dye with hydrogen peroxide was performed, coexistence of the leuco dye, in a reaction solution, with another dye which had an absorption spectrum not influencing a measurement wavelength of the leuco dye and did not react with hydrogen peroxide suppressed nonspecific color development and lowered a reagent blank value, which was applied to an analytical reagent.Type: GrantFiled: February 21, 2008Date of Patent: September 18, 2012Assignee: Asahi Kasei Pharma CorporationInventors: Shigeru Ueda, Takeshi Matsuoka, Akihiko Kan
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Publication number: 20120208897Abstract: The present invention relates to a continuous method for preparing acetylated derivatives of an amylaceous material. The invention also relates to a solid composition of at least one acetylated derivative of an amylaceous material obtained by means of said method. The invention finally relates to the use of such a composition to prepare thermoplastic, elastomeric, adhesive, pharmaceutical and/or ink compositions.Type: ApplicationFiled: October 11, 2010Publication date: August 16, 2012Applicant: ROQUETTE FRERESInventor: Claude Quettier
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Publication number: 20120202773Abstract: A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).Type: ApplicationFiled: April 23, 2012Publication date: August 9, 2012Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Toru Maruyama, Kaoru Kobayashi, Tohru Kambe, Takayuki Maruyama, Hideyuki Yoshida, Akio Nishiura, Nobutaka Abe
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Publication number: 20120202772Abstract: Methods and compositions relating to CDP-proteasome inhibitor conjugates are described herein.Type: ApplicationFiled: April 17, 2012Publication date: August 9, 2012Inventors: Alexandra Glucksmann, Lawrence Alan Reiter, Thomas C. Crawford
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Publication number: 20120196831Abstract: There is provided a composition for preventing and treating obesity including high water-soluble ?-cyclodextrin derivatives as an effective component. Specifically, the composition including the high water-soluble ?-cyclodextrin derivatives, especially, 2-hydroxypropyl-?-cyclodextrin (HP-?-CD, HPBCD) has effects on suppressing an increase in body weight induced by a high fat diet, suppressing appetite through decreasing an amount of dietary intake, decreasing body fat, decreasing liver weight, and significantly decreasing a sharp increase of blood sugar induced by intaking glucose and maltose on an empty stomach so that it can be useful for preventing and treating obesity, preventing and treating various diseases induced by obesity, and suppressing a sharp increase of blood sugar after dinner.Type: ApplicationFiled: October 8, 2010Publication date: August 2, 2012Applicant: SONG HO BIOMED CO., LTDInventors: Gyoon-Hee Han, Yong Seok Choi, Sang-Bae Han, Jong-Ho Lee, Hwan-Mook Kim, Song-Kyu Park, Ki-Ho Lee, Jong-Soon Kang, Ki-Hoon Lee, Chang-Woo Lee
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Patent number: 8222400Abstract: Disclosed is a cyclodextrin compound comprising glucopyranoses constituting cyclodextrin, the glucopyranoses having substituents each having folic acid substituted for two or more primary hydroxy groups at position-6 of the glucopyranoses.Type: GrantFiled: September 26, 2008Date of Patent: July 17, 2012Assignee: Nanodex Inc.Inventor: Kenjiro Hattori
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Publication number: 20120171184Abstract: A composition interacts with a biological cell system that includes bioactive molecules with biomolecular surfaces, cellular components and water molecules with a specific density. The composition includes a biologically active component that is constructed to increase an activity of a biological cell system by increasing the hydration of one or more components of that cell system. The biologically active component may include a primary carbohydrate clathrate subcomponent that increases the H-bonded structure of water, and a secondary solute subcomponent. The biologically active component may include an inclusion complex that is made up of a clathrate component and a complex-forming compound. The clathrate subcomponent may include amyloses or cyclodextrins. There is also a beverage and a method that improves cellular hydration in an animal, such as a human.Type: ApplicationFiled: December 31, 2010Publication date: July 5, 2012Inventor: Lajos SZENTE
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Patent number: 8202807Abstract: A reactive cyclodextrin derivative or a reactive glucose derivative is used as a template derivative for forming an ultra-low dielectric layer. A layer is formed of the reactive cyclodextrin derivative or the reactive glucose derivative capped with Si—H and then cured in an atmosphere of hydrogen peroxide to form the ultra-low dielectric layer.Type: GrantFiled: December 27, 2007Date of Patent: June 19, 2012Assignee: Hynix Semiconductor Inc.Inventors: Sung Kyu Min, Ja Chun Ku, Chan Bae Kim, Sang Tae Ahn, Chai O Chung, Hyeon Ju An, Hyo Seok Lee, Eun Jeong Kim
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Publication number: 20120148504Abstract: The present disclosure discloses a pharmaceutical molecule of Garcinol chemically complexed with cyclodextrins and the use of the complexed molecule in prevention and management of cardiac dysfunction induced by chemotherapy, drugs and/or other insults to the heart caused by lifestyle and disease conditions. The disclosure also relates to a method of extraction and purification of high yield of 95-99% pure Garcinol from Garcinia species and a method of chemically complexing Garcinol with cyclodextrins to improve its stability and bioavailability.Type: ApplicationFiled: January 28, 2011Publication date: June 14, 2012Applicant: INDUS BIOTECH PRIVATE LIMITEDInventors: Sunil Bhaskaran, Mohan Vishwaraman
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Publication number: 20120141590Abstract: Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.Type: ApplicationFiled: September 30, 2011Publication date: June 7, 2012Inventors: Michael Malakhov, Fang Fang
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Publication number: 20120136072Abstract: A particulate SAE-CD composition is provided. The SAE-CD composition has an advantageous combination of physical properties not found in known solid forms of SAE-CD. In particular, the SAE-CD composition possesses an advantageous physicochemical and morphological property profile such that it can be tailored to particular uses. The SAE-CD composition of the invention has improved flow and dissolution performance as compared to known compositions of SAE-CD.Type: ApplicationFiled: September 23, 2011Publication date: May 31, 2012Inventors: Gerold L. Mosher, James D. Pipkin, Douglas B. Hecker
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Publication number: 20120107477Abstract: The present invention relates to inclusion products containing or consisting of one or a plurality of flavoring materials and a maltodextrin fraction. Moreover, a production process for said inclusion products is provided according to the invention. The invention further relates to maltodextrin fractions, in particular those that are suitable for preparing inclusion products according to the invention, and corresponding use of maltodextrin fractions according to the invention.Type: ApplicationFiled: November 2, 2011Publication date: May 3, 2012Applicant: SYMRISE AGInventor: Sven Siegel
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Patent number: 8168778Abstract: An object of the present invention is to provide a novel starchy substance having a retrogradation-resistance, a process for producing the starchy substance efficiently from a material starch by enzymatic reaction, and uses thereof. The present invention attains the above object by providing branched starch having 6-?-maltosyl- and/or 6-?-maltotetraosyl-structure(s) with a marked retrogradation-resistance, a process for producing the branched starch without lowering the molecular weight of material starch, and uses thereof.Type: GrantFiled: March 14, 2006Date of Patent: May 1, 2012Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Tomoyuki Nishimoto, Katsuhiko Hino, Takanori Okura, Hiroto Chaen, Shigeharu Fukuda, Toshio Miyake
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Patent number: 8158610Abstract: A method of reducing the incidence of post-operative adhesions in or associated with a body cavity, which comprises introducing into the body cavity a composition containing an aqueous solution or suspension or gel formulation containing the polysaccharide dextrin.Type: GrantFiled: May 7, 2010Date of Patent: April 17, 2012Assignee: Innovata LimitedInventor: Colin Brown
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COMPOUND HAVING DETRUSOR MUSCLE-CONTRACTING ACTIVITY AND URETHRAL SPHINCTER MUSCLE-RELAXING ACTIVITY
Publication number: 20120088805Abstract: Since a compound represented by formula (I) wherein all of the symbols are the same as defined in the specification, a salt thereof, a solvate thereof, a prodrug thereof, a mixture with a diastereomer thereof in an arbitrary ratio, or a cyclodextrin clathrate thereof have a contracting activity of bladder detrusor and a relaxing activity of urethral sphincter, they can ameliorate bladder contraction dysfunction and/or urethral relaxation dysfunction, and for example, are effective for underactive bladder. Additionally, the compound of the present invention has little risk of side effects on the urinary system, the circulatory system and the digestive system, and exhibits excellent pharmacokinetics, such as oral absorbability etc. Therefore, the compound of the present invention is useful as a superior agent for preventing, treating and/or ameliorating underactive bladder.Type: ApplicationFiled: June 9, 2010Publication date: April 12, 2012Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Kazuyuki Ohmoto, Akihiro Kinoshita, Hidekazu Matsuta, Hiroki Okada -
Publication number: 20120077774Abstract: The invention is directed to compositions that function to remove cholesterol from a mammal suffering from an elevated cholesterol level. The composition includes a polysaccharide having attached thereto at least one cyclic oligosaccharide. In a particular embodiment, the foregoing composition further includes at least one cell-targeting agent. The invention is also directed to methods that utilize these compositions for removing or reducing cholesterol and other lipids in a mammal suffering from an elevated level of cholesterol and/or other lipid.Type: ApplicationFiled: May 28, 2010Publication date: March 29, 2012Applicant: CORNELL UNIVERSITYInventors: Frederick Maxfield, J. David Warren
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Publication number: 20120077970Abstract: A method for preparing molecular complexes between Adapalene and cyclodextrins using the technology of dense fluids under pressure, especially that of CO2 is described.Type: ApplicationFiled: April 9, 2010Publication date: March 29, 2012Applicant: Galderma Research & DevelopmentInventors: Hubert Lochard, Bernard Freiss
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Patent number: 8142812Abstract: A formulation, especially a pharmaceutical formulation, comprises an active agent and a carrier for the active agent, wherein the carrier comprises a beta-limit dextrin. The formulation may be a bioadhesive pharmaceutical formulation in which the beta-limit dextrin acts as a mucoadhesive agent. The active agent is a pharmaceutically active agent or a flavour or fragrance which is intended for delivery into the buccal cavity. A use of beta-limit dextrin as a disintegrant, a dispersant, and a mucoadhesive agent is also described. Also described is a nutritional product such as an energy drink which includes beta-limit dextrin as an energy source.Type: GrantFiled: July 29, 2003Date of Patent: March 27, 2012Assignee: Glycologic LimitedInventors: Richard Frank Tester, Xin Qi
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Publication number: 20120070492Abstract: The invention relates to pharmaceutical compositions comprising rhein or diacerein or salts or esters or prodrugs thereof, optionally with one or more pharmaceutically acceptable excipients. The invention also relates to the methods for preparing such compositions.Type: ApplicationFiled: September 13, 2008Publication date: March 22, 2012Inventors: Rahul Dabre, Girish Kumar Jain, Cyril Estanove, François Pruvost, Roshanlal Sandal, Prashant Mandaogade, Premchand Nakhat
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Publication number: 20120070904Abstract: Disclosed are cyclodextrin-based metal organic frameworks comprising a metal cation and cyclodextrin or a cyclodextrin derivative. These metal organic frameworks are permanently porous and capable of molecule storage.Type: ApplicationFiled: March 17, 2011Publication date: March 22, 2012Inventors: J. Fraser Stoddart, Ross S. Forgan, Ronald A. Smaldone, Jeremiah J. Gassensmith
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Publication number: 20120065161Abstract: Methods and compositions relating to CDP-epothilone conjugates are described herein.Type: ApplicationFiled: August 12, 2011Publication date: March 15, 2012Applicant: CERULEAN PHARMA INC.Inventor: John Ryan
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Publication number: 20120035355Abstract: Bleached dextrin compositions, methods of forming the same, and products formed therefrom. The composition comprises a dextrin-based composition or slurry, a caustic agent, and an oxidant. The caustic agent may include sodium hydroxide. The oxidant may include hydrogen peroxide.Type: ApplicationFiled: April 12, 2010Publication date: February 9, 2012Inventor: Normand Germain
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Publication number: 20120010166Abstract: The invention relates to an iron oligosaccharide compound with improved stability comprising a hydrogenated oligosaccharide in stable association with ferric oxyhydroxide, the content of dimer saccharide in said hydrogenated oligosaccharide being 2.9% by weight or less, based on the total weight of the hydrogenated oligosaccharide. In further aspects is provided a process for preparing said compound as well as the use of said compound for preparation of a composition for treatment of iron deficiency anaemia.Type: ApplicationFiled: March 25, 2009Publication date: January 12, 2012Applicant: Pharmacosmos Holding A/SInventor: Hans Andreasen
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Patent number: 8093375Abstract: A reactive polysaccharide derivative of formula, [Z1—B—SO2—CH2—CH2—O]n—PS—[OH]m (1), wherein 8 is a radical of formula (2a), (2b), (2c), (2d) or (2e), Z, is a reactive radical, and PS is a cyclodextrin, is useful as a finishing agent for textile fibers and for other applications.Type: GrantFiled: August 10, 2005Date of Patent: January 10, 2012Assignee: BASF SE LudwigshafenInventors: Philippe Ouziel, Torsten Kulke
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Publication number: 20110305685Abstract: A supramolecular approach has been developed for preparation of size-controllable nanoparticles, from three different molecular building blocks.Type: ApplicationFiled: February 26, 2010Publication date: December 15, 2011Applicant: The Regents of the University of CaliforniaInventors: Hsian-Rong Tseng, Hao Wang, Shutao Wang, Helen Su, Caius G. Radu, Johannes Czernin
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Publication number: 20110288049Abstract: Certain exemplary embodiments can provide a composition of matter comprising a solid form of chlorine dioxide complexed with a cyclodextrin. The concentration of chlorine dioxide in said solid form is greater than approximately 5.8 percent by weight. Certain exemplary embodiments can provide a method comprising forming a solid complex comprising chlorine dioxide and cyclodextrin, wherein a concentration of chlorine dioxide in the solid complex is greater than 5.8 percent by weight.Type: ApplicationFiled: May 19, 2011Publication date: November 24, 2011Inventors: Nick Blandford, Ken Harrison
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Publication number: 20110288055Abstract: This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds, and methods and uses reliant on said compounds. The exemplified compounds are all mitoquinone derivatives, being methoxyphenyl alkyl triphenylphosphonium or methoxy dioxocyclohexadiene alkyl triphenylphosphonium derivatives. The compounds, compositions, dosage forms, uses and methods are useful in, for example, the treatment of diseases or conditions associated with oxidative stress.Type: ApplicationFiled: January 5, 2011Publication date: November 24, 2011Inventors: Kenneth Martin Taylor, Robin A.J. Smith
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Publication number: 20110271372Abstract: According to the invention, there is provided seed and plants of the corn variety designated CV108997. The invention thus relates to the plants, seeds and tissue cultures of the variety CV108997, and to methods for producing a corn plant produced by crossing a corn plant of variety CV108997 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV108997 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV108997.Type: ApplicationFiled: April 30, 2010Publication date: November 3, 2011Inventor: Daniel Lubich
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Patent number: 8049003Abstract: A particulate SAE-CD composition is provided. The SAE-CD composition has an advantageous combination of physical properties not found in known solid forms of SAE-CD. In particular, the SAE-CD composition possesses an advantageous physicochemical and morphological property profile such that it can be tailored to particular uses. The SAE-CD composition of the invention has improved flow and dissolution performance as compared to known compositions of SAE-CD.Type: GrantFiled: April 23, 2008Date of Patent: November 1, 2011Assignee: CyDex Pharmaceuticals, Inc.Inventors: Gerold L. Mosher, James D. Pipkin, Douglas B. Hecker
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Publication number: 20110262614Abstract: An object of the present invention is to provide a material containing a saponin wherein the bitterness peculiar to saponin is effectively suppressed. According to the present invention, a saponin, a phytosterol and/or a phytosterol ester, and a cyclodextrin are mixed to form a complex, so as to suppress bitterness. The complex of the present invention can be formed in the presence of water by mixing a saponin, a phytosterol and/or a phytosterol ester, and a cyclodextrin. The complex of the present invention can be contained in a composition such as a food or beverage.Type: ApplicationFiled: December 24, 2009Publication date: October 27, 2011Applicant: HOUSE FOODS CORPORATIONInventors: Tadashi Hamajima, Morihiro Aoyagi, Seiji Yahara, Kazunori Sonobe, Akiko Kamoi
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Publication number: 20110256104Abstract: The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent.Type: ApplicationFiled: May 13, 2011Publication date: October 20, 2011Applicants: CALANDO PHARMACEUTICALS, INC., CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Suzie Hwang Pun, Hector Gonzalez, Mark E. Davis, Nathalie Bellocq, Jianjun Cheng
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Publication number: 20110237540Abstract: Methods and compositions relating to CDP-taxane conjugates are described herein.Type: ApplicationFiled: November 23, 2010Publication date: September 29, 2011Inventors: Thomas C. Crawford, Oliver S. Fetzer, Lawrence Alan Reiter, Marc Wolfgang
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Publication number: 20110224168Abstract: A fat-binding composition contains an inclusion complex with a host molecule and a guest molecule. The guest molecule includes one or more amino acids, vitamins, flavorants or related compounds, rutin, betanin, derivatives thereof, and mixtures thereof. The fat-binding composition may be in the form of a tablet or powder, for example, and may be incorporated into a food or beverage product. If in the form of a powder or tablet, the composition may optionally contain a carbonation-forming component and may be dissolved in carbonated or non-carbonated water. The fat-binding composition may also be employed in a method for binding fat ingested by an animal which includes having the animal ingest the composition, or a food or beverage product containing the same.Type: ApplicationFiled: March 13, 2011Publication date: September 15, 2011Inventor: Lajos SZENTE
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Publication number: 20110218156Abstract: In accordance with the present invention, it has been discovered that the uptake of negatively charged entities into cells can be enhanced by noncovalently associating such charged entities with molecular entities comprising an amphiphilic core with positively charged arms, wherein a plurality of lipophilic (e.g., bile acid) moieties are covalently attached to the positively charged arms. The molecular entities form well defined stoichiometric complexes with negatively charged entities. Various compositions and methods for stabilizing anionic charged entities and for enhancing the cellular uptake of any anionic charged entities, e.g. double-stranded or hairpin nucleic acid, are provided.Type: ApplicationFiled: January 28, 2011Publication date: September 8, 2011Inventors: Alexander Chucholowski, Alisher Khasanov, Tingmin Wang, Tong Zhu
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Publication number: 20110218173Abstract: Inclusion complexes of pinocembrin with cyclodextrin or its derivatives and their preparation are provided. The inclusion complexes can be used to make drugs.Type: ApplicationFiled: November 11, 2008Publication date: September 8, 2011Inventors: Song Wu, Guanhua Du, Yan Qi, Mei Gao, Qingyun Yang, Hongmei Guang, Wei Li, Yuehua Wang, Yuanfeng Tong
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Publication number: 20110195161Abstract: Disclosed herein are inclusion complexes comprising a substantially pure terpene glycoside and at least one cyclodextrin, wherein the solubility of the inclusion complex is greater than the solubility of the substantially pure terpene glycoside alone. Also disclosed herein are beverage compositions comprising at least one inclusion complex. Further disclosed herein are methods of increasing the solubility of a substantially pure terpene glycoside, comprising combining a substantially pure terpene glycoside with at least one cyclodextrin to form at least one inclusion complex. Still further disclosed herein are methods for improving the taste of an orally ingestible composition and an inclusion complex comprising at least two substantially pure terpene glycoside and at least one cyclodextrin.Type: ApplicationFiled: February 8, 2011Publication date: August 11, 2011Inventors: Mani UPRETI, Indra PRAKASH, Youlung CHEN
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Publication number: 20110178288Abstract: There is disclosed a process for preparing liquid maltodextrin having a D.E. of about 5 to less than about 20. Also disclosed are liquid maltodextrins having a D.E. of about 9 to about 15.Type: ApplicationFiled: March 30, 2011Publication date: July 21, 2011Applicant: CARGILL, INCORPORATEDInventors: Francois DELEYN, Christopher Aiken, Frank Derez, David Mauro, Dirk Provoost, Marie-Odile Stalin, Bruno Vanhemelrijck
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Publication number: 20110172182Abstract: This invention relates to novel ?-cyclodextrin polysulfate compounds comprising from one to three 2-carboxyethyl substituents, and at least two sulfates groups per glucopyranose unit, which are useful as active ingredients for the treatment and/or prophylaxis of degenerative joint diseases, osteoarthritis, articular rheumatism, arthrosis or degenerative arthritis, or for the treatment of heparin-induced thrombocytopenia, or for cartilage repair or connective tissue repair.Type: ApplicationFiled: September 22, 2009Publication date: July 14, 2011Applicant: ARCARIOS B.V.Inventors: Dirk Elewaut, August Lodewijk Verbruggen
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Publication number: 20110143944Abstract: Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.Type: ApplicationFiled: December 13, 2010Publication date: June 16, 2011Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Mark E. Davis, Hector Gonzalez, Suzie (Sue Jean) Hwang
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Publication number: 20110129944Abstract: Disclosed is a water soluble nanocrystal having a core comprising at least one metal M1 selected from an element of subgroup IIb, subgroup VIIa, subgroup VI11a, subgroup 1b, subgroup IV, main group II or main group III of the periodic system of the elements (PSE), at least one element A selected from an element of the main group V or VI of the periodic system of the elements, wherein a capping reagent is attached to the surface of the core of the nanocrystal, and wherein the capping reagent forms a host guest complex with a water soluble host molecule.Type: ApplicationFiled: January 17, 2005Publication date: June 2, 2011Applicant: Agency for Science, Technology and ResearchInventors: Fuke Wang, Mingyong Han
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Publication number: 20110124103Abstract: The present invention is directed to a macrocyclic derivative which is formed by modification of a macrocycle. The invention further relates to assemblies formed by the self-assembly of such macrocyclic derivatives in aqueous solvent, and includes bilayer vesicles, micelles, monolayers, nanoparticles, colloidal assemblies and surface-coated assemblies.Type: ApplicationFiled: July 6, 2009Publication date: May 26, 2011Applicants: UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF, UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRInventors: Raphael Darcy, Caitriona O'driscoll