Sulfur Or Halogen Containing Patents (Class 536/122)
-
Patent number: 7741121Abstract: The present application is generally directed to microfluidic devices and methods for the achievement and assessment of chemical and radiochemical purity of (microfluidic) radio-synthesis products. More particularly, the current application relates to systems for purification and analysis of radiochemical products yielded by microfluidic synthesis devices.Type: GrantFiled: August 23, 2007Date of Patent: June 22, 2010Assignee: Siemens Medical Solutions USA, Inc.Inventors: Arkadij M Elizarov, Hartmuth C. Kolb, Jianzhong Zhang
-
Publication number: 20100152121Abstract: Methods of treating glioblastoma and pancreatic cancer are provided by the administration of a therapeutically effective amount of a iodo-hexose compound to a subject in need thereof. The subject disclosure includes methods of treating glioblastoma and pancreatic cancer comprising the administration of a therapeutically effective amount of a 2-deoxy-2-iodo-D-hexose compound including 2-deoxy-2-iodo-D-mannose, 2-deoxy-2-iodo-D-glucose, 2-deoxy-2-iodo-D-galactose, and/or 2-deoxy-2-iodo-D-talose to a subject in need thereof.Type: ApplicationFiled: October 19, 2009Publication date: June 17, 2010Inventors: Waldemar Priebe, Slawomir Szymanski, Izabela Fokt, Charles Conrad, Timothy Madden
-
Patent number: 7732596Abstract: The present invention provides nitrogen-containing fused cyclic derivatives represented by the following general formula or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications or obesity, in the formula one of R1 and R4 represents a group represented by the following general formula (S) (in which R5 and R6 represent H, OH, a halogen atom, etc.; Q represents an alkylene group etc.; and ring A represents an aryl group etc.), and the other represents H, OH, an amino group, etc.; R2 and R3 represent H, OH, an amino group, a halogen atom, and an optionally substituted alkyl group, etc.; A1 represents O, S, etc.Type: GrantFiled: March 3, 2005Date of Patent: June 8, 2010Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Nobuhiko Fushimi, Hideki Fujikura, Masayuki Isaji
-
Publication number: 20100113762Abstract: Methods and apparatus for facilitating the synthesis of compounds in a batch device are presented. Application of the batch type microfluidic devices to the synthesis of radiolabeled compounds is described. These methods and apparatus enable the selective introduction of multiple reagents via an enhanced rotary flow distribution valve through a single inlet port of the synthetic device. The sequential introduction of multiple reagents through a single inlet port allows an optimal delivery of highly concentrated reagents into the reactor and facilitates the synthesis of the desired products with a minimal loss of materials during transfers, which is critical to the synthesis of radiolabeled biomarkers.Type: ApplicationFiled: November 4, 2009Publication date: May 6, 2010Applicant: Siemens Medical Solutions USA, Inc.Inventors: Carroll Edward Ball, Arkadij M. Elizarov, Hartmuth C. Kolb, Reza Miraghaie, Jianzhong Zhang
-
Patent number: 7709463Abstract: The invention relates to a dose of 2.5 mg of the pentasaccharide methyl O-(2,3,4-tri-O-methyl-6-O-sulfo-?-D-glucopyranosyl)-(1?4)-O-(2,3-di-O-methyl-?-D-glucopyranosyl uronic acid)-(1?4)-O-(2,3,6-tri-O-sulfo-?-D-glucopyranosyl)-(1?4)-O-(2,3-di-O-methyl-?-L-idopyranosyl uronic acid)-(1?4)-2,3,6-tri-O-sulfo-?-D-glucopyranoside or a pharmaceutically acceptable salt thereof for use in therapy, in particular for the treatment of venous thromboembolic events in patients with deep venous thrombosis.Type: GrantFiled: January 23, 2003Date of Patent: May 4, 2010Assignee: Sanofi-AventisInventor: Ronald Gijsbertus Maria Van Amsterdam
-
Publication number: 20100105889Abstract: A process for the preparation of Pentosan polysulfate sodium comprising a step of purifying depolymerized crude Pentosan polysulfate sodium by filtration through NF membrane system.Type: ApplicationFiled: May 16, 2007Publication date: April 29, 2010Inventors: Pandurang Balwant Deshpande, Parvenkumar Luthra, Anand Kumar Pandey, Dinesh Jayntibhai Paghdar, Phani,Sharma,Gowthamaiah Vemavarapu Govardhana
-
Publication number: 20100084345Abstract: A method for the manufacture of an agarose separation gel: The method is characterized in comprising the steps of: i) providing a solution of agar, and ii) one, two or more substeps (ii.A, ii.B, ii.C etc) which each comprises desulphating thereby transforming agar to agarose having a degree of substitution of sulphate groups that is at most 75% of the degree of substitution of sulphate groups in native agar, iii) gelling the dissolved agar prior to step (ii) and/or securing so that the desulphated agar is in g form at least after one or more of the substeps of step (ii), and imperatively after step (ii). An agarose separation gel that exhibits a. a plurality of methoxy groups each of which are at the same position as in native agar and with a degree of substitution in the range of 1-100% of the degree of substitution of native agar, and b. sulphate groups with a degree of substitution which is <75% of the degree of substitution for sulphate groups in native agar.Type: ApplicationFiled: April 29, 2008Publication date: April 8, 2010Inventor: Göran Lindgren
-
Patent number: 7666845Abstract: The invention is directed to compounds of the formula (I) described herein, a pharmaceutically acceptable salt thereof, or a prodrug thereof, and pharmaceutical compositions and methods of treatment.Type: GrantFiled: December 3, 2007Date of Patent: February 23, 2010Assignee: Janssen Pharmaceutica N.V.Inventors: Kevin L. Cook, Heng-Keang Lim, Frank J. Villani, Lorraine Scott, Christian Andrew Baumann
-
Publication number: 20100029930Abstract: The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-?-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.Type: ApplicationFiled: November 18, 2005Publication date: February 4, 2010Inventors: Lill Torild Wickstrom, Dirk-Jan in't Veld, Nigel John Osborn, Julian Grigg, Anthony Wilson
-
Publication number: 20100008856Abstract: Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C1 preferred conformation, radio-labeled with 18F, 123I, or 124I, or free hexoses radiolabeled with 18F, 123I, or 124I. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.Type: ApplicationFiled: May 23, 2006Publication date: January 14, 2010Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ernest M. Wright, Jorge R. Barrio, Bruce A. Hirayama, Vladimir Kepe
-
Publication number: 20090318678Abstract: The invention concerns a C-glycoside compound of formula (I); wherein: n is equal to 1 or 2; Y represents H or halogen; X is an alkyl chain bearing at least one amino, amide, acid, ester, carbonyl, alcohol, aryl function or a carbonyl, ester amide, amino, alcohol group; the R's, identical or different, represent a OH or OR? group where R? is an alkyl, benzyl, benzoyl, acetyl, pivaloyl, trialkylsilyl, tertiobutyldiphenylsilyl group or one or more sugars; R1 represents OR?, NR?R??, N3, or a phthalamide with R? and R??, identical or different, represent H or an alkyl, aryl, benzyl, benzoyl, acetyl, alkoxycarbonyl, allyloxycarbonyl, benzyloxycarbonyl group; R2 represents H or halogen or a OH, OR, NR?R?? or N3 group, as well as derivatives thereof in physiologically or pharmaceutically acceptable base, mineral or organic acid-addition salt, hydrate or solvate form.Type: ApplicationFiled: April 23, 2007Publication date: December 24, 2009Applicant: TFCHEMInventors: Géraldine Castelot-Deliencourt-Godefroy, Jean-Charles Quirion, Philippe Jubault, Ludivine Zoute
-
Patent number: 7626016Abstract: This invention relates to a method for preparing a sucrose-6-ester.Type: GrantFiled: August 20, 2007Date of Patent: December 1, 2009Assignee: Hebei Sukerui Science and Technology Co., Ltd.Inventors: Jun Jing Wu, Guang Li Wu, Qing Hai Cai, Shou Xinyu, Zi Wen Li, Shang Liu, Man Tang Wang
-
Publication number: 20090286757Abstract: Chemical compounds, being the alkyl sulfate of sulfated saccharides, particularly, dextrin, dextran, and cyclodextrin, and pharmaceutical compositions containing these compounds. The compounds of the invention provide antiviral activity, particularly in the treatment and prevention of sexually-transmitted diseases. Methods of treating viral infection and preventing viral transmission include administration include administration of the compounds of the invention orally, topically, subcutaneously, by muscular injection, by intraperitoneal injection and by intravenous injection.Type: ApplicationFiled: February 6, 2009Publication date: November 19, 2009Inventor: Roger Hershline
-
Publication number: 20090233874Abstract: The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.Type: ApplicationFiled: September 9, 2008Publication date: September 17, 2009Inventors: Ahmed F. Abdel-Magid, Maureen Chisholm, Steven Mehrman, Lorraine Scott, Kenneth M. Wells, Fan Zhang-Plasket, Sumihiro Nomura, Mitsuya Hongu, Yuichi Koga
-
Patent number: 7589193Abstract: A compound of the formula I A method is also provided for treating diabetes and related diseases employing the above compound alone or in combination with another therapeutic agent.Type: GrantFiled: September 23, 2005Date of Patent: September 15, 2009Assignee: Bristol-Myers Squibb CompanyInventors: William Washburn, Wei Meng
-
Publication number: 20090215148Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and the 3-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivate compounds having one or more benzo nitrogens.Type: ApplicationFiled: October 6, 2008Publication date: August 27, 2009Inventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing
-
Patent number: 7572929Abstract: Dithiocarbonate-containing macromer that contain biodegradable or water-soluble segments, and polymers derived from the reaction of these dithiocarbonate-containing macromers, are disclosed. The polymers derived from these dithiocarbonate-containing macromers with biodegradable or water-soluble segments are useful in medical and pharmaceutical applications.Type: GrantFiled: March 27, 2006Date of Patent: August 11, 2009Assignee: Ethicon, Inc. - USAInventors: Ankur S. Kulshrestha, Kevin Cooper, Walter R. Laredo
-
Publication number: 20090156516Abstract: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.Type: ApplicationFiled: December 11, 2008Publication date: June 18, 2009Inventors: Yuanwei Chen, Kun Peng, Lili Zhang, Binhua Lv, Baihua Xu, Jiajia Dong, Jiyan Du, Yan Feng, Ge Xu, Vasanthakumar Rajappan, Brian Seed
-
Publication number: 20090118201Abstract: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.Type: ApplicationFiled: August 22, 2008Publication date: May 7, 2009Inventors: Yuanwei Chen, Huawei Cheng, Shengbin Li, Yuelin Wu, Yan Feng, Binhua Lv, Baihua Xu, Brian Seed, Michael J. Hadd, Yanli Song, Jiyan Du, Congna Wang, Jacques Y. Roberge
-
Publication number: 20090118493Abstract: A process of azeotropic removal of dimethylformamide, abbreviated as DMF, from a process stream containing DMF requiring its removal, is described wherein the said Process Stream being obtained in a process for preparation of 4,1?,6? trichlorogalactosucrose, abbreviated as TGS, or TGS-6-ester including TGS-6-acetate or TGS-6-benzoate, comprising steps of (a) evaporation of the said process stream under reduced pressure to a concentrate to effect removal of a part of DMF azeotropically, (b) diluting the concentrate obtained at the end of step (a.) of this claim with water, preferably to about 5 to 10 times the volume of the said concentrate, and (c) repeating the cycles of evaporation under reduced pressure and dilution with water for more number of times until content of DMF in the concentrated mass is reduced to 0.5% or less of the concentrate.Type: ApplicationFiled: August 29, 2006Publication date: May 7, 2009Applicant: PHARMED MEDICARE PVT. LTD.Inventors: Rakesh Ratnam, Sundeep Aurora, Batchu Chandrasekhar
-
Publication number: 20090069252Abstract: The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via —X— and A ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes related diseases such as an insulin-resistant diseases and obesity.Type: ApplicationFiled: July 15, 2008Publication date: March 12, 2009Applicants: Astellas Pharma Inc., Kotobuki Pharmaceutical Co., Ltd.Inventors: Masakazu Imamura, Takeshi Murakami, Ryota Shiraki, Kazuhiro Ikegai, Takashi Sugane, Fumiyoshi Iwasaki, Eiji Kurosaki, Hiroshi Tomiyama, Atsushi Noda, Kayoko Kitta, Yoshinori Kobayashi
-
Publication number: 20090036668Abstract: Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.Type: ApplicationFiled: April 14, 2008Publication date: February 5, 2009Inventors: Arkadij M. Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth Kolb, R. Michael van Dam, Lawrence Talcott Diener, Sean Ford, Reza Miraghaie
-
Publication number: 20090035787Abstract: Iduronic acid (IdoUA)-free heparan sulfate (HS)-like compounds are provided. Also provided are methods of synthesizing IdoUA-free HS-like compounds. The methods can include providing at least one O-sulfotransferase (OST) enzyme and a reaction mixture comprising 3?-phosphoadenosine 5?-phosphosulfate (PAPS); and incubating a polysaccharide substrate with the at least one OST and the reaction mixture, whereby the HS-like compounds are synthesized. Also disclosed are methods of synthesizing a library of HS-like compounds and methods of determining the mechanism of activity of HS-like compounds.Type: ApplicationFiled: July 23, 2008Publication date: February 5, 2009Inventors: Jian Liu, Courtney Jones, Jinghua Chen, Yongmei Xu
-
Publication number: 20090030191Abstract: The present invention provides a process capable of industrially producing 5-deoxy-L-arabinose, important as a raw material for the production of sapropterin useful as a therapeutic agent for atypical hyperphenylalaninemia, satisfactorily efficiently even with a simple production apparatus. Provided is the process for producing 5-deoxy-L-arabinose characterized by including: reacting L-rhamnose with a C11-16 straight chain alkyl mercaptan compound in the presence of an acid catalyst to prepare L-rhamnose dialkylmercaptal; subjecting then the obtained compound to an oxidation reaction to prepare a sulfonyl derivative; and subjecting then the sulfonyl derivative to a carbon-reduction reaction to prepare 5-deoxy-L-arabinose.Type: ApplicationFiled: December 28, 2005Publication date: January 29, 2009Inventors: Mitsuhito Okitsa, Katsuhide Kamei
-
Publication number: 20090030192Abstract: A process for the production of [18F]fluoro-2-deoxyglucose can produce [18F]fluoro-2-deoxyglucose in a high and stable yield of synthesis. A process for the production of a compound labeled with radioactive fluorine includes the preparing a reaction solution by adding, under a hermetic condition, TATM and an inert organic solvent to a mixture containing [18F]fluoride ions, a phase transfer catalyst and potassium ions, giving a reaction condition to the reaction solution under a hermetic condition to obtain [18F]-TAFDG, and subjecting the obtained [18F]fluoro-2-deoxyglucose to a deprotection process and, optionally, to a purification process to obtain [18F]fluoro-2-deoxyglucose.Type: ApplicationFiled: November 30, 2006Publication date: January 29, 2009Applicant: Nihon Medi-Physics Co., Ltd.Inventors: Keiichi Hirano, Daisaku Nakamura
-
Publication number: 20090029927Abstract: The invention is directed to compounds of the formula (I) described herein, a pharmaceutically acceptable salt thereof, or a prodrug thereof, and pharmaceutical compositions and methods of treatment.Type: ApplicationFiled: December 3, 2007Publication date: January 29, 2009Inventors: Kevin L. Cook, Heng-Keang Lim, Frank J. Villani, Lorraine Scott, Christian Andrew Baumann
-
Publication number: 20080281090Abstract: New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.Type: ApplicationFiled: December 5, 2005Publication date: November 13, 2008Applicants: CALIFORNIA INSTITUTE OF TECHNOLOGY, FLUIDIGM CORPORATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SIEMENS CORPORATIONInventors: Cheng-Chung Lee, Guodong Sui, Arkadij Elizarov, Hartmuth C. Kolb, Jiang Huang, James R. Heath, Michael E. Phelps, Stephen R. Quake, Hsian-rong Tseng, Paul Wyatt, Antoine Daridon
-
Publication number: 20080242596Abstract: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.Type: ApplicationFiled: April 1, 2008Publication date: October 2, 2008Applicant: Theracos, Inc.Inventors: Yuanwei Chen, Yan Feng, Baihua Xu, Binhua Lv, Brian Seed, Michael J. Hadd, Huawei Cheng, Zelin Sheng, Min Xu, Congna Wang, Jiyan Du, Lili Zhang, Ge Xu, Yuelin Wu
-
Patent number: 7417109Abstract: Disclosed are novel polymers derivatized with at least one —NOx group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.Type: GrantFiled: August 7, 2006Date of Patent: August 26, 2008Assignee: Duke UniversityInventors: Jonathan S. Stamler, Eric J. Toone, Richard S. Stack
-
Publication number: 20080146515Abstract: A novel crystal form of 1-(?-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene hemihydrate, and having favorable characteristics, is characterized by its x-ray powder diffraction pattern and/or by its infra-red spectrum.Type: ApplicationFiled: December 3, 2007Publication date: June 19, 2008Applicant: Mitsubishi Tanabe Pharma CorporationInventors: Sumihiro Nomura, Eiji Kawanishi
-
Publication number: 20080124294Abstract: The invention relates to novel amphoteric polysaccharide compounds containing sulfonate function(s) corresponding to the formula (I) in which P represents a polysaccharide chain; X, Y and Z each represent a linear or branched, saturated or unsaturated, optionally hydroxylated C1-C12 divalent hydrocarbon-based group optionally comprising at least one ether and/or amine function in the hydrocarbon-based chain, or a group —Si(R)2—[O—Si(R)2]q-A-; r is 0 or 1; An represents an anionic group chosen from formula (II) CAT represents a quaternary ammonium group or a cationic polymer chain obtained by grafting and polymerization of ethylenic monomers bearing a quaternary ammonium function, Sulfo represents a sulfonic or sulfonate group; and n, m and p are such that the total degree of substitution of the polysaccharide does not exceed 2. The invention also relates to compositions comprising them and to their use in cosmetics.Type: ApplicationFiled: August 19, 2005Publication date: May 29, 2008Inventor: Michel Philippe
-
Patent number: 7378519Abstract: Processes for isolation and purification of enantiomerically enriched compositions comprising tramadol and topiramate, and also for the subsequent isolation of 1S,2S-tramadol hydrochloride, are disclosed herein.Type: GrantFiled: May 16, 2003Date of Patent: May 27, 2008Assignee: Cilag GmbH InternationalInventors: Rainer Naeff, Sonja Spycher-Huber, Thomas Hunziker, Guenter Laufer
-
Publication number: 20080103298Abstract: In one embodiment of the invention a method to prepare sucralose-6-acylate through chlorinating sucrose-6-acylater by BTC in the process of sucralose preparation is disclosed. In this embodiment a Vilsmeier reagent is firstly prepared below 0° C. by dissolving BTC in DMF or in component solvent, containing DMF, toluene, dichloroethane, chloroform and carbon tetrachloride. Consequently, sucrose-6-ester was chlorinated by Vilsmeier reagent. BTC can also be dissolved in one or several organic solvent such as toluene, dichloroethane, chloroform and carbon tetrachloride, and added to a DMF solution of sucrose-6-acylate for chlorination. Sucralose was prepared through de-esterifying the obtained sucralosed 6-ester using sodium methoxide/methanol or sodium ethoxide/ethanol.Type: ApplicationFiled: October 25, 2006Publication date: May 1, 2008Inventors: David Losan Ho, Wan Zhenghao
-
Patent number: 7345166Abstract: Novel antenna polymers characterized by a polymeric background of a biodegradable water soluble polymer and chromophores chemically bonded to the polymeric background have been found to be useful as photocatalysts in aqueous media. On completion of the desired photochemical reaction, the residual medium can safely be discharged to the natural environment as the catalyst residues undergo biodegradation to form environmentally harmless products.Type: GrantFiled: October 23, 2003Date of Patent: March 18, 2008Inventors: James E. Guillet, Maria Nowakowska
-
Patent number: 7345117Abstract: The present invention relates to the synthesis of a haemocompatible polymer, consisting of a polyurethane bound covalently to sulphated hyaluronic acid. These sulfated derivatives have anticoagulative, non-thrombogenic, antiviral and anti-inflammatory properties. They also have the ability to inhibit platelet adhesion, aggregation and activation. The invention is particularly advantageous in resisting the enzyme hyaluronidase, therefore ensuring anti-coagulant activities for longer periods of time when compared to similar compounds. This biocompatible polymer material is well suited for surgical or other medicinal uses.Type: GrantFiled: February 24, 1999Date of Patent: March 18, 2008Inventors: Rolando Barbucci, Marco Consumi, Agnese Magnani, Lanfranco Callegaro
-
Publication number: 20080038191Abstract: Positron emitting compounds and methods of their production are provided. The compounds have the formula: (F)m G (R)n wherein each R is a group comprising at least one carbon, nitrogen, phosphorus or sulfur atom and G is joined to R through said carbon, nitrogen, phosphorus or sulfur atom; G is silicon or boron; m is 2 to 5 and n is 1 to 3 with m+n=3 to 6 when G is silicon; m is 1 to 3 and n is 1 to 3 with m+n=3 to 4 when G is boron; and wherein the compound further comprises one or more counterions when the above formula is charged; and wherein at least one F is 18 F.Type: ApplicationFiled: February 14, 2005Publication date: February 14, 2008Inventors: David M. Perrin, Richard Ting
-
Patent number: 7244830Abstract: A glycopolymer composition is provided comprising glycopolymer molecules having a polymer backbone; a first pendent unit comprising a linking group connected to said polymer backbone and a saccharide moiety connected to said linking group, optionally a second pendent unit; a phenyl ring at a first end of the polymer backbone; and a cyanoxyl group at the second end of the polymer backbone, useful as intermediates for making bioactive glycopolymers which bind to bioactive molecules, viruses, cells and substrates for protein separation, cell culture, ad drug delivery systems, as well as in targeting for treatment of wound healing and other pathological conditions.Type: GrantFiled: January 14, 2002Date of Patent: July 17, 2007Assignee: Emory UniversityInventors: Elliot L. Chaikof, Daniel Grande, Subramanian Baskaran
-
Patent number: 7189843Abstract: The methods of the present invention prepare carrageenan products from processed seaweed material having a solids content of less than 25% by weight solids, using shear stress treatment. The carrageenan products comprise at least about 60% by weight of carrageenan and at least about 2% by weight of acid insoluble material. The carrageenan products of the present invention are useful as components in food products, such as, dairy products, meats, and dessert gels as well as non-food products, such as, toothpaste formulations, cosmetics, paints, films and delivery capsules.Type: GrantFiled: December 10, 2001Date of Patent: March 13, 2007Assignee: FMC CorporationInventors: Albert G. Tsai, Linnea K. S. Ledwith, Robert Kopesky, Maurice Gerard Lynch, William Ross Blakemore, Peter J. Riley
-
Patent number: 7115586Abstract: The invention provides a number of methods for enhancing the aqueous solubility of an active ingredient which is insoluble or sparingly soluble in water. In one preferred embodiment, solubilization of the active ingredient is enhanced by combining it with ?-cyclodextrin in an aqueous complexation medium comprising ?-cyclodextrin and a negatively- or positively-charged compound which forms an inclusion or non-inclusion complex with ?-cyclodextrin and its inclusion complexes.Type: GrantFiled: October 18, 2002Date of Patent: October 3, 2006Assignee: Decode Genetics EHF.Inventor: Thorsteinn Loftsson
-
Patent number: 7087571Abstract: The invention relates to a series of polyglycoside derivatives that contain water-soluble sulfosuccinate groups introduced into the molecule by reaction with the hydroxyl groups present in the starting polyglycoside molecule, with the chloro material. The preferred products have more than one water-soluble group per molecule and are made with mild reagents to avoid discoloration and mal odor. The most preferred products have between 2 and 3 functional groups per molecule.Type: GrantFiled: January 25, 2005Date of Patent: August 8, 2006Assignee: Colonial ChemicalInventors: Anthony J. O'Lenick, Jr., Dean Smith
-
Patent number: 7087709Abstract: Disclosed are novel polymers derivatized with at least one —NOx group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.Type: GrantFiled: February 8, 2005Date of Patent: August 8, 2006Assignee: Duke UniversityInventors: Jonathan S. Stamler, Eric J. Toone, Richard S. Stack
-
Patent number: 7084132Abstract: A stable form of artemisinin wherein an artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably, ?-cyclodextrin. The complexed cyclodextrin artemisinin formulation shields the peroxide portion of the artemisinin backbone from hydrolytic decomposition rendering it stable in solution. Artelinic acid and cyclodextrin are placed into contact with one another to yield a 2:1 molecular species. Artesunic acid and cyclodextrin yield a 1:1 molecular species. The complexed cyclodextrin artemisinin formulation is effective for the treatment of malaria and is stable in solution for long periods of time.Type: GrantFiled: April 25, 2005Date of Patent: August 1, 2006Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Mark G. Hartell, Apurba K. Bhattacharjee, Rickey P. Hicks, John E. VanHamont, Wilbur K. Milhous
-
Patent number: 7074919Abstract: The invention concerns the use, in a composition for treating textile fiber articles in aqueous or moist medium, of an amphoteric polysaccharide, whereof the native skeleton is a polysaccharide consisting of a main chain comprising anhydrohexose units and branches comprising at least a neutral or anionic anhydropentose and/or anhydrohexose unit, the anhydrohexose and/or anhydropentose units being substituted of modified by groups bearing at least a (potentially) anionic load and/or at least a (potentially) cationic load, the degree of substitution or modification by the set of said groups bearing (potentially) anionic loads ranging between 0.01 and less than 3, with a ratio of the number of (potentially) anionic charges over the number of (potentially) cationic loads ranging between 99.5/0.Type: GrantFiled: December 20, 2001Date of Patent: July 11, 2006Inventors: Eric Aubay, Etienne Fleury, Ian Harrison
-
Patent number: 7060685Abstract: Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids, which include a portion or analogue thereof) linked to a carbohydrate or glycomimetic.Type: GrantFiled: May 16, 2003Date of Patent: June 13, 2006Assignee: GlycoMimetics, Inc.Inventors: John L Magnani, John T Patton, Jr., Leonard M Williams
-
Patent number: 7030237Abstract: In a reaction system having at least two liquid-liquid interfaces between an organic phase of raw material containing a compound(s) to be separated and an aqueous phase of an aqueous solution of inclusion-complexing agent and between that aqueous phase and an organic phase(s) of extraction solvent(s), the compound(s) to be separated is entrapped into the aqueous phase through formation of an inclusion complex(es) of the inclusion-complexing agent with the compound(s), while the compound(s) is entrapped into the organic phase(s) of extraction solvent(s) through dissociation of said inclusion complex(es). The foregoing operation is performed using, for example, a squarish U-shaped tube or an H-shaped tube with bottom plates. Preferred examples of inclusion-complexing agent include highly water-soluble branched cyclodextrins.Type: GrantFiled: December 21, 2000Date of Patent: April 18, 2006Assignees: National Institute of Advanced Industrial Science and Technology, Ensuiko Sugar Refining Co. Ltd., Bio Research Corporation of YokohamaInventors: Isamu Uemasu, Kozo Hara, Hideki Takahashi
-
Patent number: 7022682Abstract: The present invention provides for a method for treatment and prevention of Type II Diabetes Mellitus and its complications comprising the step of administering to a patient a therapeutically-effective amount of Rhamnan Sulphate, its functional analogs, or its physiologically acceptable salts, in therapeutic proportions. Anticoagulation activity in the blood plasma of a patient is not appreciably increased.Type: GrantFiled: May 14, 2003Date of Patent: April 4, 2006Assignee: Endomatrix, Inc.Inventor: Bruce Alan Daniels
-
Patent number: 7001893Abstract: The present invention relates to an inclusion complex of Rifampicin and cyclodextrin (CD) that can be used as an anti-tubercular drug. The present invention also relates to a process for synthesizing inclusion complexes of the anti-tubercular drug, Rifampicin, with ?-CD (?-cyclodextrin) and HP-?-CD (2-hydroxy propyl cyclodextrin) and characterization of these inclusion complexes.Type: GrantFiled: October 28, 2002Date of Patent: February 21, 2006Assignee: Council of Scientific and Industrial ResearchInventors: Kakulapati Rama Rao, Nanduri Bhanumathi, Jhillu Singh Yadav, Neelam Srilakshmi Krishnaveni
-
Patent number: 6984732Abstract: A composition for sweetening ingestable solids or liquids. The composition is compressed and comprises less than about 7.5 weight-% sucralose and one or more diluents. The composition is compressed at a pressure of greater than 2 pounds per square inch. A method of forming the composition and a system for delivering the composition are also provided.Type: GrantFiled: March 31, 2003Date of Patent: January 10, 2006Assignee: McNeil-PPC, Inc.Inventors: Steven Catani, Anne-Lise Lucas
-
Patent number: 6951846Abstract: A stable form of artemisinin wherein an artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably, ?-cyclodextrin. The complexed cyclodextrin artemisinin formulation shields the peroxide portion of the artemisinin backbone from hydrolytic decomposition rendering it stable in solution. Artelinic acid and cyclodextrin are placed into contact with one another to yield a 2:1 molecular species. Artesunic acid and cyclodextrin yield a 1:1 molecular species. The complexed cyclodextrin artemisinin formulation is effective for the treatment of malaria and is stable in solution for long periods of time.Type: GrantFiled: February 27, 2003Date of Patent: October 4, 2005Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Mark G. Hartell, Apurba K. Bhattacharjee, Rickey P. Hicks, John E. VanHamont, Wilbur K. Milhous
-
Patent number: 6951934Abstract: The present invention relates to a novel method of chemically preparing functionalized derivatives of ?-(1,3)-glucans, enabling obtaining oligosaccharides which are free or which comprise specific groups such as, for example, sulphate, phosphate, methyl, in pre-defined positions. This method includes a reaction between a glycosyl donor of formula (Ia) or (Ib) and a glycosyl acceptor of formula (II), defined in the claims. Application: Preparation of biologically active compounds which can be used in the agricultural, cosmetic or pharmaceutical fields.Type: GrantFiled: February 2, 2001Date of Patent: October 4, 2005Assignee: Laboratories GoemarInventors: Jean-Claude Yvin, Frank Jamois, Vincent Ferrieres, Daniel Plusquellec