Disaccharides (e.g., Maltose, Sucrose, Lactose, Formaldehyde Lactose, Etc.) Patents (Class 536/123.13)
  • Patent number: 9795561
    Abstract: The present invention is directed to pharmaceutical combination products comprising a muscarinic acetylcholine receptor antagonist, fluticasone propionate and salmeterol xinafoate, and to their use in the treatment of inflammatory or respiratory tract diseases.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: October 24, 2017
    Assignee: Glaxo Group Limited
    Inventor: Christine Elaine Jones
  • Patent number: 9376506
    Abstract: [Problem to be Solved] The importance of sugar chains having ?2,3- or ?2,6-linked sialic acid at their non-reducing ends is known. Industrial production has been demanded for these sugar chain compounds. Particularly, the production of glycoprotein drugs or the like inevitably requires producing in quantity sugar chains having homogeneous structures by controlling the linking pattern (?2,6-linkage or ?2,3-linkage) of sialic acid. Particularly, a triantennary or tetraantennary N-type complex sugar chain having sialic acid at each of all non-reducing ends is generally considered difficult to chemically synthesize. There has been no report disclosing that such a sugar chain was chemically synthesized. Furthermore, these sugar chains are also difficult to efficiently prepare enzymatically.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: June 28, 2016
    Assignee: GLYTECH, INC.
    Inventors: Yasunori Chiba, Yoshie Takahashi, Hisashi Narimatsu, Kazuhiro Fukae
  • Patent number: 9309276
    Abstract: The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: April 12, 2016
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Geert-Jan Boons
  • Publication number: 20150140090
    Abstract: A composition for treating inflammation and pain, including a hydrogen-generating compound in an amount that increases the amount of hydrogen in an individual and has an anti-inflammatory effect. A composition for treating inflammation and pain, including synergistically effective amounts of pregabalin and lactulose. A method of treating inflammation and pain, by administering a composition comprising a hydrogen-generating compound to an individual in an amount that increases the amount of hydrogen in the individual and has an anti-inflammatory effect.
    Type: Application
    Filed: January 4, 2013
    Publication date: May 21, 2015
    Inventors: Toshihisa Kawai, Kenneth I. Kohn
  • Publication number: 20150141524
    Abstract: The invention relates to a method for the production of a solid bio-product wherein at least 80% of the original indigestible oligosaccharide (raffmose, stachyose and verbascose) content has been degraded into digestible mono- and disaccharides, comprising the following steps: 1) providing a mixture of milled or flaked or otherwise disintegrated biomass, comprising oligosaccharides and optionally polysaccharides and further comprising proteinaceous plant parts, water and one or more enzyme preparations containing ?-galactosidase(s); 2) reacting the mixture resulting from step (1) under continuous mixing and under conditions where the water content in the initial mixture does not exceed 65% by weight, for 0.15-36 hours at a temperature of about 20-65° C.; 3) incubating the reacted mixture from step (2) at a temperature and in a time period which inactivate said ?-galactosidase(s), as well as solid bio-products obtainable by such method.
    Type: Application
    Filed: May 5, 2013
    Publication date: May 21, 2015
    Applicant: Hamlet Protein A/S
    Inventors: Katrine Hvid Ellegard, Karl Kristian Thomsen, Ole Kaae Hansen
  • Publication number: 20150105546
    Abstract: Process for recovery and separation of sugars and oil from plants where the stems and leaves of such plants have substantial levels of both sugars and oils.
    Type: Application
    Filed: October 14, 2014
    Publication date: April 16, 2015
    Inventors: Stephen P. Long, Vijay Singh, Haibo Huang
  • Publication number: 20150098987
    Abstract: An object of the present invention is to provide a trans-resveratrol derivative that resists isomerization to the cis-form. This object can be achieved by a method for producing a trans-resveratrol polysaccharide, the method comprising the step of bringing a trans-resveratrol glucoside into contact with sugar in the presence of ?-cyclodextrin glucanotransferase.
    Type: Application
    Filed: July 11, 2014
    Publication date: April 9, 2015
    Inventors: Hiroki HAMADA, Shinichi KOJIMA, Shoji TAKAHASHI, Chiemi MOMOTA
  • Patent number: 8986667
    Abstract: The present invention relates to a mixture, having a skin-tightening effect, which is made up of: 10 to 80% by weight of a polysaccharide, preferably of an alginate, having a molecular weight of less than 600,000 Daltons, preferably less than 400,000 Daltons and more preferably less than 200,000 Daltons, 15 to 75% by weight of a polyhydroxylated agent selected from sugars and their derivatives, particularly sugar esters and sugar, ethers, preferably sorbitol, 3 to 15% by weight of poly(vinyl alcohol) or polyvinylpyrrolidone, and 0 to 25% by weight of cellulose or of a derivative of cellulose, such as carboxymethylcellulose or hydroxymethylcellulose. The present invention also relates to cosmetic compositions which contain this mixture. These cosmetic compositions enable a mechanical smoothing of the surface of the skin to be obtained progressively with great comfort of use and enables a good fixing of make-up products.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: March 24, 2015
    Assignee: LVMH Recherche
    Inventors: Hervé Delage-Grouiller, Brigitte Noe, Christian Mahe
  • Publication number: 20150072952
    Abstract: The present invention relates to novel glycomimetic compounds that are rationally designed to inhibit the binding of various pathogens to cell surface sialylated galactose and methods of use thereof. Specifically sialic acid glycosides and C-glycosides are disclosed that form a lactam ring structure or a cyclic ether/amine ring structure with the adjacent monosaccharide residue.
    Type: Application
    Filed: March 14, 2013
    Publication date: March 12, 2015
    Inventors: Robert J. Woods, Paul V. Murphy, Loretta Yang, Hannah M.K. Smith, Jenifer Hendel
  • Publication number: 20150065450
    Abstract: The present invention is related to a compound conjugating a drug with a glycosaminoglycan, such as hyaluronic acid (HA), where the drug is useful for the treatment of diseases such as inflammation, auto-immune disease, allergy, infection and preferably cancer. The conjugated compound of the present invention can increase the concentration of drug at the specific site of disease by an interaction of the glycosaminoglycan used as target drug delivery carrier and the CD44 cell surface receptor, then enhancing the therapeutic efficacy and reducing the systemic side effect of the site-delivered drug.
    Type: Application
    Filed: August 26, 2014
    Publication date: March 5, 2015
    Inventor: Hua-Yang Lin
  • Publication number: 20150050282
    Abstract: The present invention relates to compounds derived from sugars which reproduce the epitopes of Shigella flexneri serotypes 3a and X and to the use thereof for the preparation of vaccine compositions. More specifically, the subject matter of the present invention relates to novel glycoconjugated compounds comprising oligosaccharides or polysaccharides described hereinafter, to the method for synthesizing these oligosaccharides or polysaccharides and glycoconjugates, to derivatives of these oligosaccharides or polysaccharides, to compositions containing same, and also to the use of the glycoconjugates for vaccination purposes. Finally, the present invention relates to methods for diagnosing a Shigella flexneri infection using one or more oligosaccharides or polysaccharides or conjugates thereof.
    Type: Application
    Filed: June 20, 2014
    Publication date: February 19, 2015
    Applicants: INSTITUT PASTEUR, Centre National De La Recherche Scientifique, Universite Paris Descartes
    Inventors: Laurence MULARD, Julien BOUTET, Catherine GUERREIRO, Farida NATO, Philippe SANSONETTI, Armelle PHALIPON
  • Publication number: 20150038455
    Abstract: The present disclosure provides for methods and compositions comprising a series of synthetic glycopolymers. The disclosure also relates to a kit which is suitable for carrying out the inventive methods.
    Type: Application
    Filed: August 1, 2014
    Publication date: February 5, 2015
    Inventors: Gloria J. Sheng, Linda C. Hsieh-Wilson
  • Publication number: 20150031874
    Abstract: The present invention relates to a process for producing a syrup which is rich in maltose. The process is comprising the successive steps of liquefaction of a starch milk and saccharification of the liquefied starch milk in the presence of alpha-amylase, beta-amylase and a debranching enzyme selected from the group of pullulanase, iso-amylase and mixtures thereof, preferably pullulanase and further adding maltogenic alpha-amylase and/or iso-amylase, for obtaining a maltose containing syrup comprising at least 85% maltose based on dry matter and less than 1.5% glucose based on dry matter, preferably less than 1% glucose based on dry matter.
    Type: Application
    Filed: January 24, 2013
    Publication date: January 29, 2015
    Applicant: Cargill, Incorporated
    Inventors: Tiziano Furlan, Luigi Nataloni, Patrizia Tolomelli
  • Publication number: 20150025035
    Abstract: The invented inositol and trehalose derivatives, prepared by introducing multiple units of the guanidine group to the backbone molecules, show excellent blood-brain barrier permeability, and accordingly, it can be easily transported to the brain tissues and utilized for the treatment of neurodegenerative diseases such as Alzheimer's disease and Huntington's disease.
    Type: Application
    Filed: October 8, 2014
    Publication date: January 22, 2015
    Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Sung-Kee CHUNG, Woo Sirl LEE, Boram KIM, Jungkyun IM, Subhash C. GHOSH
  • Publication number: 20150017699
    Abstract: The present invention is generally directed to internally functionalized graphene substrates, methods of making such substrates and methods of using such substrates. In one aspect, the present invention is a graphene substrate. The substrate comprises edge and non-edge regions. Organic or inorganic molecules are bound to the non-edge regions of the substrate, and the organic or inorganic molecules are present on the substrate edges at a population greater than about one molecule per 10,000 nm2.
    Type: Application
    Filed: July 9, 2014
    Publication date: January 15, 2015
    Applicant: NANOTECH BIOMACHINES, INC.
    Inventors: Jeffrey Alan McKinney, William Emerson Martinez
  • Patent number: 8912320
    Abstract: A process for removing dimethylamine (DMA) before and/or during and/or after deacylation in a reaction vessel of a feed stream comprising a sucralose-6-acylate resulting from the chlorination of a sucrose-6-acylate in the presence of dimethyl formamide (DMF), wherein the deacylation is conducted at a first set of conditions of temperature, pH and pressure, the process comprising: (a) providing a side stream loop from and to the reaction vessel; (b) adjusting the conditions of one or more of temperature, pH, and pressure in the loop, and setting the flow rate through the loop, to remove DMA while minimising carbohydrate degradation.
    Type: Grant
    Filed: March 24, 2010
    Date of Patent: December 16, 2014
    Assignee: Tate & Lyle Technology Limited
    Inventors: John Kerr, Robert Jansen, Anthony Baiada, Duane Leinhos, James Edwin Wiley
  • Patent number: 8877735
    Abstract: Purified alkoxylated sucrose esters of the formula: wherein R is independently selected from: COR?; (CH2CH2O)xH; and (CH2CH2O)x COR?; wherein R? is a fatty acid compound having from about 2 to about 28 carbon atoms; and wherein x is a number selected from about 1 to about 50; wherein at least one of the R groups is an ester group that is directly esterified to the sucrose backbone; and wherein the alkoxylated sucrose ester composition further comprises: less than 1% aldehydes; less than 1% ketones; less than 1% benzyl halide; less that 1% mono-benzyl ether; less than 1% acetals; and less than 1% ketals.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: November 4, 2014
    Assignee: The Procter & Gamble Company
    Inventor: Jared John Schaefer
  • Publication number: 20140303359
    Abstract: Disclosed is a method for selective synthesis of 1,2-cis-?-linked glycosides which does not require the use of the specialized protecting group patterns normally employed to control diastereoselectivity. Thioglycoside acceptors can be used, permitting iterative oligosaccharide synthesis. The approach eliminates the need for lengthy syntheses of monosaccharides possessing highly specialized and unconventional protecting group patterns.
    Type: Application
    Filed: April 8, 2014
    Publication date: October 9, 2014
    Applicant: Trustees of Tufts College
    Inventors: Clay S. Bennett, An-Hsiang Adam Chu
  • Publication number: 20140275517
    Abstract: Methods and systems for the preparation of conditioned micronized active agents. Additionally, methods and systems for in-process conditioning of micronized active agent particles and compositions comprising conditioned micronized materials.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Pearl Therapeutics, Inc.
    Inventors: Ali Kazmi, David Lechuga, Herm Snyder, James Ivey, Reinhard Vehring, Jason H. Speck, Sarvajna Dwivedi
  • Publication number: 20140271632
    Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: AbbVie, Inc.
    Inventors: Patrick Hossler, Sean McDermott, Christopher Racicot, Ivan Correia
  • Publication number: 20140256931
    Abstract: The present disclosure relates carbonaceous materials and to methods of using such carbonaceous materials for purifying oligomers produced from depolymerized biomass, such as lignocellulosic biomass.
    Type: Application
    Filed: October 18, 2012
    Publication date: September 11, 2014
    Applicants: BP CORPORATION NORTH AMERICA INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Po-Wen Chung, Alexandre Charmot, Alexander Katz, Amit A. Gokhal
  • Patent number: 8828967
    Abstract: New low molecular weight complexes between iron and maltobionic acid that can be administered parenterally, preferably intramuscularly or subcutaneously, in the treatment of anemic states, caused by iron deficiencies, and new pharmaceutical compositions adapted for this use. In particular, the invention provides a new complex between preferably trivalent iron and maltobionic acid that is characterized by a molecular weight Mw between 10,000 and 30,000 Da, by a polydispersity of 1.0-1.8 and by an iron content between 25% and 40% by weight.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: September 9, 2014
    Assignee: Biofer S.p.A.
    Inventors: Michele Autuori, Dario Bosi, Alessandro Lapini Sacchetti, Egidio Marchi
  • Patent number: 8815239
    Abstract: The present invention relates to compounds derived from sugars which reproduce the epitopes of Shigella flexneri serotypes 3a and X and to the use thereof for the preparation of vaccine compositions. More specifically, the subject matter of the present invention relates to novel glycoconjugated compounds comprising oligosaccharides or polysaccharides described hereinafter, to the method for synthesizing these oligosaccharides or polysaccharides and glycoconjugates, to derivatives of these oligosaccharides or polysaccharides, to compositions containing same, and also to the use of the glycoconjugates for vaccination purposes. Finally, the present invention relates to methods for diagnosing a Shigella flexneri infection using one or more oligosaccharides or polysaccharides or conjugates thereof.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: August 26, 2014
    Assignees: Institut Pasteur, Centre National de la Recherche Scientifique, Universite Paris Descartes
    Inventors: Laurence Mulard, Julien Boutet, Catherine Guerreiro, Farida Nato, Philippe Sansonetti, Armelle Phalipon
  • Publication number: 20140235850
    Abstract: The invention relates to a method for making precursors of HMO core structures comprising a step of reacting an N-acetyllactosamine or lacto-N-biose derivative donor with a lactose or N-acetyllactosamine derivative acceptor, wherein the donor is an oxazoline donor.
    Type: Application
    Filed: October 1, 2012
    Publication date: August 21, 2014
    Inventors: Imre Kovács, István Bajza, Markus Hederos, Gyula Dekany, Sándor Demkó, Nikolay Khanzhin
  • Publication number: 20140235849
    Abstract: Suggested is a method for improving the yield during the production of crystalline alpha lactose, wherein (a) an aqueous lactose solution is adjusted to a temperature of between about 62 and 67° C., (b) the solution is cooled down to between about 20 and 30° C., (c) the solution is held at this temperature for 0 to 5 h, (d) subsequently, the solution is re-heated to between about 30 and 35° C., (e) the solution is held at this temperature for 0 to 5 h, (f) then the solution is cooled down to about 10° C. and (g) subsequently, the precipitated alpha lactose crystals are separated from the second mother liquor, (h) an amount of a carbohydrate compound is added to the second mother liquor such that the solubility product of the residual amount of lactose that is still soluble is exceeded, (i) the second amount of precipitated alpha lactose crystals is separated from the mother liquor, dried, and (j) both amounts of alpha lactose crystals are combined.
    Type: Application
    Filed: February 11, 2014
    Publication date: August 21, 2014
    Applicant: DMK Deutsches Milchkontor GmbH
    Inventor: Sven-Rainer Döring
  • Publication number: 20140221643
    Abstract: Provided are a fructosylated mangiferin, a preparation method therefor and a use thereof, wherein the fructosylated mangiferin has a structural formula represented by the following formula (I), the method for preparing the fructosylated mangiferin includes adding a substance with fructosylating enzymatic activity to a transformed liquid containing mangiferin for biotransformation reaction, so as to convert the mangiferin into the fructosylated mangiferin, wherein the transformed liquid contains the mangiferin and a glycosyl donor; as well as a use of the fructosylated mangiferin in preparation of a medicament for treatment of tumor-related diseases.
    Type: Application
    Filed: March 8, 2012
    Publication date: August 7, 2014
    Applicant: NANJING UNIVERSITY OF TECHNOLOGY
    Inventors: Bingfang He, Xueming Wu, Jianlin Chu, Bin Wu, Sen Zhang, Pingkai Ouyang
  • Publication number: 20140219917
    Abstract: This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.
    Type: Application
    Filed: February 26, 2014
    Publication date: August 7, 2014
    Applicants: Emory University, Georgia State Research Foundation, Georgia Tech Research Corporation
    Inventors: Niren MURTHY, Eric Seth Gilbert, Xinghai Ning, Mark Goodman, Bryan Stubblefield
  • Patent number: 8785416
    Abstract: The present invention relates to the use of a series of sulphated disaccharides for the preparation of a medicament for the treatment or prevention of a neurodegenerative and/or neurovascular disease, of a traumatic brain injury or of a traumatic spinal cord injury. The present invention also relates to the use of said sulphated disaccharides for the preparation of a neuroprotective medicament or of an antioxidant medicament. The neurodegenerative and/or neurovascular diseases are preferably: Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: July 22, 2014
    Assignees: Bioiberica, S.A., Universidad Autonoma de Madrid
    Inventors: Josep Verges Milano, Antonio Garcia Garcia, Ramon Ruhi Roura, Eulalia Montell Bonaventura, Manuela Garcia Lopez, Carlos Raul Alaez Verson, Josep Escaich Ferrer, Javier Egea Maiquez, Pilar Negredo Madrigal, Silvia Lorrio Gonzalez
  • Publication number: 20140200194
    Abstract: The invention provides a method for promoting osteogenesis, increasing bone mass or enhancing the rate of bone growth, which comprises administering to a subject an effective amount of Uraria, a part thereof or an extract thereof. Also provided are a method for treating and/or preventing osteoporosis and a method for providing neuroprotection, comprising administering to a subject an effective amount of Uraria, a part thereof or an extract thereof.
    Type: Application
    Filed: January 16, 2013
    Publication date: July 17, 2014
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventor: Mei-Hsien Lee
  • Publication number: 20140187512
    Abstract: A treatment for autism in which an effective amount of lactulose is administered in order to bind excess ammonia in the gastrointestinal tract, the bloodstream, and the nervous system in order to prevent or reverse ammonia poisoning caused by the administration of certain antibiotics. Lactulose molecules in the colon are fermented by certain bacteria. The fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and reduces neurotoxicity.
    Type: Application
    Filed: November 22, 2013
    Publication date: July 3, 2014
    Applicant: Curemark LLC
    Inventors: Joan M. Fallon, Richard Feltenstein
  • Patent number: 8765416
    Abstract: The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O-?-D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O-?-D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-?-D-glucosyl-L-ascorbic acid; and by providing a process for producing the same and uses thereof.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: July 1, 2014
    Assignee: Hayashibara Co., Ltd.
    Inventors: Takashi Shibuya, Seisuke Izawa, Tomoyuki Nishimoto, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 8759320
    Abstract: Process for the preparation of trivalent iron complexes with mono-, di- and polysaccharide sugars, consisting of the activation of the sugar by oxidation with nascent bromine generated in situ by reaction between an alkaline or alkaline earth bromine and an alkaline hypochlorite, the complexation of the activated sugar in solution with a ferric salt dissolved in an aqueous solution, the purification of the resulting solution through ultrafiltration and finally the stabilization of the trivalent iron-sugar complex by heating at a temperature between 60° C. and 100° C. for a period between 1 and 4 hours at a pH between 9.0 and 11.0.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: June 24, 2014
    Assignee: Biofer S.p.A.
    Inventors: Stefania Sacchi, Mauro Montorsi, Egidio Marchi
  • Patent number: 8729008
    Abstract: The invention relates to solubilizers for metal ions and poorly soluble metal compounds, containing an oxidation product of starch hydrolysate as a solubilizing agent, to a method for solubilizing metal ions and to the use of said solubilizer.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: May 20, 2014
    Assignee: Suedzucker Aktiengesellschaft Mannheim/Ochsenfurt
    Inventors: Alireza Haji Begli, Markwart Kunz, Christine Kroener, Matthias Moser, Bart Levecke
  • Patent number: 8728504
    Abstract: A process for solubilizing hydrophobic active ingredients in aqueous medium, which comprises using, as an assistant, at least one hyperbranched polymer (A) which is obtainable by reacting at least one hyperbranched polymeric compound having at least one primary or secondary amino group per molecule (a), selected from (a1) hyperbranched polyamides and (a2) hyperbranched polyureas, with (b) at least one mono-, di- or oligosaccharide.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: May 20, 2014
    Assignee: BASF SE
    Inventors: Bernd Bruchmann, Holger Türk, Daniel Schönfelder, Monika Haberecht, Dietmar Appelhans, Victor Boyko
  • Patent number: 8722064
    Abstract: Compounds, particularly, glucopyranosyl lipid adjuvant (GLA) compounds, having the following structure (I) are provided: or a pharmaceutically acceptable salt thereof, wherein L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, Y1, Y2, Y3, Y4, R1, R2, R3, R4, R5, R6, are as defined herein. Pharmaceutical compositions, vaccine compositions, and related methods for inducing or enhancing immune responses, are also provided.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: May 13, 2014
    Assignee: Infectious Disease Research Institute
    Inventors: Steven G. Reed, Darrick Carter
  • Patent number: 8703722
    Abstract: The present invention relates to blood group A/B/H determinant on Type 1 Core glycosphingolipids chains as recognition point for the FedF protein of F18-fimbriated Enterotoxigenic and verotoxinogenic Escherichia coli and the use of compounds comprising such determinants for the treatment of F18+ E. coli infections in pigs and in screening methods.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: April 22, 2014
    Assignee: Universiteit Gent
    Inventors: Annelies Coddens, Eric Cox, Susann Eva Teneberg
  • Patent number: 8691976
    Abstract: A low-glycemic available carbohydrate composition of the invention contains the following components: (i) 5-60 wt. % of one or more monosaccharides selected from monosaccharides other than glucose and fructose, in particular galactose, ribose and mannose; (ii) 15-95 wt. % of oligosaccharides having a length of 2 to 20 anhydromonose units, at least half of which are anhydroglucose units linked by non-?-1,4 bonds; these oligosaccharides preferably comprising disaccharides such as palatinose, isomaltose and trehalose and/or non-?-1,4 linked higher glucose-containing oligosaccharides; (iii) 0-45 wt. % of other available carbohydrates, such as glucose and maltodextrins. This carbohydrate composition can be part of a food composition for the treatment of diabetes, obesitas, insulin resistance, or for postprandial glucose response.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: April 8, 2014
    Assignee: N.V. Nutricia
    Inventors: Katrien Maria Jozefa van Laere, Houkje Bouritius, Mirian Lansink
  • Patent number: 8691797
    Abstract: Disclosed is a method for chlorinating a carbohydrate or a derivative thereof to produce a polychlorinated carbohydrate or a derivative thereof, such as sucralose, the method involves (i) reacting the carbohydrate or derivative thereof with a chlorinating agent to obtain a reaction mixture comprising said polychlorinated carbohydrate or derivative thereof and at least one under-chlorinated carbohydrate or derivative thereof, (ii) returning the at least one under-chlorinated carbohydrate or derivative thereof to a chlorinating step and further chlorinating the at least one under-chlorinated carbohydrate or derivative thereof to obtain the desired polychlorinated carbohydrate or derivative thereof; and (iii) optionally repeating steps (i) and (ii) “n” times where n?1. The polychlorinated carbohydrate or a derivative thereof is obtained in high yields.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 8, 2014
    Assignee: Lexington Pharmaceuticals Laboratories, LLC
    Inventors: William Randal Erickson, Stephen Craig Fields
  • Publication number: 20140065062
    Abstract: The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation enhancers, anti-microbial effects, anti-fugal effects, facilitation of diagnostic procedures. The invention further includes methods of treatment and diagnostic kits.
    Type: Application
    Filed: November 4, 2013
    Publication date: March 6, 2014
    Inventor: Bahram Memarzadeh
  • Patent number: 8664372
    Abstract: In preparing a glycoside compound from (a) a furanose compound or pyranose compound, and (b) an alcohol compound, a process for preparing a glycoside compound in which glycosidic bond locates selectively trans form relative to C-2 hydroxyl group, the process comprising using a furanose compound wherein the hydroxyl at the 2-position may have a substituent protected with a group A, or a pyranose compound which may have a substituent wherein R2 and R3 are the same or different and are each alkyl having 1 to 4 carbon atoms or aryl having or not having a substituent, or R2 and R3 are combined to form alkylene having 2 to 4 carbon atoms (the alkylene may be substituted with alkyl having 1 to 4 carbon atoms, or may have intervening phenylene), and m and n are each an integer of 0 or 1.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: March 4, 2014
    Assignee: Glytech, Inc.
    Inventor: Shigeru Yamago
  • Publication number: 20140051850
    Abstract: The invention relates to a method of crystallising lactose from a lactose-containing liquid comprising the steps of providing a lactose-containing liquid comprising less than 80% by weight total solids, providing an evaporator system that comprises a heat exchanger and an evaporation vessel, the heat exchanger comprising a tube or tubes that define a flowpath having an inlet and an outlet, heating the lactose-containing liquid in the heat exchanger to about 50 to about 90° C. such that the lactose-containing liquid passes along the flowpath by forced circulation or thermo-siphoning, concentrating the lactose-containing liquid in the evaporation vessel, to generate crystallised lactose in the lactose-containing liquid in the evaporator system.
    Type: Application
    Filed: October 10, 2011
    Publication date: February 20, 2014
    Inventors: Anthony James Styles, Paul Stephenson
  • Patent number: 8653256
    Abstract: The present invention relates a method of producing turanose using amylosucrase and a sweetener including the turanose. This method enables production of high-purity turanose through an enzymatic reaction occurring by treating a solution including only sucrose or a solution including fructose and sucrose with amylosucrase.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: February 18, 2014
    Assignee: Industry-Academia Cooperation Group of Sejong University
    Inventors: Sang-Ho Yoo, Ren Wang, Cheon-Seok Park
  • Publication number: 20140024820
    Abstract: The present invention relates to nucleic acid and amino acid sequences from Escherichia coli serogroup O126, coding for/representing a novel alpha-1,2-fucosyltransferase. The invention also provides uses and methods for using the alpha-1,2-fucosyltransferase to generate fucosylated products, such as oligosaccharides, (glyco)proteins, or (glyco)lipids, in particular oligosaccharides found in human milk, such as 2?-fucosyllactose.
    Type: Application
    Filed: July 19, 2013
    Publication date: January 23, 2014
    Applicant: Jennewein Biotechnologie GmbH
    Inventors: Julia Parkot, Eric Huefner, Stefan Jennewein, Lothar Elling, Leonie Engels
  • Patent number: 8633303
    Abstract: Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: January 21, 2014
    Assignee: Glycomimetics, Inc.
    Inventors: John L. Magnani, John T. Patton, Jr., Arun K. Sarkar, Sergei A. Svarovsky, Beat Ernst
  • Publication number: 20130303752
    Abstract: Immune function of an animal can be modulated by administration of a composition that includes algae meal or beta glucan. The algae meal can be made by growing Euglena using particular methods and conditions, including certain continuous, semi-continuous, fed-batch, and repeat batch methods in sterile fermenters. Euglena provides a form of beta glucan that is different from other organisms, where the beta glucan is predominantly unbranched beta-1,3-glucan. Use of algae meal and beta glucan produced by the disclosed processes can improve the wellbeing of an animal or human, and may augment or even replace the use of antibiotics in certain circumstances.
    Type: Application
    Filed: May 7, 2013
    Publication date: November 14, 2013
    Applicant: Algal Scientific Corporation
    Inventor: Algal Scientific Corporation
  • Patent number: 8575333
    Abstract: The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation enhancers, anti-microbial effects, anti-fugal effects, facilitation of diagnostic procedures. The invention further includes methods of treatment and diagnostic kits.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: November 5, 2013
    Inventor: Bahram Memarzadeh
  • Patent number: 8557976
    Abstract: Isolated microbial consortia capable of degrading chlorinated carbohydrates and a method to acclimatize microbes to degrade chlorinated carbohydrates under specific conditions of temperature and salt are described. Also described is a method for using microbial consortia to degrade chlorinated carbohydrates in a waste stream.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: October 15, 2013
    Assignee: Tate & Lyle Technology Limited
    Inventors: Chi-Li Liu, Travis Aaron Mahan, Edward Farley
  • Patent number: 8557793
    Abstract: The present invention relates to a theanine derivative, a preparation method thereof, and a use thereof for anti-acne treatment, having a selective inhibitory effect on Propionibacterium acnes in the skin.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: October 15, 2013
    Assignee: Amorepacific Corporation
    Inventors: Jae Won Yoo, Yu Na Yun, Seo Young Kim, Jin Young Lee, Jun Oh Kim, Jun Cheol Cho
  • Patent number: 8557784
    Abstract: The present invention provides a pharmaceutically acceptable compound, a pharmaceutical composition comprising the above-mentioned pharmaceutically acceptable compound. The pharmaceutically acceptable compound provided by the present invention is a salt of a basic group-containing morphinan derivative and a carboxyl group-containing glycyrrhizinic acid and has the ability to be used to manufacture medicaments for treating and/or preventing cough, ameliorating pains, treating respiratory system diseases, treating cardiovascular diseases and treating liver diseases.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: October 15, 2013
    Assignee: Standard Chem. & Pharm. Co., Ltd.
    Inventors: Chin-Tsai Fan, Cheng-Shun Lai, Wen-Yen Yeh, Yu-Ying Liu
  • Patent number: RE44778
    Abstract: Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: February 25, 2014
    Assignee: Glycomimetics, Inc.
    Inventors: John L. Magnani, John T. Patton, Jr., Arun K. Sarkar, Sergei A. Svarovsky, Beat Ernst