Polysaccharides Patents (Class 536/123.1)
  • Patent number: 10188608
    Abstract: A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: January 29, 2019
    Assignee: Covidien LP
    Inventors: Phillip Blaskovich, Rachit Ohri, Lan Pham
  • Patent number: 10058506
    Abstract: A tunable antimicrobial-loaded hydrogel formulation has a mechanical strength can be altered by changing the salt composition. The hydrogel formulation is preferably a Gellan film. The ion concentration in the gel material may be altered to obtain the desired gel strength. The hydrogel formulation is layered directly upon a skin area such as burnt skin. The hydrogel formulation includes a dosage of free antibiotic, such as the antibiotic is preferably vancomycin, for rapid release. The hydrogel formulation also includes microparticles and/or nanoparticles such as activated carbon powder that has adsorbed additional antibiotic. The particles are used to aid in attaining a timely or sustained release of the antibiotic drug.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: August 28, 2018
    Assignee: Brown University
    Inventors: Anita Shukla, Shashank Shukla
  • Patent number: 9834447
    Abstract: A printed energy storage device includes a first electrode, a second electrode, and a separator between the first and the second electrode. At least one of the first electrode, the second electrode, and the separator includes frustules, for example of diatoms. The frustules may have a uniform or substantially uniform property or attribute such as shape, dimension, and/or porosity. A property or attribute of the frustules can also be modified by applying or forming a surface modifying structure and/or material to a surface of the frustules. A membrane for an energy storage device includes frustules. An ink for a printed film includes frustules.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: December 5, 2017
    Assignee: PRINTED ENERGY PTY LTD
    Inventors: Vera N. Lockett, John G. Gustafson, Mark D. Lowenthal, William J. Ray
  • Patent number: 9562010
    Abstract: An isotope labeled asymmetric cross-linker is provided for the detection of cross-linked peptides. A cross-linking and mass spectrometry strategy, referred to as isotope tagging of interacting proteins (iTIP), improves the specificity of detecting cross-linked peptides and accurate identification of the interacting peptide sequences via the incorporation of isotopic signatures that are readily observed in the MS/MS spectrum. Isotope tagged peptides can be identified using mass spectrometry based on doublet peaks in a spectrum. Spectra can be subjected to database search strategies available for the sequencing of linear or non-cross-linked peptides.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: February 7, 2017
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Harsha P. Gunawardena, Xian Chen
  • Patent number: 9447133
    Abstract: The present invention provides synthetic Moraxella catarrhalis lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various M. catarrhalis serotype-specific oligosaccharide antigens or various core M. catarrhalis oligosaccharide structures or motifs corresponding to one or more of the three major serotypes and/or members within a given serotype. The oligosaccharides may be synthesized by a chemical assembly methodology relying on a limited number of monosaccharide and disaccharide building blocks. The invention further provides M. catarrhalis LOS-based immunogenic and immunoprotective compositions and antibodies derived therefrom for diagnosing, treating, and preventing infections caused by M. catarrhalis.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: September 20, 2016
    Assignee: VISTERRA, INC.
    Inventors: A. Stewart Campbell, Gregory Lohman, Obadiah J. Plante
  • Patent number: 9296795
    Abstract: Immunogenic polysaccharide-protein conjugates having a polysaccharide antigen (or its oligosaccharide fragment representing one or more antigenic epitopes) derived from a nosocomial pathogen conjugated to a staphylococcal surface adhesin carrier protein are used in immunogenic compositions to elicit antibody responses to both the polysaccharide antigen and the staphylococcal surface adhesion carrier protein. Such immunogenic compositions are used to immunize against diseases caused by Staphylococcal aureus, Staphylococcal epidermidis or other nosocomial pathogens.
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: March 29, 2016
    Assignees: WYETH HOLDINGS, LLC., INHIBITEX, INC.
    Inventors: Viliam Pavliak, Steven Morris Baker, Subramonia Padmanaba Pillai
  • Patent number: 9243078
    Abstract: A method to increase the molecular weight of wood mannans and xylans comprising aromatic moieties comprises the steps: a) obtaining mannan and/or xylan from wood, b) subjecting the mannan/xylan to oxidizing conditions to convert at least a fraction of the aromatic groups into radicals and reacting said radicals with each other to obtain complexes of mannan/xylan with increased molecular weight. The method is easy and cost efficient and enables to upgrade small wood mannans and xylans that are important in the pulp and paper industry into larger mannans and xylans and more defined structures which makes their isolation easier and application areas broader. Another advantage is that separation of mannans and xylans from mannans and xylans with bound aromatic groups is provided. The wood mannans and xylans with increased molecular weight can be used for the manufacture of barrier films in packages, for instance for oxygen, liquids and gas.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: January 26, 2016
    Assignee: Ecohelix AB
    Inventors: Gunnar Henriksson, Dimitri Areskogh, Petri Oinonen
  • Patent number: 9237764
    Abstract: The present invention relates to a method for preparation of the trisaccharide 6?-O-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6?-O-sialyllactose salts in pharmaceutical or nutritional compositions.
    Type: Grant
    Filed: February 21, 2011
    Date of Patent: January 19, 2016
    Assignee: Glycom A/S
    Inventors: Ignacio Figueroa Pérez, Ferenc Horváth, Gyula Dekany, Károly Ágoston, Ágnes Ágoston, István Bajza, Julien Boutet, Markus Hederos, Piroska Kovács-Pénzes, Lars Kröger, Christoph Röhrig, Andreas Schroven, Ioannis Vrasidas, Christian Risinger
  • Patent number: 9221898
    Abstract: An isolated or purified compound is provided, comprising A-GlcNAc[GlcNAc]-GalNAc-GalNAc-QuiNAc4NAc, wherein A is GlcNAc or Glc. There is further provided a vaccine based on such compound, having particular use to treat or prevent an infection caused by a Campylobacter organism. There is also provided an antibody or antisera against the compound, having particular use to diagnose the presence of an infection caused by a Campylobacter organism.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: December 29, 2015
    Assignee: The Governors of the University of Alberta
    Inventors: Christine Szymanski, Harald Nothaft
  • Patent number: 9096693
    Abstract: The invention describes a method for obtaining inulin which comprises: a) finely comminuting inulin-containing plant material, wherein particle sizes of the plant material are generated which are smaller than the size of the inulin-containing plant cells, b) suspending the finely comminuted plant material in a liquid, wherein inulin is released from the plant material and suspended in particulate form in the liquid, c) separating off plant particles from the liquid, wherein the inulin which is suspended in particulate form remains in the liquid, d) separating off the inulin which is suspended in particulate form from the liquid. The method is suitable in particular for obtaining inulin from artichoke roots.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: August 4, 2015
    Assignee: BAYER CROPSCIENCE AG
    Inventors: Günther Laufenberg, Friedrich Meuser
  • Patent number: 9045566
    Abstract: A method for the manufacture of an agarose separation gel: The method is characterized in comprising the steps of: i) providing a solution of agar, and ii) one, two or more substeps (ii.A, ii.B, ii.C etc) which each comprises desulphating thereby transforming agar to agarose having a degree of substitution of sulphate groups that is at most 75% of the degree of substitution of sulphate groups in native agar, iii) gelling the dissolved agar prior to step (ii) and/or securing so that the desulphated agar is in gel form at least after one or more of the substeps of step (ii), and imperatively after step (ii). An agarose separation gel that exhibits a. a plurality of methoxy groups each of which are at the same position as in native agar and with a degree of substitution in the range of 1-100% of the degree of substitution of native agar, and b. sulphate groups with a degree of substitution which is <75% of the degree of substitution for sulphate groups in native agar.
    Type: Grant
    Filed: April 29, 2008
    Date of Patent: June 2, 2015
    Assignee: Bio-Works Technologies AB
    Inventor: Göran Lindgren
  • Patent number: 9034844
    Abstract: The present invention relates to a process of synthesis of ?-sialyl oligosaccharides and in particular of 6?-sialyllactose and its salts comprising a step of coupling by Koenigs-Knorr reaction under conditions that allow its use on an industrial scale.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: May 19, 2015
    Assignee: INALCO S.P.A.
    Inventors: Giancarlo Tamerlani, Ilaria Lombardi, Debora Bartalucci, Andrea Danesi, Liana Salsini, Marco Manoni, Giovanni Cipolletti
  • Publication number: 20150128830
    Abstract: The present invention relates to an aqueous suspension of mineral pigment materials having high solids content, which contain dispersing agents and/or grinding agents based on renewable sources, and methods for preparing such a suspension and its use.
    Type: Application
    Filed: May 6, 2013
    Publication date: May 14, 2015
    Inventors: Patrick A.C. Gane, Matthias Buri, Samuel Rentsch, Cécile Ganneau
  • Patent number: 9028857
    Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprise the steps consisting of a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide and one cross-linking agent b) freezing the aqueous solution of step a) c) sublimating the frozen solution of step b). characterized in that step b) is performed before the cross-linking of the polysaccharide occurs in the solution of step a).
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: May 12, 2015
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Universite Paris 7—Denis Diderot
    Inventors: Catherine Le Visage, Didier Letourneur, Frederic Chaubet, Aude Autissier
  • Patent number: 9029530
    Abstract: Provided herein are processes for detecting oligosaccharides in a biological sample. In specific instances, the biological sample is provided from an individual suffering from a disorder associated with abnormal glycosaminoglycan accumulation.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: May 12, 2015
    Assignee: BioMarin Pharmaceutical Inc.
    Inventors: Brett E. Crawford, Jillian R. Brown, Charles A. Glass
  • Patent number: 9029136
    Abstract: The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: May 12, 2015
    Assignee: Glycosyn LLC
    Inventors: Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
  • Patent number: 9029350
    Abstract: This invention relates to the use of a biomaterial for the treatment, repair and/or enhancement of bodily tissue insufficiencies of the vocal chords, muscles, ligaments, cartilage, post-operative regions, sexual organs and/or weight supporting areas of the feet as well as other conditions of the bones and joints. The biomaterial for use in the invention may comprise an injectable bioresorbable polysaccharide composition wherein the polysaccharide may be succinochitosan glutamate. This invention also relates to the use of a biomaterial comprising an injectable bioresorbable polysaccharide composition in which resorbable particles may be in suspension, the said particles comprising or consisting essentially of chitin and/or chitosan, which may be free of any additional formulation modifying agents, and a process for manufacturing the same. The invention also includes the use of various medicaments in the biomaterial formulations to enhance the treatment of the affected area of the body.
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: May 12, 2015
    Assignee: Cutanea Life Sciences, Inc.
    Inventors: Robert J. Bitterman, Kimberley A. Forbes-McKean
  • Publication number: 20150125871
    Abstract: The present invention concerns a method for determining the impact of a production step or a purification step on the presence or nature of pro-inflammatory contaminating molecules in glucose polymers or the hydrolysates of same by using an in vitro test of inflammatory response using cell lines. It further concerns an optimised method of producing or purifying glucose polymers or the hydrolysates of same comprising an analysis of the pro-inflammatory contaminating molecules in glucose polymers or the hydrolysates of same and the selection of production or purification steps optimised with respect to the presence and nature of the pro-inflammatory contaminating molecules.
    Type: Application
    Filed: May 28, 2013
    Publication date: May 7, 2015
    Applicant: ROQUETTE FRERES
    Inventors: Sophie Duvet, Hela Hacine-Guerbi, Pierre Lanos, Fabrice Allain, Mathieu Carpentier, Agnes Denys
  • Publication number: 20150126706
    Abstract: 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.
    Type: Application
    Filed: January 7, 2015
    Publication date: May 7, 2015
    Inventors: GEERT-JAN BOONS, JUN GUO, XINGHAI NING, MARGARETHA WOLFERT
  • Patent number: 9018372
    Abstract: The invention relates to a bonding product comprising at least the polysaccharides T1 and T2, characterized in that a) the monosaccharides from which the polysaccharides T1 and T2 are constructed are partially or completely bonded to each other alpha-1,4-glycosidically and b) at least one of the polysaccharides T1 and/or T2 comprises at least one amino group and c) T1 and T2 are chemically bonded to each other covalently by at least one linker Z and d) T1 and/or T2 carries m groups -(L-A), wherein A is an active pharmaceutical ingredient and/or a fluorescence label, L is a second linker, by which T1 and/or T2 is covalently bonded to A, and m is an integer, which is 0 or at least 1.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: April 28, 2015
    Assignee: B. Braun Melsungen AG
    Inventors: Bernd Horst Meier, Iris Jankowiak-Meier, Nele Meier, Clara Meier
  • Publication number: 20150112056
    Abstract: The invention relates to mutant strains of the genus Sphingomonas which have a mutation in at least one gene encoding a protein involved in polyhydroxybutyrate (“PHB”) synthesis that allows the mutant strains to produce PHB-deficient Sphingans. The invention is also directed to a process for preparing a clarified Sphingan solution comprising heating aqueous Sphingan solution, in particular PHB-deficient Sphingan solution, to a clarification temperature of about 30° C. to about 70° C., and treating the solution with a clarification agent and enzymes. In addition, the invention is directed to a food or industrial product comprising a PHB-deficient and/or clarified Sphingan. One particular embodiment of the invention is directed to a clarified, PHB-deficient high-acyl gellan and the processes of making thereof.
    Type: Application
    Filed: October 15, 2014
    Publication date: April 23, 2015
    Inventors: Stan Bower, Ellen Burke, Nancy E. Harding, Yamini N. Patel, J. Carrie Schneider, Dagmar Meissner, Neil A. Morrison, Ralph Bezanson
  • Patent number: 9012413
    Abstract: The invention relates to FGF receptor-activating N-acyl octasaccharides having Formula (I), wherein: R1 is an O-alkyl group optionally replaced by one or more aryl or cycloalkyl groups, R2 is an OSO3? or hydroxyl group, R3 is an alkyl, cycloalkyl, or alkyl-cycloalkyl group, R4 is a disaccharide having Formula (II), R6 is a disaccharide having Formula (III), and R8 is a disaccharide having Formula (IV), where R5, R7, and R9 are OSO3? or hydroxyl groups. The invention further relates to the preparation of said octasaccharides and to the therapeutic use thereof.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: April 21, 2015
    Assignee: Sanofi
    Inventors: Pierre Alexandre Driguez, Philippe Duchaussoy, Pierre Fons, Corentin Herbert, Gilbert Lassalle
  • Patent number: 9005622
    Abstract: The present invention relates to enterococcal cell wall components and their uses in the prevention and therapy of bacterial infection.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: April 14, 2015
    Assignees: Forschungszentrum Borstel, Universitätsklinikum Freiburg
    Inventors: Johannes Hübner, Christian Theilacker, Otto Holst, Zbigniew Kaczynski
  • Publication number: 20150098987
    Abstract: An object of the present invention is to provide a trans-resveratrol derivative that resists isomerization to the cis-form. This object can be achieved by a method for producing a trans-resveratrol polysaccharide, the method comprising the step of bringing a trans-resveratrol glucoside into contact with sugar in the presence of ?-cyclodextrin glucanotransferase.
    Type: Application
    Filed: July 11, 2014
    Publication date: April 9, 2015
    Inventors: Hiroki HAMADA, Shinichi KOJIMA, Shoji TAKAHASHI, Chiemi MOMOTA
  • Publication number: 20150098921
    Abstract: Disclosed are compositions including dihydroxyalkyl substituted polygalactomannan, and the optional further substitution of such with cationic and/or hydrophobic moieties. Method of making such compositions is also disclosed as well as the use of such compositions in industrial applications, fabric laundering, and personal and household care.
    Type: Application
    Filed: October 2, 2014
    Publication date: April 9, 2015
    Inventors: Michael Albert Hermann FRANZKE, Xiaochun ZHANG, Gijsbert KROON
  • Patent number: 8993540
    Abstract: The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: March 31, 2015
    Assignee: University of Memphis Research Foundation
    Inventors: Warren O. Haggard, Scott P. Noel, Joel D. Bumgardner
  • Patent number: 8987230
    Abstract: The present invention provides a composition comprising a hyaluronic acid derivative having a crosslinking group(s) and a hydrophilic polysaccharide derivative having a hydrophobic group(s), wherein the hyaluronic acid derivative having a crosslinking group(s) is prepared by crosslinkage formation reaction in hyaluronic acid or a derivative thereof having a crosslinkable group(s) in the presence of the hydrophilic polysaccharide derivative wherein the hydrophilic polysaccharide derivative may have a crosslinkable group(s).
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: March 24, 2015
    Assignees: National University Corporation Tokyo Medical and Dental University, Chugai Seiyaku Kabushiki Kaisha
    Inventors: Kazunari Akiyoshi, Nobuyuki Morimoto, Tai Hirakura, Tsuyoshi Shimoboji
  • Patent number: 8986728
    Abstract: The present invention provides an implantable device having a biosoluble coating or a biosoluble body structure comprising a polyelectrolyte and a counterion and the methods of making and using the same.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: March 24, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Syed F. A. Hossainy, Mikael O. Trollsas, Lothar W. Kleiner
  • Publication number: 20150080826
    Abstract: The present invention relates to a substrate which comprises oligogalacturonides. More particularly, the present invention provides a disposable absorbent article which comprises the substrate having the oligogalacturonides. The present invention also provides a process for manufacturing a disposable absorbent article comprising the substrate.
    Type: Application
    Filed: August 19, 2014
    Publication date: March 19, 2015
    Inventors: Bruno Johannes EHRNSPERGER, Bernhard HANKE, Josef Peter GUGGENBICHLER, Gary Dean LAVON
  • Patent number: 8981079
    Abstract: A chlorinating agent such as a chloroiminium species is used to remove or neutralize tertiary acetamide present as a contaminant in a tertiary formamide solvent. Tertiary formamide solvent purified or treated in this manner can be used as a reaction vehicle for the chlorination of sucrose-6-acylates, thereby improving the yields of the desired sucralose-6-acylate (an intermediate in the production of sucralose).
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: March 17, 2015
    Assignee: Tate & Lyle Technology Limited
    Inventors: James Edwin Wiley, Jr., Mohamad R. Jaber
  • Publication number: 20150072396
    Abstract: Low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations for modifying biomolecules is provided. Compositions, methods, and kits relating to low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations are also provided.
    Type: Application
    Filed: March 1, 2012
    Publication date: March 12, 2015
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Kyle Gee, Upinder Singh, Scott Grecian, Scott Clarke
  • Publication number: 20150072888
    Abstract: The present invention relates to the use of N-linked glycan profiles of blood or blood component proteins as biomarkers for diagnosing diabetes mellitus and for monitoring the efficacy of anti-diabetic therapy. Specifically, the present invention relates to detecting changes in the amounts of N-linked glycans as diagnostic biomarkers for diabetes mellitus and as indicators of the efficacy of anti-diabetic therapy over time.
    Type: Application
    Filed: April 19, 2013
    Publication date: March 12, 2015
    Inventors: Hidehisa Asada, Diane McCarthy, Yoshiaki Miura, Taku Nakahara
  • Patent number: 8974799
    Abstract: The invention provides a process for preparing a conjugate of a S. aureus type 5 or type 8 capsular polysaccharide and a carrier molecule, comprising the steps of: (a) depolymerizing the capsular polysaccharide, to give a polysaccharide fragment; (b) oxidizing the fragment in order to introduce an aldehyde group into at least one saccharide residue in the fragment, to give an oxidized saccharide residue; and (c) coupling the oxidized saccharide residue to a carrier molecule via the aldehyde group, thereby giving the conjugate. The coupling in step (c) may be direct, or may be via a linker molecule. The invention also provides a conjugate obtained or obtainable by this process.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: March 10, 2015
    Assignee: Novartis AG
    Inventors: Francesco Berti, Paolo Costantino, Maria Rosaria Romano
  • Patent number: 8975387
    Abstract: Compositions of matter are provided that include chitosan and a modified carbohydrate. The modified carbohydrate includes a carbohydrate component and a cross linking agent. The modified carbohydrate has increased carboxyl content as compared to an unmodified counterpart carbohydrate. A carboxyl group of the modified carbohydrate is covalently bonded with an amino group of chitosan. The compositions of matter provided herein may include cross linked starch citrate-chitosan and cross linked hemicellulose citrate-chitosan, including foams thereof. These compositions yield excellent absorbency and metal chelation properties. Methods of making cross linked modified carbohydrate-chitosan compounds are also provided.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: March 10, 2015
    Assignee: North Carolina State University
    Inventors: Richard A. Venditti, Joel J. Pawlak, Abdus Salam, Khaled Fathy El-Tahlawy
  • Publication number: 20150065451
    Abstract: The document provides nutritional supplement compositions. For example, nutritional supplement compositions containing a potato polysaccharide preparation, methods for obtaining potato polysaccharide preparations, methods for making nutritional supplement compositions containing a potato polysaccharide preparation, and methods for increasing or decreasing expression of polypeptides involved with mitochondria activity or function are provided.
    Type: Application
    Filed: March 14, 2013
    Publication date: March 5, 2015
    Inventors: George B. Stefano, Richard Kream, Kirk J. Mantione
  • Publication number: 20150064331
    Abstract: A method and a system for preparing xylan and calcium carbonate, xylan, a cellulose fibre, and precipitated calcium carbonate. The method includes extracting xylan from cellulose fibres with sodium hydroxide to form a mixture containing cellulose fibres and an extract solution containing xylan; removing the cellulose fibres from the mixture to isolate the extract solution; adding carbon dioxide to the isolated extract solution to form a mixture containing a liquid brightener and precipitated xylan; separating the brightener from the mixture to isolate the precipitated xylan; adding calcium hydroxide to the separated brightener to form a mixture of precipitated calcium carbonate and liquid sodium hydroxide; and removing the sodium hydroxide from the mixture to isolate the calcium carbonate.
    Type: Application
    Filed: March 26, 2013
    Publication date: March 5, 2015
    Inventors: Björn Krogerus, Agneta Fuhrmann, Christiane Laine
  • Publication number: 20150065457
    Abstract: Described are methods for using cyclodextrin to treat, inhibit, prevent, ameliorate, or cure diabetes or conditions relating to diabetes.
    Type: Application
    Filed: April 12, 2013
    Publication date: March 5, 2015
    Applicant: L&F HEALTH LLC
    Inventors: Alessia Fornoni, Sandra Merscher-Gomez
  • Patent number: 8962824
    Abstract: Aspects of the invention provide compositions for use in the treatment galectin-dependent diseases. In particular, compositions comprising a selectively depolymerized, branched galactoarabino-rhamnogalacturonate whose backbone is predominantly comprised of 1,4-linked galacturonic acid (GalA) moieties, with a lesser backbone composition of alternating 1,4-linked GalA and 1,2-linked rhamnose (Rha), which in-turn is linked to any number of side chains, including predominantly 1,4-b-D-galactose (Gal) and 1,5-a-L-arabinose (Ara) residues.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: February 24, 2015
    Assignee: Galectin Therapeutics, Inc.
    Inventors: Eliezer Zomer, Peter G. Traber, Anatole A. Klyosov, Elena Chekhova
  • Publication number: 20150050282
    Abstract: The present invention relates to compounds derived from sugars which reproduce the epitopes of Shigella flexneri serotypes 3a and X and to the use thereof for the preparation of vaccine compositions. More specifically, the subject matter of the present invention relates to novel glycoconjugated compounds comprising oligosaccharides or polysaccharides described hereinafter, to the method for synthesizing these oligosaccharides or polysaccharides and glycoconjugates, to derivatives of these oligosaccharides or polysaccharides, to compositions containing same, and also to the use of the glycoconjugates for vaccination purposes. Finally, the present invention relates to methods for diagnosing a Shigella flexneri infection using one or more oligosaccharides or polysaccharides or conjugates thereof.
    Type: Application
    Filed: June 20, 2014
    Publication date: February 19, 2015
    Applicants: INSTITUT PASTEUR, Centre National De La Recherche Scientifique, Universite Paris Descartes
    Inventors: Laurence MULARD, Julien BOUTET, Catherine GUERREIRO, Farida NATO, Philippe SANSONETTI, Armelle PHALIPON
  • Patent number: 8957202
    Abstract: An enterosoluble and intestinal-enzyme-biodegradable material is provided. The enterosoluble and intestinal-enzyme-biodegradable material includes a modified amylopectin, wherein at least one of hydrogen atoms is replaced by —CO—(CH2)n—COOH (n is 2-4) and the modified amylopectin has an acid value of 35-180 mg KOH/g. The disclosure also provides a method for preparing an enterosoluble and intestinal-enzyme-biodegradable material.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: February 17, 2015
    Assignee: Industrial Technology Research Institute
    Inventors: Chien-Pang Wu, Jyh-Horng Wu, Su-Jane Lo
  • Publication number: 20150044301
    Abstract: A system is disclosed for preparing a hypodermic injection site comprising a visibility enhancer for an injection site and a post injection hypodermic puncture wound site. The present invention offers a number of significant improvements which advance the efficacy of the art, by: preventing unintentional hypodermic injection of medicines through un-sanitized or under-sanitized skin surfaces, thereby protecting patients from becoming inoculated with pathogenic microorganisms while receiving such injections; significantly improving the visibility of, and, the accurate visual location and bandaging of post-injection needle puncture entry wounds, thereby further reducing the risk of infection of such wounds; and, by reducing bleeding from such wounds, which, in turn, reduces healthcare worker exposure to blood-borne pathogens and reduces the generation of potentially infectious, biohazardous medical waste.
    Type: Application
    Filed: August 8, 2013
    Publication date: February 12, 2015
    Inventor: Hans Werner Bottesch
  • Publication number: 20150038685
    Abstract: An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Also described is a method for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 1 polysaccharide covalently linked to a carrier protein, the method including partial de-O-acetylation of the polysaccharide by mild hydrolysis in an alkaline pH buffer.
    Type: Application
    Filed: October 21, 2014
    Publication date: February 5, 2015
    Inventors: William P. Hausdorff, George Rainer Siber, Peter R. Paradiso, A. Krishna Prasad
  • Patent number: 8946407
    Abstract: Provided are a fructosylated mangiferin, a preparation method therefor and a use thereof, wherein the fructosylated mangiferin has a structural formula represented by the following formula (I), the method for preparing the fructosylated mangiferin includes adding a substance with fructosylating enzymatic activity to a transformed liquid containing mangiferin for biotransformation reaction, so as to convert the mangiferin into the fructosylated mangiferin, wherein the transformed liquid contains the mangiferin and a glycosyl donor; as well as a use of the fructosylated mangiferin in preparation of a medicament for treatment of tumor-related diseases.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: February 3, 2015
    Assignee: Nanjing University of Technology
    Inventors: Bingfang He, Xueming Wu, Jianlin Chu, Bin Wu, Sen Zhang, Pingkai Ouyang
  • Patent number: 8945568
    Abstract: Disclosed is a new and emerging serotype of Streptococcus pneumoniae designated serotype 6D, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal polysaccharide with the repeating unit?2) glucose 1 (1?3) glucose 2 (1?3) rhamnose (1?4) ribitol (5?phosphate. This new serotype may be included in pneumococcal vaccines.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: February 3, 2015
    Assignee: The UAB Research Foundation
    Inventors: Moon H. Nahm, In Ho Park
  • Publication number: 20150031532
    Abstract: The present invention relates to stabilized channel type cyclodextrin crystals. In particular the present invention relates to a method for producing stabilized channel type cyclodextrin crystals, stabilized channel type cyclodextrin crystal comprising a stabilizer, uses of said stabilized crystals and products comprising stabilized channel type cyclodextrin crystals.
    Type: Application
    Filed: March 13, 2013
    Publication date: January 29, 2015
    Applicant: Amphidex A/S
    Inventors: Kim Lambertsen Larsen, Ronnie Nielsen, Thuy Thanh Do
  • Publication number: 20150025234
    Abstract: The invention provides novel gangliosides and mixtures of novel gangliosides, and drug products containing the same. The invention also provides cells induced to over-express one or more gangliosides. The invention further provides methods for production of gangliosides, e.g., GM1, from cells in culture using, for example, bone marrow cells and neuroblastoma cells. Methods include the treatment of cells with neural induction media and chloroquine, or chloroquine alone in the case of, e.g., human bone marrow cells, neuraminidase or glucosamine, to induce the production of gangliosides, e.g., GM1, in the cells. Also provided are methods of long-term, high density culturing of cells without passaging to produce gangliosides, e.g., GM1. Methods of quantifying gangliosides, e.g., GM1 in cell culture are also provided.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 22, 2015
    Inventors: Vanessa RAGAGLIA, Vandana Madanlal Sharma
  • Publication number: 20150017699
    Abstract: The present invention is generally directed to internally functionalized graphene substrates, methods of making such substrates and methods of using such substrates. In one aspect, the present invention is a graphene substrate. The substrate comprises edge and non-edge regions. Organic or inorganic molecules are bound to the non-edge regions of the substrate, and the organic or inorganic molecules are present on the substrate edges at a population greater than about one molecule per 10,000 nm2.
    Type: Application
    Filed: July 9, 2014
    Publication date: January 15, 2015
    Applicant: NANOTECH BIOMACHINES, INC.
    Inventors: Jeffrey Alan McKinney, William Emerson Martinez
  • Patent number: 8933218
    Abstract: The present application describes a process for conjugating a PNAG which is less than 40% N-acetylated to a carrier protein.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: January 13, 2015
    Assignee: GlaxoSmithKline Biologicals s.a.
    Inventors: Ralph Leon Biemans, Pierre Duvivier, Tomas Maira-Litran
  • Publication number: 20150011748
    Abstract: A method is for the manufacture of aqueous solutions of alkali metal salt of carboxymethyl fructan. More specifically the method for the manufacture of aqueous solutions includes at least 20% by weight of alkali metal salt of carboxymethyl fructan having a degree of carboxymethyl substitution of at least 1.2.
    Type: Application
    Filed: February 7, 2013
    Publication date: January 8, 2015
    Applicant: ITALMATCH CHEMICALS SPA
    Inventors: Patrick Pierre Notté, Albert Firmin Devaux
  • Publication number: 20150007953
    Abstract: A process comprising treating a lignocellulosic material preferably pulp in the presence of a transition metal catalyst with a oxidizing agent selected from a group consisting of hydrogen peroxide, hypochlorite, hypochlorous acid and any combination thereof to form a treated lignocellulosic material having a viscosity equal to or less than about 17 cp and having reducing functional groups selected from the group consisting of aldehyde and aldehyde type functional groups at the C6 and C1 positions but predominating at the C1 position.
    Type: Application
    Filed: June 17, 2014
    Publication date: January 8, 2015
    Inventors: ZHENG TAN, DAMARIS LORENZONI, GOPAL GOYAL, SEN YANG