Disaccharides (e.g., Maltose, Sucrose, Lactose, Formaldehyde Lactose, Etc.) Patents (Class 536/123.13)
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Patent number: 7087746Abstract: Disaccharides of formula (I) are derived from a-maltosyl fluoride, wherein R1 and R2 are defined. Such disaccharides are useful as glycosyl donors in transglycosylation reactions catalyzed by glycoside-hydrolazes or in transfer reactions catalyzed by transglycosylases during the preparation of oligosaccharides or polysaccharides.Type: GrantFiled: July 26, 2002Date of Patent: August 8, 2006Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Lionel Greffe, Hugues Driguez
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Patent number: 7084131Abstract: A method for preparing a polydispersed saccharide composition in which a fructan-containing material is dissolved in water prior to partial enzymatic treatment of the fructans.Type: GrantFiled: December 12, 2002Date of Patent: August 1, 2006Assignee: Raffinerie Tirlemontoise S.A.Inventors: Leen De Leenheer, Karl Booten
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Patent number: 7041651Abstract: Provided is a composition and a method for increasing cellular uptake of bioactive agents, particularly those compounds termed “small molecules” into the cells of mammalian tissue, such as the epithelial cells of the mucosa.Type: GrantFiled: March 9, 2004Date of Patent: May 9, 2006Assignee: Aesgen, Inc.Inventors: Robert G. Petit, II, Edward C. Shinal
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Patent number: 7034006Abstract: The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiologically acceptable monomers and polymers (PE conjugates) manifest an unexpectedly wide range of pharmacological effects, including stabilizing cell membranes; limiting oxidative damage to cell and blood components; limiting cell proliferation, cell extravasation and (tumor) cell migratory behavior; suppressing immune responses; and attenuating physiological reactions to stress, as expressed in elevated chemokine levels.Type: GrantFiled: January 10, 2001Date of Patent: April 25, 2006Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Saul Yedgar, David Shuseyov, Gershon Golomb, Reuven Reich, Isaac Ginsburg, Abd-al-Roof Higazi, Moshe Ligumski, Miron Krimsky, David Ojcius, Benito Antonio Yard, Fokko Johannes van der Woude, Edit Schnitzer
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Patent number: 7001892Abstract: Pharmaceutical compositions comprising crystals of a pharmaceutically-acceptable crystal lattice component, and an active pharmaceutical ingredient different from and included within the crystal lattice component in a growth-sector specific orientation. The crystals are prepared using components and methods which yield crystals having suitable purity and efficacy for use in administering the active pharmaceutical ingredients to a patient. The crystals are typically combined with adjuvants such as excipients, diluents or carriers, and are preferably formulated into tablets, capsules, suspensions, and other conventional forms containing predetermined amounts of the pharmaceuticals. Also provided are methods for preparing the crystals, and methods for storing and administering the active pharmaceutical ingredient either included within the crystals or upon reconstitution of the crystals to a solution.Type: GrantFiled: June 12, 2000Date of Patent: February 21, 2006Assignee: Purdue Research FoundationInventors: Jean A. Chmielewski, Bart E. Kahr, Jerry Lewis
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Patent number: 6984636Abstract: The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to an antioxidant moiety which is either a superoxide dismutase (SOD) mimetic or a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.Type: GrantFiled: August 12, 2002Date of Patent: January 10, 2006Assignees: Medical Research Council, University of OtagoInventors: Michael P. Murphy, Robin A. J. Smith
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Patent number: 6984732Abstract: A composition for sweetening ingestable solids or liquids. The composition is compressed and comprises less than about 7.5 weight-% sucralose and one or more diluents. The composition is compressed at a pressure of greater than 2 pounds per square inch. A method of forming the composition and a system for delivering the composition are also provided.Type: GrantFiled: March 31, 2003Date of Patent: January 10, 2006Assignee: McNeil-PPC, Inc.Inventors: Steven Catani, Anne-Lise Lucas
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Patent number: 6953850Abstract: The invention provides collections of orthogonally-protected monosaccharides as universal building blocks for the synthesis of glycoconjugates of non-carbohydrate molecules, neo-glycoconjugates and oligosaccharides. This orthogonal protection strategy allows for the specific deprotection of any substituent ono the saccharide ring, and greatly facilitates targeted or library-focused carbohydrate-related syntheses. In particular, the invention provides a universal monosaccharide building block of General Formula (I) or General Formula (II) in which A is a leaving group; X is hydrogen, O, N or N3; X1 is hydrogen, —CH2O—, —CH2NH—, —CH3, —CH2N3 or —COO—; and B, C, D and E are protecting groups that can be cleaved orthogonally, and in which B, C, D and E are absent when X is hydrogen or N3, and E is absent when X1 is hydrogen, CH3 or N3.Type: GrantFiled: January 18, 2000Date of Patent: October 11, 2005Assignee: Alchemia Pty. Ltd.Inventors: Gyula Dekany, John Papagerogiou, Laurent Francois Bornaghi
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Patent number: 6943248Abstract: A crystalline form of sucralose, and a method of making it. The method involves continuously crystallizing sucralose from an aqueous solution by a process providing continuous removal and recirculation of the vessel contents, and providing a long residence time for sucralose in the system. The crystals thus formed are of a relatively low length/diameter ratio, have an unsymmetrical shape, and exhibit good stability. The larger crystals in particular are tapered as compared to the rod-like larger crystals in prior art product.Type: GrantFiled: April 30, 2003Date of Patent: September 13, 2005Assignee: Tate & Lyle Public Limited CompanyInventors: Steven J. Catani, Carolyn M. Merkel, Nicholas M. Vernon
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Patent number: 6936588Abstract: The present invention relates to a method for the production and use of enteral nutrients, particularly an enteral solution, wherein this method is distinguished by a particularly gentle processing, particularly of the carbohydrate components contained in the solution.Type: GrantFiled: October 10, 2003Date of Patent: August 30, 2005Assignee: Südzucker Aktiengesellschaft Mannheim/OchsenfurtInventors: Jörg Kowalczyk, Gunhild Kozianowski, Markwart Kunz, Matthias Moser
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Patent number: 6930180Abstract: The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine in a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also, a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins.Type: GrantFiled: February 1, 2002Date of Patent: August 16, 2005Assignee: Genencor International, Inc.Inventors: J. Bryan Jones, Benjamin G. Davis
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Patent number: 6897202Abstract: The object of the present invention is to provide a powdery product comprising crystalline ?-maltose monohydrate which is powderized by spray method, and has a high-solubility in aqueous solvents and a satisfactory handleability, and to its preparation and uses.Type: GrantFiled: August 21, 2002Date of Patent: May 24, 2005Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Takashi Shibuya, Toshiyuki Sugimoto, Toshio Miyake
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Patent number: 6894160Abstract: The invention relates to the industrial conversion of carbohydrates, alcohols, aldehydes or polyhydroxy compounds in aqueous phase. According to the invention a catalytic method is used for the conversion, using a metal catalyst consisting of polymer-stabilized nanoparticles. A catalyst of this type is not deactivated by the conversion reaction as long as the stabilizing interaction between the polymer and the nanoparticles is maintained.Type: GrantFiled: January 10, 2003Date of Patent: May 17, 2005Assignee: Sudzucker Aktiengesellschaft Mannheim/OchsenfurtInventors: Emine Capan, Marc Sascha Hahnlein, Ulf Prusse, Klaus-Dieter Vorlop, Alireza Haji Begli
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Patent number: 6891035Abstract: Process for bulk autoclaving of polysaccharides, wherein the process includes: a) dissolving the polysaccharides in an aqueous solution and mixing until a homogeneous solution is obtained; b) filling the resulting solution in at least one container; c) placing the filled container(s) including the solution in an autoclave; d) placing a sensor in at least one of the containers; and e) autoclaving the filled containers.Type: GrantFiled: July 1, 2002Date of Patent: May 10, 2005Assignee: Biovitrum ABInventor: Olle Ljungquist
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Patent number: 6863737Abstract: A crystalline mixture solid containing maltitol having an oil absorptivity of 0.1 to 6.9 wt % and a bulk density of 0.60 to 0.75 g/cc when it is ground and classified to ensure that at least 70 wt % of the obtained particles should have a particle size of 16 to 50 mesh and a process for producing a crystalline mixture solid containing maltitol, comprising introducing air bubbles into a maltitol aqueous solution. According to this process, a crystalline mixture solid containing maltitol having high solubility and almost no moisture absorption is produced at a high work efficiency and a low cost in a short period of time.Type: GrantFiled: July 3, 2001Date of Patent: March 8, 2005Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo KenkyushoInventors: Ryuzo Ueno, Akihiko Tabata, Junya Honda, Yojiro Furukawa
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Patent number: 6861512Abstract: The geometric isomers of olefins and olefinic compounds are separated by means of liquid chromatography using a stationary phase comprising an organosilane with a pendant aliphatic functional group such as C18 and a mobile phase which includes an additive comprising alkanes and alkenes.Type: GrantFiled: March 1, 2001Date of Patent: March 1, 2005Assignee: Eisai Co., Ltd.Inventors: Lily Lu, John D. Orr
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Patent number: 6852707Abstract: By using xylobiose or xylooligosaccharide containing xylobiose as a main ingredient in place of lactulose, there is provided a blood ammonia lowering agent, a therapeutic agent of hyperammonemia or a therapeutic agent of hepatic encephalopathy that need be adminstered in smaller doses and which have no concern over side effects. Lactulose conventionally used as such drugs has to be administered in high doses and involves a safety problem when administered to patients with galactosemia or diabetes mellitus. The drug of the invention which contains xylobiose as a main ingredient solves these problems.Type: GrantFiled: December 9, 1999Date of Patent: February 8, 2005Assignee: Suntory LimitedInventors: Yoshinobu Kiso, Taeko Iino, Shinzo Kato
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Publication number: 20040254366Abstract: The described invention relates to the new compound “sucrose-octosulphate salified with silver” usefully applicable in the prevention and cure of infections by micro-organisms of bacterial, fungal, viral and/or of yeast origins and in the promotion of tissue repair. The silver salts of sucrose octosulphate, subject of the invention have in fact been demonstrated to possess antimicrobial activities even higher than that of known silver compounds. These properties therefore make them particularly appropriate for use in different pathological or paraphysiological conditions of the skin, of the epithelia and of the mucosa both intact and lesioned.Type: ApplicationFiled: April 9, 2004Publication date: December 16, 2004Inventors: Gabriella Calderini, Marco Prosdocimi, Claudio Antico, Giuliana Miglierni, Danilo Casadei Messari
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Patent number: 6831172Abstract: Cross-linked hyaluronic acids produced by the reaction of the carboxylic acid groups of hyaluronic acid and a polyamine and the sulfated and hemisuccinylated derivates thereof. The cross-linked hyaluronic acids are useful for various pharmaceutical and medical purposes.Type: GrantFiled: June 18, 2001Date of Patent: December 14, 2004Assignee: Farmila-Thea Farmaceutici S.p.A.Inventors: Rolando Barbucci, Roberto Rappuoli
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Publication number: 20040241811Abstract: An enzymatic process to obtain 4-O-&bgr;-D-galactopyranosyl-D-xylose useful in compositions or solutions in the in vivo evaluation of intestinal lactose activity in humans, that comprises the steps of preparing a reaction mixture of D-xylose, a &bgr;-D-galactopyranoside and a reaction medium that comprises water buffered to a pH between 5.0 and 9.0; adding 10 to 1,000 units of &bgr;-D-galactosidase per gram of &bgr;-D-galactopyranoside; subjecting the reaction mixture to a reaction or a temperature between a temperature higher than the freezing point of the reaction mixture and 45° C., for 2 to 48 hours; for the reaction by deactivation of the &bgr;-D-galactosidase; and to isolate and crystallize the fractions that contain 4-O-&bgr;-D-galactopyranosyl-D-xylose from a crystallization mixture selected between mixtures of acetone/methanol in a ratio between 5/1 to 20/1 and mixtures of acetone/water in a ratio between 5/1 to 20/1.Type: ApplicationFiled: December 17, 2003Publication date: December 2, 2004Inventors: Francisco Javier Canada Vicinay, Guillerno Corrales Morales, Alfonso Fernandez-Mayorales Alvarez, Manuel Martin Lomas, Juan Jose Aragon Reyes
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Patent number: 6821547Abstract: The present invention is directed to a process and product by process for preparing a carbohydrate polymer which comprises polymerizing a sugar at a temperature below the point of substantial decomposition thereof and under reduced pressure in the presence of a catalytic effective amount of an organic acid selected from the group consisting of a monocarboxylic acid, a lactone of a monocarboxylic acid and arylol, while removing water formed during said polymerization, said organic acid being non-volatile and having only one acidic functionality and having no amino groups thereon.Type: GrantFiled: April 4, 2002Date of Patent: November 23, 2004Assignee: Danisco USA, Inc.Inventors: Pankaj Shah, Håkan Gros, Bengt Lindholm
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Publication number: 20040220398Abstract: A crystalline form of sucralose, and a method of making it. The method involves continuously crystallizing sucralose from an aqueous solution by a process providing continuous removal and recirculation of the vessel contents, and providing a long residence time for sucralose in the system. The crystals thus formed are of a relatively low length/diameter ratio, have an unsymmetrical shape, and exhibit good stability. The larger crystals in particular are tapered as compared to the rod-like larger crystals in prior art product.Type: ApplicationFiled: April 30, 2003Publication date: November 4, 2004Inventors: Steven J. Catani, Carolyn M. Merkel, Nicholas M. Vernon
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Patent number: 6812342Abstract: The present invention is directed to the field of organic chemistry in general and specifically to the preparation of hydrophobic derivatives of cyclic ADP ribose. One form of the present invention is the composition of one or more hydrophobic derivatives of cyclic ADP ribose. In another form of the present invention, a method for preparing a hydrophobic composition is described. Compositions of the present invention are useful for the study of in vivo calcium metabolism.Type: GrantFiled: June 20, 2002Date of Patent: November 2, 2004Assignee: Board of Regents, The University of Texas SystemInventor: Wen Hong Li
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Patent number: 6809198Abstract: The present invention provides an improved form of sucralose and a process for making it.Type: GrantFiled: August 1, 2003Date of Patent: October 26, 2004Assignee: Tate & Lyle Public Limited CompanyInventors: Fiesal El Kabbani, Amal Brohmi, Christian Heiss, Juan Navia, Steven J. Catani
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Publication number: 20040209841Abstract: The object of the present invention is to provide a composition of metal ion compound whose inherent and unsatisfactory properties for its industrial application such as deliquescence, reducing power, oxidizing power, low solubility in water, etc., are improved; and their preparation and uses. The present invention solves the above object by providing an associate of trehalose or maltitol and a metal ion compound or bittern component, and their preparation and uses.Type: ApplicationFiled: February 10, 2004Publication date: October 21, 2004Inventors: Kazuyuki Oku, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
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Publication number: 20040191400Abstract: A composition for sweetening ingestable solids or liquids. The composition is compressed and comprises less than about 7.5 weight-% sucralose and one or more diluents. The composition is compressed at a pressure of greater than 2 pounds per square inch. A method of forming the composition and a system for delivering the composition are also provided.Type: ApplicationFiled: March 31, 2003Publication date: September 30, 2004Inventors: Steven Catani, Anne-Lise Lucas
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Publication number: 20040181054Abstract: The present invention provides a process for preparing a sugar chain asparagine derivative. According to the process, various isolated sugar chain asparagine derivatives useful in the field of the development of pharmaceuticals and the like can be conveniently obtained in a large amount as compared to that of the prior art. The present invention also provides a process for preparing a sugar chain asparagine and a process for preparing a sugar chain via a step for preparing a sugar chain asparagine derivative. The present invention further provides a novel sugar chain asparagine derivative, a sugar chain asparagine and a sugar chain.Type: ApplicationFiled: December 18, 2003Publication date: September 16, 2004Inventors: Yasuhiro Kajihara, Ken Sasaki
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Publication number: 20040176317Abstract: The invention concerns disaccharides of formula (I) derived from &agr;-maltosyl fluoride, wherein R1 and R 2 are such as defined in Claim 1. Said disaccharides are useful as glycosyl donors in transglycosylation reactions catalysed by glycoside-hydrolases or in transfer reactions catalysed by transglycosylases during the preparation of oligosaccharides or polysaccharides.Type: ApplicationFiled: January 8, 2004Publication date: September 9, 2004Inventors: Lionel Greffe, Hugues Driguez
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Patent number: 6780990Abstract: A hydrogenated starch hydrolysate having the following saccharide contents (based on the solids content of the hydrogenated starch hydrolysate): A.<8 wt.-% of hydrogenated monosaccharides (DP=1); B.<41 wt.-% of hydrogenated disaccharides (DP=2); C.<15 wt.-% of hydrogenated trisaccharides (DP=3); D.<30 wt.-% of hydrogenated quat- to deca-oligosaccharides (DP=4 to 10); and E. from about 14 to about 38 wt.-% of hydrogenated undeca- or greater polysaccharides (DP≧11); and hard boiled candies which are produced from the hydrogenated starch hydrolysate.Type: GrantFiled: May 14, 2001Date of Patent: August 24, 2004Assignee: SPI Polyols, Inc.Inventor: Anh Si Le
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Publication number: 20040132989Abstract: The present invention relates to improved methods of purification of sugars and in particular to a method of preparing lactose. A low purity lactose source such as whey is subjected to a first demineralisation step involving either ion-exchange or the addition of divalent metal cations, followed by a second demineralisation step where alcohol is added. The invention also relates to lactose produced by this method and produts comprising lactose produced by this method.Type: ApplicationFiled: February 6, 2004Publication date: July 8, 2004Inventors: Estelle V. Lifran, Robert W. Sleigh, Robert L. Johnson, Robert J. Steele, James A. Hourigan, Sean M. Dalziel
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Patent number: 6755914Abstract: A crystalline mixture solid composition comprising &agr;-D-glucopyranosyl-1,1-mannitol (GPM), &agr;-D-glucopyranosyl-1,6-sorbitol (GPS-6) and a small amount of &agr;-D-glucopyranosyl-1,1-sorbitol (GPS-1) and a production process therefor. The above crystalline mixture solid composition is produced by mixing a hydrophilic solvent with a solid composition or aqueous solution comprising 50 to 80 wt % of GPM, 1 to 50 wt % of GPS-6 and 0.01 to 20 wt % of GPS-1, separating solid matter from a liquid, and removing water and the solvent from the solid matter and can be obtained as a thin scale crystal.Type: GrantFiled: January 16, 2002Date of Patent: June 29, 2004Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo KenkyushoInventors: Ryuzo Ueno, Akihiko Tabata, Junya Honda, Yojiro Furukawa, Sho Arai
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Patent number: 6746541Abstract: A crystalline mixture solid composition which has almost no hygroscopicity, is easy to handle and dissolve and hardly worn by abrasion, and comprises &agr;-D-glucopyranosyl-1,1-mannitol and &agr;-D-glucopyranosyl-1,6-sorbitol and may further comprise &agr;-D-glucopyranosyl-1,1-sorbitol in a certain case is obtained in an extremely short period of time by a power-saving and labor-saving process with a small-scale apparatus. A composition which comprises 20 to 75 wt % of &agr;-D-glucopyranosyl-1,1-mannitol, 23 to 70 wt % of &agr;-D-glucopyranosyl-1,6-sorbitol and 2 to 25 wt % of &agr;-D-glucopyranosyl-1,1-sorbitol and is in a crystalline mixture solid state or has a specific surface area of 0.07 to 0.1 m2/g, and a composition which comprises 30 to 75 wt % of &agr;-D-glucopyranosyl-l,1-mannitol, 25 to 70 wt % of &agr;-D-glucopyranosyl-1,6-sorbitol and has a specific surface area of 0.07 to 0.1 m2/g.Type: GrantFiled: October 12, 2001Date of Patent: June 8, 2004Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo KenkyushoInventors: Ryuzo Ueno, Akihiko Tabata, Junya Honda, Yojiro Furukawa, Sho Arai
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Publication number: 20040092732Abstract: Dextrins are prepared by hydrolyzing starch with an enzyme that consists essentially of a beta-amylase enzyme. The product prepared thereby will include a dextrin, such as beta-limit dextrin. Upon ultrafiltration of this product, a dextrin-rich fraction may be recovered. If desired, the dextrin-rich fraction may be further purified via diafiltration. Retrograded amylose may be separated from the product of enzymatic hydrolysis.Type: ApplicationFiled: October 28, 2003Publication date: May 13, 2004Applicant: Grain Processing CorporationInventors: Richard L. Antrim, Clark P. Lee
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Publication number: 20040082537Abstract: The object of the present invention is to provide a powdery product comprising crystalline &bgr;-maltose monohydrate which is powderized by spray method, and has a high-solubility in aqueous solvents and a satisfactory handleability, and to its preparation and uses.Type: ApplicationFiled: August 22, 2003Publication date: April 29, 2004Inventors: Takashi Shibuya, Toshiyuki Sugimoto, Toshio Miyake
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Patent number: 6727357Abstract: Compositions comprising alkoxylated lipophilic polyol compounds, e.g., ehtoxylated, esterified methyl glucosides, are disclosed wherein at least 5% of the polyol derivatives have about three moles of the lipophilic substituent per mole of polyol. Quite advantageously, the disclosed polyol derivatives can be dissolved into aqueous solutions to provide liquid thickeners suitable for thickening surfactant-containing compositions, e.g., shampoos, at cold processing temperatures.Type: GrantFiled: March 18, 2003Date of Patent: April 27, 2004Assignee: The Lubrizol CorporationInventors: Stuart Barry Polovsky, Carmella A. Barbeito, Wing Kin Li, Edward F. Diantonio, Russell Lowell Kreeger
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Patent number: 6723843Abstract: The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.Type: GrantFiled: August 30, 2002Date of Patent: April 20, 2004Assignee: Alchemia PTY LTDInventors: Istvan Toth, Gyula Dekany, Barry Kellam
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Patent number: 6723497Abstract: A dehydrated composition is provided that includes freeze-dried platelets. The platelets are loaded with trehalose which preserves biological properties during freeze-drying and rehydration. The trehalose loading is conducted at a temperature of from greater than about 25° C. to less than about 40° C., most preferably at 37° C., with the loading solution having trehalose in an amount from about 10 mM to about 50 mM. These freeze-dried platelets are substantially shelf-stable and are rehydratable so as to have a normal response to an agonist, for example, thrombin, with virtually all of the platelets participating in clot formation within about three minutes at 37° C.Type: GrantFiled: April 5, 2001Date of Patent: April 20, 2004Assignee: The Regents of the University of CaliforniaInventors: Willem F. Wolkers, John H. Crowe, Fern Tablin, Ann E. Oliver, Naomi J. Walker, Nelly Tsvetkova
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Patent number: 6723704Abstract: A glycosphingolipid having a sugar chain containing &agr;-glucosamine and &bgr;-glucosamine is disclosed. Such glycosphingolipid is advantageous in that possibly being manufactured in a facile and inexpensive manner, and that exhibiting moisturizing effect and immuno-enhancing activity.Type: GrantFiled: June 29, 2001Date of Patent: April 20, 2004Assignees: Kibun Food Chemifa Co., Ltd., The Kitasato InstituteInventors: Kazuyoshi Kawahara, Katsumi Murata
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Publication number: 20040064853Abstract: The invention relates to tissue specific promoters which can be used in plants for one or more of the following purposes: a. altering carbohydrate metabolism b. preventing memory substance loss c. expression of an invertase inhibitor d. expression of a fructosyl transferase e. expression of a levan sucrase f. expression of genes coding for transported proteins for N-compounds g. expression of characteristics which increase resistance/tolerance with respect to pathogens.Type: ApplicationFiled: September 15, 2003Publication date: April 1, 2004Inventors: Reinhard Hehl, Dorothee Kloos, Dietmar Jurgen Stahl
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Patent number: 6699846Abstract: Methods for treating diseases or conditions modulated or ameliorated by nitric oxide, particularly ischemia and reperfusion injury, are provided, using glycolipids structurally related to monophosphoryl lipid A but with notable reduction in proinflammatory and pyrogenic activity.Type: GrantFiled: March 14, 2001Date of Patent: March 2, 2004Assignee: Corixa CorporationInventors: Gary T. Elliott, David Johnson, Patricia Weber, Greg Sowell
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Publication number: 20040039194Abstract: The invention relates to a method of crystallizing maltitol from a maltitol solution by supersaturating the solution in respect of maltitol and crystallizing the maltitol from the solution. In the process of the invention, the maltitol-containing solution is brought to a supersaturated state, and the solution is subjected to evaporation, until a crystallization mass is obtained which has a crystal yield of 1 to 80% on maltitol, and a dry solids content of over 50%. After bringing the solution to a supersaturated state, the solution is preferably seeded by adding maltitol seed crystals. In one embodiment of the invention, additional feed liquid is added during the crystallization by evaporation.Type: ApplicationFiled: June 16, 2003Publication date: February 26, 2004Inventors: Juha Nurmi, Olli-Pekka Eroma, Heikki Heikkila, Johanna Nygren
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Publication number: 20040030124Abstract: This invention relates to a crystallization process for sucralose in which a mother liquor is obtained by separating crystalline sucralose from the remaining liquid. A portion of this mother liquor is returned to the same crystallization stage; the amount returned is adjusted so as to maintain the overall related substances level in the process below levels at which yield declines significantly.Type: ApplicationFiled: August 6, 2002Publication date: February 12, 2004Inventors: Steven J. Catani, Mark R. Huber, Nicholas M. Vernon
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Publication number: 20040024200Abstract: The present invention provides an improved form of sucralose and a process for making it.Type: ApplicationFiled: August 1, 2003Publication date: February 5, 2004Inventors: Fiesal El Kabbani, Amal Brohmi, Christian Heiss, Juan Navia, Steven J. Catani
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Patent number: 6683063Abstract: The invention provides methods of preventing and treating pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin and related conditions in a patient by administering to the patient antiendotoxin compounds by inhalation.Type: GrantFiled: June 11, 2002Date of Patent: January 27, 2004Assignee: Eisai Co., Ltd.Inventors: Daniel P. Rossignol, Mary W. Vermeulen
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Patent number: 6680048Abstract: Cellobiose esters and particularly &agr; cellobiose octanonanoate has been found able to structure water-immiscible liquids well, and in particular can produce clear structured emulsions. However, such emulsions tend to lose clarity or structural strength during storage. Deviating from &agr;-cellobiose octanonanoate can result in impaired clarity and/or impaired hardness of emulsion sticks. However, acylated cellobiose which contains acyl substituents of formula —O—CO—R in which R represents an n-octyl residue and the percentage Y of the nonanoate acyl substituent —O—CO—R at the anomeric carbon is at least 60% and the percentage A of &agr; anomer is greater than the anomer and not higher than A=74.5 +0.2Y when Y is up to 92% and not higher than A=161−0.74Y when Y is greater than 92% offers the production of sticks combining structurant stability with product clarity and hardness.Type: GrantFiled: October 17, 2001Date of Patent: January 20, 2004Assignee: Unilever Home & Personal Care USA, a division of Conopco, Inc.Inventors: Lynda Grainger, Kathryn Elizabeth Gransden, Andrew Hopkinson, Adam Jan Kowalski, Nicholas Webb, Michael Stephen White
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Publication number: 20040006222Abstract: The invention relates to a separation process of fractionating a solution comprising betaine and sucrose by subjecting said solution to chromatographic fractionation and nanofiltration and recovering a fraction enriched in betaine and optionally a fraction enriched in sucrose. The solution to be fractionated in accordance with the present invention is typically a sugar beet-derived solution, for instance a molasses solution.Type: ApplicationFiled: February 25, 2003Publication date: January 8, 2004Applicant: Finnfeeds Finland OyInventors: Hannu Paananen, Heikki Heikkila, Outi Puuppo, Hannu Koivikko, Kaj-Erik Monten, Mika Manttari, Marianne Nystrom
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Publication number: 20040006177Abstract: The present invention is to provide means of inhibiting chemical changes in unsaturated compounds by radical reactions through inhibition of radical formation in such an unsaturated compound: The present invention attains such an objective by providing an agent which comprises trehalose as an effective ingredient to form an association product between trehalose and an unsaturated compound.Type: ApplicationFiled: March 19, 2003Publication date: January 8, 2004Inventors: Kazuyuki Oku, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
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Publication number: 20040005589Abstract: The invention is directed to novel enzymes that convert sucrose to isomaltulose. More particularly, the present invention discloses novel sucrose isomerases, polynucleotides encoding these sucrose isomerases, methods for isolating such polynucleotides and nucleic acid constructs that express these polynucleotides. Also disclosed are cells, including transformed bacterial or plant cells, and differentiated plants comprising cells, which contain these sucrose isomerase-encoding polynucleotides, as well as extracts thereof. Methods of producing isomaltulose are also disclosed which use the polypeptides, polynucleotides, cells, cell extracts and plants of the invention.Type: ApplicationFiled: February 27, 2003Publication date: January 8, 2004Inventors: Robert George Birch, Luguang Wu
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Publication number: 20040002597Abstract: The invention relates to the industrial conversion of carbohydrates, alcohols, aldehydes or polyhydroxy compounds in aqueous phase. According to the invention a catalytic method is used for the conversion, using a metal catalyst consisting of polymer-stabilized nanoparticles. A catalyst of this type is not deactivated by the conversion reaction as long as the stabilizing interaction between the polymer and the nanoparticles is maintained.Type: ApplicationFiled: January 10, 2003Publication date: January 1, 2004Applicant: SUDZUCKER AKTIENGESELLSCHAFTInventors: Emine Capan, Marc Sascha Hahnlein, Ulf Prusse, Klaus-Dieter Vorlop, Alireza Haji Begli
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Patent number: RE39245Abstract: The present invention relates to simplified synthesis, new carbohydrate-based products and practical use of different carbohydrate-based products. Examples of these are (Gal?1-3Gal), GlcNAc?1-3Gal, ?- or ?-glycosides thereof, Gal?1-3Gal- containing tri-, or higher oligosaccharides, ?- or ?-glycosides thereof, GlcNAc?1-3Gal containing tri-, tetra-, or higher oligosaccharides, and derivatives and/or ?- or ?-glycosides thereof, Gal?1-3GalGlcNAc?1-3Gal, ?- or ?-glycosides thereof, Gal?1-3Gal?1-4GlcNAc?1-3Gal?1-4Glc, or other higher oligosaccharides containing the Gal?1-3Gal-structure, ?- or ?-glycosides thereof, modified carbohydrates, di-, tri-, oligo-, or polyfunctional products containing carbohydrate structures, and the use of the products for synthesis, affinity purification, diagnostic applications and therapy.Type: GrantFiled: December 23, 1996Date of Patent: August 22, 2006Assignee: Procur ABInventor: Kurt Nilsson