Nitrogen Containing Hetero Ring (e.g., Morpholine, Etc.) Patents (Class 536/31)
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Patent number: 9914745Abstract: Morpholino-based oligomers suitable as antisense agent comprising modifications of phosphorodiamidate backbone or modification with 5-substituted pyrimidines of morpholino compound that is soluble in culture medium and sufficient for cell penetration thereby eliminating the need for injecting into the cells. Monomers comprising the said oligomers and its method of manufacture, method of manufacture of the said oligomers and its dye, fluorophore, drug, biomolecule conjugate wherein the said oligomers find different end use but not limited to regulation of gene expression, tissue culture with improved transfection efficiency and related studies on cellular transfection.Type: GrantFiled: August 10, 2010Date of Patent: March 13, 2018Assignee: INDIAN ASSOCIATION FOR THE CULTIVATION OF SCIENCEInventors: Surajit Sinha, Sankha Pattanayak, Sibasish Paul, Bappaditya Nandi
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Patent number: 9580451Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:Type: GrantFiled: January 26, 2015Date of Patent: February 28, 2017Assignees: California Institute of Technology, Children's Hospital of Los AngelesInventors: Carl M. Blumenfeld, Harry B. Gray, Robert H. Grubbs, Karn Sorasaenee
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Publication number: 20150076046Abstract: An anion adsorbent of an embodiment includes a support and a triazine hydrochloride structure that is bound to the support.Type: ApplicationFiled: August 26, 2014Publication date: March 19, 2015Applicant: Kabushiki Kaisha ToshibaInventors: Yumiko SEKIGUCHI, Tomohito IDE, Hideyuki TSUJI
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Publication number: 20150025169Abstract: The invention pertains to an oligomer or polymer substituted by one or more bisacylphosphine oxide moieties, characterized in that said bisacylphosphine oxide moiety is linked via the phosphorous atom, optionally via a spacer group, to the oligomer or polymer backbone; as well as to specifically functionalized bisacylphosphine oxides, suitable to prepare said polymers or oligomers.Type: ApplicationFiled: October 1, 2014Publication date: January 22, 2015Applicant: BASF SEInventors: Hansjorg Grutzmacher, Timo Ott, Kurt Dietliker
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Publication number: 20140186415Abstract: A polymer composition including a polymer having a hydroxyl group and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group. A polymer material is also provided, including a polymer composition which includes a polymer having a hydroxyl group, and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group.Type: ApplicationFiled: December 18, 2013Publication date: July 3, 2014Applicant: Industrial Technology Research InstituteInventors: Ting-Yu SHIH, Tse-Min TENG, Chia-Chun WANG, Yu-Hua CHEN, Jui-Hsiang CHEN, Mei-Ju YANG, Shu-Fang CHIANG, Yen-Chun CHEN, Chia-Ni CHANG
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Publication number: 20140114058Abstract: The invention relates to substantially photochemically or thermally cross-linked polysaccharide derivatives in which the OH groups as OR groups have been esterified or converted into carbamate (urethane) or mixtures thereof and that do not contain photopolymerisable functional groups prior to the cross-linking. They can be used as carrier materials for the chromatographic separation of enantiomers.Type: ApplicationFiled: December 20, 2013Publication date: April 24, 2014Applicant: NOVARTIS AGInventors: Eric FRANCOTTE, Tong ZHANG
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Publication number: 20140079663Abstract: The invention relates to inhibitory compounds of a p38 MAP kinase having a structure of type (I)-(VII) which can be used for the treatment or prophylaxis of adhesion. Pharmaceutical compositions are disclosed containing an effective amount of the substance SB203580 or one or more of the conjugated compounds of type (I)-(VII) or a combination thereof, and a pharmaceutically acceptable carrier, a diluent or an excipient. Also disclosed is the use of the substance SB203580 as an agent having anti-adhesion activity. Also disclosed is a method for the prophylaxis and/or treatment of a disease or a condition in which there is a possibility of the formation and/or growth of adhesions, which makes it possible to dispense with the additional administration of a preparation in the post-operative period.Type: ApplicationFiled: November 18, 2013Publication date: March 20, 2014Applicant: Joint Stock Company "Pharmasyntez"Inventors: Mikhail Gennadievich Shurygin, Irina Aleksandrovna Shurygina
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Patent number: 8551767Abstract: A sensor for detection of target nucleic acid comprising (a) a semiconductor nanostructure; and (b) a nucleic acid detection probe immobilized on the semiconductor nanostructure capable of hybridizing with the target nucleic acid, the detection probe comprising a polymer with a substantially non-ionic backbone.Type: GrantFiled: November 20, 2008Date of Patent: October 8, 2013Assignees: Agency of Science, Technology and Research, BCI (Biochip Innovations), SimemsInventors: Guojun Zhang, Huiyl Jay Chua, Ru Ern Chee, Narayanan Bala Subramanian, Ross Barnard, Uppili Raghavan
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Publication number: 20130202549Abstract: The disubstituted piperazine analogs (DPAs) derivative compound and DPAs amine complex compound disclosed in the present aspects have characterized by presented pharmaceutics having functions to improve lipolysis, such as inhibiting obesity hyperlipidemia, and atherosclerosis.Type: ApplicationFiled: September 6, 2012Publication date: August 8, 2013Inventor: Ing-Jun Chen
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Patent number: 8497370Abstract: A series of amine salts including a structure of formula (I) and formula (III) have provided. In formula I or formula (III), R1, Ra and RX are as defined in the specification. The amine complex salts disclosed in the present invention are characterized in a pro-drug active form and various pharmaceutical function.Type: GrantFiled: March 10, 2011Date of Patent: July 30, 2013Assignee: Kaohsiung Medical UniversityInventor: Ing-Jun Chen
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Publication number: 20130030154Abstract: Substrates comprising a solid support, a ligand, and a linker comprising at least one C, O, N, or S atom covalently connecting the solid support to the ligand, are disclosed, along with methods of using and making the substrates, and devices including the substrates.Type: ApplicationFiled: July 23, 2012Publication date: January 31, 2013Applicant: PALL CORPORATIONInventors: Hassan AIT-HADDOU, Frank ONYEMAUWA, Jonathan HAIGH, Samuel NOCHUMSON
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Publication number: 20120321584Abstract: An inhibiting heart failure disease pharmaceutical composition is provided. The pharmaceutical composition includes: an effective amount of a KMUP-3 amine salt of formula (I); wherein RX contains a carboxylic group donated from one selected from a group consisting of a sodium carboxyl methylcellulose (sodium CMC), a ?-polyglutamic acid derivative, and co-polymer salt; RX? is an anion form of the carboxylic group; and a pharmaceutically accepted carrier.Type: ApplicationFiled: January 23, 2012Publication date: December 20, 2012Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventor: Ing-Jun Chen
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Publication number: 20120270237Abstract: The present invention relates to immobilization compounds (I), immobilization products and preparations thereof as well as methods and uses for the identification of kinase interacting compounds or for the purification or identification of kinase proteins.Type: ApplicationFiled: March 31, 2010Publication date: October 25, 2012Applicant: Cellzone AGInventors: Nigel Ramsden, Jeremy Major, John Harrison, Daniel Leggate, Paola Grandi
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Publication number: 20120251482Abstract: The synthesized piperazium salt of KMUPs disclosed in the present invention is characterized by presented pharmaceutics having functions to improve 5-HT function and eNOS expression of KMUPS in lung diseases, such as proliferation, obliteration, pulmonary artery hypertension. The pharmaceutical composition for inhibiting monocrotaline (MCT)-induced proliferation of pulmonary artery includes an effective amount of a complex salt of formula (I): wherein R2 and R4 are each selected independently from the group consisting of a C1˜C5 alkoxy group, a hydrogen, a nitro group, and a halogen atom; RX contains a carboxylic group donated from one selected from a group consisting of a Statin, a Co-polymer, a poly-?-polyglutamic acid (?-PGA) derivative and sodium CMC; and ?RX substituent is an anion of the carboxylic group carrying a negative charge; and a pharmaceutically accepted carrier.Type: ApplicationFiled: September 19, 2011Publication date: October 4, 2012Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventor: Ing-Jun Chen
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Publication number: 20120183984Abstract: The invention provides compounds of formula I F-L-Q (I) where F comprises a fluorophore capable of absorbing energy at an excitation wavelength and, in the absence of a quencher, emitting energy at an emission wavelength, which is different than the excitation wavelength; Q comprises a quencher; L comprises a linker moiety having two ends, one end being covalently bound to F and the other end being covalently bound to Q. The compounds are capable of undergoing a reversible reaction (1), provided below: (1) where Q+ is an oxidized form of Q representing the absence of a quencher, Ox comprises an oxidizing agent, which is capable of oxidizing Q to its oxidized form Q, and Red comprises a reducing agent, which is capable of converting Q back to its reduced form Q. The compounds can undergo photo-induced electron transfer when irradiated with energy and when Q exists in its oxidized form, Q+.Type: ApplicationFiled: July 22, 2010Publication date: July 19, 2012Applicant: OPTI MEDICAL SYSTEMSInventors: Huarui He, Chao Lin
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Publication number: 20120142805Abstract: The invention pertains to an oligomer or polymer substituted by one or more bisacylphosphine oxide moieties, characterized in that said bisacylphosphine oxide moiety is linked via the phosphorous atom, optionally via a spacer group, to the oligomer or polymer backbone; as well as to specifically functionalized bisacylphosphine oxides, suitable to prepare said polymers or oligomers.Type: ApplicationFiled: June 29, 2010Publication date: June 7, 2012Applicant: BASF SEInventors: Hansjorg Grutzmacher, Timo Ott, Kurt Dietliker
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Publication number: 20120122691Abstract: Disclosed are composites that comprise regenerated cellulose, a first active substance, a second active substance, and a linker. Methods for preparing the composites that involve the use of ionic liquids are also disclosed. Articles prepared from the disclosed composites and methods of using them are further disclosed.Type: ApplicationFiled: June 5, 2007Publication date: May 17, 2012Inventors: Daniel T. Daly, Scott K. Spear, Megan B. Turner, Whitney Lauren Hough, Robin D. Rogers
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Publication number: 20120108604Abstract: A series of amine salts including a structure of formula (I) and formula (III) have provided. In formula I or formula (III), R1, Ra and RX are as defined in the specification. The amine complex salts disclosed in the present invention are characterized in a pro-drug active form and various pharmaceutical function.Type: ApplicationFiled: March 10, 2011Publication date: May 3, 2012Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventor: Ing-Jun Chen
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Publication number: 20120083006Abstract: The present invention relates to immobilization compounds (I), immobilization products and preparations thereof as well as methods and uses for the identification of kinase interacting compounds or for the purification or identification of kinase proteins.Type: ApplicationFiled: March 31, 2010Publication date: April 5, 2012Applicant: Cellzone AGInventors: Nigel Ramsden, Jeremy Major, John Harrison, Daniel Leggate, Paola Grandi
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Publication number: 20120058965Abstract: Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro or in vivo from cells of the GI tract of an individual.Type: ApplicationFiled: June 17, 2011Publication date: March 8, 2012Inventors: William A. GODDARD, III, Mark MENNA, Stephen PANDOL, Ravinder ABROL
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Publication number: 20110268896Abstract: A composition comprising an organic fluorophore having a structure of: or a derivative thereof; as well as articles of manufacture marked with the fluorophore, methods for marking articles with the fluorophore, and methods for producing a fluorescent fiber.Type: ApplicationFiled: July 13, 2011Publication date: November 3, 2011Applicant: HONEYWELL INTERNATIONAL INC.Inventors: Thomas Potrawa, Joachim Schulz
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Publication number: 20110252580Abstract: Embodiments herein provide a nanoparticle, such as a metal nanoparticle, coupled to a linker molecule to form a nanoparticle-linker construct. In an embodiment, a nanoparticle-linker construct may be further bound to a substrate to take advantage of one or more properties of the nanoparticle. In an embodiment, a functionalized nanoparticle (a nanoparticle having a reactive functionality) may be bound to a linker to form a functionalized nanoparticle-linker construct which may in-turn be bound to a substrate.Type: ApplicationFiled: November 16, 2009Publication date: October 20, 2011Applicant: Dune Sciences, Inc.Inventors: John M. Miller, James E. Hutchison, Scott F. Sweeney
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Publication number: 20110184164Abstract: A pathogen-resistant fabric comprising one or more photocatalysts capable of generating singlet oxygen from ambient air. The pathogen-resistant fabric may optionally include one or more singlet oxygen traps.Type: ApplicationFiled: March 29, 2011Publication date: July 28, 2011Inventor: John L. Lombardi
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Publication number: 20110173763Abstract: The invention provides a process for aminoarylating cellulosic materials such as cotton and reconstituted fibres and a process for treating the aminoarylated cellulose with an effect chemical such as a dye, flame retardant or cross linking agent. Improved take up of the effect chemical by the modified cellulose means increased efficiency in the process and in the case of dyeing, avoids or reduces the washing off of hydrolysed dye and the resultant production of large volumes of contaminated water requiring to be treated. The cellulosic material may be present in a blend with other types of fibre for example a blend with poly(alkyleneterephthalates) or polyamides.Type: ApplicationFiled: January 26, 2009Publication date: July 21, 2011Inventors: Colin Robert Willis, Stuart Anson Brewer, John Anthony Taylor, Duncan Adrian Phillips
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Patent number: 7943762Abstract: Morpholino oligomers containing both uncharged and cationic intersubunit linkages are provided. The oligomers are oligonucleotide analogs containing predetermined sequences of base-pairing moieties. The presence of the cationic intersubunit linkages in the oligomers, typically at a level of about 10-50% of total linkages, provides enhanced antisense activity, in various antisense applications, relative to the corresponding uncharged oligomers. Also provided are such oligomers conjugated to peptide transporter moieties, where the transporters are preferably composed of arginine subunits, or arginine dimers, alternating with neutral amino acid subunits.Type: GrantFiled: May 10, 2007Date of Patent: May 17, 2011Assignee: AVI BioPharma, Inc.Inventors: Dwight D. Weller, Jed N. Hassinger, Bao Zhong Cai
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Publication number: 20100184965Abstract: The invention relates to a complex consisted of a polysaccharide and an HBP, said polysaccharide being consisted from glycoside bonds of (1,6) and/or (1,4) and/or (1,3) and/or (1,2) type and functionalized with at least one salifiable or salified tryptophan derivative. The invention also relates to a pharmaceutical composition comprising a complex according to the invention and to the use of a polysaccharide consisted of glycoside bonds of (1,6) and/or (1,4) and/or (1,3) and/or (1,2) type and functionalized with at least one salifiable or salified tryptophan derivative, for the preparation of a pharmaceutical formulation of stable HBPs.Type: ApplicationFiled: September 28, 2009Publication date: July 22, 2010Applicant: ADOCIAInventors: Olivier Soula, Remi Soula, Martin Gaudier, Gerard Soula
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Patent number: 7468418Abstract: Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.Type: GrantFiled: April 29, 2004Date of Patent: December 23, 2008Assignee: AVI BioPharma., Inc.Inventors: Patrick L. Iversen, Hong M. Moulton, Michelle H. Nelson, Andrew D. Kroeker, David A. Stein
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Patent number: 7098327Abstract: A process for the production of dual-functional ion exchange resins from lignocellulosic agricultural material involving anionization of the lignocellulosic agricultural material with citric acid and then cationization of the lignocellulosic agricultural material with dimethyloldihydroxyethylene urea (DMDHEU) and choline chloride, or cationization of the lignocellulosic agricultural material with DMDHEU and choline chloride and then anionization of the lignocellulosic agricultural material with citric acid.Type: GrantFiled: August 19, 2004Date of Patent: August 29, 2006Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Wayne E. Marshall, Lynda H. Wartelle
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Patent number: 6828105Abstract: The invention provides antisense antiviral compounds and methods of their use in inhibition of growth of viruses of the picornavirus, calicivirus, togavirus and flavivirus families, as in treatment of a viral infection. The antisense antiviral compounds are substantially uncharged oligomers having a targeting base sequence that is substantially complementary to a viral target sequence which spans the AUG start site of the first open reading frame of the viral genome.Type: GrantFiled: October 16, 2002Date of Patent: December 7, 2004Assignee: AVI BioPharma, Inc.Inventors: David A. Stein, Douglas E. Skilling, Patrick L. Iversen, Alvin W. Smith
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Patent number: 6761272Abstract: Filters and methods for producing filter paper or paper-like nonwoven materially consisting partially or wholly of fibrous cellulose containing material. The filters provided are characterized by high filtration capacity and are capable of absorbing and binding undesirable foreign and attendant substances in the filter medium. The cellulose containing material of the is at least partially carbamided with urea and phosphorylated with phosphoric acid or ammonium phosphate until a nitrogen content in the form of carbamide groups of 1 to 4% and a phosphorous content of 3 to 8% are reached.Type: GrantFiled: November 28, 2001Date of Patent: July 13, 2004Assignee: Helmut KörberInventors: Friedemann Pieschel, Bckehard Lange, Michael Knieling
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Publication number: 20040116332Abstract: This invention provides modified biopolymers comprising biopolymers attached to at least one non-proteinaceous catalyst capable of dismutating superoxide in the biological system or precursor ligand thereof. The invention further provides pharmaceutical compositions comprising the modified biopolymer and therapeutic methods comprising administering the modified biopolymer to a subject in need thereof.Type: ApplicationFiled: November 5, 2003Publication date: June 17, 2004Inventors: Richard L. Ornberg, Kishore Udipi, Denis Forster, Dennis P. Riley, Kenneth B. Thurmond, Susan Henke, Kerry Brethauer, Saikat Joardar
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Patent number: 6635754Abstract: Cellulose particles are described that have cationic groups in their interior. In one aspect, at least 10%, and preferably 50% or more, of the cationic groups are present within the particle interior. Also disclosed are particular combinations of such cellulose particles with certain water-soluble polymers that are well suited for use in the papermaking industry.Type: GrantFiled: December 30, 1999Date of Patent: October 21, 2003Assignee: TFM Handels-AktiengesellschaftInventors: Jörg Oberkofler, Thomas Moser, Anton Schmalhofer, Jeffrey F. Spedding
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Patent number: 6365577Abstract: Antisense oligonucleotides useful for treating a disease state characterized by p53 induction, such as proliferative cell disorders, e.g. cancer, or a hypoxic state induced by an ischemic attack, such as stroke, are described. The antisense agents are preferably of the class known as “steric blocker” type oligonucleotides, including morpholino oligonucleotides, peptide nucleic acids, 2′-O-allyl or 2′-O-alkyl modified oligonucleotides, or N3′→P5′ phosphoramidate oligonucleotides.Type: GrantFiled: October 22, 1999Date of Patent: April 2, 2002Assignee: AVI BioPharma, Inc.Inventor: Patrick L. Iversen
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Patent number: 6365351Abstract: The present invention provides a method for targeting a particular mRNA sequence in vivo by oral administration of a morpholino antisense compound having uncharged phosphorus-containing backbone linkages. Also disclosed is a non-invasive method of detecting and quantitating the in vivo presence of RNA containing one or more selected target sequences. The method includes administering to a subject a nuclease-resistant antisense oligomer which hybridizes by Watson-Crick base pairing to a region of the target RNA with a Tm substantially greater than 37° C. The oligomer is able to complex intracellularly with target RNA, and is released from intracellular sites as a nuclease-resistant heteroduplex, which can then be measured in a body fluid sample, e.g., urine.Type: GrantFiled: January 28, 2000Date of Patent: April 2, 2002Assignee: AVI BioPharma, Inc.Inventor: Patrick L. Iversen
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Patent number: 6197950Abstract: Cationized hydroxyalkylcelluloses, which are highly compatible with surfactants, are represented by the following formula (I): wherein R1, R2 and R3 represent a hydrogen atom or a group represented by the formula CH2CH2OCH2CH (OH) CH2N+(CH3)Cl−, etc.; and “n” is a number of from 50 to 2,000; which have a mobility distribution (&Dgr;U) determined by electrophoresis ranging from 0.1×105 to 2.0×105 cm2/sec·V.Type: GrantFiled: February 8, 1999Date of Patent: March 6, 2001Assignee: Daicel Chemical Industries, Ltd.Inventors: Hiroyuki Nakamura, Shigenobu Sato
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Patent number: 6075166Abstract: The present invention is to novel photochemically cleavable aryl sulfonamides of the formulaP--A.sub.3 --A.sub.2 --A.sub.1 --S(O).sub.2 NR.sub.1 R.sub.2whereinR.sub.1 and R.sub.2 are independently selected from optionally substituted alkyl, arylalkyl or heteroarylalkyl;A.sub.1 is an aryl or heteroaryl moiety;A.sub.2 is a linking agent is an aryl, heteroaryl, arylalkyl, heteroaryl alkyl, or an alkyl, wherein the alkyl moiety in the arylalkyl, heteroaryl alkyl, or alkyl group is optionally interrupted one or more times independently by oxygen, NR.sub.3, sulfur or an amide group;R.sub.3 is alkyl;A.sub.3 is an electron rich aryl or heteroaryl moiety having an E.sub.1/2 potential of 0.5 to 2.0 and which moiety is capable of forming an exciplex;P is a solid support.Another aspect of the present invention is to the novel use of these photolytically cleavable aryl sulfonamides in combinatorial chemistry synthesis, for use in non-sequential encoding, as a tagging agent.Type: GrantFiled: March 31, 1995Date of Patent: June 13, 2000Assignee: SmithKline Beecham CorporationInventors: Ravi Shunker Garigipati, Jerry Leroy Adams
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Patent number: 5684141Abstract: Aminated cellulosic synthetic fibers are produced by adding an amine-substituted cellulose derivative to a viscose or an alkali cellulose and spinning fibers by the viscose spinning process, or by adding said cellulose derivative to a cellulose solution and spinning fibers from said solution.Type: GrantFiled: January 26, 1995Date of Patent: November 4, 1997Assignee: Hoechst AktiengesellschaftInventors: Andreas Schrell, Werner Hubert Russ, Bernd Huber
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Patent number: 5679635Abstract: Canavan disease, an autosomal recessive leukodystrophy, is caused by deficiency of aspartoacylase and accumulation of N-acetylaspartic acid in brain. Human aspartoacylase (ASP) cDNA spanning 1,435 bp has been cloned and expressed in E. coli. A base change, a854>c, has been found in 85% of the 34 Canavan alleles tested so far, which results in a missense glu285>ala mutation that is predicted to be part of the catalytic domain of aspartoacylase. Several additional mutations have also been identified. The invention therefore provides nucleic acid sequences, genes, polypeptides, antibodies, vectors containing the gene, host cells transformed with vectors containing the gene, animal models for the disease, methods for expressing the polypeptide, genetic screening methods and kits, diagnostic methods and kits, methods of treating Canavan disease and methods of genetic therapy for the disease.Type: GrantFiled: September 9, 1994Date of Patent: October 21, 1997Assignee: Miami Children's Hospital Research Institute, Inc.Inventors: Reuben Matalon, Rajinder Kaul, Guang Ping Gao, Kuppareddi Balamurugan, Kimberlee Michals-Matalon
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Patent number: 5614616Abstract: Polysaccharides corresponding to formula (I) ##STR1## in which S is a recurrent monosaccharide unit andB is a group of formula (Ia) attached to the monosaccharide unit S by an O atom ##STR2## are prepared by reaction of polysaccharides with an alkyl halide corresponding to formula (II) ##STR3##Type: GrantFiled: August 16, 1991Date of Patent: March 25, 1997Assignee: Wolff Walsrode AktiengesellschaftInventors: Hans-Josef Buysch, Klaus Szablikowski, J orn Breckwoldt
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Patent number: 5599506Abstract: A gradient mixer for the preparation of immobilized pH-gradient (IPG) gels, which includes a positive displacement syringe dispensing device (4,5) driven by a controlled speed motor (1); a mixer driven by a magnetic stirrer (6); a temperature controlled circulating air oven for the mixer/dispensing syringes (7); a cassette into which mixed solutions of acidic/basic gels are dispensed and the IPG gel is shaped (9); and a second temperature controlled circulating air oven for the cassette (8).Type: GrantFiled: April 5, 1995Date of Patent: February 4, 1997Assignee: Aligena AGInventors: Charles Linder, Mara Nemas, Mordechai Perry, Reuven Ketraro
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Patent number: 5597863Abstract: Immobilized buffered gels obtained from hydroxy group containing natural or synthetic polymers and acid or basic di- or triazine derivatives are useful and highly effective media, e.g. in form of membranes, for preparative isoelectric focusing electrophoresis for separating high molecular compounds, such as proteins or peptides, from biological mixtures.Type: GrantFiled: April 5, 1995Date of Patent: January 28, 1997Assignee: Aligena AGInventors: Charles Linder, Mara Nemas, Mordechai Perry, Reuven Ketraro
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Patent number: 5556773Abstract: A nested polymerase chain reaction (PCR) performed in a single reaction tube that remains closed after the reaction mixtures for each amplification have been introduced therein. The reaction mixture for the second PCR amplification is sequestered and preserved in an upper portion of the single, closed reaction tube during the first amplification, and subsequently introduced into the reaction space containing the end product of the first PCR amplification, without opening the reaction tube.Type: GrantFiled: August 18, 1994Date of Patent: September 17, 1996Inventor: Joseph Yourno
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Patent number: 5451668Abstract: Process for splitting off .DELTA..sup.4 -unsaturated uronic acid from glycosaminoglycan, in which the glycosaminoglycan is treated with an iodine solution or with a bleaching reagent, or with a combination thereof.Type: GrantFiled: January 17, 1990Date of Patent: September 19, 1995Assignee: N.V. AkzoInventors: Constant A. A. Van Boeckel, Gijsbert W. K. Van Dedem
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Patent number: 5430099Abstract: Immobilized buffered gels obtained from hydroxy group containing natural or synthetic polymers and acid or basic di- or triazine derivatives are useful and highly effective media, e.g. in form of membranes, for preparative isoelectric focusing electrophoresis for separating high molecular compounds, such as proteins or peptides, from biological mixtures.Type: GrantFiled: May 27, 1993Date of Patent: July 4, 1995Assignee: Aligena AGInventors: Charles Linder, Mara Nemas, Mordechai Perry, Reuven Ketraro
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Patent number: 5426182Abstract: Polysaccharides, including hydroxyethyl cellulose, having complex hydrophobic group substitution, provide latex compositions, such as paints, with improved rheology and stability. Improved processes for producing such polysaccharides are also provided.Type: GrantFiled: May 29, 1992Date of Patent: June 20, 1995Assignee: Union Carbide Chemical & Plastics Technology CorporationInventors: Richard D. Jenkins, David R. Bassett, Gregory D. Shay
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Patent number: 5378472Abstract: Modified chitins and chitosans with recurring units of the formula ##STR1## wherein R denotes --NH.sub.2, --NHCOCH.sub.3 and R', with R' being present in at least 30% of the recurring units, characterized in that R' represents a group of the formula ##STR2## in a proportion of at least 90%. Due to their favourable biological properties, these materials are advantageously useful in medical and cosmetical applications.Type: GrantFiled: July 27, 1992Date of Patent: January 3, 1995Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventor: Ricardo Muzzarelli
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Patent number: 5187265Abstract: The present invention relates to a chromogenic benzoisothiazolone polymer derivative for measuring the presence or appearance of thiols in an aqueous system.Type: GrantFiled: February 28, 1992Date of Patent: February 16, 1993Assignee: Miles Inc.Inventors: James P. Albarella, David L. Garling, Robert P. Hatch
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Patent number: 5120843Abstract: The aromatic amines (I), alkyl amines (II), bicyclic amines (III). ##STR1## cycloalkyl amines (IV), aromatic bicyclic amines (V), hydroquinone amines (VI), quinone amines (VII), amino-ethers (VIII) and bicyclic amino ethers (IX) are useful as pharmaceutical agents for treating a number of conditions including spinal trauma, mild and/or moderate to severe head injury, etc. Also disclosed is a method of treatment using the 3,4-dihydrobenzopyrans (XI).Type: GrantFiled: October 23, 1989Date of Patent: June 9, 1992Assignee: UpjohnInventors: John M. McCall, Donald E. Ayer, E. Jon Jacobsen, Frederick J. VanDoornik, John R. Palmer
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Patent number: 5026834Abstract: A modified cellulose has a structure represented by the formula ##STR1## Cell is the framework of the unmodified cellulose molecule or of the chitin molecule, in each case without hydroxyl groups. Z is a nitrogen or sulfur atom. In the case where Z is a nitrogen atom, T and Z together are an acylamide or urea group and Q is (X'-Y') and/or together with the O an ester group and/or together with the O a carbamate group. In the case where Z is a sulfur atom, T is omitted and Q together with the O is an ester group and/or together with the O a carbamate group and, as desired, (X'--Y'). The relationships 0<n<m and 0.ltoreq.s<m are obeyed and (n+s) indicates the mean degree of substitution. m=3 in the case of the unmodified cellulose molecule and m=2 in the case of the chitin molecule.Type: GrantFiled: December 9, 1988Date of Patent: June 25, 1991Assignee: Akzo N.V.Inventors: Michael Diamantoglou, Helmut Kuhne
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Patent number: RE38484Abstract: Cationized hydroxyalkylcelluloses, which are highly compatible with surfactants, are represented by the following formula (I): wherein R1, R2 and R3 represent a hydrogen atom or a group represented by the formula CH2CH2OCH2CH (OH) CH2N+(CH3)Cl−, etc.; and “n” is a number of from 50 to 2,000; which have a mobility distribution (&Dgr;U) determined by electrophoresis ranging from 0.1×105 10−5 to 2.0×105 10−5 cm2sec·V.Type: GrantFiled: April 11, 2002Date of Patent: March 30, 2004Assignee: Daicel Chemical Industries, Ltd.Inventors: Hiroyuki Nakamura, Shigenobu Sato