Ethers Patents (Class 536/50)
  • Publication number: 20140073602
    Abstract: The present invention relates to nitric oxide delivering hydroxyalkyl starch derivatives, methods of preparing the same, and specific uses of these hydroxyalkyl starch derivatives.
    Type: Application
    Filed: July 11, 2011
    Publication date: March 13, 2014
    Applicant: FRESENIUS KABI DEUTSCHLAND GMBH
    Inventors: Martin Schimmel, Dominik Heckmann, Cornelius Jungheinrich
  • Publication number: 20140005280
    Abstract: A carboxymethyl starch and chitosan polyelectrolyte complex is provided. A carrier comprising this polyelectrolyte complex along with a solid oral dosage form comprising this polyelectrolyte complex are also provided. A method of manufacturing the polyelectrolyte complex is also provided.
    Type: Application
    Filed: January 19, 2012
    Publication date: January 2, 2014
    Applicant: 4413261 Canada Inc. (Spencer Canada)
    Inventors: Elias Assaad, Mircea-Alexandru Mateescu
  • Publication number: 20130184237
    Abstract: The present invention relates to nitric oxide delivering hydroxyalkyl starch derivatives, methods of preparing the same, and specific uses of these hydroxyalkyl starch derivatives.
    Type: Application
    Filed: July 11, 2011
    Publication date: July 18, 2013
    Applicant: FRESENIUS KABI DEUTSCHLAND GMBH
    Inventors: Martin Schimmel, Dominik Heckmann, Cornelius Jungheinrich
  • Publication number: 20120046240
    Abstract: The present invention relates to methods of producing hydroxyalkyl starch (HAS) derivatives having a structure according to formula (I) comprising reacting HAS of formula (I) at its optionally oxidized reducing end or a HAS derivative, obtainable by reacting HAS of formula (I) at its optionally oxidized reducing end with a compound (D) comprising at least one functional group Z1 capable of being reacted with the optionally oxidized reducing end of the HAS and at least one functional group W, with a compound (L) comprising at least one functional group Z1 capable of being reacted with said HAS, or at least one functional group Z2 capable of being reacted with functional group W comprised in said HAS derivative, and at least one functional group X capable of being reacted with a functional group Y of a further compound. The present invention further relates to HAS derivatives and pharmaceutical compositions comprising them.
    Type: Application
    Filed: June 28, 2010
    Publication date: February 23, 2012
    Inventors: Norbert Zander, Harald Conradt, Wolfram Eichner
  • Publication number: 20120046235
    Abstract: Conjugates of an active substance and hydroxyalkyl starch (HAS) are provided herein. The active substance and the HAS are linked by a chemical moiety having a structure according to formula (I) wherein Y is O or S, and X is SH or (F). The conjugate has a structure according to formula (IV) wherein HAS? is a residue of HAS or a derivative thereof linked to the thioester group, and AS? is a residue of the active substance or derivative thereof linked to the alpha-X beta-amino group; or a structure according to formula (V) wherein HAS? is a residue of HAS or derivative thereof linked to the alpha-X beta-amino group, and AS? is a residue of the active substance or derivative thereof linked to the thioester group, and wherein the group —(C?Y) is derived from the thioester group —(C?Y)—S—R? and the group HN—CH—CH2—X is derived from the alpha-X beta amino group.
    Type: Application
    Filed: September 8, 2006
    Publication date: February 23, 2012
    Inventors: Nobert Zander, Ronald Frank
  • Publication number: 20100317609
    Abstract: The present invention relates to methods of producing hydroxyalkyl starch (HAS) derivatives having a structure according to formula (I) comprising reacting HAS of formula (I) at its optionally oxidized reducing end or a HAS derivative, obtainable by reacting HAS of formula (I) at its optionally oxidized reducing end with a compound (D) comprising at least one functional group Z1 capable of being reacted with the optionally oxidized reducing end of the HAS and at least one functional group W, with a compound (L) comprising at least one functional group Z1 capable of being reacted with said HAS, or at least one functional group Z2 capable of being reacted with functional group W comprised in said HAS derivative, and at least one functional group X capable of being reacted with a functional group Y of a further compound. The present invention further relates to HAS derivatives and pharmaceutical compositions comprising them.
    Type: Application
    Filed: June 28, 2010
    Publication date: December 16, 2010
    Inventors: Norbert Zander, Harald Conradt, Wolfram Eichner
  • Publication number: 20100311670
    Abstract: Conjugates of an active substance and hydroxyalkyl starch (HAS) are provided herein. The active substance and the HAS are linked by a chemical moiety having a structure according to formula (I) wherein Y is O or S, and X is SH or (F). The conjugate has a structure according to formula (IV) wherein HAS? is a residue of HAS or a derivative thereof linked to the thioester group, and AS? is a residue of the active substance or derivative thereof linked to the alpha-X beta-amino group; or a structure according to formula (V) wherein HAS? is a residue of HAS or derivative thereof linked to the alpha-X beta-amino group, and AS? is a residue of the active substance or derivative thereof linked to the thioester group, and wherein the group —(C?Y) is derived from the thioester group —(C?Y)—S—R? and the group HN—CH—CH2—X is derived from the alpha-X beta amino group.
    Type: Application
    Filed: September 8, 2006
    Publication date: December 9, 2010
    Inventors: Nobert Zander, Ronald Frank
  • Patent number: 7595007
    Abstract: Water-soluble amino acid copolymers, modified polysaccharides, acrylamide polymers, and combinations thereof, are described, for uses including flocculation of solids, particularly flocculation of soil, such as in an agricultural setting. Also described are methods of preparing selected amino acid copolymers and modified polysaccharides.
    Type: Grant
    Filed: June 22, 2006
    Date of Patent: September 29, 2009
    Assignees: Aquero Company, ValuGen LLC
    Inventors: C. Steven Sikes, Mark A. Hochwalt, T. Daniel Sikes
  • Publication number: 20080281000
    Abstract: Novel cross-linked gels comprised of alkoxyetheramides grafted to polysaccharides that have superior viscosity properties have been made. By controlling the chain length of the alkoxyetheramides and the hydrophobic nature of the gel, these materials are ideal for many uses such as in hydraulic fracturing of oil-bearing geological formations, in the paint and dye industries, as dispersants, in personal care products and for carriers in controlled drug delivery.
    Type: Application
    Filed: September 6, 2006
    Publication date: November 13, 2008
    Inventors: William H. Daly, Ahmad A. Bahamdan
  • Publication number: 20080076914
    Abstract: The invention provides a method for the synthesis of an 18F-labelled product comprising deprotected of a protected 18F-labelled compound using a deprotection agent comprising a weak acid and wherein neutralisation and buffering of the deprotected product are carried out by the addition of a neutralisation agent. The deprotected product is buffered in a pH range suitable for subsequent autoclaving and formulation into an injectable radiopharmaceutical.
    Type: Application
    Filed: September 23, 2005
    Publication date: March 27, 2008
    Inventors: Julian Grigg, Nigel Osborn
  • Patent number: 7022836
    Abstract: The invention relates to a method for producing protoplasts of cassava or closely related species, which protoplasts are capable of regeneration into plants. The method comprises producing friable embryogenic callus from explants of cassava or closely related species and isolating protoplasts from said friable embryogenic callus. The invention also concerns protoplasts obtainable by said method. The invention further relates to a method for transforming such a protoplast of cassava or closely related species, and transformed protoplasts obtainable thereby. In addition, the invention concerns a method for regenerating plants from these protoplasts and a cassava plant or closely related species obtainable thereby. Starch isolated from tubers of such cassava plants have an increased amylopectin content. The starch and a method for isolating it from said plants also forms part of the invention.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: April 4, 2006
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Richard G. F. Visser, Christiaan J. J. Raemakers, Evert Jacobson, Johanna Elizabeth M. Bergorvoet van Deelen
  • Patent number: 6958314
    Abstract: A petro-chemical free nonionic surfactant is prepared by the alkylation of an alkyl polyglucoside (APG). Under suitable alkylation reaction conditions, the surfactants are preferably prepared by the reaction of an APG with either alkyl halide or an alkyl tosylate. These surfactants are low foaming and exhibit excellent detergency.
    Type: Grant
    Filed: March 5, 2003
    Date of Patent: October 25, 2005
    Assignee: Master Chemical Corporation
    Inventor: David B. McCall
  • Patent number: 6897028
    Abstract: Identification of the molecular targets of a drug or toxin is the first step in understanding how the drug or toxin works, an important advance in learning how to improve a drug or assess the risks due to a toxin. The primary action of a drug usually involves binding to a protein; secondary actions may express themselves in the form of side effects and in some cases may be due to binding to other proteins. Consequently, it is useful to identify all physiologically relevant sites of action of a drug or toxin. A simple method for obtaining a list of the potential targets of a drug, toxin or other biologically active substance (referred to collectively as ligands) involves a multistep process. The first step is screening a protein or peptide library to identify library members that exhibit high affinity for a particular ligand. The second step involves searching of sequence data bases for proteins that contain the sequences of the library members shown to have high affinity for the ligand.
    Type: Grant
    Filed: July 7, 1998
    Date of Patent: May 24, 2005
    Assignee: Florida State University
    Inventors: Lee Makowski, Diane R. Makowski, Hitesh J. Sanganee
  • Patent number: 6872820
    Abstract: Finely divided polysacharide derivatives are described. The finely divided polysacharide derivatives are prepared by a process comprising: a) forming an aqueous composition comprising a polysaccharide derivative and water, in which the polysaccharide derivative is soaked or dissolved; b) converting the polysaccharide derivative of the aqueous composition into finely divided solid particles by, (i) contacting the aqueous composition with superheated water vapor in a dryer-pulverizer; or (ii) causing the polysaccharide derivative of the aqueous composition to flocculate; and c) optionally drying the finely divided solid particles of step b). The primary structures of the polysaccharide starting material are largely removed, and the product has a shape factor of less than 5 and greater than or equal to 1.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: March 29, 2005
    Assignee: Wolff Walsrode AG
    Inventors: Gunter Weber, Detmar Redeker, Bernd Klinksiek, Jürgen Hinderer, Benno Ulfik
  • Patent number: 6600033
    Abstract: The invention relates to a cellulose ether that is hydrophobically modified with an alkyl or alkenylketene dimer of general formula (I), in which R1 and R2 are alkyl or alkenyl chain, such as one having 5 to 22, preferably 13 to 20, most preferably 14 to 18 carbons. The product can be used in water-based products to control the rheological properties, for example. Objects of use include, for example, detergents, paper coating mixtures, paints, dispersing agents, and oil drilling muds.
    Type: Grant
    Filed: June 19, 2000
    Date of Patent: July 29, 2003
    Assignee: Metsa Specialty Chemicals Oy
    Inventors: Mikko Lähteenmäki, Heidi Känköhen, Göran Kloow, Oliver Ruppert, Jennifer Ann Leupin, Eugene Paul Gosselink
  • Patent number: 6528629
    Abstract: Disclosed is a method for preparing a malto-oligosaccharide derived glycoside. Generally, the method comprises providing a malto-oligosaccharide and glycosylating the malto-oligosaccharide with an alcohol or a thiol under conditions suitable to form a malto-oligosaccharide derived glycoside. Also disclosed is a method for preparing a mixture of malto-oligosaccharide derived glycosides by providing a mixture of malto-oligosaccharides and glycosylating the malto-oligosaccharides with an alcohol or a thiol under substantially anhydrous conditions to form a mixture of malto-oligosaccharide derived glycosides.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: March 4, 2003
    Assignee: Grain Processing Corporation
    Inventors: Richard G. Rogers, Frank W. Barresi
  • Publication number: 20020128468
    Abstract: This invention relates to new cyclodextrin derivatives, processes for producing these cyclodextrin derivatives, and inclusion complexes comprised of the new cyclodextrin derivatives and guest molecules, as well as methods of making such materials and related materials and methods of using the same.
    Type: Application
    Filed: January 11, 2002
    Publication date: September 12, 2002
    Inventors: Charles M. Buchanan, Steven N. Falling, Juanelle L. Lambert, Shannon E. Large, Jozsef Szejtli, Lajos Szente, Laszlo Jicsinszky
  • Patent number: 6441057
    Abstract: The present invention discloses novel polymer compositions comprising cellulose acrylamide, acrylamide and/or a fluorescent indicator species, and membranes made with these compositions. Optical pH sensors for monitoring the pH in a fluid sample, and methods for making such pH sensors are also disclosed. The pH sensors have reduced sensitivity to sample components that can interfere with pH measurements.
    Type: Grant
    Filed: March 30, 2000
    Date of Patent: August 27, 2002
    Assignee: Optical Sensors Incorporated
    Inventors: Lynn M. Kimball, Laura J. Bauer, William V. Fowler, Laurie E. Lynch
  • Publication number: 20020026992
    Abstract: A graft polymer comprises a carbohydrate polymer having pendant 3-amino-2-hydroxy propyl groups grafted thereon and may be employed as a retention aid and strengthening additive in paper manufacture. When the carbohydrate polymer is a component of wood pulp the resulting chemically modified wood pulp may be employed in conjunction with unmodified wood pulp to incorporate therein the retention and strengthening characteristics.
    Type: Application
    Filed: July 2, 2001
    Publication date: March 7, 2002
    Inventors: Miroslav Antal, Makhlouf Laleg, Ivan Ignac Pikulik
  • Publication number: 20010025102
    Abstract: Stable, cold water soluble, ready for use starch aldehyde compositions and the method of preparation of such compositions wherein an aqueous dispersion of a fluidity or converted starch acetal is hydrolyzed under acidic conditions to form the starch aldehyde which is then spray dried into a cold water soluble starch aldehyde powder.
    Type: Application
    Filed: May 9, 2001
    Publication date: September 27, 2001
    Inventors: A. Levent Cimecioglu, Bjork Ohlhorst, Daniel B. Solarek, Douglas J. Slete, James L. Eden
  • Patent number: 6265570
    Abstract: Stable, cold water soluble, ready for use starch aldehyde compositions and the method of preparation of such compositions wherein an aqueous dispersion of a converted starch acetal is hydrolyzed under acidic conditions to form the starch aldehyde which is then spray dried into a cold water soluble starch aldehyde powder.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: July 24, 2001
    Assignee: National Starch & Chemical Investment Holding Corporation
    Inventors: A. Levent Cimecioglu, Bjork Ohlhorst, Daniel B. Solarek, Douglas J. Slate, James L. Eden
  • Patent number: 6123738
    Abstract: 2,3-Epoxypropyltrimethylammonium chloride having reduced color and method of preparation are disclosed. 2,3-Epoxypropyltrimethylammonium chloride is treated with sodium hypochlorite to reduce its color. 2,3-Epoxypropyltrimethylammonium chloride can be prepared via reaction of trimethylamine and epichlorohydrin. If desired, an aprotic solvent can be used. 2,3-Epoxypropyltrimethylammonium chloride formed in the resultant slurry, must then be isolated via known methods, such as evaporation, extraction, centrifugation, etc, depending upon the other constituents of the slurry and the residual epichlorohydrin removed. The final product is then treated with an effective amount of sodium hypochlorite. The obtained 2,3-epoxypropyltrimethylammonium chloride then is used for, for example, color-sensitive applications such as to produce cationic starch for use in paper manufacture.
    Type: Grant
    Filed: August 19, 1998
    Date of Patent: September 26, 2000
    Assignee: The Dow Chemical Company
    Inventors: Laren P. Childers, Dorothy L. Roerden
  • Patent number: 6121439
    Abstract: A coating composition is composed of a water-soluble polysaccharide composition comprising at least one hydrophobic group selected from aryl, alkyl, alkenyl, aralkyl and mixtures thereof and at least one quaternary ammonium salt group, both connected to a polysaccharide backbone by covalent bonds. This coating is used for improving the leveling of waterborne paints.
    Type: Grant
    Filed: July 27, 1998
    Date of Patent: September 19, 2000
    Assignee: Hercules Incorporated
    Inventor: Gijsbert Kroon
  • Patent number: 5883242
    Abstract: The present invention provides a cationic starch prepared by roasting starch under the presence of a cationic polymer, a method for preparing the cationic starch, and a method for making paper board with the cationic starch. The method for making paper board of the present invention provides high retention of starch in paper board, enhances paper board strength in a high level and reduces a load of treating waste water from a paper machine, in comparison with the starch which has conventionally been employed for paper making.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: March 16, 1999
    Assignee: Sanwa Cornstarch Co., Ltd.
    Inventors: Satoshi Kubota, Akitomo Terada, Yoshiteru Yamamoto
  • Patent number: 5833755
    Abstract: A process for the degradation of starch, particularly granular starch, using hydrogen peroxide and a catalytic amount of a metal-based coordination complex in an alkaline slurry reaction.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: November 10, 1998
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Peter J. Schlom, Rose Ann Schultz
  • Patent number: 5739304
    Abstract: Water-soluble polysaccharides which containa) substituents selected from the group consisting of alkyl, hydroxyalkyl, carboxyalkyl and sulfoalkyl,b) N,N-disubstituted aminoalkyl groups,are prepared by alkylation of a polysaccharide in the presence of a base with one or more alkylation reagents, selected from the group consisting of compounds transferring alkyl groups, compounds transferring hydroxyalkyl groups, compounds transferring carboxyalkyl groups and compounds transferring sulfoalkyl groups, and also with an N,N-disubstituted amino-alkylsulfuric acid ester. The modified polysaccharides are used in paper production and waste-water purification and also in cosmetics.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: April 14, 1998
    Assignee: Hoechst AG
    Inventors: Reinhard Doenges, Rudolf Ehrler, Andreas Schrell
  • Patent number: 5708162
    Abstract: Process for the preparation of low molecular weight polysaccharide ethers which can be employed in binders for improving adhesive power and film-forming properties, by oxidative degradation of relatively high molecular weight polysaccharide ethers, which comprises initially introducing a relatively high molecular weight polysaccharide ether in suspension (e.g. in a slurry), adding a perborate or a mixture of perborate and perborate activator, and carrying out the oxidative degradation at a temperature of between 25.degree. and 90.degree. C.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: January 13, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Josef Hilbig, Reinhard Doenges
  • Patent number: 5652360
    Abstract: Disclosed herein is a new cationic starch and cationic starch paste or slurry. The starch paste or slurry has a low cation equivalent value despite its high nitrogen content and also has a low solution viscosity despite its high molecular weight. The cationic starch and cationic starch paste or slurry is formed by substitution with a one or both of quaternary ammonium salt or a tertiary amino group, characterized in that its nitrogen content (X) due to the quaternary ammonium salt and/or tertiary amino group is related to its cation equivalent value (Y) as defined below:Y<0.70097X-0.07978(in the case of natural terrestrial stem starch)Y<0.32936X-0.00495(in the case of natural subterranean stem starch having ester-type substituents)Y<0.40942X+0.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 29, 1997
    Assignee: Japan Corn Starch Co., Ltd
    Inventors: Hideyuki Tanaka, Hiroshige Murase, Takahiro Kuno, Kyoko Kitamura
  • Patent number: 5574149
    Abstract: A method for treating HIV infections comprising administering a composition whose active ingredient is 2',3'-dideoxy-3'-fluoro-5'-chlorouridine.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: November 12, 1996
    Assignee: Glaxo Wellcome Inc.
    Inventors: Joel Van Tuttle, Susan M. Daluge, Charlene L. Burns, George W. Koszalka, Thomas A. Krenitsky
  • Patent number: 5473059
    Abstract: Water soluble quaternary ammonium ethers of polysaccharides or polyols wherein the quaternary ammonium ether substituents correspond to the formula ##STR1## wherein R.sub.1 is a monohydroxylated or polyhydroxylated alkyl group containing between about one and about six carbon atoms; R.sub.2 and R.sub.3 are independently, alkyl groups containing between about one and about six carbon atoms; R.sub.4 is an alkyl group containing between about six and about 24 carbon atoms; and X is a halide, wherein the degree of substitution of said ethers ranges from about 0.001 to about 0.5. is provided. The composition have multiple uses as thickeners and are particularly suited for use in personal care products.
    Type: Grant
    Filed: October 13, 1994
    Date of Patent: December 5, 1995
    Assignee: Rhone-Poulenc Inc.
    Inventor: Michael H. Yeh
  • Patent number: 5455340
    Abstract: Amino-multicarboxylate starch ether derivatives are provided having the following structure: ##STR1## wherein St-O represents a starch molecule,R is H or CH.sub.3 ;R' is H, CH.sub.3 or COOH;M is a cation;n is 2 or 3; andR" is H or alkyl of 1 to 18 carbon atoms.These starch derivatives are particularly useful as retention and strength aids in papermaking.
    Type: Grant
    Filed: February 2, 1994
    Date of Patent: October 3, 1995
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Karen A. Bernard, John Tsai, Robert L. Billmers, Robert W. Sweger
  • Patent number: 5387675
    Abstract: Water soluble quaternary ammonium ethers of polysaccharides or polyols wherein the quaternary ammonium ether substituents correspond to the formula ##STR1## wherein R.sub.1 is a monohydroxylated or polyhydroxylated alkyl group containing between about one and about six carbon atoms; R.sub.2 and R.sub.3 are independently, alkyl groups containing between about one and about six carbon atoms; R.sub.4 is an alkyl group containing between about six and about 24 carbon atoms; and X is a halide, wherein the degree of substitution of said ethers ranges from about 0.001 to about 0.5. is provided. The composition have multiple uses as thickeners and are particularly suited for use in personal care products.
    Type: Grant
    Filed: March 10, 1993
    Date of Patent: February 7, 1995
    Assignee: Rhone-Poulenc Specialty Chemicals Co.
    Inventor: Michael H. Yeh
  • Patent number: 5349089
    Abstract: Cationic polysaccharide derivatives are prepared by reacting a polysaccharide with a polycationic reagent having one polysaccharide reactive group and at least two cationic groups. Suitable reagents include polycationic alkyl, aryl, alkaryl, cycloaliphatic, or heterocyclic amines, some of which are novel compositions. The polycationic polysaccharide derivatives prepared from these reagents are useful in the manufacture of paper.
    Type: Grant
    Filed: January 11, 1993
    Date of Patent: September 20, 1994
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Peter T. Trzasko, Michael T. Philbin
  • Patent number: 5278303
    Abstract: This invention relates to the preparation of oligosaccharides, using polymer supported methodology. By this method, which offers anomeric control, oligosaccharides are produced very rapidly in comparison with known methodologies. Thus, there is disclosed a process for the preparation of oligosaccharides which comprisesa) forming a synthon of a saccharide and a monomethylether of polyethylene glycol or a derivative thereof, the synthon having a linkage between the oligosaccharide and the monomethylether of polyethylene glycol or a derivative thereof, which linkage can be severed under conditions that do not damage glycosidic or other bonds in a desired end product;b) subjecting the synthon to repeated additions of a suitable glycosylating agent to form a desired oligosaccharide-polyethylene glycol linked product;c) isolating the linked product as a solid;d) purifying this solid; ande) releasing the oligosaccharide from the polyethylene glycol.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: January 11, 1994
    Assignee: University of Toronto Innovations Foundation
    Inventors: Jiri J. Krepinsky, Stephen P. Douglas, Dennis M. Whitfield
  • Patent number: 5241061
    Abstract: A process for dry cationization of starch or a starch-containing material comprises reacting the starch or starch-containing material with a dialkyl(epoxyalkyl)amine or trialkyl(epoxyalkyl) ammonium halide in a medium containing a maximum of 40% by weight of water in the presence of an alkali metal or alkaline earth metal oxide or hydroxide and a finely-divided aluminosilicate clay, having a cation-exchange capacity less than about 15 meq/100 g.
    Type: Grant
    Filed: May 27, 1992
    Date of Patent: August 31, 1993
    Assignee: The Dow Chemical Company
    Inventors: Dorothy L. Roerden, Clara D. Wessels
  • Patent number: 5239118
    Abstract: The synthesis of stable, ten-membered, cyclic conjugated enediynes is described. Said compounds were successfully employed to cleave double-stranded DNA spontaneously at ambient temperatures.
    Type: Grant
    Filed: December 9, 1991
    Date of Patent: August 24, 1993
    Assignee: Trustees of the University of Penna.
    Inventors: Kyriacos C. Nicolaou, Guido Zuccharello, Yuji Ogawa
  • Patent number: 5227481
    Abstract: Cationic polysaccharide derivatives are prepared by reacting a polysaccharide with a polycationic reagent having one polysaccharide reactive group and at least two cationic groups. Suitable reagents include polycationic alkyl, aryl, alkaryl, cycloaliphatic, or heterocyclic amines, some of which are novel compositions. The polycationic polysaccharide derivatives prepared from these reagents are useful in the manufacture of paper.
    Type: Grant
    Filed: April 9, 1991
    Date of Patent: July 13, 1993
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: John J. Tsai, Peter T. Trzasko, Michael T. Philbin, Robert L. Billmers, Martin M. Tessler, Joseph A. Van Gompel, Morton W. Rutenberg
  • Patent number: 5192666
    Abstract: .alpha.-Amylase activity can be determined rapidly and precisely by using as a substrate a modified oligosaccharide wherein a benzyloxymethyl group or a halomethyl group is bonded to the C.sub.6 position of non-reducing-end glucose residue and the reducing-end glucose residue is bonded to a group which exhibits an optically measurable change upon cleavage. Processes for producing such a compound are also disclosed.
    Type: Grant
    Filed: December 29, 1989
    Date of Patent: March 9, 1993
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Tokuji Ikenaka, Kaoru Omichi, Shinji Satomura, Yuko Nagamine
  • Patent number: 5171849
    Abstract: There is disclosed a process for preparing carboranyl uridine nucleoside compounds and their diethyl ether adducts, which exhibit a tenfold increase in boron content over prior art boron containing nucleoside compounds. Said carboranyl uridine nucleoside compounds exhibit enhanced lipophilicity and hydrophilic properties adequate to enable solvation in aqueous media for subsequent incorporation of said compounds in methods for boron neutron capture therapy in mammalian tumor cells.
    Type: Grant
    Filed: April 19, 1991
    Date of Patent: December 15, 1992
    Assignee: The Ohio State University Research Foundation
    Inventors: Albert H. Soloway, Rolf F. Barth, Abul K. Anisuzzaman, Fazlul Alam, Werner Tjarks
  • Patent number: 5116966
    Abstract: The present invention relates to a process for purifications of natural or synthetic polymers in solution, water-soluble or soluble in water-alcohol medium and comprising sulfate groups, the process consisting essentially, on the one hand, of a selective precipitation in which the sulfated polymers to be purified are complexed in acid medium with a polyamine insoluble at a pH greater than 7 and, on the other hand, after isolation of the complex thus formed, of a progressive solubilizing of the sulfated polymers.
    Type: Grant
    Filed: January 3, 1990
    Date of Patent: May 26, 1992
    Assignee: Societe de Developpement des Utilisations du Cuir - SADUC
    Inventors: Christian Gagnieu, Michel DuBois
  • Patent number: 5116967
    Abstract: The invention relates to a method of preparing an adjustable-viscosity cationized starch in which, in a process step in the presence of 10 to 35 wt. % water and preferably 0.01 to 2.00 wt. % of a finely-divided silica and/or silicate (in each case relative to the total amount of mixture) the starch is homogenized with an alkaline oxide, hydroxide, silicate aluminate or mixtures thereof, an alkylene epoxide and a peroxo compound or a mixture of at least two peroxo compounds and then boiled in known manner at the desired time.
    Type: Grant
    Filed: May 17, 1990
    Date of Patent: May 26, 1992
    Assignee: Degussa Aktiengesellschaft
    Inventors: Wolfgang Fischer, Dietmar Bischoff, Michael Huss, Reinhard Stober, Gert Roessler
  • Patent number: 5066793
    Abstract: Finely particulate cellulose esters of aromatic or aromatic-aliphatic carboxylic acids in the form of substantially spherical, partially crystalline particles having an average diameter of 1 to 200 .mu.m and a specific surface area of 10 to 300 m.sup.2 /g, are suitable for use as stationary phase in methods of chromatographic separation, especially for the resolution of racemates.
    Type: Grant
    Filed: October 13, 1988
    Date of Patent: November 19, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Eric Francotte, Gabriele Baisch
  • Patent number: 5051500
    Abstract: A method of preparing a bulking agent useful in the replacement of carbohydrates and/or fats is provided. The bulking agent is comprised of a randomly-bonded polysacchardie prepared from a granular reducing saccharide and a granular edible polyol by means of an apparatus having a vented chamber with means for conveying the ingredients longitudinally through said chamber with lateral mixing of said ingredients and minimal longitudinal mixing of said ingredients.
    Type: Grant
    Filed: August 11, 1989
    Date of Patent: September 24, 1991
    Assignee: A. E. Staley Manufacturing Company
    Inventor: Roy O. Elmore
  • Patent number: 5011918
    Abstract: A polysaccharide derivative having the structure Sacch--O--Z--Ar--CH.dbd.N--Y or ##STR1## where Sacch--O-- represents a polysaccharide molecule; Z is --(CH.sub.2).sub.n -- or ##STR2## Ar is a divalent aromatic group; Y is (a) a monovalent group derived from a water-soluble substituted or unsubstituted aromatic compound containing only one free primary amine group, or (b) a monovalent group derived from a water-soluble substituted or unsubstituted aliphatic or cycloaliphatic compound containing only one primary amine group, or (c) a multivalent group derived from a water-soluble protein containing more than one primary amine group; n is one or greater; and m is zero or greater, is prepared by first modifying the polysaccharide with a reagent to introduce free aromatic aldehyde groups and then reacting with a suitable amine-containing reagent. The siloxane-containing starch derivaties are useful in glass forming size compositions.
    Type: Grant
    Filed: January 25, 1990
    Date of Patent: April 30, 1991
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Robert L. Bilimers, David M. Del Giudice, Martin M. Tessler
  • Patent number: 4985410
    Abstract: Quaternary ammonium salts of polysaccharides possessing hypochlolesterolemic activity and having the following general formula: ##STR1## in which A represents the monomer unit of a natural polysaccharide, m is a whole number between 100 and 1000, n is a whole number between 0 and 4, B is O or S or NH or NR, R is a linear alkyl radical of 1-4 carbon atoms, and X.sup.(-) is an anion such as Cl.sup.-, Br.sup.-, I.sup.-, HSO.sub.4.sup.-, CH.sub.3 O--SO.sub.3.sup.-.Said salts are prepared by reacting a pretreated natural polysaccharide with a a quaternary ammonium salt functionalized at one of its ends with an epoxy group.
    Type: Grant
    Filed: May 2, 1988
    Date of Patent: January 15, 1991
    Assignee: Etablissement Texcontor
    Inventor: Franco Conti
  • Patent number: 4973641
    Abstract: A polysaccharide graft copolymer containing a reactive aminoethyl halide group is provided, said copolymer represented by:Sacch--g--(M).sub.a --(T).sub.bwhere Sacch is a polysaccharide base substrate, M is a repeating unit of the formula: ##STR1## where X is halogen and R is hydrogen or alkyl of 1 to 2 carbons; T is an ethylenically unsaturated comonomer, a is at least 1 and b is 0 or 1 or more, with the total of a and b being at least 2.Another embodiment provides preparing this graft copolymer by reacting the monomer in a system that is maintained at a pH level of below 7 to prevent premature reaction of the halogen on the aminoethyl halide group during the grafting procedure.
    Type: Grant
    Filed: November 18, 1988
    Date of Patent: November 27, 1990
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: John J. Tsai, Eric A. Meier
  • Patent number: 4966607
    Abstract: A method of producing a dyed polysaccharide which comprises linking a dye, capable of linking to amino group or imino group, to a starch derivative having a glucose derivative unit shown in a general formula [I] as a partial structure of the starch derivative. ##STR1## In the formula [I], R represents an arylene group or an alkylene group, R.sub.1, represents hydrogen atom or an alkyl group, and X and Y represent linking portions to other portions of the starch molecule, respectively.According to the method of the invention, dyed polysaccharides can readily be obtained by using a commercial reactive dye at room temperature under neutral conditions.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: October 30, 1990
    Assignee: Fuji Photo Film Co. Ltd.
    Inventors: Hiroshi Shinoki, Mitsunori Ono
  • Patent number: 4952279
    Abstract: Disclosed are a papermaking method comprising the steps of sheet-formation of an aqueous papermaking stock which contains a cellulose fiber or the said fiber and an inorganic filler, dewatering and drying, charaacterized by the addition of a starch ether derivative of a general formula (I): ##STR1## where St--O represents a starch molecule residue, R.sub.1, R.sub.2 and R.sub.3 independently represent an alkyl group having from 1 to 18 carbon atoms or a benzyl group, provided that two or more of these R.sub.1, R.sub.2 and R.sub.3 must not be a benzyl group or an alkyl group having from 5 to 18 carbon atoms at the same time, and any two of these R.sub.1, R.sub.2 and R.sub.3 may be bonded to form a cyclic structure, the said derivative containing the ether bond preferably in a degree of substitution of from 0.01 from 0.1, to the said papermaking stock in an amount of from 0.05 to 5.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: August 28, 1990
    Assignee: Nissan Chemical Industries Ltd.
    Inventors: Hisao Ikeda, Fumio Suzuki, Yoshitane Watanbe, Mitsunobu Matsumura, Yasuhiro Takahashi, Hiroshi Murakami, Koichi Maeda
  • Patent number: 4876336
    Abstract: Improved amphoteric starch derivatives containing tertiary amino or quaternary ammonium groups and anionic phosphate groups are disclosed. The derivatives which are defined by a minimum bound phosphorus content, a minimum viscosity and other criteria have use as wet-end additives and provide improved drainage properties in the manufacture of paper.
    Type: Grant
    Filed: May 18, 1987
    Date of Patent: October 24, 1989
    Assignee: National Starch and Chemical Corporation
    Inventors: Daniel B. Solarek, Teresa A. Dirscherl, Henry R. Hernandez, Wadym Jarowenko
  • Patent number: 4788280
    Abstract: Polysaccharide aldehydes having the formula ##STR1## or Sacch--O--CH.sub.2 --Ar--CHO (II) such as starch, cellulose, and gum aldehydes, are useful as paper additives for imparting strength and as the granular or gelatinized portion of a corrugating adhesive. Those having formula I are prepared by a nonoxidative method which involves reacting the polysaccharide base, in the presence of alkali, with a derivatizing acetal reagent having the general structure ##STR2## and then hydrolyzing the acetal by adjusting the pH to less than 7, preferably 2-4. In the formula Ar is an aryl group, optionally containing an ether linkage, or an alkaryl group and A and A' are lower alkyls or together form at least a 5-membered cyclic acetal. The polysaccharide aldehydes are crosslinked by the addition of selected polyfunctional crosslinkers such as an aliphatic primary polyamine or polyketone.
    Type: Grant
    Filed: September 8, 1987
    Date of Patent: November 29, 1988
    Assignee: National Starch and Chemical Corporation
    Inventors: Robert L. Billmers, Martin M. Tessler, David M. Del Giudice, Craig Leake