Subsequent Treatment Process Patents (Class 536/61)
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Patent number: 10676861Abstract: A method for incorporating ultraviolet radiation protection and antimicrobial protection into rayon has the steps of providing pulp to form cellulose sheets, steeping the cellulose sheets, pressing the cellulose sheets, shredding the cellulose sheets into white crumb, aging the white crumb to form yellow crumb, xanthation of the yellow crumb, dissolving the yellow crumb to form a viscose, adding an additive to the viscose, ripening the viscose, filtering the viscose, degassing the viscose, spinning the viscose to form a filament of rayon, drawing the rayon, washing the rayon, and cutting the rayon.Type: GrantFiled: November 8, 2019Date of Patent: June 9, 2020Assignee: THE SWEET LIVING GROUP, LLCInventors: Robert B. Kramer, Ronald Kramer, Nicholas Marshall, Peter Hauser, Jason Rosenberg
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Patent number: 10472762Abstract: A method for incorporating ultraviolet radiation protection and antimicrobial protection into rayon is disclosed which has the steps of providing pulp to form cellulose sheets, steeping the cellulose sheets, pressing the cellulose sheets, shredding the cellulose sheets into white crumb, aging the white crumb to form yellow crumb, xanthation of the yellow crumb, dissolving the yellow crumb to form a viscose, adding an additive to the viscose, ripening the viscose, filtering the viscose, degassing the viscose, spinning the viscose to form a fine filament of rayon, drawing the rayon, washing the rayon, and cutting the rayon.Type: GrantFiled: February 5, 2019Date of Patent: November 12, 2019Assignee: THE SWEET LIVING GROUP, LLCInventors: Robert B Kramer, Ronald Kramer, Nicholas Marshall, Peter Hauser, Jason Rosenberg
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Patent number: 9050619Abstract: Coating systems and processes are disclosed for uniformly coating objects. The system comprises a pre-treatment unit, a first processing unit, a first post-treatment unit and one or more coating apparatus each configured to engage an object and rotate the object around or about two or more axes. The coating apparatus used in the system can comprise a first, second and/or third gimbals connected to rotational mechanisms to allow rotation of the gimbals around or about first, second and/or third axis. An object holder is connected to the third gimbal. When an object is present in the object holder, it can be immersed in a coating solution to form a coated object. The coated object is then rotated around or about two or three axes which produces a multidirectional centrifugal force which causes the coating solution to spread evenly over the surface of the object to produce a uniform thin film.Type: GrantFiled: August 7, 2012Date of Patent: June 9, 2015Assignee: Advenira Enterprises, Inc.Inventor: Elmira Ryabova
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Patent number: 8664152Abstract: The present invention provides a porous cellulose gel having a high mechanical strength capable of being operated at a higher flow rate, and a method for producing the same. To a suspension liquid of cellulose particles, a crosslinking agent in an amount of from 4 to 12 times the amount of the cellulose monomer in terms of moles and an alkali in an amount of from 0.1 to 1.5 times the amount of the crosslinking agent in terms of moles are added continuously dropwise or added dividedly over a prescribed period of time, whereby flow rate characteristics of a resulting porous cellulose gel can be enhanced. According to the invention, the production efficiency of a polymer substance, such as a nucleic acid and a protein can be enhanced.Type: GrantFiled: August 27, 2008Date of Patent: March 4, 2014Assignee: JNC CorporationInventors: Yasuto Umeda, Yasuo Matsumoto, Masami Shiina, Masami Todokoro, Yoshihiro Matsumoto
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Publication number: 20130110684Abstract: A forensic marker is disclosed including a marker that is added to the host material and is detectable for at least the expected life of the host material. The marker is inert with respect to the host material in that it does not significantly affect the desired qualities of the host material (e.g. weight, adhesive properties, structural integrity, etc). The marker is detectable, for example, by instruments, during the life of the host material.Type: ApplicationFiled: October 27, 2011Publication date: May 2, 2013Inventor: Jorge G. Chiappo
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Publication number: 20130079508Abstract: The invention relates to a filter having a layer which is permeable to a medium to be filtered, comprising at least one nonwoven part, wherein the nonwoven part withstands higher mechanical loads. According to the invention the layer comprises, in addition to the nonwoven part, at least one sheet-like support part connected to at least one sub-region of at least one side of the nonwoven part.Type: ApplicationFiled: September 26, 2012Publication date: March 28, 2013Inventors: Enrico Mahlig, Dirk Stocker, Bernd Lubitz
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Patent number: 7837916Abstract: A method for manufacturing silicate-containing fiber, wherein silicon dioxide is added to viscose manufactured of cellulose, and the formed mixture of viscose and silicon dioxide is directed via nozzles to a regeneration solution, to which silicate is added.Type: GrantFiled: June 1, 2005Date of Patent: November 23, 2010Assignee: Sateri International Co. Ltd.Inventors: Aarto Paren, Timo Partanen, Asko Peltonen
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Patent number: 7462306Abstract: A cellulose acylate film that has: an in-plane retardation Re and a retardation Rth in a thickness direction at a wavelength of 590 nm, which are satisfied with ranges of expressions (I) to (III); a coefficient of a thermal expansion of from 20 ppm/° C. to 100 ppm/° C.; and a haze of from 0.01 to 0.8, and a polarizing plate and a display device using the same. 20?Re?50??Expression (I) 70?Rth?200??Expression (II) 1.0?Rth/Re?3.0??Expression (III) In the foregoing expressions, each of Re and Rth is a value at 25° C. and 60% RH, and has a unit of nm.Type: GrantFiled: November 2, 2005Date of Patent: December 9, 2008Assignee: Fujifilm CorporationInventor: Nobutaka Fukagawa
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Patent number: 7148344Abstract: Using the dope containing the following cellulose acetate (1), (2), or (3), a film is prepared by the casting process: (1) a cellulose acetate having carboxyl groups binding to at least one member selected from the group consisting of a cellulose acetate and a hemicellulose acetate, wherein at least a part of said carboxyl groups are in an acidic form; (2) a cellulose acetate containing at least one member selected from the group consisting of an acid having an acid dissociation exponent pKa of 1.93 to 4.50 in water, an alkali metal salt of said acid and an alkaline earth metal of said acid; or (3) a cellulose acetate containing an alkali metal or an alkaline earth metal wherein the total content of an alkaline metal and an alkaline earth metal in 1 gram of the cellulose acetate is from an effective amount to 5.5×10?6 equivalent (in terms of ion equivalent). The above cellulose acetate is also useful for spinning process. The cellulose acetate includes a cellulose diacetate and a cellulose triacetate.Type: GrantFiled: April 29, 2005Date of Patent: December 12, 2006Assignee: Daicel Chemical Industries, Ltd.Inventors: Yukiko Nakanishi, Hiroki Taniguchi, Katako Ueda
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Patent number: 6538130Abstract: In the manufacture of viscose, and an elongate cellulose member such as standard viscose rayon fibre, with reduced alkali ratio from dissolving-grade cellulose such as wood pulp by irradiation with a high energy beam at a dose of 1-30 kGy, steeping in aqueous sodium hydroxide, pressing to form alkali cellulose, xanthating to form cellulose xanthate, dissolving in aqueous liquor to form viscose and (when elongate cellulose members are required) extruding through a die into an acid bath for coagulation and regeneration to form an elongate cellulose member which is then washed and dried, viscose filtration can be improved by including in the dissolving liquor for the cellulose xanthate an amount of from 200 to 10000 ppm by weight of a salt which consists of alkali metal or ammonium cations and anions of a strong acid.Type: GrantFiled: March 21, 2000Date of Patent: March 25, 2003Assignee: Acordis Kelheim GmbHInventors: Klaus Fischer, Heinzhorst Möbius, Tatjana Poggi
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Patent number: 6515121Abstract: Cellulosic fibrids can be made by mixing together under turbulent conditions viscose and a coagulating and regenerating liquor containing preformed fibrids to form a suspension of fibrids in a spent liquor, and collecting the fibrids from the spent liquor.Type: GrantFiled: September 11, 2000Date of Patent: February 4, 2003Assignee: Acordis Kelheim GmbHInventors: Andrzej Marek Mackiewicz, Guy Edward Scudder, Sabine Seddon
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Patent number: 6124442Abstract: The process includes obtaining a liquid extract from a fresh plant source material and mixing the extract with a solution saturated with at least one element having an oxidation number of one or two or combinations thereof. The resulting mixture provides for a solid precipitate material and a liquid portion containing the triterpene glycosides of which is then passed through a macroporous resin. The resin is then washed with an alcohol to obtain a solution thereof containing the triterpene glycosides. The solution is condensed to provide a purified liquid triterpene glycoside solution and then a drying step is performed to obtain a dry composition containing the triterpene glycosides.Type: GrantFiled: March 24, 1999Date of Patent: September 26, 2000Inventors: James H. Zhou, Weiping He
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Patent number: 6045587Abstract: A method of reducing color and polymerization decay of cellulose viscose includes the step of permeating a 1,3-phenylene-bis 2-oxazoline as a polymerization anti-decay additive during dissolving a cellulose in water and a solvent to form a cellulose viscose, so as to reduce the color and the polymerization decay of the cellulose viscose.Type: GrantFiled: May 9, 1998Date of Patent: April 4, 2000Assignee: Acelon Chemical and Fiber CorporationInventors: Meng-Song Cheng, Kun Shan Huang, J. H. Tsai
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Patent number: 6017906Abstract: The present invention relates to methods of preventing or treating an infection or disease caused by an infectious agent. The present invention also relates to the augmentation of the efficacy of existing anti-infective agents by the co-administration of the compounds described herein.Type: GrantFiled: May 5, 1998Date of Patent: January 25, 2000Assignee: Intercardia, Inc.Inventors: Clifford S. Mintz, Natan A. Kogan, Ramesh Kakarla, Helena R. Axelrod, Michael J. Sofia
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Patent number: 5908833Abstract: Novel compounds which are a glucocorticosteroid (GCS) chemically bound to a sugar, having the general formulaGCS.sup.1 --O--Sugar.sup.1for colon- or ileum-specific delivery of the GCS to inflamed bowel mucosa, as well as processes for their preparation, pharmaceutical preparations containing the compounds and the use of said compounds in therapy.Type: GrantFiled: December 13, 1996Date of Patent: June 1, 1999Assignee: Aktiebolaget AstraInventors: Ralph Lennart Brattsand, Peter Edman, Thomas Hogberg, Stinabritt Nilsson, Bror Arne Thalen, Jan Erik Ulmius
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Patent number: 5760009Abstract: A crystalline monohydrate of (3.beta.,5.alpha.,25R)-3-?(.beta.-D-cellobiosyl)oxy!spirostan-11-one that is useful as a hypocholesterolemic or antiatherosclerosis agent.Type: GrantFiled: October 19, 1995Date of Patent: June 2, 1998Assignee: Pfizer Inc.Inventors: Douglas J. M. Allen, Harry A. Watson, Jr., Jonathan B. Zung
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Patent number: 5744453Abstract: The present invention relates to methods of preventing or treating an infection or disease caused by an infectious agent. The present invention also relates to the augmentation of the efficacy of existing anti-infective agents by the co-administration of the compounds described herein.Type: GrantFiled: January 5, 1996Date of Patent: April 28, 1998Inventors: Clifford S. Mintz, Natan A. Kogan, Ramesh Kakarla, Helena R. Axelrod, Michael J. Sofia
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Patent number: 5695738Abstract: Compositions of sterodial glycosides are described wherein the glycoside is linked directly, or indirectly to a desired steroidal compound via a carbon, or similar stable linkage, and methods of using the compositions to treat patients by binding to and/or blocking cellular receptors for a variety of diseases including cancer, inflammation, and autoimmune diseases.Type: GrantFiled: June 15, 1995Date of Patent: December 9, 1997Assignee: Glycomed IncorporatedInventors: Mark Anderson, John Henry Musser
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Patent number: 5684141Abstract: Aminated cellulosic synthetic fibers are produced by adding an amine-substituted cellulose derivative to a viscose or an alkali cellulose and spinning fibers by the viscose spinning process, or by adding said cellulose derivative to a cellulose solution and spinning fibers from said solution.Type: GrantFiled: January 26, 1995Date of Patent: November 4, 1997Assignee: Hoechst AktiengesellschaftInventors: Andreas Schrell, Werner Hubert Russ, Bernd Huber
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Patent number: 5606041Abstract: Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypo-cholesterolemic agent tigogenin beta-cellobioside. The process comprises reacting .alpha.-cellobiosyl bromide heptaalkanoate and .beta.-tigogenin in the presence of zinc fluoride or zinc cyanide under conditions capable of forming said tigogenyl .beta.-O-cellobioside heptaalkanoate. The analogous preparations of hecogenin .beta.-O-cellobioside heptaalkanoate 11-ketotigogenin .beta.-O-cellobioside heptaalkanoate, and diosgenin .beta.-O-cellobioside heptaalkanoate are also disclosed. The process provides both high .beta.-anomeric selectivity and high yields.Type: GrantFiled: December 20, 1994Date of Patent: February 25, 1997Assignee: Pfizer Inc.Inventors: Frank R. Busch, Kathleen D. Goggin, John F. Lambert, Russell J. Shine, Stanley W. Walinsky
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Patent number: 5591836Abstract: Disclosed are novel saponins containing 5-C-hydroxymethylhexose and a sterol or triterpene. These materials, when consumed by humans and animals, lower the cholesterol level in the blood. These compounds can be administered as pharmaceutical preparation to the diet, or incorporated into food compositions.Type: GrantFiled: October 7, 1993Date of Patent: January 7, 1997Assignee: The Procter & Gamble CompanyInventors: Adam W. Mazur, Stanislaw Pikul, Bruce P. Daggy
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Patent number: 5583112Abstract: Saponin/antigen conjugates and the use thereof for enhancing immune responses in individuals are disclosed. The saponins may be substantially pure or mixtures of saponins.Type: GrantFiled: July 2, 1992Date of Patent: December 10, 1996Assignee: Cambridge Biotech CorporationInventors: Charlotte A. Kensil, Sean Soltysik, Dante J. Marciani
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Patent number: 5563250Abstract: The present invention provides cleavable conjugates whose linkers contain a labile bond that is cleavable under a variety of mild conditions, including weakly acidic. Since the agent may be bonded directly to the linker, cleavage can result in release of native agent. The invention also provides methods for producing cleavable conjugates. Preferred agents include drugs, toxins, biological response modifiers, radiodiagnostic compounds, radiotherapeutic compounds, and derivatives thereof. The targeting molecule employed in the invention may be an intact molecule, a fragment thereof, or a functional equivalent thereof. In a particularly preferred embodiment, the targeting molecule is a monoclonal antibody directed towards a tumor-associated antigen in man. The invention further provides methods for delivering to the cytoplasm of a target cell an agent free of its targeting molecule carrier.Type: GrantFiled: May 13, 1994Date of Patent: October 8, 1996Assignee: NeoRx CorporationInventors: Mark D. Hylarides, Ananthachari Srinivasan, Jeffrey N. Fitzner, Vivekananda M. Vrudhula
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Patent number: 5530107Abstract: Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypocholesterolemic agent tigogenin beta-cellobioside. The process comprises reacting .alpha.-cellobiosyl bromide heptaalkanoate and .beta.-tigogenin in the presence of zinc fluoride or zinc cyanide under conditions capable of forming said tigogenyl .beta.-O-cellobioside heptaalkanoate. The analogous preparations of hecogenin .beta.-O-cellobioside heptaalkanoate, 11-ketotigogenin .beta.-O-cellobioside heptaalkanoate, and diosgenin .beta.-O-cellobioside heptaalkanoate are also disclosed. The process provides both high .beta.-anomeric selectivity and high yields.Type: GrantFiled: May 23, 1994Date of Patent: June 25, 1996Assignee: Pfizer Inc.Inventors: Douglas J. M. Allan, Frank R. Busch, John F. Lambert, Russell J. Shine, Stanley W. Walinsky
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Patent number: 5525480Abstract: The present invention provides N- and O-substituted aminophenol derivatives of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, G and L are as hereinbefore defined. The present invention also provides intermediates for the preparation of these aminophenol derivatives of general formula (I), as well as the use of the aminophenol derivatives of general formula (I) for the determination of hydrolases, as well as for the preparation of agents for carrying out determinations of hydrolysis.Type: GrantFiled: June 9, 1994Date of Patent: June 11, 1996Assignee: Boehringer Mannheim GmbHInventors: Gerd Zimmermann, Dieter Mangold
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Patent number: 5438125Abstract: Sialic acid compounds of formula ##STR1## wherein X is hydrogen, a lower alkyl group or benzyl, Y is hydrogen or acetyl, Ac is acetyl, and the wavy line represents that the compound of the formula (I) includes both a .alpha.-anomer and .beta.-anomer, have excellent chemical and enzymatical stability and are useful in the treatment of central or peripheral nervous diseases.Type: GrantFiled: March 4, 1992Date of Patent: August 1, 1995Assignee: Nippon Zoki Pharmaceutical Co., Ltd.Inventors: Kaoru Okamoto, Shinji Morita
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Patent number: 5426179Abstract: Steroid compounds active on the cardiovascular system of formula ##STR1## wherein X, n, R, R.sub.1 and R.sub.2 have the meanings mentioned in the description are described.Type: GrantFiled: February 12, 1992Date of Patent: June 20, 1995Assignee: Zambon Group S.p.A.Inventors: Giorgio Bertolini, Cesare Casagrande, Stefania Montanari, Gabriele Norcini, Francesco Santangelo
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Patent number: 5324823Abstract: The invention provides a selective adsorbent for cellular fibronectin (cFN) and a method for fractional purification of FN which includes contacting an FN material containing plasma fibronectin (pFN) and cFN with a crosslinked polysaccharide sulfate and/or an immobilized polysaccharide sulfate to fractionate the pFN and cFN.By the fractional purification method of the invention, cFN and pFN can be fractionated in an expedient manner and with high efficiency and both pFN and cFN can be recovered in high purity and good yield.Type: GrantFiled: November 19, 1992Date of Patent: June 28, 1994Assignee: Otsuka Pharmaceutical Factory, Inc.Inventors: Kaneji Asakawa, Ryoichi Umemoto, Kazuo Hino, Eiji Sakashita, Takashi Komai
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Patent number: 5294703Abstract: Provided is a novel improved process for the preparation of .alpha.-D-cellobiose octaacetate via the acetylative degradation of cellulose or cellulose acetate. The title compound is provided in high yield and quality in a facile one-pot process, amenable to large-scale synthesis.Type: GrantFiled: April 7, 1993Date of Patent: March 15, 1994Assignee: Eastman Kodak CompanyInventors: John A. Hyatt, Tony L. Sander, D. Mark Naylor, Bobby L. Bernard
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Patent number: 5198537Abstract: The present invention provides digoxigenin derivatives of the formula: ##STR1## wherein n is a whole number of from 1 to 4 and Z is a carboxyl group or a functional derivative derived therefrom. The present invention also provides digoxigenin conjugates of the general formula: ##STR2## wherein the carrier is an immunogenic carrier material, a nucleic acid or a labelled immunocomponent of a labelled digoxigenin immunoconjugate for use in an immunoassay, m is a number from 1 to the number of coupling positions available on the carrier and Y is the group formed by the reaction of the carboxyl function Z of the digoxigenin derivative of general formula (I) with the reacting position of the carrier material. Also described are uses of these conjugates as nucleic acid probes, immunogens, and in immunoassay.Type: GrantFiled: October 25, 1989Date of Patent: March 30, 1993Assignee: Boehringer Mannheim GmbHInventors: Erasmus Huber, Klaus Muhlegger, Herbert von der Eltz, Bruno Zink
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Patent number: 5124441Abstract: Therapeutically active organic compound exhibiting at least one group comprising a structure --S'--S"--R, wherein the group --S"--R is defined by R being an organic group comprised in a physiologically acceptable compound H--S"--R obtainable by the splitting of the disulfide bridge --S'--S"-- in said structure, in which compound H--S"--R the sulfur atom S" is bound to a carbon atom in a heterocyclic aromatic ring in R having a configuration being such that the compound H--S"--R, while maintaining physiological acceptability, is stabilized, by tautomerism or resonance involving the sulfur atom S" bound to R, so as to be mainly excluded from reaction involving thiol disulfide exchange; S' being bound to an aliphatic carbon atom; and said compound, in addition to the group or groups comprising the structure --S'--S"--R, consisting of a residue of a therapeutically active organic base compound of non-polypeptide structure bound to S'.Type: GrantFiled: April 29, 1985Date of Patent: June 23, 1992Assignee: Pharmacia AktiebolagInventors: Jan P. E. Carlsson, Rolf E. A. V. Axen
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Patent number: 5108596Abstract: This invention relates to ion-exchanged fine cellulose particles, porous fine cellulose particles which can be advantageously used as an affinity carrier, and methods of production thereof. These fine particles of the invention have the advantage that they possess excellent pressure-resistant strength and can treat treatment liquors under pressure at a high flowing velocity. Thus, they can be advantageously used industrially in various separation and purification processes.Type: GrantFiled: December 4, 1989Date of Patent: April 28, 1992Assignee: Kanebo Ltd.Inventors: Shigeru Ookuma, Kouei Igarashi, Masami Hara, Kazuhiro Aso, Hideo Yoshidome, Hiroshi Nakayama, Keizo Suzuki, Kazuhiko Nakajima
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Patent number: 5106963Abstract: Phospholipid conjugate compounds derived from cardiac glycosides and sters useful in liposome immunoassays are disclosed as well as their method of preparation.Type: GrantFiled: June 28, 1991Date of Patent: April 21, 1992Assignee: Miles, Inc., successor in interest to Technicon Instruments Corp.Inventors: Deng R. Hwang, Mary E. Scott, Eddie Hedaya
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Patent number: 5091520Abstract: Finely particulate cellulose esters of aromatic or aromatic-aliphatic carboxylic acids in the form of substantially spherical, partially crystalline particles having an average diameter of 1 to 200 .mu.m and a specific surface area of 10 to 300 m.sup.2 /g, are suitable for use as stationary phase in methods of chromatographic separation, especially for the resolution of racemates.Type: GrantFiled: September 5, 1990Date of Patent: February 25, 1992Assignee: Ciba-Geigy CorporationInventors: Eric Francotte, Gabriele Baisch
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Patent number: 5053497Abstract: Phospholipid conjugate compounds derived from cardiac glycosides and steroids useful in liposome immunoassays are disclosed as well as their method of preparation.Type: GrantFiled: July 21, 1988Date of Patent: October 1, 1991Assignee: Technion Instruments CorporationInventors: Deng R. Hwang, Mary E. Scott, Eddie Hedaya
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Patent number: 5010185Abstract: Improved processes for the synthesis of tigogenin beta-cellobioside, a known hypocholesterolemic agent, using cellobiose heptaacetate and tigogenin as starting materials.Type: GrantFiled: June 13, 1989Date of Patent: April 23, 1991Assignee: Pfizer Inc.Inventor: Frank J. Urban
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Patent number: 5003054Abstract: A method for performing a diagnostic immunoassay by solid phase separation for digoxin. To a reaction mixture of a test sample and labeled anti-digoxin antibody, which forms a complex of any digoxin present in the test sample, is added a solid phase material having an immobilized ouabain triacetate derivative compound capable of binding any excess labeled antibody. The solid phase material is chosen to rapidly settle whereby a solid and liquid phase is formed. The liquid phase can then be extracted to measure the amount of digoxin-labeled antibody present therein. Ouabain triacetate derivative compounds possess sufficient affinity for anti-digoxin antibodies, and are therefore useful in a solid phase separation based digoxin immunoassay for settling out such antibodies without contributing to undesired background interference.Type: GrantFiled: August 23, 1988Date of Patent: March 26, 1991Assignee: Abbott LaboratoriesInventors: Frank C. Grenier, Terry A. Pry, Lawrence Kolaczkowski
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Patent number: 4997935Abstract: A modified cellulose for biocompatible dialysis membranes having a structure represented by the formula ##STR1## wherein cell is cellulose or chitin, in each case without hydroxyl groups, s=3 in the case of cellulose and s=2 in the case of chitin, R' is CH.sub.3 and/or C.sub.2 H.sub.5 and/or C.sub.3 H.sub.7, X denotes specified functional groups, R" is H or R, R"' denotes R, x+t=0.75 to 2.85, t=0 to 2.85, x=0 to 2.85, and r=0 to 1. A process for preparation of the cellulose derivatives is also disclosed.Type: GrantFiled: February 27, 1989Date of Patent: March 5, 1991Assignee: Akzo N.V.Inventor: Michael Diamantoglou
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Patent number: 4981960Abstract: A modified cellulose for biocompatible dialysis membranes having a structure represented by the formula ##STR1## wherein Cell is cellulose or chitin, in each case without hydroxyl groups, s=3 in the case of cellulose and s=2 in the case of chitin, R' is CH.sub.3 and/or C.sub.2 H.sub.5 and/or C.sub.3 H.sub.7, X denotes specified functional groups, R" is H or R, Z corresponds to the following groups of atoms: SR", SO.sub.3 H and salts thereof, SO-R, SONR".sub.2, SO.sub.2 -R, SO.sub.2 NR".sub.2, SO.sub.2 H and salts thereof, F, Cl, Br, I, NR".sub.2, PR".sub.2, PO.sub.3 H.sub.2 and salts thereof, PO.sub.2 H(OR), PO(OR).sub.2, PO.sub.2 HR" and salts thereof, POR"(OR) and POR".sub.2, x+t=0.75 to 2.85, t=0 to 2.85, x=0 to 2.85, and z=0.01 to 0.45. A process for preparation of the cellulose derivatives is also disclosed.Type: GrantFiled: February 27, 1989Date of Patent: January 1, 1991Assignee: Akzo N.V.Inventor: Michael Diamantoglou
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Patent number: 4981959Abstract: A modified cellulose for biocompatible dialysis membranes having a structure represented by the formula ##STR1## wherein cell is unmodified cellulose or chitin, in each case without hydroxyl groups, s=3 in the case of cellulose and s=2 in the case of chitin, R' is CH.sub.3 and/or C.sub.2 H.sub.5 and/or C.sub.3 H.sub.7, X denotes specified functional groups, m=0.75 to 2.85, and x=0.005 to 2.10. A process for preparation of the cellulose derivatives is also disclosed.Type: GrantFiled: February 27, 1989Date of Patent: January 1, 1991Assignee: Akzo N.V.Inventor: Michael Diamantoglou
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Patent number: 4946953Abstract: Fine crosslinked cellulose particles, wherein (1) said cellulose particles are composed substantially of a II-type cellulose crystalline phase and a non-crystalline cellulose phase, (2) said cellulose particles have a crystallinity, determined by X-ray diffractometry, of 5 to 35%, (3) said cellulose particles consist substantially of spherical to elongated spherical particles having an average particle diameter of not more than 300 .mu.m, and (4) said cellulose particles having an exclusion limit molecular weight by polyethylene glycol of not more than 4,000. The particles may have crosslinkage among the cellulose molecular chains in the non-crystalline phase.Type: GrantFiled: October 13, 1987Date of Patent: August 7, 1990Assignees: Kanebo, Ltd., Kanebo Rayon, Ltd.Inventors: Shigeru Okuma, Kanji Yamagishi, Masami Hara, Keizo Suzuki, Toshihiro Yamamoto, Hideo Yoshidome
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Patent number: 4918180Abstract: A process for reducing the dust content of cellulose ethers comprises reacting the cellulose ether with an aggregating agent comprising (1) a polypropylene glycol or a propoxylated alcohol and (2) an ethylene oxide/propylene oxide copolymer.Type: GrantFiled: November 23, 1988Date of Patent: April 17, 1990Assignee: Union Carbide Chemicals and Plastics Company, Inc.Inventor: Serge Huybrechts
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Patent number: 4902792Abstract: A process for producing fine cellulose particles, which comprises(1) mixing viscose with a water-soluble anionic polymeric compound or polyethylene glycol or its derivative to form a dispersion of fine particles of viscose,(2) (i) heating the dispersion or mixing it with a coagulating agent to thereby coagulate the viscose in the dispersion, and thereafter neutralizing it with an acid to form fine particles of cellulose, or (ii) coagulating and neutralizing the dispersion with an acid to form fine particles of cellulose, and(3) thereafter, separating the fine particles of cellulose from the motor liquor. The fine cellulose particles(a) are composed substantially of II-type cellulose,(b) have a crystallinity, of 5 to 35% by weight,(c) are composed substantially of particles of not more than 20 micrometers, and(d) have a sharp particle size distribution.Type: GrantFiled: December 30, 1987Date of Patent: February 20, 1990Assignees: Kanebo Ltd., Kanebo Rayon, Ltd.Inventors: Shigeru Okuma, Kanji Yamagishi, Masami Hara, Keizo Suzuki, Toshihiro Yamamoto
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Patent number: 4882315Type: GrantFiled: October 29, 1987Date of Patent: November 21, 1989Assignee: Farmitalia Carlo Erba S.p.A.Inventors: Laura Chiodini, Mauro Gobbini, Sergio Mantegani, Daniel Ruggieri, Aldemio Temperilli, Gabriella Traquandi, Patrizia Ferrari
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Patent number: 4814437Abstract: A new method for preparation of sulfated polysaccharides by means of pyridine-chlorosulfonic acid reagents. The polysaccharide is before sulfation treated with a reducing agent, e.g. sodium borohydride.Type: GrantFiled: February 25, 1988Date of Patent: March 21, 1989Assignee: Pharmacia ABInventors: Anthony N. de Belder, Leif G. Ahrgren, Tomas Malson
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Patent number: 4780314Abstract: This invention relates to a novel recovery process for obtaining the small molecular weight, digitalis-like factor, and further relates to purification of the digitalis-like factor. This invention also relates to the identification and characterization of the factor and to therapeutic uses for the purified factor.Type: GrantFiled: October 30, 1985Date of Patent: October 25, 1988Assignee: Brigham and Women's HospitalInventor: Steven W. Graves
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Patent number: 4603196Abstract: The invention relates to a process for the preparation of .beta.-methyldigoxin by the selective methylation of digoxin with dimethyl sulfate in the presence of a basic strontium compound and, if appropriate, of an inert inorganic adsorbent. Strontium hydroxide octahydrate, strontium methylate or strontium hydroxymethylate is used as the basic strontium compound, and an oxide, silicate or phosphate of magnesium, calcium, aluminum, silicon or titanium, with a water content in the range of 0 to 20% by weight, is used as the inorganic adsorbent. The reaction is carried out at temperatures of -15.degree. to 15.degree. C. in the presence of 3 to 24 moles of water per mole of digoxin, the water being introduced in the reaction mixture by the water content of strontium hydroxide octahydrate and/or the inorganic adsorbent used and purification of the methylation product so formed by column chromatography on SiO.sub.2 with a mixture of chlorohydrocarbon and a lower aliphatic alcohol.Type: GrantFiled: May 21, 1984Date of Patent: July 29, 1986Assignee: Chemie Linz AktiengesellschaftInventor: Rudolf Franzmair
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Patent number: 4562250Abstract: Methods for the production of steroids (sapogenins) and steroidal glycosides (saponins) from cell, root-cell and shoot tissue cultures of the Yucca plant. The cultures were established and maintained in a suitable nutrient plant cell medium supplemented with growth regulators. The desired products are extracted from the cultures using conventional extraction techniques. Greater total production of steroidal glycosides occurred in root-cell, cell, and shoot tissue cultures in that order. Although the cultures may be grown under conditions ranging from total darkness to total light, steroidal glycoside production was highest in root-cell cultures grown continuously in the light as compared to those grown in the dark. Root-cell culture senescence also enhanced the yield of total steroidal glycosides. Steroids are obtained from the steroidal glycosides by acid hydrolysis to remove the sugar moieties. The production of radio-labeled steroids and steroidal glycosides is disclosed.Type: GrantFiled: September 13, 1982Date of Patent: December 31, 1985Assignee: Regents of the University of MinnesotaInventors: E. John Staba, Jean J. MacCarthy
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Patent number: 4546097Abstract: Digitonin and digitonin-related saponins are derivatized by alkoxylation. The adducts have lower toxicity, higher solubility, and reduced ability to form insoluble complexes with cholesterol, as compared to the starting material. The adducts are particularly useful as solubilizing agents for lipophilic drugs and as mycoplasma suppressors in cell cultures.Type: GrantFiled: November 4, 1983Date of Patent: October 8, 1985Assignee: The United States of America as represented by the Department of Health and Human ServicesInventor: Josef Pitha
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Patent number: 4482706Abstract: Novel steroid saponin compounds (XR-1) and (XR-2) are extracted from Solanam aculeatissimum, a plant belonging to the Solanum genus, and 16-dehydropregnenolone is obtained by hydrolyzing the said compounds, subjecting the hydrolyzed product to Marker's degradation, and treating the obtained product with aqueous alkali.Type: GrantFiled: April 20, 1983Date of Patent: November 13, 1984Assignee: Tokiwa Yakuhin Kogyo Kabushiki KaishaInventors: Toshiaki Tomimatsu, Kotaro Murakami