Heavy Metal Or Aluminum Containing Patents (Class 540/465)
  • Patent number: 10100014
    Abstract: Metallotriangle-based nanomolecules are formed by a one-step self-assembly of specifically chosen shaped poly-ligand monomers, the poly-ligand monomers coordinating with metal ions through coordinating ligands. The poly-ligand monomers are defined by vertex groups having arms extending therefrom and ending in coordinating ligands. Based on the desired metallotriangle-based nanomolecule structure to be assembled, specifically shaped poly-ligand monomers and metal ions are chosen and mixed in appropriate ratios so that coordinating ligands bind to metal ions and the poly-ligand monomers thus spontaneously self-assemble into the desired metallotriangle-based nanomolecule structure.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: October 16, 2018
    Assignee: The University of Akron
    Inventors: George R. Newkome, Charles N. Moorefield
  • Patent number: 9944668
    Abstract: Manganese coordination complexes with utility as magnetic resonance probes and as biological reductant sensors are disclosed. In one embodiment, ligands can stabilize both the Mn2+ and Mn3+ oxidation states. In the presence of a reductant such as glutathione, low relaxivity MnIII-HBET is rapidly converted to high relaxivity MnII-HBET with a 3-fold increase in relaxivity, and concomitant increase in magnetic resonance signal. In another embodiment, ligands were designed to chelate Mn(ll) in a thermodynamically stable and kinetically inert fashion while allowing for direct interaction of Mn(ll) with water. In yet another embodiment, high molecular weight multimers containing six Mn(ll) chelators were prepared. The high molecular weight results in slower tumbling of the molecules in solution and can strongly enhance the Mn(ll) relaxivity.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: April 17, 2018
    Assignee: The General Hospital Corporation
    Inventors: Peter Caravan, Eric M. Gale, Galen S. Loving, Shereya Mukherjee, Jiang Zhu
  • Patent number: 9907868
    Abstract: A process for the preparation of complexes containing 68Ga wherein a buffer formic acid/formate in the presence of compounds capable to sequester metal cations is used in the complexation reaction.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: March 6, 2018
    Assignee: Advanced Accelerator Applications International S.A.
    Inventors: Lorenza Fugazza, Maria Azzurra Filannino, Maurizio Franco Mariani
  • Patent number: 9375498
    Abstract: A process for the preparation of complexes containing 68Ga wherein a buffer formic acid/formate in the presence of compounds capable to sequester metal cations is used in the complexion reaction.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: June 28, 2016
    Assignee: Advanced Accelerator Applications S.A.
    Inventors: Lorenza Fugazza, Maria Azzurra Filannino, Maurizio Franco Mariani
  • Patent number: 9117771
    Abstract: The invention relates to the fields of microelectronics and materials sciences and concerns an insulation layer material for integrated circuits in microelectronics, which can be used, for example, in integrated circuits as insulation material in semiconductor components. The object of the present invention is to disclose an insulation material for integrated circuits, which has dielectric constants of k?2 with good mechanical properties at the same time. The object is attained with an insulation material for integrated circuits, containing at least MOFs and/or COFs.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: August 25, 2015
    Assignees: LEIBNIZ-INSTITUT FUER FESTKOERPER-UND WERKSTOFFFORSCHUNG DRESDEN E.V., GLOBALFOUNDRIES INC.
    Inventors: Gotthart Seifert, Helmut Hermann, Konstyantyn Zagorodniy, Ehrenfried Zschech
  • Patent number: 9040689
    Abstract: The invention relates to the use of compounds comprising at least one 2-(1H-tetrazol-5-yl)pyridine unit, of formula (I) below: as ligands for lanthanides and, more especially, as organic chromophores for complexing these elements. It also relates to lanthanide complexes using these compounds as complexing organic chromophores, and to new compounds containing one or more 2-(1H-tetrazol-5-yl)pyridine units, which are useful as ligands for lanthanides and, in particular, as organic chromophores for complexing these elements. Applications: photonics and optoelectronics, especially for forming light-emitting devices such as electroluminescent diodes; biology, as for example for the preparation of luminescent probes.
    Type: Grant
    Filed: September 17, 2008
    Date of Patent: May 26, 2015
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE
    Inventors: Marion Giraud, Renaud Demadrille, Marinella Mazzanti, Eugen Sorin Andreiadis
  • Publication number: 20150141640
    Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
    Type: Application
    Filed: January 26, 2015
    Publication date: May 21, 2015
    Inventors: Carl M. Blumenfeld, Harry B. Gray, Robert H. Grubbs, Karn Sorasaenee
  • Publication number: 20150133645
    Abstract: Described are bifunctional NOTA-based derivatives capable of conjugating with alginate and with metal ions, as well as NOTA-alginate conjugates which can be labeled with stable or radioactive metal ions. Also described are conjugation methods of the bifunctional NOTA-based linker with alginate, and methods of using radiometal-labeled NOTA-alginate conjugates or other radio-labeled alginate conjugates as imaging reagents.
    Type: Application
    Filed: January 22, 2015
    Publication date: May 14, 2015
    Inventors: Fuqiang Ruan, Thomas L. Deckwerth, Martin D. Meglasson
  • Patent number: 9018318
    Abstract: A macrocycle based on ?-diketimines, a process for preparing the inventive macrocycle, an uncharged macrocyclic dimetallic complex based on the inventive macrocycle, and a process for preparing the uncharged macrocyclic dimetallic complex, the use of the uncharged macrocyclic dimetallic complex as a polymerization catalyst in the polymerization of carbon dioxide with one or more epoxides, a process for preparing polycarbonates by reacting carbon dioxide with one or more epoxides in the presence of the inventive uncharged macrocyclic dimetallic complex, and a polycarbonate prepared by the process according to the invention.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: April 28, 2015
    Assignee: BASF SE Corporation
    Inventors: Peter Deglmann, Anna Katharina Brym, Bernhard Rieger, Maximilian Lehenmeier, Stephan Klaus
  • Patent number: 9012630
    Abstract: The invention relates to a method for producing manganese complex compounds of the general formula (1), wherein M, X, L, z, Y and q are defined as in claim 1.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: April 21, 2015
    Assignee: Clariant International Ltd.
    Inventors: Gerd Reinhardt, Michael Best, Christian Sidot
  • Patent number: 8968789
    Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: March 3, 2015
    Assignees: California Institute of Technology, Children's Hospital of Los Angeles
    Inventors: Carl M. Blumenfeld, Harry B. Gray, Robert H. Grubbs, Karn Sorasaenee
  • Publication number: 20150051392
    Abstract: The present invention relates to compounds that are useful as metal ligands and which contain a moiety capable of binding to a biological entity and methods of making these compounds. These compounds are of interest as they can be bound to a biological entity and then coordinated with a suitable metallic radionuclide. The coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging.
    Type: Application
    Filed: December 6, 2012
    Publication date: February 19, 2015
    Applicant: The University of Melbourne
    Inventors: Paul Donnelly, Brett Paterson
  • Publication number: 20150045506
    Abstract: A method for producing a polypeptide, includes at least one native ligation step using a peptide functionalized with a selenium group. The selenium peptides and compounds are also described.
    Type: Application
    Filed: March 18, 2013
    Publication date: February 12, 2015
    Applicants: UNIVERSITE LILLE 2 DROIT ET SANTE, INSTITUT PASTEUR DE LILLE
    Inventors: Oleg Melnyk, Laurent Raibaut, Nathalie Ollivier
  • Publication number: 20150038672
    Abstract: Targeting agents are derived from coupling together formed imaging amino acids or formed multi-modal, multi-chelating metal, multi-dye imaging agents, or combinations of these, that may be conjugated directly, or activated, or attached to linkers to which targeting groups, such as peptides, proteins, antibodies, aptamers, or small molecule inhibitors, may be conjugated in the final steps of the synthesis to form a wide variety of TMIAs.
    Type: Application
    Filed: August 1, 2014
    Publication date: February 5, 2015
    Applicant: Rochester Institute of Technology
    Inventors: Hans F. Schmitthenner, Stephanie Beach, Chelsea Weidman, Taylor Barrett
  • Patent number: 8945514
    Abstract: The invention relates to contrast agents for magnetic resonance imaging comprising a chelating ligand and a transition metal ion, said ligand carrying a substituent capable of reacting chemically or biochemically with a target substance while bringing about a change in the spin state.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: February 3, 2015
    Assignees: Centre National de la Recherche Scientifique, Ecole Normale Superieure de Lyon
    Inventor: Jens Hasserodt
  • Patent number: 8921349
    Abstract: Macrocycle containing carbamate compounds that inhibit HIV proteolytic enzymes and processes for preparing them are described. Compositions and methods for treating a patient infected with HIV are described.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: December 30, 2014
    Assignee: Purdue Research Foundation
    Inventor: Arun K. Ghosh
  • Publication number: 20140377177
    Abstract: The present application discloses compositions and methods of synthesis and use of 18F or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may be directly or indirectly attached to the targeting molecule. In other embodiments, the 18F or 19F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The disclosed methods and compositions allow the simple and reproducible labeling of molecules at very high efficiency and specific activity in 30 minutes or less. In preferred embodiments, the labeled molecule may be used for imaging in a subject without purification after labeling.
    Type: Application
    Filed: May 8, 2014
    Publication date: December 25, 2014
    Inventors: Christopher A. D'Souza, William J. McBride, David M. Goldenberg
  • Patent number: 8911710
    Abstract: Intravascular contrast agents are provided by Gd-chelates modified so as to comprise an amino acid unit attached to the chelate via a linker group suitably selected from C2-4alkylene and C3-5alkynylene. The chelates may be used as an intravascular contrast agent for MRI. Certain embodiments demonstrate enhanced relaxivity and good levels of signal enhancement.
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: December 16, 2014
    Assignees: Agency for Science, Technology and Research, Nanyang Technological University
    Inventors: Roderick Wayland Bates, Xavier Golay, Changtong Yang
  • Publication number: 20140363376
    Abstract: In some aspects, the present invention provides novel ligands, which may be used to make novel dual-modality imaging agents, for example, for PET and MRI imaging. In further aspects, by the present disclosure also provides methods of use and methods of preparation of the novel ligands, metal complexes, and imaging agents thereof.
    Type: Application
    Filed: June 6, 2014
    Publication date: December 11, 2014
    Applicant: Board of Regents, The University of Texas System
    Inventors: Xiankai SUN, Amit Kumar, Zoltan Kovacs
  • Patent number: 8901294
    Abstract: The present invention relates to a magnetic resonance imaging (MRI) contrast agent including a gadolinium complex, more particularly to a DO3A-tranexamic acid or its ester compound, which is represented by the Chemical Formula 1. A DO3A-tranexamic acid or its ester compound may be prepared according to the present invention and a gadolinium complex may be prepared using the compound. An MRI contrast agent including the gadolinium complex prepared according to the present invention as an active ingredient has higher relaxivity as compared to the currently commercially available contrast agent. In addition, the MRI contrast agent according to the present invention has bifunctionality of liver-specific and blood-pool contrasting effect.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: December 2, 2014
    Assignee: Kyungpook National University Industry-Academic Cooperation Foundation
    Inventors: Tae-Jeong Kim, Yong Min Chang, Hee-Kyung Kim, Sung-Wook Gu
  • Publication number: 20140342163
    Abstract: A mixture for use as a drier for air-drying an auto-oxidizable resin composition, said mixture comprising : 1,4,7-trialkyl-1,4,7-triazacyclononane (L); and, a manganese salt having the general formula Mn2+[X]n, wherein anion X is selected from PF6?, SbF6?, AsF6?, BF4?, B(C6F5)4?, Cl?, Br?, I?, NO3?, or R2COO? in which case n=2, or the anion X is SO42? in which case n=1, and wherein R2 is C1-C20 alkyl optionally substituted with heteroatoms, C6-C20 aryl optionally substituted with heteroatoms, or a polymeric residue; wherein the 1,4,7-trialkyl-1,4,7-triazacyclononane (L) is present in the mixture in an amount such that the molar ratio of L:Mn is at least 1.25:1 and more preferably at least 1.5:1.
    Type: Application
    Filed: December 17, 2012
    Publication date: November 20, 2014
    Applicant: AKZO NOBEL COATINGS INTERNATIONAL B.V.
    Inventors: Michel Daniel Meijer, Eddy Van Weelde, Joseph Theodorus Maria Van Dijk, Jitte Flapper
  • Publication number: 20140342997
    Abstract: Present invention refers to complex-forming compounds of the general formula and the use and preparation thereof.
    Type: Application
    Filed: December 28, 2012
    Publication date: November 20, 2014
    Applicant: STRATOXER(S) KFT.
    Inventors: G. Imre Csizmadia, Zoltan Mucsi, Andrea Narcisz Koczkas
  • Patent number: 8877157
    Abstract: The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: November 4, 2014
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Richard R. Cesati, Thomas D. Harris, Simon P. Robinson, Richard J. Looby, Edward H. Cheesman, Padmaja Yalamanchili, David S. Casebier
  • Publication number: 20140323718
    Abstract: The present invention relates to compounds that are useful as metal ligands and which can be bound to a biological entity such as a molecular recognition moiety and methods of making these compounds. Once the compounds that are bound to a biological entity are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilising the radiolabelled compounds of the invention.
    Type: Application
    Filed: December 6, 2012
    Publication date: October 30, 2014
    Inventors: Paul Donnelly, Brett Paterson
  • Patent number: 8852553
    Abstract: The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: October 7, 2014
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Richard R. Cesati, Thomas D. Harris, Simon P. Robinson, Richard J. Looby, Edward H. Cheesman, Padmaja Yalamanchili, David S. Casebier
  • Publication number: 20140295213
    Abstract: The invention relates to a method for functionalizing an electrically conductive substrate, which is not a substrate made of gold, via a layer of chemical compounds, said method comprising the following steps: a step in which the electrically conductive substrate is placed in contact with chemical compounds comprising at least a disulfide terminal group; a step in which the disulfide terminal group of said chemical compounds is electro-oxidized, causing said chemical compounds to form a layer at the surface of the electrically conductive substrate.
    Type: Application
    Filed: October 5, 2012
    Publication date: October 2, 2014
    Applicants: UNIVERSITE JOSEPH FOURIER, Commissariat a l'energie atomique et aux ene alt
    Inventors: Eric Jalaguier, Julien Buckley, Xavier Chevalier, Guy Royal
  • Publication number: 20140275521
    Abstract: A core of a cyclic structure represented by (—N—(CH2)n—)k is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound with a specific structure for producing a metal complex that exhibits a T1-reducing effect, and the resulting compound is coordinated to a metal ion that has a T1-reducing effect to obtain a metal complex that exhibits an excellent T1-reducing effect which is useful as an effective component of an MRI contrast agent and an MRI contrast agent using the same.
    Type: Application
    Filed: May 28, 2014
    Publication date: September 18, 2014
    Applicant: Canon Kabushiki Kaisha
    Inventors: Teruyuki Kondo, Hiroshi Tsujita, Zainul Abedin Siddique, Shingo Matsuki, Hiroki Miura, Hidehito Tochio, Tetsuya Matsuda, Michiko Narazaki, Hidetoshi Tsuzuki, Katsuaki Kuge, Yoshinori Tomida, Kimihiro Yoshimura, Tetsuya Yano
  • Publication number: 20140271490
    Abstract: The present invention relates to bacteria-targeted contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to bacteria targeted MRI contrast agents that can be used to detect bacteria in vivo or in vitro. In certain embodiments, the contrast agents comprise a metal chelate conjugated to at least two Zn-dipicolylamine groups.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 18, 2014
    Applicant: Northwestern University
    Inventors: Lauren M. Matosziuk, Allison S. Harney, Keith W. MacRenaris, Thomas J. Meade
  • Publication number: 20140255306
    Abstract: Compounds according to Formula I and Formula II are potent inhibitors of PSMA. Pharmaceutical compositions may include a complex of a radionuclide and a Formula I compound or a Formula II compound. Methods include using the radionuclide complex of a Formula I compound or a Formula II compound for treating or diagnosis of a disease or a condition associated with PSMA activity.
    Type: Application
    Filed: January 10, 2014
    Publication date: September 11, 2014
    Applicant: Molecular Insight Pharmaceuticals, Inc.
    Inventors: John W. BABICH, Craig ZIMMERMAN, John L. JOYAL, Genliang LU
  • Publication number: 20140248213
    Abstract: The present invention provides for heptamethine cyanine dyes that possess both nuclear and near-infrared imaging capabilities. These dyes can be used for imaging, targeting and detecting tumors in patients.
    Type: Application
    Filed: October 5, 2012
    Publication date: September 4, 2014
    Applicants: CEDARS-SINAI MEDICAL CENTER, UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Leland W. K. Chung, Dongfeng Pan
  • Publication number: 20140228541
    Abstract: The present application discloses compositions and methods of synthesis and use of 18F- or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may then be directly or indirectly attached to the targeting molecule. In other embodiments, the 18F or 19F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The disclosed methods and compositions allow the simple and reproducible labeling of molecules at very high efficiency and specific activity in 30 minutes or less. In preferred embodiments, the bifunctional chelating agent bound to 18F- or 19F-metal complex may be conjugated to the molecule to be labeled at a reduced temperature, e.g. room temperature.
    Type: Application
    Filed: March 6, 2014
    Publication date: August 14, 2014
    Applicant: Immunomedics, Inc.
    Inventors: Christopher A. D'Souza, William J. McBride, David M. Goldenberg
  • Publication number: 20140227187
    Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
    Type: Application
    Filed: February 12, 2014
    Publication date: August 14, 2014
    Applicants: Children's Hospital Of Los Angeles, California Institute of Technology
    Inventors: Carl M. Blumenfeld, Harry B. Gray, Robert H. Grubbs, Karn Sorasaenee
  • Publication number: 20140212575
    Abstract: The present invention includes a novel self-assembling nanocomposite structure comprising a shape-persistent three-dimensional cage molecule. In one aspect, binding of nanoparticles to metal coordinating groups in the cage molecule allows for the self-assembly of the nanoparticles into a nanocomposite material. The present invention further includes methods of preparing such self-assembling nanocomposite structures.
    Type: Application
    Filed: September 24, 2013
    Publication date: July 31, 2014
    Inventors: Wei Zhang, Ryan McCaffrey, Wounjhang Park, Kazunori Emoto, Yinghua Jin
  • Publication number: 20140193344
    Abstract: Provided are macrocyclic compounds having a macrocyclic core which has at least one macrocyclic donor and at least one pendant group which has at least one donor group. The macrocyclic compounds can be complexed to Fe(II) and Ni(II). The macrocyclic compounds can be used in imaging methods. For example, the compounds can be used MRI paraCEST contrast agents.
    Type: Application
    Filed: May 11, 2012
    Publication date: July 10, 2014
    Applicant: The Research Foundation of State University of New York
    Inventors: Janet R. Morrow, Pavel Tsitovich, Sarina Dorazio, Abiola Olatunde
  • Patent number: 8772475
    Abstract: A core of a cyclic structure represented by (—N—(CH2)n—)k is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound with a specific structure for producing a metal complex that exhibits a T1-reducing effect, and the resulting compound is coordinated to a metal ion that has a T1-reducing effect to obtain a metal complex that exhibits an excellent T1-reducing effect which is useful as an effective component of an MRI contrast agent and an MRI contrast agent using the same.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: July 8, 2014
    Assignee: Canon Kabushiki Kaisha
    Inventors: Teruyuki Kondo, Hiroshi Tsujita, Zainul Abedin Siddique, Shingo Matsuki, Hiroki Miura, Hidehito Tochio, Tetsuya Matsuda, Michiko Narazaki, Hidetoshi Tsuzuki, Katsuaki Kuge, Yoshinori Tomida, Kimihiro Yoshimura, Tetsuya Yano
  • Publication number: 20140187527
    Abstract: The present disclosure provides a novel class of macrocyclic compounds and their metal complexes formed with transition metal ion, lanthanide metal ions and other metal ions (e.g., Al, Ga, Y, In, Sn, Tl, Pb and Bi) and their applications in the fields of contrast agents, artificial nucleases, fluorescence probes, nuclear medicines and other biomedical applications in the therapeutics or diagnostics.
    Type: Application
    Filed: December 31, 2012
    Publication date: July 3, 2014
    Applicant: NATIONAL YANG MING UNIVERSITY
    Inventors: Cheng Allen Chang, Ren-Shyan Liu, Bhalchandra Vishnu Bhagwat
  • Publication number: 20140179918
    Abstract: Metallocorrole complexes of third row transition metals (see Formula I below) may be used as therapeutic agents, catalysts, components of oxygen detectors, and components of light emitting diodes. In particular, metallocorrole complexes of third row transition metals may be used as improved photosenitizers in photodynamic therapy; as improved catalysts in aziridination, epoxidation, and water splitting reactions; as improved in vivo imaging agents; and as improved components in the emissive layer of OLEDs. Due to their strongly sigma-donating nature, corroles are able to stabilize third row transition metals in high oxidation states. Third row transition metals are significantly more electropositive than their first and second row counterparts and may therefore act as improved catalysts.
    Type: Application
    Filed: February 10, 2014
    Publication date: June 26, 2014
    Applicant: California Institute of Technology
    Inventors: Joshua H. Palmer, Zeev Gross, Harry B. Gray
  • Patent number: 8759331
    Abstract: The present invention relates to a X-ray and gamma-photon activable compound responding to the following formula (I). The present invention also relates to methods of synthesizing a compound according to the invention, and to an aqueous or physiological solution comprising at least one compound of the invention. The present invention also concerns a method of liberating a biologically active compound, said method involving the step of irradiating at least one compound, or at least one aqueous or physiological solution according to the invention. Finally, the present invention relates to a pharmaceutical composition comprising at least one compound, or at least one aqueous or physiological solution according to the invention.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: June 24, 2014
    Assignees: Centre National de la Recherche Scientifique, Universite Paris Descartes
    Inventors: Peter Dalko, Morgane Petit, David Ogden, Guillaume Bort, Cécile Sicard
  • Publication number: 20140171637
    Abstract: A process for the preparation of complexes containing 68Ga wherein a buffer formic acid/formate in the presence of compounds capable to sequester metal cations is used in the complexion reaction.
    Type: Application
    Filed: August 10, 2012
    Publication date: June 19, 2014
    Applicant: Advamced Accelerator Applications S.A.
    Inventors: Lorenza Fugazza, Maria Azzurra Filannino, Maurizio Franco Mariani
  • Publication number: 20140148596
    Abstract: Crystalline COFs comprising a phthalocyanine moiety and a boron-containing multifunctional linking group joined by boronate ester bonds. A method for making crystalline COFs comprising Lewis acid catalyzed formation of boronate ester bonds between protected catechol subunits and multifunctional linkers comprising boronic acid groups. The COFs can be used in applications such as, for example, electronic devices.
    Type: Application
    Filed: April 7, 2011
    Publication date: May 29, 2014
    Applicant: CORNELL UNIVERSITY
    Inventors: William R. Dichtel, Eric L. Spitler
  • Publication number: 20140142298
    Abstract: The present invention embodiments relate to a compound with formula (V?) The invention also relates in certain embodiments to the synthesis method for compound (V?) and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I) The invention also relates in certain embodiments to metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.
    Type: Application
    Filed: November 13, 2013
    Publication date: May 22, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BOURGOGNE
    Inventors: Franck Denat, Pauline Desogere, Claire Bernhard, Yoann Rousselin, Frederic Boschetti
  • Patent number: 8722881
    Abstract: A tetradendate amide based macrocyclic ligand and its Fe(III) complex which act as activators of hydrogen peroxide. The synthetic methodology to develop the ligands is new, simple and provides better yield for each step of the ligand synthesis. The Fe(III)-complexes and hydrogen peroxide together are can perform several environmentally benign oxidation reactions. Organic dye bleaching, bleaching of pulp and paper effluent and N-oxide synthesis may be performed using the newly developed catalyst and hydrogen peroxide. Alcohol oxidation and alkene epoxidation may also be performed using the catalysts and hydrogen peroxide.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: May 13, 2014
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Anindya Ghosh, Shane Z. Sullivan, Samuel L. Collom, Sharon Pulla
  • Publication number: 20140113382
    Abstract: The invention relates to the use of a construct for the detection of an analyte using surface enhanced spectroscopic techniques. The construct includes linked surfaces, where the link is formed by a linker providing a fixed inter-surface separation between the linked surfaces, wherein the linker is a linking compound, and at least one of the surfaces is the surface of a nanoparticle. The linking compound is suitable for interacting with the analyte. The linking compound may be a cucurbituril. The surface enhanced spectroscopic technique may be surface enhanced Raman spectroscopy (SERS).
    Type: Application
    Filed: June 24, 2011
    Publication date: April 24, 2014
    Applicant: CAMBRIDGE ENTERPRISE LIMITED
    Inventors: Richard William Taylor, Jeremy John Baumberg, Sumeet Mahajan, Tung-Chun Lee, Oren Alexander Scherman, Setu Kasera, Roger Coulston
  • Publication number: 20140073780
    Abstract: The present invention describes dual-modality probes. In particular, the present invention discloses hydroxyapatite specific multimeric bisphosphonate dual-modality MRI and optical probes.
    Type: Application
    Filed: September 11, 2012
    Publication date: March 13, 2014
    Inventors: Kumar Ranjan Bhushan, Preeti Misra
  • Publication number: 20140065075
    Abstract: Described herein is a contrast agent for administration to a subject. The contrast agent includes a targeting portion that includes an unchelated aminocarboxylate functional group; a metal ion bound to a metal-complexable portion; and a linker joining the targeting portion and the metal-complexable portion of the contrast agent. The portion that is not bound to a metal ion is for binding to necrotic tissue in the subject.
    Type: Application
    Filed: April 17, 2012
    Publication date: March 6, 2014
    Applicant: RF THERAPEUTICS INC.
    Inventors: Jidong Zhang, Kenneth Curry
  • Patent number: 8628978
    Abstract: A compound of formula (I) is provided: wherein: R1 is an optionally substituted 2-(1-azathiaxanthone); each —R2 is independently of the formula —CH2—C(?O)—R4, wherein R4 is an amino acid or a salt thereof, attached to the remainder of R2 through the nitrogen atom of the amino group; and R3 is hydrogen or a C1-6 alkyl group; or wherein: R1 is an optionally substituted 2-(1-azaxanthone); each R2 is independently an optionally substituted glutaric or succinic acid, or a salt or ester thereof; and R3 is hydrogen or a C1-6 alkyl group.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: January 14, 2014
    Assignee: University of Durham
    Inventors: David Parker, Robert Pal
  • Publication number: 20140005091
    Abstract: The invention relates to the use of manganese or iron complexes which, as well as a tetraoxolene unit, contain two macrocyclic, N-containing ligands, especially cyclen or cyclam ligands, in washing and cleaning compositions in the form of granules or powder or solution or suspension for bleaching of coloured stains both on textiles and on hard surfaces. The invention also relates to washing and cleaning compositions which comprise such complexes as bleach activators and to the use thereof for textile washing or for dishwashing detergents and other uses in personal care and other areas.
    Type: Application
    Filed: February 3, 2012
    Publication date: January 2, 2014
    Applicant: CLARIANT INTERNATIONAL LTD.
    Inventors: Gerd Reinhardt, Werner Janitschek, Miriam Ladwig
  • Publication number: 20130337997
    Abstract: A compound represented by formula (1): wherein Y1 to Y4 each independently represent any one of the following groups: in which R? represents a hydrogen atom or a monovalent hydrocarbon group; P1 to P4 each independently represents a group of atoms necessary for forming a heterocyclic ring together with each Y1 to Y4 and the two carbon atoms adjacent to Y1 to Y4, respectively; P5 and P6 each independently represents a group of atoms necessary for forming a cyclic skeleton together with the carbon atom to which Z1 bonds or Z2 bonds; P1 and P2, P2 and P6, P6 and P4, P4 and P3, P3 and P5, and P5 and P1 may further combine with each other to form a ring; Q1 and Q2 each independently represents a connecting group or a direct binding; and Z1 and Z2 each independently represent any one of the following groups; —NR?2, —OR?, —SR?, —PR?2 in which R? represents a hydrogen atom or a monovalent hydrocarbon group, and when plural R?s are present, these plural R?s may be the same or different from each other.
    Type: Application
    Filed: August 19, 2013
    Publication date: December 19, 2013
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Tadafumi MATSUNAGA, Nobuyoshi KOSHINO, Hideyuki HIGASHIMURA, Yusuke ISHII
  • Publication number: 20130317196
    Abstract: The present invention relates to a triazanonane derivative indicated by the chemical formula 1 below, or a pharmaceutically acceptable salt thereof, and a method for preparing same, and the triazanonane derivative according to the present invention forms a complex with a metal-fluoride and displays an effect of increasing the labeling efficiency up to 78-90% when labeling F-18, thus enabling use in various radioactive medicine labeling (In the chemical formula 1, R1, R2, A. E. X, n and m are as defined in the present description.
    Type: Application
    Filed: February 1, 2012
    Publication date: November 28, 2013
    Applicant: SNU R&DB FOUNDATION
    Inventors: Jae Min Jeong, Dinesh Shetty, Dong Soo Lee, June-Key Chung, Myung Chul Lee
  • Patent number: 8580231
    Abstract: The present invention relates to compositions and methods for imaging with magnetic resonance contrast agents. In particular, the present invention provides targeted contrast agents for selective imaging.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: November 12, 2013
    Assignee: Northwestern University
    Inventors: Preeti A. Sukerkar, Jiyoun Lee, Teresa K. Woodruff, Thomas J. Meade