Heavy Metal Or Aluminum Containing Patents (Class 540/465)
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Publication number: 20110177002Abstract: The invention pertains to a compound for detecting cell death. According to the invention, the compound comprises a cyclic polyamine unit for the complexation of a bi- or trivalent metal ion. The compound of the invention may contain a reporting tag like fluorescein or a radioisotope including substituent.Type: ApplicationFiled: July 14, 2009Publication date: July 21, 2011Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFTInventors: Sabine Zitzmann-Kolbe, Ulrike Bauder-Wuest, Michael Eisenhut, Doerte Oltmanns
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Publication number: 20110165075Abstract: The invention provides a family of agents that target integrins, which can be used as imaging agents and/or therapeutic agents. The agents can be used to image angiogenesis, inflammation or other physiological processes in a subject.Type: ApplicationFiled: March 13, 2009Publication date: July 7, 2011Inventors: Milind Rajopadhye, Guojie Ho, Bohumil Bednar, Le T. Duong, Paul J. Coleman
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Publication number: 20110144477Abstract: The invention concerns a system capable of generating a magnetic indication B.sub.o comprising gradients (Gx, Gy, Gz) in certain directions, transmitting ratio frequency wave pulse sequences (RF) perpendicular to B.sub.o in a range of adjustable frequencies, and detecting electromagnetic signals received from a body part (4). The method consists in: injecting a contrast product in said body part, capable of being temporarily fixed in an observed zone (1), and comprising and element capable of causing chemical displacement of a resonance frequency of water hydrogen protons; exciting said body part, using a radio frequency wave pulse sequence: in a range of frequencies adjusted on the basis of the magnetic induction B.sub.o and the chemical displacement for some of said waves: detecting the electromagnetic signals received in said body part, substantially corresponding to the magnetic resonance signals of the protons of the observed zone having undergone the chemical displacement.Type: ApplicationFiled: July 6, 2010Publication date: June 16, 2011Inventors: Jean-Michel Franconi, Sylvain Miraux, Eric Thiaudiere, Paul Canioni
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Publication number: 20110137025Abstract: The disclosure provides metal organic frameworks useful for sensing, gas sorption, microelectronics and switches.Type: ApplicationFiled: June 5, 2009Publication date: June 9, 2011Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Omar M Yaghi, Qiaowei Li, Ognjen S Miljanic, Wenya Zhang, James Frasere Stoddart
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Publication number: 20110118459Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to novel near-infrared dyes that are photostable and resistant to quenching. The dyes belong to a novel family of squaraine rotaxanes, and they are particularly well-suited for use in biological applications. Also disclosed are methods of synthesizing the dyes and methods of using the dyes.Type: ApplicationFiled: November 16, 2009Publication date: May 19, 2011Applicants: University of Notre Dame du Lac, Molecular Targeting Technologies, Inc.Inventors: Bradley Smith, Arunkumar Easwaran
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Publication number: 20110112289Abstract: The invention relates to the use of compounds comprising at least one 2-(1H-tetrazol-5-yl)pyridine unit, of formula (I) below: as ligands for lanthanides and, more especially, as organic chromophores for complexing these elements. It also relates to lanthanide complexes using these compounds as complexing organic chromophores, and to new compounds containing one or more 2-(1H-tetrazol-5-yl)pyridine units, which are useful as ligands for lanthanides and, in particular, as organic chromophores for complexing these elements. Applications: photonics and optoelectronics, especially for forming light-emitting devices such as electroluminescent diodes; biology, as for example for the preparation of luminescent probes.Type: ApplicationFiled: September 17, 2008Publication date: May 12, 2011Inventors: Marion Giraud, Renaud Demadrille, Marinella Mazzanti, Eugen Sorin Andreiadis
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Publication number: 20110105703Abstract: The invention relates to a novel iron complex bearing a cyclic amine as ligand; and a process for the production of polymers by polymerizing a radical-polymerizable monomer in the presence of the iron complex and a radical generator. The invention aims at providing a process by which a polymer having a chemically convertible functional group at the end can be produced from a radical-polymerizable monomer and which permits the production of a block copolymer and a process for recovering, after polymerization, an iron complex into a solvent at a high recovery ratio. The aim can be solved by providing a novel iron complex, a process for producing a polymer in the presence of a radical polymerization initiator by using the iron complex as the polymerization catalyst, a process for the production of a block copolymer which is subsequent to the polymerization for producing the above polymer, and a process for recovering the iron complex easily and simply.Type: ApplicationFiled: March 10, 2008Publication date: May 5, 2011Applicant: DIC CorporatioInventors: Hidetomo Kai, Akane Sasamoto, Hitoshi Hayakawa
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Publication number: 20110092806Abstract: The invention concerns compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium. The invention also concerns methods for obtaining said compounds, screening methods capable of selecting such compounds for chemical synthesis thereof and their diagnostic applications, in particular in PET, PET/IRM, PET CT imaging.Type: ApplicationFiled: October 9, 2006Publication date: April 21, 2011Applicant: GUEREBETInventors: Marc Port, Claire Corot, Thierry Gautheret
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Patent number: 7917188Abstract: A method for mapping a physico-chemical parameter using a chemical exchange saturation transfer contrast agent in Magnetic Resonance Imaging is used with agents having only one exchangeable entity pool, e.g. proton pool, by applying two different RF frequencies for pre-saturation of the contrast agent.Type: GrantFiled: April 21, 2006Date of Patent: March 29, 2011Assignee: Koninklijke Philips Electronics N.V.Inventors: Rene Theodorus Wegh, Jeroen Alphons Pikkemaat, Nicolaas Petrus Willard
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Patent number: 7906105Abstract: The present invention relates to contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to MRI contrast agents that are activated in the presence of zinc(II) (e.g., resulting in a brighter image).Type: GrantFiled: August 23, 2007Date of Patent: March 15, 2011Assignee: Northwestern UniversityInventors: Jody L. Major, Thomas J. Meade
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Publication number: 20110038805Abstract: The present invention relates to novel compounds of formula (I) and (II), compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and MR spectroscopy (MRS).Type: ApplicationFiled: April 17, 2009Publication date: February 17, 2011Inventors: Andreas Meijer, Oskar Axelsson, Anders Brathe, Andreas Olsson, John Henrik Johansen, Duncan George Wynn
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Publication number: 20110039815Abstract: In one embodiment the present invention relates to a method of treating cancerous cells in a mammal comprising the steps of administering to the cancerous cells an effective amount of a cyclic amine wherein the cyclic amine contains sulfur or nitrogen and the structure includes an interchealted metal ion.Type: ApplicationFiled: June 14, 2006Publication date: February 17, 2011Inventors: Wiley J. Youngs, Claire A. Tessier, Doug A. Medvetz, Michael J. Taschner
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Publication number: 20110033379Abstract: Radio-labeled materials, e.g., compounds and compositions, methods of making the radio-labeled materials, and applications of the same are disclosed. For example, novel solid-state methods are disclosed that produce radio-labeled compositions that include a reactive, but stable radio-labeled compound in a polar anhydrous solvent. The radio-labeled compounds can be readily conjugated with a variety of ligands.Type: ApplicationFiled: August 29, 2007Publication date: February 10, 2011Inventors: John V. Frangioni, Preeti Misra
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Publication number: 20110028713Abstract: A core of a cyclic structure represented by (—N—(CH2)n—)k is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound with a specific structure for producing a metal complex that exhibits a T1-reducing effect, and the resulting compound is coordinated to a metal ion that has a T1-reducing effect to obtain a metal complex that exhibits an excellent T1-reducing effect which is useful as an effective component of an MRI contrast agent and an MRI contrast agent using the same.Type: ApplicationFiled: November 28, 2008Publication date: February 3, 2011Applicants: KYOTO UNIVERSITY, CANON KABUSHIKI KAISHAInventors: Teruyuki Kondo, Hiroshi Tsujita, Zainul Abedin Siddique, Shingo Matsuki, Hiroki Miura, Hidehito Tochio, Tetsuya Matsuda, Michiko Narazaki, Hidetoshi Tsuzuki, Katsuaki Kuge, Yoshinori Tomida, Kimihiro Yoshimura, Tetsuya Yano
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Publication number: 20110021765Abstract: The invention provides a paramagnetic lanthanide (III) complex comprising a lanthanide (III) ion and a polydentate ligand wherein the polydentate ligand comprises one or more fluorine atoms in which the distance of at least. one of the fluorine atoms to the lanthanide ion is less than 7, said polydentate ligand not being a DPTA bisamide of p-CF3-aniline.Type: ApplicationFiled: April 11, 2008Publication date: January 27, 2011Inventors: David Parker, Padma Kanthi Senanayake
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Publication number: 20110015059Abstract: A compound represented by formula (1): wherein Y1 to Y4 each independently represent any one of the following groups: in which R? represents a hydrogen atom or a monovalent hydrocarbon group; P1 to P4 each independently represent a group of atoms necessary for forming a heterocyclic ring together with each of Y1 to Y4 and the two carbon atoms adjacent to each of Y1 to Y4, respectively; P5 and P6 each independently represent a group of atoms necessary for forming a cyclic skeleton together with the carbon atom to which Z1 bonds or Z2 bonds and the two carbon atoms adjacent to the carbon atom to which Z1 bonds or Z2 bonds; P1 and P2, P2 and P6, P6 and P4, P4 and P3, P3 and P5, and P5 and P1 may further combine with each other to form a ring; Q1 and Q2 each independently represent a connecting group or a direct binding; and Z1 and Z2 each independently represent any one of the following groups; —NR?2, —OR?, —SR?, —PR?2 in which R? represents a hydrogen atom or a monovalent hydrocarbon group, and wheType: ApplicationFiled: September 5, 2008Publication date: January 20, 2011Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Tadafumi Matsunaga, Nobuyoshi Koshino, Hideyuki Higashimura, Yusuke Ishii
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Publication number: 20100322855Abstract: Substituted 1,4,7-triazacyclononane-N,N?,N?-triacetic acid and 1,4,7,10-tetraazacyclcododecane-N,N?,N?,N??-tetraacetic acid compounds with a pendant amino or hydroxyl group, metal complexes thereof, compositions thereof, and methods of making and use in diagnostic imaging and treatment of cellular disorders.Type: ApplicationFiled: August 20, 2010Publication date: December 23, 2010Applicant: Illinois Institute of TechnologyInventor: Hyun-soon Chong
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Publication number: 20100292465Abstract: Novel N-heterocyclic carbene ligand precursors, N-heterocyclic carbene ligands and N-heterocyclic metal-carbene complexes are provided. Metal-carbene complexes comprising N-heterocyclic carbene ligands can be chiral, which are useful for catalyzing enantioselective synthesis. Methods for the preparation of the N-heterocyclic carbene ligands and N-heterocyclic metal-carbene complexes are given.Type: ApplicationFiled: February 15, 2008Publication date: November 18, 2010Applicant: University of Florida Research Foundation, Inc.Inventors: Adam Steven Veige, Mathew S. Jeletic, Roxy J. Lowry, Khalil A. Abboud
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Patent number: 7820783Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.Type: GrantFiled: October 6, 2008Date of Patent: October 26, 2010Assignee: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing
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Publication number: 20100247448Abstract: The present invention relates to a ligand for metals, in particular lanthanides, of the general formula (I) A corresponds to an organic acid radical, to an alkyl or aryl ester. R1 and R2 correspond, individually and independently of one another, to an H, an alkyl radical or an aryl radical. Z1 and Z2, identical or different, are of the general formula (ZA) or (ZB): G represents an O, N, P, S or a C substituted independently with an H, an alkyl radical or an aryl radical. R3 to R8 correspond, individually and independently of one another, to an H, an alkyl radical or an aryl radical. The present invention also relates to co-ordinating complexes of the general formula: [Ln(L)(H2O)n] wherein Ln is a lanthanide, L corresponds to a ligand, as well as the grafting thereof to a molecule of interest and their preparation method. The present invention relates moreover to a contrast agent and a pharmaceutical composition including at least one ligand and/or complex and/or molecule of interest.Type: ApplicationFiled: January 19, 2007Publication date: September 30, 2010Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUEInventors: Christelle Gateau, Marinella Mazzanti, Aline Nonat
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Publication number: 20100236448Abstract: The present invention relates to an aqueous solution composition (water-based ink composition) containing a water-soluble naphthalocyanine coloring matter represented by the following formula (1): (wherein, M represents a hydrogen atom, a metal atom, a metal oxide, a metal hydroxide or a metal halide, X represents a carbonyl group or a sulfonyl group, W1 to W4 are each independently a hydrogen atom, an ionic hydrophilic group or the like, at least one of W1 to W4 is a group other than a hydrogen atom, and n represents an integer number of 1 to 24, respectively) or a salt thereof, and a novel naphthalocyanine coloring matter; and said compound is useful as a near-infrared ray absorbent because it has a high absorption in the near-infrared region, and it is useful as an near-infrared ray absorbing water-based ink because it has an excellent storage stability in aqueous solution.Type: ApplicationFiled: October 30, 2008Publication date: September 23, 2010Applicant: Nippon Kayaku Kabushiki KaishaInventors: Takaaki Kurata, Takashi Yoneda, Takafumi Fujii, Tadayuki Kiyoyanagi, Koji Hirota
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Patent number: 7790394Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.Type: GrantFiled: October 6, 2008Date of Patent: September 7, 2010Assignee: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing
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Publication number: 20100184971Abstract: An object of the invention is to modify the surface of a metal nanoparticle with a cyclic phenylazomethine having a multi-ion sensing capability, thereby making the sensing of multiple substances possible. The metal nanoparticles of the invention are characterized by being modified with a cyclic phenylazomethine compound having a structure represented by Chemical Formula 1.Type: ApplicationFiled: May 8, 2008Publication date: July 22, 2010Applicant: National Institute For Materials ScienceInventors: Masayoshi Higuchi, Ryo Shomura, Dirk G. Kurth
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Publication number: 20100178246Abstract: A compound of Formula I, a pharmaceutically acceptable salt, or solvate thereof: complexes with metals such as rhenium, technetium, and others to provide a complex for imaging tissues or treating disease, particularly where the metal is radioactive. Such complexes are specific to PSMA protein and can therefore be used in imaging or treating cancer of the prostate and other tissue where the protein is expressed.Type: ApplicationFiled: December 4, 2009Publication date: July 15, 2010Inventors: John W. Babich, Craig Zimmerman, John Joyal, Kevin P. Maresca, Genliang Lu, Shawn Hillier
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Publication number: 20100148663Abstract: Imidazo[1,2-f]phenanthridine compounds are provided. The compounds have a twisted aryl moiety further substituted by alkyl having four or more atoms. The compounds may be used in organic light emitting devices, particularly as emissive dopants, providing devices with improved efficiency, stability, and manufacturing. In particular, the compounds provided herein may be used in blue devices having high efficiency.Type: ApplicationFiled: December 7, 2009Publication date: June 17, 2010Applicant: Universal Display CorporationInventors: Jui-Yi TSAI, Walter Yeager, Jason Brooks, Scott Beers, Gregory S. Kottas, Edward Barron, Raymond Kwong
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Publication number: 20100081799Abstract: A compound of the formula: wherein R1 is selected from H, methyl, ethyl, carboxyl protecting groups and hydrophilic moieties, R2 and R3 are independently selected from H, methyl, ethyl and carboxyl protecting groups, R4 is selected from H, methyl, ethyl, hydrophilic moieties and carboxyl protecting groups, and R5 is an aryl, heteroaryl, alkyl or a combination of these groups and is substituted with a carbonyl group, an aminooxy group or a functional group suitable for participating in a cycloaddition reaction. The compounds of the invention may be useful as bifunctional chelating agents which allow chemoselective attachment to targeting molecules.Type: ApplicationFiled: December 10, 2007Publication date: April 1, 2010Inventors: Sebastian Knör, Armin Modlinger, Hans-Jürgen Wester, Horst Kessler
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Publication number: 20100055043Abstract: In certain aspects, the present invention relates to metal coordinating complexes for use as imaging contrast agents. For instance, in some embodiments, the present invention is directed to an imaging contrast agent including a metal chelator and a halogen-substituted phenol, thiophenol, resorcinol, thioresorcinol, or dithioresorcinol derivative.Type: ApplicationFiled: October 30, 2007Publication date: March 4, 2010Inventor: Dennis A. Moore
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Patent number: 7663301Abstract: Novel metal porphyrin compositions useful as organic phosphors are provided. The novel compositions are prepared from commercially available porphyrin-containing starting materials. In one instance a novel palladium-containing porphyrin composition having a number average molecular weight of greater than 12,000 grams per mole was prepared from 5,10,15,20-tetrakis(3?,5?-di(hydroxy)phenyl)-21H-23H-porphyrin by reaction first with palladium(II) acetylacetonate, followed by reaction with 2-bromo-2-methylpropionyl bromide, and subsequent group transfer reaction of the alpha-bromo ester groups with 9,9-dioctyl-2-vinylfluorene in the presence of CuBr as a radical initiator. The product polymer exhibited a number average molecular weight of 12,884 grams per mole, a weight average molecular weight of 14,338 grams per mole, and a robust red phosphorescent emission.Type: GrantFiled: January 6, 2006Date of Patent: February 16, 2010Assignee: General Electric CompanyInventors: Kyle Erik Litz, James Anthony Cella, Qing Ye
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Publication number: 20090318681Abstract: Provided is a metal complex represented by the following formula (A-1) or (B-1) as a metal complex useful for a redox reaction catalyst or some other article that is excellent in heat resistance and acid resistance:Type: ApplicationFiled: December 11, 2007Publication date: December 24, 2009Applicant: Sumitomo Chemical Company LimitedInventors: Tadafumi Matsunaga, Nobuyoshi Koshino, Hideyuki Higashimura
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Publication number: 20090306368Abstract: A polynuclear complex having two or more metal atoms and/or metal ions per one ligand of the general formula (I): (wherein, Q1 and Q2 represent each independently a divalent heterocyclic group optionally having a substituent.Type: ApplicationFiled: November 26, 2007Publication date: December 10, 2009Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Hiroyasu Sugiyama, Hideyuki Higashimura, Nobuhiko Akino
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Publication number: 20090297454Abstract: The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.Type: ApplicationFiled: May 20, 2009Publication date: December 3, 2009Inventors: Heiko SCHIRMER, Hanns-Joachim Weinmann, Johannes Platzek, Ludwig Zorn, Bernd Misselwitz, Joerg Meding, Heribert Schmitt-Willich, Thomas Brumby
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Publication number: 20090240050Abstract: A method of preparing a macrocyclic metal cyanine. The method comprises the step of providing a corresponding macrocyclic metal-free cyanine compound dissolved in a solvent and adding a metal reagent thereto. The metal reagent is highly soluble in the solvent and typically comprises one or more organic ligands.Type: ApplicationFiled: May 31, 2009Publication date: September 24, 2009Inventors: Simone Charlotte Vonwiller, Scott Matthew Starling, Damon Donald Ridley, Lachlan Everett Hall, Simon Fielder, Graciel Gonzaga, Kia Silverbrook, Paul Lapstun
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Patent number: 7582280Abstract: The invention provides radiopharmaceuticals for diagnostic and therapeutic applications, conjugates of antioxidants with metal chelating ligands, intermediate compounds, methods of making such radiopharmaceuticals, ligands, and intermediate compounds, and kits for preparing the radiopharmaceutical complexes.Type: GrantFiled: July 8, 2008Date of Patent: September 1, 2009Assignee: Bracco International B.V.Inventors: Ramachandran S. Ranganathan, Helen Fan, Michael F. Tweedle, Rolf E. Swenson
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Publication number: 20090214441Abstract: The invention relates to chelate compounds which can be used in MRI, the chelates being intended to be conveyed by lipophilic transporters, such as lipid nanoparticles or liposomes. The invention also relates to compounds comprising, in association, these chelates and these transporters, if appropriate connected via chemical bonding groups, and to their use in diagnostic imaging, it being possible for this association additionally to comprise biological targeting markers, denoted biovectors.Type: ApplicationFiled: March 24, 2006Publication date: August 27, 2009Applicant: GUERBETInventor: Marc Port
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Patent number: 7579338Abstract: The radiation sensitization potential of a candidate compound can be screened by determine its ability to generate one or more reactive oxygen species under appropriate conditions. Compounds determined to have radiation sensitization potential are employed in methods for treating atheroma, tumors and other neoplastic tissue as well as other conditions that typically responsive to radiation sensitization.Type: GrantFiled: August 16, 2006Date of Patent: August 25, 2009Assignee: Pharmacyclics, Inc.Inventors: Jonathan L. Sessler, Darren Magda, Greg Hemmi, Tarak Mody
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Patent number: 7579463Abstract: The invention describes crown ether chelators, including crown ethers having the formula:Type: GrantFiled: October 2, 2006Date of Patent: August 25, 2009Assignee: Life Technologies CorporationInventors: Kyle R. Gee, Vladimir V. Martin
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Publication number: 20090202521Abstract: A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111Li or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.Type: ApplicationFiled: March 6, 2007Publication date: August 13, 2009Applicant: MDS (Canada) Inc.Inventors: Zoltan Kovaks, Garry E. Kiefer, Corinne Bensimon, A. Dean Sherry, Gyula Tircso
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Publication number: 20090169479Abstract: The present invention relates to a compound of formula (II) chosen from (IIa) and (IIb) or of formula (VI) chosen from (VIa) and (VIb) of following general formulae: in which: X1, X2, X3, X4 and X5 represent, independently of one another, L-Y in which L represents a C1-C3 alkyl group, preferably (CH2), with n=1 to 3, Y represents —CONH2, —CO—NR7R8 or —NR7-CO—R8, or an isomer, an enantiomer or a diastereoisomer of these or their mixtures or a pharmaceutically acceptable salt of the compounds of formulae (VIa) and (VIb). It also relates to a complex of these compounds with a paramagnetic metal or a radionuclide and their use in diagnostic methods.Type: ApplicationFiled: October 9, 2006Publication date: July 2, 2009Applicant: GUERBETInventor: Marc Port
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Publication number: 20090156801Abstract: This invention concerns novel labeling reactants based on azacycloalkanes, wherein a suitable group is linked to the molecule allowing introduction of the said molecules to bioactive molecules in solution or on solid phase.Type: ApplicationFiled: May 4, 2007Publication date: June 18, 2009Applicant: NXP B.V.Inventor: Jari Hovinen
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Publication number: 20090155829Abstract: Methods of activating an apo-peroxidase are provided. The methods include the steps of providing a solution comprising an apo-peroxidase and a heme choline ester, hydrolyzing the heme choline ester with a choline esterase, and converting the apo-peroxidase to active peroxidase. The methods disclosed herein also provide for detecting the presence of an analyte in a sample. The methods include providing a binder capable of specifically binding the analyte wherein the binder is attached to a solid surface, applying the sample to the solid surface under conditions that permit binder-analyte binding, adding a choline esterase-conjugated binder that binds to the analyte, adding an apo-peroxidase, a heme choline ester, a peroxide, and a peroxide-activated signal generator, and detecting the signal produced by the peroxide-activated signal generator. An associated kit and components are also provided.Type: ApplicationFiled: December 18, 2007Publication date: June 18, 2009Applicant: GENERAL ELECTRIC COMPANYInventors: Thomas Pirrie Treynor, Anup Sood, Sean Richard Dinn
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Patent number: 7547689Abstract: Compositions comprising motexafin gadolinium, as well as methods for using these compositions in the treatment of brain metastases, are described herein.Type: GrantFiled: March 24, 2006Date of Patent: June 16, 2009Assignee: Pharmacyclics, Inc.Inventors: Jonathan L. Sessler, Darren Magda, Norbert Purro, Tarak D. Mody, Greg Hemmi
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Publication number: 20090131656Abstract: The invention relates to the formation of synthesized fractal constructs and the methods of chemical self-assembly for the preparation of a non-dendritic, nano-scale, fractal constructs or molecules. More particularly, the invention relates to fractal constructs formed by molecular self-assembly, to create synthetic, nanometer-scale fractal shapes. In an embodiment, a nanoscale Sierpinski hexagonal gasket is formed. This non-dendritic, perfectly self-similar fractal macromolecule is comprised of bisterpyridine building blocks that are bound together by coordination to 36 Ru and 6 Fe ions to form a nearly planar array of increasingly larger hexagons around a hollow center.Type: ApplicationFiled: May 10, 2007Publication date: May 21, 2009Inventors: George R. Newkome, Charles N. Moorefield
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Patent number: 7527652Abstract: Mixtures of (A) from 55 to 65 mol % of erythro-dithiol of formula erythro-IV: and (B) from 35 to 45 mol % of threo-dithiol of formula threo-IV or threo-IV?: and their corresponding alkali metal salts and ammonium salts, are useful for treating animal hides.Type: GrantFiled: September 10, 2004Date of Patent: May 5, 2009Assignee: BASF AktiengesellschaftInventors: Holger Buehler, Joaquim Henrique Teles, Gunther Pabst, Tilman Luedecke Taeger
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Publication number: 20090098047Abstract: The present invention is directed to bioconjugates of complexes represented by the formula: wherein R, R?, R1, R?1, R2, R?2, R3, R?3, R4, R?4, R5, R?5, R6, R?6, R7, R?7, R8, R?8, R9, R?9, M, X, Y, Z and n are defined herein for use as contrast agents in diagnostic imaging.Type: ApplicationFiled: August 4, 2008Publication date: April 16, 2009Applicants: Inotek Pharmaceuticals, Kereos, Inc.Inventors: William L. Neumann, Dennis P. Riley, Randy H. Weiss, Susan L. Henke, Patrick J. Lennon, Karl W. Aston
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Publication number: 20090083912Abstract: The present invention relates to dyes of formula (1), wherein Pc is a phthalocyanine of formula (2), Me is a metal, [MePc] is a phthalocyanine-metal complex of formula (3), M+ is an inorganic or organic cation, R1 is hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted aralkyl or unsubstituted or substituted aryl, and R2 is hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted aralkyl or unsubstituted or substituted aryl, and n and m are each independently of the other 0, 1, 2, 3, 4, 5, 6, 7 or 8, the sum of (n +m) being a number 5, 6, 7 or 8, and also to mixtures thereof, to processes for the preparation thereof and to the use thereof in dyeing or printing natural, semi-synthetic or synthetic material.Type: ApplicationFiled: June 28, 2006Publication date: April 2, 2009Inventor: Urs Lehmann
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Publication number: 20090082324Abstract: The present invention is directed to metal chelating conjugates for use as metallopharmaceutical diagnostic or therapeutic agents. Specifically, conjugates of the present invention include one or more carriers, a linker, and metal coordinating moiety comprising a resorcinol, thioresorcinol, or dithioresorcinol derivative through which the metal coordinating moiety is bonded to the linker.Type: ApplicationFiled: February 20, 2007Publication date: March 26, 2009Inventor: Dennis A. Moore
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Publication number: 20090042764Abstract: Hard surface cleaning agents comprising a macrocyclic compound of the general formula L: wherein each of n1, n2 and n3 independently represents 1 or 2; and hard surface cleaning agents comprising a transition metal complex of the general formula (I): [MLaXb]cY??(1) wherein M represents a metal selected from the group consisting of manganese, iron, cobalt, copper, ruthenium, molybdenum, and combinations thereof; X represent a neutral or anionic ligand; Y represents a non-complex-bound anion; a represents 1 or 2; each of b and c independently represents a number of 0 to 6, with the proviso that b and c are selected such that the complex is neutral based on M, X and Y; and L represents a macrocyclic ligand of the general formula L; and methods of cleaning hard surfaces therewith.Type: ApplicationFiled: December 8, 2006Publication date: February 12, 2009Applicant: Henkel AG & Co. KGaAInventors: Pavel Gentschev, Arndt Kessler, Maren Jekel, Johannes Zipfel, Christian Nitsch, Doris Dahlmann, Steve Doring
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Publication number: 20090010845Abstract: The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is a gadolinium. Another aspect of the invention relates to a compound comprising three biotin moieties and a pharmaceutical agent covalently bound to a heterocyclic core. In certain embodiments, the pharmaceutical agent is an antibiotic, antiviral, or radionuclide. Another aspect of the present invention relates to a method of treating disease involving administering the compounds of the invention to a mammal. Another aspect of the present invention relates to a method of acquiring a magnetic resonance image using the compounds of the invention.Type: ApplicationFiled: September 10, 2008Publication date: January 8, 2009Applicant: The General Hospital CorporationInventors: David R. Elmaleh, Timothy M. Shoup, Alan J. Fischman
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Patent number: 7470469Abstract: A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the portion of the substrate by bonding to the plasma polymerized functionality. The functionalities can be carboxylate, amine, or sulfate groups and/or polyethylene glycol and can optionally include crosslinking groups.Type: GrantFiled: July 5, 2007Date of Patent: December 30, 2008Assignee: Advanced Cardiovascular Systems Inc.Inventors: Eugene T. Michal, Murthy Simhambhatla, Charles D. Claude
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Patent number: RE42152Abstract: Polyamine macrocyclic compounds, e.g. of 10 to 15 ring members and 3 to 6 ring amine nitrogens, linked through methylene groups to an aromatic moiety, show high selective activity against HIV.Type: GrantFiled: December 16, 1992Date of Patent: February 15, 2011Assignee: Genzyme CorporationInventors: Gary J. Bridger, Sreenivasan Padmanbhan, Renato Skerlj, David M. Thornton