Nitrogen Or Acyclic Chalcogen Bonded Directly To The Hetero Ring (e.g., Cyclic Carbonates, Etc.) Patents (Class 540/65)
  • Methanesulfonate salts of abiraterone-3-esters and recovery of salts of abirater one-3-esters from solution in methyl tert-butyl ether
    Patent number: 8076474
    Abstract: A salt of a compound of formula (I) may be made with methanesulfonic acid. The salt and salts with other acids may be prepared by recovering from methyl tert-butyl ether (MTBE).
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: December 13, 2011
    Assignee: BTG International Limited
    Inventor: Neil John Hunt
  • PROCESS FOR THE PREPARATION OF PREGNANE DERIVATIVES
    Publication number: 20100331539
    Abstract: A stereoselective and enrichment process for the preparation of ciclesonide is described.
    Type: Application
    Filed: March 12, 2009
    Publication date: December 30, 2010
    Applicant: FARMABIOS S.P.A.
    Inventors: Filippo La Loggia, Matteo Curti, Claudio Gianluca Pozzoli
  • PROCESS FOR PREPARING BUDESONIDE
    Publication number: 20090259037
    Abstract: A process is described for preparing budesonide which comprises the steps of: a) preparing an aqueous hydrochloric acid solution; b) reacting 16?-hydroxyprednisolone and butyraldehyde within the solution prepared in step a), in an inert atmosphere; c) quenching the reaction of step b) with water. The process of the invention enables the ratio between the A and B epimers of budesonide to be controlled.
    Type: Application
    Filed: April 6, 2009
    Publication date: October 15, 2009
    Inventors: Roberto Lenna, Maurizio Montoro
  • 11?-long-chain-substituted 19-nor-17?-pregna-1,3,5(10)-trien-17?-ols with a 21,16?-lactone ring
    Patent number: 7119082
    Abstract: This invention relates to new 19-nor-17?-pregna-1,3,5(10)-trien-17?-ols with a 21,16?-lactone ring with a long-chain substituent in 11?-position of general formula II in which R11 means a straight-chain alkyl radical with 6 to 17 carbon atoms, and R3 and R13 have the meanings that are explained in more detail in the description. The compounds act in a tissue-selective manner as pure antiestrogens and are suitable for the production of pharmaceutical agents because of these properties.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: October 10, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: Gerd Mueller, Jens Hoffmann, Karl-Heinrich Fritzemeier, Alexander Hillisch
  • 11?-Substituted 19-nor-17-?-pregna-1,3,5(10)-trien-17?-ols with a 21,16?-lactone ring
    Patent number: 6956031
    Abstract: This invention relates to new 19-nor-17?-pregna-1,3,5(10)-trien-17?-ols with a 21,16?-lactone ring with a long-chain substituent in 11?-position of general formula II in which R11 is a long-chain alkyl radical that has a nitrogen atom that can be substituted in terminal position with a perfluoroalkyl group. The compounds act in a tissue-selective manner as pure antiestrogens and are suitable for the production of pharmaceutical agents because of these properties.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: October 18, 2005
    Assignee: Schering Aktiengesellschaft
    Inventors: Alexander Hillisch, Walter Elger, Rolf Bohlmann, Jens Hoffmann
  • 17.beta.-(2-oxo-tetrahydrofuranyl)-thio- substituted androstane derivatives
    Patent number: 6114318
    Abstract: Compounds of the androstane series are described having the formula (I) and solvates thereof in which R.sub.1 and R.sub.2 are the same or different and each represents hydrogen or C.sub.1-6 alkyl; R.sub.3 and R.sub.4 are the same or different and each represents hydrogen or halogen; and ##STR1## represents a single or a double bond. Compounds of formula (I) and their solvates are useful as anti-inflammatory or anti-allergic agents.
    Type: Grant
    Filed: June 24, 1998
    Date of Patent: September 5, 2000
    Assignee: Glaxo Group Limited
    Inventors: Keith Biggadike, Panayiotis Alexandrou Procopiou