Halogen Attached Indirectly To The Cyclopentanohydrophenanthrene Ring System By Acyclic Nonionic Bonding Patents (Class 540/68)
  • Publication number: 20130225804
    Abstract: The invention relates to a process for preparing the corticosteroid ciclesonide, used for the treatment of respiratory complaints, in epimerically pure form of formula 1:
    Type: Application
    Filed: February 15, 2013
    Publication date: August 29, 2013
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Carsten PUDER, Joern MERTEN, Heinz-Peter SCHMITT, Markus THUMERER, Bjoern WEYELL
  • Patent number: 4695625
    Abstract: A process for the preparation of 16,17 acetals of pregnane derivatives by trans-ketalization of 16,17-acetonides is described.In the instance of the preparation of 16.alpha.,17.alpha.-butylidenedioxy-11.beta.,21-dihydroxypregna-1,4-diene- 3,20-dione, a compound having useful therapeutic properties, known also as budesonide, it is possible to obtain the more active epimer with high selectivity and remarkable economic advantages in comparison with the known methods.New 16,17 acetals of pregnane derivatives, which can be prepared by the method of the invention, are also described.
    Type: Grant
    Filed: May 30, 1985
    Date of Patent: September 22, 1987
    Assignee: Sicor Societa Italiana Corticosteroidi S.p.A.
    Inventor: Peter Macdonald