The Lactone Ring Shares A Ring Carbon With Two Other Cyclos Of The Polycyclo Ring System (e.g., Peri-fused, Etc.) Patents (Class 540/75)
  • NEUROACTIVE 13, 17-SUBSTITUTED STEROIDS AS MODULATORS FOR GABA TYPE-A RECEPTORS
    Publication number: 20140249120
    Abstract: The present disclosure is generally directed to neuroactive 13,17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.
    Type: Application
    Filed: February 27, 2014
    Publication date: September 4, 2014
    Applicant: WASHINGTON UNIVERSITY
    Inventors: Douglas Covey, Xin Jiang
  • Prodrugs of (2R)-2-propyloctanoic acid for the treatment of stroke
    Patent number: 7495029
    Abstract: Disclosed are prodrugs of (2R)-2-propyloctanoic acid, and pharmaceutical compositions comprising them, which may be effective in modulating multiple events in the biochemical cascade of stroke. Also disclosed are methods of treating patients who have had a stroke, or are at risk of stroke, by administering the compounds or compositions of the invention.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: February 24, 2009
    Assignee: Merck & Co., Inc
    Inventors: Benito Munoz, Joseph E. Payne, Petpiboon Prasit, Thomas S. Reger, Nicholas D. Smith