The Hetero Ring Is A Lactone (i.e., Containing -c(=x)-o- As Part Of The Ring, Wherein X Is Chalcogen) Patents (Class 540/72)
The lactone ring shares at least three ring members with one other cyclo of the polycylo ring system (i.e., bridged) (Class 540/73)
The lactone ring shares a ring carbon with two other cyclos of the polycyclo ring system (e.g., peri-fused, etc.) (Class 540/75)
  • Process for the production of 3-oxo-pregn-4-ene-21,17-carbolactones by the metal-free oxidation of 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanes
    Patent number: 8658788
    Abstract: This invention relates to processes for the production of 3-oxo-pregnane-21,17-carbolactones of formula II as well as 3-oxo-pregn-4-ene-21,17-carbolactones of formula III by the metal-free oxidation of 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanes of formula I In addition, the invention relates to the dichloromethane hemisolvate of 6?,7?;15?,16?-dimethylene-3-oxo-17?-pregnan-5?-ol-21,17-carbolactone (IV) as such as well as to a process for the production of drospirenone.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: February 25, 2014
    Assignee: Bayer Pharma AG
    Inventors: Carsten Seilz, Hartmut Seba
  • NGCYCLOARTANONE DERIVATIVES WITH ANTICANCER ACTIVITY
    Publication number: 20120077777
    Abstract: The present invention relates to a compound of following formula (I): or to a pharmaceutically acceptable salt thereof, as well as to pharmaceutical compositions including same and to the use thereof as a drug, in particular for treating a proliferative disease such as cancer.
    Type: Application
    Filed: May 20, 2010
    Publication date: March 29, 2012
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), PIERRE FABRE MEDICAMENT
    Inventors: Christophe Long, Yves Guminski, Fadila Derguini, Joséphine Beck, Frédéric Cantagrel
  • 9-ALPHA ESTRATRIENE DERIVATIVES AS ER-BETA SELECTIVE LIGANDS FOR THE PREVENTION AND TREATMENT OF INTESTINAL CANCER
    Publication number: 20110178052
    Abstract: Use of 9?-estra-1,3,5(10)-triene derivatives of formula (I) for the prevention and treatment of intestinal cancer, in particular adenoma and adenocarcinoma of the duodenum, ileum, colon, and rectum.
    Type: Application
    Filed: July 9, 2009
    Publication date: July 21, 2011
    Applicant: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Karl-Heinrich Fritzemeier, Patrick Diel, Torsten Hertrampf
  • 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols with a 21,16&agr;-lactone ring
    Patent number: 6670347
    Abstract: This invention relates to new 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols with a 21,16&agr;-lactone ring of formula II, process for their production and pharmaceutical preparations that contain these compounds as well as 17&agr;-cyanomethylated estra-1,3,5(10)-trienes, which produce intermediate products on the way to the 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols. The 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols produce novel selective estrogens, which contrast to standard estrogens, such as estradiol, show a preference for one of the two known estrogen receptors, estrogen receptor alpha.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: December 30, 2003
    Assignee: Schering AG
    Inventors: Gerd Müller, Uwe Kollenkirchen, Dirk Kosemund, Karl-Heinrich Fritzemeier, Walter Elger
  • 19-nor-17alpha-pregna-1,3,5 (10) -trien-17beta-ols with a 21, 16alpha-lactone ring
    Publication number: 20020156271
    Abstract: This invention relates to new 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols with a 21,16&agr;-lactone ring of formula II, 1
    Type: Application
    Filed: September 27, 2001
    Publication date: October 24, 2002
    Applicant: JENAPHARM GmbH & Co. KG
    Inventors: Gerd Muller, Uwe Kollenkirchen, Dirk Kosemund, Karl-Heinrich Fritzemeier, Walter Elger
  • Digitalis-like compounds
    Patent number: 5874423
    Abstract: A human cataractous lens nuclei methanolic extract characterized in that it comprises substances having a molecular weight lower than 3000 daltons, inhibiting ATP hydrolysis by Na.sup.+,K.sup.+ -ATPase having affinity to the ouabain binding site on the enzyme and cross-reacting with an antibody directed against digoxin. Compounds of the general formula are disclosed: ##STR1## or of the general formula: ##STR2## in which R is hydrogen, an amino acid, a di- or tripeptide or a mono-, di- or trisaccharide. Pharmaceutical preparations and methods of using the compounds are also disclosed.
    Type: Grant
    Filed: September 12, 1996
    Date of Patent: February 23, 1999
    Assignee: Yissum Research Development Co. of the Hebrew University of Jerusalem
    Inventors: David Lichtstein, Joseph Deutsch, Irit Gati
  • Sterol disulfates and methods of use
    Patent number: 5079239
    Abstract: Novel sterol disulfates have been isolated from the marine sponge Petrosia weinbergii. These compounds, and derivatives thereof, are useful antiviral compounds. One of these compounds is active against the AIDS virus and exhibits immunosuppressive activity.
    Type: Grant
    Filed: February 16, 1990
    Date of Patent: January 7, 1992
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: H. Howard Sun, Sue S. Cross, Frank Koehn, Malika Gunasekera