Abstract: A method of sterilizing a pharmaceutical composition containing a suspension of a pharmaceutical comprises rapidly heating the pharmaceutical composition from ambient temperature to an elevated temperature, maintaining it at or above the elevated temperature for a period of time, and rapidly cooling the pharmaceutical composition to ambient temperature.
Abstract: The invention provides a process for the sterilization of a powdered form of a glucocorticosteroid, sterile glucocorticosteroids, sterile formulations containing glucocorticosteroids and use thereof in the treatment of an allergic and/or inflammatory condition of the nose or lungs.
Type:
Grant
Filed:
January 29, 1999
Date of Patent:
May 21, 2002
Assignee:
AstraZeneca AB
Inventors:
Ann-Kristin Karlsson, Cheryl Larrivee-Elkins, Ove Molin
Abstract: A compound having a formula selected from ##STR1## wherein A and B are selected from the group consisting of ##STR2## K and K' are selected from the group consisting of ##STR3## n is 2 or 3 and R.sub.1 is an ether or ester residue.
Abstract: A compound of the formula ##STR1## wherein R is=0 or ##STR2## and the rings A and B are selected from the group consisting of ##STR3## K is oxo or a protector group of oxo of the formula ##STR4## n is 2 or 3 and R.sub.1 is an ether or ester remainder, K' is oxo or a protector oxime, hydrazone or semicarbazone group and the wavy lines symbolize an isomer mixture, a process for their preparation and their use as intermediates.
Type:
Grant
Filed:
March 9, 1995
Date of Patent:
April 2, 1996
Assignee:
Roussel Uclaf
Inventors:
Jean Buendia, Remi Chauvin, Michel Vivat