Abstract: A method of sterilizing a pharmaceutical composition containing a suspension of a pharmaceutical comprises rapidly heating the pharmaceutical composition from ambient temperature to an elevated temperature, maintaining it at or above the elevated temperature for a period of time, and rapidly cooling the pharmaceutical composition to ambient temperature.
Abstract: The invention provides a process for the sterilization of a powdered form of a glucocorticosteroid, sterile glucocorticosteroids, sterile formulations containing glucocorticosteroids and use thereof in the treatment of an allergic and/or inflammatory condition of the nose or lungs.
Type:
Grant
Filed:
January 29, 1999
Date of Patent:
May 21, 2002
Assignee:
AstraZeneca AB
Inventors:
Ann-Kristin Karlsson, Cheryl Larrivee-Elkins, Ove Molin