The Hetero Ring Shares The 9,11-positions Of The Cyclopentanohydrophenanthrene Ring System Patents (Class 540/87)
Halogen bonded directly to the cyclopentanohydrophenanthrene ring system (Class 540/88)
Having -c(=x)-, wherein x is chalcogen, bonded directly to the cyclopentanohydrophenanthrene ring system (Class 540/89)
  • Process for the preparation of fluorosteroids
    Patent number: 6794503
    Abstract: Described herein is a process for the preparation of 6&agr;-fluorosteroids of formula (I), in which R is chosen from H, OH and an alkyl group with from 1 to 4 carbon atoms and R′ is a carboxyalkyl group with from 1 to 4 carbon atoms in the alkyl chain, comprising the selective fluorination at the 6&agr;-position by treatment of the compound of formula (III), wherein R and R′ are as defined above, with an electrophilic fluorinating agent.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: September 21, 2004
    Assignee: Farmabios S.r.l.
    Inventors: Filippo La Loggia, Marco Da Col
  • Process for preparing 16 &agr;-methyl-steroids
    Patent number: 6194565
    Abstract: Intermediates for the compound of the formula
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: February 27, 2001
    Assignee: Hoechst Marion Roussel
    Inventors: Jean Buendia, Patrick Roussel, Michel Vivat
  • Method of preparing 16.alpha., 17.alpha.-dialkylated steroids
    Patent number: 6040468
    Abstract: 16.alpha., 17.alpha.-dialkylated steroids are prepared by reacting a 16.alpha.-alkyl-17(20)-enyl-20-silyl ether with an alkylating agent and an enol silyl ether cleaving agent in a suitable solvent.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: March 21, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventor: Raymond E. Conrow
  • Process for preparing 16.alpha.-methyl-steroids
    Patent number: 5731447
    Abstract: A process for the preparation of a compound of the formula ##STR1##
    Type: Grant
    Filed: June 10, 1996
    Date of Patent: March 24, 1998
    Assignee: Roussel Uclaf
    Inventors: Jean Buendia, Patrick Roussel, Michel Vivat
  • Intermediates for the preparation of 6.alpha., 9.alpha.-difluoro steroids
    Patent number: 5556965
    Abstract: A compound of the formula ##STR1## wherein R is hydrogen or an ester remainder, X is hydrogen or fluorine and Y combined with the doted lines represents ##STR2## or X is hydrogen and and Y combined with the dotted lines is ##STR3## and R.sub.1 is the remainder of an enol ether or ester.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: September 17, 1996
    Assignee: Roussel Uclaf
    Inventors: Jean-Yves Godard, Philippe Mackiewicz, Denis Prat, Christian Richard
  • 10-thioethyl-steroids
    Patent number: 5202314
    Abstract: A compound of the formula ##STR1## wherein R is selected from the group consisting of alkyl, alkenyl and alkynyl of up to 4 carbon atoms, Y is .dbd.O or ##STR2## R.sub.1 is hydrogen or acyl, n is 0, 1 or 2, D is .dbd.O or ##STR3## and A and B form a second carbon-carbon or an .alpha.-epoxy useful for aromatase inhibition and a process and intermediates for their preparation.
    Type: Grant
    Filed: May 21, 1992
    Date of Patent: April 13, 1993
    Assignee: Roussel Uclaf
    Inventors: Jean-Francois Gourvest, Dominique Lesuisse
  • 11.beta.,17.alpha.-Dihydroxy-17.beta.-cyano-androstanes
    Patent number: 4831131
    Abstract: Using cyanohydrin intermediates, 17-keto steroids are transformed to corticoids and 17.alpha.-acyl progesterones.
    Type: Grant
    Filed: March 5, 1986
    Date of Patent: May 16, 1989
    Assignee: The Upjohn Company
    Inventor: Verlan H. VanRheenen
  • 16.alpha.-methylated.DELTA.17(20)-corticoids
    Patent number: 4704455
    Abstract: C.sub.16 -unsaturated corticoids are readily transformed to the corresponding 16.alpha.-methyl-17.alpha.-hydroxy corticoids by use of a .DELTA..sup.17 (.sup.20)-20-silyl ether.
    Type: Grant
    Filed: April 18, 1985
    Date of Patent: November 3, 1987
    Assignee: The Upjohn Company
    Inventors: Verlan H. VanRheenen, Joel E. Huber
  • Novel 17-substituted steroids
    Patent number: 4647410
    Abstract: Novel 17-(formamidosulfonylmethylene)-steroids of the formula ##STR1## useful as intermediates for the novel 17-(isocyanosulfonylmethylene)-steroids of the formula ##STR2## which are useful intermediates for 21-hydroxy-20-keto-.DELTA..sup.16 -steroids and 20-keto-.DELTA..sup.16 -steroids.
    Type: Grant
    Filed: April 27, 1984
    Date of Patent: March 3, 1987
    Assignee: Gist-Brocades N.V.
    Inventors: Albert M. van Leusen, Adriaan M. van Leusen
  • Ethynylation of 16-methyl-17-keto steroids
    Patent number: 4618456
    Abstract: The process of the present invention transforms 16.alpha.- or 16.beta.-methyl-17-keto steroids (I) to the corresponding 17.alpha.-ethynyl-17.beta.-hydroxy-16.alpha.- or 16.beta.-methyl steroids (II) without epimerization and loss of stereochemistry of the 16.alpha.- or 16.beta.-methyl group.
    Type: Grant
    Filed: April 26, 1984
    Date of Patent: October 21, 1986
    Assignee: The Upjohn Company
    Inventor: Joseph M. Timko
  • Ethynylation of 16-methylene-17-keto steroids
    Patent number: 4614621
    Abstract: The process of the present invention transforms 16-methylene-17-keto steroids (I) to the corresponding 17.alpha.-ethynyl-17.beta.-hydroxy-16-methylene steroids (II).
    Type: Grant
    Filed: April 20, 1984
    Date of Patent: September 30, 1986
    Assignee: The Upjohn Company
    Inventor: Verlan H. VanRheenen