Having -c(=x)-, Wherein X Is Chalcogen, Bonded Directly To The Cyclopentanohydrophenanthrene Ring System Patents (Class 540/89)
  • Patent number: 10239913
    Abstract: Compounds and methods of synthesizing oxysterols are provided. The compounds and methods provided allow the oxysterol to be safely produced at a high yield. The compounds and methods provided can produce the oxysterol in a stereoselective manner. The method comprises reacting a diol with borane and hydrogen peroxide to form the oxysterol or a pharmaceutically acceptable salt, hydrate or solvate thereof.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: March 26, 2019
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Roger E. Harrington, Jerbrena C. Jacobs, Damodaragounder Gopal, Ke-Qing Ling, Marco Burello
  • Patent number: 9611288
    Abstract: Compounds and methods of synthesizing oxysterols are provided. The compounds and methods provided allow the oxysterol to be safely produced at a high yield. The compounds and methods provided can produce the oxysterol in a stereoselective manner.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: April 4, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Roger E. Harrington, Jerbrena C. Jacobs, Damodaragounder Gopal, Ke-Qing Ling, Marco Burello
  • Publication number: 20130211069
    Abstract: The present invention provides an improved process for the preparation of 17-desoxy corticosteroid derivatives in a single chemical step by reacting the 17-hydroxy starting material with an excess of Trimethylsilyl Iodide. The present invention is specifically advantageous in preparing 17-desoxy corticosteroid derivatives having one or more halogen groups at positions 2, 6, 7 or 9 of the corticosteroid such as Clocortolone of Desoximetasone.
    Type: Application
    Filed: July 20, 2011
    Publication date: August 15, 2013
    Applicant: Taro Pharmaceutical Industries Ltd.
    Inventors: Simon Cherniak, Rosa Cyjon, Ilana Ozer, Igor Nudelman
  • Patent number: 5731447
    Abstract: A process for the preparation of a compound of the formula ##STR1##
    Type: Grant
    Filed: June 10, 1996
    Date of Patent: March 24, 1998
    Assignee: Roussel Uclaf
    Inventors: Jean Buendia, Patrick Roussel, Michel Vivat
  • Patent number: 5120723
    Abstract: Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-ammobutyric acid/benzodiazepine receptor-chloride ionpore (GBR) complex.
    Type: Grant
    Filed: May 10, 1990
    Date of Patent: June 9, 1992
    Assignee: University of Southern California
    Inventors: Kelvin W. Gee, Michael B. Bolger
  • Patent number: 4990612
    Abstract: Disclosed is a process for the production of a .DELTA..sup.17(20) -steroid of the formula ##STR1## which comprises starting with a 16-unsaturated corticoid of the formula ##STR2## and contacting the 16-unsaturated corticoid (I) with a methylating agent in the presence of a copper catalyst and a silylating agent.
    Type: Grant
    Filed: December 5, 1988
    Date of Patent: February 5, 1991
    Assignee: The Upjohn Company
    Inventors: Verlan H. VanRheenen, Joel E. Huber
  • Patent number: 4948533
    Abstract: The present invention relates to 21-(3-carboxy-1-oxopropoxy) -17.alpha.-hydroxy-11.alpha.-(3,3-dimethyl-1-oxobutoxy)pregna-1,4-diene-3, 20 dione and pharmaceutically acceptable salts thereof which are useful steroid prodrugs.
    Type: Grant
    Filed: February 16, 1989
    Date of Patent: August 14, 1990
    Assignee: The Upjohn Company
    Inventors: John M. Braughler, Edward D. Hall, Wendell Wierenga, John M. McCall
  • Patent number: 4929395
    Abstract: C.sub.16 -unsaturated corticoids are readily transformed to the corresponding 16.alpha.-methyl-17.alpha.-hydroxy corticoids by use of a .DELTA..sup.17 (.sup.20)-20-silyl ether.
    Type: Grant
    Filed: November 14, 1986
    Date of Patent: May 29, 1990
    Assignee: The Upjohn Company
    Inventors: Verlan H. VanRheenen, Joel E. Huber
  • Patent number: 4824990
    Abstract: Copolyester plasticizers useful for the formulation of PVC refrigerator gaskets which exhibit improved resistance to migration and marring and improved processing characteristics are provided. The copolyesters are obtained by reacting an acid component consisting of a mixture of a benzene dicarboxylic acid (or anhydride or methyl ester thereof) and an aliphatic C.sub.5-12 saturated dicarboxylic acid (or methyl ester) with an alcohol component consisting of a mixture of neopentyl glycol and ethylene glycol. An aliphatic C.sub.6-13 saturated monofunctional alcohol or aliphatic C.sub.6-13 saturated monocarboxylic acid terminating agent is also included in the reaction.
    Type: Grant
    Filed: April 23, 1987
    Date of Patent: April 25, 1989
    Assignee: National Distillers and Chemical Corporation
    Inventors: William J. Mertz, Robert J. Braun
  • Patent number: 4613463
    Abstract: This invention discloses an improved process for the production of corticoids from 17.alpha.-hydroxy steroids utilizing peroxymonosulfate.
    Type: Grant
    Filed: November 1, 1984
    Date of Patent: September 23, 1986
    Assignee: The Upjohn Company
    Inventor: Clifford E. Sacks
  • Patent number: RE35517
    Abstract: Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-ammobutyric acid/benzodiazepine receptor-chloride ionpore (GBR) complex.
    Type: Grant
    Filed: November 23, 1992
    Date of Patent: May 20, 1997
    Assignee: University of Southern California
    Inventors: Kelvin W. Gee, Michael B. Bolger, Nancy C. Lan