Phosphorus Or Sulfur In Ionically Bonded Moiety Patents (Class 544/110)
  • Patent number: 10344281
    Abstract: Functionally-modified oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3? and/or 5?-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: July 9, 2019
    Assignee: SAREPTA THERAPEUTICS, INC.
    Inventors: Gunnar J. Hanson, Dwight D. Weller, Bao Zhong Cai, Ming Zhou
  • Patent number: 10047200
    Abstract: A dendritic polymer, a dendritic polymer monomer, and a hyperbranched copolymer are described. The dendritic polymer monomer has a structure denoted by Z?-(Q)n-Y, wherein Z? represents a structure denoted by the following formula (a) and/or formula (b), Q represents a dendritic constitutional repeating unit of the dendritic polymer monomer, n represents the generation number of the dendritic polymer monomer, and is an integer within a range of 2-6, Y represents a group that contains SO3? and COO?, R14-R16 can be identical to or different from each other, and are H or C1-C5 alkyl respectively. The monomer can be used as a copolymerizable monomer for preparing a hyperbranched polymer applicable to oil fields, the obtained hyperbranched polymer can be used as an inhibiting filtrate reducer for drilling fluid, flocculating agent, encapsulating agent, heat-resistant and salinity-resistant polymer flooding agent, and thickening agent for fracturing liquid, etc.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: August 14, 2018
    Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, SINOPEC ZHONGYUAN OILFIELD SERVICE CORPORATION DRILLING ENGINEERING RESEARCH INSTITUTE
    Inventor: Zhonghua Wang
  • Patent number: 9475894
    Abstract: A dendritic polymer, a dendritic polymer monomer, and a hyperbranched copolymer are described. The dendritic polymer monomer has a structure denoted by Z?-(Q)n-Y, wherein Z? represents a structure denoted by the following formula (a) and/or formula (b), Q represents a dendritic constitutional repeating unit of the dendritic polymer monomer, n represents the generation number of the dendritic polymer monomer, and is an integer within a range of 2-6, Y represents a group that contains SO3? or COO?, R14-R16 can be identical to or different from each other, and are H or C1-C5 alkyl respectively. The monomer can be used as a copolymerizable monomer for preparing a hyperbranched polymer applicable to oil fields, the obtained hyperbranched polymer can be used as an inhibiting filtrate reducer for drilling fluid, flocculating agent, encapsulating agent, heat-resistant and salinity-resistant polymer flooding agent, and thickening agent for fracturing liquid, etc.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: October 25, 2016
    Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, SINOPEC ZHONGYUAN OILFIELD SERVICE CORPORATION DRILLING ENGINEERING RESEARCH INSTITUTE
    Inventor: Zhonghua Wang
  • Publication number: 20130109572
    Abstract: Disclosed are compositions and methods of preparing compositions of active herbicidal ingredients. Also disclosed are methods of using the compositions described herein to improve herbicide delivery and efficacy, enhance herbicidal penetration, reduce herbicide volatility and drift, diminish environmental damage from herbicides, decrease water solubility and volatility of herbicides, and introduce additional biological function to herbicides.
    Type: Application
    Filed: July 6, 2011
    Publication date: May 2, 2013
    Applicant: The Board of Trustees of the University of Alabama
    Inventors: Juliusz Pernak, Julia Shamshina, Praczyk Tadeusz, Anna Syguda, Dominika Janiszewska, Marcin Smiglak, Gabriela Gurau, Daniel T. Daly, Robin D. Rogers
  • Publication number: 20120065394
    Abstract: The invention relates to the use of salts of compounds of the formula (1) and amines of the formula (2) where R1 is C1- to C30-alkyl, C2- to C30-alkenyl, C6- to C30-aryl or C7- to C30-alkylaryl, R2 is C1- to C30-alkyl, C2- to C30-alkenyl, C6- to C30-aryl or C7- to C30alkylaryl, or an optionally heteroatom containing organic radical having from 1 to 30 carbon atoms, and R3 and R4 are each independently hydrogen, C1- to C30-alkyl, C2- to C30-alkenyl, C6- to C30-aryl or C7- to C30-alkylaryl, or an optionally heteroatom containing organic radical having from 1 to 30 carbon atoms, where R3 and R4 can also form, with the inclusion of the nitrogen atom, a ring having from 5 to 7 ring atoms.
    Type: Application
    Filed: November 18, 2011
    Publication date: March 15, 2012
    Applicant: CLARIANT FINANCE (BVI) LIMITED
    Inventors: Dirk LEINWEBER, Michael FEUSTEL
  • Patent number: 7842804
    Abstract: The present invention relates to salts comprising pyrrolidinium, triazolinium, piperidinium or morpholinium cations that can have substituents thereon and alkyltrifluorophosphate anions, to processes for preparation thereof and to the use thereof, in particular for the preparation of ionic liquids.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: November 30, 2010
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Nikolai (Mykola) Ignatyev, German Bissky, Helge Willner
  • Publication number: 20100234592
    Abstract: The invention relates to the use of salts of compounds of the formula (1) and amines of the formula (2) where R1 is C1- to C30-alkyl, C2- to C30-alkenyl, C6- to C30-aryl or C7- to C30-alkylaryl, R2 is C1- to C30-alkyl, C2- to C30-alkenyl, C6- to C30-aryl or C7- to C30-alkylaryl, or an optionally heteroatom containing organic radical having from 1 to 30 carbon atoms, and R3 and R4 are each independently hydrogen, C1- to C30-alkyl, C2- to C30-alkenyl, C6- to C30-aryl or C7- to C30-alkylaryl, or an optionally heteroatom containing organic radical having from 1 to 30 carbon atoms, where R3 and R4 can also form, with the inclusion of the nitrogen atom, a ring having from 5 to 7 ring atoms.
    Type: Application
    Filed: January 10, 2007
    Publication date: September 16, 2010
    Inventors: Dirk Leinweber, Michael Feustel
  • Publication number: 20090182141
    Abstract: The present invention is directed to novel processes for the preparation of sulfamide derivatives, useful in the treatment of epilepsy and related disorders.
    Type: Application
    Filed: January 6, 2009
    Publication date: July 16, 2009
    Inventors: Ahmed Abdel-Magid, Steven J. Mehrman, Caterina Ferraro
  • Patent number: 7297735
    Abstract: This invention relates to polycarbonate compositions comprising: (A) at least one polycarbonate comprising repeating units derived from a dihydroxyaromatic compound or a dihydroxyaliphatic compound of the formula HO—Y—OH; and (B) at least one salt prepared from the reaction of one or more acidic phosphorus-containing compounds and one or more hindered amine light stabilizers. The polycarbonate compositions exhibit improved hydrolytic stability.
    Type: Grant
    Filed: March 5, 2003
    Date of Patent: November 20, 2007
    Assignee: Eastman Chemical Company
    Inventors: Jason Clay Pearson, Douglas Stephens McWilliams, Gether Irick, Jr., Max Allen Weaver
  • Patent number: 7038084
    Abstract: Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: May 2, 2006
    Assignee: G.D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • Patent number: 6972343
    Abstract: The invention concerns drug precursors with antimalarial effect, characterised in that it consists in quaternary bis-ammonium salts of general formula (I) wherein A and A?, identical or different, are respectively either a group A1 and A?1 of formula (1) wherein n=2 to 4; R?1 is hydrogen, C1-C5 alkyl, optionally substituted by an aryl, a hydroxy, an alkoxy, wherein the alkyl comprises 1 to 5 C, or aryloxy and W is halogen or a nucleofuge group; or a group A2 which represents formyl-CHO, or acetyl-COCH3.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: December 6, 2005
    Assignee: CNRS
    Inventors: Henri Vial, Marie-Laure Ancelin, Valerie Vidal, Michele Calas, Jean-Jacques Bourguignon, Eric Rubi
  • Patent number: 6403826
    Abstract: A description is given of compounds of the formula in which the general symbols are as defined in claim 1, and of their zirconium, bismuth and calcium salts, and of the salts with the compounds of the formula II in which the general symbols are as defined in claim 1, as corrosion inhibitors in coating compositions for protecting metallic surfaces.
    Type: Grant
    Filed: September 11, 2000
    Date of Patent: June 11, 2002
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Adalbert Braig, Andreas Kramer, Jean-Pierre Wolf, Markus Frey
  • Patent number: 6352985
    Abstract: A benzimidazole compound represented by the formula (I): wherein R3 is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl group, or their pharmaceutically acceptable salts. Because of their blood sugar-depressing effect or PDE5 inhibitory effect, these compounds or salts thereof are useful as medicines for treating impaired glucose tolerance, diabetes, diabetic complications, syndrome of insulin resistance, hyperlipidemia, atherosclerosis, cardiovascular disorders, hyperglycemia, or hypertension; or stenocardia, hypertension, pulmonary hypertension, congestive heart failure, glomerulopathy, tubulointerstitial disorders, renal failure, atherosclerosis, angiostenosis, distal angiopathy, cerebral apoplexy, chronic reversible obstructions, allergic rhinitis, urticaria, glaucoma, diseases characterized by enteromotility disorders, impotence, diabetic complications, nephritis, cancerous cachexia, or restenosis after PTCA.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: March 5, 2002
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Noritsugu Yamasaki, Takafumi Imoto, Yoshiyuki Murai, Takahiro Hiramura, Teruo Oku, Kouzou Sawada
  • Patent number: 5980619
    Abstract: A description is given of compounds of the formula ##STR1## in which the general symbols are as defined in claim 1, and of their zirconium, bismuth and calcium salts, and of the salts with the compounds of the formula II ##STR2## in which the general symbols are as defined in claim 1, as corrosion inhibitors in coating compositions for protecting metallic surfaces.
    Type: Grant
    Filed: February 12, 1997
    Date of Patent: November 9, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Adalbert Braig, Andreas Kramer, Jean-Pierre Wolf, Markus Frey
  • Patent number: 5925661
    Abstract: The invention relates to compounds of the formula: ##STR1## Compounds of the above formula have a great affinity for the neurotensin receptors.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: July 20, 1999
    Assignee: SANOFI
    Inventors: Bernard Labeeuw, Danielle Gully, Francis Jeanjean, Jean-Charles Molimard, Robert Boigegrain
  • Patent number: 5739318
    Abstract: The present invention relates to labelling agents comprising non-proteinaceous boronic acid conjugates having absorption maxima at not less than 600 nm, said label being provided by e.g., an azine, triphenylmethane, cyanine or phthalocyanine dye. The labelling agents are useful in the estimation and quantification of cisdiols such as glycosylated haemoglobin, by virtue of the substantially total absence of overlap with the absorption spectrum of haemoglobin. Oxazine and thiazine dyes exhibiting similar absorption characteristics and containing other activated moieties are similarly useful labelling agents, especially in the presence of haemoglobin.
    Type: Grant
    Filed: July 12, 1993
    Date of Patent: April 14, 1998
    Assignee: Axis Research AS
    Inventors: Frank Frantzen, Erling Sundrehagen
  • Patent number: 5705517
    Abstract: Benzimidazole derivatives of the formula (I): ##STR1## wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R' group; R' is hydrogen or an optionally substituted hydrocarbon residue; R.sup.2 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; R' is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or convertible to an anion; Y is --O--, --S(O).sub.m -- or --N(R.sup.4)-- wherein m is an integer of 0, 1 or 2 and R.sup.4 is hydrogen or an optionally substituted alkyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g.
    Type: Grant
    Filed: October 5, 1993
    Date of Patent: January 6, 1998
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Takehiko Naka, Kohei Nishikawa
  • Patent number: 5463058
    Abstract: Novel polymethylpiperidine compounds of general formula (I) containing silane groups and effective as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials.The meanings of R.sub.1, R.sub.2, R.sub.3, R.sub.4 and n are defined in the text.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: October 31, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Primo Carrozza, Giovanni Da Roit
  • Patent number: 5434152
    Abstract: An asymmetric synthesis of (S)-(-)-6-chloro-4-cyclopropyl-3,4-dihydro-4-[(2-pyridyl)ethynyl]-2(1H)-qu inazolinone comprises the chiral addition of 2-pyridylacetylide to N.sup.1 -protected 6-chloro-4-cyclopropyl-2-quinazolinone followed by removal of the protecting group.
    Type: Grant
    Filed: November 8, 1993
    Date of Patent: July 18, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Mark A. Huffman, Nobuyoshi Yasuda, Ann E. DeCamp, Edward J. J. Grabowski
  • Patent number: 5359064
    Abstract: This invention relates to salts of triazine derivatives with oxygenated as of phoshporus, having general formula (I): ##STR1## obtained by salification, with an acid containing phosphorus, of polycondensates of 2,4,6-triamino-1,3,5-triazine. The compounds having the general formula (I) are particularly used as flame-resistant additives.
    Type: Grant
    Filed: July 10, 1991
    Date of Patent: October 25, 1994
    Assignee: Ministero Dell `Universita` e Della Ricerca Scientifica e Tecnologica
    Inventors: Roberto Cipolli, Enrico Masarati, Gilberto Nucida, Roberto Oriani, Mario Pirozzi
  • Patent number: 5098931
    Abstract: Novel HMG-CoA reductase inhibitors are useful as antihypercholesterolemic agents and are represented by structural formulae (I) and (II): ##STR1##
    Type: Grant
    Filed: September 24, 1990
    Date of Patent: March 24, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Mark E. Duggan, Wasyl Halczenko, George D. Hartman
  • Patent number: 5036152
    Abstract: Novel alkoxycarbonylalkylphospholipids, alkylaminocarbonylalkylphospholipids, processes for the preparation thereof, and methods for treating inflammation utilizing compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: July 30, 1991
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Nicholas J. Hrib, Kirk D. Shoger, John J. Tegeler
  • Patent number: 4931580
    Abstract: Aryl sulfonylureas as new compositions and included in a two-part herbicide system comprising at least one or more thiolcarbamate, thiolcarbamate sulfoxide or haloacetanilide herbicide, and as the second part a non-phytotoxic antidotally effective amount of aryl sulfonylurea as an antidote therefor of the formula ##STR1## in which X is oxygen or sulfur; n is an integer; R is lower alkyl, lower alkoxy, lower alkylthio, halogen, trifluoromethyl, cyano, nitro, lower alkyl sulfonyl;R.sup.4 is hydrogen, lower alkyl, lower alkoxyalkyl, phenyl and chlorophenyl;R.sup.2 is hydrogen, lower alkyl, alkoxyalkyl and phenyl;R.sup.1 is lower alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, 1-phenylpropenyl, benzyl, chlorobenzyl, haloalkenyl, phenyl and alkyl substituted phenyl; andAR is phenyl, benzyl, naphthyl, pyridyl or styryl; and the inorganic base salts sodium, potassium, ammonium and other inorganic salts; and organic base salts thereof.
    Type: Grant
    Filed: December 23, 1983
    Date of Patent: June 5, 1990
    Inventors: Ferenc M. Pallos, Kang-Chi Lin, Laddie L. Green
  • Patent number: 4719297
    Abstract: Acylphosphine compounds of the formula I ##STR1## where X is oxygen, sulfur or an electron pair, R.sup.1 is R.sub.4 or OR.sup.4, R.sup.2 is --OM, where M is a monovalent cation, R.sup.3 is aryl which is substituted at least at the two positions ortho to the carbonyl group, and R.sup.4 is hydrogen, alkyl or aryl, are very effective photoinitiators for photopolymerizable materials, such as coating compositions, finishes, printing inks, unsaturated polyesters, recording media and preferably aqueous polymer dispersions or solutions.
    Type: Grant
    Filed: November 20, 1984
    Date of Patent: January 12, 1988
    Assignee: BASF Aktiengesellschaft
    Inventors: Andreas Henne, Anton Hesse, Manfred Jacobi, Guenter Wallbillich, Bernd Bronstert
  • Patent number: 4710579
    Abstract: A compound provided by the present invention, of the formula ##STR1## wherein R.sup.1 is C.sub.14-20 alkyl; R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen or C.sub.1-5 alkyl, or ##STR2## represents a cyclic ammonio group; and A is C.sub.2-5 alkylene, and a pharmaceutically acceptable salt thereof, are useful as a anti-tumor agent.
    Type: Grant
    Filed: October 30, 1985
    Date of Patent: December 1, 1987
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Shoshichi Nojima, Hiroaki Nomura, Tetsuya Okutani
  • Patent number: 4689346
    Abstract: Compounds for effecting hemostatic and antifibrinolytic action, namely a 1-acylamino naphthalene-4 sulphonic acid derivative of the formula ##STR1## and compositions and method of achieving such action.
    Type: Grant
    Filed: October 28, 1985
    Date of Patent: August 25, 1987
    Assignee: Laboratorio Fides, S.A.
    Inventors: Pere P. Llobet, Elisa G. Baylina
  • Patent number: 4678496
    Abstract: As new compound is provided a cyclohexane derivative of the formula ##STR1## wherein R represents a hydrogen atom or an alkyl group, an alkylthioalkyl group or an unsubstituted or substituted phenyl group; and R.sup.1 represents an alkyl group, an unsubstituted or substituted benzyl group, a phenethyl group, a phenoxymethyl group, a 2-thienylmethyl group, an alkoxymethyl group or an alkylthiomethyl group, or a salt of said cyclohexane compound.This cyclohexane compound exhibits useful plant-growth regulating effects on crop-plants and also non-crop plants such as lawn and may be prepared by cyclization of an acetonylsuccinic acid dialkyl ester, followed by reaction with an organic acid chloride and by intermolecular rearrangement.
    Type: Grant
    Filed: August 1, 1985
    Date of Patent: July 7, 1987
    Assignee: Kumiai Chemical Industry Co., Ltd.
    Inventors: Kenji Motojima, Takeshige Miyazawa, Yasufumi Toyokawa, Masafumi Matsuzawa, Hiroshi Hokari, Shoji Kusano
  • Patent number: 4666461
    Abstract: Corrosion inhibiting additive compositions for use in alcohol and alcohol containing normally liquid hydrogen fuels derived by the reaction of at least one phosphoric acid reactant and at least one amine selected from the group consisting of morpholines and alkanolamines and alcohol and alcohol containing normally liquid hydrocarbon fuels containing said additive compositions are disclosed.
    Type: Grant
    Filed: January 17, 1986
    Date of Patent: May 19, 1987
    Assignee: The Lubrizol Corporation
    Inventor: Casper J. Dorer, Jr.
  • Patent number: 4663455
    Abstract: There is disclosed a process for the preparation of N,N'-tetrathiodimorpholine wherein an admixture of morpholine and elemental sulfur is oxidized with air or oxygen in the presence of iron salts or iron complexes in combination with zinc compounds such as ZnCl.sub.2 and ZnO to yield N,N'-tetrathiodimorpholine.
    Type: Grant
    Filed: September 4, 1986
    Date of Patent: May 5, 1987
    Assignee: The Goodyear Tire & Rubber Company
    Inventors: Angelo Bergomi, Joseph A. Kuczkowski
  • Patent number: 4565865
    Abstract: New carbamic acid esters, inclusive of salts thereof, which have the formula: ##STR1## wherein n is zero or 1; R.sup.1 and R.sup.2 independently represent --H, --OCH.sub.3 or --OCONHR.sup.6 in which R.sup.6 is C.sub.8-26 aliphatic hydrocarbon residue provided that at least one of R.sup.1 and R.sup.2 is --OCONHR.sup.6 ; and R.sup.3, R.sup.4 and R.sup.5 independently represent hydrogen or lower alkyl, or ##STR2## represents cyclic ammonio, exhibit inhibitory activity to multiplication of tumor cells and antimicrobial activity.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: January 21, 1986
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Motoo Hozumi, Hiroaki Nomura, Yoshio Yoshioka
  • Patent number: 4540807
    Abstract: Di- and other poly-sulfosuccinate esters of di- and other poly-hydroxyl aromatic propoxylated compounds in which, by way of illustration, both of the hydroxyl groups of a bisphenol, for instance, Bisphenol A, are etherified with a propylene oxide .alpha.-epoxide, the free hydroxyl groups of the resulting propoxylated bisphenol then being esterified with a sufficient amount of maleic anhydride whereby the resulting intermediate acid ester compound comprises di- and/or poly-maleic acid esters having free carboxyl groups which are then esterified with propylene oxide .alpha.-epoxide to produce a further intermediate having a free hydroxyl group at each of its terminal ends; and after which said last-mentioned intermediate is reacted to introduce at least two sulfosuccinated groups into the final compound, for instance, by reaction with aqueous bisulfite.
    Type: Grant
    Filed: September 30, 1981
    Date of Patent: September 10, 1985
    Assignee: Witco Chemical Corporation
    Inventors: Kermit D. Longley, Anastasios Karalis
  • Patent number: 4495363
    Abstract: N-phosphonomethylglycine and novel derivatives thereof useful as phytotoxicants or herbicides.
    Type: Grant
    Filed: March 24, 1982
    Date of Patent: January 22, 1985
    Assignee: Monsanto Co.
    Inventor: John E. Franz
  • Patent number: 4486429
    Abstract: Compounds of the formula I: ##STR1## in which R represents a hydrogen atom or an alkyl radical containing from 1 to 8 carbon atoms and R.sub.1 and R.sub.2, which may be identical or different independently represent a hydrogen atom, an alkyl radical containing from 1 to 4 carbon atoms, a --CONH.sub.2 radical, a --CO.sub.2 alk.sub.1 radical in which alk.sub.1 represents an alkyl radical containing from 2 to 8 carbon atoms, or an--SO.sub.2 alk.sub.2 radical in which alk.sub.2 represents an alkyl radical containing from 1 to 8 carbon atoms, or R.sub.1 and R.sub.2 together with the nitrogen atom form a heterocycle provided that R.sub.1 and R.sub.2 are not both hydrogen, as well as the alkali metal, alkaline earth metal, ammonium or amine salts of compounds of formula I in which R represents a hydrogen atom. These compounds are useful in treating hyperchlorhydria, gastric or gastroduodenal ulcers, gastritis, hiatal hernias and gastric or gastroduodenal ailments accompanied by gastric hyperacidity.
    Type: Grant
    Filed: October 20, 1982
    Date of Patent: December 4, 1984
    Assignee: Roussel Uclaf
    Inventors: Mario Bianchi, Fernando Barzaghi
  • Patent number: 4480119
    Abstract: Unsymmetrical sulfosuccinate diesters in which one carboxyl group of the sulfosuccinate is esterified with an alcohol, for instance, a C.sub.8 -C.sub.12 aliphatic monohydric alcohol such as octyl or dodecyl alcohol, or with an ethoxylated or propoxylated alkyl phenol, and in which the other carboxyl group is esterified by reaction with ethylene oxide, and method of preparation of such diesters. The said diesters have utility as surfactants, such as detergents and emulsifiers.
    Type: Grant
    Filed: June 18, 1979
    Date of Patent: October 30, 1984
    Inventors: Kermit D. Longley, Anastasios J. Karalis
  • Patent number: 4455295
    Abstract: N-(p-sulfophenyl)-cinnamamide, which is optionally present in the form of a salt, can be prepared by the reaction of cinnamoyl chloride with sulphanilic acid in the presence of a tertiary amine. The new compound can be used in light-protection agents.
    Type: Grant
    Filed: May 6, 1983
    Date of Patent: June 19, 1984
    Assignee: Haarmann & Reimer GmbH
    Inventors: Rudolf Hopp, Horst Finkelmeier, Roland Langner
  • Patent number: 4438112
    Abstract: Prostanoids are described of the formulae ##STR1## (and the salts thereof) in which: X is cis or trans --CH.dbd.CH-- or CH.sub.2 CH.sub.2 --;R.sup.1 is C.sub.1-7 alkyl terminated by --COOR.sup.10 where R.sup.10 is H, C.sub.1-6 alkyl or aralkyl;Y is a saturated heterocyclic amino group; andR.sup.4 is aralkyl (in which the aryl portion is substituted by alkylthio, alkylsulphinyl, alkylsulphonyl, alkanoylamino, aroylamino, phenalkyl, aminosulphonyl, alkanoylaminosulphonyl, phenylsulphonyl, nitro, tetrazolyl, substituted phenyl or thienyl).These compounds inhibit blood platelet aggregation and have bronchodilatory action, and may be formulated for use as anti-asthmatics and antithrombotic agents.
    Type: Grant
    Filed: September 17, 1982
    Date of Patent: March 20, 1984
    Assignee: Glaxo Group Limited
    Inventors: Eric W. Collington, Peter Hallett, Christopher J. Wallis, John Bradshaw
  • Patent number: 4405531
    Abstract: N-phosphonomethylglycine and novel derivatives thereof useful as phytotoxicants or herbicides.
    Type: Grant
    Filed: March 8, 1982
    Date of Patent: September 20, 1983
    Assignee: Monsanto Company
    Inventor: John E. Franz
  • Patent number: 4372894
    Abstract: A compound of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different, and each is selected from the group consisting of hydrogen and phenyl groups of the formula ##STR2## wherein R.sub.4 and R.sub.5 are the same or different and each is selected from the group consisting of hydrogen, halogen, alkyl having 1, 2, or 3 carbon atoms, alkoxy having 1, 2, or 3 carbon atoms, alkoxycarbonyl having 2-7 carbon atoms; and alkylcarbonyl groups having 2-7 carbon atoms; or R.sub.4 and R.sub.5 together from a straight saturated alkylene chain having 3 or 4 carbon atoms and being bound to adjacent positions, i.e. 2,3- or 3,4- in the phenyl ring; provided that one of R.sub.1 and R.sub.2 is a phenyl group of the formula II when R.sub.3 is H; and physiologically acceptable salts and optical isomers thereof; methods for preparation of the compounds, pharmaceutical compositions containing them, and their medicinal use.
    Type: Grant
    Filed: November 13, 1979
    Date of Patent: February 8, 1983
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Ake J. E. Helgstrand, Karl N. Johannson, Alfons Misiorny, Jan O. Noren, Goran Stening
  • Patent number: 4369317
    Abstract: A membrane for use in the determination of calcium ion concentration in an aqueous solution, the membrane being of the type comprising a calcium ion selective component and a carrier material.
    Type: Grant
    Filed: June 29, 1981
    Date of Patent: January 18, 1983
    Assignee: Beckman Instruments, Inc.
    Inventor: John J. Hawkins
  • Patent number: 4342756
    Abstract: Compounds are described of the formula ##STR1## (and their salts and solvates) in which: X is cis or trans --CH.dbd.CH--;R.sup.1 is C.sub.1-7 alkyl terminated by --COOR.sup.3 where R.sup.3 is H, C.sub.1-6 alkyl or C.sub.7-10 aralkyl;Y is a saturated heterocyclic amino group having 5-8 ring members; andR.sup.2 is C.sub.2-4 alkanoyl, C.sub.3-6 alkenyl (optionally substituted), C.sub.1-12 alkyl, or substituted or unsubstituted phenylalkyl, biphenylalkyl or naphthylalkyl.These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic and anti-asthmatic agents.
    Type: Grant
    Filed: April 29, 1981
    Date of Patent: August 3, 1982
    Assignee: Glaxo Group Limited
    Inventors: Eric W. Collington, Peter Hallett, Christopher J. Wallis, John Bradshaw, Norman F. Hayes
  • Patent number: 4338258
    Abstract: Fluorescent dyestuffs of the general formula ##STR1## wherein R and R.sup.1 independently of one another represent hydrogen, a salt-forming cation, an alkyl radical with 1 to 16 C atoms or an aryl or aralkyl radical which is optionally substituted by non-chromophoric groups,R.sup.2 to R.sup.5 independently of one another represent hydrogen, alkyl, trifluoromethyl, alkoxy, aralkoxy, alkenoxy, aryloxy, halogen or a carboxyl, cyano, alkyl sulphone, aryl sulphone, aralkyl sulphone, carboxamide, sulphonamide or carboxylic acid ester group,o, p, q and s independently of one another represent 1 or 2 andm and n independently of one another denote 0, 1 or 2, it being possible for the sum of m and n to be 2 to 4,processes for their preparation and their use as laser dyestuffs.
    Type: Grant
    Filed: September 8, 1980
    Date of Patent: July 6, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Brinkwerth, Wolfgang Huffer, Roderich Raue, Rudolf Schieder, Helmut Telle
  • Patent number: 4338440
    Abstract: A membrane for use in the determination of calcium ion concentration in an aqueous solution, the membrane being of the type comprising a calcium ion selective component and a carrier material.
    Type: Grant
    Filed: October 14, 1980
    Date of Patent: July 6, 1982
    Assignee: Beckman Instruments, Inc.
    Inventor: John J. Hawkins
  • Patent number: 4321081
    Abstract: A compound of the formula: ##STR1## wherein R is C.sub.1 -C.sub.4 alkylamino, C.sub.3 -C.sub.4 alkenylamino, C.sub.3 -C.sub.4 alkynylamino, di(C.sub.1 -C.sub.4)alkylamino, di(C.sub.3 -C.sub.4)alkenylamino, di(C.sub.3 -C.sub.4)alkynylamino, C.sub.1 -C.sub.4 alkyl(C.sub.3 -C.sub.4)alkenylamino, C.sub.1 -C.sub.4 alkyl(C.sub.3 -C.sub.4)alkynylamino, C.sub.1 -C.sub.4 alkoxyamino, C.sub.1 -C.sub.4 alkyl(C.sub.1 -C.sub.4)alkoxyamino, C.sub.1 -C.sub.4 alkylphenylamino, morpholino, thiomorpholino, C.sub.1 -C.sub.4 alkylmorpholino, di(C.sub.1 -C.sub.4)alkylmorpholino, pyrrolidino, C.sub.1 -C.sub.4 alkylpyrrolidino, piperidino, C.sub.1 -C.sub.4 alkylpiperidino, hexamethyleneimino or tetrahydropyridino and n is an integer of 0 or 1, or a salt thereof, which is useful as a herbicide.
    Type: Grant
    Filed: April 3, 1981
    Date of Patent: March 23, 1982
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Hiroyuki Konishi, Shunichi Hashimoto, Hiromichi Oshio
  • Patent number: 4310683
    Abstract: Sulfosuccinate diesters in which one carboxyl group of the sulfosuccinate is esterified with an ethoxylated or propoxylated non-tertiary monoamine, for instance, a C.sub.8 -C.sub.18 fatty amine, ethoxylated with 3 or 4 moles of ethylene oxide, to form a hydroxyl-containing tertiary amine, and in which the other carboxyl group of the sulfosuccinate is esterified with an .alpha.-monoepoxide such as propylene oxide, or higher .alpha.-monoepoxides, and method of preparation of such sulfosuccinate diesters. The said sulfosuccinate diesters have utility as surfactants, such as detergents and emulsifiers.
    Type: Grant
    Filed: June 15, 1979
    Date of Patent: January 12, 1982
    Assignee: Witco Chemical Corporation
    Inventors: Kermit D. Longley, Anastasios J. Karalis
  • Patent number: 4271002
    Abstract: A membrane for use in the determination of calcium ion concentration in an aqueous solution, the membrane being of the type comprising a calcium ion selective component and a carrier material.
    Type: Grant
    Filed: December 26, 1979
    Date of Patent: June 2, 1981
    Assignee: Beckman Instruments, Inc.
    Inventor: John J. Hawkins
  • Patent number: 4267122
    Abstract: Aminosulfonylcarboxylic acids and their manufacture from diamines and chlorosulfonylcarboxylic acids.
    Type: Grant
    Filed: September 27, 1978
    Date of Patent: May 12, 1981
    Assignee: BASF Aktiengesellschaft
    Inventors: Lucien Thil, Martin Fischer, Wolfgang Kindscher
  • Patent number: 4263431
    Abstract: The invention relates to cationic fluorescent whitening agents of the formula ##STR1## wherein A is the radical of a fluorescent whitening agent, Q is the direct bond or a bridge member, R.sub.1 to R.sub.5 are specific substituents and n is 1 or 2. A process for the manufacture of these compounds and a method of whitening organic material which comprises their use are also disclosed.
    Type: Grant
    Filed: May 17, 1979
    Date of Patent: April 21, 1981
    Assignee: Ciba-Geigy Corporation
    Inventors: Kurt Weber, Christian Luthi, Hans R. Meyer
  • Patent number: 4242511
    Abstract: The invention relates to an improved process for making amine salts of acid O,S-dialkylthiophosphoric acid esters of the general formula (I) ##STR1## in which R.sub.1 stands for the ammonium ion of primary or secondary aliphatic, cycloaliphatic or aromatic amines or of a heterocyclic nitrogen base and R.sub.2 and R.sub.3 each stand for an alkyl group by subjecting an O,O,S-trialkyl-thiophosphate to partial dealkylation and forming the salt of the dealkylated product by treatment with an amine corresponding to the ammonium ion R.sub.1. In the improved process an O,O,S-trialkylthiophosphate of the general formula (II) ##STR2## in which R.sub.2 and R.sub.3 have the meanings given above, is mixed with at least stoechiometric proportions of water and an amine corresponding to the ammonium ion R.sub.1, the resulting mixture is reacted, with agitation, over a period of about 3 to 8 hours at a temperature within the range 0.degree. to 120.degree. C.
    Type: Grant
    Filed: September 4, 1979
    Date of Patent: December 30, 1980
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Jurgen Grosse
  • Patent number: 4160089
    Abstract: An aqueous composition for the working of metals comprising in solution in water at least one salt of an orthophosphoric ester of the formula: ##STR1## in which R is a hydrocarbon group containing between 10 and 20 carbon atoms and at least two atoms of chlorine, R' is hydrogen or a hydrocarbon group, identical or not to R, whose carbon chain contains between 10 and 20 carbon atoms and at least two atoms of chlorine.
    Type: Grant
    Filed: July 15, 1977
    Date of Patent: July 3, 1979
    Assignee: Aquila S.p.A.
    Inventors: Giancarlo Bussi, Pierpaolo Baradel
  • Patent number: 4154955
    Abstract: Sulfosuccinate ester-amides in which one carboxyl group of the sulfosuccinate is amidified with an aliphatic non-tertiary amine, for instance, a C.sub.8 -C.sub.12 aliphatic amine such as octyl or dodecyl amine, and in which the other carboxyl group of the sulfosuccinate is esterified by reaction with an .alpha.-monoepoxide such as propylene oxide, or higher .alpha.-monoepoxides, and method of preparation of such sulfosuccinate ester-amides. The said sulfosuccinate ester-amides have utility as surfactants, such as detergents and emulsifiers.
    Type: Grant
    Filed: October 25, 1977
    Date of Patent: May 15, 1979
    Assignee: Witco Chemical Corporation
    Inventors: Kermit D. Longley, Anastasios J. Karalis